#acute pharyngitis

[girls-who-cannot-take-it-anymore]

I have been contaminated by bacteria...

It hurts.

[north-peach]

When you start feeling sick, but it's thurdays so you power on and you make it. It's awful but you make it.

You expect the weekend to be mostly sick and then be fine or mostly fine on monday.

Instead, you are increasingly sick and you power through until you can't and then you go see a doctor and he calls you cute five times and viral once.

he also gives you the good drugs so you can do normal human things like breath and see and sleep and talk because while 3 days without sleep ain't a record, that's close to hallucination territory and no one likes to go there

anyways that's my week, how was y'alls?

[hemanthsworld]

Ultimate Guide to Respiratory Tract Infections: Symptoms, Diagnosis, and Evidence-Based Treatments for URTIs and LRTIs

Upper Respiratory Tract Infections (URTIs) Introduction Respiratory tract infections (RTIs) encompass a wide range of conditions affecting the upper and lower respiratory tracts. They are common ailments that cause significant global morbidity and economic loss. This comprehensive guide covers everything you need to know about RTIs, from symptoms and diagnosis to evidence-based treatments and…

[kusanagihaku]

i'm so sorry for bringing this up again but i just hit chapter 18 and jiro ??? requesting for metoclopramide??

if the metoclopramide is for any nausea it implies that the cause is gastroparesis... which tracks with what we know so far with jiro not taking food orally -> muscle atrophy -> weakened LES/stomach muscles, which allows reflux of stomach acid back up into the esophagus... so 1) jiro's pharyngeal and hyolaryngeal function is somehow maintained but he has ?LES atrophy?? which means 2) the pain related to oral feeding might not JUST be a gastro issue but also really bad esophageal dysphagia????

adding on what jiro said about "the issue starts when the food reaches my stomach", i'm more inclined to believe there's also some LES atrophy going on -> achalasia -> esophageal dysphagia... nicolas i am once again asking for an instrumental ax

which also makes me once again interested in finding out:

what rehab exercises yuri is giving jiro to not have pharyngeal dysphagia,,

what jiro's stigma is!!!! because how is it that mc feeding him (and maybe coming into physical contact with him and enhancing his stigma) allows him to circumvent his medical issues!!

if he does have gastroparesis -> reflux, is jiro going around hacking his lungs out because the reflux -> ?gastric aspiration -> lung damage? does the reflux also result in vocal edema, which is why jiro sounds so asthenic all the time?

(yuri also administering glucose i assume was to counter any dizziness from hypoglycemia since jiro doesn't eat / probably missed his iv drip bc he was out from mortkranken?)

. . . . . . .Jiro's inability to consume certain things can be thwarted by the pc hand-feeding him. If he tries to eat or drink anything his stomach rejects it so he gets all of his nutrients via IV. If the PC is holding it(or holding what it's contained in, in the case of the bottle of water they helped him drink from) he can drink it just fine. Jiro said it'd be good for him to eat some things orally so his organs don't deteriorate.

That's cute and also ridiculous lmao apparently Yuri doesn't know why it happens(and apparently Jiro's tried eating assisted before and it failed), but Nicolas said they should help him find more things he may be able to eat since the pc hand feeding him may help. . . .

[tricky-pockets]

y'know, I'm starting to think doctors don't know about the testosterone sore throat. Nobody ever mentioned it to me before I went on T.

Multiple times over the past two years, I've said "huh, my throat feels like I drank battery acid but that's the only symptom, must be a weird random virus." And multiple doctors have seen me, said "well, it's not strep or tonsillitis," shrugged, and wrote down "acute viral pharyngitis". Which to the best of my understanding just means "sudden case of inflamed throat... because of some kinda virus".

I just talked to a trans guy who's a voice teacher and he said it sucks but it's normal. I compared notes with the transmascs at choir and they said it happens to them too.

I really don't like that I've spent so much time being stressed out worrying that my chronic illness is getting worse and my immune system is getting weaker because I keep coming down with mysterious "viral infections". When it wasn't that at all, it was just my vocal cords changing shape. I shouldn't have to find that out from anecdotes.

