#Etc etc cause i have maybe too many
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#aerti#moraghid#Edeleth#Qiu tong x sun jing#Palunetta#bayojeanne#Caitvy#Clexa#Supercorp#Seyloy#uranep#Korrasami#Doropetra#Yuri supremacy ftw#Ashera x Eunie#Etc etc cause i have maybe too many
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I feel so stupid for being this worked up about the graphics still but god I just. Buries face in hands
#i really worked to set aside my worries and reservations towards it#and hope that they meant it when they said they werent gonna alter too much#but then they went and changed existing options rather than adding new ones#so now we got pplwho are unhappy about the changes and complaining and ppl who are happy with the changes and unhappy with the complaining#whats more is looking at some npcs in anamnesis you can clearly see what an upgrade it is with just the resolution hair upgrades etc#and that you wouldnt have had to alter the facial features of npcs and pcs to polish the games look up#its just so disheartening!!!! i dont feel like im playing ieeha anymore#cause his temporary face isnt him but his usual face isnt either now#and thats not even getting into my many alts who look just as fucked up if not more#and i feel bad for having lost so much motivation#like sure maybe i can mod down the line#but i dont want to HAVE to? i dont like using major mods because i usually prefer the vanilla type of look#and i like it when i can play without feeling like im missing a bunch of stuff when mods are down#it just feels so disheartening?#silvi talks#and whines like a little bitch#i hoped that it would just feel weird because its new but no#the more time that passes the more cynical i feel about the changes HDSGJKSLD
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this is how i saw post
#having a quirky time w it#just realised this is nojoke i do actually have mold on my windows maybe that is the cause of my delusions behaviour etc#would make a lot of sense#this is your brain on a crazy amount of substance abuse for too many years nd mold exposure#💽
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right can i just. okay. lesbian is not a genre so im not looking to lump all these shows together. got that out of the way. im also not looking to pit queer people against each other so ok checking that off the list. i am however going to go ahead and throw the misogyny card out here because it’s fucking annoying how shows that center women, especially when theyre woc and/or queer, still just don’t take off even in progressive online spaces the way any shows with our darling young gay male couples will. i’m not saying that’s, like, the Cause of them being cancelled either because we’ve been shown numbers don’t matter. and many of the “”lesbian”” shows that have been cancelled were popular otherwise. just complaining xo!
#because well maybe many of these lesbian shows are not that good. and it's hard for people to care#but also sometimes they like are. or they're not 'good' but they're still fun and if the dynamics in play were primarily#attractive young guys i personally think they'd take off. but there's no way to like prove that so im just talking out of my ass#and ALSO. regardless of the lesbian aspect of it. many of you will watch such ass shows that have like no women or one woman in it#and hype it up to all hell cause that's your babygirl#I SHOULD BE ALLOWED TO HAVE A GOOFY STUPID ASS DYKE TRAPPED IN A SHOW THAT ISNT THAT GOOD AND HAVE FUN!!!#i deserve pathetic women!!!!!#and also. largely upset with the most recent cancellations because of the butches/masc lesbians involved#because that you know has a special place in my heart. okay whatever#anyway. let me also add that plenty of the people who hype up mediocre gay shows are some of the most annoying people on the planet#so yk maybe it's a gift in a way to just have the illusion that the relationship begins and ends with me and my tv and one friend#but. like. the thing is is some of the tropes/dynamics/etc i see on these shows would make people go ferallllll if u know......#circumstances were different. but they just dont care. and also like. i think it's fair to be sad that ur just not getting more time#with characters u enjoy#that none of the money these streaming services get goes to even shitty quality stuff#honestly it's so smart of them to be like Ooo look gay people i have smth for u! and then get everyone online going#omg stream it so it doesnt get cancelled!!!!!! to maximize off it anyway. and then cancel before it can threaten their image or anything#and get too big. or be smth they invest in
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what if instead of messaging me in the middle of the night about your stupid fucking girlfriend and your stupid fucking problems with her you actually act like my fucking friend and message me like how you message everyone else in our group
