#Targeted Re-sequencing

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Genomics Market - Forecast(2024 - 2030)

Global Genomic Market Overview:

A genome is the genetic material of an organism. It includes both the genes and the noncoding DNA, as well as mitochondrial DNA and chloroplast DNA. The study of genomes is called genomics. The genomics market is gaining traction owing to its applications in various fields of study such as intragenomic phenomenon including epistasis, pleiotropy, heterosis, and other interactions between loci and alleles within the genome. In this era of medical and life science innovations shaping itself as an inevitable uptake for sustainability of mankind, the genomic research is poised for exponential growth owing to imperative genetic innovations feeding off it. Abundant potential has driven this arcade to reach a staggering market size of $16 billion - $16.5 billion as of 2018, and the demand is estimated to increment at formidable CAGR of 9.2% to 10.2% during the forecast period of 2019 to 2025.

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Global Genomic Market Outlook:

Genomics is extensively employed in healthcare, agriculture, biotechnology, DNA sequencing, and diagnostics. In the healthcare segment, genomics is used for the development of vaccines and drugs. This segment leads the application vertical and is growing with a CAGR of 10.1%-10.7 % through to 2025. Genomics plays a significant part in diagnosis of several genetic disorders. It has an ample scope in personalized medication as it can advocate a medical management constructed on the genetic face of a person with the help of clinical data and AI.  It is also applied in synthetic biology and bioengineering. Genomics research in agriculture is hired for plant breeding and genetics to cultivate crop production. The understanding of gene function and the accessibility of genomic maps along with an enhanced understanding of genetic variant will aid the plant breeders to identify the traits and then manipulate those traits to obtain a high yield. All these factors affecting the enormous medical and agricultural sector are all set to stroke the genomics market with abundant demand.

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Global Genomic Market Growth Drivers:

As per the National Center for Biotechnology Information, U.S, the progression in oncology (study and treatment of tumor) expenses is forecast to rise 7%–10% annually throughout 2020, with universal oncology cost exceeding $150 billion[1]. As per the WHO, cancer is a leading cause of death worldwide, accounting for an estimated 9.6 million deaths in 2018[2]. And the total annual economic cost of cancer at the initial period of this decade was estimated at approximately $1.16 trillion. Thus the application of genomics in exploring cell-free circulating DNA by several R&D sectors as a potential biomarker for cancers is driving the market towards exponential growth. The genomics market with its current potential displays all the necessary traits it can adapt in the coming years to divert a huge chunk of traffic and revenue from the omnipresent cancer diagnostics.

As per the Food and Agriculture Organization of United Nations, between 1960 and 1990 the arable land increased by 1.5 billion ha, and in the recent past decades the elevation recorded is just 155 million ha[3]. With decreasing arable floor and the increasing global population augmenting the demand for food by 70% (by 2050), obtaining a high yield is a major trend in the agricultural sector. Genomics market is all set to capitalize on this unprecedented demand scenario. Genomics supplements the understanding of gene function and the accessibility of genomic maps along with an enhanced understanding of genetic variant, thus aiding the plant breeders to identify the traits and then manipulate those traits to obtain a high yield.

After an acute analysis of the regional insights of the global genomics market, North America is revealed to hold 39% to 40% of the entire global market size as of 2018. Such dominance can be attributed to several aspects such as cumulative investment on research by federal administrations, growing patient awareness, and accessibility of urbane healthcare facilities.

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Global Genomics Market Players Perspective:

Some of other key players profiled in this IndustryARC business intelligence report are Beckton Dickson, Synthetic Genomics Inc. (SGI) ,Cepheid, Inc., Affymetrix, Inc., Bio-Rad Laboratories, Inc., Agilent Technologies, GE Healthcare, Illumina, Inc., Danaher Corporation,F. Hoffmann-La Roche, QIAGEN, Thermo Fisher Scientific and PacBio (Pacific Biosciences of California). Majority of the companies mentioned are situated in North America augmenting the regional affluence in the global market.

Global Genomics Market Trends:

High overload owing to a wide range of reagents and consumables has propelled companies into approving different policies to endure in the market and stay ahead of the curve.

For instance, in January 2017, BD launched Precise WTA Reagents for precise and guileless quantification of hereditary data form single cell analysis. Moreover, in July 2016, SGI-DNA entered into a distribution agreement with VWR International, an American company involved in the distribution of research laboratory products, with over 1,200,000 items to more than 250,000 customers in North America and Europe.

Genomics Market Research Scope

The base year of the study is 2018, with forecast done up to 2025. The study presents a thorough analysis of the competitive landscape, taking into account the market shares of the leading companies. It also provides information on unit shipments. These provide the key market participants with the necessary business intelligence and help them understand the future of the Genomics Market. The assessment includes the forecast, an overview of the competitive structure, the market shares of the competitors, as well as the market trends, market demands, market drivers, market challenges, and product analysis. The market drivers and restraints have been assessed to fathom their impact over the forecast period. This report further identifies the key opportunities for growth while also detailing the key challenges and possible threats. The key areas of focus include the types of equipment in the Genomics Market, and their specific applications in different phases of industrial operations.

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Genomics Market Report: Industry Coverage

Types of Solutions Genomics Market:

By Product Types- Microarray chip, Sequencers.

By Application- Genotyping, SNP analysis.

By End-User- Anthropology, Diagnostics.

The Genomics Market report also analyzes the major geographic regions for the market as well as the major countries for the market in these regions. The regions and countries covered in the study include:

North America: The U.S., Canada, Mexico

South America: Brazil, Venezuela, Argentina, Ecuador, Peru, Colombia, Costa Rica

Europe: The U.K., Germany, Italy, France, The Netherlands, Belgium, Spain, Denmark

APAC: China, Japan, Australia, South Korea, India, Taiwan, Malaysia, Hong Kong

Middle East and Africa: Israel, South Africa, Saudi Arabia

[dreamofhircine]

The pilots are not government property, that's a common misconception.

Only their training is.

