#Holy fucking shit

[historixally-accurate]

hello doogile tag

[spuddragon]

For FUCKING real. My game won't fully load for some goddamn reason, and I'm getting rid of certain mods, trying to figure out what is messing it up. I HAVE HAD NO LUCK SO FAR. I am in loading purgatory right now.

Man, I just wanna play the game...

I hate RimWorld so much, it's the worst game ever created, anyone who plays it is stupid and it shouldn't exist and I hate it and it sucks

Yes alright maybe I'm only saying that because I'm currently going through the 500-600 mods I have downloaded and trying to figure out which of the stupid fuckers is causing the stupid errors I keep getting. Maybe.

[cidthecoatrack-blog]

Y'all, the world is sleeping on what NASA just pulled off with Voyager 1

The probe has been sending gibberish science data back to Earth, and scientists feared it was just the probe finally dying. You know, after working for 50 GODDAMN YEARS and LEAVING THE GODDAMN SOLAR SYSTEM and STILL CHURNING OUT GODDAMN DATA.

So they analyzed the gibberish and realized that in it was a total readout of EVERYTHING ON THE PROBE. Data, the programming, hardware specs and status, everything. They realized that one of the chips was malfunctioning.

So what do you do when your probe is 22 Billion km away and needs a fix? Why, you just REPROGRAM THAT ENTIRE GODDAMN THING. Told it to avoid the bad chip, store the data elsewhere.

Sent the new code on April 18th. Got a response on April 20th - yeah, it's so far away that it took that long just to transmit.

And the probe is working again.

From a programmer's perspective, that may be the most fucking impressive thing I have ever heard.

[sourkreem]

interrupting Jason's saturday afternoon book binge is one way to make him pissy

spot as many easter eggs as you can :>

[the-crooked-library]

hey. what if our souls were so intertwined that time itself twisted - and the fabric of reality ripped itself apart - just to allow us to walk into the next life together hand in hand. what then

[12thhouse-sun]

LASER THIS FUCKS SO HARD

So delighted to be able to finally share my illustration of Death for @bg3tarotdeck. Yes, the Chosen of Myrkul himself, the great and terrible Ketheric Thorm (And Squire!)

The Kickstarter project is complete but you can still late pledge this week if you want a deck. Funding beyond production needs is going to Doctors Without Borders.

[plum-pitt]

GUYS THEYRE MAKING AN OFFICIAL CROSSOVER COMIC. THIS IS NOT A FUCKING DRILL.

ISSUE 13 OF SATURDAY MORNING ADVENTURES DROPPING IN JUNE.

updates below the cut —>

UPDATE #1:

Hiya! since this is blowing up just thought i’d stick this on here. I got this info from a YT community post from teddygamingreview, a smaller channel knee deep in the comics side of the tmnt franchise that i’ve been following for a while. From what i understand this is just teaser/promo material so there’s not a whole lot of other info out yet. Thats all, cowa-fuckin-bunga dudes

UPDATE #2:

TEDDYGAMING REVIEWS CAME IN CLUTCH ONCE AGAIN WITH A BREAKDOWN VIDEO

(Most important new info takeaway that wasn’t already laid out in the previous post, in case you don’t got time to watch right now: the issue after this has some villains from the 2012 series on the cover art, implying that whatever multiverse crossover shenanigans are going on might bleed into he next issue, at least to some extent?)

UPDATE #3:

THIS ONES TOO BIG SO I MADE A SEPARATE POST FOR IT, LINK HERE:

[fwoggiekeromoto]

Time to collect

[blitzwhore]

2x02 Seeing Stars | 2x12 Sinsmas

... Oh.

[reasonsforhope]

"A large clinical trial in South Africa and Uganda has shown that a twice-yearly injection of a new pre-exposure prophylaxis drug gives young women total protection from HIV infection.

The trial tested whether the six-month injection of lenacapavir would provide better protection against HIV infection than two other drugs, both daily pills. All three medications are pre-exposure prophylaxis (or PrEP) drugs.

Physician-scientist Linda-Gail Bekker, principal investigator for the South African part of the study, tells Nadine Dreyer what makes this breakthough so significant and what to expect next.

Tell us about the trial and what it set out to achieve

The Purpose 1 trial with 5,000 participants took place at three sites in Uganda and 25 sites in South Africa to test the efficacy of lenacapavir and two other drugs.

Lenacapavir (Len LA) is a fusion capside inhibitor. It interferes with the HIV capsid, a protein shell that protects HIV’s genetic material and enzymes needed for replication. It is administered just under the skin, once every six months.

