#fda approved weight loss drug

[total-compounding-pharmacy]

Semaglutide: Shaping the Future of Obesity Management! Dive into a world of innovation and personalized care on your wellness journey. Discover the transformative power of Semaglutide for a healthier, happier you!

[undead-moth]

All of these drugs reduce appetite, not just topiramate. They’re advertising the first two as though they’ll cause weight loss through another means but it’s not true. All three will make you lose weight by dulling your hunger cues, leading you to not eat enough. It’s no different than calorie restriction, and not any more effective than calorie restriction either.

So I was scrolling and I uh. Got this ad.

Which like... ugh, you know? Like I really thought we were moving past this as a society but whatever we've just rebranded the same old diet culture to... whatever this is. And I was ready to move on with my life, but then I thought: I thought there weren't any drugs specifically fda approved for weight loss? And then I recognized "bupropion" (aka wellbutrin) and sure enough, upon a closer look,

Huh??? The topiramate one is especially egregious because what they're advertising it for (lowering appetite) isn't even related to what it's approved for (seizures and migraines).

This like... can't be legal, right? Like, something about this is definitely illegal? I mean it's for sure unethical but aren't there laws about this shit?

And the annoying thing is, when this DOES get shut down, it's going to make it harder for people who DO need these medications to get them and add more hoops to jump through, the same way that when Cerebral got cracked down on, it became like ten times harder for me to get my adderall prescription. Son of a bitch. Every doctor involved in this sham should be fucking ashamed of themselves.

@whatbigotspost

[transmutationisms]

Do you have a perspective on why stimulants aren’t currently widely prescribed as weight loss drugs? Im guessing it’s related to it being a ‘controlled substance’ and ‘scary drug’ but drug marketing in pursuit of pharmaceutical profits is pretty powerful… I wonder why I haven’t seen (effective?) efforts to try to ‘overhaul’ the image of stimulants as only associated with “addiction”, “hyperactive children”, finance bros, and “lazy adults”.

I know vyvanse is also prescribed for binge eating but I get the sense most people are unaware of that. I tried many stimulants and I had the most rapid and “easy” (found food repulsive) weight loss on vyvanse. Granted all of the many prescribed stimulants I’ve tried all greatly suppress my appetite.And I’ve seen it described as a benefit by some people who have it prescribed for adhd (I understand why people do and I sometimes see it as a very depressing benefits because lack of food security despite). Binge eating disorder and prescribing for general weight loss aren’t too far from each other in the fatphobic society we live in but I guess I’m curious how it hasn’t had the ozempic treatment already/ when will it happen. People already look down of folks who can’t function by society’s standards in certain contexts and I see that similarity in how people talk about people who take ozempic for weight loss (admonishing and a moral failure).

stimulants absolutely still are prescribed for weight loss lol, in addition to Vyvanse for 'binge eating' (v unreliable diagnosis that many people receive when they are in fact dealing with subjective loss of control around food as a direct result of restrictive behaviours...) there's also Desoxyn (methamphetamine) and Phentermine (a substituted amphetamine), which are both still FDA-approved for short-term weight management. and yes that's Phentermine as in half of fen-phen. you also have to keep in mind that off-label prescribing is hard to track but is probably still occurring at not-insignificant rates (i know it happens with Ephedra and Clenbuterol, for example). and then there are also patients who use stimulants for weight loss without a doctor's knowledge, either by obtaining them on the black market or by simply getting a doctor to prescribe them for something else.

anyway in regards to pharma marketing strategies i think there are a few things going on here:

weight loss has never actually been the sole market for these drugs, nor was it the first. amphetamine was first synthesised in 1929; it was put into asthma inhalers almost immediately and by the late 30s was being sold as a kind of generalised wellness-producing drug, used by, for instance, college students as a 'pep pill'. the Allies used quite a bit of amphetamine in WWII to keep soldiers alert (the US military was still doing this in Iraq and Afghanistan in the 2000s; afaik they have not stopped this practice). by the late 50s stimulants were also marketed as pick-me-ups for unhappy housewives and for a dizzying array of depression 'subtypes' (postpartum, old age-related, disability-related) and 'modern miseries' (atomic anxiety, economic and political unrest). it wasn't until the 50s and 60s that stimulants really started to be marketed as diet pills, with 'overeating' configured as a symptom of depression. even those formulations also had other use markets: professional athletes, for example. i'm sure pharma companies would love to have the stimulant dominance they once did in weight loss, but it's not really necessary in order to move product: these days the ADHD diagnosis will generally do the job just fine. nicolas rasmussen's book On Speed has more on this history.

speaking of the ADHD diagnosis, i have observed that in the last two or so decades, it has increasingly been invoked in bioessentialist narratives of either 'chemical imbalances' (usually dopamine, norepinephrine) or distinct 'neurotypes' that are said to cause, worsen, or be susceptible to 'overeating', which can therefore be treated by the use of stimulant drugs. i strongly suspect an effect here is that 'overeating', weight gain, or 'obesity' are de facto being used as diagnostic criteria for ADHD, or for other psychiatric diagnoses considered to have high overlap in behavioural presentation. this is not dissimilar to the formulation in the 60s of 'overeating' as a result of depression; in both cases the narrative elides the appetite-suppressant effects of stimulants and presents them as aiding with weight loss by treating an underlying bio/psychiatric pathology. an interesting historical note here is that Adderall is simply a rebrand of the second-gen formulation of the weight-loss drug Obetrol.

presently, weight loss is largely marketed using the language of health rather than aesthetics. although pharma companies are certainly not morally above lying, i do think it would be a tough pill to swallow (pun intended) if they tried to convince anyone that a stimulant prescription is part of this sort of 'wellness' scene. that could change in the future, ofc; these perceptions and associations are socially and historically contingent. in the US even as recently as the 90s, people were definitely still presenting fen-phen as health-promoting (tautologically, because it caused weight loss!), at least until the valve disease scandal.

glp-1 agonists like ozempic are, i think, getting a lot of extremely credulous coverage, from both the medical establishment and health journalists, that is obfuscating the fact that they basically also work by suppressing the appetite. whether it is 'healthier' to do this with a substance that alters endocrine function than to do it with a substance that acts on adrenergic receptors is unclear to me. certainly there are many 'side effects' of the glp-1 agonists that are simply the results of rapid / significant weight loss (fatigue, weakness, osteoporosis, hair loss, gallstones, 'ozempic face', &c). that a process that causes these things can be marketed as health-promoting is a whole other topic lol. but i think the perception of the glp-1 agonists as healthful weight-loss agents has to do with certain misunderstandings of diabetes, metabolism, and body weight, as well as a degree of... not quite blackboxing, but something adjacent, on the part of pharma companies in their promotional materials. which is to say, it wouldn't surprise me if, in the future, people looked back at glp-1 agonists as also being risky drugs to use for weight loss, and only being worth using in specific, limited circumstances.

[blogging1202]

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1

L-Theanine

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2

L-Carnitine

This ingredient, known as L-Carnitine, is an FDA-approved drug that assists in weight loss, promotes heart and brain health, and enhances overall well-being. Additionally, L-Carnitine provides various other health benefits, including regulating blood glucose and sugar levels, enhancing insulin sensitivity, reducing oxidative stress and inflammation. It can also help alleviate symptoms of insomnia, nervousness, muscle fatigue, and thyroid issues.