They get to keep the implants, the neural interface ports, the subdermal autoinjectors (depleted of chemical supply) even the targeted brain & optical augments that bump up their reaction speeds but the training data is too important to allow for uncontrolled proliferation or mercenary employment.

They take it back the same way they put in in: hypnotherapeutic memory injection, cracking open the deepest parts of their minds with carefully calibrated sequences of light and sound and highly compressed data that slowly spools out inside them, guided along the decompression and integration sequence by highly controlled training sequences and neural test patterns.

The problem is that they don't really have anything to put back in once they've sanitized the mind of lifetimes worth of cockpit experience and subconscious conditioning, they don't have a 'happy civilian' template equivalent to the Pilot Template that they inject into and mold the recruits around so most leave the process with barely two thoughts to rub together for warmth. All the wiring is still there, the neurons are (mostly) undamaged and firing but it'll be years before all the rights memories are re-seeded and all the correct pathways re-forged to create something as functional as they were when they started.

So yeah, they drool. They twitch. They stare at walls and space out, drop conversations mid-sentence, fall asleep standing up and forget nearly any set of directions you give them but they'll get better. Probably. Eventually.

[ratgrinders]

re oisin, i still wanna know why he apologized to adaine in the cafeteria. was he trying to smooth ruffled feathers bc jace said so? was he genuinely at least a little regretful that he was about to help kipperlily fuck up their last stand exam? i feel like him and maryann really havent shown their rage at all (yet, rip maryann's strawberry) and i was hoping to get some kind of indication of his actual feelings about the bad kids

oh this is so true, yeah if i'm remembering correctly the sequence of events in the cafeteria are:

kipperlilly picks a fight with kristin -> bad kids debate amongst themselves over which rat grinders suck and which are good -> adaine says "well what about the wizard one he seems cool!" -> Every One of the bad kids pointing out oisin to Adaine -> Oisin opening his mouth like he's going to say something but saying "sorry" instead.

so like, did oisin see evidence that any sort of resentment he felt towards adaine was not returned and felt guilty? was he originally going to say more but the reminder of the bad kids' presence kept him from saying it? like its especially interesting to me that it's done in response to a compliment adaine gave him, and what was he originally going to say!!

and ditto on his actual feelings towards the bad kids. we know all about kipperlilly's motivations but barely any on the others. even his feelings on adaine specifically, like going out of his way to taunt her with a sending spell at fabians birthday party. that seems VERY targeted, and we still dont really know why!

[beaniebitch01]

RANT!!!

*This will contain spoilers for Sonic Prime*

So I watched this show once before but held off writing my thoughts on it until I re-watched it cause on first watch I'm not really thinking of the show in a critical manner so it'd just be a disjointed string of random thoughts I had. It's also because any grievances I had may not have been fair when you consider the target audience this show was made for. So with that in mind I re-watched it and can now make a (hopefully) fair review of it.

I'm gonna start with what I thought was bad because considering it's a 3 season series I don't have a lot of complaints so I'll just get them out first.

1)The villains were dumb like what purpose does 5 eggmans serve besides obnoxious arguing. It would've been much more interesting if each world had its own version of eggman. Even the baby would've been a funny character if it was the sole villain for one of the worlds. 2)The fight scenes were repetitive. 3)Dialogue was actually painful sometimes, but this was made in an age where people for some reason think kids can't comprehend real conversations so they insert dumb quips. 4)*shudders*The Baby™. As sonic said in season two, "how can one baby be so hateable". Never in my life have I wanted to punch a character so bad. Every time it was on screen I felt a burning flame of hatred in my soul. 5)The ending, especially the last few episodes, went back and forth between Sonic trying to convince Nine to stop and the same fighting sequences and it got so annoying i thought about fast forwarding to the end. The stakes never felt high or low, they felt the same for all 7 episodes.

The good:

1)Shadow!!! He's in a show for more than a few episodes!!! Bro is always angry but honestly if I had to deal with sonics shenanigans I'd be perpetually annoyed too. 2)It was pretty well paced. Season one introduced all of the alternate worlds, season two had sonic switching between those worlds trying to get all of the crystals back and revealed a twist villain, season three was the fight against that villain and restoring the shatter space. 3)Considering the other shows we have, the animation wasn't bad, but could've been better. Especially when Netflix has come out with stuff like Arcane whose animation was incredible. 4)The plot was cohesive. 5)Good twist villain. Even though you can see it coming from the first episode of the first season, Nine still made for a good villain. 6)I was surprised to see actual character growth. Sonic's was inevitable since his carelessness got them into the situation they're in. Nine's character changed with each season, starting with being untrusting and guarded in the first, calming down in season two and actually caring about Sonic's wellbeing, feeling betrayed and angry in season three and then finally realizing he done goofed and Sonic was always his friend. 7)I really like that the one common thing from all worlds is the one palm tree. This feels like a weird thing to comment on but I just found it sweet for some reason.

Overall I really enjoyed the show and def recommend it.

[dangermousie]

My Dearest looked at Scent of Time and said "hold my beer." This is honestly how you show so much in so little.

We finally get a proper flashback as to how Ryang Eum came to be with Jang Hyun and it's a doozy. Because RE was being kept (yes, the way it sounds) as a child (!!!) by some psycho noble. And said noble got jealous of attention from someone else so was branding a small kid (!!) and we see teen Jang Hyun, a fellow servant there.

The way he asks this shows what this household is like in one short sentence - that cruelty and insanity are just routine.

And then as the master keeps torturing his small child abuse victim, something in JH snaps and without any warning, and completely calmly, he smashes the man's head in. I cheered.

No wonder RE is forever JH's - he saved him from hell, the first time anyone did. And this sequence is so telling about so many things and the basics of JH's character are already there - even here, JH offers RE a choice, even here he's calm and competent under pressure and has a plan and he is someone who is patient but then whatever arbitrary line is crossed and he will just do anything to take the offender(s) down - the teen who likely murders their master for abusing his slave (if he's caught, a horrifying fate awaits), is the man who hunted and killed a troop that murdered the grandpa who sheltered him in his house, the man who tracked GC alone to that island while sick with the freaking plague etc etc. He can be teen or adult, poor and powerless or wealthy and powerful, but there is a core of pure absolutist steel in him.

