#bioavailable

[omg-erika]

Forever young – thanks to NMN?

by Dr.Harald Wiesendanger– Klartext What the mainstream media is hiding You can spend a fortune on anti-aging products – with questionable benefits and uncertain side effects. NMN seems to be a notable exception. The more deeply this substance is researched, the more clearly its spectacular potential to keep us healthy and vital even as we get older becomes clear. “I want to grow old with…

[benihana-circumcision]

HELP HEEELP HEEEELPPP

[tj-crochets]

Okay y'all, my doctor wants me to take iron supplements and inexplicably recommended a vegan one I can't take* despite the whole heme/non-heme iron thing and the whole "I'm not vegan" thing. Do you have any iron supplements you recommend? *it has raw garlic and onion in it. I can have both garlic and onion, but only cooked

[sacrificialcrisis]

next month I'm going ham with leafy greens and if that doesn't work I'm going to have to try eating red meat again 🥲

[vaciena]

You wanna know something terrible?

My new med, that I have to take 4 or 8 of a day for forever, costs $1120

It’s literally $40-80 a day for one med

[snapcracklepop-myjoints]

If u snort adderall in one nostril and Xanax in the other ur brain takes a screenshot

[jppres]

Conceptos y aplicaciones de los parámetros farmacocinéticos: Una guía para el salón de clases. | [Concepts and applications of pharmacokinetic parameters: A guide for the classroom]

Article published in J. Pharm. Pharmacogn. Res., vol. 11, no. 1, pp. 160-178, January-February 2023. DOI: https://doi.org/10.56499/jppres22.1472_11.1.160 Expert Opinion Jorge Duconge-Soler1*, Víctor Mangas Sanjuan2, Gledys Reynaldo Fernández3 1Departamento de Ciencias Farmacéuticas, Escuela de Farmacia, Universidad de Puerto Rico, PO Box 365067, 00936-5067, San Juan, Puerto…

[koranika]

I hate to be the one to say this but where do y’all think a lot of the nutrients in soil comes from?

i think it's fucked up that there are plants that decided they wanted to eat meat

[ingredientsonline]

Why Better Bioavailability Matters: Maximizing Absorption Efficiency

In health and nutrition, one crucial element for achieving the best results is bioavailability. This concept describes how well the body absorbs and uses nutrients from the foods and supplements we take. If absorption is inadequate, even the most nutrient-dense products may not provide their complete advantages. This article delves into the importance of enhanced bioavailability and how optimizing absorption can reveal the full benefits of essential nutrients for better health and wellness. Click here to learn more.

[maxicuma]

FAQs on Turmeric Curcumin Benefits, Bioavailability

Have questions about Maxicuma? Our FAQs page covers topics like product usage, benefits, and technology. Get informed quickly.

[lesbakerstuff]

tldr: tampons are made of cotton, which can take up lead from soil. the soil can get lead from lead in the atmosphere, wastewater containing lead, or pesticides/fertilizers with lead!

im curious if there's ever been a study looking at blood lead levels in menstruating people who use tampons vs who don't - controlled for other lead exposure methods ofc

my period is back again and id like to take this moment to remind everyone with a uterus to avoid using tampons at all costs, if you can. a recent study was conducted with 14 different popular brands of tampons, revealing that every single one of them contained toxic metals such as lead, arsenic, and more.

[curiousquill1]

Science Behind Spheronization: Why Shape Matters in Pharmaceutical Production

The pharmaceutical manufacturing world is pretty complex. The size of the particles is one prime consideration that can make a world of difference in achieving quality and effective medicines. At the core of it lies spheronization—the process of converting raw material into uniform spherical particles in order to improve the production efficiency and performance of the final drug product.

Awareness: Spheronization and Its Implication in the Pharmaceutical Industry

Spheronization refers to an advanced pelletizing technique that results in creating nearly round particles from a powder, granules, or other forms of solid. One can even control the process of production by changing the process variable inside a spheronizer. The size distribution is narrow and specific to formulation requirements for spherical particles resulting from the spheronizer.

So why does this round shape make so much difference in pharmaceutical? This is basically because the physical properties are unique which the spherical particle possesses. Compared with irregular particles, the spherical particle has the flowability feature. For this reason, it could easily feed to the equipment smoothly and with consistency—the tableting equipment, and the encapsulation equipment for that matter. It can be compressed to a considerable pressure, hence making sturdy, excellent tablets, capsules, and so forth.

Ultimately, the spherical shape unlocks major benefits through the entire pipeline of pharmaceutical production, from streamlining manufacturing processes to improving quality and performance of the final drug product. That is why spheronization has become an indispensable tool in the modern pharmaceutical industry.