#bye ignore my venting bigger problems what fucking ever#im sick of her ass she only messages us for us to help her with her fucking girlfriend problems like we arent even friends atthis fckn point#and i love her shes so funny whatever but god shes literally the worst because i just want to be friends i dont fucking care ab her goddamn#selfish ass gf thats shes obsessed with. be obsessed tell me about it but cant we be friends ab other stuff too#we used to be her 'favorite friend' cause we shared so many interests and we hung around what fucking ever but fuck that right#get a gf and just use us to help better yalls relationship without even telling her you're sharing her private msgs w us huh yeah sure#what fucking ever im so done with this bitch and i cant even get my contacts out cause i have long nails and im js poking my eye#AND SHE WOULD NEVER BE SORRY if our friendship fell apart she would tell everyone i was jealous of her gf or what ever i literally dont care#she was like an older sister before i dont get why getting a gf would have to change shit like ok good for u but what ab us#what about me its not even fucking fair like is it that hard to keep up w ur friends?? NO its fucking not#taking me so long to write a post bc im still fucking helping her with her stupid dumb selfish idiotic gf omfg#just BREAK UP i literally dont fucking care just leave her if she makes u unhappy its literally online tf is she gonna do to u nothing omfg#why am i the one being punished when shes the one with the stupid dumb gf that hates her and herself i dont fucking care i js want m friend#and i cant tell any of our mutual friends cause she dont do that to them its js me so itd be like im being dramatic#and like shit i guess i am but i dont care atp thats all she ever talks to me ab like ok i get it i helped u but stop jfc#but if i said that we'd never talk again bc what fucking ever!!!!!!!!!!!!!!! cause im just dramatic whatever#if u cant resolve these simple problems of communication on ur own then maybe u shouldnt be in a relationship idk js my thoughts! die#sry the 1 person who knows what xactly i mean is asleep and im so tired of getting late night msgs being like hii can u help me SHUT UP#id love to help if we were actually still fucking friends but we arent so js leave me alone bruh#post#nickpost#will delete in morning my mom keeps telling me to put my phone down bt i need 2 say smfh 2 some1#i hate change i hate slight differences in my normal day to day i hate everything i hate not having smth to rely on i hate change i hate it#sry im alg now im js sick of her ass js leave bruh#nimbhe my moms yelling im tired anyway i need to js isolate myself forever no problems if im on an island alone#living my best life in the shade drinking idk water or whatever and just talking to myself bc who even needs friends right!!!!!!!!#its 11:11 make a wjsh#adding more cz whatever im deleting this ltr anyway#its so clear where i stand with everyone cause its always close but not close enough friendly but not friends and i guess its the same w her#bye im out of tags etc whatever nobody matching my freak ever never comfortable in any friendships
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My hot Drakengard take of the day is that after playing it for like 110 hours and counting im very much convinced that ppl who still complain about the gameplay being a "slog" just aren't playing the game correctly. you can hate me for this but you will not change my mind
#gu6chan's musings#drakengard#this isn't to say that it's not FLAWED (looking at you arbalesters...)#but i will say: three allies; seven types of weapons; SIXTY-FIVE WEAPONS IN TOTAL; ALL WITH DIFFERENT WEIGHTS; MAGIC; AFFECTS; ETC#now going back to flaws i will say its perfectly normal and not ridiculously hard to just beat the game without allies/using Caim's Sword#HOWEVER#i see way too many people complaining about this and that enemy being 'frustrating' when it rlly boils down to:#1. use a quicker weapon; or one with a longer range#2. THERE ARE BLOCK AND DODGE BUTTONS?????#the last part in particular x100000000 when you learn to actually block or dodge instead of letting yourself fall on your ass like a silly#little fool and then complain about bad game design the game itself becomes infinitely more playable#ill even argue that drakengards biggest flaw isn't even it's REPETITION (as a matter of fact; that's a strength) so much as the fact it#doesn't encourage/push players to explore and experiment with different weapons and features so much#anyways my advice: long-ranged (preferably fast for the latter!!) weapons for enemies like mages and arbalesters#lightweight weapons for quicker enemies like goblins so you can actually land a hit on them#and for god's sake; the dodge/block button exists for your benefit. use it#ALSO hitting enemies while jumping causes them to fall over and allows you a chance to crack a bit more at them if you have a weaker weapon#works REALLY good with quicker ones too!!!!!#oh AND there's a variation of the dash attack where when you speed up you can do a jump attack for extra points of damage PLUS get them to#fall over like mentioned prior. you can do it with your allies too and its a lot of fun#SPEAKING of allies don't forget them!! ever!!!! (heheh) ESPECIALLY not during later chapters they are there to help!!! let them!!!#uhhhh that should be it... maybe ill make a separate post with these tips but Drakengard is a fun game!! you just have to resist hypnosis!!#(and bad press)
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sooo when are we gonna talk abt the way that fatphobia has srsly fucked up yalls perception of fatness to the point that a lot of yall r calling urselves fat when u really are just not skin and bones bc..... yikes.
