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sy-on-boy · 1 year ago

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(Potentially) new information from the Spy x Family exhibit book!

Okay, I’ve done some digging around and not gonna lie, some information in there has me excited. I can’t read Japanese so I took photos and put them through translate, so it’s not the most accurate, and please take this post with a grain of salt. Here we go!

Translations are more than welcome! Feel free to use these photos and feel free to DM me for clearer photos. I would also love to know what this all means haha. Japanese “raw” text is taken from Google translate and may be inaccurate to what is actually shown in the photos.

✩ The SxF world apparently has no Christmas!

I’ve heard claims of it, and here’s a picture I took.

“遠藤達哉先生コメント

こちらは冬の休載イラストです。電飾一個一個を北斗神拳ばりに連打して描きました。クリスマスっぽい雰囲気を出していますが、『SPY×FAMILY』の世界にクリスマスはありません。”

Google translate tells me that there’s no Christmas in the SxF world but he tried to create a Christmas-like atmosphere? Not sure but it would align with other people’s claims.

✩ Yuri apparently had a girlfriend in a rough draft!

This is Endo’s handwriting so the machine can’t recognise the words easily, but I think the woman in the bottom of Yuri’s sheet is his “girlfriend”? And Google translate tells me she’s Yuri’s “weakness” and Twilight might use her against Yuri / take advantage of the girlfriend? This is a very interesting idea that didn’t get used in canon (yet?). I think in canon, Yuri is popular but he’s too devoted to his sister. A new significant other of a prominent character would shake things up. Especially when it comes to Yuri, a member of the SSS.

By the way, Yuri’s potential designs are kind of cool. I like the ponytail.

✩ Apparently “Oscar” was one of Twilight’s potential names! + Early Twilight designs

I think we know Yor was originally short for Yorlanda (this is in the upper sheet). There’s a whole list of names beside Twilight and the name Oscar オスカー appeared frequently. There are also more names that I can’t decipher.

✩ Designs of some potential WISE agents! (And early Fiona)

Fiona’s sheet (next to Yuri’s) was titled “WISE spy (female)” and now we have a sheet titled “WISE spy (male)”. Was Fiona a placeholder spy that made it to the main cast? Or will this “male spy” end up having significance too? The two smaller heads at the left are apparently Twilight’s associates. Also, a Melinda sketch. Not gonna lie, the male spy feels kinda cute. Hope he’s not completely scrapped.

✩ Endo’s interview!

I feel like I should put this earlier but I was distracted with the Christmas / Yuri’s potential girlfriend thing. This is at the very end of the book. Apparently Endo was influenced by the invasion of Ukraine in 2022. This interview was apparently taken in March 2023. I think it’s fairly important so I’ll wait for a proper translation before saying anything else.

✩ Comments on Donovan, Melinda, Redacted, and Sylvia!

These two pages are together and I found it significant because Endo discusses the SxF themes. (My notes are not direct translations.) Apparently:

Sylvia’s scene in Mission 20 is Endo’s favourite scene, and he was looking at materials related to war for a long time and wondered if he could make use of it. [JP below]

とてもお気に入りのシーンです。「SPY×FAMILY」の連載とは関係無し昔から戦争に関する資料は色々見ていたので、多少はこの作品にも活かせているのかなーと。

Donovan’s statement of “in the end, people will never understand each other” (rough paraphrase) is the theme of the work. And Endo wanted to create a feeling of Donovan being the final boss. He didn’t plan on arranging it from the beginning, but he thinks the Desmonds are a good contrast to the Forgers. (Does this mean the Forgers think people will understand each other?) [JP below]

作品のテーマでもあるセリフですね。少しでもドノバンのラスボス感を醸し出せればいいなーと思いながら描きました。最初から意図して配置したわけではないですが、デスモンド家はフォージャーと良い対比になっているのかなと思います

The chapters on Twilight’s past coincided with the anime so Endo thought it was a good idea to explore Twilight’s past. [JP below]

アニメが始まるタイミングなのもあって、黄昏〉という人物を掘り下げる良い機会かなと思い過去編を入れました。あまり重たくなりすぎないように、でも伝えたいことは最低限伝えられるように、自分なりにバランスを取って描いたつもりです。

Melinda is described as “friendly” (?) even though she is dignified. A positive description of Melinda… interesting. What’s also interesting is that after she learns that Yor is the mother of the child who got into a fight with Damian, she “shows interest”. Melinda, what do you want with Anya? [JP below]

ダミアンの母で、東国元首相夫人。気品に溢れつつも、気さくな性格。ヨルが息子と喧嘩したアーニャの母親と知り、興味を示している。

I personally think these two pages contain hints about the mystery of the featured characters and would love to know what it means :D

✩ Early Yor and Bond!

There’s a lot more Yor but again the image limit is constricting me. I really like the Bond designs, they’re funny and he’s just a chonky little boi :)

✩ Comments on the panel of Twilight’s head in Yor’s lap!

“��しいイチャイチャ��ーンです。ヨルさんは一年中酔っ払ってればいいのに”

Which apparently means: “a rare flirting (?) scene, I wish Yor was drunk all year long”

?!??! Twiyor?!! Hello!! I cannot resist mentioning this one, this is one of my favourite Twiyor / SxF scenes. Are we gonna get more drunk Yor? More Twiyor? More flirting? I’m excited now.

I’ve reached the image limit, so here’s all for this post for now! Translations are totally welcome and again I would love to know what this all means. I’m sorry if I accidentally said misleading information, so please tell me so I can correct it. Once again, don’t take my words as complete fact. The Yuri girlfriend thing is really surprising to me haha.

#spy x family #spy x family exhibition #yor forger #loid forger #yuri briar #fiona frost #bond forger #donovan desmond #sylvia sherwood #melinda desmond #twiyor #i guess. that comment seems shippy to me #long post

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covid-safer-hotties · 2 months ago

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Also preserved on our archive (Daily updates!)

By Stephani Sutherland

Gentle nasal spray vaccines against COVID, the flu and RSV are coming. They may work better than shots in the arm

Alyson Velasquez hates needles. She never liked getting shots as a kid, and her anxiety only grew as she got older. “It really ballooned in my teens and early 20s,” she says. “It became a full-blown phobia.” She would panic at the sight of a needle being brought into an exam room; more than once she passed out. Velasquez says that she took an antianxiety medication before one appointment yet still ran around the room screaming inconsolably “like I was a small child; I was 22.” After that episode Velasquez, now a 34-year-old financial planner in southern California, quit needles completely. “No vaccinations, no bloodwork. For all of my 20s it was a no-go for me,” she says.