You know what I truly love? This flashback shows that despite his present silks and fans, there might not be a drop of noble blood in JH. And regardless of that, he's more competent and full of humanity than the bulk of nobles we meet. I love the narrative expectation that no, of course, he's a fancy noble because when we first meet him, this is what he presents as. And then.

Once again, it makes me think of this writer's previous Rebel. Where the King finally meets his foe Hong Gil Dong and is appalled when HGD says that no, he's not an illegitimate scion of a noble house or anything else approaching blue blood. He's a servant and son of servants, not a drop of blue blood. And the King refuses to believe it. Because he can believe a political challenger or an illegitimate son of aristocracy with a grudge against not being given the place he thinks the noble part of his blood entitles him to, but someone with no blue blood at all? He can't.

(It also makes me think of my favorite scene in cdrama Ever Night, where the Emperor and his court assume our ML on his revenge quest is the son of the general wrongfully murdered with his family and household, and ML reveals no, the general's son is long dead, he's the son of the porter and maid of that house who also got slaughtered in the household as part of general murder spree, not targets or anything but collateral damage. Why can't a servant's son seek revenge, he asks, and you feel the narrative stutter gloriously.)

Anyway, this drama is EVERYTHING!

[limnsaber]

Re Amor Fati: what the fuck was that. I have more things to say and more things to think about and no idea how to say them.

I feel like that was the first time mytharc really faltered. Not that it was impervious before, but something abt it wasn’t on target this time

David Duchovny I know you have things to say what did you mean. I’m going to need to have that percolate for a minute

Spoilers (for the mutuals) below:

Mulder always throws in with CSM when he’s at his lowest

The sequence with Diana and Mulder’s faux dream world makes much more sense if Diana and Mulder had been married in the past

Really interesting stuff with keys, and the truth, Mulder’s idea of deserving and fate. Ultimately where I think mytharc is faltering is that it can’t deliver anything concrete, but it’s trying to, and in doing so it’s becoming more aligned with the Syndicate. I have to rephrase that. Hmm. It’s like this with Mulder’s dream too, there are things there he didn’t want and things there that he did. And still the truth is Scully

I think the extraterrestrial vessel was both things at once — extraterrestrial and a fraud. The Syndicate’s guys and Mulder’s dream land talk about God’s plan, and playing God, and the idea that everything was orchestrated is not the truth.

Though maybe Scully’s thesis might say otherwise. Not in the orchestration, but in… where was it. “Although multidimensionality suggests infinite outcomes in an infinite number of universes, each universe can produce only one outcome.” Hmm. Fate, again.

“Hold on.” “Let go.” AGHHHHH Scully… CSM when I get you.

Oh. One more thing. I imagine: when Mulder was lying on that table and Scully was pleading with him, even while he had just been cured of his paracognitive ability he heard I love you as clear as any truth he’d ever known.

[dragon-snoots-a-boopin]

Resident Evil 6 is the worst RE game experience that I've ever had. Here are all the reasons that I believe this true based on my experience with the game.

There's a cutscene like once every two minute. It's excessive. This is a game, not a movie.

There are a lot of QTEs

The game doesn't look, feel or play like any kind of horror game.

The characters are so over the top in how they act that it's hard to take any of the seriously.

You have to zoom in to even shoot one of your guns, otherwise you'll just trigger melee attacks.

General aiming is so slow too. Like it's slow to aim and move from target to target and that is not good, especially for the amount of fast moving enemies in the game.

The sniper rifles have such and over the top and unrealistic amount of scope sway that it makes sniper rifles unusable.

The camera is god awful. Some characters have the camera set in a way to be over the left shoulder and yes, you can change it, but if you open a two person door or transition out of a cutscene, the camera will reset back to over the left shoulder which is annoying. There's so much camera shake when sprinting that it makes it hard to run in a straight line. The camera is also 98% responsible for the fact that an escape sequence in the 5th chapter of Chris's campaign is impossible as the camera keeps changing position and angle so frequently that I get stuck on walls and fail so much that I skipped this and never finished that campaign.

Not a fan of the skill point system because this system affects how much and what kind of ammo drops from enemies and that is annoying.

The escape sequences just suck in general. The one in chapter 5 of Chris's campaign is the worst but the snowmobile one in Jake & Sherry's campaign was also infuriating too. I don't know why these require so much precision to not fail but they do and it's stupid and I hate those sections.

I've played a total 6 RE games, seven if you count this one, and none of those games have come close to the piss poor experience of a game as RE6 has shown me to be, not even Revelations 2. I would definitely NOT recommend this game to anyone, even if you're a fan of the franchise.

[your-local-squip-fanatic]

You know what, I have had zero motivation for writing, BMC is eating my brain, and figuring out what to do with DLAU is killing me. So I say screw it, I'm sharing some of my plans.

Lester's Connection to Commodus- This whole plotline is why I dread STL, Save the Light (No, I did not get it from SU, I forgot that game even existed. It's not even the finalized title). I STILL don't know how exactly to handle it. Basically, I wanted Lester to have SOME personal stake when it came to the emperors, even more than Eliza. So I came up with this: back in ancient times, Lester had an ancestor named Belenus that wandered Greece and, against the advice of his father, went to Rome. Angry at how the gods had been changed, he tried and failed to speak against it, and was sentenced to be a gladiator. Praying to Apollo every day for release, Belenus eventually got good enough that Marcus Aurelius thought about letting him free.

Then. Y'know. He died and Commodus became emperor, and we know that Commodus fought gladiators all the time. Eventually Belenus had to fight Commodus, and was unsurprisingly killed. With his dying breath, he cursed Commodus, saying that the last face he would see would see would be his own. That is, Belenus'. A thousand years later, guess who looks nearly exact to Belenus and has become Commodus' big target, just as important as Apollo?

