#Systemic scleroderma

[burythecarnival]

well met, majestic tumblrites 🖤 i have been so fucking sick; i am not ignoring anyone! the pain from the arthritis flare, edema flare, inflamed spine & feeling like my tissue & muscles are corroding is making me so tired. my kidneys feel like they were stabbed & i am so fucking nauseous even after max zofran doses.

i need to try to eat, get some groceries & order new arthritis gloves because i have no clue where one of my kitties stashed them 🐈‍⬛

help is not expected but it is immensely appreciated. do not apologize if you cannot help! life is a wretched cock for plenty of people right now 💋

luv, cuddles & cauldron bubbles, the ghost queen 👻

×××××××××××××××××××××××××××××××××××××××××

cashapp: $dryboneslive / venmo: dryboneslive

[disabledsysboxes]

Autoimmune - 3

[ferretly]

So, uh, does anyone here have (systemic) scleroderma? The last post was from a year ago 💀 but I may as well ask.

[dangerdust2]

Increasing evidence shows that SSc is related to various occupational and environmental factors, such as silica exposure .

The risk of SSc in silicosis patients is 28 times higher than that in the general population .

The clinical characteristics of SSc patients with silica exposure are different from those of SSc patients without silica exposure, such as the degree of dermatological disease and of visceral involvement, and the degree and type of autoantibodies 

Key Points

•Concomitant silicosis worsens SSc patients’ prognoses.

•For individuals with occupational exposure, close observation of the symptoms of SSc, early diagnosis, and interruption of exposure may improve the prognosis.

•Gangrene, Scl-70, elevated BNP and cardiac involvement are independent risk factors for overall mortality.

[industrynewsupdates]

A Comprehensive Overview of Systemic Scleroderma Treatment Market Landscape

The global systemic scleroderma treatment market size is expected to reach USD 1.9 billion by 2027, according to a new study by Grand View Research Inc. The market is expected to expand at a CAGR of 4.0% from 2020 to 2027. The market is largely attributable to the strong presence of therapies used off-label that include small molecule therapies including branded, generics, and OTC drugs.

The mix of several indications and drug classes engenders a fragmented space with multiple players. Johnson and Johnson Services, Inc. dominated the market with a share of 23.7% in the year 2019. United Therapeutics Corporation is the second biggest service provider in the space with a significant share in 2019. The other players such as F. Hoffmann-La Roche Ltd., Gilead Sciences Inc., GlaxoSmithKline plc, Novartis AG, and Pfizer Inc. also have a significant share of the global market.

The on-label treatment is in the development phase. Major players with therapies undergoing clinical development are divided into two sorts. There are some developing new compounds, whereas certain other established players are seen repurposing their drugs (currently approved for other indications) for scleroderma use. In September 2019, Boehringer Ingelheim GmbH announced the U.S. FDA approval of Ofev for the treatment of interstitial lung disease in patients with systemic sclerosis.

Supplemental indication approval is one of the most common strategies adopted by pharmaceutical players thriving in the space. There are several pharmaceutical companies adopting strategies that favor the pharmaceutical industry in offsetting high development costs.

Gather more insights about the market drivers, restrains and growth of the Systemic Scleroderma Treatment Market

Systemic Scleroderma Treatment Market Report Highlights

• The immunosuppressors segment held the largest revenue share in 2019, followed by prostacyclin analogues

• The high preference for immunosuppressants owing to the favorable reimbursement scenario associated with this drug class will support its dominant share in this space

• The U.S. held the majority of the revenue share in 2019. Expected label expansions and the expected launch of first-in-class therapies coupled with an evolving reimbursement landscape for orphan drugs are expected to support market growth

• Europe trails with a lower share as compared to the U.S. majorly due to higher use of generics and biosimilars for off-label treatment of scleroderma

Systemic Scleroderma Treatment Market Segmentation

Grand View Research has segmented the global systemic scleroderma treatment market based on drug class and region:

Systemic Scleroderma Treatment Drug Class Outlook (Revenue, USD Million, 2016 - 2027)

• Immunosuppressors

• Phosphodiesterase 5 inhibitors - PHA

• Endothelin Receptor Antagonists

• Prostacyclin Analogues

• Calcium Channel Blockers

• Others

Systemic Scleroderma Treatment Regional Outlook (Revenue, USD Million, 2016 - 2027)

• North America

o U.S.

o Canada

• Europe

o Germany

o U.K.

o France

o Italy

o Spain

• Asia Pacific

o China

o Japan

o India

o Australia

• Latin America

o Brazil

o Argentina

o Mexico

• MEA

o South Africa

o Saudi Arabia

o UAE

Order a free sample PDF of the Systemic Scleroderma Treatment Market Intelligence Study, published by Grand View Research.