Then COVID showed up. “It finally hit a point where it wasn’t just about me,” Velasquez says. “It felt so selfish not to do this for the greater public health and the safety of our global community.” So she got vaccinated against the SARS-CoV-2 virus in 2021, although she had to sit on her husband’s lap while he held her arms. “It was a spectacle. The poor guy at CVS ... he did ask me, ‘Are you sure you want to do this?’” She very much did. “I’m very pro-vaccine. I am a rational human. I understand the necessity of [getting] them,” she insists. But today she still struggles with each injection.

Those struggles would end, however, if all her future vaccinations could be delivered by a nasal spray. “Oh, my God, amazing!” Velasquez says.

The amazing appears to be well on its way. Vaccines delivered through the nose are now being tested for several diseases. In the U.S., early clinical trials are showing success. Two of these vaccines have generated multiple immune system responses against the COVID-causing virus in people who received them through a puff up the nose; earlier this year their makers received nearly $20 million from Project NextGen, the Biden-Harris administration’s COVID medical initiative. Researchers are optimistic that a nasal spray delivering a COVID vaccine could be ready for the U.S. as soon as 2027. Although recent efforts have focused on inoculations against SARS-CoV-2, nasal vaccines could also protect us against the flu, respiratory syncytial virus (RSV), and more.

A few nasal vaccines have been introduced in the past, but they’ve been beset by problems. The flu inoculation FluMist has not gained popularity because of debates about its effectiveness, and a different vaccine was pulled from the market decades ago because some people had serious side effects. In China and India, nasal vaccines for COVID have been approved because those countries prioritized their development during the pandemic, whereas the U.S. and other wealthy nations opted to stick with arm injections. But this new crop of vaccines takes advantage of technology that produces stronger immune responses and is safer than preparations used in the past.

In fact, immunologists say these spritzes up the nose—or inhaled puffs through the mouth—can provide faster, stronger protection against respiratory viruses than a shot in the arm. That is because the new vaccines activate a branch of the immune system that has evolved for robust, rapid responses against airborne germs. “It may be more likely to really prevent infection from getting established,” says Fiona Smaill, an infectious disease researcher at McMaster University in Ontario. Such inoculations may also help reduce the enormous inequities in vaccine access revealed by the pandemic. These formulations should be cheaper and easier to transport to poor regions than current shots.

But nasal vaccines still face technical hurdles, such as how best to deliver them into the body. And unlike injected vaccines, which scientists can measure immune responses to with blood tests alone, testing for immunity that starts in nose cells is more challenging. But researchers working in this field agree that despite the hurdles, nasal formulations are the next step in vaccine evolution.

Traditional vaccines injected through the skin and into an arm muscle provide excellent protection against viruses. They coax immune cells into making widely circulated antibodies—special proteins that recognize specific structural features on viruses or other invading pathogens, glom on to them and mark them for destruction. Other immune cells retain a “memory” of that pathogen for future encounters.

Intramuscular injection vaccines are good at preventing a disease from spreading, but they do not stop the initial infection. A nasal spray does a much better job. That’s because sprays are aimed directly at the spot where many viruses first enter the body: the nose and the tissue that lines it, called the mucosa.

Mucosa makes up much of our bodies’ internal surfaces, stretching from the nose, mouth and throat down the respiratory tract to the lungs, through the gastrointestinal tract to the anus, and into the urogenital tract. Mucosa is where our bodies encounter the vast majority of pathogenic threats, Smaill says, be it flu, COVID, or bacterial infections that attack the gut. This tough, triple-layered tissue is specialized to fight off invaders with its thick coating of secretory goo—mucus—and with a cadre of resident immune cells waiting to attack. “Mucosa is really the first line of defense against any infection we’re exposed to,” Smaill says.

Mucosal immunity not only prepares the immune system for the fight where it occurs but also offers three different types of protection—at least one more than a shot does. Nasal vaccines and shots both mobilize immune messenger cells, which gather the interlopers’ proteins and display them on their surfaces. These cells head to the lymph nodes, where they show off their captured prize to B and T cells, which are members of another part of the immune system called the adaptive arm. B cells, in turn, produce antibodies, molecules that home in on the foreign proteins and flag their owners—the invading microbes—for destruction. Killer T cells directly attack infected cells, eliminating them and the microbes inside. This provides broad protection, but it takes time, during which the virus continues to replicate and spread.

That’s why a second type of protection, offered only by the mucosal tissue, is so important. The mucosa holds cells of the innate immune system, which are the body’s “first responders.” Some of these cells, called macrophages, recognize invasive microbes as foreign and swallow them up. They also trigger inflammation—an alarm sounded to recruit more immune cells.

Another part of this localized response is called tissue-resident immunity. These cells don’t have to detect telltale signs of a pathogen and make a long journey to the infected tissue. They are more like a Special Forces unit dropped behind enemy lines where a skirmish is occurring rather than waiting for the proverbial cavalry to arrive. This localized reaction can be quite potent. Its activation is notoriously difficult to demonstrate, however, so historically it’s been hard for vaccine makers to show they’ve hit the mark. But it turns out that one type of antibody, called IgA, is a good indicator of mucosal immunity because IgAs tend to predominate in the mucosa rather than other parts of the body. In an early trial of CoviLiv, a nasal COVID vaccine produced by Codagenix, about half of participants had detectable IgA responses within several weeks after receiving two doses. That trial also showed the vaccine was safe and led to NextGen funding for a larger trial of the vaccine’s efficacy.

It’s possible an inhaled vaccine may provide yet one more layer of protection, called trained innate immunity. This reaction is a bit of a mystery: although immunologists know it exists and appears also to be produced by intramuscular injections, they can’t quite explain how it works. Immune cells associated with trained innate immunity seem to have memorylike responses, reacting quickly against subsequent infections. They also have been found to respond against pathogens entirely unrelated to the intended vaccine target. Smaill and her colleagues found that when they immunized mice with an inhaled tuberculosis vaccine and then challenged them with pneumococcal bacteria, the mice were protected. In children, there is some evidence that a tuberculosis vaccine, in the arm, generates this type of broad response against other diseases.

Akiko Iwasaki, an immunologist at Yale University who is working to develop a nasal vaccination for COVID, sees two major potential benefits to nasal immunity in addition to better, faster, more localized protection. First, attacking the virus in the nose could prevent the disease from being transmitted to others by reducing the amount of virus that people breathe out. And second, Iwasaki says, the spray may limit how deeply the infection moves into the body, so “we believe that it will also prevent long COVID.” That debilitating postinfection condition, sometimes marked by signs of entrenched viral particles, disables people with extreme fatigue, chronic pain, a variety of cognitive difficulties, and other symptoms.

Making a new vaccine is hard, regardless of how you administer it. It needs to raise an immune response that’s strong enough to protect against future invasions but not so strong that the components of that response—such as inflammation and fever—harm the host.

The lining of the nose puts up its own barriers—literal, physical ones. Because the nasal mucosa is exposed to so many irritants from the air, ranging from pet hair to pollen, the nose has multiple lines of defense against invading pathogens. Nostril hair, mucus, and features called cilia that sweep the nasal surface all aim to trap small foreign objects before they can get deeper into the body—and that includes tiny droplets of vaccine.