Consideration: Technical Advantages of Spherical Particles

The very simple yet highly creative process on which lies the heart of spheronization involves taking pharmaceutical powders or granules and introducing them to the particular equipment like the spheronizer. Once this is done, a controlled rotation, coupled with friction, ensues, and the smooth agitation makes the particles turn into almost perfect spheres because of a gradual process of forming rounded shapes.

There are many technical advantages of the spherical shape per se. First, an ideally uniform particle size as well as a relatively smooth surface renders spheres better flow and handling properties which are really of great importance for assured dosing that is reproducible in the process of tabletting, encapsulation, or other types of filling operations. This sort of fluidity allows fewer stops of machinery, decreased scrap, and therefore generally increased output.

However, the advantages of spheronization go far beyond making a production process easier. The round shape also plays a very important role in performance and stability of the drug product in the end. Spherical particles are usually characterized by more favorable dissolution profiles and have drug release kinetics that are predictable and reproducible. Further, the size and distribution of spheronized particle sizes may also stabilize the physical properties of formulation, reducing the possibility of segregation or caking over time during storage and shipping.

Conclusion: Practical Applications of Spheronization Technology

The versatility of spheronization technology makes it a valuable tool for a range of pharmaceutical applications. The ability to produce high-quality, spherical particles is one of the key enablers for manufacturers looking to provide effective and reliable drug products for patients—from immediate-release tablets to controlled-release beads.

Another excellent use of spheronization is in multiparticulate drug delivery systems. Uniform spherical pellets or minitablets formed with the help of a dedicated spheronizer allow the formulator to design complex release profiles suitable for the particular physiological requirements of the patient. This precision, as one might expect, is directly translatable into improved clinical performance and patient experience.

There are many other applications where it extends far beyond the drug. Thus, manufacturing fertilizers produce spherical granules, which can improve spreading while reducing dust and will be efficient to apply without creating hazards on workers' safety. For the sphere in ceramics or abrasives, it would increase polishing performance and lessen the amount of wear of the machines.

By passage of time, its importance will continue to augment amongst the pharmaceutical industries about this spheronization technology. Through the application of principles and scientific knowledge for developing uniform, spherical particles to manufacture through a specialized machine that reduces the production line's steps and increases product quality in a final healthcare delivery line that benefits patient well-being.

In situ, raw materials are to be shaped into uniform performing particles—a vital part of the contemporary pharmaceutical arsenal with more complex drug formulations bringing a demand for improvement and spheronization. Total control by pharmaceutical companies in the science behind such a process will unlock new dimensions that can further efficiency, quality, and innovation—all within improved safety and efficacy for patients in medical treatments.

[pureforlife-llc]

Maximizing CBD Absorption with Pure for Life™ 🌿💧

Want to ensure you’re getting the full benefits of your CBD? Understanding bioavailability is key! We dive into the science of CBD absorption and explore cutting-edge methods like lipid-based formulations and solid-state technologies to improve effectiveness. Learn how Pure for Life™ is revolutionizing CBD absorption. 🌟

[openintegrative]

ALA vs. DHA & EPA Omega-3: Why Source Matters

ALA (Alpha-Linolenic Acid) is found in flaxseeds, chia seeds, and walnuts, but converts poorly to DHA and EPA.

DHA and EPA are critical long-chain omega-3s found in animal sources like fatty fish and are essential for brain and heart health.

The body converts ALA to DHA and EPA inefficiently, with conversion rates often less than 10%.

Direct consumption of DHA and EPA from animal sources is more effective for meeting nutritional needs.

Vegans may need to rely on algal oil to obtain sufficient DHA and EPA.

Introduction

Omega-3 fatty acids are vital for numerous bodily functions, particularly brain and heart health.

There are different types of omega-3s, with ALA being a short-chain omega-3 found in plant foods, and DHA and EPA being long-chain omega-3s primarily sourced from animal products.

Understanding the differences between these fatty acids is important, especially for those following specific dietary preferences like veganism.

Overview of ALA (Alpha-Linolenic Acid)

ALA is a plant-based omega-3 fatty acid commonly found in foods like flaxseeds, chia seeds, and walnuts.

While ALA plays a role in maintaining overall health, it must be converted into DHA and EPA—forms of omega-3 that the body can directly utilize.

Unfortunately, the conversion rate of ALA to DHA and EPA is often less than 10%, making it a less efficient source of these critical nutrients.

