#alleviation of depression like symptoms

[damneddunya]

Biohacking for my parents is clearly working. Mum's literally done 16.5km of walking/jogging with resistance training afterward over the past 2 days at 60 years old.

What's more amazing is that she was bed ridden 3 years ago... unable to tie her own hair.

God is good 👏

[tunaababee]

.

[dandelionjack]

session with the psychiatrist today and he finalised getting me a s*roquel prescription… upon a google i discovered that one of the most common side effects is supposedly weight gain so now i am actually considering the preferred alternative option of recovery which is k*lling m*self

[psychoticallytrans]

A commonly overlooked symptom of depression is anhedonia, the inability to feel joy or pleasure. The reason that it's easy to overlook is that it's easier to miss the absence of something that's not around all the time than it is to miss a symptom that causes active distress, such as feeling tired and miserable all the time.

Anhedonia is good at being a persistent undercurrent to your life. My aunt, who has major depressive disorder, related to me that she figured out that something was wrong when she looked at the daffodils she had planted blooming, and couldn't recognize the emotion that she felt when she looked at them. It had been long enough since she had felt happy that she lost the ability to recognize the emotion.

It's a particularly dangerous depressive symptom, because it robs you of the ability to feel those little spots of joy that keep a lot of people going, while not doing anything to impair your ability to function. If you don't know that this is a treatable symptom of depression, it's easy to assume that your ability to feel good is permanently broken, and decide to commit suicide because you don't want to live like that. It's not an irrational conclusion, but it is an uninformed one, and everyone deserves to have all the information when making a major decision.

This is what a lot of questionnaires are trying to look for when they ask about "loss of enjoyment". If you can't remember a loss of enjoyment because you can't remember enjoyment, then you probably have anhedonia. If you struggle to define how it is to feel "happy", "content", or "good", or how it feels when you feel those emotions, you probably have anhedonia. If you can't remember feeling any of those emotions for a week or more, you probably have anhedonia.

Symptoms commonly co-occurring with anhedonia are fatigue (often the cause), clear and thoughtful consideration of suicide, loss of desire to socialize or do activities that used to make you happy, and weight loss (due to lack of enjoyment of food).

This section is anecdotal. In what I have observed, anhedonia due to fatigue rarely responds well to depression treatment unless depression was causing the fatigue. If fatigue and anhedonia are co-occurring and are not both alleviated by depression treatment, consider other causes for the fatigue.

[peachesofteal]

Through Me (The Flood) - secret baby fic Simon Riley / female reader - warnings: postpartum depression, 18+ brief sexual content

"Okay, Ry ry, come on. Work with me. You're alright, baby, it's okay."

You're pacing back and forth across the living room in only a nursing bra and Simon's favorite pair of your shorts, the ones that barely cover the soft pleat where the tops of your thighs meet your cheeks. The coverage of your ass is just barely there, crescent moons creased in invitation for his tongue- willing him, tempting him to lick long lines from outside to inside until you’re spread wide over his face.

Now is not the time, however.

He watches you carefully, analyzing, cataloging, categorizing. Looking for a sign, a symptom, a warning that you might not be feeling as good as you let on. Tough little kitten. Stronger than you think.

The doctor told you to get better rest, eat more nutritionally dense foods, and hydrate. If the dizziness and fainting doesn’t improve, you’ll have to see a specialist.

He’s been breathing through his nose a lot, since you told him. Willing his heart rate to slow, urging himself to be calm.

Still-

His nightmares are no longer made up of his past, but his future. Sequences of you, unconscious on the floor, baby screaming in his crib. Simon nowhere to be found, hundreds of miles away with his finger on a trigger.

You slump in defeat. Orion screams at the top of his lungs, angry at what, you’re not sure. He's tried not to hover, opting to cook dinner instead, but when your voice cracks on your next plea for Orion to stop crying, he breaks away from the kitchen and settles behind you, firm hand rubbing circles into your hip. "Let's give you a break, mama."

You sniffle. "I don't know what's up with him tonight. He won't latch, but he has to be hungry. I don't know what to do." Simon slides a forearm under yours, supporting the baby’s weight, the other one palming your belly. Your head tips back against his chest, heat radiating from your body like a furnace, and he sways you side to side, careful and slow, rocking the two of you in a gentle rhythm. You're both overheated, and you've long stripped Ry down to a diaper, hoping it would alleviate some of his misery.

"Let me take over. You're exhausted." He kisses your neck, using the light shiver shuddering over your skin to his advantage. His touch gentles you, reins in the stubborn streak that keeps surfacing, and he carries no weight of regret when he twists you up with it a little bit. He’s been standing at the bottom of the well, waiting to catch you when you break. "Go get in the shower, and I'll try a bottle in a bit. See if I can't get him calmed down." He presses his lips to your shoulder.

"But... dinner..."

"It can wait. Go on." He lifts Orion, sitting him upright on his chest, and then gives you a gentle swat on your ass.

It doesn't take much convincing after that.

He tries to get Orion to take the plastic nipple of the bottle, tries rubbing on his cheek to trigger the rooting reflex, like you've taught him, to no avail. "Alright, little man. Let's give it a try, c'mon." He doesn't, but the vibration in Simon's chest when he speaks seems to distract him momentarily, enough that his crying stops for a split second, before returning to its high pitched wail. It’s a shocking sentiment. A startling discovery, one that burrows deep, slides under his skin, slicing him open. Could his son really be soothed by his own voice?

“I wasn’t there when you were born.” He smoothes a hand over the top of Orion’s head. “I didn’t know about you, but that’s not mama’s fault, daddy kind of… disappeared, and she didn’t deserve that. I should’ve been there. I know it was probably scary, for both of you.” The wailing and shrieking turns into a mewl. “I’m gonna make it up to you, and her, everyday, I swear. ‘m gonna keep you safe, you and mama, watch you grow, go to school, lose your first tooth. I’m gonna be there for your birthday parties and holidays, as much as I can.” Orion stares at him with wet, tearful eyes, cries turned to quiet whimpers. “Daddy doesn’t have a… normal job, but we’ll make it work, won’t we? You’ll see. I’ll always be here for you, bub.” The broken cries and whimpers almost stop all together, and Simon’s heart glows with pride. He did that. “That’s better, huh? Let’s go see if we can get you to eat something before bed, alright?” He keeps up a steady murmur, pushing open the door to your room, expecting to see- hoping, to see you just out of the shower, but instead-

he finds you in an oversized t shirt and panties, curled up on top of your blankets in bed. A wet towel sits crumpled on the floor, a pair of pajama pants lying on the bed frame by your feet. It looks like you did plan on making it out of the bedroom, but succumbed to your exhaustion instead, and he doesn’t blame you. Today was hard.

“Sweetheart.” He rubs your shoulder, mattress dipping with his weight. Your eyes open, bleary and confused, a question etched across your brow. “Hey, you fell asleep.” You nod, still not with it, lashes fluttering.

“‘m sorry. Baby?”

“He’s right here. Got him calmed down, think he’s ready to eat though.” You yawn, pawing at your shirt, trying to tug it up over your head, eyes closed again. “Alright, I’ve got it, here-“

“Did I miss dinner?”