And lots of small foreign particles—often harmless—still make it through those defenses. So the nose has developed a way to become less reactive to harmless objects. This dampened reactivity is called immunological tolerance, and it may be the biggest hurdle to successful development of a nasal vaccine. When foreign particles show up in the bloodstream, a space that is ostensibly sterile, immune cells immediately recognize them as invaders. But mucosal surfaces are constantly bombarded by both pathogens and harmless materials. The immune system uses tolerance—a complex series of decisions carried out by specialized cells—to determine whether a substance is harmful. “This is very important because we can’t have our lungs or gastrointestinal tract always responding to nonharmful foreign entities that they encounter,” says Yale infectious disease researcher Benjamin Goldman-Israelow. For example, inflammation in the lungs would make it hard to breathe; in the gut, it would prevent the absorption of water and nutrients.

These barriers may hamper the effectiveness of a nasal flu vaccine that’s been around for a while, called FluMist in the U.S. and Fluenz in Europe. The inoculation is safe, says infectious disease scientist Michael Diamond of Washington University in St. Louis, but it faces a similar problem as do injected flu vaccines: it isn’t very effective at warding off new seasonal flu strains. This might be because flu strains are so common, and people are frequently infected by the time they are adults. Their immune systems are already primed to recognize and destroy familiar flu particles. FluMist is built from a live flu virus, so immune cells probably treat the vaccine as an invader and demolish it as soon as it shows up in the nose, before it has a chance to do any good. This preexisting immunity isn’t such an issue in children, who are less likely to have had multiple flu infections. Nasal flu vaccines are routinely used to inoculate kids in Europe.

In other vaccines, researchers often use adjuvants, special agents that attract the attention of immune cells, to boost a response. Some nasal vaccines use adjuvants to overcome tolerance, but in the nose, adjuvants can pose unique dangers. In at least one case, a nasal adjuvant led to disastrous consequences. An intranasal vaccine for influenza, licensed in Switzerland for the 2000–2001 season, used a toxin isolated from Escherichia coli bacteria as an adjuvant to provoke a reaction to the inactivated virus. No serious side effects were reported during the trial period, but once the vaccine was released, Swiss officials saw a concerning uptick in cases of Bell’s palsy, a disease that causes weakness or paralysis of the facial muscles, often leading to a drooping or disfigured face. Researchers at the University of Zurich estimated that the adjuvanted flu vaccine had increased the risk of contracting Bell’s palsy by about 20 times, and the vaccine was discontinued. “We need to be cautious about using adjuvants like that from known pathogens,” says pharmaceutical formulations scientist Vicky Kett of Queen’s University Belfast in Northern Ireland.

To get around the challenges posed by the nose, some researchers are exploring vaccines inhaled through the mouth. Smaill is working on one of them. She and her McMaster colleagues aerosolized their vaccine for COVID into a fine mist delivered by a nebulizer, from which it rapidly reaches the lungs. Experiments in mice have shown promising results, with mucosal immunity established after administration of the vaccine.

Another vaccine strategy is to use a harmless virus to carry viral genes or proteins. Researchers at the Icahn School of Medicine at Mount Sinai in New York City selected a bird pathogen, Newcastle disease virus (NDV). “It’s naturally a respiratory pathogen,” so it infects nasal cells, says Michael Egan, CEO and chief scientific officer of CastleVax, a company that formed to develop the NDV vaccine for COVID. A small early clinical trial showed the CastleVax vaccine was safe and caused robust immune responses in people. “Those results were very promising,” Egan says. People who received the vaccine also produced antibodies that indicated multitiered mucosal immunity, not simply the adaptive immunity from a shot in the arm.

Following that trial, the CastleVax project received NextGen funding, and results from a trial of 10,000 people are expected in 2026. Half of those people will receive a messenger RNA (mRNA) injection, and half will get the new NDV nasal spray. The data should show whether the new nasal vaccine can do a better job of preventing infection than the mRNA injections. Egan has high hopes. “We’re expecting to see a lot fewer breakthrough infections in people who got the vaccine up the nose by virtue of having those mucosal immune responses,” he says.

Florian Krammer, one of the Mount Sinai researchers behind the vaccine, engineered NDV particles to display a stabilized version of the spike protein that’s so prominent in SARS-CoV-2. “You end up with a particle that’s covered with spike,” he says. Spike protein in the bloodstream can raise an immune response. But the NDV vaccine works in another way, too. The virus particle can also get into cells, where it can replicate enough times to cause virus particles to emerge from the cells, provoking another immune reaction. Before moving into human trials, however, researchers had to complete clinical trials to establish that the Newcastle virus is truly harmless because the nose is close to the central nervous system—it has neurons that connect to the olfactory bulb, which is part of the brain. Those trials confirmed that it is safe for this use.

Nasal sprays aim directly at the spot where most viruses first enter the body: the nose. This type of caution is one reason a COVID nasal vaccine approved in India hasn’t been adopted by the U.S. or other countries. The inoculation, called iNCOVACC, uses a harmless simian adenovirus to carry the spike protein into the airway. The research originated in the laboratories of Diamond and some of his colleagues at Washington University at the start of the pandemic, when they tested the formulation on rodents and nonhuman primates. “The preclinical data were outstanding,” Diamond says. Around the time he and his colleagues published initial animal results in Cell in 2020, Bharat Biotech in India licensed the idea from the university. In a 2023 phase 3 clinical trial in India, the nasal vaccine produced superior systemic immunity compared with a shot.

Diamond says American drug companies didn’t pursue this approach, because “they wanted to use known quantities,” such as the mRNA vaccines, which were already proving themselves in clinical trials in 2020. As the pandemic took hold, there was little appetite to develop nasal vaccine technology to stimulate mucosal immunity while the tried-and-true route of shots in the arm was available and working. But now, four years later, an inhaled vaccine using technology similar to iNCOVACC’s is being developed for approval in the U.S. by biotech company Ocugen. Both inhaled and nasal forms of the vaccine are set to undergo clinical trials as part of Project NextGen. These new vaccines are using classical vaccine methods based on the virus rather than using new, mRNA-based technology. The mRNA preparations were developed specifically for intramuscular injections and would have to be significantly modified.

Codagenix, which is developing CoviLiv, sidestepped the need for a new viral vector or an adjuvant by disabling a live SARS-CoV-2 virus. To make it safe, scientists engineered a version of the virus with 283 mutations, alterations to its genetic code that make it hard for the virus to replicate and harm the body. Without all these genetic changes, there would be a chance the virus could revert to a dangerous, pathogenic form. But with hundreds of key mutations, “statistically, it’s basically impossible that this will revert back to a live virus in the population,” says Johanna Kaufmann, who helped to develop the vaccine before leaving Codagenix for another company earlier this year.