[dangerdust]

Silica associated systemic sclerosis: an occupational health hazard

A middle-aged male working in the sandblasting and stone-cutting industry was brought to the medicine department with skin tightness, dysphagia and discolouration of the skin for the last 1 year.

On examination, he had skin thickening over the face and the extremities with restricted mouth opening. His hands were cold and showed peripheral cyanosis. Systemic examination was suggestive of diffuse cutaneous systemic sclerosis, further confirmed by the antinuclear antibody testing.

Further, CT of the chest showed mediastinal lymphadenopathy with eggshell calcification and interstitial fibrosis consistent with silicosis and fibrotic non-specific interstitial pneumonitis. 

[cannabiscomrade]

It's Gastroparesis Awareness Month

Hi! I have gastroparesis and I'm an insufferable know-it-all so let's talk about it!

Gastroparesis, or a paralyzed stomach, is a condition that causes delayed gastric emptying.

This can cause a range of symptoms and complications:

nausea

vomiting

early satiety/fullness

upper gastric pain

heartburn

malabsorption

dehydration

malnutrition

Gastroparesis can be treated by a gastroenterologist, but often needs to be managed by a motility specialist due to a lot of misconceptions about the condition. Providers, especially in the emergency department, will commonly misdiagnose gastroparesis as cannabis-hyperemesis syndome, cyclic vomiting syndrome, gastritis, food poisoning, etc.

There are several commonly known causes of gastroparesis like vagus nerve damage from diabetes, injury to the stomach, and stomach surgery like hernia repair or bariatric surgery. There are also idiopathic cases with no known cause. Other causes of gastroparesis are:

Connective tissue disorders like HSD and EDS (commonly hEDS and cEDS)

Post-viral (like COVID, viral gastritis, mononucleosis/Epstein-Barr)

Restrictive eating disorders

Autoimmune diseases like Systemic sclerosis (scleroderma), Lupus, Hashimoto's

Central nervous system disorders

Gastroparesis also has common comorbidities with conditions like:

POTS and other forms of dysautonomia (POTS, EDS, and gastroparesis are a common triad of diagnoses)

MCAS

SMAS (which can also present with similar symptoms to GP)

Intestinal dysmotility and esophageal dysmotility disorders (known as global dysmotility)

PCOS with insulin resistance

Endometriosis

SIBO/SIFO

Chronic intestinal pseudo-obstruction

Migraines

Certain medications like Ozempic and other drugs in that class act on the digestive system to delay gastric emptying, which has caused people to be diagnosed with gastroparesis. Some people report that their cases have not gone away since stopping the medication, others report feeling better after stopping. Other drugs like opiates and narcotics can cause delayed gastric and intestinal motility as well, but these are commonly known side effects of those painkiller classes.

Gastroparesis is classed based on severity and graded based on how you respond to treatment.

Severity of delay ranges from mild to very severe, and this is based on your actual stomach retention calculated at 4 hours into a gastric emptying study.

The grading scale ranges from one to three, one being mild and three being gastric failure.

There is no consistent single treatment that is proven to work for gastroparesis, and there is no cure. Treatments can consist of:

Diet changes (3 Step Gastroparesis Diet, liquid diet, oral sole source nutrition)

Prokinetic (motility stimulating) drugs

Anti-nausea medications

Proton-pump inhibitors

Gastric stimulator/gastric pacemaker

Pyloric botox and dilation

G-POEM/pyloroplasty

Post-pyloric tube feeding

Gastric venting/draining

Parenteral nutrition

IV fluids

Other surgical interventions like gastrectomy or rarely, transplant

Gastroparesis is a terrible disease and I hope that if any of these symptoms resonate with you that you can get checked out. I was misdiagnosed for a long time before getting a proper gastroparesis diagnosis, and all it took was a gastric emptying study. This is ESPECIALLY true if you're having post-COVID gastrointestinal problems that are not improving. I almost died from starvation ketoacidosis because of how serious my GP got in a short period of time post-COVID (I had GP before COVID), and now I'm tube reliant for all my nutrition and hydration.

Stay safe friends!

[doomedfromthewombfr]

Hey there. Welcome to my blog- my little corner of the universe. I’m Ember, here to serve up a blend of existential dread, mental illness chronicles, and dark humor that somehow makes sense of the chaos.