At first, Lester obviously CANNOT hope to fight Commodus. He tries this, he gets his ass kicked. Again while defending the Waystation and would've been decapitated by the emperor if not for Apollo managing to reveal his godly form. In BMR, Lester's toughened up and out for blood after Jason's death (yea, he goes from sweet to murderous after the yacht infiltration. Buckle up boi) and can actually manage Commodus better until he gets stabbed IN THE DAMN LIVER AND IS HOLDING ON TO HIS THREAD FOR DEAR LIFE FOR APOLLO'S SAKE. That fight is one I really look forward to.

Admittedly yeah, kinda needless plotline with Belenus but STILL. I'm figuring things out, so not everything is final.

The Scene We Don't Talk About- You know it. I just mentioned it. Again, not everything in this post is final, take this with a grain of salt.

Jason's death is going to be a huge moment development wise for Lester too. As I said, in the aftermath Lester will become hellbent on killing Caligula- whether or not he gets to, idk yet, but I have a funny idea for if Lester does:

Caligula: I'm still alive! (gets killed by Lester)

Lester: Not anymore, you're not.

Yep. Lester changes DRASTICALLY after the yacht stuff. But funny enough, the whole sequence is one of those that I don't need to change much but I also have to change a lot of it. It's still very early in planning, but the idea right now is Lester eventually has to race over to boat twelve in order to save them, fails, endures the heart stabbing thing by Apollo (they share wounds if they're serious enough!), see Jason die, try to attack Caligula, and end up nearly dying fron pandai arrows to save Piper and Apollo. Lester's last conscious words to Apollo after three arrows in back and being drifted to safety by Tempest are: "You would've done it too."

Apollo's changing a bit, and Lester sees that. He's trying to help that change along the best he can and support Apollo after such a horrible event.

The Final Battle For Delphi: Apollo and Lester VS Python- Ohhh man. At first when making DLAU, I figured that I'd omit this as I didn't think I could fit Lester in the fight. But after careful planning, I realized I possibly could- but maaaan, it wasn't going to end well. Lester simply isn't built the same as Apollo by this point (he has his glowy gold eyes back by now! In Lester's body!!) and is reduced to a bloody, broken mess once we get to the part with Chaos. He fights hard beforehand, but Python is just WAY too much for him, plus, y'know, they're in a volcanic atmosphere or something?! (I need to re-read ToA soon, goodness.)

Of course, Apollo takes a hell of a beating too, but he's not the one on death's doorstep. As he's turning back into his golden godly form, he's weeping and DESPERATELY trying to heal Lester. Of course, because happy ending, Lester does survive by the skin of his teeth thanks to what healing Apollo could manage, though was hospitalized for a while. He later reunites with his demigod pals and shares a happy cry with Apollo once they see each other.

The ending will be much of the same as in canon ToA, but it ends with Lester finally going back to his parents, his family, and embracing his quirks about himself. The message from the ending is one that I think is too relevant to not share now, given what's happened.

Lester breaks the fourth wall a bit, telling the reader that everything that happened was indeed true. He reflects a bit on the insane adventure he had to go through to get a second shot at life, and tells us not to squander ours, since we're not as lucky to be given two chances- we get one, and that's final. A few words from him about accepting and loving yourself, stuff he wished he had before, and basically tells us to not be afraid to be ourselves and stand up for what we believe in, that no evil will persevere forever, and that ANYONE can make a difference. After all, without him, Apollo couldn't have made it back to Olympus.

And of course, his eternal words of wisdom that to this day I am so damn proud over: "Hope to see the sun rise."

There we go! There's just a few. If you're interested to hear about my other plans for scenes I'll change or add, don't be shy and ask!

[bylrlve]

To add to yesterday’s observations about Will and how his feelings for Mike are being hammered home, there’s an insane sequence in the VR game - Chapter 4, the good stuff is from 50:00 onwards. To put it concisely: Vecna tauntingly asks Will how to get to each of his friends, then tries to get into each of their heads by targeting their weaknesses. He uses Dustin’s friendship insecurity, but Dustin ignores him because he’s watching TV lmao. He uses Lucas’s desire to succeed, and tries to tell him that his friends are holding him back. However, Lucas is on a drive-in movie date with Max. he uses Mike’s guilt over losing El at the end of s1, and Mike doesn’t even seem to register Vecna’s presence in his mind. Why? Bc he’s too busy playing D&D with the boys, trying to get his Nana impression on-point. Two dice are rolled, one red and one rainbow, and those visually wipe away the Vecna part.

Vecna then returns to taunting Will, saying awful things about how he’s alone, his friends hate him, he’s going to rip him apart. Will’s nose starts bleeding heavily. Mike? Mike springs into action, grabs Nancy’s old white shirt, and physically wipes the blood off, getting super close to Will. His actions and words contradict what Will is being told by Vecna in that moment

I want to note something I haven’t personally seen observed. In this play through, anyway, it goes Dustin, Lucas -> Mike. Before Lucas and Mike, Vecna asks mockingly how to get into their minds. The nosebleed happens right after he tries and fails to get to Mike. We’re then treated to a full 90 seconds of Mike getting right up in Will’s face, tenderly wiping his face clean and asking if he’s okay, serving as the ‘light’, to quote Max, that drags Will from the darkness that is Vecna, that disproves everything Vecna says.

Is the implication that Vecna uses those tactics because that’s what Will thinks his friends’ big Achilles Heels are? What does that say for Mileven? I’d love insight from someone who’s played it.

Oh, and Mileven was low-key/high-key shaded in the Elmax section.

@will80sbyers has posts with screenshots of the full quotes.