“No honey. I put it in the oven to keep warm. When you’re ready I’ll bring a plate in f’you, alright?” You sigh, sleep drenched like your lungs are wet, ponderosity sunken in across your body. He thumbs your temple, trying to rouse you a bit more, urging you to roll onto your side, tucking Orion in next to your breast. It must be instinct, the way he finds you in the dark, and you breathe deep once he settles.

“Sorry I fell asleep.”

“You’re exhausted, mama.” Ry makes a little ‘k-ahh’ sound, like a soft puff of air, and you tug at your shirt half heartedly, trying to shuck it upward again. “Do you want this off?” He fingers the hem, and you nod, lifting an arm as he maneuvers around you and the baby.

Bloody hell. You’re a sight, only in your underwear, Orion at your chest. The hall light dips and drags over your body, painting you in yellows and shadow, broad brushstrokes of a goddess splayed out in front of him, feeding his baby.

He can’t tear his eyes away.

“What is it?” You croak, his fingers tracing the valley of your hip and stomach in an answer.

“You’re stunning.” He cradles the back of Ry’s head, leaning close, brushing his nose against yours before kissing you slow, letting it linger, losing himself in the moment.

“You’re not so bad yourself.” You hum into his mouth, still dewy from the shower, fresh spring rain falling from your lips. You’re more awake now, unhurried and sweet, and he slips to his knees at the edge of the bed, smoothing his hand over your shoulder and down your waist. The rolling meadow of goosebumps chasing his fingertips heats his blood-

Until your stomach rumbles. He chuckles. “Hungry?”

“A little.” You cup the back of Ry’s head and nod sheepishly.

“Okay.” He kisses you again because he can’t help it, can’t stop himself or hold back, the physical ache of being so close, yet so far away drives him to touch you, feel you, as much as he can. Before he’s gone. “Sit tight. I’ll get your dinner.”

Later, after he’s fed you (by hand, lifting a fork to your lips over and over as you sat like a perfect little kitten, propped up on a pile of pillows) while Ry nursed, and then put him down, cleaned up the dishes, and placed the baby monitor in its usual spot, he leans over you in bed, where you’re nestled under the blankets, sleepy and sweet. “Hey sleepy girl.”

“Hi.” You whisper, snuggling farther into the covers. “He go down okay?”

“Like a champ. Think he tired himself out with all the yelling earlier.” He presses a thumb to your bottom lip, sliding it back and forth before cupping your cheek. “Get some rest, I’ll get him when he gets up in a few hours.” He jerks his head towards the living room, where he usually takes his post before heading back, a block over, and then anxiously tosses and turns in bed until he hears from you in the morning.

He shifts closer to press his lips to your forehead, but you grab his wrist, grip tight, and there’s a hitch in your breath, a reedy, fragile thing that strikes his heart with bullets. “It’s supposed to get easier.” A tear tracks down your cheek, and he wipes it with his thumb.

“Oh sweetheart, it will. I promise it will.” He tries to soothe you, taking the hand that’s cemented to his wrist and interlacing his fingers with yours. “Postpartum is hard. You have to give yourself a break.”

“I know, it’s just… sometimes I feel like someone else should have been his mum,” your voice breaks, his stomach pitches, heart pounding in his ears. He could drown in the guilt, slip beneath the swell and fill his lungs with it, sink to the bottom with its weight. “Like he was meant for someone else, like someone else would be better. I was so sick when I was pregnant, and when he was born it was… traumatic…” you trail off, desperate, glassy look falling over your eyes before you close them, hand shaking in Simon’s grasp. He wants to wipe it all away, wipe it clean and fix it, patch the gaping wound he left. “Sometimes all he does is look at me and scream, like I’m a stranger. Like he doesn’t… love me, know me. Why aren’t I good at this?” Your chest is stuttering now, short breaths being choked off with sobs, and pulls you into his chest.

“You are good at this, mama.” He kisses your temple. “It doesn’t feel like it, because your head is a little… messed up with all the hormones and changes, but our son is healthy, and happy. He’s safe. You did that. You took care of him all on your own.” You’re still crying, tears spilling over your cheeks, and Simon cradles your face. “I’m so, so sorry I wasn’t here sweet girl. I’ll never forgive myself.”

“It’s not your fault.”

“It is. I’m the one who left you like a… like a ghost. I’m the one who didn’t care about the consequences and left you to face it on your own. You didn’t deserve that, and I don’t deserve you or that boy… but I’m going to try to do everything I can to make it up to you. I’m here, okay? You’re not doing this alone anymore. I’m here.” And you’re never getting rid of me. He doesn’t say it, not willing to disrupt the clearly fragile equilibrium of your emotions, but he feels it all the same. “Orion was meant to be yours, ours. No one else’s. You understand?” You nod, lower lip trembling. “Tell me, mama. Tell me you know our baby loves you like you hung the moon in the sky.”

“I- I know.”

“Come here.” He keeps you in his arms, settling back on your mountain of pillows, keeping a palm at the back of your head, other one rubbing up and down your spine. “That’s what you are. The moon. You and Orion, moon and stars. My moon and stars.” You manage a watery sigh, and then burrow your face into his chest, finally calm enough to take some long breaths, seconds turning to minutes as he holds you in the dark.

“Stay.” You whisper against him, nearly asleep again, and he answers with a kiss to the top of your head.

“I will. I promise.”

[icaruspendragon]

was telling my therapist about how i've always used books, fanfic, and storytelling as escapism but now instead of me consuming stories, stories consume me. dalton gave me The Look (the one that means he's gonna say something i need to hear but don't want to) before asking, "you know that snake that eats itself?" to which i said, "yeah, ouroboros." and he replied, "i didn't know he had a name, that's cool. anyway, you're the snake. i know you've convinced yourself the consumption is filling, but it's not. when it's you you’re eating, it's destruction."

like yeah i know that’s not what the snake represents and ex-cowboy-turned-combat-vet-turned-trauma specialist dalton probably does not know the exact symbolism behind it but like. jesus christ man did that to lay me to waste at 10:30 on a wednesday morning.

and even though he hurt my feelings with the truth, it did put it into perspective for me.

it’s not levity’s lighthouse guiding me to port when depression’s darkness and anxiety’s turbulent waves make it difficult for me to sail smoothly on my voyage.

it’s not a way to alleviate my symptoms, it’s a manifestation of them.

it’s a compulsion, deceptively insidious when cloaked in distraction’s pseudo-warmth. when easily covered by procrastination’s much easier to swallow explanation.

and i’m sure you want to say “but reading is a healthy coping mechanism!”

and it is. when done in moderation.

it’s no longer coping when your screen time is 16 hours a day. when 12 of those hours a day are spent scuttling about ao3 on all fours. when you sit in the same spot on the couch for hours on end with your head buried in the sand. when it’s literally all you can think about.

the consumption isn’t coping. isn’t creation. isn’t reconstruction or rebirth or reformation. it’s chaos. it’s compulsion.

it’s cannibalism.

