#HOLY SHIT THAT WAS A GOOD GAME

[starryluminary]

I completely understand the hatred for Sticker Star now. If the last Paper Mario game I had played was Super Paper Mario when it came out and I had to wait five years for STICKER STAR? I WOULD OF BEEN MAD AS HELL TOO

[b0nelessdoodles]

tfw you're three deep in anchordeep and you get the notif that you're baby has been neglected so you turn into a speedrunner to get home

[reasonsforhope]

"A large clinical trial in South Africa and Uganda has shown that a twice-yearly injection of a new pre-exposure prophylaxis drug gives young women total protection from HIV infection.

The trial tested whether the six-month injection of lenacapavir would provide better protection against HIV infection than two other drugs, both daily pills. All three medications are pre-exposure prophylaxis (or PrEP) drugs.

Physician-scientist Linda-Gail Bekker, principal investigator for the South African part of the study, tells Nadine Dreyer what makes this breakthough so significant and what to expect next.

Tell us about the trial and what it set out to achieve

The Purpose 1 trial with 5,000 participants took place at three sites in Uganda and 25 sites in South Africa to test the efficacy of lenacapavir and two other drugs.

Lenacapavir (Len LA) is a fusion capside inhibitor. It interferes with the HIV capsid, a protein shell that protects HIV’s genetic material and enzymes needed for replication. It is administered just under the skin, once every six months.

The randomised controlled trial, sponsored by the drug developers Gilead Sciences, tested several things.

The first was whether a six-monthly injection of lenacapavir was safe and would provide better protection against HIV infection as PrEP for women between the ages of 16 and 25 years than Truvada F/TDF, a daily PrEP pill in wide use that has been available for more than a decade.

Secondly, the trial also tested whether Descovy F/TAF, a newer daily pill, was as effective as F/TDF...

The trial had three arms. Young women were randomly assigned to one of the arms in a 2:2:1 ratio (Len LA: F/TAF oral: F/TDF oral) in a double blinded fashion. This means neither the participants nor the researchers knew which treatment participants were receiving until the clinical trial was over.

In eastern and southern Africa, young women are the population who bear the brunt of new HIV infections. They also find a daily PrEP regimen challenging to maintain, for a number of social and structural reasons.

During the randomised phase of the trial none of the 2,134 women who received lenacapavir contracted HIV. There was 100 percent efficiency.

By comparison, 16 of the 1,068 women (or 1.5%) who took Truvada (F/TDF) and 39 of 2,136 (1.8%) who received Descovy (F/TAF) contracted the HIV virus...

What is the significance of these trials?

This breakthrough gives great hope that we have a proven, highly effective prevention tool to protect people from HIV.

There were 1.3 million new HIV infections globally in the past year. Although that’s fewer than the 2 million infections seen in 2010, it is clear that at this rate we are not going to meet the HIV new infection target that UNAIDS set for 2025 (fewer than 500,000 globally) or potentially even the goal to end Aids by 2030...

For young people, the daily decision to take a pill or use a condom or take a pill at the time of sexual intercourse can be very challenging.

HIV scientists and activists hope that young people may find that having to make this “prevention decision” only twice a year may reduce unpredictability and barriers.

For a young woman who struggles to get to an appointment at a clinic in a town or who can’t keep pills without facing stigma or violence, an injection just twice a year is the option that could keep her free of HIV.

What happens now?

The plan is that the Purpose 1 trial will go on but now in an “open label” phase. This means that study participants will be “unblinded”: they will be told whether they have been in the “injectable” or oral TDF or oral TAF groups.

They will be offered the choice of PrEP they would prefer as the trial continues.

A sister trial is also under way: Purpose 2 is being conducted in a number of regions including some sites in Africa among cisgender men, and transgender and nonbinary people who have sex with men.

It’s important to conduct trials among different groups because we have seen differences in effectiveness. Whether the sex is anal or vaginal is important and may have an impact on effectiveness.

How long until the drug is rolled out?

We have read in a Gilead Sciences press statement that within the next couple of months [from July 2024] the company will submit the dossier with all the results to a number of country regulators, particularly the Ugandan and South African regulators.

The World Health Organization will also review the data and may issue recommendations.

We hope then that this new drug will be adopted into WHO and country guidelines.

We also hope we may begin to see the drug being tested in more studies to understand better how to incorporate it into real world settings.

Price is a critical factor to ensure access and distribution in the public sector where it is badly needed.

Gilead Sciences has said it will offer licences to companies that make generic drugs, which is another critical way to get prices down.

