#good blood sugar

[dreamdripdistance]

✦ the most consistent part of this life, is that the sun will always rise and there's stars in the night ✦ (the reverse)

[reasonsforhope]

"People living with diabetes might have a new hope. Scientists have tested a new drug therapy in diabetic mice, and found that it boosted insulin-producing cells by 700% over three months, effectively reversing their disease.

Beta cells in the pancreas have the important job of producing insulin in response to blood sugar levels, but a hallmark of diabetes is that these cells are either destroyed or can’t produce enough insulin. The most common treatment is regular injections of insulin to manage blood sugar levels.

But a recent avenue of research has involved restoring the function of these beta cells. In some cases that’s started with stem cells being coaxed into new beta cells, which are then transplanted into patients with diabetes. Researchers behind this kind of work have described it as a “functional diabetes cure.”

Now, scientists at Mount Sinai and City of Hope have demonstrated a new breakthrough. Previous studies have mostly involved growing new beta cells in a lab dish, then transplanting them into mice or a small device in humans. But this new study has been able to grow the insulin-producing cells right there in the body, in a matter of months.

The therapy involved a combination of two drugs: one is harmine, a natural molecule found in certain plants, which works to inhibit an enzyme called DYRK1A found in beta cells. The second is a GLP1 receptor agonist. The latter is a class of diabetes drug that includes Ozempic, which is gaining attention lately for its side effect of weight loss.

The researchers tested the therapy in mouse models of type 1 and 2 diabetes. First they implanted a small amount of human beta cells into the mice, then treated them with harmine and GLP1 receptor agonists. Sure enough, the beta cells increased in number by 700% within three months of the treatment. The signs of the disease quickly reversed, and stayed that way even a month after stopping the treatment.

“This is the first time scientists have developed a drug treatment that is proven to increase adult human beta cell numbers in vivo,” said Dr. Adolfo Garcia-Ocaña, corresponding author of the study. “This research brings hope for the use of future regenerative therapies to potentially treat the hundreds of millions of people with diabetes.”

The results are intriguing, but of course being an animal study means there’s still much more work to be done before it could find clinical use. So far, harmine alone has recently undergone a phase 1 clinical trial in humans to test its safety and tolerability, while other DYRK1A inhibitors are planned for trials in humans next year.

Perhaps most importantly, the team will soon experiment with combining beta-cell-regenerating drugs with others that modulate the immune system. Ideally this should help overcome a major hurdle: the immune system will continue attacking new beta cells as they’re produced.

The research was published in the journal Science Translational Medicine."

-via New Atlas, July 14, 2024

[chaos0pikachu]

This tweet from Bible about today's episode says so much and so little at the same time

[deadlysoupy]

i won't... post this anywhere i think but i DO HOPE that people consider starbee as like. a two-way street. like it's not ONLY about starscream and HIS trauma it's also about bumblebee. star isn't the only one allowed to have a "sad and abusive" backstory. bee has one too, he just doesn't express it as loudly or it's never addressed in a way that could be visually seen

they BOTH get something out of this relationship. not in a parasitic way, just that they both fulfil each other's needs and fill a hole that formed in their heart. that's what a good relationship is to me. it's when both people in a relationship have that the other needs, and they depend on each other to bring out something they couldn't access before

now i haven't actually seen people say that "starscream's character is more important in starbee" (mainly bc it's still a rareship no matter how much i wish it wasn't LMAO) but STILL just want to remind everyone. just because you could visually tell star's more affected by his past and present than bee is doesn't mean bee's perfectly healthy and should serve as star's "clutch" all the time. they support each other

[thistransient]

The guesthouse auntie told me to take the bus from Ernakulam but did I listen, nooo

[longlivethewildernessyet]

things are certainly thinging on the art front

why is it so hard to get a vibrant red on black paper

[tj-crochets]

Went to the doctor just for a check up and he basically just told me "your body just processes sugar very well! :) :) :) It's a good thing! :) :) :) It can't possibly be the source of your symptoms even though eating fixes it :) :) :)" But there was also a moment when talking about my iron deficiency that is possibly one of the funniest things a doctor has ever said to me, up with the cardiologist who said "you're a medical mystery": He was going over my blood test results, and said "Your iron levels haven't gone up at all, they are still extremely low, but you're not anemic anymore" And I was like how am I not anemic anymore??? And he said "Your hemoglobin levels have gone up...somehow..." while frowning at the blood test results on his computer. It was very "somehow, palpatine has returned" lol

[umesakus]

my doordasher actually came into the building and brought the food directly up to my door instead of leaving it outside...... god is real

[egginfroggin]

Had a bit of a bad spot today

Doodled a little Greg when I felt better

Here's a little Greg for you if you're feeling down

Please hang in there <3

(program: krita; time: like 15 minutes)

[mars-ipan]

wuh oh (<- lightheaded)

[ratsplendor]

Just finished reading your Hilson knife play fic, I think I’m in love.