DHA (Docosahexaenoic Acid) and EPA (Eicosapentaenoic Acid)

DHA and EPA are long-chain omega-3 fatty acids predominantly found in animal sources, such as fatty fish, cod liver oil, and organ meats.

These omega-3s are essential for brain function, heart health, and reducing inflammation.

Unlike ALA, DHA and EPA are directly available for the body to use, making them more effective at supporting these critical bodily functions.

Bioavailability and Nutritional Impact

The bioavailability of omega-3s refers to how well the body can absorb and use these nutrients.

ALA has lower bioavailability due to the inefficient conversion process, which means the body struggles to get enough DHA and EPA from ALA alone.

In contrast, DHA and EPA from animal sources are highly bioavailable, providing immediate nutritional benefits without the need for conversion.

Health Implications

Relying solely on ALA for omega-3 intake can lead to deficiencies in DHA and EPA, which are vital for cognitive health, cardiovascular function, and inflammation control.

Adequate intake of DHA and EPA has been linked to reduced risks of heart disease, improved brain health, and better inflammatory responses.

Vegans who do not consume DHA and EPA from animal sources may face health challenges if they don’t supplement properly.

Vegan Alternatives and Considerations

Vegans looking to meet their omega-3 needs can turn to algal oil, a plant-based source of DHA and EPA.

While algal oil can provide these essential fatty acids, it may not be as easily accessible or affordable as traditional animal sources.

Despite this, it remains the best option for vegans who want to ensure they receive adequate amounts of DHA and EPA.

Conclusion

ALA, DHA, and EPA are all important omega-3 fatty acids, but they differ significantly in their sources, bioavailability, and effectiveness. For those following a vegan diet, understanding the limitations of ALA and the necessity of supplementing with DHA and EPA is crucial for maintaining optimal health. Animal-based omega-3s remain the most efficient and effective source, but with careful planning and supplementation, vegans can also meet their omega-3 needs.

FAQ

What are the best vegan sources of ALA?

Flaxseeds, chia seeds, and walnuts are among the richest sources of ALA.

Can ALA fully replace DHA and EPA in a vegan diet?

No, due to low conversion rates, ALA cannot fully replace DHA and EPA.

Are there vegan sources of DHA and EPA?

Yes, algal oil is a vegan source of DHA and EPA.

What happens if I don’t get enough DHA and EPA?

Insufficient intake can affect brain function, heart health, and inflammation levels.

Is it necessary to supplement with DHA and EPA if I’m vegan?

Yes, supplementation with algal oil is recommended to ensure adequate intake.

Research

Attar-Bashi, N.M., Weisinger, R.S., Begg, D.P., Li, D. and Sinclair, A.J., 2007. Failure of conjugated linoleic acid supplementation to enhance biosynthesis of docosahexaenoic acid from α-linolenic acid in healthy human volunteers. Prostaglandins, Leukotrienes and Essential Fatty Acids, 76(3), pp.121–130.

Baker, E.J., Miles, E.A., Burdge, G.C., Yaqoob, P. and Calder, P.C., 2016. Metabolism and functional effects of plant-derived omega-3 fatty acids in humans. Progress in Lipid Research, 64, pp.30–56.

Brenna, J.T., Salem, N., Sinclair, A.J. and Cunnane, S.C., 2009. α-Linolenic acid supplementation and conversion to n-3 long-chain polyunsaturated fatty acids in humans. Prostaglandins, Leukotrienes and Essential Fatty Acids, [online] 80(2–3), pp.85–91. https://doi.org/10.1016/j.plefa.2009.01.004.

Burdge, G.C., 2006. Metabolism of α-linolenic acid in humans. Prostaglandins, Leukotrienes and Essential Fatty Acids, 75(3), pp.161–168.

Burdge, G.C. and Calder, P.C., 2005. α‐Linolenic acid metabolism in adult humans: the effects of gender and age on conversion to longer‐chain polyunsaturated fatty acids. European Journal of Lipid Science and Technology, 107(6), pp.426–439.

Burdge, G.C. and Calder, P.C., 2006. Dietary α-linolenic acid and health-related outcomes: a metabolic perspective. Nutrition Research Reviews, 19(1), pp.26–52.

Burdge, G.C. and Wootton, S.A., 2002. Conversion of α-linolenic acid to eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in young women. British Journal of Nutrition, 88(4), pp.411–420.

Burdge, G.C., Jones, A.E. and Wootton, S.A., 2002. Eicosapentaenoic and docosapentaenoic acids are the principal products of α-linolenic acid metabolism in young men. British Journal of Nutrition, 88(4), pp.355–363.