In an ideal world, governments will be able to purchase this affordably and it will be offered to all who want it and need protection against HIV."

-via The Conversation, July 3, 2024

[askinkiskarma]

I’m fully back in my game of thrones era, and I need to say just one thing

JUST ONE CHANCE ONE CHANCE I BEG YOU

[lunargazing-png]

never going to recover that they took old-man saren with a gun cane who's a cracked biotic user from us. and he had those cunty ass mandible piercings? served. Ate. Left exactly zero crumbs

[viarayy01-blog]

standing ovation

[front-facing-pokemon]

[ashinaisshin]

Alucard’s bat transformation 🦇 Castlevania: Symphony of the Night (1997), dev. Konami

[lovilena]

I’m so late to the AA hype but like holy shit these games are going to be my new personality for the next couple of months.

Anyways, I tried making a sort of movie poster for one of the cases

[hailsatanacab]

Happy Ghouls and Gangs DPxDC Bang event posting week!! Here's what I've been working on for the @dpxdcbigbang 🥰

Summary:

It’s a normal day for Alfred Pennyworth. He spends it taking care of the manor and watching over its inhabitants, just as he does every other day. It’s an exhausting, never-ending task, that he wouldn’t change for the world. But that night, he is confronted by a stranger in his rooms with a copy of every single soul-binding contract he’s signed for the protection of his family. The new Ghost King wants to update his terms and conditions.

Alfred POV, Ghost King Danny, with some Post-Vivisection goodness and only a little (a lot) of blood and gore and medical fun, but that's for later. Not for the squeamish, please check the tags!!

Snippet under the cut!

It’s a normal day for Alfred Pennyworth.

He wakes up early enough to be ready to greet Master Duke with breakfast when he shambles into the kitchen, he cleans, he greets the rest of the manor’s residents when they finally make it downstairs, he cleans, he goes down to the cave to rouse Master Tim from another sleepless night, he cleans.

It’s a quiet day, or as much as one can be when the place he calls home is filled with vigilantes.

He drops off Masters Damian, Tim, and Duke at school and uses the rest of the trip to pick up some groceries for dinner. Coq au vin tonight, he thinks, it’ll be perfect for the changing of the seasons. A mushroom and lentil substitute for Master Damian will do lovely.

The rest of the day is spent preparing the meal and doing a spot of gardening before it’s time for the school run again. He can’t help but smile fondly as he listens to them needle and tease each other, only stepping in when it starts to become too pointed.

Yes, it’s a normal day for Alfred Pennyworth. It’s at night when it all changes.

There’s a ghost waiting for him in his room. 

A soft glow emanates from the creature’s vaguely transparent body and a crisp frost creeps slowly across the floor, sparkling in the darkness like diamonds.

“Mr. Pennyworth?” it says, the voice bouncing off the walls so that it sounds like hundreds of beings instead of one.

Fear squeezes at his heart and the air in the room turns dark and heavy, so that Alfred struggles to breathe. His mouth is dry, his head is swimming, and he’s not entirely sure if he’s going to survive the night.

[justpassingbyoursht]

Yknow when I first saw Chronos i couldn't quite take him seriously bc he's... he's a twink. who gave him that tiny tiny waist and those birthgiving hips? why is he built like that? i expected a giant or something, i mean the big 3 brothers are built ykno their father should be big muscly guy too right?? and then i realized he's got an hourglass shape and. 😶

my bad supergiant u are right. titan of time. hourglass. titan of time? hourglass. checks out ✓ he is hourglass shaped. an hourglass. ⌛that. that is him. titan of time alright. hourglass

but still that tiny waist

[codecicle]

2 HOUR LONG SLMCCL HORROR VIDEO

[skullsemi]

Alright I'll admit I've been obsessed with the pychic bean kid game

It's Psychonauts!

[blanze]

So I play Dislyte pretty regularly and the design for the Poseidon character is just so... IHAD to do it!

The Hades one had to go through a more extreme makeover to make it feel more Nico-esque though (it has a couple subtle design nods to Velinxi's Young Gods AU too!)

This was supposed to be a take on @percico-nicercy-events 's fest btw, Day 5: Undersea Prince Percy and Underworld Prince Nico but yeah, I'm way behind;;

Next up is a 14 panel comic!

[offline-nobody]

me at the start of in stars and time vs me at the end

i think i need therapy lol

[echolepzy]

Seeing other people experiencing ISAT for the first time is so fucking funny because like

Oh!!!! I remember how that felt! Yikes! Anyway keep going pal you’re doing great (silent screaming because It Gets Worse and yet nothing can be said without spoiling it)