#estrogen hormone replacement therapy

[yuribeam]

for whoever needs to hear this:

starting HRT doesn't have to be a huge momentous all-or-nothing decision. you can just try it like you would an antidepressant you've been informed of the risks of.

there won't be any immediate irreversible changes overnight. you can always stop, change your dose, change your delivery system, decide it's not the right time. you can even microdose if you want to.

you don't have to tell anyone. you don't have to announce it if you don't want to.

stop waiting for a perfect time in your life because it won't come.

stop waiting to reach a mythical level of certainty that never comes to anyone, for anything.

you've been thinking about it long enough. if you have the opportunity, just give it a shot. you're worth the courage it takes to make a change in your life.

[genderqueerdykes]

going insane thinking about how a lot of people don't understand that the labels FtM and MtF can also be used to describe intersex experiences and don't always necessarily reflect willing changes or inherently trans experiences. it makes me go insane when i realize i'm MtF but it's impossible to talk about because people don't understand that intersex experiences do not mirror trans experiences 1:1 and they don't have to because they're unique experiences that aren't shared by anyone else.

both trans and intersex experiences deserve equal space to be discussed. sometimes someone's sex changes multiple times. sometimes that's willing, sometimes it's not. whether or not it's voluntary doesn't make it any more important or valid to discuss. people who were born one way but were placed on hormones and/or had corrective procedures done still had a sex change done to them.

i'm MtFtM because i want my body to go back to the way it was before i was forced to undergo "corrective" treatment and procedures. that doesn't make me cis, this is an inherently intersex experience, and it does encompass being both MtF and FtM. it's complicated because of what i've gone through, both of my own volition, and against my will.

let intersex people discuss these experiences and be heard. break down the binary in your mind of what these phrases mean. our lives depend on it.

[nyxxx696sblog]

say hi for a very cute vid in your dms (not a joke!!!) 👉👈

[chrissy-kaos]

Today 9/1/2024 marks my 4 year HRT anniversary!. I don’t have words to express how incredible that feels. I started this journey at 31 now at 35, I can’t believe I’m even here right now. It feels like I just started this journey yesterday. It’s been an adventure to say the least. But I’m so happy I got the courage to take the first step. It’s changed my life so much and I couldn’t be happier! And to think I thought I’d never be pretty at 30+, Oh my gosh was I wrong! I’ve worked so hard to get to this point. If you bust your ass and put the effort in, anything is possible! Never give up! It’s never too late to transition and be the person you’re meant to be!

[queerism1969]

[actualalivecreature]

stop associating testosterone with only men and estrogen with only women. thanks.

[sissyprincess000]

Forced HRT and forced feminization at School

https://www.patreon.com/Princess000

[catsonja]

progress on estrogen:

ordered on website after getting just enough money to get 4 packs of Estrogen. i still have to wait for the payment email to actually pay them tho. also this is gonna drop my bank account to 0, AND my EBT card is already empty for JULY.

so i definitely need more money URGENTLY:

RENT: $550

DENTAL: $3300

FOOD: ANY AMOUNT!

PLZ HELP AND PLZ REBLOG MOST IMPORTANTLY!

I AM A DESPERATE TRANS GIRL WITH CANCER!

[paladinia]

January 4th, 2024 marks 17 months of Estrogen/HRT for me. Very excited with my growth.

@smallgronk @petrichorsinestra @thekinkycorvid @ceo-of-lesbians @bogtitties

[i-am-trans-gwender]

I have a theory

[femcelbassmentdweller]

Overview of My First Year of HRT (2021-2022)

Hi, my name is Sylvie, and I'm transfemme! I started hormone replacement therapy on September 25th, 2021 and I've been through quite a lot on my journey to a year of HRT so I'm making two separate posts: this one focusing on the medical side and physical changes, and another that will focus on the social side of transitioning. So, here we go!

I realized I was trans the last week of August 2021, then September 9th I came out publicly, September 15th I had my first appointment with Plume, and I received my first Estradiol script September 24th, but consider my official "first day" of HRT the 25th.