3

Chromium

This essential trace mineral, chromium, plays a crucial role in the body by enhancing lipid metabolism, as well as processing and synthesizing proteins and carbohydrates. It also improves insulin sensitivity. Numerous studies have demonstrated that supplements containing chromium can assist individuals in managing type 2 diabetes and insulin resistance. As highlighted in the SDGLN Java Burn review guide, chromium works naturally in the body to reduce body weight by breaking down fat.

4

EGCG

Epigallocatechin gallate, known as EGCG, is a plant-based compound that reduces inflammation, supports weight loss, and fights chronic diseases. Studies indicate that epigallocatechin gallate protects you from cell damage and oxidative stress. It even helps increase metabolic function and lower the risk of heart disease.

5

Chlorogenic Acid

Chlorogenic acid is rich in anti-inflammatory, anti-diabetic, anti-carcinogenic, and anti-obesity properties. It even supports preventing and fighting chronic diseases. Many studies on chlorogenic acid have shown that it helps lower glucose and insulin spikes right after food intake which results in a healthy way of losing weight. With the right amount of chlorogenic acid, you can lose more weight because it helps your body absorb less sugar.

6

Caffeine

Caffeine has been proven to boost the metabolic rate, making weight loss more achievable. Research indicates that caffeine has the potential to elevate the resting metabolic rate (RMR), which is the rate at which the body burns calories while at rest. A study published in the National Library of Medicine demonstrated that caffeine consumption increases fat burning in obese individuals. Additionally, caffeine aids in regulating blood sugar levels, enhancing brain function, improving memory, and potentially combating Alzheimer's and Parkinson's disease.

[dhaaruni]

Remember when people screamed at me for pointing out that weight loss drugs could have unforeseen and debilitating side effects even if they're FDA approved? Look who was just proven right.

[grits-galraisedinthesouth]

Royal watchers who labeled Meghan Markle "Ozempic Meg" were on to something.

NOprah's WeightWatchers purchased obesity drug semaglutide and is directing clients to their own telemedicine company for prescriptions.

One of the controversial things about this drug, though, is that a lot of people who are trying to get it don't necessarily medically qualify for it and they just want it so that they can get skinny. How is Weight Watchers going to deal with that?

Weight Watchers has recently moved into the obesity drugs market with the purchase of semaglutide, which works by helping the pancreas release insulin to move sugar from the blood into body tissues, slowing down movement of food through the stomach and curbing appetite. Ozempic and Wegovy are brand names for semaglutide.

Ozempic is approved to treat Type 2 diabetes in adults while Wegovy is approved for weight loss in two groups: those 12 and older with obesity and adults who are overweight and also have least one weight-related health condition, such as high blood pressure or cholesterol.

for the longest time, its whole kind of reason for being is to help people control their eating and up their fitness, and now they are getting into a medical approach to it, and that is a big shift.

Ryan Knutson: Is it possible that these drugs could just be another fad?

Andrea Petersen: I haven't heard that from anybody I've talked to. I think people do believe that this is a significant scientific advance and that it marks a real shift in the treatment of obesity.

Ryan Knutson: Welcome to the Journal, our show about money, business, and power. I'm Ryan Knutson. It's Tuesday, March 14th. Coming up on the show how a new class of drugs is revolutionizing the weight loss industry. For decades, Weight Watchers was one of the most popular ways for people to lose weight. And they did it by pushing lifestyle changes. The company has weigh-ins, branded food, and a famous point system.

Andrea Petersen: What they've done is they've assigned a point value to many, many, many foods. I mean most foods that you can think of. And you are given a certain number of points that you can use each day. And so you decide how you're going to spend those points. And the goal is to stay within that number of points to sort of achieve your weight loss goals.

Ryan Knutson: How has Weight Watchers' business been doing in recent years?

Andrea Petersen: They have been struggling. It's been a sort of turbulent time at the company. So in 2018, Weight Watchers actually really shifted away from this tight focus on weight loss. They actually changed their name to WW. And they largely stopped using the word diet and they tried to refocus their mission as being sort of more broadly about wellness. They also launched and scaled back a number of initiatives. They tried kind of personalized diet plans that many members found pretty confusing and also harder for members to talk to each other and about their experience because everyone was sort of on a different plan and so the kind of community support and sharing recipes and tips and tricks was really not working as well. And also their stock price has really struggled, and their membership has been down. They just reported their fourth quarter earnings, and the number of subscribers slid to 3.5 million from 4.2 million in the year ago quarter.

When I look around this room, I can't help but wonder, is Ozempic right for me?

Andrea Petersen: A lot of celebrities started saying that everyone they know is on it. One of my colleagues did a story about how it was really the talk of the Hamptons over last summer. So it seems to have just really entered the cultural conversation.

Ryan Knutson: Andrea says that some people have been using the drugs who don't meet the FDA's guidelines for it.

Andrea Petersen: These drugs are not for people who need to lose 10 pounds. I mean, these are really, the clinical indication, the FDA approval for Wegovy, which is the drug for obesity, indicates that the drug's for people with a BMI of 30 or more, or a BMI of 27 or more, plus at least one weight related condition such as high blood pressure, high cholesterol, or type two diabetes.

Ryan Knutson: The CDC says a healthy BMI is between 18 to 24. The company that makes both these drugs, Novo Nordisk, said it complies with the law and doesn't condone off-label use. And that, "We trust that healthcare providers are evaluating a patient's individual needs in determining which, if any, medicine is right for that particular patient." This drug sounds revolutionary, but are there potential downsides?

Andrea Petersen: Well, I mean, there's definitely side effects. The most common side effects are things like nausea and vomiting. The FDA approval does note a potential increased risk of thyroid cancer. And then anytime there's a new drug on the market, sometimes it takes a while for us to know what some of the longer term side effects are. That's an issue with any medication. Sometimes you just don't know until things are on the market for several years.

Ryan Knutson: Despite the unknowns, a bunch of businesses have popped up to connect people with doctors who can prescribe the drugs.

Andrea Petersen: So we've seen this sort of story before. I actually covered Pfizer's Viagra back in the late '90s. I'm dating myself. And I remember you had online companies selling it. You had people who were doctors who were advertising home delivery services.

Ryan Knutson: And the same thing is happening now with Ozempic and Wegovy.

Andrea Petersen: I think anytime there is a drug that is meeting a demand, you get this sort of gold rush mentality. There's going to be people that are trying to meet that demand.

Ryan Knutson: After the break, Weight Watchers gets in on the gold rush. Last year, Weight Watchers got a new CEO, Sima Sistani.

Ryan Knutson: Sequence says it doesn't prescribe the medications to anyone who doesn't meet the FDA's BMI guidelines. Weight Watchers says offering access to the medications is a, "natural next step," and that it's in line with the company's focus on providing science backed weight loss programs.

Andrea Petersen: Talking to Gary Foster, who's the Chief Scientific Officer of Weight Watchers, he was saying that they plan to actually create specific programs for people who are on these medications. So specific sort of Weight Watchers plans, because when you lose this amount of weight, you tend to lose really important muscle mass as well. And there are things that you can do to help counteract that. And so he told me about an emphasis on strength training will be really important for folks on these drugs as well as consuming high protein foods. I mean, these can all sort of help counteract that potential loss of muscle mass. So what they were telling me is that they really see what Sequence offers as an adjunct to their existing services.