The randomised controlled trial, sponsored by the drug developers Gilead Sciences, tested several things.

The first was whether a six-monthly injection of lenacapavir was safe and would provide better protection against HIV infection as PrEP for women between the ages of 16 and 25 years than Truvada F/TDF, a daily PrEP pill in wide use that has been available for more than a decade.

Secondly, the trial also tested whether Descovy F/TAF, a newer daily pill, was as effective as F/TDF...

The trial had three arms. Young women were randomly assigned to one of the arms in a 2:2:1 ratio (Len LA: F/TAF oral: F/TDF oral) in a double blinded fashion. This means neither the participants nor the researchers knew which treatment participants were receiving until the clinical trial was over.

In eastern and southern Africa, young women are the population who bear the brunt of new HIV infections. They also find a daily PrEP regimen challenging to maintain, for a number of social and structural reasons.

During the randomised phase of the trial none of the 2,134 women who received lenacapavir contracted HIV. There was 100 percent efficiency.

By comparison, 16 of the 1,068 women (or 1.5%) who took Truvada (F/TDF) and 39 of 2,136 (1.8%) who received Descovy (F/TAF) contracted the HIV virus...

What is the significance of these trials?

This breakthrough gives great hope that we have a proven, highly effective prevention tool to protect people from HIV.

There were 1.3 million new HIV infections globally in the past year. Although that’s fewer than the 2 million infections seen in 2010, it is clear that at this rate we are not going to meet the HIV new infection target that UNAIDS set for 2025 (fewer than 500,000 globally) or potentially even the goal to end Aids by 2030...

For young people, the daily decision to take a pill or use a condom or take a pill at the time of sexual intercourse can be very challenging.

HIV scientists and activists hope that young people may find that having to make this “prevention decision” only twice a year may reduce unpredictability and barriers.

For a young woman who struggles to get to an appointment at a clinic in a town or who can’t keep pills without facing stigma or violence, an injection just twice a year is the option that could keep her free of HIV.

What happens now?

The plan is that the Purpose 1 trial will go on but now in an “open label” phase. This means that study participants will be “unblinded”: they will be told whether they have been in the “injectable” or oral TDF or oral TAF groups.

They will be offered the choice of PrEP they would prefer as the trial continues.

A sister trial is also under way: Purpose 2 is being conducted in a number of regions including some sites in Africa among cisgender men, and transgender and nonbinary people who have sex with men.

It’s important to conduct trials among different groups because we have seen differences in effectiveness. Whether the sex is anal or vaginal is important and may have an impact on effectiveness.

How long until the drug is rolled out?

We have read in a Gilead Sciences press statement that within the next couple of months [from July 2024] the company will submit the dossier with all the results to a number of country regulators, particularly the Ugandan and South African regulators.

The World Health Organization will also review the data and may issue recommendations.

We hope then that this new drug will be adopted into WHO and country guidelines.

We also hope we may begin to see the drug being tested in more studies to understand better how to incorporate it into real world settings.

Price is a critical factor to ensure access and distribution in the public sector where it is badly needed.

Gilead Sciences has said it will offer licences to companies that make generic drugs, which is another critical way to get prices down.

In an ideal world, governments will be able to purchase this affordably and it will be offered to all who want it and need protection against HIV."

-via The Conversation, July 3, 2024

[sapphicfandompirate]

[anpanman95]

“this time, let me do it”

is anyone surprised they delivered? because I’m the fuck not.

[stripedstarsblueflags]

jesus CHRIST can these two make ONE e-sports video that’s not straight up porn

seriously ferrari had NO RIGHT to post this because in this singular clip we have

1) carlos leaning over charles with one hand on the steering wheel platform and the other arm draped over his headrest

2) carlos continuously encouraging and complimenting charles as he concentrates

3) carlos CHECKING IN with charles

4) charles being confident in himself and just preening under the praise

5) carlos mentioning something very specific about why charles is doing so well

6) charles responding with dazed eyes slack jaw softest murmuring voice “carlos…”

7) carlos checking in again “you know what i mean?” and charles’s voice dropping into barely a whisper “yes”

guys we just witnessed carlos accidentally sending charles tumbling headfirst into an absolute ABYSS of subspace and ferrari broadcasted that to the world

[pastafossa]

IT'S HERE

[samdeancest]

can we please talk abt how gabriel would show patrick marvey porn and fanfics RIGHT BEFORE THEY’D GO TO FILM. OH MY GOD.

i will be over analyzing every scene now KNOWING that they were acting with one another WITH THOSE IMAGES/FICS IN THEIR HEADS.

[hell0jon]

prepare for trouble

and make it DOUBLE