#Disease 🦠

[xtruss]

HIV Cure Nearer With Way To 'Shock And Kill' Latent Virus

— Published March 27, 2024 | Newsweek

A Stock iIlustration Shows the Human Immunodeficiency Virus. Researchers May Have Found a Way to Remove Latent HIV From Cells, According to a New Study. IStock/Getty Images Plus

We might be a step closer to curing HIV, as researchers have developed a way to knock out a version of the virus lurking in the body.

Using something called an HIV-like particle (HLP)—which are dead HIV particles containing HIV proteins that trigger an immune response in a patient—may help treat the disease, scientists from the University of Western Ontario's Schulich School of Medicine and Dentistry and the U.K.'s University of Bristol reveal in a paper in the journal Emerging Microbes & Infections.

HLP was found to be 100 times more effective at treating the virus in people living with chronic HIV while on combined antiretroviral therapy (cART) than other candidate HIV cure therapeutics.

HIV, or human immunodeficiency virus, attacks the immune system, specifically targeting CD4 cells, which are crucial for helping the body fight infections and diseases. Without treatment, HIV can progress to the more advanced stage called AIDS, which can lead to death in only a few years.

More than 1.2 million people across the U.S. have HIV, with over 30,000 new cases diagnosed every year. There is no cure for HIV, but several treatments are available that can allow patients to live a long life.

HIV is treated primarily with cART, which is a combination of medications designed to suppress the replication of HIV in the body. This therapy works by targeting different stages of the HIV life cycle, preventing the virus from multiplying and reducing its levels in the bloodstream.

The goal of cART is to reduce the viral load (the amount of HIV in the blood) to undetectable levels, allowing the immune system to recover and preventing the progression of HIV to AIDS. However, cART doesn't completely eliminate the virus from the body, and the virus creates a "latent reservoir" where it hides within the cells of the body, lying dormant.

According to the new paper, HLP can help to purge cells of this latent HIV, making it a major step forward in treating and curing the infection.

"The development of this HIV cure was ten years in the making but with strong support from our collaborators in the US, Canada and Uganda, we have observed a striking ability of HLP to drive out the last remnants of HIV-1, which we hope will provide an affordable cure for all," said Eric Arts, the Canada research chair in HIV pathogenesis and viral control at the Schulich school, in a statement.

"To live HIV-free is a goal for the 39 million infected. It is also the priority of the UN and WHO to end the HIV pandemic by 2030," he added.

HLP, a deactivated version of HIV, contains various proteins that make it recognizable to the body as the virus, triggering an immune response. But it doesn't contain any of the structures that make the virus harmful and immunocompromising. HLP can therefore trigger the immune system to go hunting after HIV viruses remaining in the body, including the latent viruses hidden inside the immune cells. This allows the body to "shock and kill" the hidden viruses, the researchers said in the paper.

The researchers used blood samples from 32 patients with chronic HIV from the U.S., Uganda and Canada who had been on stable cART for a median of approximately 13 years. They found that HLP was able to specifically target just the immune cells containing a latent HIV reservoir, removing the virus from the cells.

"Over time, the virus grows more diverse within a single individual that is not on treatment which makes it more difficult to target," co-author Ryan Ho, a master's student at the Schulich school, said in the statement. "This formulation we've crafted covers the theoretical diversity so it can reach the HIV-1 in all those people living with HIV."

This is an extremely exciting discovery for HIV researchers, as it could be combined with cART and one day lead to the total elimination of HIV from the bodies of patients.

Minh Ha Ngo, the paper's lead author and a postdoctoral scholar at the Schulich school, said in the statement: "One concern expressed among people living with HIV for years is that continued use of cART could lead to the virus becoming unreachable and unable to be eliminated.

"The results of this study, by contrast, demonstrate that combining HLP with cART is still able to trigger the latent reservoir, even in chronic cases. If these dormant latent reservoirs can be awakened, then they can be eliminated from the body," Ngo said.

Additionally, HLP appeared to work on all variants of HIV from around the planet, indicating that it could be successful at treating even mutated versions of the virus.

"Owing to its high mutation rate, HIV exhibits remarkable genetic diversity, resulting in different viral subtypes, some of which predominate in particular regions of the globe," said Jamie Mann, a senior lecturer in vaccinology and immunotherapy at the University of Bristol's Veterinary School, in the statement.

"We were excited to see preliminary evidence that our HLP cure therapy reverses latency irrespective of the subtype of the individual's infection. Whilst this needs to be explored further, it hints at the global applicability of our approach," Mann said.

The researchers hope to test this HLP treatment across a larger cohort of people around the world to determine if it is an effective treatment strategy for those with both chronic and acute HIV.