Ryan Knutson: One of the controversial things about this drug, though, is that a lot of people who are trying to get it don't necessarily medically qualify for it and they just want it so that they can get skinny. How is Weight Watchers going to deal with that?

Andrea Petersen: I mean, I asked this question. I said, "This is a kind of minefield to walk into." And they told me that they are going to follow the science. They're going to really adhere to the letter of what the clinical indications are. They were very explicit in saying that they do not have plans to offer this drug to people who don't qualify for it. When I talked to Dr. Foster, he said to me, "This is not a drug, we're not going to be prescribing this for people who want to lose 10 pounds before their high school reunion."

Ryan Knutson: Part of me is kind of surprised that these drugs have become so popular because I feel like as a society we have started to really move away from pushing weight loss and moved more toward a culture of body positivity.

Andrea Petersen: Well, I mean, that's the interesting tension. This is an interesting cultural moment in our discussion of weight loss. I mean, this also coincides with, we've had several years of the body positivity movement, that really tried to push back against the kind of shaming around people's bodies and people's weight. But at the same time, there's this really growing understanding that excess weight does have real health implications. And so companies who are in this sort of weight loss business have had to speak to both of these realities, and that can be a tricky thing to navigate.

[infamousbrad]

For over 50 roughly-weekly episodes now, the best freelance journalist on the subject of the "weight loss industry" has been partnered with the best freelance journalist on the subject of shitty scientific methodology and I wish you'd listened to all of their episodes before I recommend this one, because I'm going to have a hard time convincingly explaining just how horrifying it is that for the first time since 2007, the American Academy of Pediatrics has updated their guidelines for what doctors should tell parents who are concerned about their children's weight.

If you had listened to all 55 episodes (so far, including this one, not including Patreon bonus episodes) then the following facts would no longer be controversial for you, because wow does Aubrey Gordon bring the reporting and wow oh wow does Michael Hobbes bring the science, footnotes, methodology reviews, and all.

The evidence that there even is an "obesity epidemic" is startlingly thin, because it turns out that the datasets that we get our historical weight estimates from are tiny and weirdly selective.

It is probably not a coincidence that the moral panic about the so-called "obesity epidemic" began the same year that Weight Watchers was founded, also not coincidentally the same year that the FDA approved the first two "weight loss drugs," both of which were disasters. Nor that virtually all weight-loss "science" is funded by the for-profit weight-loss industry.

Every study purporting to explain why we are putting on weight (assuming we are) has failed replication. It is not simply "calories in, calories out." We are not eating that differently from people in the 1950s, decades before the obesity epidemic. We are not getting perceptibly less exercise.

There are many statistical studies (with astonishingly poorly chosen datasets) showing (surprisingly weak) correlations betwen obesity and ill health, but virtually none of them are designed to even try to determine the direction of causality. For example, it is at least as likely that diabetes causes weight gain as that weight gain causes diabetes.

None of the studies to date have even tried to tease out health effects "caused by weight gain" from "caused by fat shaming and weight discrimination," because we don't even know how to do that.

And most importantly, almost no weight loss studies show their three-year success rate data; when that data has been sought out, all but two have a failure rate in excess of 95%, and the average weight loss per attempt at the three-year mark is a gain of 10 pounds. The other two methods have a success rate of almost 1/3rd, and even for those 1/3rd, an appalling list of high-probability complications.

The one thing that has entirely reliably been proved to cause weight gain is attempting to lose weight.

The American Academy of Pediatricians is recommending that all children with a BMI of 27 or more be offered:

A very expensive six-month "whole health" intervention that has a 1 in 3 success rate, requires the whole family to attend every multi-hour weekly session, and is not covered by any known insurance. And the whole medical field has enough capacity to treat about 350 kids a year. If that is not available to the parents (and it won't be) ...

Children age 8 or above may be prescribed fenteramine, metformin, or semaglutide, all of which have about a 5% success rate, none of which have been adequately tested for long-term safety in children, all of which will have to be taken for a lifetime, all of which are known to cause major rebound weight gain if or when the patient goes off of the drug, and ...

Children age 12 or over may be referred for stomach-reduction surgery. Which does have about a 1 in 3 success rate, but with insanely high complication rate. Even patients who experience weight reduction through stomach reduction have about a 70% regret rate for two reasons: it creates a lifetime of serious health complications like inability to absorb vitamins from your food and extreme vulnerability to alcohol poisoning, and, worse, the weight loss is actually, on average, pretty minimal. It will turn your maybe-sick fat kid into an even sicker slightly-less-fat kid.

The AAP's own introduction to their guidelines admit that they are not seriously addressing the social determinants of health nor any other hypothesis for why your kid might be gaining weight. They also say quite bluntly that they are not even going to address the question of whether losing weight (in the unlikely event it works) will make your kid any healthier.

If these guidelines are followed, the results are going to be catastrophic.

[polypeptide555]

Semaglutide for weight loss - What you need to know

①.What is Semaglutide?

Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that helps to regulate appetite and insulin. It works by stimulating GLP-1 receptors in the brain, which causes the body to feel full after eating smaller portions of food. It also helps reduce fat levels in the body by increasing insulin sensitivity, helping to control blood sugar levels. It is the first FDA-approved drug since 2014 for chronic weight management in overweight adults or adults with general obesity.

②.Here are five reasons to consider semaglutide for weight loss.

1.Semaglutide helps you lose weight gradually and safely.

Semaglutide works by reducing your hunger and cravings by lowering your appetite and slowing down digestion, making it easier for you to stick to a low-calorie diet. It also helps reduce the amount of fat stored in your body, leading to gradual and safe weight loss.

2. Semaglutide can help you keep the weight off.

Unlike other weight loss medications, which only work while they’re in your system, semaglutide has been shown to promote lasting weight loss by helping you stick to a healthy diet and lifestyle even after discontinuing the medication.

3.Semaglutide helps improve metabolic health.

In addition to helping you lose weight, semaglutide also reduces your risk of developing type 2 diabetes by improving your body’s ability to use insulin, as well as reducing inflammation and cholesterol levels.

4.Semaglutide is generally well-tolerated.

Most people who take semaglutide experience minimal side effects, such as nausea, headache, and constipation. The most common side effects are usually mild and can often be managed with lifestyle modifications or over-the-counter medications.

Please click to learn more.https://www.polypeptide.ltd/

[mariacallous]

A revolution in weight loss is apparently underway. It started in 2021, when the FDA approved the diabetes drug semaglutide for weight loss. The weekly injectable—sold under the brand name Wegovy—can help users lose 5 to 10 percent of their body weight, leading commentators to describe the drug as both a “medical breakthrough” and a “silver bullet” for obesity. Elon Musk says he’s taking it, Kim Kardashian is rumored to be using it, and everyone from Hollywood to the Hamptons reportedly wants a prescription. 

Soon, there will be a new weight loss medication on the block—and it’s even more potent than its peers. Last fall, the FDA fast-tracked the review process for using tirzepatide as a weight loss drug after a clinical trial showed that people with BMIs labeled “overweight” or “obese” lost a staggering 22.5 percent of their body weight on the highest dose. If all goes according to plan, that will make Mounjaro the latest in a fast-growing biomedical sector—spanning everything from bariatric surgery to deep brain stimulation for binge-eating—that aims to combat, if not cure, the problem of “excess” weight. 