[kawaiijohn]

yay yippieeeee acute pharyngitis wooooo

[jcsmicasereports]

Oropharyngeal primary syphilis by Dr Louis Noël in Journal of Clinical Case Reports Medical Images and Health Sciences

A 48-years-old healthy male was referred to our tertiary care center from an otorhinolaryngologist. The patient complained of odynophagia for the last 4 months, without any history of smoking nor chronic alcohol intake. A biopsy was performed and diagnosed chronic inflammation with fungal mycelia. Oral fluconazole did not bring any improvement.

Upon arrival, the examination shows some granular and erythematous pharyngeal lesions (Figure 1). A diagnostic work-up with local biopsies and serologies was done.

The PCR came back positive for Treponema pallidum (negative for herpes virus, chlamydia, and gonorrhea). Syphilis serologies were also positives (VDRL titer, 1:8; TPHA titer 20’480). The patient received one intra-muscular benzathine benzylpenicillin injection (2.4 million I.U.). The odynophagia and the lesions disappeared within 48 hours (Figure 2), without relapse for over two years.

Syphilis should be considered in every acute and chronic pharyngeal lesion, as oral sex may not be disclosed upon first medical consultation.

We declare no conflict of interest nor funding source. We obtained the patient’s written consent for the publication of this case report.

[scotianostra]

On February 6th 1665, Queen Anne, last of the Stuart monarchs, was born.

Anne had seventeen children during her life but not one survived to succeed her.

She spent her early years in France living with her aunt and grandmother. Although Anne’s father was a Catholic, on the instruction of Charles II Anne and her sister Mary were raised as Protestants.

In 1683, Anne married Prince George of Denmark. It was to be a happy marriage, although marred by Anne’s frequent miscarriages, still births and the death of children in infancy. She had many ailments during her life, one of which I can connect with, gout! A very painful form of arthritis, treatable nowadays but I know the pain and it is no surprise to hear she was carried around the court in a sedan chair, one source says

“she grew exceeding gross and corpulent. There was something of majesty in her look, but mixed with a gloominess of soul”

As I said earlier she there were seven times she miscarried and five children were stillborn, the only child to make it beyond being classed as an infant still died at 11, which must have been devastating for the couple.

Of the others, Mary died at just 17 months of smallpox, Anne Sophia was just 9 months when she passed away. William lived the longest and it must have been so hard on Anne, he was taken ill at his 11th birthday party when he complained of feeling tired, it was thought he was just tired from his exertions during the party where he had been dancing, later that night he had a sore throat and chills, followed by a severe headache and a high fever the next day. It wasn't till three days later a physician examined him and he was "bled", this was an ancient ritual and the young prince endured the withdrawal of blood from him in what was meant to cure or prevent illness and disease. His condition worsened and a second doctor visited on the morning of the 28th, that evening a third physician, the Queen's own, John Ratcliffe attended the boy. The three agree on a diagnosis, Scarlet fever, Smallpox were talked about, remedies of "cordial powders and cordial juleps" were administered and William was bled once more, to which Ratcliffe strongly objected to saying "you have destroyed him and you may finish him". Ratcliffe prescribed blistering substances, a painful method of draining away the black bile. Again it did not help his condition and he spent that night "in great sighings and dejections of spirits ... towards morning, he complained very much of his blisters."

Anne, who had spent an entire day and night by her son's bedside, now became so distressed that she fainted. However, by midday on 29th July he seemed to rally he was breathing more easily and his headache had diminished, leading to hopes that he would recover. The improvement was fleeting, and that evening, he was "taken with a convulsing sort of breathing, a defect in swallowing and a total deprivation of all sense". Prince William died close to 1 a.m. on 30th July 1700, with his parents beside him. In the end, the physicians decided the cause of death was "a malignant fever". An autopsy revealed severe swelling of the lymph nodes in the neck and an abnormal amount of fluid in the ventricles of his brain: "four and a half ounces of a limpid humour were taken out." A modern diagnosis is that he died of acute bacterial pharyngitis, with associated pneumonia. Had he lived, though, it is almost certain the prince would have succumbed to complications of his hydrocephalus.

Not to be put off the Queen gave birth to Mary on the 14th October 1690, the poor child was two months premature, and lived for only about two hours. George followed two years later, he lived a few minutes, just long enough to be baptised. A sad tale of trying to give her husband an heir.