— Jess Thomson is a Newsweek Science Reporter based in London UK 🇬🇧

[dddemigirl]

Wow, I can’t wait for covid 2: electric boogaloo

[pose4photoml]

Having a medical condition that has no cure (hopefully one day) is challenging. As much as I hate having to take an injection every two weeks, I’m so blessed that this medicine is helping me !! I’ve been taking it for 4 months now and I haven’t had to go to the hospital once!!! To make it this far and having less symptoms is amazing!! Who knows maybe remission is possible (fingers crossed 🤞)

[darthteeth]

URGENT!!!Help Abdul Salam Al-Anqar and his family get through this war in Gaza!!!

(URGENT) THEY ARE AT €3,445 OUT OF €50,000 GOAL

I was asked by @nader5555 to make this, if u cannot donate please please share this post. Copy pasted from a message i was sent:

"Only a Few Hours Left Before We Enter Our First Year of War, Genocide, Starvation, and Displacement A Final Plea from the Heart of Hell: Save Us Before Hope Dies 💔🔥 I am Abdel Salam, and I have nothing left but words written by a trembling hand ✍️. The war has not only destroyed our lives; it has taken everything from us. Our home, which was once our refuge, is now a pile of rubble 🏚️.

My car, my only source of livelihood, was destroyed in a sudden strike 🚗, and the work that sustained us is now a distant memory 💼. Today, I live in an endless nightmare. Under a sun that burns everything in its path 🌞🔥, my family and I sit in a worn-out tent, a tent that shields us neither from the summer heat nor the winter cold ❄️. Insects 🦟 invade the place, diseases consume our bodies 🩺, and my younger siblings cry from hunger and thirst 🍞💧. We have no clean water or a crumb of bread to ease our hunger. Each passing day deepens the weight of this hell we live in.

My Daughter Eman is Dying from Malnutrition 😨 My daughter Eman suffers from malnutrition; I have nothing to feed or treat her with. The deterioration of her health is killing me slowly. Every glance in her eyes, every pain she endures, crushes my heart 💔. How can I explain to her that what was once our hope has now turned into nothing but a mirage? The Night Only Adds to Our Pain 🌙 The night does not bring us rest; it only adds to our pain. We sleep on hard ground, feeling the cold in every bone of our bodies 🥶, with nothing but pieces of cardboard 📦 to cover us. My wife Aya cries in silence 🥺 as she watches our daughter’s future fade before her eyes. My mother Eman suffers from illness and needs urgent medical care 🩺💊.

My Father Ahmed is Sick with Cancer and Needs Emergency Treatment My father Ahmed, who is sick with cancer, needs emergency treatment outside Gaza, and the cost of his treatment is at least $10,000, not including accommodation. As he suffers from severe pain, I cannot provide the treatment he needs due to our dire situation.

My Siblings Are in Constant Suffering ⚰️ My brother Omar was unable to continue his studies due to the situation. My brother Nader could not take his high school exams, and my younger brother Mohammad suffers from brittle bones and needs treatment we cannot afford. Every day we live brings us one step closer to the end. Death surrounds us from every side: if not from hunger 🍽️, then from illness 🦠. And if not from illness, then from the despair that devours our souls. Where is Humanity? Where is the World? 🌍💔 We want to leave the devastated Gaza Strip to escape the machinery of destruction and killing and the severity of hunger and poverty. The cost of travel for each person is $5,000, and we are a family of seven members, bringing the total cost to $35,000.

Where are the compassionate hearts? Are you waiting for us to disappear into the depths of this suffering? Are you waiting until death takes us before you act? We are drowning, and we don’t have enough strength to scream for help 🆘. Will you let this cry go unanswered? 😭 Your donation today is our last thread of hope. With the little support I received, I was able to buy a simple phone 📱 to reach out to you. But the bitter truth is that what I and my family need is much greater. We are not asking for much; just enough to save our lives from this hell 🔥. Every donation, no matter how small, could be the difference between life and death for us 👐. Don’t Let Us Disappear in the Darkness of Suffering 🌑 Don’t let our story end here. Be the light that guides us to salvation 🕯️✨.

With every tear, with every pain, I write this final plea to you, Abdel Salam."

taglist

@butchniqabi @xinakwans

@batekush

@appsa

@nerdyqueerr

@butchsunsetshimmer

@biconicfinn @stopmotionguy

@t4tvampireisms

@strangeauthor

@bryoria @shesnake

@legallybrunettedotcom

@lautakwah @sovietunion

@neechees @evillesbianvillain @antibioware

@akajustmerry @dizzymoods

@ree-duh @neptunerings

@explosionshark

@heritageposts

@ibtisams

@schoolteacher

[chloeworships]

The LORD showed me an Egyptian pyramid to confirm what he said about the Egyptian diseases.

The pyramid 🔺looked SUPERNATURAL indeed and had me like where am I? 👀

He also said “deadly human flesh disease 🦠”. I believe this is referring to Ebola or some other disease like it, babes. It makes sense when he showed me the new variant/virus cell months ago, it had triangle spores. Be ready.