Because most people on the planet have now been exposed to SARS-CoV-2—in the same way they’re regularly exposed to the flu—some nasal vaccines are being designed as boosters for a preexisting immune response that is starting to wane. For example, Yale researchers Iwasaki and Goldman-Israelow are pursuing a strategy in animals deemed “prime and spike.”

The idea is to start with a vaccine injection—the “prime” that stimulates adaptive immunity—then follow it a few weeks later with a nasal puff that “spikes” the system with more viral protein, leading to mucosal immunity. In a study published in 2022 in Science, Iwasaki and her colleagues reported that they primed rodents with the mRNA vaccine developed by Pfizer and BioNTech, the same shot so many of us have received. Two weeks later some of the mice received an intranasal puff of saline containing a fragment of the SARS-CoV-2 spike protein. Because the animals had some preexisting immunity from the shot, the researchers didn’t add any adjuvants to heighten the effects of the nasal puff. Two weeks later researchers detected stronger signs of mucosal immunity in mice that had received this treatment compared with mice that got only the shot.

“Not only can we establish tissue-resident memory T cells” to fight off the virus in the nose, Iwasaki says, but the prime-and-spike method also produces those vigorous IgA antibodies in the mucosal layer. “And that’s much more advantageous because we can prevent the virus from ever infecting the host,” she notes. The study suggests that this approach might also lessen the chances of transmitting the disease to others because of the lower overall viral load. Experiments in hamsters demonstrated that vaccinated animals shed less virus, and they were less likely to contract COVID from infected cage mates that had not been vaccinated themselves.

Although most of the new vaccine strategies are aimed at COVID, nasal vaccines for other diseases are already being planned. Kaufmann, formerly of Codagenix, says the company currently has clinical trials underway for nasal vaccines against flu and RSV. CastleVax’s Egan says “we have plans to address other pathogens” such as RSV and human metapneumovirus, another leading cause of respiratory disease in kids.

Vaccines that don’t need to be injected could clear many barriers to vaccine access worldwide. “We saw with COVID there was no vaccine equity,” Smaill says. Many people in low-income countries never received a shot; they are still going without one four years after the vaccines debuted.

In part, this inequity is a consequence of the high cost of delivering a vaccine that needs to stay frozen on a long journey from manufacturing facilities in wealthy countries. Some of the nasal sprays in development don’t need deep-cold storage, so they might be easier to store and transport. And a nasal spray or an inhaled puff would be much easier to administer than a shot. No health professional is required, so people could spray it into their noses or mouths at home.

For these reasons, needle-free delivery matters to the World Health Organization. The WHO is using the Codagenix nasal spray in its Solidarity Trial Vaccines program to improve vaccine equity. The CoviLiv spray is now in phase 3 clinical trials around the world as part of this effort. “The fact that the WHO was still interested in a primary vaccination trial in the geographies it’s passionate about—that’s indicative that there is still a gap,” Kaufmann says. CoviLiv was co-developed with the Serum Institute of India, the world’s largest maker of vaccines by dose. The partnership enabled production at the high volume required for Solidarity.

The CastleVax vaccine with the NDV vector provides another layer of equity because the facilities required to make it already exist in many low- and middle-income countries. “The cool thing is that NDV is a chicken virus, so it grows very well in embryonated eggs—that’s exactly the system used for making flu vaccines,” Krammer says. For example, for a clinical trial in Thailand, “we just shipped them the seed virus, and then they produced the vaccine and ran the clinical trials,” he says. Many countries around the world have similar facilities, so they will not need to depend on pharma companies based in richer places.

Even high-income countries face barriers to vaccination, although they may be more personal than systemic. For very many people, the needle itself is the problem. Extreme phobia such as Velasquez’s is uncommon, but many people have a general fear of needles that makes vaccinations stressful or even impossible for them. For about one in 10 people needle-related fear or pain is a barrier to vaccinations, says C. Meghan McMurtry, a psychologist at the University of Guelph in Ontario. Needle fear “is present in most young kids and in about half of adolescents. And 20 to 30 percent of adults have some level of fear.” A review of studies of children showed that “concern around pain and needle fear are barriers to vaccination in about 8 percent of the general population and about 18 percent in the vaccine-hesitant population,” McMurtry adds.

Some people are wary of injected vaccines even if they’re not afraid of needles, Kett says; they see injections as too invasive even if the needle doesn’t bother them. “We’re hopeful that something administered by the nasal route would be less likely to come across some of those issues,” Kett says.

In the U.S., however, sprays and puffs won’t be available until they are approved by the Food and Drug Administration, which requires clear evidence of disease protection. As Diamond points out, standards for such evidence are well established for injections, and vaccine makers can follow the rule book: regulations point to particular antibodies and specific ways to measure them with a simple blood test. But for nasal vaccines, Iwasaki says, “we don’t have a standard way to collect nasal mucus or measure antibody titers. All these practical issues have not been worked out.”

Iwasaki is also frustrated with a restriction by the U.S. Centers for Disease Control and Prevention that stops researchers from using existing COVID vaccines in basic research to develop new nasal sprays. The rule is a holdover from 2020, when COVID injections had just been developed and were in short supply; people had to wait to get vaccinated until they were eligible based on factors such as age and preexisting conditions. “That made sense back then, but those concerns are years old; things are different now,” Iwasaki says. “Now we have excess vaccine being thrown out, and we cannot even get access to the waste, the expired vaccine.”

Today scientists want to contrast the effectiveness of nasal formulations with injections already in use. “Those comparisons are really important for convincing the FDA that this is a worthy vaccine to pursue,” Iwasaki says. But the restriction has held up studies by her company, Xanadu, slowing down work. (The CDC did not respond to a request for comment.)

Despite the bureaucratic and scientific hurdles, the sheer number of nasal vaccines now in clinical trials encourages Iwasaki and other scientists pursuing the needle-free route. They say it seems like only a matter of time before getting vaccinated will be as simple as a spritz up the nose.

Velasquez, for one, can’t wait for that day to arrive. The circumstances that finally forced her to reckon with her fear of needles (a global pandemic, the prospect of parenthood and the numerous blood tests that accompanied her pregnancy) were so much bigger than her. If not for them, she might still be avoiding shots. “So having vaccines without needles—I would get every vaccine any doctor wanted me to get, ever. It would be a complete game changer for me.”

#vaccination #mask up #covid #pandemic #public health #wear a mask #covid 19 #wear a respirator #still coviding #coronavirus #sars cov 2 #get vaccinated #vaccinate your kids

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gallaghersgal · 5 months ago

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“you’re naked aren’t you” with fiona please i need to see what you'll do with fiona -🐁

ugh i love fiona, tysm for requesting <33 18+. mature but not fully nsfw, nudity and kissing

you step into fiona's room in her robe, a sweet smile painted on your lips. "fi," you say to get her attention, huffing when she doesn't look up from the papers scattered across her bed. "fiiiii. fiona," you press again.