#personal#ive seen one too many skinny person calling themselves fat/chunky/overweight/etc#and idk ur weight - i dont want to know ur weight#but also im seeing ppl like smaller than my wife (who is not fat) call themselves fat#and its getting more and more prevalent that im seeing ppl who are objectively thin/average calling themselves fat#and then some of these ppl have the nerve to speak on fatness or say i < 3 fat bitches or whatever but they mean avg size ppl#like idk im not gonna define fatness as One Body Type#and maybe im wrong here and just have a diff definition of fat#but im seeing a lot of ppl with literally flat stomachs or like soft bodies with the smallest amt of body fat calling themselves fat#and then yall will be like oh i love fat bitches and its like someone who has wide ribs and isn't skin and bones#a lot of yall say fat to mean anyone who's bones dont protrude from their skin#and i think I'd be less annoyed abt this if it wasnt for the fact actually fat people get ragged on for existing#and yall wanna pretend u have the same experience bc someone compared you to someone like me once#idk#im just bitchy abt this today esp cause ik so many of yallre gonna ignore this
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well friends I have officially joined the Chronic Pain Club, it’s not great to be here, there’s a chance it’s only temporary but my gut says ‘hmm many doubts’ and I won’t really know for a couple of weeks anyway until my doctors appointment. So. Been navigating that for four days and well we’re navigating at least
#there’s some sort of apollo prophecy dodgeball meme joke here#re me being close to many people w/ chronic pain/illness and being a strong empath#and already using spoon theory periodically for the mental health shite#‘ha ha wow this is so useful I’m glad spoonies consider mental health strugglers part of this too!’ and then I need you to imagine#that very specific TUNK sound a dodgeball makes#those thoughts have been living in my brain this weekend. anyway#mark and di if you happen to see this. TUNK (the dodgeball sound)#maybe it’s more irony than prophecy but as I said the thoughts have been there#I went to urgent care then the er thurs night because I spent an entire workday and over 8 hrs in severe abd pain#and it started on the lower right side so of course worried about appendix/gallbladder/etc#urgent care said yeah go to the er cause no matter what you need diagnostic imaging#and they asked have you ever had ovarian cysts I said no but my mom has (there’s thoughts it can be genetic)#do an ultrasound and sure enough I’ve got em!#and doing some reading up after the fact ‘most are asymptomatic and go away on their own!’ I was like well fuck#I mean that’s great but I’ve already failed the requirements I had STRONG symptoms#ibuprofen didn’t do a thing for the pain. until yesterday the hydrocodone they prescribed was all that would#yesterday experimented with three ibuprofen and that does help thankfully#so yeah needless to say I’m not very optimistic this is a ‘goes away on it’s own’ kinda cyst#but my obgyn is really booked and even squeezing me in/getting me in sooner is two weeks away#which is okay I get it healthcare is a mess#but yeah that means chronic pain for the foreseeable future#¯\_(ツ)_/¯ it is what it is#we’re navigating at least that’s all I can ask for#very glad I have today off because it was a very eventful weekend and I need an additional rest day lmao#but started off with low spoons because didn’t sleep well + pain so we’ll see how today goes#Cassie rambles#chronic pain shite#I have the mental health shite tag. might as well start that one lmao /cries
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having fragmented identifies is weird and annoying. different people enjoy different things and sometimes I'll (or whoever is there, theoretically) will find something I own and I'm like ??? Why the fuck did I buy this? Then donate it or whatever. later on I'll freak out and panic wondering WHERE that object is and it's like, oh xyz got rid of it FUCK