For pharmaceutical companies, the race to market is financially motivated: Wegovy and Mounjaro cost more than $1,000 a month. Weight loss drugs are rarely covered by insurance, but people who can afford them have proven they’re willing to pay. And the market seems effectively limitless: Despite an ongoing “war on obesity,” more than 1.9 billion adults globally are considered overweight or obese, and the number of prospective users is growing every year. Now doctors—desperate to treat what is widely seen as an “obesity epidemic”—are coming on board. In January, the American Academy of Pediatrics recommended such medications for kids as young as 12. 

The victorious narratives gilding drugs like Mounjaro are already being positioned as a direct challenge to fat activism. For decades, the movement has pushed for social and economic opportunity for people of all sizes through civil rights, fat pride and liberation, and biomedical evidence itself. Thanks to prominent voices like Audrey Gordon and Michael Hobbes, many people now know that “lifestyle changes” like calorie restriction and exercise fail to produce sustained weight loss for 97 percent of people and that many dieters end up gaining back more weight than they lost. But what happens to the strength of these arguments when a weight loss drug seems to work?

Like other purported weight loss solutions, Mounjaro promises “to fix weight stigma by making you thinner, instead of removing the stigma,” says Susanne Johnson, a fat activist and family nurse practitioner in Pennsylvania. In so doing, these drugs and surgeries further exacerbate anti-fat discrimination. Instead of criticizing people in larger bodies for their perceived lack of willpower—that old “calories in, calories out” adage—people can now blame those in bigger bodies for something more akin to a techno-pessimist, or even anti-science, stance: “Just take the miracle cure!” 

The history of the weight loss industry is more akin to prospecting for gold or investing in crypto than transplanting organs and developing antibiotics; less a story of scientific progress than an endless cycle of wild speculation, where boom inevitably gives way to bust. Fen-Phen was a miracle until it was linked to heart valve damage. Intermittent fasting was going to fix what caloric restriction couldn’t until researchers showed the two produce exactly the same results. And then there’s the complicated case of bariatric surgery.

From their inception in the 1950s, operations like gastric bypass (which reroutes food away from the stomach, inducing malabsorption) and gastric sleeve (which involves partially amputating the stomach so it holds less food and produces fewer hunger hormones) have been sold as a potential panacea, says Lisa Du Breuil, a clinical social worker at Massachusetts General Hospital. While fewer than 1 percent of people who qualify actually undergo bariatric surgery, those who do can lose up to 70 percent of their “excess” weight (or the weight above a BMI of 24.9). 

But Du Breuil, who specializes in eating disorders and substance abuse disorders, has seen some of the worst of bariatric’s side effects. People can develop dumping syndrome—wherein sugar-rich meals leave the stomach too quickly, causing sweating, dizziness, rapid heart rate, and vomiting. Gastric bypass in particular raises the risk of postoperative alcohol abuse. Rates of suicide and self-harming behaviors also rise in the years after bariatric surgery. And even when people follow strict post-operative diets, malnutrition, tooth loss, gout, and new or resurging eating disorders are possible. “It can be really challenging to get a full picture,” Du Breuil says. She learns about new side effects all the time.

Semaglutide and tirzepatide—both part of a larger family of GLP-1 receptor agonists—were developed for diabetes management at lower doses. When pharmaceutical companies noticed their trial participants were also losing weight, they realized “if we can turn the volume up to 11, we can really enhance this side effect,” says Johnson, the nurse. “That means you’re also turning up the other side effects.” 

The primary complaints from users of Ozempic, Wegovy, and Mounjaro sound like the kind of thing you can fix with a bottle (or three) of Pepto Bismol: nausea, upset stomach, diarrhea, and what one patient called “power vomiting.” But these might be less like classic “side effects” of a drug than a mechanism of weight loss itself, as The Guardian recently reported. By making the feeling of eating (and, in some cases, even hydrating) actively disgusting to the user, the drug curbs their consumption—similar to the experience of bariatric patients, who can only fit a few ounces of food in their stomachs at a time. 

The list of complications doesn’t end there. For example, both GLP-1 receptor agonists may increase the risk of thyroid cancer—one of the many BMI-linked diseases that supposedly makes weight loss absolutely imperative for people in larger bodies. And there’s good reason to believe that other side effects will reveal themselves in years to come, as the number of long-term users grows. 

The biggest surprise for many prospective patients is that long-term weight loss isn’t guaranteed—a reflection, perhaps, of the faulty assumption that people are obese because they overeat. Current estimates suggest that the average bariatric surgery patient regains 30 percent of the weight they lost in the 10 years after surgery. One in four regain all of their weight in that time. And 20 percent of people don’t respond to surgery in the first place. 

The same is true for GLP-1 receptor agonists: If you stop injecting, the weight returns. 

In case it wasn’t clear by now, biomedical weight loss interventions often mimic the deadly logic of anorexia, bulimia, or other forms of disordered eating, says Erin Harrop, a clinical social worker and researcher. Harrop would know. At the height of their own eating disorder, Harrop wished they could fill their stomach with air instead of food, or cut their stomach out, or wire their jaw shut. Later, they learned these things exist—in the form of gastric balloons, gastric sleeves, and even a magnetic jaw trap. 

It’s no surprise, then, that some people who undergo bariatric surgery experience a resurgence of a preexisting eating disorder, or develop a new one. Frequent vomiting, never knowing what foods will upset your stomach, and feeling pressure to maintain a post-surgical weight—“you can create an eating disorder that way,” Du Briel says.

But semaglutide and tirzepatide promise to fulfill an even stranger fantasy: eliminating appetite itself. While a drug like Mounjaro works on numerous fronts—including preventing the body from storing fat and “browning” existing adipose tissue—it’s the feeling of being untethered from desire that seems to fascinate patients and physicians alike. People for whom the drug works often say, “I forget to eat,” says Fatima Cody Stanford, an obesity medicine specialist at Massachusetts General Hospital’s Weight Center. 

If doctors really believe that obesity is the greater of any two evils, then this approach makes sense. When it comes to bariatric surgery, for example, a review of the medical literature suggests it is, on balance, associated with a reduction in all-cause mortality—or death of any cause*—*compared to patients with high BMIs who don’t go under the knife (though such studies are profoundly limited, as they often do not control for social factors, like income or education). Many hope that semaglutide and tirzepatide will one day prove just as vitalizing.

But eating disorders kill too. In many contexts, sustained hunger is considered a travesty. And desire—for food, or anything else—is a great way to know you’re alive. “It’s wild to me that we see no appetite as a positive thing,” says Shira Rosenbluth, an eating disorder therapist who works with people of all sizes. Anna Toonk agrees: “I realized that there are worse things than being fat,” she told The Cut last fall. “The worst thing you can be is wanting to barf all the time.” 

Ultimately, the proliferation of drugs like Mounjaro means medicine is not only in the business of dictating “normal” weights (a thing it still hasn’t quite figured out), but “normal” appetites. What was once an intuitive process, in which your body tells you what it needs, became a dictate under diet culture: You tell your body what it can have. Now medicine promises a radical reset: With the right drug, your body will hunger for nothing at all.

Weight loss technology can’t be stopped entirely—nor should it be. Everyone has the right to choose what they want to do with their bodies. But informed consent is built on information, and we may not have enough. Mounjaro was fast-tracked by the FDA based on studies designed to observe weight loss over just 72 weeks, a small fraction of the time real patients will be on the drug. At the very least, patients should be informed that in the first years after a drug hits the market, they are participants in an ongoing experiment. 