I know a lot of ppl think I “fearmonger” but naw

Ps. There was already hail in Nevada per the videos I showed you.

[myhotmessandsoccer]

Got to give my daily shout out on how much I hate trumps bitch Vlatko!

[meritss]

MOTHER MONSTER IS FINALLY BACK 🔥

STREAM DISEASE

[taviamoth]

Day 258

🇺🇸⁠ biden admin to proceed with one of the biggest weapons package to israel (worth $18bn) incl. 50 F-15 fighter jets, despite biden promising to stop arms sales if israel invaded Rafah

•⁠ 35 Palestinians killed, 130 wounded in Gaza yesterday

🔻⁠ Hamas claims attack on IOF tank in Rafah, killing its crew + attack on IOF command & control base in north Gaza causing casualties. 2 IOF soldiers seriously injured in south Gaza

•⁠ IOF shot & killed a 15 y/o Palestinian teen in Qalqiliya (West Bank)

🚚 israeli settlers block aid trucks heading to Gaza

🦠 Unknown diseases outbreak in central Gaza, fueled by contaminated water, lack of sanitation, hygiene & rising heat which is unable to be dealt w/ as Al-Aqsa Hospital is barely functioning

•⁠ israeli forces bomb a road south of Gaza City (north) killing 1 & injuring others

•⁠ Intense israeli shelling of central & south Gaza as 2+ women killed & 12 injured in Nuseirat + another attack on Deir el-Balah killed 1+ & injured others

[suppotato123]

Screw Hogwarts Houses (and JK Rowling) tell me what degree you would be taking at a magical university:

Thaumaturgical Artificing- The scientific study and application of magic as it pertains to Alchemy (the creation of of potions) and Arcana (the engineering of magical devices).

Necromantic Studies- A degree for those looking for the most modern and ethical methods of raising the dead.

Arcanic Anthropology- This degree walks students through the history of magical artifacts, how to find them, and their proper uses to aspiring Sorcerers and non-magic users alike.

Linguistic Incantology- The study of the properties of magical languages as well as the characteristics of those languages in general ascertained in order to gain mastery over the magical art of incantation.

Magiphysical Sciences- The study of Humanoid systems, anatomy, and physical health and fitness as it pertains to magical gestures and more physically involved magic systems.

Mystic Virology- The study of magical diseases and curses, their effects on the humanoid form, and the treatments and counterhexes for such magical conditions.

Enchanted Horticulture- A branch of Enchanted agriculture that focuses on cultivation of magical gardens for the purposes of spells, medicine, and consumption.

General Studies- This degree covers the most basic information on various magical studies and provides a great opportunity for students to discover their magical passions and/or complete their prerequisite courses before moving on to a more advanced degree.

[magz]

Palestine news summary from Lets Talk Palestine.

[For more information, links, and ways to help check their LinkTree linktr.ee/letstalkpalestine]

April 22 and April 23, 2024.

April 22. Day 199.

• 54 Palestinians killed, 104 injured in Gaza as Israel commits 6 massacres in the last 24 hours

🏥 283+ bodies found deliberately hidden by Israeli army across 4 mass graves in Nasser Hospital following Israel’s brutal siege

• 3 Palestinians, incl. 19-year-old & elderly woman, shot by IOF as they opened fire on cars on a highway in West Bank

🍞 4 bakeries resume production in north Gaza after 170 days of being inoperable

🔻 Hamas claims strike on group of IOF soldiers & military bulldozer + sniped IOF soldier in north Gaza

🦠 700,000 Palestinians affected by unprecedented spread of infectious diseases in north Gaza

🇺🇸 Universities crackdown + authorize police to arrest dozens of students protesting at Columbia & Yale to divest from companies profiting off the genocide in Gaza; sparking similar protests across US campuses

• Leader of Tulkarem Brigades (local resistance group) resurfaces after claims he was killed during Israel’s 3-day raid of Nur Shams camp in West Bank.

April 23. Day 200.

200 Days of Genocide, Instagram Link.

Day 200 - what happened today in Gaza

‼️ Today marks 200 days of genocide. Over 34,000 Palestinians have been killed with the real number including the thousands missing, buried under rubble, estimated to be over 42,000, including 15,000+ children and 10,000+ women.

🏥 310 bodies uncovered in mass graves at Nasser Hospital; many found handcuffed, shot in the head, wearing prisoner's uniforms, or stripped of their clothes.

• 3 Palestinians killed in Israeli airstrike on residential building in "safe zone" Rafah.

• IOF naval ships attack Gaza's coasts, targeting Deir el-Balah, Nuseirat camp & az-Zawayda.

🚚 310 aid trucks entered Gaza yesterday, the most since Oct 7, but still far below the expected 500 per day.