"jesus, what!?" she responds with a playful smile, finally looking up to meet your eyes. her gaze doesn't stay there for long though, eyes raking over your form, hidden by the fluffy robe but with just enough skin on display to grab her attention. "you're naked under there, aren't you," she teases.

"maybe," you tease back, stepping over to the bed and putting a hand on her thigh. you rub your thumb across the soft skin of her inner thigh, knowing how much the action gets to her. "c'mon, pack it up for the night. spend some quality time with your girlfriend, who you've so rudely been ignoring."

suddenly she grabs you by the waist, yanking you down into her lap and drawing an excited giggle from your lips. nimble fingers pull at the strip of fabric holding the robe closed while she seals her mouth to yours, taking advantage of your soft gasp to slip her tongue past your lips.

"you're insatiable, you know that?" she mumbles against your lips, her hands trailing over the expanse of your now bare skin. "just help me clean up these papers, can't leave my girl needy."

let's have a sleepover at mine <3 | inbox

#maggie’s musings [blurbs]#fiona gallagher x reader #fiona gallagher imagine #❀ fiona gallagher #🦺 sleepover #if u give a mouse a tumblr [mouse]

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rachetmath · 1 year ago

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Jaune the Strategist

Jaune: Um… General Ironwood? I have a question.

Ironwood: What is it Mr. Arc?

Jaune: Why not release the video footage of Tyrian killing a bunch of people?

Clover: Are you crazy? If we release such a video it cause panic in Mantle.

Jaune: I hear you. But... isn’t the Atlas military already being framed for countless murders?

Ironwood: Yes.

Jaune: And no one in Mantle is willing to follow protocol because they don’t trust us right?

Ironwood: Well... yes.

Jaune: Okay. So why not use this to our advantage?

Ruby: Explain.

Jaune: I mean come on. Seriously? We have proof. We have video display. And if this has been happening for a while then we have dead bodies that can hold our case.

Ironwood: Mr. Arc, I’m going to need you to further elaboration.

Jaune: What’s there to- Look, Tyrian has been killing people for a while, right?

Qrow: Yeah.

Jaune: We have video proof that he committed the massacre at Robin’s party. We could just report this and clear Penny’s name.

Ironwood: That is true.

Jaune: Plus with the few bodies Tyrian left behind, which I’m hoping your Atlas soldiers investigated completely. Like the time and location of death. As well as how they died. Basically if Tyrian left multiple victims, can’t we compare them to the other corpses from the party.

Ironwood: Huh.

Jaune: Not only that but Tyrian has a poisonous tail. Didn’t some of them have a hint poison consumed or at least small pick to their bodies.

Ironwood: Oh. That is something to consider.

Clover: Okay, but still doesn’t change the fact if we tell the people a killer is on the loose it will cause panic.

Jaune: True. But it could also make people listen. Think about it, they’re already being invaded by grimm everyday. And now they have killer amongest them. Wouldn’t that force them to reconsider they’re options?

Clover: … My… My Oum he could right.

Marrow: Okay but what about Robyn?

Jaune: Mantle’s Champion? Happy Huntresses? Are you serious? Do you honestly think she would not make a killer her top priority?

Marrow: Huh.

Jaune: I’m just saying, why are we keeping this under raps and quickly turning to Martial law?

Ironwood: Wow… anything else Mr.Arc

Jaune: Why frame Penny?

Ruby: She’s the Protector of Mantle.

Jaune: She also a robot. With a human soul. Who recorded everything! Who so far never got hacked? So why her specifically? If anything I would have got Penny out the way and framed one of the Ace-ops. Specifically Marrow. Hell why not frame Robyn herself?

Marrow: Whoa why me?

Jaune: You know why.

Blake: But tell us why.

Ironwood: Damn he’s right. That absolutely makes sense considering he’s a Faunus and recent member of the Ace ops.

Jaune: Exactly.

Blake: Are you two serious?!

Jaune: Blake think about how much conflict that would cause. A faunus in the Atlas military. An Ace operative killed and injured a bunch of innocent people. Humans and faunuses mind you. Not only would that cause division amongest the people of Mantle but the school and the soldiers.

Ironwood: He’s right. We have faunases who attend this school and are apart our units.

Jaune: It’ll be chaos. Racism and Hatred in the air. And with that much negativity the grimm attacks would be sky rocketing to the masses. Screw trying to get Amity Arena up we might as well have focused our time on containment. Hell that would been a better reason to initiate Martial law. Something I think Robyn would agree to. Considering Fiona is a faunus and her teammate.

Ironwood: So basically framing Penny was-

Jaune: A stupid idea? ABSO-FREAKEN-LUTLY!! Who ever made this plan had to be dumb as bricks.

Watts: *sneezes*

Jaune: I’m mean now I might as well ask this question. Has anyone ever disagreed with Penny’s creation?

Ironwood: I mean-… ... actually... yes we had a few people who disagreed.

Jaune: Also if you have a file for Tyrian, then what about Cinder, Emerald, Mercury or Hazel?

Ironwood: Why yes we---- Hold up. You all saw Hazel?

Jaune: Yeah.

Ironwood: And you survived?

Nora: Yes. Though with our tails between our legs. How do you know him?

Ironwood: How do you think I lost half of my body?

Jaune: Damn. And I thought Ren and Qrow had it worse. How powerful is he?

Ironwood: He crippled Ozpin.

Oscar: (And he said he stood a chance. He could’ve killed us both.)

Jaune: (We’ll most definitely need to jump him.) An-anyways, back on topic. So, who out all the other people were against the Penny project? Simply put who hates Pietro the most?

Ironwood: Well… there was Professor Watts.

Jaune: Professor Watts?

Ironwood: He was an inventor as well. He was even to soul creator of the Atlas robots you’re associated with. However he died in accident.

Jaune: How long ago?

Ironwood: Months ago?

Jaune: Okay now that’s weird.

Weiss: So what Jaune? He died.

Winter: Yes but I understand why Mr.Arc is suspicious. In Cinder’s file, after committing four first degree murders she disappeared.

Jaune: Then she suddenly appears back at Beacon with a way to hack the military.

Clover: Tyrian was captured but then escaped and he disappeared as well.

Qrow: Then he came out nowhere and tried to capture Ruby.

Ironwood: Hazel disappeared once too.

Oscar: And then I saw him on my way to Mistral.

Jaune: Is any of this making sense?

Ironwood: Yes. Clover I need you to follow up on some the victims of the previous crimes. And Winter I need you look into Watt’s case. Lets make sure he’s dead. If not we need evidence.

Winter: Yes sir.

Ironwood: Well, Mr. Arc it seem I underestimated your intelligence. I will not call in Martial law.

Jaune: No-no. Keep it in mind.