As biomedicine’s war on obesity continues, people must work harder to combat anti-fat bias—not on a technicality, but as part of the expansive vision of justice fat activists began articulating more than 50 years ago. For semaglutide, tirzepatide, bariatric surgery, and their ilk are neither miracles nor cures. There have always been fat people, and there always will be, whether they’re “non-responders” to treatment, refuseniks, or languishing on the waitlist. Notably, even those who experience dramatic weight loss after surgery or on injectables may still be overweight or obese, depending where they started. 

Perhaps most importantly, the American weight loss discourse must move away from a reflexive scientism, which has enabled biomedicine to subject the entirety of human experience to its single-minded scrutiny. Weight, like almost every aspect of embodiment, is not an exclusively biological phenomenon or a clear-cut medical “problem” to solve. It is shaped by countless factors, like power distribution in society, personal psychology, and that most frightening of forces: the desire for more.

If you or a loved one is struggling with an eating disorder, the National Eating Disorders Association Helpline is available at (800) 931-2237.

[fivehundredwords]

Alzheimer's Disease: biomarkers and neuroimaging markers cheatsheet for research articles

As Alzheimer's Disease (AD) research skews toward understanding the brain than the pathogenic proteins, studies exploring biomarkers and neuroimaging are hopeful toward developing a method for successful prevention of AD. A biomarker is a molecule, whose presence indicates abnormality or disease, and thus, is crucial in diagnostic procedures. Levels of certain molecules is notably altered in cerebrospinal fluid and in blood plasma, which helps in diagnosing the occurrence of AD. Neuroimaging involves the use of techniques such as magnetic resonance imaging and computed tomography to observe neuronal activity in the brain. This is good news, especially for AD, as the asymptomatic stage of the disease can be identified early enough.

Although the exact function and involvement in clinical practice is not profuse, altered concentrations of these biomarkers in plasma or cerebrospinal fluid encourage further research:

Amyloid and tau serve as the unsurprising biomarkers of AD pathology.

Neurofilament-light chain (NF-L) and visinin-like protein-1 (VILIP-1) are the most promising biomarkers of neuronal injury.

Post-synaptic protein neurogranin (Ng) and pre-synaptic proteins synaptosome-associated protein-25 (SNAP-25) and synaptotagmin-1 (Syt-1) are considered major biomarkers of synaptic injury.

Brain and CSF levels of tumor necrosis factor alpha (TNF-α) and increased levels of interleukin group of proteins (ILs) indicate intensified microglial response to neuroinflammation.

TREM2 receptor and YKL-40 glycoprotein are also reliable indicators of inflammation and impaired clearance of amyloid beta.

Heart-type fatty acid-binding protein (hFABP) could be a marker for pathology in blood vessels supplying the brain. Some vascular markers also show potential as markers of vascular injury in AD: von Willebrand factor (vWF) and monokine induced by γ-interferon (MIG, also known as CXCL-9).

Concentrations of TAR-DNA binding protein (TDP-43) in the brain and plasma and serum indicate, even contribute to, inflammation, mitochondrial dysfunction, and neuronal/synaptic injury in AD.

Neuroimaging techniques reveal structural, functional, and diffusion-related activities of the neurons. To identify them, markers are tracked in images obtained. Each marker is determined with the activity and biochemistry of the group of/individual neurons being studied.

Structural MRI will show location and severity of atrophy which can be identified in grey scale images by applying programs that create analogous color grading.

Functional MRI relies on blood oxygenation level dependent (BOLD) signal which reflects changes in blood oxygenation levels in response to neural activity.

Diffusion weighted imaging (DWI) focuses on diffusion of water molecules. A tensor model is applied to images obtained from DWI. The diffusion tensor imaging (DTI) metrics thus obtained help in studying connectivity through structural integrity of white matter tracts.

Tractography involves 3-D reconstruction of white matter as observed in DWI, which provides a more detailed look into a patient’s neural networks.

In positron emission tomography (PET), markers are identified and labelled so their features or functions can be traced during this procedure to obtain a resulting PET scan. The imaging procedure is named according to its marker: amyloid-PET, tau-PET, FDG-PET, inflammation-PET, receptor-PET.

FDA approved drugs Galantamine, Rivastigmine, and Donepezil alleviate symptoms such as memory loss and confusion in mild to moderate AD, although their effects seem to be negligible. They also cause nausea and vomiting as side effects and are not suitable for every patient. Recently approved drugs, Aducanumab and Lecanemab focus on removing accumulated amyloid. Their effectiveness is still doubted on the basis of studies finding that targeting amyloid has little to do with curbing the actual progression of the disease.

bibliography -

Tarawneh R. Biomarkers: our path towards a cure for Alzheimer disease. Biomarker insights. 2020 Nov;15:1177271920976367.

Cavedo E, Lista S, Khachaturian Z, Aisen P, Amouyel P, Herholz K, Jack Jr CR, Sperling R, Cummings J, Blennow K, O’Bryant S. The road ahead to cure Alzheimer’s disease: development of biological markers and neuroimaging methods for prevention trials across all stages and target populations. The journal of prevention of Alzheimer's disease. 2014 Dec;1(3):181.

Medications for Alzheimer's Disease Stanford Healthcare. Accessed 21-04-2023.

[darilto-blog]

Resurge Supplement Reviews-Resurge Supplement Ingredients

Resurge The Godzilla Offers is a blend of natural products that are useful for losing weight, increasing metabolism, boosting the immune system and relieving stress.

Fight against problems that in one way or another are related to weight gain. It is manufactured in the USA and approved by the Food and Drug Administration FDA.

Resurge is made with all-natural products encapsulated in easy-to-swallow vegetarian capsules. The synergistic effect of all the ingredients combined is immense as the properties of each one are focused on the objective, to help you get a deep sleep. The ingredients used are:

Melatonin: Helps you fall asleep faster and stay soundly asleep for longer as a child.

Ashwagandha: Helps reduce stress and anxiety and induces a more relaxed state.

Hydroxytryptophan: improves the effect of melatonin for deep sleep.

L-Theanine: improves deep sleep while reducing anxiety levels and relaxing the resting heart rate.

Magnesium and Zinc: The combined effect of the formula helps improve the quality and ease of sleep, as well as morning alertness.

Arginine and Lysine: These ingredients help increase HIGH levels in the body, stimulating the regeneration process that occurs during deep sleep.

All of the above ingredients have their own special powers to restore sleep, burn fat, activate metabolism and the immune system, reverse aging, and heal the body in general. However, the Resurge weight loss supplement that is sold to today's customers is a much more evolved version.

Resurge customer review reveals that users were indeed very satisfied.

According to Daily Wellness Pro, Resurge pills have one simple goal, to speed up metabolic function. This is crucial because your metabolism slows down as you age. This lazy metabolism can't burn fat at the proper rate, which is what leads to weight gain in the first place, as well as causing all the difficulty in getting rid of those extra pounds.

When the fat you eat doesn't melt, it accumulates into reserves that your body can be proud of. Obviously, this accumulated fat is nothing if not difficult to eliminate. Likewise, slow digestion is slow when it comes to consumption and the new fat you ingest.