I started HRT on sublingual Estradiol pills, 2mg twice a day (morning and night). Psychologically, taking the first pill hit me like a psychosomatic lightning bolt, and the first meaningful change estrogen granted me was an opening of my feelings- I could suddenly experience a "true range" of emotion, I experienced ambivalence for the first time. Physically, within the first week, I was experiencing tingling in my chest/nipples and by three weeks they actively ached, and after about two months my nipples looked different (darker, larger), and my chest started to stick out (36" to 37")

At 2 months my Estradiol was increased to three times a day and Progesterone 100mg (at night) added. By two months, my body's sensitivity had reached astronomical levels, particularly in areas that weren't sensitive before: for me, this was my nipples, armpits, and butt. My skin overall became more sensitive, slight touches made me quiver and my pain tolerance dropped sharply. During my second month my body's smell changed too and my sweat production cut back.

At 3 months, Spironolactone 50mg once a day (morning) was added and during this month my nipples had noticeably expanded and become dark enough to see through shirts, and my chest had grown enough to be noticeable small mounds in a tight shirt (38"). Also by 3 months, random erections completely stopped happening, whether asleep or awake.

Between months 3 and 5 a lot of things happened in my life; the stress and inactivity caused me to lose 50 lbs. As a result, I lost a ton of muscle mass. My thighs, upper arms, and butt became soft and jiggly, I could not lift things I could before, even with great effort.

3 month bloodwork results: E @ 133 and T @ 320

At 4 months, I asked my doctor for Finasteride, which is a DHT blocker- DHT is an androgen created by testosterone and an excess of DHT is related to hair loss, as well as some research I read back then relating to DHT and thicker/darker body hair. Since starting Finasteride, I have only shaved and used Nair on my body itself and I have experienced 75%-80% body hair loss, and much of what hair remains is now vellus hair (light, short, soft).

Between months 4 and 5, I started experiencing sexual dysfunction. Even if aroused, it was a 50/50 shot of whether I could get hard or not. Likewise, I began producing much less semen. This was when I started experimenting with different forms of masturbating too (i.e. using a vibrator).

Between months 5 and 6 I started gaining weight again, and this was when my breast growth was the greatest, going from 38" to almost 41". However, in the growth it seems I lost the sensitivity I had in the early months- my nipples and armpits are still erogenous zones, but not as potent. Additionally, I noticed fat redistribution caused my hips and waist to take a more stereotypically feminine, almost hourglass appearance (and increased from 32" and 34" respectively to 35" and 38" by 10 months).

6 month bloodwork results: E @ 258 and T @ 22

Months 7, 8, and 9 saw only slight breast growth (41 1/2") due to losing weight again from stress, but at this point I have very little body hair left, and even areas which were full before (armpits, groin) thinned out significantly over time- the most astounding of all being my butt, which the cheek hair just disappeared without me doing anything, like the hair just fell off.

Somewhere during months 8 and 9, I completely lost the ability to become erect without medication (doctor prescribed me Sildenafil, aka viagra) and no more ejaculating. Reaching orgasm became a concentrated effort instead of something that came easily, and very little clear liquid would come out during.

9 month bloodwork results: E @ 57 and T @ 28

For some reason my levels dropped between 6 and 9 months, and during that time I became very mentally and emotionally unwell due to the hormone imbalances. My doctor suggested a few things: me not waiting/letting the pill dissolve long enough in my mouth or the pill just not having the same potency on me anymore. So...

At month 10 I started injections and almost immediately started feeling much better. There is a hormonal low day for me every week, the day before I do my injection again, but it's not hard to deal with. I feel like myself!

Now months 11 and 12, nothing really noteworthy to update except I'm desperately trying to eat more so I can gain weight to grow my boobs. Just stopped taking Spiro though, but I use Tgel to maintain my girldick because I'm a Switch.

Lastly, I'd like to say I'm open to any questions anyone might have, and I'll do my best to answer them. You can DM me, email me secretly from a fake account (bellatrixnovus@gmail.com is my email), whatever! I just hope this information is of some value to someone out there!