Anne died on August 1st 1714 after a series of strokes, without that heir prompting parliament to pass the Act of Settlement to ensure a Protestant succession. Anne was therefore succeeded by the German Protestant prince George, Elector of Hanover.

The Stuart line of Kings and Queens was at an end, although many supporters of the Stuarts refused to recognise the Hanoverian succession giving rise to the Jacobite uprisings of the 18th century

[acknowledgetheabsurd]

It is only 3 o'clock. And yet the day has already been busy. I slept well but perhaps not enough. So I woke up with a raised eyebrow and it took me a long time to realize that the sun was in my eyes. I woke up and, after seeing my father, tired and discouraged to see him suffering again and again, I decided to go up to my little green room to make arrangements and wait there in any action for the arrival of the doctor. Upstairs, I had to stop for a second in my impulse. There was sunshine and a festive air... and you, everywhere. A hint of sharp pain, insurmountable nostalgia and a suffocating sweetness forced me to take back a lost moment.

I stayed there until noon and when I came down, I would have been at a loss to say what I had done there. I float in a kind of plenitude, in this life pushed to the paroxysm that you made me know and where joy, sorrow, hope, despair, desire, nostalgia, recognition, satisfaction, everything mixes, exhausting everything, pushing everything, devastating everything to make everything be reborn and start again. I needed you. I screamed, I screamed; I needed you to hear me and answer my call. O happiness! The answer was there: your two letters from Monday and Tuesday were there and they were just as I wanted them.

There are times when death doesn't mean anything anymore, and before I go any further and move on to less happy events, I want to answer your letters first. Don't be afraid, my darling. Luckily, life still loves me enough to never abandon me, and the fact that I even complain about it and revolt against this boredom that is winning me over and this desert where I am struggling is proof of this. What would I have to ask her if I didn't feel her value in me, her echo near or far? And then... those who are born alive, die alive and I even wonder to what extent life does not go beyond their existence... but where am I going? Forgive me, my love; I am going astray. I just wanted to assure you of something that you never doubted; even at the moments when I feel the deadest soul, a thousand embers are there that fizzle in silence and that all the ice in the world would not reach. These thousand embers, I reserve them all for you. They are waiting for you, as well as the ashes - alas.

As for the external life that you advise me, this one is too indifferent to me at this moment. It does not exist. My desires can't touch her at any minute. I regret, moreover, because it distracts me, perhaps, and I must say and confess that during this absence I have only one idea: to distract myself, because the pain I feel is too acute to find the slightest pleasure in it and my courage is a little weakened after these last months of tiredness. I'm glad you rented a piano. It is a living soul, suddenly installed in the house. I didn't know that F [rancine] could play so well.  Why doesn't she work?  Push her again. Give her the boldness she may lack. If she can do something big, it would be a real pity to stop along the way. How are the children? And your mom? And your brother, should he still be with you?

But these questions bring me back to my day and the sad events of the morning. The doctor, who has recovered from cystitis, came this morning to see my father who has had a sore throat and a slight fever for two days. Alas! An infectious pharyngitis has just set in and blurred everything again, before the first serum injection. All this would be nothing if he didn't suffer from it, but it is very painful and complicated by the fact that he can't breathe well except through his mouth, which dries out his already wounded throat. Moreover, he, who is never hungry, no longer eats, having too much difficulty swallowing, and all the admirable patience he has shown up to now has disappeared and has given way to an impotent revolt that I can't look at for long without having my heart in a vice.

We will start the aerosols again tomorrow and from this afternoon the nurse will come every three hours to give him extra shots of penicillin. What misery, my love! What misery! If you only knew! Finally, I always hope, with all my heart, that a day will come for him when he will feel at least a little relieved, and that he will not leave this earth without having again shared moments of rest. For the moment it is especially necessary to arm oneself with patience, to help him, as much as possible, to find his own and to wait. But there are hours when one no longer understands this continual crushing that is inflicted on him and that nothing can justify, and then one would bite if one had something to bite. Here we are.