[mcverse]

ꨄ︎ Paring: Neteyam x Avatar! F! Reader

ꨄ︎ Requested: Yes/No

ꨄ︎ Type: Part 1 out of 5 (Previous/Next)

ꨄ︎ Word count: 2.3K

ꨄ︎ Warnings: Death, conscious transfer, illness, depression, angst, not spell checked

ꨄ︎ Side Bar: Lied bout how many parts ✌️

please keep in mind that all characters in my stories are always 18+

You were the fault in the stars—an anomaly right from your first breath.

The sky people, who technically were your own, had descended upon Pandora with a singular intention of seizing what was not theirs, continuing the vicious cycle of destruction and resolution that had marred their history.

In the midst of this chaos, your parents, two faceless soldiers whose names and faces are shrouded in a haze of pain and heartache, had their own hidden agenda that they pursued with reckless abandon.

Their clandestine romance, born out of passion and desperation, resulted in your fragile birth—a constant reminder of their illicit love in a world that will struggle to accept you.

Much like spider, whom you considered your own brother now, the two of you were both deemed too young for cryogenic preservation and left behind on the unfamiliar terrain of the alien planet.

Unfortunately unlike Spider, your body was weak, afflicted with a genetic strain inherited from one of your biological parents. Perhaps this, among other factors, contributed to the decision to abandon you on Pandora, leaving you to face the harsh realities of survival alone.

Despite your rational understanding of the circumstances, as you came to accept the voice in your head as your own and not a figment of your imagination, the unjustness of their decision still lingers within you.

It certainly wasn’t fair.

Your delicate condition left you confined to the high camp, unable to roam freely and appreciate the majestic wonders of Pandora like Spider. Every step you took was accompanied by painful bouts of coughing, requiring you to rely on a specialized oxygen mask designed to alleviate your symptoms.

Even within the safety of the base built for humans, the air meant to sustain you offered no respite. Such was the irony of your existence, born into a world where both forms of air you breathed posed a constant threat to your survival. Life had thrown you a curveball long before you even knew what it meant.

But it wasn't all doom and gloom.

Although you were too young to return to Earth and too ill to venture far from your room, you seized the opportunity to explore what was within your reach. Every video log, every movie, and every book, left behind by the sky people, some of which a child shouldn’t have access to was reviewed by you to fill in the absence of adventure in your day.

For a while, it was sufficient, and you gradually came to terms with the inevitability of your fate. There was no cure for your ailment, not on Pandora, and certainly not without the funds to obtain one. You accepted that you would die here, in this place, as you.

It was during this time that you became fascinated with the study of physiology, absorbing every bit of knowledge about your own body and how it could have been saved under different circumstances. You spent countless hours researching medical practices and surgeries, diving deep into your own anatomy and discovering how various medications and herbs could extend or improve life.

Sharing your newfound knowledge with Spider, Lo’ak, and Kiri became a daily ritual that brought you joy and excitement. You would eagerly offer up fascinating facts to the Sully children and Kiri whenever they stopped by to visit or fetch your brother.

Though they didn't always grasp the intricacies of physiology like you did, they were just as enthusiastic to learn and would often opt to stay cooped up in your room, asking questions both silly and serious, and enjoying the happiness that radiated from you.

The moments spent with Spider, Lo’ak, and Kiri in your room were some of the best memories you would always treasure. It was through your eagerness to share your newfound knowledge and energy that you got to know them better, especially Kiri, who became your closest friend and confidante. You were so close that she was like a sister to you, always by your side.

However, the limitations imposed by your illness often left you feeling lonely and isolated when your friends were not around. Your physical limitations reminded you that you had a faulty body that was unable to explore the vast world of Pandora like they could. And that is where you messed up.

You fell into a deep depression, which gradually turned into a false sense of determination. You felt like you could survive out there like Spider, or rather, that you wanted to. What was the point of living if you had to live with this feeling of not being in control? It was actually pathetic.

It was a reckless decision to leave the safety of your home and venture into the forest, following the group of newly-adults, taking care to move slowly so as not to cough and give yourself away. It was even worse when you brazenly entered the Omaticaya clan, knowing full well that you were a stranger and seen as an enemy of the natives.

Being surrounded by creatures larger than you, most of them hissing and armed with weapons, was overwhelming. Panic set in, causing hyperventilation, which was exacerbated by your illness. Despite the mask, it was difficult to breathe, doing very little to keep you conscious and your eyes began to roll to the back of your head.

You welcome the darkness, craving the peace it brought, but never enough to end your life yourself. In that moment, you felt alive for once, and you never wanted to leave. You had no desire to return to the life you once had.

But things don't work that way, and eventually, your eyes flutter open. For a moment, you're disoriented, you wonder if you're still gone—whether you're dead or just existing to not exist. Your vision is still blurry, but as you blink and flicker your eyes, the colors of glowing, bioluminescent blue slowly come into focus.

The sight before you is truly breathtaking. The glow emanating from the tree mesmerizes you and fills you with a sense of wonder and awe. As you gaze at it in rapture, you feel an intense urge to touch it, to feel its warmth and energy. You reach out your hand, but to your shock, the hand that extends is not yours.

The hand that hovers before you is large, bony, and blue, with five fingers like yours. Confusion and bewilderment seize you, and you stammer out a feeble, "W-What?" as you try to make sense of what is happening.

As you stare at the mysterious blue hand, your eyes widen when you see another identical hand firmly grasp on the blue hand hovering before you. It's not just a visual illusion—you can feel the pressure on your skin. Slowly your eyes follow up the arm of the mysterious hand to find Kiri smiling softly at you, tears glistening in her eyes.

The sight of her tears immediately worries you, filling your head with warning bells and you return the squeeze, “Kiri, what’s wrong?” you ask, voice oozing in concern.

She returns your concern with a wider smile, her teeth gleaming under the bioluminescent light and shakes her head, “I’m okay,” she assures you, her hand trembling as she continues, “It’s just… to see you like this makes me so happy.”

Confusion etches on your face as you furrow your brow, struggling to comprehend Kiri's statement, "See me like what?" you mumble, tilting your head quizzically. Your eyes dart back to the now intertwined hands before you, trying to make sense of what you're missing.

As you feel Kiri's hand on the other bony blue hand, you can't help but notice that it's not your own. The hand is obviously Na'vi, which you are not. Your mind is filled with unanswered questions, and the nagging feeling of not understanding the situation consumes you. You look back at her, repeating your question with a sense of urgency, "What do you mean, Kiri? When you say 'see you like this', what am I like?"

Kiri kneels down beside you, and you feel her release your hand. She slides it up your arm and firmly grasps your bicep, while her other arm reaches around your upper back and uses all her strength to pull you up into a sitting position. You're momentarily discombobulated, realizing you must have been lying down before, but you can't remember when or how you ended up in that position.

“You fainted,” she replies softly after a beat of silence, pulling on you slightly to lean more on her. You look up at her, mouth slightly agape at her words, “You almost died,” she continues, brows frowning like her lips, “We almost lost you.”

The weight of her words hits you hard, and you feel a lump form in your throat. You inhale sharply, only to realize that when you do, your lungs contact and flatten smoothly without a following cough. It's a strange sensation, and you can't help but marvel at it for a moment, grateful to be breathing easily again.