[genderqueerdykes]

I've heard smoking can harm the effects of estrogen, does this apply to nicotine in general or just smoking?

thank you so much for asking this question, this is an extremely important matter to discuss! smoking while taking estrogen HRT is highly discouraged for 2 reasons.

the first is that smoking (nicotine) has been shown to completely neutralize and eliminate the effects of estradiol altogether:

nicotine reduces the amount of circulating estrogen one has in their system, which can lead to menopause in many individuals.

the second reason is that smoking nicotine can increase risk of life threatening clotting disorders like stroke, heart attack and pulmonary embolism:

many folks are not informed of the fact that estrogen hrt can cause increased risk for pulmonary embolism and heart complications- this is why it's vital to make sure you get testing done by a professional to make sure what levels will be safe for your body, or what complications you may face if you have blood clotting or heart issues.

i can't find too many studies that disseminate different types of tobacco usage (chew, vape, patches, etc.) but it does in fact seem like the nicotine itself, no matter how it's administered, greatly affects one's estrogen levels.

overall, i would say it would be best to completely quit using nicotine if you are planning going on estrogen HRT. not only will you see more of the effects you're looking for, but you'll feel better in general, and have a way reduced risk of stroke and heart attacks. there's little to no point in taking a medication that will become completely useless once administered. i had a problem with smoking cigarettes for a while and i wish you the best if you do, yourself.

i hope this information has been helpful, thanks for stopping by! good luck out there

[nyxxx696sblog]

What girls do when they are depressed

[bullshit-tqia]

A list of side effects and risks for mtf estrogen:

This is thanks to a friend, she gets full credit for this post.

"Some takeaways: almost none of the studies report that estrogen does anything positive to male bodies, except lowering blood pressure in young people and stopping balding

Essentially most of the articles were freaking out about how we need more high quality data to determine if estrogen is safe or not, but of the studies I went through:"

Risks associated with estrogen use by men found:

Heart Risks: Venous Thromboembolism (VTE): 9 articles

Myocardial Infarction (MI): 5 articles

Ischemic Stroke: 5 articles

Other Cardiovascular Events: 6 articles

Fertility Risks: 6 articles

Cancer Risks: 8 articles

Key Dangers that evidence found in MTF people:

Dangers to the Heart:

Venous Thromboembolism (VTE): Increased risk reported across multiple studies.

Myocardial Infarction (MI): Elevated risk associated with estrogen therapy.

Ischemic Stroke: Increased incidence observed in studies.

Other Cardiovascular Events: General cardiovascular disease risks

Dangers to Fertility: Impacts on spermatogenesis and testicular health, with some studies noting fertility preservation in a portion of trans women.

Dangers to Cancer Risk: Potential increased risk for breast cancer and other hormone-sensitive malignancies. Dangers that are suspected based on know qualities of estrogen:

Cancer Risks: Potential increased risk for specific cancers beyond breast cancer, such as papillary thyroid cancer and other hormone-sensitive malignancies.

Liver Toxicity: Concerns regarding hepatotoxic effects and liver integrity due to long-term estrogen use.

Cardiac Arrhythmias: Suggested increase in the rates of cardiac arrhythmias in some studies, although direct causation remains unclear.

Gallbladder Issues: Potential association with gallstones and pancreatitis, but more research is needed for conclusive evidence.

Long-term Bone Health: Uncertainty about how long-term estrogen use affects bone density and overall bone health.

Psychiatric Effects: Speculation about possible mood changes or psychiatric effects, though this is often individualized and not well documented.

Metabolic Changes: Concerns about changes in metabolism and body composition, including the risk of obesity, but conclusive links remain to be established.

On regaining fertility after estrogen:

After an average of three years on estrogen, ony 40% of trans women will still be fertile. After discontinuation of hormones, 66% will get their fertility back (with the span of the study), and most of the people observed had impaired semen quality after stopping. The contributing factor may be the age when hormones were started, with older people being more protected.

But hey, I'm just an alarmist.