(X, Y)

It’s very interesting that mileven is barely an afterthought, and treated very coldly and impersonally. To get to Mike, Vecna says, and I quote “more of that game. He’s distracted. You’ll never find her, Mike. The greatest person you’ve known forever is gone because you didn’t try harder. And now you’ll never know what could have been-” only for it to cut to Mike still talking about the particulars of his Nana impression. ‘Greatest person’, ‘cool’, ‘different’, ‘amazing’, only for any guilt re: her to not move him at all. Did I mention the consultant was Paul Dichter, story editor on 108 and every s2 and 3 ep, and main writer of Will the Wise and Dear Billy?

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[ineedlelittlespace]

for the ask game: ratthi murderbotdiaries?

Send Me a Character

Oh, Ratthi, my beloved...🥰

First impression

Like a lot of us, I only had eyes for Murderbot the first time I read ASR---the human team absolutely got shoved to my mental backburner while I was busy relating to MB. In the five seconds I did spend thinking about Ratthi, it was mostly in a "oh, so this is going to be the problem child, huh?" way when he almost walked outside into the worm's mouth.

Impression now

I love him, your honor.

But also, he is an all-around delightful human being. There's a kindness and an earnestness to his character that is just so endearing you can't help but like him, especially when you layer in the fact that he's excellent at his job, great at adapting to high-pressure situations on the fly, and has the people skills to successfully navigate the absolutely wild interpersonal interactions that the series keeps throwing at him.

Favorite moment

That whole sequence in Fugitive Telemetry where he and Gurathin drop everything to help Murderbot do some light breaking and entering. It feels like the equivalent of an errand hang-out, but if your bestie spends its spare time solving murders rather than picking up dry cleaning and going to Target. I love the implication that this is just what they do now, once Murderbot has settled into the group. Friends help friends with projects, right? So, obviously, Ratthi is going to help in whatever way he can.

Idea for a story

I kind of want to do more of his PoV for various scenes throughout the series. He's present for so many of the juiciest scenes---there's a lot to work with!

Also, it might be fun to do something with his friendship with Arada and Overse, perhaps with some backstory on their first meetings and how they moved from colleagues to besties.

Unpopular opinion

In all honesty, I don't feel like there's too much pressure re: popular vs. unpopular opinions in the Murderbot corner of the internet. The only thing that comes to mind with Ratthi is that I think we tend to...soften him a little too much sometimes. There's a tendency to focus mostly on his skill as a people person or a friendly face, not necessarily on the fact that if he wasn't so good at his actual job, he probably wouldn't be on Mensah's team. We see him tackle gory jobs like cleaning up the battle aftermath on ART in Network Effect, we see him jump into helping with medical emergencies, and in Fugitive Telemetry, he immediately identifies that "someone was dead here" when they come upon the scene of the murder because the physical signs are obvious to a biologist. As far as the humans of the series go, Ratthi is very capable!

Favorite relationship

Aside from the obvious friendship with Murderbot itself, I really do love that he's best friends with Arada and Overse. I love that these three stuck together for the next survey to follow the disastrous events of ASR. I love that their friendship is so obvious and loud that even Book One Murderbot could immediately point it out. I just really like seeing healthy platonic friendships (especially ones that coexist with and do not compete against healthy romantic ones involving some of the same characters), okay?

Favorite headcanon

The infamous "Who's this?" line from ASR was a full-on my-brain-is-short-circuiting-and-my-mouth-got-ahead-of-my-mind moment, not necessarily an ah-yes-a-stranger-to-be-introduced moment.

[zahri-melitor]

And thinking more on Tom King and the storytelling I've seen from him: the fact he is such a devotee to asynchronous storytelling really pops out to me.

Supergirl: Woman of Tomorrow is entirely framed as a retrospective narrative told by Ruthye looking back on the events that occurred during her quest for vengeance.

Mister Miracle has Scott practically unmoored from time, flashing between his memories growing up in Apokolips, recent past events, the progress of the peace negotiations between Apokolips and New Genesis and his home life with Barda and Jacob. The frequent travel between Earth and New Genesis really does not assist matters.

Grayson is one of the few stories I think he's written without much of this, though it does appear for Annual #1, and they drop into the story in media res for issue 1 and then backtrack.

Wonder Woman, though I've only read sections of it, is busy balancing present day storytelling with Trinity storytelling and promising/threatening how it's going to link up.

Batman not only has in media res stories, dream sequences, flashbacks, but also plot arcs where I couldn't instantly tell if we were in the main universe, an alternate timeline, a dark future or another part of the Multiverse. And sometime we WERE in an alternate timeline (the Booster plot) and others we were in a story predicated on time passing at different speeds between realities (the Diana plot) and sometimes it was elsewhere in the Multiverse (the Button plot) and so on.

Human Target, which I've only just started, once again sets itself up in a "here we are; time to talk about events that happened long ago and how they influence the plot going forward"...

And look, I think he's done interesting work with it. But I can't help but think some of his story arc work would be stronger if he spent more time on linear storytelling.

[covid-safer-hotties]

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Abstract Autoantibodies have been shown to be implied in COVID-19 but the emerging autoantibody repertoire remains largely unexplored. We investigated the new-onset autoantibody repertoire in 525 healthcare workers and hospitalized COVID-19 patients at five time points over a 16-month period in 2020 and 2021 using proteome-wide and targeted protein and peptide arrays. Our results show that prevalent new-onset autoantibodies against a wide range of antigens emerged following SARS-CoV-2 infection in relation to pre-infectious baseline samples and remained elevated for at least 12 months. We found an increased prevalence of new-onset autoantibodies after severe COVID-19 and demonstrated associations between distinct new-onset autoantibodies and neuropsychiatric symptoms post-COVID-19. Using epitope mapping, we determined the main epitopes of selected new-onset autoantibodies, validated them in independent cohorts of neuro-COVID and pre-pandemic healthy controls, and identified sequence similarities suggestive of molecular mimicry between main epitopes and the conserved fusion peptide of the SARS-CoV-2 Spike glycoprotein. Our work describes the complexity and dynamics of the autoantibody repertoire emerging with COVID-19 and supports the need for continued analysis of the new-onset autoantibody repertoire to elucidate the mechanisms of the post-COVID-19 condition.