But the clock is ticking and I must begin the cure. Maybe tonight, if I'm not too tired, I'll write to you again. The more I hate words, letters, paper, ink, the more time passes and these words add up to each other, the more I feel the need to write to you. It is incomprehensible. I love you, my darling, my love, my beautiful love. Oh, no; I don't want to beat you today, but I want to kiss you, kiss you, kiss you again, kiss you until I lose my breath and until you are in front of me and I can't push you away because of my lipstick. Ah, that day! This moment!

Maria Casarès to Albert Camus, Correspondance, February 2, 1950 [#165]

[jyou-no-sonoko19]

Hello everyone who reads my work, I'm so sorry, I couldn't get the next chapter of SoL out before I flew and just after landing I developed a horrid sore throat which a local clinic said is acute pharyngitis *and* laryngitis, and it's felt like swallowing shards of glass for three days now, just with spit, not even food. I'm at my wits end yet SoL's been sitting open on my laptop since landing, just waiting.

This wasn't the plan.

[tuxebo]

the true american experience is getting acute pharyngitis, going to rite-aid to pick up your meds, and getting ice cream from the little parlor they have <3

[moonrevolutions]

also everything is going wrong because i got diagnosed with cobblestone throat / acute pharyngitis! a lot of the symptoms triggered by stress. which is.... understandable.... ive been fighting to get my moms house away from her shitty fucking ex and im absolutely over talking to lawyers, but man the way this shit has impacted my health is pretty nutty.

i wish i could be more present here since i do work from home. but i just feel focused on work and my hobbies feel like a distant memory almost.

[ayuvogue]

The upcoming shows in Hyogo and Kyoto have been postponed due to poor health.

Ayu developed a throat condition leading up to her birthday show in Kanagawa, and after seeing a doctor, was diagnosed with acute pharyngeal laryngitis and acute sinusitis. The official announcement stresses that Ayu herself wished to continue but management insisted they postpone to prevent further damage to her health. Details about replacement performances are TBD; current tickets will be honored for these rescheduled shows.

[mcatmemoranda]

Centor criteria (determines the need for strep testing and culture): 1 point for fever, tonsillar exudates, tender anterior cervical lymph nodes, absence of cough, and age <15. Subtract 1 point if age >44. Score of -1 to 1: no antibiotic, no throat culture. Score of 2 or 3: throat culture, treat with antibiotic if throat culture is positive. Score of 4 or 5: treat empirically with antibiotic. Complications of strep throat include acute rheumatic fever, and post-streptococcal glomerulonephritis. Tx of strep throat will prevent acute rheumatic fever, but will not prevent post-streptococcal glomerulonephritis.

From UpToDate:

Importance of treatment – Group A Streptococcus (GAS), or Streptococcus pyogenes, is the leading bacterial cause of tonsillopharyngitis in adults and children worldwide. GAS is one of the few causes of tonsillopharyngitis or pharyngitis for which antibiotic treatment is recommended.

The goals of antibiotic therapy for GAS pharyngitis include symptom relief, preventing complications, and preventing transmission to others.

●Whom to treat – We recommend antibiotic treatment for any patient with symptomatic pharyngitis or tonsillopharyngitis who has a positive rapid antigen test or culture for GAS (Grade 1A). We generally do not treat patients who do not have microbiologic confirmation of infection or who are chronic carriers.

●Treatment recommendations

•Preferred treatment for adults – For most adults, we treat with oral penicillin V 500 mg two to three times daily for a total of 10 days. Penicillin is the treatment of choice for GAS pharyngitis due to its efficacy, safety, narrow spectrum, and low cost.

•Preferred treatment for children – For most children, we use either oral penicillin V or amoxicillin. Amoxicillin is often preferred for young children because the taste of the amoxicillin suspension is more palatable than that of penicillin.

•Treatment for patients with a history of acute rheumatic fever – For patients with a history of acute rheumatic fever or for those who may not adhere to oral therapy, we select among oral penicillin, oral amoxicillin, or a single dose of intramuscular penicillin based on drug availability, cost, and patient values and preferences.

•Alternatives for patients who cannot tolerate penicillin – Cephalosporins, clindamycin, and macrolides are alternatives for patients who are allergic to penicillin or who cannot otherwise tolerate penicillin. Selection among these agents is based on the nature of the drug allergy or intolerance and local antibiotic resistance rates.