If you’re looking for a ‘how-to’ on inner peace or any version of “good vibes only,” you might want to hit that back button. Here, I am all about raw honesty and laughing at life’s absurdities, like navigating a long list of diagnoses, trying to trick my brain into caring, and figuring out if I even exist outside my home. Basically, it’s all the stuff no one really wants to talk about… but probably should.

So grab a snack, settle in, and let’s take this weird journey together. I’m not here to be fixed; just here to feel a little less alone in the mess.

You can ask me anything 🖤

Side blog for my daily life and struggles- a bit more personal: https://www.tumblr.com/obsidianwhipsers/769545712780345344/welcome-to-the-mess-my-name-is-ember-this-is

Chronically ill and permanently disabled

Professionally diagnosed with:

~Borderline Personality Disorder

~CPTSD

~GAD

~Panic disorder

~Agoraphobia

~OCD with Contamination and magical thinking

~Bipolar 2

I also have many chronic physical health conditions/diseases *actually diagnosed*- Fibromyalgia, Sjogrens, Systemic Scleroderma, POTs, inappropriate sinus tachycardia, degenerative disc disease, arthritis, narrow angle glaucoma, migraines, ocular migraines, endometriosis, chronic fatigue syndrome (ME/CFS), adult onset asthma.

*in process of getting diagnosed with or ruling out MS- a lot of brain lesions (T2 Flairs)- could also be Neuro Sjogrens (NSS)

[otakusheep15]

Hey, sorry if your requests are full, and don't bother if you don't want to do it. But, I have four autoimmune conditions, and I'm wondering if you can make the Obey Me brothers (and any others you want) react to them. I have arthritis, which, for me, means the cartilage between my joints swells, causing pain, especially when it rains, snows, etc. I also have Ehlers-Danlos syndrome, which is hyper flexibility (that with my arthritis means my joints pop out of place a lot), and I have localized scleroderma which means "hardening of the skin" and anywhere I get hurt has a chance of becoming a scleroderma spot which is where my immune system attacks the muscle underneath it, causing silvery bruised areas that dent in and i scar super easily. I have one big one right over my shoulder blade. And finally I have multi-connective-tissue-disease which means I have symptoms of other autoimmune conditions, the most noticeable one if occasionally my lungs try to fill with fluid (not bad enough that I can't breath, but enough that my lungs feel half the size). I got all of these diagnoses between the ages of 10 and 14. If you want to only do one or two of these, it'll be fine, but I haven't been able to find anything remotely close to this in someone else's posts. I do have a high pain tolerance, so I can still do almost anything others can do (except the monkey bars 🥲), and I walk with a cane on bad days. Stress does make my conditions worse. (Also, Mammon and Levi are my faves, and I like Asmo less.) Thanks a lot if you decide to do this! 😊

Of course, I can absolutely do this! I'm not the most familiar with autoimmune conditions, so a lot of what I mention is coming from google research and outside sources. If anything sounds incorrect, please let me know so I can fix it!

Also, so that this can relate to as many people as possible, I'm going to try and keep the specifics vague. I hope that's alright!

So, first things first: the Devildom is not exactly the most accommodating for you. It's unfortunate but it's true. If you need anything specific, you need to let someone (like Lucifer, Barbatos, or Diavolo) know so that they can better help you during your stay. Otherwise, you'll pretty much be on your own.

The first couple of weeks are a struggle. As you're getting to know everyone, not many of them are willing to help you immediately. As you make pacts and form bonds, they're more willing to understand your condition(s) and help you out, but it takes a while.

Getting around the Devildom is probably your biggest struggle, especially if you use any sort of mobility aid, or if you're less physically capable. Everything was built with demons in mind, and demons are already more advanced than the average human, so you can imagine how someone with your condition(s) might fare.

Luckily, you have all of the Devildom's most powerful demons on your side, and they're more than happy to help you once you've made connections. If there's a long set of stairs you can't get up, Mammon or Beel will absolutely carry you. If you need to take a break and catch your breath, Levi and Belphie will stick with you so you don't feel lonely. If someone is making fun of you or bullying you, Asmo, Lucifer, and Satan are all ready to throw hands on your behalf.

You also (somewhat accidentally) help bring about a lot of change to the Devildom. Diavolo sees how often you struggle to get around, what with all of the demon-centric architecture, and decides that it needs to change, especially if he wants to better relations with humans. He makes a lot of areas more accessible to those with mobility aids, and he also makes sure to place more rest stops (such as benches) around places that didn't previously have many places to rest. He also introduces more education on autoimmunity into RAD so that more demons can know about all the different types of conditions a human can have.

If you're having a bad pain day, your favorite brother is by your side the entire time, tending to your every need. Since the request mentioned Levi and Mammon, I'll use them as examples.

