#good blood sugar

[reasonsforhope]

"People living with diabetes might have a new hope. Scientists have tested a new drug therapy in diabetic mice, and found that it boosted insulin-producing cells by 700% over three months, effectively reversing their disease.

Beta cells in the pancreas have the important job of producing insulin in response to blood sugar levels, but a hallmark of diabetes is that these cells are either destroyed or can’t produce enough insulin. The most common treatment is regular injections of insulin to manage blood sugar levels.

But a recent avenue of research has involved restoring the function of these beta cells. In some cases that’s started with stem cells being coaxed into new beta cells, which are then transplanted into patients with diabetes. Researchers behind this kind of work have described it as a “functional diabetes cure.”

Now, scientists at Mount Sinai and City of Hope have demonstrated a new breakthrough. Previous studies have mostly involved growing new beta cells in a lab dish, then transplanting them into mice or a small device in humans. But this new study has been able to grow the insulin-producing cells right there in the body, in a matter of months.

The therapy involved a combination of two drugs: one is harmine, a natural molecule found in certain plants, which works to inhibit an enzyme called DYRK1A found in beta cells. The second is a GLP1 receptor agonist. The latter is a class of diabetes drug that includes Ozempic, which is gaining attention lately for its side effect of weight loss.

The researchers tested the therapy in mouse models of type 1 and 2 diabetes. First they implanted a small amount of human beta cells into the mice, then treated them with harmine and GLP1 receptor agonists. Sure enough, the beta cells increased in number by 700% within three months of the treatment. The signs of the disease quickly reversed, and stayed that way even a month after stopping the treatment.

“This is the first time scientists have developed a drug treatment that is proven to increase adult human beta cell numbers in vivo,” said Dr. Adolfo Garcia-Ocaña, corresponding author of the study. “This research brings hope for the use of future regenerative therapies to potentially treat the hundreds of millions of people with diabetes.”

The results are intriguing, but of course being an animal study means there’s still much more work to be done before it could find clinical use. So far, harmine alone has recently undergone a phase 1 clinical trial in humans to test its safety and tolerability, while other DYRK1A inhibitors are planned for trials in humans next year.

Perhaps most importantly, the team will soon experiment with combining beta-cell-regenerating drugs with others that modulate the immune system. Ideally this should help overcome a major hurdle: the immune system will continue attacking new beta cells as they’re produced.

The research was published in the journal Science Translational Medicine."

-via New Atlas, July 14, 2024

[unpretty]

god i wish there was a section in mychart to put "we do not have to spend twenty minutes re-litigating the evidence in her fitness tracker before ordering more bloodwork because her existing bloodwork is too good for an ass that fat"

[chaos0pikachu]

This tweet from Bible about today's episode says so much and so little at the same time

[meowrinth]

its shit but i wanna share the cake i did for my brother's bday 😭😭😭 m&m + b <3 (he absolutely loved it, it was the exact amount of ugly that he wanted)

[tj-crochets]

Went to the doctor just for a check up and he basically just told me "your body just processes sugar very well! :) :) :) It's a good thing! :) :) :) It can't possibly be the source of your symptoms even though eating fixes it :) :) :)" But there was also a moment when talking about my iron deficiency that is possibly one of the funniest things a doctor has ever said to me, up with the cardiologist who said "you're a medical mystery": He was going over my blood test results, and said "Your iron levels haven't gone up at all, they are still extremely low, but you're not anemic anymore" And I was like how am I not anemic anymore??? And he said "Your hemoglobin levels have gone up...somehow..." while frowning at the blood test results on his computer. It was very "somehow, palpatine has returned" lol

[sysig]

Time Loops are they/them culture (Patreon)

Bonus of my little guy in ISaT style:

[chainsawmascara]

Idk man, I'm not bothered with aa, he's out here controlling the city and I'm sitting in his lap looking pretty bc I don't want r e s p o n s i b i l i t i e s. Go off, toxic king, hand me a goblet of blood and give me an allowance.

[naamahdarling]

.

[after-witch]

so I went to the bookstore today (dressed up extremely cute in my Metamorphose temps de fille apple print dress, as you do!!) to pick up the Jujutsu Kaisen light novels because I didn't know there was a Mahito chapter until someone mentioned it

and I was debating about whether or not to pick up the first few volumes of the manga as well, because Barnes & Noble is having a double points on their reward count sale for Labor Day

and the store only had one copy of each volume

and I was hemming and hawwing so I went down the aisle to think about it and also look at some Japanese novels they had on a small display

and when I did a girl, young teen maybe 13 or so came up with her mom, all jumping and excited to see they had JJK, telling her it's exactly what she'd been talking about and she grabbed the first 3 volumes to buy

and I'm so glad I didn't get them!!! 'cause now she gets to read them.

[einsatzzz]

YASSS!!! HIBARI'S POP-UP PARADE FIGURE IS HERE!!! 🥹💜💜💜✨✨ I wish I knew how to take prettier pictures dsbhhdsbs I'm putting him in my work desk for now 🥰👍✨

[carltonlassie]

So I'm on a Greyhound (already a bad start) and I had to give my witness statement to COPS in the middle of the journey and I was a bit shaken about the whole thing but now I feel more normal and I'm more occupied with directing my energy towards not peeing my pants, so there's a good thing

[arsonistman]

Why is every diabetes friendly meal soup, chicken and veggies, or a salad

[savage-rhi]

*insert pink color here*

[many-gay-magpies]

hng

[prettyflyshyguy]

Alright motherfuckers I finished inFAMOUS 2 (blue karma)

I have many thoughts, and I won't be doing a red run anytime soon (I need to get back to working more, and look I'll be real; I'm installing Festival of Blood and that's going to obliterate me and THEN I need to quit) - I'm going to be watching a full evil karma playthrough on yt and at some point I'll write up some more coherent thoughts but for now:

Game fucking good, however, I really wish it took some of the themes further cause it had some REALLY GOOD SHIT going on and didn't take it quite as far as I'd love for it to go. It's left me with my brain still on fire, and I mostly just wish there was more time spend with these characters. They were fun. I liked them a lot.

[clonerightsagenda]

There was probably a more reasonable way to deal with this whole situation (like scheduling a separate earlier timeslot to do bloodwork) but I'm committed at this point. I'm grumpily making eggs at 9 pm and liveblogging a children's book for another 3 hours in the desperate hope that I can confuse my body enough that I don't pass out while driving to the hospital as punishment for not eating until 10 am tomorrow.