●Symptom resolution and return to work – Fever and sore throat typically resolve within one to three days. Most patients can return to work, school, or daycare after 12 to 24 hours of antibiotic therapy, provided they are afebrile and otherwise well.

A test of cure is usually not needed for patients who are asymptomatic at the end of a course of antibiotic therapy, except for those with a history of acute rheumatic fever or in other special circumstances.

●Management of persistent symptoms after a course of antibiotics – For patients who have persistent or recurrent symptoms after completing a course of antibiotic therapy, we repeat microbiologic testing when symptoms are compatible with GAS infection. Because chronic GAS carriage can occur after antibiotic therapy, we generally avoid testing in patients who have symptoms that are more compatible with viral pharyngitis or other etiology.

For patients with microbiologically proven recurrent or persistent GAS pharyngitis, we repeat a 10-day course of antibiotic therapy (Grade 2C) and generally select an antibiotic that has greater beta-lactamase stability than the one used initially. Tonsillectomy is rarely indicated for such patients.

●Prophylaxis for patients with a history of acute rheumatic fever – Antibiotic prophylaxis is used for patients with a history of acute rheumatic fever because these patients are at high risk for recurrence and for the development of chronic valvular heart disease. Antibiotic prophylaxis is not recommended for chronic carriers, except in special circumstances.

[linggluu]

Woke up briefly from this nap at like 7pm, thought it was 7am TOMORROW lmao.

Anyways I have acute pharyngitis aka a super sore throat but not strep. Got a lidocaine mouth rinse and a nose spray both of which I used to make 😭 miss those days

[stevenwilliam12]

Beyond Dystrophin: Targeting Utrophin as a Therapeutic Strategy

Duchenne muscular dystrophy (DMD) is a severe genetic disorder characterized by progressive muscle degeneration due to mutations in the DMD gene, which encodes dystrophin. While dystrophin replacement therapies have garnered significant attention, an emerging strategy focuses on the upregulation of utrophin, a protein closely related to dystrophin. This approach presents a promising alternative for addressing the underlying pathology of DMD.

Understanding Utrophin

Utrophin is a protein that shares structural similarities with dystrophin and plays a crucial role in muscle function. It is primarily expressed during embryonic development but is significantly reduced in adult skeletal muscle. Interestingly, utrophin is capable of compensating for the lack of dystrophin, providing a potential therapeutic target. Research has shown that increasing utrophin levels can stabilize muscle fibers, reduce muscle damage, and enhance muscle function in preclinical models of DMD.

Mechanisms of Utrophin Upregulation

Several strategies are being explored to increase utrophin expression in muscle tissues. One promising approach involves small molecules that can activate utrophin gene expression. Compounds like the dystrophin-promoting compound (DPC) and others have shown efficacy in enhancing utrophin levels in various models. Additionally, gene therapy techniques, including adeno-associated virus (AAV) vectors, are being investigated to deliver utrophin coding sequences directly to muscle cells. These methods aim to stimulate the production of utrophin as a means of compensating for the absence of dystrophin.

Advantages of Targeting Utrophin

Targeting utrophin offers several advantages over traditional dystrophin replacement therapies. First, utrophin's ability to functionally compensate for dystrophin means that enhancing its levels could address the underlying issues in muscle fibers without needing to restore dystrophin completely. Furthermore, because utrophin is expressed in all muscle types, therapies aimed at increasing its levels may benefit both skeletal and cardiac muscles, potentially improving overall patient outcomes.

Challenges and Future Directions

Despite the promise of utrophin-based therapies, several challenges remain. For instance, achieving sustained and effective upregulation of utrophin in muscle tissues requires robust delivery mechanisms and dosage strategies. Additionally, long-term safety and efficacy must be established through rigorous clinical trials. Nonetheless, ongoing research and advancements in gene therapy and pharmacological approaches are paving the way for utrophin-targeting strategies to enter clinical practice.

In summary, targeting utrophin represents a significant shift in the therapeutic landscape for DMD. By focusing on this related protein, researchers hope to provide a viable alternative or complement to existing dystrophin-centric therapies, ultimately improving the quality of life for individuals affected by this debilitating condition. As the understanding of utrophin and its potential continues to grow, so does the hope for more effective treatments for DMD.

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