Mammon is lowkey worrying over you if you're having a bad pain day, but he's doing his best. Most of his day is spent grabbing things around the house for you. He brings you water, cooks you food, and finds sources of entertainment for you. If you have any sort of ointments or creams applied to your skin, he's very gentle with you as he helps you. He's also good at massages if you think it'll help you. If you desperately need to go somewhere, he is picking you up and carrying you there himself.

Levi is surprisingly good at taking care of you. He originally wanted to keep you in his room, but he realized his bathtub might not be comfortable to you while you're in pain, so he stays in your room. He brings plenty of snacks and drinks, as well as games and anime to keep you entertained. Most of your time is spent cuddling in bed while watching comfort anime. He does worry about accidentally making your pain worse somehow, but he does his best.

Overall, having any sort of autoimmune condition will definitely be a struggle during your time in the Devildom, but it gets better as you spend time there. You have a great support system of demons ready at your beck and call, all more than willing to take care of you.

[burythecarnival]

well met, beautiful tumblrites 🖤 my pain is at a 9 today & i am having a really fucking hard time. if anyone is able to help me with groceries, some epsom salts, easily heated up meals, snackies etc. for the weekend (please only give if you can afford it & it won't stress your wallet), it would be incredibly appreciated. i am trying to stay bundled up, medicated & as close to comfortable as i can get. i know money is tight for some of you; never apologize if you are unable to help!!

luv, cuddles & cauldron bubbles, the ghost queen 👻

××××××××××××××××××××××××××××××××××××××××××

cashapp: $dryboneslive / venmo: dryboneslive

paypal: message me for email

[does-truth-matter]

The CDC has quietly changed who should AVOID the MMR vaccine.

https://www.cdc.gov/vaccines/vpd/mmr/public/index.html

They now state that ANYONE that “Has a parent, brother or sister with a history of immune system problems” should AVOID THE MMR VACCINE!

What exactly is an 'immune system problem?" Every autoimmune disorder.

* Achalasia

* Addison’s disease

* Adult Still's disease

* Agammaglobulinemia

* Alopecia areata

* Amyloidosis

* Amyotrophic lateral sclerosis (Lou Gehrigs)

* Ankylosing spondylitis

* Anti-GBM/Anti-TBM nephritis

* Antiphospholipid syndrome

* Autoimmune angioedema

* Autoimmune dysautonomia

* Autoimmune encephalomyelitis

* Autoimmune hepatitis

* Autoimmune inner ear disease (AIED)

* Autoimmune myocarditis

* Autoimmune oophoritis

* Autoimmune orchitis

* Autoimmune pancreatitis

* Autoimmune retinopathy

* Autoimmune urticaria

* Axonal & neuronal neuropathy (AMAN)

* Baló disease

* Behcet’s disease

* Benign mucosal pemphigoid

* Bullous pemphigoid

* Castleman disease (CD)

* Celiac disease

* Chagas disease

* Chronic inflammatory demyelinating polyneuropathy (CIDP)

* Chronic recurrent multifocal osteomyelitis (CRMO)

* Churg-Strauss Syndrome (CSS) or Eosinophilic Granulomatosis (EGPA)

* Cicatricial pemphigoid

* Cogan’s syndrome

* Cold agglutinin disease

* Congenital heart block

* Coxsackie myocarditis

* CREST syndrome

* Crohn’s disease

* Dermatitis herpetiformis

* Dermatomyositis

* Devic’s disease (neuromyelitis optica)

* Discoid lupus

* Dressler’s syndrome

* Endometriosis

* Eosinophilic esophagitis (EoE)

* Eosinophilic fasciitis

* Erythema nodosum

* Essential mixed cryoglobulinemia

* Evans syndrome

* Fibromyalgia

* Fibrosing alveolitis

* Giant cell arteritis (temporal arteritis)

* Giant cell myocarditis

* Glomerulonephritis

* Goodpasture’s syndrome

* Granulomatosis with Polyangiitis

* Graves’ disease

* Guillain-Barre syndrome

* Hashimoto’s thyroiditis

* Hemolytic anemia

* Henoch-Schonlein purpura (HSP)

* Herpes gestationis or pemphigoid gestationis (PG)

* Hidradenitis Suppurativa (HS) (Acne Inversa)

* Hypogammalglobulinemia

* IgA Nephropathy

* IgG4-related sclerosing disease

* Immune thrombocytopenic purpura (ITP)

* Inclusion body myositis (IBM)

* Interstitial cystitis (IC)

* Juvenile arthritis

* Juvenile diabetes (Type 1 diabetes)

* Juvenile myositis (JM)