I was on a crowded train and I couldn’t make faces and that was tough ‘cause I wanted to grin like a maniac. I had to text my best friend screaming about it, it was that good.

If you’ve any more kinky hilson thoughts, I’d love to hear them.

I saw your sweet comment on "blood sugar"!! thanks for reading and hanging out, truly means so much to me!! 💕

hm hm more kinky Hilson thoughts...

so i have this draft sitting in my bin. it's around 13k words at this point of, like, House figuring out Wilson has a thing for praise when he's drunk and exploiting it for years until the divorce era (shockingly original, i know) when it all comes to a head. one almost-drunk night turns into a little something more and nobody handles it entirely gracefully.

the problem is i'm so rarely in the mood to write dom!House. but when i *am*, oh, boy, is he a wacky sonofabitch. it's not writing him mean that's the difficult part, it's writing him soft, which this fic sort of demands because this isn't a hatefucking sort of situation, this is Wilson, who turns into this little molten puddle of unhinged need, though not without a lot of House-typical poking and prodding. Wilson, who's always been the caretaker, never the other way round. letting go like this is a lot for him, and while i'm not trying to get House to handle it *perfectly,* he is at the very least *trying.*

the mean parts are fine, they fly by without me having to think about it too much, but the in-between sort of what do i do here or why do i want to pat him on the head right now and not in a mean way parts, where i'm trying to get it to still be believably House being bewildered over why he's not being more of a bastard...those are the difficult parts lol.

so i return to this document once in a blue moon and write like 100 words at a time and then yell incoherently into the nearest pillow bc idk what i'm doing. hahah i'm sure it'll be finished someday but in the meantime, please have this delightful scene. Wilson is face-first against the front door of the apartment here, in case you were wondering, having just come in after insinuating he might not spend the night alone the day before (he's moved out for plot reasons. don't think too hard about it).

[sysig]

Time Loops are they/them culture (Patreon)

Bonus of my little guy in ISaT style:

[chainsawmascara]

Idk man, I'm not bothered with aa, he's out here controlling the city and I'm sitting in his lap looking pretty bc I don't want r e s p o n s i b i l i t i e s. Go off, toxic king, hand me a goblet of blood and give me an allowance.

[donnovien]

Jing Lin said, “… Isn’t this…”

“The real man himself.” Cang Ji’s arm tightened around him. He said, “Isn’t this Jing Lin? Am I not hugging you in my arms?”

“I was pursuing you…” Jing Lin turned his head to the side and asked with complicated feelings, “I love you?”

“I was pursuing you.” Cang Ji did not reply, but repeated in a resolute tone. “I love you.”

These words were so scalding they made Jing Lin flustered. The stone in his sleeve finally seized the opportunity and tumbled out to turn around in circles disbelievingly beside their legs. Cang Ji retracted his feet and stuffed the stone back into his own sleeve.

“I love you.” Cang Ji said even more intensely. “I love Lord Lin Song, Jing Lin. Why aren’t you looking at me? You are burning up. Did my words make you feel hot or did they make you feel embarrassed?”

Jing Lin pursed his lips tightly and said nothing.

Cang Ji said, “If you don’t look at me, I’ll say it all night.”

Jing Lin immediately turned his head with surprise and fear in his eyes. It was the first time he had revealed such an expression in this patchwork body of his. He was even a little inarticulate as he said, “I don’t want… I don’t want to listen.”

“Is that so?” Cang Ji emphasized his words. “Then do you also not want to listen to how I not only love you, but also want to hug you, caress you, and take you into my mouth? If that’s the case, I’ll stop it—in your dreams!”

The stone struggled in Cang Ji’s sleeve but failed to escape. Jing Lin was dazed for a moment, then he unexpectedly raised his hands to cover his ears. His face, which was initially expressionless, gradually took on a look of anger and shame under Cang Ji’s gaze.

“… Then I will say it too!”

Cang Ji let out a laugh. “I couldn’t ask for more. Bring it on. I’m all ears.”

[naamahdarling]

.

[after-witch]

so I went to the bookstore today (dressed up extremely cute in my Metamorphose temps de fille apple print dress, as you do!!) to pick up the Jujutsu Kaisen light novels because I didn't know there was a Mahito chapter until someone mentioned it

and I was debating about whether or not to pick up the first few volumes of the manga as well, because Barnes & Noble is having a double points on their reward count sale for Labor Day

and the store only had one copy of each volume

and I was hemming and hawwing so I went down the aisle to think about it and also look at some Japanese novels they had on a small display

and when I did a girl, young teen maybe 13 or so came up with her mom, all jumping and excited to see they had JJK, telling her it's exactly what she'd been talking about and she grabbed the first 3 volumes to buy

and I'm so glad I didn't get them!!! 'cause now she gets to read them.