#there are so many main me's its annoying#theres shitty stoner metalhead ripley theres hippie happy tie dye snoopy and folk music ripley then theres scene/mall rat EDM ripley etc#list goes on#too many#i want to crush myself into one cohesively functioning person#i kind of hate having eccentric eclectic interests because im all over the place but i obviously cant rationally explain to people that -#- im not the same person as i was yesterday and maybe tomorrow ill be somebody else who knows#i DO have some concrete people like gloomy and astro and so on but its the MULTITUDE of fragmented Ripley's that gets me#theres teenage ripley theres little young me theres Me Right Now#fighting to exist fighting to be reassured to be forgiven and accepted#shut up ripley#it causes memory issues and communication issues and the varying levels of maturity and comprehension#i sit alone in my room with myself
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Susannah: Yes. Yes, he did risk himself. We all did. A lot of it... OK, a bit half-assed but at least... some of it will stick! You have to try. It's not going to work any more, running for the same old burrows... we're rafting off into space - God! Frank sees it. He said to me one day, 'Suse... you know what's going to do for us all? Not the failure of intellect, moral, muscle - but the failure of imagination! They're all too busy with their snouts in the trough to smell the fire.'
Crystal: Yeah, he says some really daft things.
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Pam Gems, Loving Women (1984)
#100plays#pam gems#loving women#modern drama#theatre quotes#1984#Gems was known best for her adaptations of older works and for her biographical plays (including the phenomenally successful Piaf in 1978)#but she consistently produced original work too‚ tho with less commercial success. this comes from her middle period and is often described#as a comedy about a love triangle; which it is‚ really‚ but that somehow feels like a dismissive way to describe a play that can just as#often raise challenging questions about the nature of activism and social change‚ the complicated way that personal relationships and#polemical discourse can influence one another‚ and the inadequacy of passion alone (both in love and in politics) without a solid#foundation. neatly split into three sections at different points in the characters' lives‚ the first and third might more easily be#described as romantic comedy; the majority of the second scene‚ however‚ is a vicious argument between idealists at odds (or a#revolutionary and a lapsed revolutionary‚ maybe). our three characters are Frank‚ an activist social worker who has recently (at the#beginning of the play) suffered a nervous breakdown‚ his radical coworker and lover Susanne‚ and Crystal‚ the working class hairdresser who#has agreed to nurse Frank in return for a roof over her head. the first scene sets up the love triangle and suggests the disharmony to come#but it is the second scene‚ one year later (and with Frank having left Susanne for Crystal‚ apparently without even breaking up face to#face) (Susannah! sorry not sure why i keep writing Susanne); anyway this is the standout scene‚ a furious showdown between the newly#domesticated Frank and the woman he spurned. there is personal enmity on Susannah's part of course‚ as well as entirely reasonable#frustration at how Frank handled the affair‚ but the argument quickly becomes centred on issues of political dogma‚ his perceived betrayal#of 'the cause' (as well as her) and what he perceives as her naivety and tunnel vision in approaching the work they once shared#it is a shamelessly intellectual segment‚ full of angry‚ verbose tirades on the state of the nation and the futility or necessity of#radical action and subversive agitation‚ sparkling dialogue that demands to be spat with venom (and contrasted completely by a much gentler#meeting between the 2 characters a decade later in the final scene). part of Gem's beauty‚ tho‚ is that she never entirely loses the humour#of the piece‚ allowing for amusing asides like the one above (Crystal enters and leaves several times throughout the argument‚ clearly#uncomfortable with the situation). on the surface it might seem like Crystal is a mildly patronising character‚ unable to keep up with the#idealogical slant of the conversation‚ but as Frank makes clear‚ in many ways she's the most real of the three of them; not having the#privileged middle class background of the others‚ her seeming disinterest in revolution is borne of necessity‚ the necessity of first#staying alive (ie. feeding herself‚ finding a roof to sleep under‚ etc) leaving her little time to engage in the largely theoretical#grandstanding of the two socialists she's fallen in with.