To solve this problem, this supplement works to speed up your metabolism to the ideal level. This encourages weight loss as your body begins to burn fat naturally. Slowly, as these piles of fat melt away, you will begin to notice an improvement in your weight.

Optimal metabolism also makes you more active as all bodily activities speed up. Fat melting also improves your energy levels, which can be considered another benefit of active metabolism thanks to this supplement.

If you're looking for a better night's sleep, don't waste time.

Access the official website link in the description of this video and in the first comment and guarantee your Resurge right now!

[usfreehealthcare]

side effects of losing weight too fast

Lose 10 kg in 10 days! You can eat as much as you want and still lose weight! Size down in 1 day! If you believe the advertising, you can lose weight quickly. Trending diets and nutritional supplements for weight loss promise slim bodies in no time. Most consumers spend $33 billion annually on weight loss products. Do any of these products really cause rapid weight loss? Is it safe to ingest? And what are the dangers of losing weight too quickly? Here's a look at some quick weight loss claims and the available evidence.

What is Fast Weight Loss?

Many sellers promise "quick weight loss," so it's hard to categorize them all.Most quick weight loss methods fall into the following categories. Tablets and Dietary Supplements Dozens of diet supplements promise to accelerate weight loss. In general, they claim to inhibit nutrient absorption, increase metabolism, or burn fat. Very Low Calorie Diet (VLCD) One of the most proven methods for rapid weight loss is the Physician-Supervised Very Low Calorie Diet (VLCD). Most of the information we know about rapid weight loss comes from studies of people following these diets. worms, gadgets, magic There seems to be no end to the questionable ideas being promoted in the name of rapid weight loss. Most of them promise to replace diet and exercise.

Does Fast Weight Loss Work?

The US Food and Drug Administration (FDA) regulates dietary supplements. However, treat it like food rather than medicine. The FDA also does not review claims made by over-the-counter weight loss products. Unlike pharmaceutical manufacturers, dietary supplement manufacturers do not have to prove the safety or efficacy of their products before marketing them. This means that dietary supplements do not have to be approved by the FDA before being placed on the market. Other than very low calorie diets and weight loss surgery, no other product, pill, or diet has been proven to result in rapid weight loss. It is not intended for serious weight loss and may have side effects.In a fast weight loss program, it is not pills or some kind of food that burns fat, but the drastic reduction in calories associated with exercise.

What are the dangers of rapid weight loss?

Rapid weight loss causes physical stress on the body. Possible serious risks include: Gallstones occur in 12-25% of people who lose a lot of weight in a few months. Dehydration can be prevented by drinking plenty of water. malnutrition. It is usually caused by not eating enough protein for several weeks. An electrolyte imbalance that is rarely life threatening. Other side effects of rapid weight loss are: headache hypersensitivity and irritability Malaise dizzy constipation Irregular menstruation hair loss muscle breakdown The risk of rapid weight loss increases with the length of the diet. A diet without protein is very dangerous.

Is rapid weight loss always a bad idea?

Crash diets can have adverse effects, but so can obesity. Therefore, a very low calorie diet (VLCD) is recommended for those who are overweight (Body Mass Index (BMI) greater than 30) and who do not have specific goals such as exercise. A good choice for those who need to lose weight quickly because of such as weight loss surgery. Consider weight. VLCD is a medically controlled diet that lasts for several weeks. Diets are nutritionally balanced but expensive - people end up spending thousands of dollars. VLCD reliably reduces weight by 15% to 25% in 12 weeks. This is for those who have completed the program. 25% to half of people fail to complete the program. If you stop dieting, your weight will return to where it was before, but this will happen quickly. Some experts say it's better to use sustainable approaches to weight loss than conventional diets. Of course, most people who want to lose weight quickly usually do so on their own.Often the goal is to achieve a short-term goal. B. Reach your dress size or look good on the beach. Starving is definitely not a good idea. However, if you are medically fit, there is no harm in doing short-term, severe calorie restriction. You should tell your doctor what you are doing and make sure you are getting protein in your diet (70-100 grams per day). Take a multivitamin and eat foods high in potassium (tomatoes, oranges, bananas). Also remember that crash diets rarely help you maintain a healthy weight. Most people will put the weight back on quickly. Read the full article

[snoash]

Unanswered Questions Into Semaglutide Revealed

Semaglutide is really an injectable medications utilized to benefit handle sugar levels are regulated in adults with the help of type 2 diabetes. It operates by enhancing the total body manufacture extra insulin shots and by lowering the sum of sugars a poorly liver digests. It is usually using a class of prescription drugs identified as GLP-1 receptor agonists. Semaglutide may additionally lessen the likelihood of having heart attacks or just working with a strokes. Numerous studies have established that when they are treated when each week, semaglutide significantly lowers A1c stages. And also, experts have demonstrated to decrease weight and also raise cardiometabolic risk factors (for instance hips area, systolic and even diastolic high blood pressure, full bad cholesterol, low-density lipoprotein, combined with very-low-density lipoprotein high levels of) through individuals with sort 2 diabetes.

A deteriorated form of prescription drugs is on the market because Ozempic and Wegovy and allows long been sold to make sure you customers on the FDA’s pharmaceutical rarity product. A FDA has gotten unfavorable incident stories from the by using this method deteriorated pill. Customers should apply FDA-approved meds who were checked out regarding basic safety, efficiency, or high quality. Semaglutide is discovered to always be well-tolerated and it was safe and effective the instant shot via medical professionals from the subcutaneous (under the skin) or perhaps even 4 (into a vein) injection sites. Often, these injection blog really should be adjusted at least each and every week combined with which is injected in the completely different part whenever to prevent condition. If the online searchers make use of website over the internet, they will receive info about semaglutide weight loss .

While having your treatments, brows through the semaglutide product when each and every one injection in order that it actually is distinct or clear and exempt from allergens. Avoid using it all when it is dyed, overcast, thickened, as well as provides good allergens or maybe that expiration particular date has gone. Equally, fail to income for selling typically the fine needles or simply injector write and throw away these individuals accurately inside the pierce protection fish tank. Quite a few normal side effects from semaglutide can include nausea, vomiting, stomach pain, diarrhea, and constipation. A majority of these secondary effects traditionally fail to last and definately will depart since your body adapts into the medicine.

In advance of utilizing semaglutide, inform your doctor for anyone who is dyspathetic to it an additional medicinal drugs. Equally, educate your medical physician and additionally pharmacologist what recommended and even nonprescription medicinal drugs, multi-vitamins, vitamins and minerals, and additionally herbal products you're or possibly need to use. It is very important figure out if one has kidney, liver organ, or perhaps even gall bladder problem; and / or pancreatitis (inflammed joints of an pancreas). Physician might not always designate semaglutide for people who have most of these ailments. Lastly, inform your physician in case you are mothers-to-be and even breastfeeding. It's not acknowledged detail prescription drugs will definitely move through bust get probably it will injuries a toddler.

Decide to purchase true Semaglutide protein powder 5mg & 10mg is a new once-a-week injectable prescription drugs that's given by doctors to attend to adult onset diabetes and also weight problems. Effect patients get rid of fat by lessening their cravings along with resulting in the body to get rid of excessive fat to obtain utility. All the once-a-week serving of one's prescription drugs likewise helps clients feel comprehensive when dishes, causing not as much total food intake. The medication is a kind of GLP-1 receptor agonist and he has also been agreed upon used by the FDA with people that have weight problems and type 2 diabetes to assist them drop a few pounds. It functions by mucking up creating ghrelin, a fabulous bodily chemical in which opinions for food craving, and with reducing the measure of sweets within the body. In addition to proper diet and physical activity, the actual meds can aid weighty patients generate noticeable fat loss without the need for obtrusive surgery. To understand your course of this semaglutide buy , customers could possibly make reference to this particular weblink .