Nora: SAY WHAT?! I THOUGHT YOU WERE TRYING TO AVOID IT!!

Jaune: I am. But Robyn could still cause trouble for us down the road. We need to be ready when she could take things too far.

Nora: But-

Ironwood: It’s only if she continues to be an obstacle.

Nora: *silent*

Ironwood: Alright. Everyone back to work. Keep an eye out for Tyrian. And if you learn anything you report to me immediately.

Ace-ops: Yes sir.

Ren: Yes sir.

*JNPR Dorm Room*

Nora: Jaune, I can’t believe you sided with Ironwood.

Ren: Nora, it is a constitutions plan. It’s not going to happen.

Nora: I’m just saying the people of Mantle are already having a hard time.

Ren: I understand but-

Nora: But what? That getting Amity Arena up is more important than helping the people.

Ren: What about the world? What about all of Remnant?

Nora: How can help the world if we can’t help a country?!

Ren: We can’t always focus on the small things Nora. We need to consider the bigger picture.

Nora: So after all we’ve been through before you want to throw that away?

Ren That not what I’m saying. I-

Jaune: ENOUGH!!

Jaune: Please. Stop arguing.

Ren: Jaune, look I want to say-

Jaune: Stop. Sit. Both of you.

Nara and Ren: *sit separately from each other*

Jaune: Look, Nora, I understand. I know Mantle going through hard times. Due to the trading routes and transportation being limited, people are starting to struggle to get in and out of city. Stores and companies are closed so people are having trouble finding work. And without work, they can’t make money. And without money they can’t pay rent nor provide for their families. Basically majority of those people might as well not have homes soon.

Nora: Then you know why Martial law can’t happen. It will make things worse.

Jaune: Yes. That is why I would rather keep it as a last resort. However, with Mantle’s lack of funding and resources, I almost can’t blame Robyn for what’s she’s doing. However, two wrongs don’t make a right.

Nora: Hmm.

Ren: Well said Jaune.

Jaune: And you. Don’t think I’m openly siding with Ironwood. I only did that because I need everyone on the same page.

Ren: Jaune.

Jaune: At Beacon, Amber, Ozpin and Pyrrha died. Then the world got divide. Mistral, we almost died.

Nora: We survived.

Jaune: Through the skin of our teeth Nora! We got lucky! And Hazel, Emerald and Mercury stilled escaped!

Nora: *hates when he’s right*

Jaune: Now Tyrian is here. And even if my theory on Watts is correct, we still don’t know what they’re up to. Not to mention, we’re keeping secrets too. Especially, about Salem., who may have sent them here to retrieve the lamp. And worse, kill Oscar.

Nora and Ren: … … …

Jaune: Look… … Basically what I’m saying we need to be careful. We are no longer students. We are hunters. Every move we make could jeopardize what we are trying to accomplish. Even the people we trust could be a problem if we’re not careful.

Nora: So you don’t trust Ruby?

Jaune: Yeah. But keeping these secrets could get us in trouble, or most likely, have a gun to our heads. And Ironwood has plenty of them compared to us.

Ren: So what should we do?

Jaune: We do what we started this journey for. We search for answers.

#rwby #jaune arc #ruby rose #weiss schnee #lie ren #nora valkyrie #penny polendina #tyrian callows #james ironwood #winter schnee #clover ebi #rwby marrow #jnpr #hazel rainart #rwby watts #oscar pines #qrow branwen #blake belladonna #robyn hill

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v4vandana · 3 months ago

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The Musician Zodiac Sign=Scorpio 🦂♏️

Lana Del Rey, Scorpio Rising

I observed that almost all musicians have Scorpio placements(mostly Risings). Scorpio is the sign of transformation and rules over our genitals(sacral chakra), and sacral chakra is the chakra of sexuality and creativity. Scorpios use this to their advantage to channel their creativity(think of lanadelrey,theweeknd&jenniekim). Sexual Energy is Creative Energy.

Kali Uchis, ScorpioMoon&Rising

Melanie Martinez, Scorpio Rising

Bjork, Scorpio Sun,Moon&Rising

Unlike Cancers, Scorpios tend to have very unique voices and style. Scorpios tend to be known for their unique styles and are more unconventional than Aquarius. Aquarius are unconventional in a sense they like to oppose to whatever the society(11th house) considers acceptable, think of Audrey Hepburn(AquariusASC). However Aquarius are not interested in the arts, they are interested in changing the society, for example Princess Diana(Aquarius Moon) and Marilyn Monroe(Aquarius Moon). Tangent back to Cancers, they tend to have a gorgeous voices(arianagrande,adele,conangray). All water signs are creative and gifted with gorgeous voices. Sacral Chakra is also governed by the water element.

The Weeknd, Scorpio Moon & Cancer Rising

Lily Rose Depp, Scorpio Moon&Rising

Jennie Kim, Scorpio Moon

They all collaborated on a show together and produced a very sensual, scorpio-like song. ONE OF YOUR GIRLS

Mitski, Scorpio Rising

Marina, Scorpio Rising

Beabadoobee, Scorpio Rising

Kate Bush, Scorpio Rising

Fiona Apple, Scorpio Rising

I wouldve loved to add more examples but i use phone and the maxium is 10 pics. Also pls dont be harsh on me, its my first post. I will try to improve!!

#Scorpio #Scorpio Rising #astrology #astrology observations #astro notes #astro community #astrology placements #astrology thoughts #zodiac signs

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thelongforgottenrealm · 5 months ago

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UPDATE 07.02.24 / event #4

After a trial, anyone who was involved in the riots has been found guilty of treason: a verdict that is punishable by death. On the night before the prisoners are to be hanged they were being transported from the prisons to Lorcan where the executions were to take place.

During the trials, it was discovered that the leader of the riots was a man who lived in the villages there and Roderick wished to send a message to all of Astaira but, especially, the citizens of Lorcan and squash any feelings of rebellion that may have stirred. The prisoners were to be hanged upon the battlements atop the castle walls -- where their bodies were to stay until they rotted away. Performing the executions at Lorcan castle would also deter any acts of rebellion during the event, as Lorcan is one of the hardest fortresses to breach in the world.

During the transportation of the prisoners, a great thunderstorm hailed down upon them. Their guards sought shelter in a tavern in the village of Lorcan. The captains of the guards went inside to get warm, while a few guards keep watch over the caged prisoners.

Inside, FINN CALLEARY is gambling with the locals and entices the guards to join him, hoping to take their coin. It is his sister, FIONA CALLEARY, who has come to collect him who realizes that these guards are here to transport the prisoners and if there was ever a time to help them escape, it is now.

She tells her brother to distract them as long as possible -- even if that means loosing everything he has on him, while she risks her own safety to ride through the storm to the resistance's camp, where RONAN FROST, CILLIAN FROST, ISOLDA VANE, and KALE BRENNAN are ready to jump into action. Using the weather to their advantage, they are able to disarm the guards and take control of one of the armored wagons that is holding fifteen prisoners. Time, however, was not on their side and they were discovered before they could escape with the prisoners who were still trapped in the other barred carts.