[compneuropapers]

Interesting Papers for Week 30, 2024

A hippocampus-accumbens code guides goal-directed appetitive behavior. Barnstedt, O., Mocellin, P., & Remy, S. (2024). Nature Communications, 15, 3196.

Tuned geometries of hippocampal representations meet the computational demands of social memory. Boyle, L. M., Posani, L., Irfan, S., Siegelbaum, S. A., & Fusi, S. (2024). Neuron, 112(8), 1358-1371.e9.

Recurrent Neural Circuits Overcome Partial Inactivation by Compensation and Re-learning. Bredenberg, C., Savin, C., & Kiani, R. (2024). Journal of Neuroscience, 44(16), e1635232024.

Encoding surprise by retinal ganglion cells. Despotović, D., Joffrois, C., Marre, O., & Chalk, M. (2024). PLOS Computational Biology, 20(4), e1011965.

Neural and behavioural state switching during hippocampal dentate spikes. Farrell, J. S., Hwaun, E., Dudok, B., & Soltesz, I. (2024). Nature, 628(8008), 590–595.

Motor neurons generate pose-targeted movements via proprioceptive sculpting. Gorko, B., Siwanowicz, I., Close, K., Christoforou, C., Hibbard, K. L., Kabra, M., … Huston, S. J. (2024). Nature, 628(8008), 596–603.

Multisensory perception depends on the reliability of the type of judgment. Kayser, C., & Heuer, H. (2024). Journal of Neurophysiology, 131(4), 723–737.

Neuronal Ensembles in the Amygdala Allow Social Information to Motivate Later Decisions. Kietzman, H. W., Trinoskey-Rice, G., Seo, E. H., Guo, J., & Gourley, S. L. (2024). Journal of Neuroscience, 44(16), e1848232024.

A discrete component in visual working memory encoding. Park, H.-B., & Zhang, W. (2024). Journal of Experimental Psychology: Human Perception and Performance, 50(5), 464–478.

Directed and acyclic synaptic connectivity in the human layer 2-3 cortical microcircuit. Peng, Y., Bjelde, A., Aceituno, P. V., Mittermaier, F. X., Planert, H., Grosser, S., … Geiger, J. R. P. (2024). Science, 384(6693), 338–343.

Stimulus encoding by specific inactivation of cortical neurons. Pérez-Ortega, J., Akrouh, A., & Yuste, R. (2024). Nature Communications, 15, 3192.

Cortical cellular encoding of thermotactile integration. Schnepel, P., Paricio-Montesinos, R., Ezquerra-Romano, I., Haggard, P., & Poulet, J. F. A. (2024). Current Biology, 34(8), 1718-1730.e3.

Effects of reward and effort history on decision making and movement vigor during foraging. Sukumar, S., Shadmehr, R., & Ahmed, A. A. (2024). Journal of Neurophysiology, 131(4), 638–651.

On the timing of overt attention deployment: Eye-movement evidence for the priority accumulation framework. Toledano, D., Sasi, M., Yuval-Greenberg, S., & Lamy, D. (2024). Journal of Experimental Psychology: Human Perception and Performance, 50(5), 431–450.

Multiplicative joint coding in preparatory activity for reaching sequence in macaque motor cortex. Wang, T., Chen, Y., Zhang, Y., & Cui, H. (2024). Nature Communications, 15, 3153.

Encoding of Visual Objects in the Human Medial Temporal Lobe. Wang, Yue, Cao, R., & Wang, S. (2024). Journal of Neuroscience, 44(16), e2135232024.

Dopamine encoding of novelty facilitates efficient uncertainty-driven exploration. Wang, Yuhao, Lak, A., Manohar, S. G., & Bogacz, R. (2024). PLOS Computational Biology, 20(4), e1011516.

A primary sensory cortical interareal feedforward inhibitory circuit for tacto-visual integration. Weiler, S., Rahmati, V., Isstas, M., Wutke, J., Stark, A. W., Franke, C., … Teichert, M. (2024). Nature Communications, 15, 3081.

Oblique warping: A general distortion of spatial perception. Yousif, S. R., & McDougle, S. D. (2024). Cognition, 247, 105762.

Irreducibility of sensory experiences: Dual representations lead to dual context biases. Zheng, Y., Cooke, A. D. J., & Janiszewski, C. (2024). Cognition, 247, 105761.

[transmutationisms]

broad af question, but thots on the rise of epigenetics as a model? (i imagine youd be pretty sympathetic to mansfield and guthmans critique esp re: reproductive futurity)

you imagine correctly, lol. they're kinda frustrating because they don't really understand the relationship between epigenetics, eugenics, and social reform projects historically and aren't able to contextualise it in contemporary biology, but they're still right to point out that interest in epigenetics is primarily coming from a desire to enforce ideas of biological normality and ideals of strength / beauty / &c. what's lacking in the historical narrative is the fact that this type of environmentalism has been part of evolutionary biology more often than not; darwin and his contemporaries also believed in the inheritance of acquired characteristics, so really it was only temporarily displaced by the crude genetic determinism of the modern synthesis in the early 1940s, and this model was in serious disrepute by about 50 years later lmao. i also think mansfield and guthman, like most commentators on this issue, overstate the extent to which epigenetic inheritance is a 'lamarckian' idea (it's not, any more than mendelian genetics is 'darwinian' or evo-devo is the same as 18th-century recapitulation theory lmao).

anyway, regarding epigenetics itself, there's also a lot of overconfidence about the ability for biologists to actually determine which genes are being differentially expressed, how they influence one another, and what that means for the organism. if you even change, like, the length of dna sequence that the computer considers to be a gene, you get a radically different list, and even if you can identify a differentially expressed gene with confidence, determining what exactly it does is still incredibly hard. in practical terms, epigenetics is still confined mostly to similar kinds of epidemiological studies as nutrition science, and many of these studies are plagued with confounding factors and methodological weaknesses. the hope has long been that by identifying epigenetic changes, we could develop targeted therapies. but this is basically a moonshot imo (like, literally no one knows which parts of gene expression to target or how, ever) and also raises the extremely thorny question of: what things, exactly, are we hoping to 'fix'? more often than not, as m&g point out, this type of research is driven by interest in enforcing thinness, specific neurological and affective states, &c. not to say there's NO epigenetic research being done on diseases that would actually be beneficial to cure, but epigenetics has a eugenic bent (because public health has a eugenic bent) and is specifically being funded that way.