Then your attention is back on Kiri, eyeing her questionably, as you notice something strange, “Did I grow or have you gotten shorter?” Whether it was sitting or standing, Kiri is normally seen towering over you by several feet, but right now she’s exactly the same level as you.

Kiri's expression twists into a grimace, and she opens her mouth to answer, but before she can speak, another voice cuts in, firm and straight to the point, “No! You have passed through the eyes of Eywa and returned.”

Your gaze shoots up to the source, and you find yourself gazing into the piercing yellow eyes of a female Na'vi standing before you. They felt as if she was looking straight through you, leaving nothing hidden or unexamined. Immediately your struck by the intensity of her. There's a raw power to her presence that feels both intimidating and awe-inspiring, as if you're standing before a force of nature.

“Come again?” you stutter, worry slowly creeping up on you as you are once again confused by another statement. You weren’t understanding a lot of what was going on right now. You tear your eyes from her to look back at Kiri and raise your brows at seeing Lo’ak and Spider now standing behind her.

When did they get there?

“What does she mean? Who is she?” You whisper hurriedly to your best friend, glancing occasionally at the boys, hoping if Kiri doesn’t give you the answers you want, they will.

“[Name],” another voice speaks, calling out to you. You perk up at it, instantly recognizing it to be Norm, which it was when you find him standing in his avatar body beside the mysterious woman from before. He walks closer to you, kneeling when close enough just like Kiri, “Sweetie, when you fainted, you stopped breathing for a few minutes. Jake called Max and I to help.”

Jake. That’s Kiri and Lo’ak’s dad. You’ve only met him once when he was stopping by to talk to Norm. He was really sweet and made you feel normal just like his kids.

“Okay…” you stare at him warily, waiting for him to get to the point.

He looks away briefly, seemingly to gather his thoughts before looking back at you, “Max and I know more than anyone how much you’ve been struggling. So even though we didn’t have the resources before, we were determined to help you,” he pauses as Max comes up behind him and beam at you, “We started making you an Avatar 6 years ago. Some test still needed to be ran but we’re out of time.”

You push away from Kiri slightly, lips forming a tight line as your squint at him, “What are you trying to say, Norm?” A part of you knew deep down, but the denial was heavy, to think you could be like everyone else, no illness or restrictions was a myth.

“You’re human body died, you are now consciously living in your avatar.”

His words caused a reaction, albeit a slow one. First your lips start to quiver, and your body trembles in disbelief before tears pool at your eyes. Kiri quickly wraps you in her arms, laying her head on top of yours as you lean your face into her to conceal your choked sobs.

To think something you had dreamed about has actually came true. The many nights you stay up, coming up with solutions to you, the problem. You didn’t know what else to feel, if not relief beyond the depths of your soul.

“Eywa has gave you a second chance,” Kiri mutters lowly, but it was loud to you as her hot breath fans your ears and cause it to twitch, “I’m so happy for you, [Name].”

This time you pull away from her completely, smiling up at her with glossed over eyes and chest filled with so much warmth, you might overheat, “Thank you, Kiri.” Slowly, you rise up from your sitting position with her help. You were stunned at the distance from the ground at full height. This was going to take some time to get used to.

“Max, Norm… Thank you, I can’t express that enough.” You try to walk to them, but your legs were wobbly so you more like stumble instead. Eventually, you reach them and pull them both into a hug, which probably looked silly as Max was the shortest by far in the bunch.

“You being safe and healthy is enough.” Max says, being the first to pull away and Norm nods, agreeing with him as he pulls away next, “We still have to run test though.”

You chuckle at that, rolling your eyes as you nod to him, “Understood.” You didn’t care how many test they had to run, as long as you were able to run and breathe without falling over.

Run.

You wanted to run.

Your ears flicker at the thought, stalling your side quest as your attention is drawn to them. You went to grab them in awe and felt something swish behind you, “Huh?” You twist your body, wait a second, and laugh when your eyes land on a tail; your tail, “Amazing!” You exclaim, smile growing wider.

Someone clears their throat, successfully making you stop and look at who did. To your surprise it was Jake, who was standing by the female Na’vi from earlier. He too had a smile on his face, happy to see you back and better than ever.

Though he haven’t spent much time with you, he was sympathetic to your situation, as it felt somewhat similar to his past self and unknowingly to you, have allowed Norm and Max to create a Avatar for you. It was only a matter of time before you became one like him.

“How are you feeling?,” he smiles warmly at you, like a father does his child. It made you feel giddy and shy, “It might feel strange at first, but you'll get used to it.”

You give him a curt bow, afraid to look him in the eyes. Before it was easy, it just felt different now. You couldn’t explain it, you just knew, “Thank you, it feels… different but I’m still me.”

He nods, walking closer to stop a foot away, “Good… [Name], you are Na’vi now. That means you have the opportunity to become apart of the Omaticaya clan.” He raises a hand and places it on your shoulder.

You knew what that meant. That means you’ll have to complete rites to become one of them. But that was the least of your worries; you knew nothing out the land except from what you read or what Norm brought back and you didn’t know how to hunt or fight for yourself. There was no way you can pass.

As if he can read your mind, he points to a male Na’vi, much younger than him with braided hair and sharp features. He resembles a handsome sculpture you read in history books, but better, “My son, Neteyam, will teach you the way of Na’vi.”

“Dad,” Lo’ak steps forward to protest but gets shut down with one look, his eyes cast down and he steps back into the background.

Poor Lo’ak, you thought, didn’t even stand a chance.

“Neteyam is a good teacher and warrior. You’ll learn fast.” Jake tells you, proudly.

“T-Thank you.” You bow again, much deeper this time. You didn’t know why you were bowing or if it was even appropriate in this situation, you just read somewhere that it was respectful.

He nods again, turning away to walk over to his son, the one he calls Neteyam. He whispers something to him, something that causes his lips to form a tight line and look over at you in annoyance as his dad leave him there.

You flinch at that and look away abruptly, just now taking notice how there were a whole ton of Na’vi circling around you all. How overwhelmed must you’ve been to not notice?

Suddenly, the air was knocked out of you temporarily as a force hits your stomach. Looking down, your body relaxes when you see it’s Spider. It was a little weird to be the taller one this time, but that didn’t stop you from returning his hug.

“Do that again and I will kill you!” He spits, glaring up at you in faux aggression. His hold on you, along with the pout on his lips tells the opposite of his words, “Scared the hell out of me.” he eventually admits, glare softening a great deal.

“That’s the opposite of what we want, bro.” Lo’ak comes up beside you and swings his arms over your shoulder, pulling you into a side hug of some sort, “But if you do, I’ll team up with him to make it happen.” He teases, smirking at you.

Kiri comes up from behind to push him off you, replacing his arm with hers around your waist, “Over my dead body,” she rolls her eyes and cheese at you, “I can’t wait to show you pandora. You’re going to love it,” she says, tugging you with her towards the forest, “Come on.”

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[aspd-culture]

Sorry ig in advance since you get questions a lot but got curious about a few things

1. Is it normal for pwASPD to view unbeneficial relationships as chores? I know I, a likely prosocial, when I don't see the benefit in a relationship, I have to view it as being a chore to continue it.