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What I need to be doing: drawing, so that I can maybe attract customers with a snappy advertisement, or perhaps a nice YCH.
What I am Not Doing: Precisely This.
#sketching is relatively okay and all but the minute you ask me to do proper lines I'm screaming crying throwing up etc.#the keyboard drawer is a terrible place to put the tablet clearly. the main table of the desk itself is constantly in the way and it's-#a weird angle to boot due to both the drawer technically being broken and also me sitting offcenter bc of limited ways to arrange the-#desk area to be usable. I am NOT sitting any computer towers in the floor. however laptops are prone to overheating and have less storage-#and thus are much less practical... even if I kind of miss it; and it'd be a better fit for a desk with such a small surface area...#tho if I had one the tablet would still have to be in the drawer anyways; bc the keyboard ensures it doesn't fit on top of the desk#speaking of; they barely fit in the drawer together when I have to shove them both in there. the keyboard is easier to use on top of the-#desk tho; which is why I don't like to keep it in the drawer. the keys on this one especially don't mash good and hurt my fingies#also I HAVE tried the tablet on top of the desk and like. the angle for Literally Everything is just All Wrong; it feels kinda awful to use#in this position even. like. I already have issues getting the tablet to make marks where I want them to; I suspect it could be an age thin#or the pen fell onto the floor too many times lol. or some kind of incompatibility with the replacement cord; which was generic#bc I'm not paying an arm and a leg to wacom for any damn thing when this thing was like. ten dollars. tho I overestimated how long-#it needed to be; which has caused its own host of problems. maybe it's a short then...#cannot remember if this was a problem before the old cord shit out a few years ago or not
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i need a way to get rid of this rage because it will kill me but like how. when the world is Like That. how.
#topic of rage spiral today: child abuse and familial culture in america#like i can vent my rage for hours just walking around talking to myself getting really mad#and it never like. lessens or goes away#i can ignore it but only for very short periods of time because like everything is a trigger for me for anger/despair#i can't interact with my family without having to keep a lid on my simmering anger at the moronic ways we treat each other#and the sheer stupidity of it all#also i can't like avoid my family cause i live here and if my mom thinks i'm not being normal enough (spending toomuch time alone) (etc)#she'll start a fight herself like come ON#and this is just like one category of anger like. i have so many more#and it's compounded by sexism too like im a woman so the responses to my (real. valid.) anger are either social ostracization in an attempt#to make me self-correct my anger#or a show of force to put me in my place#like fuckkkk youuuuuu#when your man gets mad you quiet down and (though you are incapable of being kind) you fawn in ways like increased eye contact and softer#tone of voice. sometimes you even let him leave while still angry instead of beating him down into nothing (though not always!)#and writing all this out does not make me less angry! ignoring it is impossible! I can only briefly distract myself and hope that maybe som#fucking day i'll win the lottery or something and have enough money to move out on my own
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This has evoked so many emotions in me and the prevailing one is a sense of... hauntingness.
We have just started understanding so many things. Not many years ago the only thing we knew about the human brain was that we knew pretty much nothing about the human brain.
We sneer at psychiatric practices and theories from the past but people in the future - possibly a near future, not even a far away one - will look back to our progressive times and be freaked out by what we are doing now, the mental institutions we have, the medication we fill our sick people with.
It's not a bad thing, of course. It means hope. But I also grieve for the lives, the happinesses, the joys and serenities that have been lost and are being lost because discoveries that will be taken from granted later have arrived too late for many.
Story from the Washington Post here, non-paywall version here.
Washington Post stop blocking linksharing and shit challenge.
"The young woman was catatonic, stuck at the nurses’ station — unmoving, unblinking and unknowing of where or who she was.
Her name was April Burrell.
Before she became a patient, April had been an outgoing, straight-A student majoring in accounting at the University of Maryland Eastern Shore. But after a traumatic event when she was 21, April suddenly developed psychosis and became lost in a constant state of visual and auditory hallucinations. The former high school valedictorian could no longer communicate, bathe or take care of herself.