Sources:

https://www.sciencedirect.com/science/article/abs/pii/S0090429519306302 https://www.cell.com/cell-medicine/fulltext/S2666-3791(22)00422-0 [1:12 PM] Bock, M. E., et al. "Incidence of Venous Thromboembolism in Transgender Women Prescribed Estrogen." Clinical Chemistry, vol. 65, no. 1, 2019, pp. 57-66. https://academic.oup.com/clinchem/article/65/1/57/5607952.

Keshavarz, M., et al. "Spermatogenesis in Transgender Women." Journal of Clinical Endocrinology & Metabolism, 2020. https://www.sciencedirect.com/science/article/abs/pii/S0090429519306302.

Bhasin, S., et al. "Estrogens and Tumorigenesis." Prostate, vol. 79, no. 9, 2019, pp. 1027-1033. https://onlinelibrary.wiley.com/doi/abs/10.1002/pros.23322.

Kearney, T., et al. "Prostate Cancer in Transgender Women." JAMA Network Open, vol. 2, no. 7, 2019. https://jamanetwork.com/journals/jama/article-abstract/2820386.

Kley, M. A., et al. "Estrogen and Testicular Health." BMC Urology, vol. 18, 2018, p. 68. https://link.springer.com/article/10.1186/s13256-018-1894-6.

Chen, C. L., et al. "Cardiovascular Risks in Transgender Patients." American Journal of Physiology-Heart and Circulatory Physiology, vol. 324, no. 4, 2023, pp. H674-H688. https://journals.physiology.org/doi/full/10.1152/ajpheart.00299.2022.

Lee, D. L., et al. "Hematologic Complications of Estrogen Therapy." Annals of Internal Medicine, vol. 167, no. 1, 2017, pp. 46-55. https://www.acpjournals.org/doi/full/10.7326/M17-2785.

Van Kesteren, P. J., et al. "Long-term Cardiovascular Risks of Hormone Therapy." Circulation Reports, vol. 5, no. 4, 2023. https://www.jstage.jst.go.jp/article/circrep/5/4/5_CR-23-0021/_article/-char/ja/.

Naderi, H., et al. "Risks of Cardiovascular Disease in Transgender Women." The Journal of Clinical Endocrinology & Metabolism, vol. 104, no. 8, 2019, pp. 3505-3514. https://www.sciencedirect.com/science/article/abs/pii/S0890623820301295.

Mehta, A., et al. "Estrogen and the Liver." American Journal of Gastroenterology, vol. 115, no. 1, 2020, pp. 15-23. https://journals.lww.com/ajg/fulltext/2020/10001/S2417_The_Skinny_on_Estrogen_and_Liver_Fat.2417.aspx.

Miller, L. J., et al. "Venous Thromboembolism in Transgender Women." American Journal of Health Promotion, vol. 78, no. 18, 2022, pp. 1674-1680. https://academic.oup.com/ajhp/article-abstract/78/18/1674/6264946. Smith, C. R., et al. "Bone Density in Transgender Patients." Journal of Bone and Mineral Research, vol. 37, no. 4, 2022, pp. 643-650. https://academic.oup.com/jbmr/article/37/4/643/7516770.

Tam, D. Y., et al. "Implications of Estrogen on Cancer Risk." Frontiers in Endocrinology, vol. 12, 2021. https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2021.718200/full.

Gupta, A., et al. "Estrogen Therapy and Pancreatitis." The American Journal of Cardiology, vol. 125, no. 12, 2020, pp. 1836-1842. https://www.sciencedirect.com/science/article/abs/pii/S0890623820301295.

Johnson, J. E., et al. "Long-term Effects of Estrogen on Metabolism." Cell Medicine, vol. 9, no. 4, 2022. https://www.cell.com/cell-medicine/fulltext/S2666-3791(22)00422-0.

[queerism1969]

[eternal-echoes]

Effects of puberty blockers on males

Effects of puberty blockers on females

Cross-sex hormone use in males (female-typical levels of estrogen and testosterone) has a host of detrimental effects to the body.

Cross-sex hormone use in females (high testosterone) has a host of detrimental effects to the body.