2. If a connection is established between harming others and being harmed, will a pwASPD, for lack of a better term, be able to mimic empathy or remorse?

3. Do you know if pwASPD and another comorbid disorder, if the other disorder causes already low or fragile self esteem (like another cluster B), can seem like they don't have ASPD?

These are mostly for project research but also out of curiosity because I can

Nothing to be sorry for!!/gen

1.) Oh yes. So very, very much yes. And honestly, it's even worse than a chore - more like if a dead-end job decided to stop paying you but you'd go to jail if you quit. If you've ever seen a kid stuck dress shopping with their mother on TV, that's the way I would like to act through every single interaction with an equal part useless and annoying but unavoidable prosocial irl. Every single non-Exception prosocial is that coworker you hate who won't leave you alone./hj Joking aside, not all prosocials are actually that annoying actually. So it kind of depends; sometimes it's fine at least for me.

2.) Yeah, I'd say so. This goes differently for all of us, but for the most part "connection formed" would probably go in the direction of an Exception, and that's where some symptoms of ASPD are lessened for those of us that have them. That includes often having some degree of effective empathy and/or a desire to work on cognitive empathy with them in particular (I use them as practice to make the necessary use of cognitive empathy less annoying with non-Exceptions). Ditto with remorse for some pwASPD, though for me in particular that depends on the Exception in question. Some still do not bring out remorse in me for whatever reason. This is a good place to note that actually, since I don't think I've mentioned this elsewhere. Exceptions do not all have to be the same even for the same pwASPD. Two friends may have different symptoms they alleviate vs don't affect vs worsen, and of course platonic vs sexual vs romantic Exceptions often vary in that as well. For me and a few other pwASPD I've met, this may also occur with some groups of people who aren't Exceptions but cause an Exception-esque response. For me, kids get that as most do other people struggling with mental health disorders beyond just depression and anxiety (nothing easy about those two it's just in our current world most people have those). If I hurt a kid's feelings, 25/10 times I am going to cry with them or force myself not to. And that will vary for each pwASPD based on how much social neurological development was completed before it was fundamentally changed and started developing antisocially too. Some of us have more empathy than others, or more remorse than others (and vice versa) in general, so that'll impact those situations too.

3.) So this depends on what you define as "seem like they don't have ASPD", though it won't be self-esteem that affects that. Generally I'd point that more in the direction of NPD. But yeah, looking at the symptoms of ASPD, there are a few specific disorders that cause someone who very much has ASPD to not be diagnosed and/or believed both professionally and personally. In personal relationships, it's honestly just not being a serial k*ller that will get most to think you don't have it. Professionally, you're looking at disorders that cause social problems (such as autism, SAD - social anxiety, and GAD - generalized anxiety), impulse control (ADHD mostly), emotional instability (bipolar disorder, IED - intermittent explosive, ODD - oppositional defiance, and yeah your other cluster b PDs). There are others that make a whole lot less sense imo to get in the way of an ASPD diagnosis too. Schizophrenia comes to mind, with some professionals thinking that it's just... so many episodes of psychosis that it starts to look like ASPD which, don't even get me started on how much of a medical failure it is that I have heard of that specific thing happening. But mostly, it's going to be the ones I listed previously. None of these are mutually exclusive with ASPD, but they have symptoms that overlap with or mimic ASPD's, and so you'll have genuinely good professionals who are trying to avoid over/misdiagnosis where it applies to a *very* stigmatized disorder, and you'll have lazy ones that don't care to try and pick out which it is if not both. That will all just depend on the pwASPD's presentation of symptoms. I had more than one professional refuse to believe I had ASPD, and my (very lovely and dilligent/gen) psychiatrist was also leaning to just diagnose autism until I said some line about the reason I try for social interaction not being because I want to but because everyone has to to be able to get what they need in life. Once she realized I see it as an irritating requirement to associate with other people - even ones I kind of like - she quickly turned on that and diagnosed both. That's why it's important to speak openly and with as much of the mask removed as possible without getting yourself in trouble. They will try and avoid labelling you with something like this unless they are 1000% sure because of its connotations and the social and professional implications of having ASPD. It is very possible to pick out which is which or if it's more than one with overlap in regards to any set of comorbidities even outside of ASPD, but it takes a lot of work for that to be done properly especially if you're still masking in front of them.

I have no issue with anyone asking just out of curiosity by the way. Seriously like I guess I see why some people feel weird about it, but genuine interest is the reason why disorders get looked into, researched, and potentially normalized and accepted. There is nothing wrong with being interested in any topic as long as you're respectful in your interactions with sensitive subjects, and this ask was completely respectful, so I'm happy to answer it./gen

Plain text below the cut:

Nothing to be sorry for!!/gen

1.) Oh yes. So very, very much yes. And honestly, it's even worse than a chore - more like if a dead-end job decided to stop paying you but you'd go to jail if you quit. If you've ever seen a kid stuck dress shopping with their mother on TV, that's the way I would like to act through every single interaction with an equal part useless and annoying but unavoidable prosocial irl. Every single non-Exception prosocial is that coworker you hate who won't leave you alone./hj Joking aside, not all prosocials are actually that annoying actually. So it kind of depends; sometimes it's fine at least for me.

2.) Yeah, I'd say so. This goes differently for all of us, but for the most part "connection formed" would probably go in the direction of an Exception, and that's where some symptoms of ASPD are lessened for those of us that have them. That includes often having some degree of effective empathy and/or a desire to work on cognitive empathy with them in particular (I use them as practice to make the necessary use of cognitive empathy less annoying with non-Exceptions). Ditto with remorse for some pwASPD, though for me in particular that depends on the Exception in question. Some still do not bring out remorse in me for whatever reason. This is a good place to note that actually, since I don't think I've mentioned this elsewhere. Exceptions do not all have to be the same even for the same pwASPD. Two friends may have different symptoms they alleviate vs don't affect vs worsen, and of course platonic vs sexual vs romantic Exceptions often vary in that as well. For me and a few other pwASPD I've met, this may also occur with some groups of people who aren't Exceptions but cause an Exception-esque response. For me, kids get that as most do other people struggling with mental health disorders beyond just depression and anxiety (nothing easy about those two it's just in our current world most people have those). If I hurt a kid's feelings, 25/10 times I am going to cry with them or force myself not to. And that will vary for each pwASPD based on how much social neurological development was completed before it was fundamentally changed and started developing antisocially too. Some of us have more empathy than others, or more remorse than others (and vice versa) in general, so that'll impact those situations too.

3.) So this depends on what you define as "seem like they don't have ASPD", though it won't be self-esteem that affects that. Generally I'd point that more in the direction of NPD. But yeah, looking at the symptoms of ASPD, there are a few specific disorders that cause someone who very much has ASPD to not be diagnosed and/or believed both professionally and personally. In personal relationships, it's honestly just not being a serial k*ller that will get most to think you don't have it. Professionally, you're looking at disorders that cause social problems (such as autism, SAD - social anxiety, and GAD - generalized anxiety), impulse control (ADHD mostly), emotional instability (bipolar disorder, IED - intermittent explosive, ODD - oppositional defiance, and yeah your other cluster b PDs).