[lindamarry1]

Exploring the Effectiveness and Safety of Weight Loss Medications: A Comprehensive Guide

In today's world, where obesity has become a global epidemic, weight loss medications have gained significant attention as a potential solution. These medications, when used in conjunction with a healthy lifestyle, can assist individuals in achieving their weight loss goals. This comprehensive guide aims to provide an in-depth analysis of the effectiveness and safety of weight loss medications. As we delve into the topic, we will also shed light on Mounjaro weight loss, a reputable website that offers weight loss medications. 

Understanding Weight Loss Medications 

1.1 Defining weight loss medications

Weight loss medications, also known as anti-obesity drugs, are prescription or over-the-counter medications designed to aid in weight reduction. These medications can be categorized into different types based on their mechanisms of action, such as appetite suppressants, fat absorption inhibitors, and metabolic enhancers.

1.2 Common types of weight loss medications

Some common weight loss medications include phentermine, orlistat, liraglutide, and bupropion/naltrexone. Each medication works differently to help individuals lose weight, whether by reducing appetite, blocking the absorption of dietary fat, or influencing metabolism.

1.3 How weight loss medications work in the body

Weight loss medications target various aspects of the body's physiology to promote weight loss. They may act on the brain to suppress appetite, affect the digestive system to inhibit fat absorption, or impact metabolism to enhance calorie burning.

The Effectiveness of Weight Loss Medications

2.1 Clinical Studies and Evidence

Numerous clinical studies have evaluated the effectiveness of weight loss medications. These studies often compare the outcomes of individuals using medications versus those following a placebo or non-medication intervention. The results show that weight loss medications can lead to greater weight loss compared to lifestyle changes alone.

2.2 Average weight loss with medication

The average weight loss achieved with weight loss medications varies depending on the specific medication and individual factors. However, studies have shown that individuals using weight loss medications, in combination with a reduced-calorie diet and increased physical activity, can expect to lose 5% to 10% of their initial body weight over a period of several months.

2.3 Factors influencing effectiveness

2.3.1 Individual response

The effectiveness of weight loss medications can vary among individuals. Factors such as genetics, metabolism, underlying medical conditions, adherence to medication, and lifestyle changes can influence the degree of weight loss achieved.

2.3.2 Adherence to medication and lifestyle changes

The success of weight loss medications is closely tied to an individual's adherence to the prescribed regimen. Consistently taking the medication as directed, following a balanced and calorie-controlled diet, and engaging in regular physical activity are essential for optimizing the effectiveness of these medications.

Safety Considerations of Weight Loss Medications 

3.1 Regulatory Bodies and their role

Before weight loss medications are approved for public use, they undergo rigorous evaluation by regulatory bodies such as the Food and Drug Administration (FDA). These agencies assess the safety and efficacy of the medications based on data from preclinical and clinical trials.

3.2 Common side effects of weight loss medications

Weight loss medications may cause side effects, which can vary depending on the specific medication. Common side effects include nausea, diarrhea, constipation, dry mouth, dizziness, and insomnia. These side effects are generally mild and diminish over time as the body adjusts to the medication.

3.3 Potential risks and precautions

3.3.1 Interactions with other medications

It is crucial to consider potential interactions between weight loss medications and other medications an individual may be taking. Some weight loss medications may interact with certain antidepressants, antidiabetic drugs, or other medications, leading to adverse effects or reduced efficacy.

3.3.2 Allergies and contraindications

Individuals with known allergies to specific weight loss medications should avoid using them. Additionally, weight loss medications may be contraindicated for individuals with certain medical conditions, such as uncontrolled hypertension, heart disease, or a history of substance abuse.

3.3.3 Long-term safety concerns

Since weight loss medications are relatively new, their long-term safety is still being studied. It is important to discuss any concerns or potential risks with a healthcare professional before initiating a weight loss medication regimen.

Mounjaro Weight Loss: A Reliable Source for Weight Loss Medications 

4.1 Introduction to Mounjaro weight loss

Mounjaro weight loss is a reputable website that offers a range of weight loss medications. They provide a convenient and reliable platform for individuals seeking medically approved weight loss options.

4.2 Safety Standards and quality control

Mounjaro weight loss adheres to strict safety standards and ensures that all medications available on its platform are approved by regulatory authorities. They source their medications from trusted manufacturers and regularly monitor product quality.

4.3 Available weight loss medications and their effectiveness

Mounjaro weight loss offers a variety of weight loss medications, each with its unique mechanism of action. The website provides detailed information about the medications they offer, including their effectiveness, potential side effects, and usage instructions.

4.4 Customer Testimonials and Reviews

Mounjaro weight loss features customer testimonials and reviews, allowing individuals to gain insights from others who have used their services. These testimonials can provide valuable information about the effectiveness and customer satisfaction associated with the weight loss medications offered by Mounjaro.

Lifestyle Changes and Weight Loss Medications 

5.1 Importance of lifestyle modifications

While weight loss medications can be effective, they should be used as part of a comprehensive weight management approach that includes lifestyle modifications. Adopting healthy eating habits, engaging in regular physical activity, managing stress, and getting adequate sleep are crucial for long-term weight management.

5.2 Synergy between weight loss medications and lifestyle changes

Weight loss medications can complement lifestyle changes by providing additional support for appetite control and metabolic regulation. When used in combination with a healthy lifestyle, these medications can enhance weight loss outcomes.

5.3 Incorporating Diet and Exercise for optimal results

To maximize the benefits of weight loss medications, individuals should follow a well-balanced, calorie-controlled diet and engage in regular physical activity. A healthcare professional or registered dietitian can provide personalized guidance and support in developing a suitable diet and exercise plan.

Choosing the Right Weight Loss Medication 

6.1 Consultation with healthcare professionals

Before initiating any weight loss medication, it is important to consult with a healthcare professional. They can assess individual needs, consider medical history, and provide guidance on choosing the most appropriate medication based on effectiveness, safety, and potential interactions.

6.2 Assessing individual needs and Goals

Weight loss medications should be tailored to individual needs and goals. Factors such as weight, overall health, medical conditions, and lifestyle should be taken into account when determining the most suitable medication.

6.3 Considering the medical history and potential contraindications

Individuals with certain medical conditions, such as cardiovascular disease, diabetes, or kidney problems, may require specific considerations when selecting a weight loss medication. A thorough assessment of medical history is essential to identify potential contraindications and ensure the chosen medication is safe to use.

Conclusion 

In conclusion, weight loss medications can be valuable tools in the journey toward achieving a healthy weight. They can provide an additional boost when combined with lifestyle changes such as a balanced diet and regular exercise. However, it is essential to recognize that weight loss medications are not a one-size-fits-all solution, and careful consideration should be given to safety, effectiveness, and individual circumstances. Mounjaro weight loss stands as a trusted website offering a range of weight loss medications, but it is always advisable to consult with healthcare professionals before starting any medication regimen. By understanding the effectiveness and safety of weight loss medications, individuals can make informed decisions to support their weight loss goals and improve their overall well-being.