although i disagree, like i said, that epigenetics is really lamarckism (& dislike the work of jablonka and that crowd for this exact reason lol), you can certainly contextualise the rise of epigenetics in the longer history of disputations over the role of the environment in determining the condition of the organism. life sciences and medicine have grappled with this issue in many different forms; for instance, hippocrates's non-naturals suggest environmental and climatic influence, galenic humoural theory leans on internal regulation with the environment as an external disruption, germ theory offered what appeared to be a non-environmental theory of disease that was promptly synthesised with sanitary-environmentalist hypotheses by the french hygiene profession. within evolutionary biology specifically, ideas of plasticity within an organism's lifetime have never really gone away, and the dispute was essentially over the extent to which these changes were hereditary. epigenetic theory fits comfortably within this ongoing debate, and if more biologists understood that then they would understand why their work bears such a strong resemblance to so many previous eugenic projects.

[brionysea]

any characters specifically?? there's so many lol

ooo i was mainly thinking abt (what i call) the gang- Lucas, max, dustin, el, Mike, will etc- and possibly Nancy if that’s okay? im sorry if this is too much to ask of you and I hope you have a great day!!!!! :D

lucas

colour - green

deepest fears - ??? idk. assuming this is for a vecna fic or something, i guess play around with whatever's happened at this point in the timeline. seeing max die is a huge one, and all the "being violently targeted by insane white boys for daring to Exist While Black" is bound to have taken a toll on him (not that canon's acknowledged any of it, of course)

aesthetic - uh... basketballs. they look good on the aesthetic moodboard for him in my brain right now

max

colour - orange and/or rainbow. the first part might just be because i'm obsessed with red hair (hello, childhood obsession with the little mermaid and red-haired!paige from charmed), but max wears a LOT of rainbows

deepest fears - becoming like billy (continuing the cycle of violence) and that her friends (and mother) think she deserves the same fate as him (dying horribly and painfully via the upside down and traumatising someone as she does). season 4 was great for her :)

aesthetic - skateboards

dustin

colour - ???? my brain is saying blue but i have no idea. maybe someone in the notes knows?

deepest fears - probably a loss of control. he likes to Be Prepared and Have All The Knowledge. having no idea what's going on and being completely unprepared for any bad things that might pop up is the inverse of that

aesthetic - library books

el

colour - pink

deepest fears - that she's a monster

aesthetic - she doesn't really know who she is yet, so like... idk, some of those bright oufits she wore in season 3?? there were a LOT of hearts scattered around her bedroom in season 4, she seems to really like those <3

mike

colour - blue. including (but not limited to) a blue so deep that it looks black

deepest fears - being unwanted, being rejected for something he can't change about himself. in essence, that he's inherently unlovable

aesthetic - i went for a bike for my aesthetic mike wheeler playlist picture. wheels, wheeler. you get it

will

colour - yellow

deepest fears - oh god. i don't think about him enough for this. considering his two biggest breakdowns so far have been about losing mike, i guess that? the whole thing about being a freak, keeping parts of himself secret, being treated like this fragile little baby (when if anything being a survivor makes him the opposite). i'm not the right person to ask about will tbh

aesthetic - art, drawing, sketchbooks. dungeons and dragons, nintendo, wizard imagery

nancy

colour - purple/pink

deepest fears - maybe just watch her vecna vision sequence again? lol. she's mostly got survivor's guilt and blames herself for not saving barb. she's scared of that happening again, e.g. when she was the first to dive into the lake after steve, because she refuses to do nothing again like when barb got dragged into steve's pool yelling for nancy's help (which fred dying on her watch was an echo of)

aesthetic - my initial, instinctive thought is "girlboss" lol. guns, notebooks (re: investigative journalism). there's a wall of stuff in her room that el looks at in season 1 which might be helpful (i'm thinking of the little photostrip of nancy and barb messing around and laughing like el and max did in season 3)

[faulty-heat-vents]

//Narrative communication established. [ASSIST: COURSE-CORRECT]> RE-ESTABLISHING NARRATIVE TRACE. [your story will continue|it is by grace alone you persist]

No blackouts or double-edged words on the way back. All Ashton has as company during his walk is the mech-shop’s cacophony- so natural that his mind doesn’t even spare it the resources. Instead, it burrows in on itself like a pillbug, looping over and over the visions he saw during his nightmares.

He was right- that gore-painted chassis in space was a Monarch. He hadn’t guessed it was his- or rather, a previous Ashton’s. He also hadn’t guessed about its destruction method.

The dream before was a freeze-frame, looking in. Looking out and seeing a laser shear through reality and pierce your cockpit… he never thought he’d remember it. 

Did he think about remembering it at all? Had the concept of that death ever crossed his mind before he saw it?

He can’t remember.

Thermie’s voice cuts through his mind-haze just as sharply as the Unraveller-

 //[THERMALLY_CHALLENGED]:

Movement suggests Pilot has awakened. Welcome back. You have [0] reply-less messages. You have [ERROR: MISSING VALUE.] unread messages.

You have [2] unopened parcels, both of which contain pastries from Omninet denizens. Both have been cleared by Biohazard and Forensics for consumption, and are located inside of your cold-storage locker.

//CORRESPONDENCE: ASHTON-212:

thanks thermie. omw rn

The message is brief, tapped out on the inside of his bracer while walking. Eyes down, mind drifting. 

His path leads him to the armory. Wrong place.