April was diagnosed with a severe form of schizophrenia, an often devastating mental illness that affects approximately 1 percent of the global population and can drastically impair how patients behave and perceive reality.
“She was the first person I ever saw as a patient,” said Sander Markx, director of precision psychiatry at Columbia University, who was still a medical student in 2000 when he first encountered April. “She is, to this day, the sickest patient I’ve ever seen.” ...
It would be nearly two decades before their paths crossed again. But in 2018, another chance encounter led to several medical discoveries...
Markx and his colleagues discovered that although April’s illness was clinically indistinguishable from schizophrenia, she also had lupus, an underlying and treatable autoimmune condition that was attacking her brain.
After months of targeted treatments [for lupus] — and more than two decades trapped in her mind — April woke up.
The awakening of April — and the successful treatment of other people with similar conditions — now stand to transform care for some of psychiatry’s sickest patients, many of whom are languishing in mental institutions.
Researchers working with the New York state mental health-care system have identified about 200 patients with autoimmune diseases, some institutionalized for years, who may be helped by the discovery.
And scientists around the world, including Germany and Britain, are conducting similar research, finding that underlying autoimmune and inflammatory processes may be more common in patients with a variety of psychiatric syndromes than previously believed.
Although the current research probably will help only a small subset of patients, the impact of the work is already beginning to reshape the practice of psychiatry and the way many cases of mental illness are diagnosed and treated.
“These are the forgotten souls,” said Markx. “We’re not just improving the lives of these people, but we’re bringing them back from a place that I didn’t think they could come back from.” ...
Waking up after two decades
The medical team set to work counteracting April’s rampaging immune system and started April on an intensive immunotherapy treatment for neuropsychiatric lupus...
The regimen is grueling, requiring a month-long break between each of the six rounds to allow the immune system to recover. But April started showing signs of improvement almost immediately...
A joyful reunion
“I’ve always wanted my sister to get back to who she was,” Guy Burrell said.
In 2020, April was deemed mentally competent to discharge herself from the psychiatric hospital where she had lived for nearly two decades, and she moved to a rehabilitation center...
Because of visiting restrictions related to covid, the family’s face-to-face reunion with April was delayed until last year. April’s brother, sister-in-law and their kids were finally able to visit her at a rehabilitation center, and the occasion was tearful and joyous.
“When she came in there, you would’ve thought she was a brand-new person,” Guy Burrell said. “She knew all of us, remembered different stuff from back when she was a child.” ...
The family felt as if they’d witnessed a miracle.
“She was hugging me, she was holding my hand,” Guy Burrell said. “You might as well have thrown a parade because we were so happy, because we hadn’t seen her like that in, like, forever.”
“It was like she came home,” Markx said. “We never thought that was possible.”
...After April’s unexpected recovery, the medical team put out an alert to the hospital system to identify any patients with antibody markers for autoimmune disease. A few months later, Anca Askanase, a rheumatologist and director of the Columbia Lupus Center,who had been on April’s treatment team, approached Markx. “I think we found our girl,” she said.
Bringing back Devine
When Devine Cruz was 9, she began to hear voices. At first, the voices fought with one another. But as she grew older, the voices would talk about her, [and over the years, things got worse].
For more than a decade, the young woman moved in and out of hospitals for treatment. Her symptoms included visual and auditory hallucinations, as well as delusions that prevented her from living a normal life.
Devine was eventually diagnosed with schizoaffective disorder, which can result in symptoms of both schizophrenia and bipolar disorder. She also was diagnosed with intellectual disability.
She was on a laundry list of drugs — two antipsychotic medications, lithium, clonazepam, Ativan and benztropine — that came with a litany of side effects but didn’t resolve all her symptoms...
She also had lupus, which she had been diagnosed with when she was about 14, although doctors had never made a connection between the disease and her mental health...
Last August, the medical team prescribed monthly immunosuppressive infusions of corticosteroids and chemotherapy drugs, a regime similar to what April had been given a few years prior. By October, there were already dramatic signs of improvement.
“She was like ‘Yeah, I gotta go,’” Markx said. “‘Like, I’ve been missing out.’”