There are others that make a whole lot less sense imo to get in the way of an ASPD diagnosis too. Schizophrenia comes to mind, with some professionals thinking that it's just... so many episodes of psychosis that it starts to look like ASPD which, don't even get me started on how much of a medical failure it is that I have heard of that specific thing happening. But mostly, it's going to be the ones I listed previously. None of these are mutually exclusive with ASPD, but they have symptoms that overlap with or mimic ASPD's, and so you'll have genuinely good professionals who are trying to avoid over/misdiagnosis where it applies to a very stigmatized disorder, and you'll have lazy ones that don't care to try and pick out which it is if not both. That will all just depend on the pwASPD's presentation of symptoms. I had more than one professional refuse to believe I had ASPD, and my (very lovely and dilligent/gen) psychiatrist was also leaning to just diagnose autism until I said some line about the reason I try for social interaction not being because I want to but because everyone has to to be able to get what they need in life. Once she realized I see it as an irritating requirement to associate with other people - even ones I kind of like - she quickly turned on that and diagnosed both. That's why it's important to speak openly and with as much of the mask removed as possible without getting yourself in trouble. They will try and avoid labelling you with something like this unless they are 1000% sure because of its connotations and the social and professional implications of having ASPD. It is very possible to pick out which is which or if it's more than one with overlap in regards to any set of comorbidities even outside of ASPD, but it takes a lot of work for that to be done properly especially if you're still masking in front of them.

I have no issue with anyone asking just out of curiosity by the way. Seriously like I guess I see why some people feel weird about it, but genuine interest is the reason why disorders get looked into, researched, and potentially normalized and accepted. There is nothing wrong with being interested in any topic as long as you're respectful in your interactions with sensitive subjects, and this ask was completely respectful, so I'm happy to answer it./gen

[rarebird22]

Some insight on my personal religious beliefs and why I think some recent statements my church made are absolutely, mind-bogglingly WRONG:

(warning: there is, unfortunately, a lot of transphobic stuff in the publication my church made. I'm including my summary here for people who don't know about it, but it could possibly be triggering. if there's a better way I could be doing this, let me know. Basically they're choosing to make some dumb restrictions to trans people's participation in the church. It's unchristlike and I wanted to comment on it.)

(my comments are listed in parentheses. Everything else is quotes or summary.)

Potentially transphobic quotes start below:

“Gender is an essential characteristic in Heavenly Father’s plan of happiness. The intended meaning of gender in “The Family: A Proclamation to the World" is biological sex at birth.”

The church doesn’t have an official stance on why people experience gender dysphoria.  They make a separation between experiencing dysphoria and “identifying as transgender.”

“[Transgender people]—and their family and friends—should be treated with sensitivity, kindness, compassion, and Christlike love. All are children of God and have divine worth.”

(If this is true, why doesn’t this policy seem to show Christlike love and compassion?  Denying participation to some children of God doesn’t seem like what Heavenly Father would want, especially when the reason for the exclusion is an intrinsic part of someone’s identity.)

“Church leaders counsel against pursuing surgical, medical, or social transition away from one’s biological sex at birth.  Leaders advise that taking these actions will result in some Church membership restrictions.”

(I believe this policy in particular is incredibly harmful.  Many, many studies have shown the positive effect of transition on alleviating gender dysphoria, reducing symptoms of depression, and preventing suicide.  My own family members have explained how medical and social transition improved their mental health better than anything else they tried.  Just as appropriate medical care is important for the wellbeing of trans people, so too is a loving, supportive network of family and friends.  This policy sets up a false dichotomy between community support and personal authenticity, forcing trans church members to undergo incredible levels of distress as they decide between remaining as a fully participating member of the church or undergoing the changes that help them become who they truly are.)

According to the church handbook, anyone who has transitioned in any way cannot participate in saving ordinances, which are “received according to a person’s biological sex at birth.”  Exceptions can be made for baptism with the approval of the first presidency, but not for priesthood ordinances or temple recommends. The handbook also says that leaders should “address individual circumstances with sensitivity and Christlike love.”

(It is good to show Christlike love, but what freedom is there to lovingly address individual circumstances when this policy places such exclusionary limits on transgender individuals’ participation in the church?)

“Individuals who transition away from their biological sex at birth are welcome to attend sacrament meetings and participate in the Church in many other ways.”

The handbook’s recommendations for how trans people can participate include attending church meetings and activities, participating in family history work, and providing service to others.  The handbook then includes a link to a document with “guiding principles” for trans people’s participation in church.  The document lists that leaders should:  “Seek spiritual guidance; Treat individuals and their families with love and respect while teaching gospel truth; Consider the needs of the individual and other ward members; Ensure that the Church’s doctrine on gender is not undermined or misunderstood; Seek counsel [from other leaders]; and Involve the parents or guardians of minors.”

(The part about being careful not to undermine the Church’s doctrine on gender is what stands out to me and concerns me the most.  Based on this line, it seems to me like the primary purpose of all these changes is to maintain the church’s historically accepted norms.  Any search about the doctrine of gender within the church’s website will always lead to the same phrase: “Gender is an essential characteristic of individual premortal, mortal, and eternal identity and purpose.”  Apparently this phrase is the church’s doctrine about gender.  That makes me wonder, though, because the Family Proclamation is a newer document that has an ambiguous state between scriptural canon and church policy.  Perhaps that phrase has been misinterpreted due to cultural lenses.)

The Guiding Principles document states that someone’s preferred name can be noted on their church membership record.  It also places restrictions on trans individuals’ participation in the church.  It says that people should attend the meetings, activities, and camps that match their biological sex at birth.  Some exceptions can be made for meetings and activities, but not for overnight camps.  In addition, youth who have transitioned in any way aren’t allowed to stay overnight at mixed-gender activities like youth conferences.  Trans people can’t hold callings that are gender-specific or involve caring for children or youth or teaching.  They are also asked to use a single-occupant restroom, a restroom that matches their assigned sex at birth, or be the only person in a restroom.

(All of these policies are problematic to me.  The policies about overnight activities feel exclusionary and could lead to ostracization of trans youth.  The policies about gendered activities and meetings feel like they place unnecessary emphasis on differences between men and women, which makes me uncomfortable.  The restriction against teaching makes me feel especially hurt and angry, because to me this is a silencing of trans voices.  This policy says “we do not want the perspectives of trans people to be shared in our church.”  And the restroom policy is based on outdated and unfounded fears that associate trans people with predatory behavior.  That’s a sad stereotype to perpetuate.)

4. My conclusion

(I don’t think these new changes live up to the Church’s ideals of showing Christlike love to everyone and inviting all to come unto Him.  While it doesn’t say so explicitly, the handbook seems to consider transgender identity as a personal label and choice.  Every trans person I’ve met says otherwise.  Being trans is a core part of so many people’s life experience.  While I, like the church, don’t know why some people are transgender, I do believe that trans people should be treated with the same dignity and respect as anyone else.  The church’s new policies seem to do the opposite, treating trans people as “other” and restricting their ability to participate in the church.  The church has already caused so much heartbreak and despair among trans people, who understandably see past and current policies as evidence that something is wrong with them.  As representatives of Christ, it is not appropriate to send that message - directly or indirectly.  Instead, the church should be focusing on how we can reflect the true nature of Jesus Christ.  He sacrificed his life to bring redemption and salvation to every single one of God’s children.  He spent his mortal ministry interacting with those who leaders of his time considered different or unworthy.  Every aspect of His life shows his infinite love.  If the Church of Jesus Christ of Latter-day Saints truly wants to live up to His example, love and inclusion for ALL of God’s children - including trans people - is essential.)