Chen, H., Deng, G., Zhou, Q., Chu, X., Su, M., Wei, Y., Li, L. and Zhang, Z., 2020. Effects of eicosapentaenoic acid and docosahexaenoic acid versus α-linolenic acid supplementation on cardiometabolic risk factors: a meta-analysis of randomized controlled trials. Food & Function, 11(3), pp.1919–1932.

Egert, S., Kannenberg, F., Somoza, V., Erbersdobler, H.F. and Wahrburg, U., 2009. Dietary α-Linolenic Acid, EPA, and DHA have differential effects on LDL fatty acid composition but similar effects on serum lipid profiles in normolipidemic humans. The Journal of Nutrition, 139(5), pp.861–868.

Fleming, J.A. and Kris-Etherton, P.M., 2014. The evidence for α-linolenic acid and cardiovascular disease benefits: comparisons with eicosapentaenoic acid and docosahexaenoic acid. Advances in Nutrition, 5(6), pp.863S-876S.

Gerster, H., 1998. Can adults adequately convert α-linolenic acid (18: 3n-3) to eicosapentaenoic acid (20: 5n-3) and docosahexaenoic acid (22: 6n-3)?. International Journal for Vitamin and Nutrition Research, 68(3), pp.159-173.

Gibson, R., Neumann, M., Lien, E., Boyd, K., & Tu, W., 2013. Docosahexaenoic acid synthesis from alpha-linolenic acid is inhibited by diets high in polyunsaturated fatty acids. Prostaglandins, Leukotrienes and Essential Fatty Acids, 88(1), pp.139-146.

Gibson, R.A., Muhlhausler, B. and Makrides, M., Conversion of linoleic acid and alpha-linolenic acid to long-chain polyunsaturated fatty acids (LCPUFAs), with a focus on pregnancy, lactation and the first 2 years of life. Maternal & Child Nutrition, 7, pp.17-26.

Goyens, P.L., Spilker, M.E., Zock, P.L., Katan, M.B. and Mensink, R.P., 2006. Conversion of α-linolenic acid in humans is influenced by the absolute amounts of α-linolenic acid and linoleic acid in the diet and not by their ratio. The American Journal of Clinical Nutrition, [online] 84(1), pp.44–53. https://doi.org/10.1093/ajcn/84.1.44.

Greupner, T., Kutzner, L., Nolte, F., Strangmann, A., Kohrs, H., Hahn, A., Schebb, N.H. and Schuchardt, J.P., 2018. Effects of a 12-week high-α-linolenic acid intervention on EPA and DHA concentrations in red blood cells and plasma oxylipin pattern in subjects with a low EPA and DHA status. Food & Function, [online] 9(3), pp.1587–1600. https://doi.org/10.1039/c7fo01809f.

Liou, Y.A., King, D.J., Zibrik, D. and Innis, S.M., 2007. Decreasing linoleic acid with constant α-linolenic acid in dietary fats increases (n-3) eicosapentaenoic acid in plasma phospholipids in healthy men. The Journal of Nutrition, 137(4), pp.945–952.

Mantzioris, E., James, M., Gibson, R. and Cleland, L., 1995. Differences exist in the relationships between dietary linoleic and alpha-linolenic acids and their respective long-chain metabolites. The American Journal of Clinical Nutrition, 61(2), pp.320–324.

Rapoport, S.I., Rao, J.S. and Igarashi, M., 2007. Brain metabolism of nutritionally essential polyunsaturated fatty acids depends on both the diet and the liver. Prostaglandins, Leukotrienes and Essential Fatty Acids, [online] 77(5–6), pp.251–261. https://doi.org/10.1016/j.plefa.2007.10.023.

Salem, N. and Eggersdorfer, M., 2015. Is the world supply of omega-3 fatty acids adequate for optimal human nutrition?. Current Opinion in Clinical Nutrition and Metabolic Care, 18(2), pp.147–154.

Takic, M., Pokimica, B., Petrovic-Oggiano, G. and Popovic, T., 2022. Effects of dietary α-linolenic acid treatment and the efficiency of its conversion to eicosapentaenoic and docosahexaenoic acids in obesity and related diseases. Molecules, 27(14), p.4471.

Wendland, E., 2006. Effect of α-linolenic acid on cardiovascular risk markers: a systematic review. *Heart*, 92(2), pp.166–169.

[222beer]

I went to a Maker's Swap yesterday! It was amazing. I exchanged tarot readings for fresh lemon rosemary sourdough bread, mustard pickles, a deer leg!, fresh curry, zucchini, and a painting. I was so blissful!