While the guards searched the village and the surrounding forests for those who had escaped, the resistance, with the help of the two Callearys, head in the direction which no one had excepted: towards Lorcan castle, itself, where the Callearys were able to smuggle in the prisoners into the hidden fortress in the mountains below -- where they still remain to this day.

The prisoners who did not escape were hanged at dawn.

While RODERICK VARMONT puts out a search party for the missing prisoners, both FINN and FIONA must keep them safely in the mountain until they are able to smuggle them out again -- wondering if they should risk putting EABHA, AINE, and the LORCAN sisters in danger by confiding in them that they are there ...

#event #@kate AA: lmk if all of this sounds like roderick!#idk if hanging the bodies off the side of the castle is too much but!#i also feel like the callearys all know how to get into the mountains lair beneath lorcan except for cormac???? lmao

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wildflowerwoodsworld · 2 months ago

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So, I figured I should finally get around to doing a post on my four main OCs, bc they keep popping up in fics and I'd like to have a visual reference that's easily accessable.

Starting with my oldest OC and the one that's technically a canon character, my version of Finral's mother, Fiona Roulacase! I've done a Fiona character study here

Fiona is a nice person. That being said, her view of the world is very much "as long as me and mine are safe, I don't care." to save her family, this woman will burn the world.

Not only is she a Spatial mage, one of the rarest types of magic there is, she is a Roulacase and has the family ability of walking/portaling through most wards like they aren't there (this power comes with the price of never being able to use offensive Spatial magic). If she has been somewhere before, there is absolutely nothing anyone can do to stop her from returning there. This shows itself in her personality; she's cocky and her confidence borders on arrogance. She's impatient and finds listening to other people's personal problems tedious if they aren't part of her circle.

Fiona's main spell is her portal spell; Spatial Magic: Seraphim's Gate

Tondra Sturm is, in a word, ruthless. She is Fiona's best friend/girlfriend (depending on the story). I've done a Tondra character study here

She is based on the Evil Scientist/Chessmaster/smartest person in the room archetype, generally five steps ahead of everyone else and she knows it. She often forgets that people are, in fact, people and not just numbers/figures on a board because sometimes the fastest way from Point A to Point B is to just kill everyone in your way (this is generally the point where Julius steps in to stop her from committing mass murder).

She has weg from messing around with forbidden magic "just in case we need it." This woman's backup backup plans have backup plans. She's also the sort of person to put lightning booby traps after water booby traps so if you don't down you get electrocuted.

Tondra has trouble understanding other people and things like emotions. She can come off as cold and even heartless to people outside her circle but does try to listen to the advice of her friends.

Tondra's main spells are Lighting Creation Magic: Thurderer's Spear and Lightning Creation Magic: Lightning Wheel which create a spear and a shield respectively.

Lana Vaude is the least developed of my main ocs, but I love her all the same. She's Finral and Langris' little sister, a Silver Eagle and has a rival in Solid Silva (she has punched him in the face so many times). I've done a Lana character study here.

Lana Vaude as a character is fueled by spite. She's not good enough for her father, her magic is completely the wrong type for him to bother with her, and she's second in her mother's attention after Langris. Finral is definiately her favourite brother, but she and Langris are closer than it might originally appear as Lana wasn't foced into the same competition the boys were and Liliane didn't want either of her children interacting with Finral any more than necessary.

She spends a lot of her time in the Silver Eagles outpost on Raque beach because every time she is in the same room as Solid Silva, they get into a fight and Solid always loses despite A) having the attribute advantage and B) being a year older than Lana and Nozel is tired of listening to his little brother whine.

Lana's main spell is Fire Magic: Starburst which creates lots of tiny fireballs that go flying in every direction

Last, but definitely not least, we have my most recent OC; Lia Bardsley. She started out as a DnD OC (you can find her in @/thoughtfullyrainynightmare's incorrect DnD quotes) who bullied her way into the main story for my Everybody Lives au and expanded from there. I've done a Lia character study here.

Lia is, in a word, chaos. Almost constantly chattering at a speed of five hundred words a minute, this woman cannot sit still and will talk to anyone who so much as stands next to her for five seconds. She has a gift for getting people to tell her their life stories without her giving them a single bit of information about herself; this is very useful in her job as her job is literally to talk to people and catch the problems before they can become problems. This doesn't earn the Green Preying Mantises any stars, but it does mean that the area of Clover they oversee has the least issues out of anywhere in the country.

She's a prankster by nature and her favourite victim will always be Jack, even though he nearly always throws her out a window for her pranks when he's not involved in planning them (the one time he didn't throw her out the window, he threw her off the roof). That being said, Lia has about as much respect for Jack as Yami has for Julius, even if she doesn't always show it. If he tells her to do (or not do) something, then she listens.

Lia's main spell is Air Magic: Chrysalis which creates a platform or barriar made out of air in any shape she choses. She regularly uses this in her day to day life to hover in the air so she's at Jack's eye level when they're talking.

#black clover #black clover ocs #Fiona Roulacase #Tondra Sturm #Lia Bardsley #Lana Vaude #my ocs

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em-harlsnow · 2 months ago

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saw someone say (on tiktok where all bad opinions are) that frank was much better than monica as a parent because he stayed.

okay? and???

he stayed, sure. (barely, considering most of the time he was at a bar or on the street or at Sheila’s) but sure, we’ll say he stayed.

when he ‘stayed’, did he help anyone? did he look after his kids? did he contribute to the bills?

no, he didn’t.

what he did do was hand Liam over to drug dealers who he made a stupid bet with in season 1. what he did do was headbutt ian in the face in season 1. what he did do was convince Debbie to help him get monica out of a mental institution in season 2. what he did do was destroy Debbie's project for school in season 3. what he did do was hand his own kids over CPS because he was pissed they wouldn't let him in the house. what he did do was let his random friends piss in the corner of his child's room. what he did do was encourage carl to become a drug dealer. what he did do was convince carl he had cancer. what he did do was use carl's sperm to get a mentally ill person pregnant with like five kids. what he did do was leave his kids to the care of Fiona. what he did do was verbally abuse every single one of his kids. what he did do was steal money and food from his own family. what he did do was tell carl to his face that he wasn't ever going to be or do anything.

but that's just him as a father, right? and ive seen people say that frank would have wanted to be a good father, that he really tried, but he was an alcoholic so couldn't help it and/or monica made him the way he was.

first of all, monica did not make him anything. monica is a separate subject, I'll get into it some other time. but she didn't make him a bad father by leaving, there are plenty of good single parents, even though it's harder.

these are the things frank did to people who weren't his kids, proving he's just awful in general, as a whole.