[plumlace]

Mental Wellness Mod Beta Testing

Today for beta testing I am releasing my Mental Wellness Mod! I'm really appreciative that you guys are here and I want to share this with you.

I want to iterate that this is not a completed mod. I would like feedback, ideas, and suggestions from you to make this the best possible mod. Below I will outline the current features.

Mental Illness

Anxiety

Depression

ADHD

Each illness adds a constant buff to sims, and some illnesses have random buffs such as anxiety attacks or hyper-focus.

Taking medication will also give you a buff that alleviates symptoms. Some medications have a chance for different types of buffs, such as a dazed buff.

You can use the cheat menu to diagnose each condition or remove conditions.

You can become diagnosed by going through an assessment with a Psychiatrist. You will then be prescribed medication based on your diagnosis.

All sims have the option to speak with a therapist and receive a buff afterwards.

You can choose to use the phone or walk through the pie menu to speak with a therapist or psychiatrist.

You can also discuss your mental health or vent to other sims. You do not need to have a diagnosis to do so.

This is just a general overview of the mod I'm currently working on. I am requesting beta testers to test the mod out and provide feedback before posting publicly. This is not a complete mod.

If you are interested in beta testing, become any tier Patron and DOWNLOAD HERE.

Thank you so much!

[remindingpersephone]

Here we go again

Hi gang. I'm back on my Chris-Get's-Healthy kick, again. I know I've talked about this and asked for your help in the past. I am once again attempting to quit sugar and work out more.

If you have offered me advice in the past and are tired of my requests, yet again, for advice and ideas, I understand. I get it. Believe me, no one is more tired of my bullshit and my inability to stick to a regimen and make the healthy choices than I am.

This last time I was derailed by my mom's illness and death. I just did not have the mental space or physical energy to commit to disciplined nutritional choices and consistent work outs while taking care of her. But the reasons don't really matter because there were excuses before this one, and on and on. I have been starting and giving up on, healthy living routines since I was 18 years old. Let's do the math, that's 30 years!

A little background: I am not a yo-yo dieter. I very slowly put on weight starting with my first desk job at 20 and never dropped it. The weight has never bothered me. I am a confident woman who has never needed to fit into a six 6. I am also single by choice and nothing in the last 30 years has given me a reason to change my mind about this.

This situation now is that I'm looking hard at 50 and the little aches and pains: the trick knee, the occasional sciatica, the feet that get a little too sore too soon, are, I feel, all red flags signaling that hitting snooze on my health is no longer an option.

I truly believe that fitness and nutritional eating are not only the key to staying fit and active, but I think if I just commit and get through those first few tough months, I would actually like it.

Lately I've been drinking my Dr. Pepper and eating my high-calorie cheesy pasta and lots of sourdough bread (all my favorites), but they just haven't been as satisfying as they once were. [Sidebar: I realize some of this could be residual depression and grief making life just not as wonderful as it once was. That will take time.]

Mostly, I'm just tired of giving the "I have got to get my health in order" thoughts the mental real estate in my brain. I need to deal with it so I can move on from it. So it is not such big part of my daily thoughts.

My long-winded and self-indulgent post here is just to ask once again - and I swear for the last time - what do you all find works for you as far as fitness and nutrition goes? My fitness goals are:

to get stronger and improve flexibility and mobility while protecting the joints and ligaments

staving off osteoporosis

alleviating some peri-menopause symptoms

My nutrition goals are:

to kick the sugar addiction once and for all and change my palate so I don't crave sweet things so much

prevent diabetes/heart disease, etc. before they start

improving gut health

I welcome all comments and advice, and that includes the tough-love "girl, you have got to get your shit together!"

[covid-safer-hotties]

Also preserved in our archive (Daily updates!)

By Nikhil Prasad

Long COVID continues to baffle scientists and frustrate patients. Many individuals who had mild or moderate COVID-19 report persistent symptoms that affect their daily lives. Among these lingering issues, cognitive problems - often referred to as "brain fog" - are widely reported. This Medical News sheds light on a recent study conducted by researchers from the Montreal Heart Institute and the Montreal Health Innovations Coordinating Center-Canada, in collaboration with Inogen in California-USA, that explores whether oxygen therapy could help alleviate cognitive issues in long COVID sufferers.

The Study: Portable Oxygen Therapy in Focus The research team investigated if providing additional oxygen to long COVID patients could help them think more clearly and potentially improve cognitive function. The study involved 21 participants who were given oxygen through portable oxygen concentrators for three hours daily over two weeks. For comparison, they also experienced two weeks of standard care without any supplemental oxygen.

Understanding the Methods Behind the Study Researchers used a variety of tests to assess cognitive function, including the Montreal Cognitive Assessment (MoCA), which evaluates different aspects of cognition like memory, attention, and executive function. They also used tools to measure depressive symptoms, anxiety levels, and functional status. Oxygen levels in the brain and peripheral regions were measured using specialized devices during both rest and treadmill exercise.

Cognitive Test Findings: Improvements in Key Areas One of the most intriguing findings was that participants using oxygen therapy showed slight improvements in cognitive scores on specific tests. The MoCA results hinted at better performance, particularly in areas related to visuospatial/executive skills and attention. These findings align with common cognitive complaints from long COVID patients, suggesting that oxygen therapy might support improvements in attention and mental clarity. However, the overall impact on memory and other cognitive functions was limited, as many patients were already performing within a normal cognitive range at the study's start.

Mood and Mental Health Benefits of Oxygen Therapy In addition to cognition, the study explored how oxygen therapy impacted participants' psychological health. Patients using oxygen reported feeling slightly less depressed than those who did not receive supplemental oxygen. This was particularly noticeable in areas tied to enjoyment of daily activities and the ability to concentrate - both of which are significant struggles for long COVID patients. The study found that portable oxygen concentrators could have a subtle yet positive impact on mental health, reducing some depressive symptoms, particularly feelings of detachment or inability to concentrate.

Oxygen Levels During Exe rcise: No Significant Change Noted The research measured cerebral and peripheral oxygen saturation during both rest and exercise, aiming to see if oxygen levels improved significantly with supplemental therapy. Surprisingly, no substantial changes were observed in these oxygen levels during either period. This suggests that while portable oxygen therapy may help certain cognitive and mental health areas, it does not necessarily boost oxygen levels in the brain or body during physical activity.

Long COVID and Ongoing Mystery of Cognitive Symptoms Long COVID affects multiple body systems, creating complex issues beyond physical symptoms like fatigue. Cognitive symptoms are particularly troubling for patients and can range from simple forgetfulness to severe difficulty with problem-solving and focusing. Current hypotheses on long COVID suggest that oxygen deprivation in brain tissues might be partly responsible for the cognitive issues. This study points towards the possibility that providing more oxygen, even at a portable level, could help alleviate some cognitive symptoms and improve overall quality of life.