Wait, Ashton thinks to himself. Indigo told me to investigate my weapons. I left that auto rifle down here. Wonder if…

Sure enough, it was- one GMS T-1 automatic assault rifle, freshly-printed and unattended at the testing tables. Waiting.

Up close, the weapon is massive- easily weighing as much as Ashton himself. Each panel along its side is brutal and simplistic, printed with universal compatibility in mind. Ash slides the breech open with considerable -yet necessary- force, exposing its vacant firing and magwell chambers. 

I shouldn’t be doing this without my armor. Command would skin me alive…

He looks up to the empty range around him-

But one little firing test shouldn’t hurt. It’s a GMS rifle- damn things are perfect out of the box, right?

With a determined chirp, he gets to work- first finding a spare Main mount dummy, then hoisting the weapon onto it and buckling it down. As is typical for its make and model, the gun satisfyingly clicks right into place. 

Whatever-above, bless GMS.

Interfacing with GMS tech is as simple as installing it- a single robust cord with interchangeable male prongs, socketed directly into the firing control of its attached machine. Ashton threads the cable to the testing terminal and begins the booting sequence, quickly jumping up to correct the rifle’s aim downrange before the internals spin up. 

A deep breath, then-

>DISENGAGE SAFETY? Y/N >Y [enter] >AUTOMATIC TARGETING SYSTEMS INITIALIZING. PLEASE WAIT.

…Wait, automatic targeting? That’s not stock sta-

BRRRT

The rifle kicks to life, sending its mount dummy reeling backwards. A volley of rounds sprays from its muzzle like a severed artery. The air reeks of accelerant and burning metal as the assembly twitches in animalistic death-throes.

“SHIT! SHIT SHIT SHIT SHI-”

Ashton lunges from his command post, tackling the wild gun to the ground and yanking its connection cable from the receiver. Horrifically, the weapon keeps firing- exhausting all energy inside of its artificial body to maintain the stream of lead. Ashton flips his pack-ax out of its holster and hacks wildly at the assembly’s vital organs, trying in vain to shut it down. 

Time slows. 

A flash crests the edge of his vision- then weaves its way right in front of his face.

For a single breath, one lone bullet hovers directly between his eyes. In the next, it finds itself buried in the faceplate of the target dummy downrange.

The rifle spits out a burst of ammunition before running dry. It clicks, clicks, clicks- over and over before Ashton drives the axe inside its receiver with both hands, finally dealing a killing blow to the plasteel monstrosity.

----

Ashton can barely hear over the ringing in his unprotected ears. He most certainly doesn’t hear the thudding of boots coming his way, nor the voices of Security yelling at each other. He barely registers the hands on his shoulders before they hoist him aloft.

Commander Oracle storms into the room, diadem and third eye flashing neon green as they scan Ashton’s recent memories.

“CADET G-212, STAND DOWN!” they roar.

“Bit hard to do with these tanks grabbing me by the scruff, Oracle!”

“That’s Commander Oracle to you right now. What in the Sham Hells were you THINKING, Cadet?! Unsanctioned, unprotected firing of an uninspected firearm, alone?!”

Ashton squirms in the Security officers’ grip, to no avail. “I was just checking to see if it was printed right!”

“Like HELL you were- and breaking every protocol in the book while you were at it!” 

Oracle kicks the broken weapon with their boot, sending a thud echoing through the range… tailed by a squelch.

Everyone freezes, then slowly trails their collective heads down. The left guard’s hand shakes and falls from Ash’s arm, leaving him to dangle from the other over the growing puddle.

Leaking from the mangled corpse of the T-1 automatic assault rifle is blood- red, quickly-coagulating blood. The weapon’s exposed, fleshy insides cough up more intermittently as its witnesses stand frozen in horror and disgust.

“It- it wasn’t like that when I killed it,” Ashton stutters. His voice hitches as he tries to hold back his nausea.

The guard to his left breaks their resolve much easier, turning away to be sick. Ashton looks to Oracle, whose face has taken a similar shade of pale green to their dimmed diadem. They swallow back their own unease and get back in character-

“Security, restrict this range. I’m contacting Biohazard and Forensics as we speak. G-212, you’re going to answer my questions with utmost honesty and brevity. No word-dancing. Out, now.”

“Yes, Commander Oracle.”

----

“Then you guys showed up, and now we’re here.”

Ashton crouches beside Oracle, poking at the now-very-dead-and-toasty “gun” with a screwdriver. Oracle places a hand on their chin in thought, then speaks-

“Ashton. You know how this looks.”

“I know, I know.” Ash tosses the screwdriver back into its home pail of tools. “A1 did the same damn thing with that Gorgon.”

“No. You talk like an NHP, pass out, see yourself dying over and over again, and then book it towards your gun filled with flesh. If the rest of the Administration saw this, I’d be fired- and you’d be fired upon.”

Ashton makes a face. “What do you suggest we do, then?”

“...”

“Ori?”

“Field it.”

Ashton wheels on a paw with surprise, jaw wide agape. No words manage to form- just shocked squeaks.

Oracle continues- “You heard me, Cadet. Patch this thing up. See if it works. It did pretty damn good here.”

“What the fuck do you mean?! It went ballistic and shot everywhe-”

“Look.” 

Oracle raises a finger and points at the target downrange. A pair of clean holes are punched through its head and heart, no marks anywhere else. No marks on the walls either. 100% accuracy.

“Take this slag to Ciryn and nurse it back. I’ll talk Biohazard into letting it go. If everything goes to shit on the field, it’s on your head again. Last chance.”

“I… thank you, Oracle.”

“Commander Oracle,” they correct again. “And don’t thank me. I’m sending you into the next deployment with this fucking thing on your mech. Spend that gratitude on safety precautions.”

Not much else to say. Oracle whistles and spins two fingers in the air, motioning for everyone to move out.

Ashton stays behind, seated next to the charred remains of the smartgun. 

Maybe it’s the dim lights of the range. Maybe it’s Oracle’s diadem reflecting the hangar above. Maybe it’s lingering embers.

Or maybe the optic winks at him.