he killed dottie and tried to take her money in season 3 I believe. he manipulated sheila, using her mental illness to his advantage and tried to make her relapse. he sexually assaulted monica when she explicitly said no and was heavily depressed. he fuelled his depressed wife with drugs and tried to make her seduce his own brother so that he could get his mother's inheritance money.

for the people who still justify frank, I'll give the very short list of all the decent fatherly things that he did.

he took the fall for carl's drug thing, claiming it was him who did it. he looked after Frannie okay, I guess, even though he didn't take her to school when he was meant to. he said a pathetic little thank you to Fiona before she left. well done him. he didn't rat out Ian when he went AWOL (altho he may have actually not known who Ian was). he was at Ian and mickey's wedding (although by force) and was not homophobic (well done, that makes it all better). he didn't say anything about mickey being gay.

at the end of the day, the list is pathetic. he did nothing. most of it is him literally doing nothing, like him not ratting out mickey. he probably did that to save his own skin, too, from Terry and from mickey. Ian, too.

in summation, I haven't even listed every bad thing frank has done because there are sooo many and I can't remember them all. therefore, he's a huge piece of shit and was not a better parent because he stayed. thanks for listening to my ted talk.

#tw sa mention #tw child abuse #shameless #ian gallagher #mickey milkovich #frank gallagher #monica gallagher #fiona gallagher #all the gallaghers #shameless opinions

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0yuri-chan0 · 1 year ago

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~Love less Nights~

Guys, Guys- okay okay listen hear me out! Just once! So Simon Petrikov from Fiona and cake. Listen this man might be old but he is fucking MHMMM! Delicious. So Ima make a fan fic about him. Yes, yes my followers are at my mercy. I totally get it but come on.

Paring - Simon Petrikov x F! Reader

Warnings - I'm to lazy to write them (Sorry)

Genre - NFSW

You and Simon were sitting on your front porch it was a month after Betty got infused with that creature only lord knows how that happened. Prismo a man you heard mentioned once in your life by Simon doesn't want to help get her back or can't. You didn't really push for more details. The wind blew gently when you looked at Simon, he looked hurt and devastated who wouldn't be? He had lost the love of his life a month ago. "It felt like my heart was ripped apart, My soul locked behind glass as I watched her be ripped apart from me."

Is what he had told you the night Betty was mangled with that horrible creature. The same night he walked up the very same steps you two are sitting on watching the sunset in silence. The same night he told you what had happened with tears streaming down his face, as you hugged him. Your fingers gripping the fabric of his Suit trying to get impossibly closer.

You'd never seen Simon in that state in all your years of knowing him. You'd never think you'd see that side of him the desperate side. The side that wants pity but at the same time doesn't. You think he'd rather be hated than pitted at this point. You knew he was near his breaking point. He was like a kid that got thrown into the deep end of the pool, and you weren't going to watch him sink.

You folded your hands into your lap with a small frown. It was getting cold and you knew Simon was still thinking about her, Betty. "Simon." You pause before looking up at the pink-ish orange-ish sky. "We should go inside its getting cold out." You said grabbing his hand gently. "And your freezing." It was true he was freezing, he was shaking like a leaf so to speak. You stood to your full height and walked into your house Simon following closely behind. "I could had saved her, Betty I mean." You sat down at the dinning room table Simon sitting across from you as he spoke softly. "I could had but I didn't I let her push me away and get trapped." His voice was raw you moved your hand and set it on top of his gently. Your eyes soften as you spoke in a caring voice. "She wanted to save you she cared Simon." His gaze met your only for a moment. But you could tell there was something more he wasn't telling you. You moved from your chair and sat in the one next to him.

You lifted his chin up with a soft smile, you wanted to be gentle its not like you always had hidden feelings... Right? "I'm here Simon, your okay now." Its was all friendly it wasn't like you were going to take advantage... Your train of thought stopped as he looked into your eyes. Hes so so very fragile, the look he gave you was so sadden. You couldn't help but lean down and kiss him. Both of your hands cupping his face. It's wrong you know its wrong. But it felt to good you always found him attractive in ways others didn't. You felt guilty for doing this to him.

Of course you felt guilty for kissing him who wouldn't? He lost the love of his life a month ago. Your brain stoped for a minute when he kissed back. One of his hands resting on your thigh when you pulled away. "If you allow me." You looked him in the eyes. You were sure your cheeks had turned pink by now. "I want to help you forget, even if its just for a minute." A nod was all you needed, and a nod is what you got. You stood up and grabbed his hand and led him to your bedroom. "I'll be gentle alright?" Simon felt your hands run up and down the sides of this torso. As you made your way to the bed you both took off each article of clothing.

He took a long breath and looked away from your naked form before laying on the bed. You moved and grabbed your strap and lube. "I haven't done this in... A while." Simon looked away embarrassed when he admitted that. You offered him a gentle smile which he gladly took. You placed a good amount of lube on your fingers, then entering two digits into his hole. His body jerked at the new feeling your digits scissoring him well enough to fit your strap inside of him. "Jesus! [Y-Y/n]!" He gasped as you brushed against his prostate. He was sensitive and the noises he made where adorable. You finally removed your fingers and lined up your strap to his hole. "Tell me if you want me to slow down or stop." You said sliding your silicone cock into him causing him to moan loudly. Your hand next to Simons head as you looked down at him with a low hum. You started moving your hips. Meeting his with a plat, plat, plat noise. And god was his facial expression was lewd.

After while you started to slam into him. Not enough to entirely break him but enough to make him enjoy it. His mind was unraveling by the second. All he could think of was the pleasure you were giving him. His hands clenched the sheets this didn't go unnoticed by you. It encouraged you to get deeper you picked up his leg and placed it on your shoulder so you could get a better angle. "H-Hah! I-Im going to cum!" He knew you acknowledged him when you hummed. Your hand moving to his cock stroking it at a steady speed you didn't want to overwhelmed him. Tears pricked into his eyes but oh you weren't done. You stop for a moment taking off his glasses and setting them on the nightstand. "What are you doin-!?" Before he could finish the question you flipped him over. Pushing his face into the pillow while he arched his back. You moved faster your fingers gripping and tangled into his curly hair while shoving his face down. The pillow staining with tears as he reached his climax. You rolled your hips one last time before he came.

His legs gave out on him, as he dropped to the bed you smiled satisfied laying next to him all he could mutter out from being extremely exhausted was a small 'thank you.' "Your welcome anytime Simon."

Guys its like 5:23 am and I wrote this y'know how you can't sleep if you're thinking of something. This was it I'm proud of it so.. Yeah! Request are always open unless stated otherwise. (Edit: guys so I made a part two✍ it's nothing dirty, just went into more detail about the night you comfort Simon👍)

#simon petrikov #adventure time #simon petrikov x reader #fiona and cake #simon petrikov x betty grof #Betty dies

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