#foundation health

[innonurse]

US government now investigating recent Change Healthcare cyberattack

- By InnoNurse Staff -

The US government is currently examining the recent Change Healthcare cyberattack to see whether or not sensitive consumer and patient information was stolen.

Read more at TechRadar

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Other recent news and insights

A new AI approach identifies 90% of lymphatic cancer cases (Chalmers University of Technology/Medical Xpress) Study demonstrates the possibility for employing AI technologies to detect health-care-associated infections (Association for Professionals in Infection Control/Medical Xpress) Using generative AI assistant to evaluate pharmacogenetic test findings (Baylor College of Medicine) Data science: HiLabs raises $39 million funding round (Fierce Healthcare) Utah: BioHive will develop a HealthTech Hub Chapter to promote medical innovation and 'disrupt healthcare' (Utah Business) Health IT: Foundation Health secured $6 million to 'drive next-generation consumer experiences' (MobiHealthNews)

[biggest-gaudiest-patronuses]

anyone else have multiple traumatic memories associated specifically with holidays/family vacations? because that is a topic I never see discussed in all the So You Had A Shitty Childhood, Now What? self-help books i've been reading. but for me, it was a significant thing. and the more i think about it the more it seems like this would be an (unfortunately) common experience. would be grateful to hear if this matches other peoples' experiences...

[brainrotisseriechicken]

cain doodle

[mindblowingscience]

More than 3,600 chemicals used in food packaging or preparation have been detected in human bodies, some of which are hazardous to health, while little is known about others, a study published on Tuesday said. Around 100 of these chemicals are considered to be of "high concern" to human health, said lead study author Birgit Geueke from the Food Packaging Forum Foundation, a Zurich-based NGO. Some of these chemicals are relatively well-studied and have already been found in human bodies, such as PFAS and bisphenol A – both of which are the target of bans.

Continue Reading.

[m0oncak3]

Dr Jack Bright is my mental stability.

The hand is inside out but idgaf

[lizzybeeee]

Who wants to bet that Anders was planned to be in that post-credit's Executor cutscene montage but they changed it to Bartrand when they realized it would go over real badly with everyone?

[stardustings]

I’m dead serious when I say keep the promises you make to yourself (and others) and you will transform. It builds self esteem like nothing else, but will also massively accelerate your life too. If you can’t be sure you’ll follow through, stop telling yourself you’ll start the exercise, pick up that hobby, make that call. Be honest with yourself. Your self esteem degrades every single time you don’t follow through. Your relationships tarnish every single time you don’t follow through. If you make that promise I’m sorry but you have to push yourself (within reason) to follow through. Not everything is about being comfortable at all times. It’s okay if you have to take a bit of time after to recover from exertion. You will build character. If you only stick to one piece of self improvement advice, make it this one. I’m dead serious!!!!!!!!!

[spookygibberish]

Can a throne eat bones? Cats will often just crunch up the bones of small animals and swallow them. Can a throne or headless do the same?

Yes, they can. That being said, I doubt that Thrones and Headless alike are immune to the hazards of eating cooked bones. This doesn't mean they don't do it, of course. I wouldn't be terribly surprised if "perforated intestine" wasn't a rare sort of death.

But It's just so much more civilized to cook your food, risk or no.

[whatareyoureallyafraidof]

[emby-m]

What has four legs in the morning, two legs in the afternoon, and three legs at night?

(an exploration of andreas over the course of 25 years, plus quotes)

[sbrown82]

So, not only did Harry and Meghan finance this trip with their own resources, their Archewell Foundation just announced three major contributions to support education, culture and community well-being in the areas they visited.

#ShowUpDoGood

[jcmarchi]

Brain pathways that control dopamine release may influence motor control

New Post has been published on https://thedigitalinsider.com/brain-pathways-that-control-dopamine-release-may-influence-motor-control/

Brain pathways that control dopamine release may influence motor control

Within the human brain, movement is coordinated by a brain region called the striatum, which sends instructions to motor neurons in the brain. Those instructions are conveyed by two pathways, one that initiates movement (“go”) and one that suppresses it (“no-go”).

In a new study, MIT researchers have discovered an additional two pathways that arise in the striatum and appear to modulate the effects of the go and no-go pathways. These newly discovered pathways connect to dopamine-producing neurons in the brain — one stimulates dopamine release and the other inhibits it.

By controlling the amount of dopamine in the brain via clusters of neurons known as striosomes, these pathways appear to modify the instructions given by the go and no-go pathways. They may be especially involved in influencing decisions that have a strong emotional component, the researchers say.

“Among all the regions of the striatum, the striosomes alone turned out to be able to project to the dopamine-containing neurons, which we think has something to do with motivation, mood, and controlling movement,” says Ann Graybiel, an MIT Institute Professor, a member of MIT’s McGovern Institute for Brain Research, and the senior author of the new study.

Iakovos Lazaridis, a research scientist at the McGovern Institute, is the lead author of the paper, which appears today in the journal Current Biology.

New pathways

Graybiel has spent much of her career studying the striatum, a structure located deep within the brain that is involved in learning and decision-making, as well as control of movement.