After several treatments, Devine began developing awareness that the voices in her head were different from real voices, a sign that she was reconnecting with reality. She finished her sixth and final round of infusions in January.
In March, she was well enough to meet with a reporter. “I feel like I’m already better,” Devine said during a conversation in Markx’s office at the New York State Psychiatric Institute, where she was treated. “I feel myself being a person that I was supposed to be my whole entire life.” ...
Her recovery is remarkable for several reasons, her doctors said. The voices and visions have stopped. And she no longer meets the diagnostic criteria for either schizoaffective disorder or intellectual disability, Markx said...
Today, Devine lives with her mother and is leading a more active and engaged life. She helps her mother cook, goes to the grocery store and navigates public transportation to keep her appointments. She is even babysitting her siblings’ young children — listening to music, taking them to the park or watching “Frozen 2” — responsibilities her family never would have entrusted her with before her recovery.
Expanding the search for more patients
While it is likely that only a subset of people diagnosed with schizophrenia and psychotic disorders have an underlying autoimmune condition, Markx and other doctors believe there are probably many more patients whose psychiatric conditions are caused or exacerbated by autoimmune issues...
The cases of April and Devine also helped inspire the development of the SNF Center for Precision Psychiatry and Mental Health at Columbia, which was named for the Stavros Niarchos Foundation, which awarded it a $75 million grant in April. The goal of the center is to develop new treatments based on specific genetic and autoimmune causes of psychiatric illness, said Joseph Gogos, co-director of the SNF Center.
Markx said he has begun care and treatment on about 40 patients since the SNF Center opened. The SNF Center is working with the New York State Office of Mental Health, which oversees one of the largest public mental health systems in America, to conduct whole genome sequencing and autoimmunity screening on inpatients at long-term facilities.
For “the most disabled, the sickest of the sick, even if we can help just a small fraction of them, by doing these detailed analyses, that’s worth something,” said Thomas Smith, chief medical officer for the New York State Office of Mental Health. “You’re helping save someone’s life, get them out of the hospital, have them live in the community, go home.”
Discussions are underway to extend the search to the 20,000 outpatients in the New York state system as well. Serious psychiatric disorders, like schizophrenia, are more likely to be undertreated in underprivileged groups. And autoimmune disorders like lupus disproportionately affect women and people of color with more severity.
Changing psychiatric care
How many people ultimately will be helped by the research remains a subject of debate in the scientific community. But the research has spurred excitement about the potential to better understand what is going on in the brain during serious mental illness...
Emerging research has implicated inflammation and immunological dysfunction as potential players in a variety of neuropsychiatric conditions, including schizophrenia, depression and autism.
“It opens new treatment possibilities to patients that used to be treated very differently,” said Ludger Tebartz van Elst, a professor of psychiatry and psychotherapy at University Medical Clinic Freiburg in Germany.
In one study, published last year in Molecular Psychiatry, Tebartz van Elst and his colleagues identified 91 psychiatric patients with suspected autoimmune diseases, and reported that immunotherapies benefited the majority of them.
Belinda Lennox, head of the psychiatry department at the University of Oxford, is enrolling patients in clinical trials to test the effectiveness of immunotherapy for autoimmune psychosis patients.
As a result of the research, screenings for immunological markers in psychotic patients are already routine in Germany, where psychiatrists regularly collect samples from cerebrospinal fluid.
Markx is also doing similar screening with his patients. He believes highly sensitive and inexpensive blood tests to detect different antibodies should become part of the standard screening protocol for psychosis.
Also on the horizon: more targeted immunotherapy rather than current “sledgehammer approaches” that suppress the immune system on a broad level, said George Yancopoulos, the co-founder and president of the pharmaceutical company Regeneron.
“I think we’re at the dawn of a new era. This is just the beginning,” said Yancopoulos."