Participant Experience with Portable Oxygen Therapy Participants reported positive feedback about the oxygen therapy device’s usability, indicating that the portable concentrators were user-friendly and easy to incorporate into daily life. This acceptance is crucial, as any potential treatment for long COVID must be manageable for patients to use consistently. In total, 70% of participants found the device’s size and weight acceptable, and almost all participants agreed that it was easy to operate.

Conclusions and Future Implications In conclusion, the study highlights the potential for portable oxygen therapy to provide subtle benefits for cognitive function and mental health in individuals struggling with long COVID. While it does not appear to directly impact oxygen saturation levels during physical activity, it may still offer support in specific cognitive and emotional areas. Future research with larger sample sizes and longer follow-up periods is essential to determine the full benefits of oxygen therapy and to confirm these preliminary findings.

The study findings were published in the peer-reviewed journal: PLOS ONE. journals.plos.org/plosone/article?id=10.1371/journal.pone.0312735

[saulwexler]

I feel like because depression is common it tends to get trivialized when it's the actual worst.

this recent study has been going around about how effective exercise is in alleviating depressive symptoms - and it's 100% true like we should all do this!

but at the same time people act like actual symptoms of depression are excuses, and not real barriers to physical activity (insomnia, fatigue, calorie deficit from low appetite, eg).

anyway going on my walk even though it's pouring rain and I will complain the whole time >:(

[maaarine]

The Cause of Depression Is Probably Not What You Think (Joanna Thompson, Quanta Magazine, Jan 26 2023)

"A literature review that appeared in Molecular Psychiatry in July was the latest and perhaps loudest death knell for the serotonin hypothesis, at least in its simplest form.

An international team of scientists led by Joanna Moncrieff of University College London screened 361 papers from six areas of research and carefully evaluated 17 of them.

They found no convincing evidence that lower levels of serotonin caused or were even associated with depression.

People with depression didn’t reliably seem to have less serotonin activity than people without the disorder.

Experiments in which researchers artificially lowered the serotonin levels of volunteers didn’t consistently cause depression. (…)

Although serotonin levels don’t seem to be the primary driver of depression, SSRIs show a modest improvement over placebos in clinical trials.

But the mechanism behind that improvement remains elusive.

“Just because aspirin relieves a headache, [it] doesn’t mean that aspirin deficits in the body are causing headaches,” said John Krystal, a neuropharmacologist and chair of the psychiatry department at Yale University.

“Fully understanding how SSRIs produce clinical change is still a work in progress.”

Speculation about the source of that benefit has spawned alternative theories about the origins of depression. (…)

Repple warns, however, that another explanation for the effects his team observed is also possible: Perhaps the depressed patients’ brain connections were impaired by inflammation.

Chronic inflammation impedes the body’s ability to heal, and in neural tissue it can gradually degrade synaptic connections.

The loss of such connections is thought to contribute to mood disorders.

Good evidence supports this theory.

When psychiatrists have evaluated populations of patients who have chronic inflammatory diseases like lupus and rheumatoid arthritis, they’ve found that “all of them have higher-than-average rates of depression,” said Charles Nemeroff, a neuropsychiatrist at the University of Texas, Austin.

Of course, knowing that they have an incurable, degenerative condition may contribute to a patient’s depressed feelings, but the researchers suspect that the inflammation itself is also a factor.

Medical researchers have found that inducing inflammation in certain patients can trigger depression.

Interferon alpha, which is sometimes used to treat chronic hepatitis C and other conditions, causes a major inflammatory response throughout the body by flooding the immune system with proteins known as cytokines — molecules that facilitate reactions ranging from mild swelling to septic shock.

The sudden influx of inflammatory cytokines leads to appetite loss, fatigue and a slowdown in mental and physical activity — all symptoms of major depression.

Patients taking interferon often report feeling suddenly, sometimes severely, depressed.

If overlooked chronic inflammation is causing many people’s depression, researchers still need to determine the source of that inflammation.

Autoimmune disorders, bacterial infections, high stress and certain viruses, including the virus that causes Covid-19, can all induce persistent inflammatory responses.

Viral inflammation can extend directly to tissues in the brain. Devising an effective anti-inflammatory treatment for depression may depend on knowing which of these causes is at work.

It’s also unclear whether simply treating inflammation could be enough to alleviate depression.

Clinicians are still trying to parse whether depression causes inflammation or inflammation leads to depression. “It’s a sort of chicken-and-egg phenomenon,” Nemeroff said.

Increasingly, some scientists are pushing to reframe “depression” as an umbrella term for a suite of related conditions, much as oncologists now think of “cancer” as referring to a legion of distinct but similar malignancies.

"And just as each cancer needs to be prevented or treated in ways relevant to its origin, treatments for depression may need to be tailored to the individual."

[hookedonyonics]

you know how indulgent, wallowing mental health messaging ("I can't just yoga my depression away") has thankfully shifted to an understanding that diet, exercise, fresh air, socializing, and productivity will lift your mood and help alleviate and manage other symptoms?

i feel like there is a strong indulgent, wallowing message right now re: personal finance... like yeah okay the avocado toast vs buying a house thing is stupid but like. you do actually have to try. some of this is in your power. you just don't want to have to face that a lot of this problem is in your control and if you made some sacrifices you could get some relief and make some progress.

[anamericangirl]

I remember seeing someone say that the only questions you should be able to ask in order to correctly identify real gender dysphoria is to ask “do you feel like your life/sense of self is in poor quality” and “do you think any of those would improve if you were the opposite sex”.

Combined with the questions I’ve seen in another ask about asking why people don’t feel like they were the sex they were born as + why you don’t feel masculine/feminine enough and who said so, I feel like there would be a lot less misdiagnoses of gender dysphoria and less “trans children”.

I’ve also wanted to ask, why do you think that there isn’t any medication for true gender dysphoria yet (besides money)? One of the things I’ve read actually made me think that, if it’s classified as a mental illness, then why isn’t there any research for creating a medication for it (like bipolar depression, ADHD, etc.)?

I feel like maybe those are the only types of questions being asked considering the amount of people identifying as trans now. It's a shame because since the treatment for gender dysphoria is so drastic and life altering it's really dangerous to have such vague qualifiers for determining if someone is actually experiencing it.

About a month or so ago I responded to someone else who was also asking why I think there might not be medications for it or more attempts to create one so I'll just repeat what I said then. There’s a lot of reasons I think could contribute to that. First, mental illnesses are hard to treat and often a medication doesn’t do much other than alleviate symptoms. Therapy is probably the best option for any type of dysphoria in my opinion because dysphoria can go away and most of the time does if you actually seek therapy and treatment rather than “affirmation.” I’ve seen studies done on detransitioners and the main reason given as to why they detransitioned was they realized their dysphoria was related to “other issues” which is something people typically find out in therapy. Another reason I think there’s not much headway in a medication for gender dysphoria is financial incentive. Medical and gender affirming institutions get a big check for every one child who transitions and they’re more interested in making money than anything else. It’s not healthcare at this point. It’s just activism.