#Longevity research

[thinkmeatmarinades]

Off all the arguments against longevity research “life requires death to have meaning” is one of the hardest to coherently argue against beyond simply saying “wtf no it doesn’t”. This is going to me trying to do that.

When we get down to it, the need for a meaningful life is a social one. It’s the drive to touch others lives, to create a better world. We measure meaning in how our acts influence others, and in the absence so other people meaning is fundamentally impossible. Death makes further acting impossible – it merely allows a life to be ‘tallied up’ with a specific end point, and we don’t have to worry about whether one has done ‘enough’, or fear that future acts will undo any good we’ve wrought.

It’s like saying a piece of art isn’t finished without a signature. Perhaps accurate, the signature doesn’t actually influence the artwork in any way, it merely signifies that the work can now be evaluated. Moreover, this implies that a Life is something that can in some way be ‘completed’ instead of merely cut short.

It’s also worth noting that longevity and/or biological immortality in no way innures you against Loss. Your friends and family will move away and you’ll never see them again, the band you like will break up, and in general the world will change and in so doing take away the things you love, but what is guaranteed is the chance to find new things and people to love.

It’s much simpler to appreciate the transient beauty of Roses when you’ll get to see them again someday.

[omg-erika]

Forever young – thanks to NMN?

by Dr.Harald Wiesendanger– Klartext What the mainstream media is hiding You can spend a fortune on anti-aging products – with questionable benefits and uncertain side effects. NMN seems to be a notable exception. The more deeply this substance is researched, the more clearly its spectacular potential to keep us healthy and vital even as we get older becomes clear. “I want to grow old with…

[unbfacts]

[hexjulia]

huh!

[devoursjohnlock]

So many people on that post about academic publishing saying "burn it down", like... yes, the current system is bad in several ways, but what do you propose to replace it? I guarantee bad actors will be racing to incorporate pseudoscience and AI into whatever that is.

[mossy-covered-bones]

Laptop shopping’s hard. Please just tell me how good your processor is with numbers so i can quantify whether youre worth the extra hundred dollars. How much space is enough. Where the FUCK did you write the graphics card information

[randompokemonfacts]

Could you do relicanth?? I feel like they’re quite under appreciated

Sure, I'd be more than happy to!

- Professor Dexter

Pokémon that was requested: Relicanth!

Did you know that Relicanth feeds on microscopic organisms with its toothless mouth? This ancient Pokémon's body is filled with fat, so it can withstand the water pressure of the deep sea. Relicanth is also covered in tough scales that are like craggy rocks!

Prior Post about Relicanth

[unopenablebox]

even otherwise very likeable people spend too long in the bay area and start telling you that going to rationalist social events is okay

[todayisafridaynight]

Bro last night was so much......... I'm still reeling...... What even.... They gave us so much. I wasn't ready. I wasn't ready. I didn't KNOW.

Hear me out... Poundmates Jo........ Not a party member but maybe helpful. Him looking soft has me so fucked up. Why is Akane alive. Why is she alive bro. Why does Jo know she alive. Why would he- FUCK dude I'm trying to work but all I can think about is 8

i hope we get poundmates jo and we have to do it pokemon style where we have to beat his ass and then catch him <- delusional

[timewormbloom]

Side effect of doing research that no ones tells you about: I now have beef with a hormone receptor. and maybe also bones as a whole.

[inventforgood]

My idea is that cDNA libraries of the mRNA from humans of different ages, eg 1 year, 5 years, 10 years, 15 years, 22 years, 30 years, 40 years, 55 years, 70 years and 85 years (but practically it would be necessary to just take the samples that became available!) could be constructed or acquired. They could also be acquired from specific “aging critical” tissues/organs eg endothelium, cardiac, pulmonary, kidney, brain etc. The cDNA libraries could be compared by constructing microarrays (that is my dated knowledge but today it could probably be done computationally).

What would that give us? By the differences in the transcriptome between the different age cohorts it would show the difference between aged tissues and young tissues.

Of course, how these differences arose is AS a result of the epigenetic processes, but the differences themselves ARE the results of the epigenetic processes and (in some way which I am not able to imagine right now) may lead to approaches to discover more about the epigenetic processes themselves, which is your interest. Please forgive me if I am telling you things that are already second nature to you, but there is more to my proposal which is in fact quite simple really although very broad in scope and ambitious in outcome.

The differences mentioned above would be either the absence of specific mRNA in older tissues that is present in younger tissues, or vice versa, or quantitative differences in levels of mRNA.

That then gives a series of mRNA targets to investigate, both upstream, in terms of regulation of transcription such as transcription factors and silencing, and downstream in terms of identifying and characterising the protein product of the mRNA, its structure, binding sites, effects etc. That as you said before is quite a considerable body of work and would require many teams of researchers.

As far as intervention to promote health is concerned, discovering the epigenetic processes which cause the changes would be one pathway to treatments; other pathways could be pharmaceutical, perhaps based on transcription factors, and gene-therapy based approaches.

I think that the approach I have outlined is slightly different to that of the Yamanaka factors, which reset some cells to pluripotent stem cells, as my approach is intended to make differentiated cells youthful but still basically differentiated, as in the functioning young

adult.

I have heard of a researcher called Jaoa de Magalhaes who was said to be doing something like what I suggest (and he has now moved to Birmingham University in Britain) but I do not see mention of it on his website, he talks about long lived species, another interesting approach. An academic in Cambridge told me that she had heard of something like this that I propose being done in Singapore, but did not know the name of the researcher. So, although this approach is not truly novel, I believe it is still new ground.

[askshivanulegacy]

But does it have a headphone jack?

(No.)

There are two configurations available: one with 6GB of RAM and 128GB of storage for $599 and another with 8GB of RAM and 256GB of storage for $679. The storage of both models can be expanded via microSD, and the phone features a modular design that can be easily disassembled using a standard Phillips #00 screwdriver to replace broken components. It also has an IP54 rating, meaning the device is protected against dust and water sprays.

The Murena Fairphone 4 will ship to US customers with 5G and dual SIM support, a removable 3905mAh battery, a 48-megapixel main camera, a 48-megapixel ultrawide, and a 25-megapixel selfie camera. The phones will be available to order exclusively from Murena’s webstore starting today. 

[wild-wow-facts]

Naked Mole Rats: Nature's Odd Resilience

Discover the secrets of the naked mole rat! These fascinating creatures can survive without oxygen for long periods. Uncover more about their unique abilities!

Check out my other videos here: Animal Kingdom Animal Facts Animal Education

[mehmetyildizmelbourne-blog]

What would you like to know about Klotho, FOXO3, SIRT1, APOE, & BRCA

These are known longevity genes covered in an important story by Dr Yildiz in my publication. Today Dr Mehmet Yildiz wrote an article titled Questions and Answers for Longevity Genes in an Important Story and submitted to my Health and Science publication on Medium.com. He is a regular contributor and he also mentors me for growing this publication now serving over 500 writers. In his own…

[dynamichealthinsights]

The Intricate Dance of Genes and Longevity: Decoding the Blueprint for a Longer, Healthier Life

The pursuit of longevity has been a constant thread woven through the tapestry of human history. From the mythical Fountain of Youth to the cutting-edge laboratories of today, our fascination with extending lifespan and enhancing the quality of our later years remains unwavering. In this age of scientific marvels, genetic research has emerged as a beacon of hope, illuminating the intricate…