-via The Washington Post, June 1, 2023
#call me a half empty glass person#but when progress is made in medicine my heart aches for the ones who came too early#and i don't know why this topic specifically is hitting me so hard#maybe it's because of my brief and thankfully pretty much harmless#but still harrowing encounter with psychiatry#maybe because i have a minor but annoying autoimmune disorder that i finally got the right medication for after years of struggling#now#i wonder if that medication has also been helping with my brain?#i'll never know i guess#but the idea that 'psychiatric' conditions might simply be inflammatory disorders is chilling#why didn't you think of it before?? i'd yell at all the doctors in the world#doesn't it feel obvious that fucked up brain disease is caused by fucking up brain reasons??#schizophrenia is characterized by so many symptoms like fatigue brain fog difficulty with coordination etc#how couldn't you think of treating it like an illness that causes those things#...call me stupid but i just realized this is a triggering topic for me#god i just want people to be healthy and happy is that too much to ask for
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caprice is now a level 6 bard/level 2 monk, with the helldusk gloves that add necrotic damage on unarmed attacks (along with a chance to inflict bleeding), as well as boots that give lightning charge upon dashing, and the jolty vest thing that shocks melee attackers using lightning charges. still dual-wielding hand crossbows for long range combat, and i took the dual wielding perk that increases AC. im dying a lot less partially bc ive learned how to better economize combat actions also.
gave karlach the dual wielding perk to increase her AC, and conversely am having lae'zel use two-handed weapons this time. kinda evens things out that way too, cause lae'zel has the extra action skill so she doesn't really need the offhand weapon attack. astarion kicks ass with the shrieking sword and the AOE saving throw penalty is extemely useful for bard spells.
(side note: the intimidation bonus from the durge origin pairs very well with performance/deception/persuasion bard bonuses.)
OH. something i noticed: caprice can't melee dual-wield with anything larger than shortswords, scimitars, or daggers. i suspect this is connected to being "small" instead of "medium" sized, as astarion does not have this problem and he has the same strength score (8). i don't care either way bc of my focus on unarmed strikes but that's still interesting. edit: wait nvm it's bc i didn't take the dual-wielding perk.
#i still dont really see the utility of a lot of the spells that prompt saving throws and require concentration.#theres so many points of failure and the enemies youd want to immobilize the most#are the ones most resistant to charisma checks wisdom checks etc#also losing an action turn can destroy your party if theres a lot of enemies#tashas hideous laughter is good cause its not limited by enemy type the way hold person and hold beast are#altho i think it requires an intelligence of 5 or above.#newt needs a text post tag#newt plays bg3#at some point in the future i might redo a shiv playthru just to refine his druid battle style#i think i relied a bit too heavily on melee attacks with shiv instead of utilizing cantrips.#even with the circle of spore health buff he did not have the hp to constantly smack enemies with a quarterstaff#maybe i could have taken a lower charisma score and gotten higher wisdom earlier?#dont think multiclassing would have been the way to go for shiv#edit: level 2 monks get a movement speed bonus which is GREAT cause deep gnomes#have a starting movement speed of 7.5m and theres better uses for misty step clothing items
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actually tbfh i do need to rewatch ninjago again soon. its been toooooo long. but i think dr s2 is coming out soon so ill probably wait until after that
#i have so many other thinsg i wanna watch and rewatch too thoooo#its just so easy bc its on netflix#im currently on a brbabcs rewatch tho. so its a while off#i need to finish mml… but i have to watch that Elsewhere so its less convenient that stuff i can watch on my phone etc#i also wanna rewatch adeventure time and mlp. both of which its been YEARS#just bc its been so long. i want to Remmeber….#not toooo fussed abt ninjago tho bc i do find the fandom annoying for the most part 😭 sorry guys im just not 15 anymore i cant relate to you#and i need to rewatch rnm again. lol. but also yeah the anime is out this yr. so maybe thatll last me#im not a huge watcher of stuff actually.#ik ninjago mostly off by heart bc of how insane i was abt it. i had sooo many different accs for it#clip accs and quote accs and shit…#btw my claim to fame is starting the trend of ppl posting ninjago clips wtc. i pioneered that shit#i also transcribed the entire movie bc nobody had done it like 4 years on#lol… so fun. need to reclaim my title of ultimate jay as well. but i fear that will cause Mental Issues again
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I am finally one with S rank
Well for now I am… still have to wait until ranked is actually over lol
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