* Kawasaki disease

* Lambert-Eaton syndrome

* Leukocytoclastic vasculitis

* Lichen planus

* Lichen sclerosus

* Ligneous conjunctivitis

* Linear IgA disease (LAD)

* Lupus

* Lyme disease chronic

* Meniere’s disease

* Microscopic polyangiitis (MPA)

* Mixed connective tissue disease (MCTD)

* Mooren’s ulcer

* Mucha-Habermann disease

* Multifocal Motor Neuropathy (MMN) or MMNCB

* Multiple sclerosis

* Myasthenia gravis

* Myositis

* Narcolepsy

* Neonatal Lupus

* Neuromyelitis optica

* Neutropenia

* Ocular cicatricial pemphigoid

* Optic neuritis

* Palindromic rheumatism (PR)

* PANDAS

* Parkinson's disease

* Paraneoplastic cerebellar degeneration (PCD)

* Paroxysmal nocturnal hemoglobinuria (PNH)

* Parry Romberg syndrome

* Pars planitis (peripheral uveitis)

* Parsonage-Turner syndrome

* Pemphigus

* Peripheral neuropathy

* Perivenous encephalomyelitis

* Pernicious anemia (PA)

* POEMS syndrome

* Polyarteritis nodosa

* Polyglandular syndromes type I, II, III

* Polymyalgia rheumatica

* Polymyositis

* Postmyocardial infarction syndrome

* Postpericardiotomy syndrome

* Primary biliary cirrhosis

* Primary sclerosing cholangitis

* Progesterone dermatitis

* Psoriasis

* Psoriatic arthritis

* Pure red cell aplasia (PRCA)

* Pyoderma gangrenosum

* Raynaud’s phenomenon

* Reactive Arthritis

* Reflex sympathetic dystrophy

* Relapsing polychondritis

* Restless legs syndrome (RLS)

* Retroperitoneal fibrosis

* Rheumatic fever

* Rheumatoid arthritis

* Sarcoidosis

* Schmidt syndrome

* Scleritis

* Scleroderma

* Sjögren’s syndrome

* Sperm & testicular autoimmunity

* Stiff person syndrome (SPS)

* Subacute bacterial endocarditis (SBE)

* Susac’s syndrome

* Sympathetic ophthalmia (SO)

* Takayasu’s arteritis

* Temporal arteritis/Giant cell arteritis

* Thrombocytopenic purpura (TTP)

* Tolosa-Hunt syndrome (THS)

* Transverse myelitis

* Type 1 diabetes

* Ulcerative colitis (UC)

* Undifferentiated connective tissue disease (UCTD)

* Uveitis

* Vasculitis

* Vitiligo

* Vogt-Koyanagi-Harada Disease

Wonder how many doctors are paying attention?

~shared from Jodi Wilson

[ferretly]

*

[radfem-polls]

Radfems, do you have any autoimmune diseases?

- No ← pls make this the first option

- Yes, of the endocrine system (Type 1 Diabetes, hyperthyroidism, hypothyroidism, etc.)

- Yes, of the skin (Psoriasis, NS vitiligo, scleroderma, etc)

- Yes, of the digestive system (Coeliac, IBD, etc)

- Yes, of the nervous system (MS, MG, etc)

- Yes, of the joints (Rheumatoid arthritis, etc)

- Yes, fibromyalgia

- Yes, endometriosis

- Yes, lupus

- Multiple of the above

- I have one but it's not listed here

-🐌

[futuremusicstar]

Not that anyone I know is still here… but hi, I’m Jess and I’ll probably never post here again. But I thought I’d give a psa on why.

Turns out the last 6 years of me “loosing weight” was due to an extremely rare autoimmune called myositis… I also have systemic sclerosis (scleroderma) and these two diseases attack my muscle and connective tissue.

I really don’t know how to explain the diseases except that I’ve lost a lot of mobility/range of motion, and muscle mass, but they also tell me it can effect my internal organs and all their connective tissue as well by the fermentation/thickening causing organs to solidify and cease functioning.

Anyway… due to this I haven’t really been on here and may never come back as I navigate my new body and limitations.

Having an invisible disability has sure been rough.

Finding jobs that understand that I can’t do certain things or have to miss days due to treatments or sudden exhaustion where I can’t even get myself out of bed.

And damn I look like I’m anorexic (you don’t wanna see my shoulders) now and all I want is to look normal again.

Anyway, if any of you have questions about me or what’s going or treantments and things i go through, I’ll probably keep this app on my phone for a bit, so message me or if you’re not comfortable asking straight out with your account I’m cool with receiving anonymous asks.