Within the striatum, neurons are arranged in a labyrinth-like structure that includes striosomes, which Graybiel discovered in the 1970s. The classical go and no-go pathways arise from neurons that surround the striosomes, which are known collectively as the matrix. The matrix cells that give rise to these pathways receive input from sensory processing regions such as the visual cortex and auditory cortex. Then, they send go or no-go commands to neurons in the motor cortex.

However, the function of the striosomes, which are not part of those pathways, remained unknown. For many years, researchers in Graybiel’s lab have been trying to solve that mystery.

Their previous work revealed that striosomes receive much of their input from parts of the brain that process emotion. Within striosomes, there are two major types of neurons, classified as D1 and D2. In a 2015 study, Graybiel found that one of these cell types, D1, sends input to the substantia nigra, which is the brain’s major dopamine-producing center.

It took much longer to trace the output of the other set, D2 neurons. In the new Current Biology study, the researchers discovered that those neurons also eventually project to the substantia nigra, but first they connect to a set of neurons in the globus palladus, which inhibits dopamine output. This pathway, an indirect connection to the substantia nigra, reduces the brain’s dopamine output and inhibits movement.

The researchers also confirmed their earlier finding that the pathway arising from D1 striosomes connects directly to the substantia nigra, stimulating dopamine release and initiating movement.

“In the striosomes, we’ve found what is probably a mimic of the classical go/no-go pathways,” Graybiel says. “They’re like classic motor go/no-go pathways, but they don’t go to the motor output neurons of the basal ganglia. Instead, they go to the dopamine cells, which are so important to movement and motivation.”

Emotional decisions

The findings suggest that the classical model of how the striatum controls movement needs to be modified to include the role of these newly identified pathways. The researchers now hope to test their hypothesis that input related to motivation and emotion, which enters the striosomes from the cortex and the limbic system, influences dopamine levels in a way that can encourage or discourage action.

That dopamine release may be especially relevant for actions that induce anxiety or stress. In their 2015 study, Graybiel’s lab found that striosomes play a key role in making decisions that provoke high levels of anxiety; in particular, those that are high risk but may also have a big payoff.

“Ann Graybiel and colleagues have earlier found that the striosome is concerned with inhibiting dopamine neurons. Now they show unexpectedly that another type of striosomal neuron exerts the opposite effect and can signal reward. The striosomes can thus both up- or down-regulate dopamine activity, a very important discovery. Clearly, the regulation of dopamine activity is critical in our everyday life with regard to both movements and mood, to which the striosomes contribute,” says Sten Grillner, a professor of neuroscience at the Karolinska Institute in Sweden, who was not involved in the research.

Another possibility the researchers plan to explore is whether striosomes and matrix cells are arranged in modules that affect motor control of specific parts of the body.

“The next step is trying to isolate some of these modules, and by simultaneously working with cells that belong to the same module, whether they are in the matrix or striosomes, try to pinpoint how the striosomes modulate the underlying function of each of these modules,” Lazaridis says.

They also hope to explore how the striosomal circuits, which project to the same region of the brain that is ravaged by Parkinson’s disease, may influence that disorder.

The research was funded by the National Institutes of Health, the Saks-Kavanaugh Foundation, the William N. and Bernice E. Bumpus Foundation, Jim and Joan Schattinger, the Hock E. Tan and K. Lisa Yang Center for Autism Research, Robert Buxton, the Simons Foundation, the CHDI Foundation, and an Ellen Schapiro and Gerald Axelbaum Investigator BBRF Young Investigator Grant.

[justinspoliticalcorner]

Eric Hananoki at MMFA:

Since the Supreme Court overturned Roe v. Wade in 2022, news outlets have published numerous stories documenting how restricted abortion access has medically harmed women across the U.S. In contrast, numerous groups involved with Project 2025, including lead organizer The Heritage Foundation, have falsely claimed over the years that abortions are never medically necessary.  The Associated Press reported that doctors have said “that there are many circumstances in which abortion — meaning the termination of a pregnancy — can be medically necessary,” and AFP wrote that “the scientific consensus” is “that abortion is sometimes medically necessary.” 

Since Dobbs, media outlets have also highlighted cases where state abortion bans have caused significant medical issues.  ABC News talked to “18 women from across 10 states who say their medical care was impacted by abortion bans -- bringing some of them to the brink of death.” ProPublica reported on how doctors “say they can’t give women potentially lifesaving care.” The Washington Post “found that many hospitals have failed to provide specific guidance or policies to help doctors navigate high-stakes decisions over how to interpret new abortion bans — leading to situations where patients are denied care until they are on the brink of permanent injury or death.” And the AP reported this week on how “abortion bans complicate risky pregnancy care.”  Media Matters has documented how Project 2025 seeks to significantly restrict reproductive rights in the country. Multiple Project 2025 partners have also continued to signal that they want to criminalize abortion.

Many groups that are in partnership with Project 2025, such as Susan B. Anthony Pro-Life America, Family Research Council, American Family Association, and lead sponsor Heritage Foundation, have all pushed anti-abortion misinformation falsely claiming that abortions are never medically necessary.

[wr1t3w1tm3]

I did this instead of studying ya'll.

[bengals-ix]

Polo Joe is just 🤤

[zombiedcattle-art]

starvetober day 5: cycle

this one was inspired by the original game jam prototype for dont starve, i recommend checking it out! its pretty neat to see what the game evolved from :]