[moldybits]

I need to bitch for a minute here so hold on a sec

I understand most people don’t understand how pharmacies work. I don’t think corporations adding in things like drive thrus has helped retail pharmacy’s image either. But holy shit, this video (and especially the comments) fucking infuriate me

First off, I want everyone to know, a pharmacist has the 100% legal right to not fill your prescription for any reason. Now, normally when there is an issue with the prescription, the pharmacist will attempt to contract the prescriber to have something fixed, changed, clarified, etc. Rarely will a pharmacist ever outright refuse a prescription. I’ve seen it happen only a few times- and those few times came with good reasons. Remember, this is their license on the line. If they were to allow a prescription to get filled that could hurt or even kill you, and something did happen to you, then legal authorities come back at the pharmacist first for allowing it to be dispensed. I hate seeing comments like “this is between me and my doctor!!”. Your pharmacist knows more about medications and drug interactions than your prescriber. Your pharmacist is a healthcare professional. For the love of god they’re not fucking fast food workers that stand around and approve every medication they see.

Second, also in response to the comments, if you’re gonna complain about HIPAA, you better at least spell it right. It isn’t “HIPPA” 🙄. Anyway, yes a pharmacist can ask you any medical question they’d like. I can ask you any question I’d like as a pharmacy tech! I just can’t take your medical information and just tell the next random person in line. That is what HIPAA is. We’ve had a woman complain in the pharmacy that asking for her birthday- which is how we look up your medication in the first place- is a violation of HIPAA. It’s fucking not.

In response to the video- no one refused to fill the prescription. What most likely happened is this: Mounjaro is currently only FDA approved for type 2 diabetes. Not weight loss. Insurance rarely covers Mounjaro anyway. Won’t cover it at all for weight loss. There is a manufacturer discount card that can bring it down to $25 (this has changed). In order to bill the discount card, it basically needs to be billed thru insurance first, then be rejected, then billed thru the discount card which would usually bring it to the $25. They changed this for the new cards. Because of auditing, it now only covers the prescription if there is a type 2 diagnosis on the prescription. It will not cover it without it. So what probably happened is that the pharmacist tried to contact the prescriber for a diagnosis when the discount card didn’t go through, the provider didn’t get back to them, so they’re asking the patient (which they can legally do!) if they are using it for weight loss or diabetes. If course, a chain retail pharmacy can fill it for cash, if you’re willing to pay over $1000 out of pocket for it. Which I doubt the patient being mentioned in this video wanted to do. I specify chain pharmacy btw, because an independent might out right refuse to fill it solely based on profit alone. What if they order in Mounjaro, which has a huge cost, and you say you’ll pick it up for cash, but you never do? Now that pharmacy is out major $$$. Not as big of a deal for chain pharmacies, but it can hurt an independent. At the end of the day though, it wasn’t a refusal to fill, it just wasn’t covered and the patient didn’t want it. I’m sure had this woman just called and asked the pharmacist would’ve told her that. 

I do have 1 final point though. I’d like to point out this woman is a NP- Nurse Practitioner- and NOT a doctor. I know a lot of people don’t know the difference between PA/NPs and actual doctors, but I can’t emphasize enough that while she can diagnose and treat, she did NOT go to an actual medical school a doctor went to. Looking at her profile, she works at a place called “Lotus Healthcare and Aesthetics”, which while they say they offer physicals and vaccinations… it seems to me they focus heavily on “beauty and aesthetics” such as spray tanning and lash extensions…. Ya know, real medically important shit. If you wanna learn more about this shit just look over at r/Noctor and you’ll see what I mean

I’m not shocked this woman doesn’t know shit about pharmacies. But she spreads a message that I have to deal with every day at work. Pharmacies, as a whole, are not your enemy. Drug manufacturers and insurance companies will cause most of your headaches. Corporations that overwork and underpay both the pharmacists and techs are also the problem too. (Look, I’m not saying there aren’t shit pharmacists and you can’t have a bad experience. I’ve met awful pharmacists and techs. But most people I’ve met truly care about their work and their patients).

[powerfultipsforyourhealth]

Dietary supplements for weight loss

Melt your body fat. And lose weight in a natural way. These may be catchy slogans, but are they really yielding results?

It can be difficult to counter the temptation to promise to lose weight quickly. Won't weight loss supplements lose anything but your money? Are these products safe?

What are supplements?

Dietary supplements are sold as health aids. It is an oral product. Its common components include vitamins, minerals, fiber, caffeine, herbs and other plants.

Some of the most well-known supplements claim to be able to improve nutrition, increase energy level, build muscle, or burn fat.

Supplements are not seen as medications. They are not produced to treat or cure diseases.

How to organize dietary supplements?

Companies that manufacture dietary supplements are responsible for the safety of their products. Such companies must ensure that their products are free of contaminants and labeled with accurate information.

Dietary supplements do not need to be approved by the U.S. Food and Drug Administration. But if the supplement is found to be unsafe, the U.S. Food and Drug Administration may issue warnings or request that it be withdrawn from the market.

The FDA may take action against companies that publish false or unsubstantiated claims to sell their dietary supplements.

Interpreting Weight Loss Claims

Perhaps it surprises you to learn that supplement makers rarely conduct clinical trials on them. This is part of the reason why there is little scientific evidence proving the effectiveness of supplements in weight loss.

For example, raspberry ketone supplement is marketed as a clinically approved weight-loss product. This claim is supported by one clinical trial.

The trial involved 70 obese adults. And all of them in this experiment underwent a strict diet and training regime. Participants were then randomly divided into two groups, one receiving a placebo and the other receiving a supplement containing raspberry ketone, caffeine, bitter orange extract, ginger and garlic root extract.

The 45 participants in the experiment underweight:

The average weight loss in the supplement group was 4.2 pounds (1.9 kilograms).

The average weight loss in the placebo group was 0.9 pounds (0.4 kilograms).

While these results are interesting, the small size of the trial and its duration of only eight weeks means that the results cannot be reliably generalized in practice. Most importantly, a short trial like this may overlook side effects that only appear after long-term use.

Furthermore, the experiment used a dietary supplement containing many active ingredients. That is why it is impossible to determine which of these components was responsible for weight loss.

Ideally, these preliminary results are tested in much longer trials involving hundreds of participants closely monitored for side effects. The results of such trials would allow for an informed decision as to the safety and efficacy of that product.

Until trial data are available and ready, claims about supplementation and weight loss should be treated with caution.

Understand safety concerns

Just because a product is natural doesn't mean it's necessarily safe. Some supplements are associated with serious problems such as kidney damage, although these accidents are rare.

Supplements may have powerful effects. Ephedra (Ma Huang) was previously used for weight loss. But the U.S. Food and Drug Administration has now blocked it because it is associated with some negative effects such as mood changes, high blood pressure, irregular heartbeat, stroke, tremor attacks and heart attacks.

Some weight-loss supplements have been shown to contain hidden ingredients, such as prescription drug ingredients, that may have harmful effects.

Search before you buy

If you're considering supplements that help you lose weight, it's important to do your part. Check credible websites, such as those operated by the U.S. Bureau of Dietary Supplements and the National Center for Complementary Medicine and Integrative Health.

Also, be sure to talk to your doctor before taking any dietary supplement. This is especially important if you're having health problems, taking prescription medications, or if you're pregnant or breastfeeding.