🏥 Israeli forces turn Gaza’s only specialized cancer hospital into a military base, while only 11/35 hospitals remain partially functioning.

[Magz note: partially functioning hospitals in this case means having basic medical treatment available, medical staff, and being way over capacity unable to treat many of the patients. It has been previously noted that multiple hospitals in Gaza have long since lack anesthesia for example, and have to use basic painkillers like ibuprofen if any.]

• IOF continuously bomb Beit Lahia (north Gaza) after ordering evacuation of 50,000 Palestinians despite nowhere safe to go.

[mad3lyncline]

𝑻𝑬𝑿𝑻𝑺 𝑭𝑹𝑶𝑴 𝑴𝒀 𝑭𝑨𝑴𝑰𝑳𝒀 𝑮𝑹𝑶𝑼𝑷 𝑪𝑯𝑨𝑻 . starters from a variety of real texts that have cursed my family group chat .

[ 𝒔𝒎𝒔 📲 ] i didn't see that [ name ] is holding his junk until after i sent the pic

[ 𝒔𝒎𝒔 📲 ] just ate some fig newtons , the extra long ones

[ 𝒔𝒎𝒔 📲 ] fuck yeah , go give that beer your dick !

[ 𝒔𝒎𝒔 📲 ] maybe he'll let you down quicker if you give him an open mouth kiss

[ 𝒔𝒎𝒔 📲 ] you'll want to keep the gondola operator alive but everyone else is dispensable

[ 𝒔𝒎𝒔 📲 ] we have parked our lard asses under displays for souvenirs and we are both NOT MOVING .

[ 𝒔𝒎𝒔 📲 ] no more mountains you've lost your mountain privileges

[ 𝒔𝒎𝒔 📲 ] we still have our sense of humor , but [ name ] may lose theirs at any moment .

[ 𝒔𝒎𝒔 📲 ] we are safe . we think . no need to worry . i don't think .

[ 𝒔𝒎𝒔 📲 ] it's funny now , but i can feel myself getting a bit cranky .

[ 𝒔𝒎𝒔 📲 ] i'm really sick with icantgotowork disease 🦠 it's rough

[ 𝒔𝒎𝒔 📲 ] have you guys gotten diarrhea yet ?

[ 𝒔𝒎𝒔 📲 ] i hear [ name's ] ex is writing a diss track

[ 𝒔𝒎𝒔 📲 ] okay getting food bird pooped on me

[ 𝒔𝒎𝒔 📲 ] i just ate a cake that said 'happy birthday baby jesus'

[ 𝒔𝒎𝒔 📲 ] the autism is strong today

[ 𝒔𝒎𝒔 📲 ] there will be no butt cakes and please take me off this thread

[ 𝒔𝒎𝒔 📲 ] i'll start growing my pubes !

[ 𝒔𝒎𝒔 📲 ] [ name ] is making us celebrate president's day with a cake

[ 𝒔𝒎𝒔 📲 ] my favorite thing is explaining slang that mom will absolutely hate

[ 𝒔𝒎𝒔 📲 ] their old dog looked like a cigarette

[ 𝒔𝒎𝒔 📲 ] yeah it's really hard being really good looking all the time

[ 𝒔𝒎𝒔 📲 ] i'm about to be that asshole that brings their leftovers on a plane

[ 𝒔𝒎𝒔 📲 ] i have to focus on one weird thing a day or i'll die

[ 𝒔𝒎𝒔 📲 ] congrats bunghole i'm proud of you 🥰

[ 𝒔𝒎𝒔 📲 ] just so you know : penis .

[xtruss]

We're Having A COVID Summer Surge. Should You Get The Updated Vaccines Now?

The FDA Just Approved an Updated Vaccines, and Officials Say Paxlovid is Still Effective in Preventing Severe Cases.

— By Sanjay Mishra | August 22, 2024

A Colorized Ccanning Electron Micrograph of a Cell (Blue) Infected with the Omicron Strain of the SARS-CoV-2 virus (Yellow). Micrograph By National Institute of Allergy and Infectious Diseases (NIAID)/National Institutes Of Health/Science Photo Library

The summer of 2024—the fifth since the COVID-19 pandemic began—is projected to be the biggest summer wave of COVID infections to date.

Since early May, COVID infections have steadily increased in the United States, Europe, Singapore, New Zealand, and Australia. The U.S. Centers for Disease Control and Prevention estimates that COVID-19 infections are currently increasing in 25 states based on data from emergency department visits. However, hospitalizations and deaths from COVID remain at their lowest levels.

Now, the U.S. Food and Drug Administration has approved updated vaccines to protect against current variants of the virus.

This recent surge has been driven mainly by a new group of closely related Covid subvariants, known collectively as "FLiRT."

As the summer winds down, students across the U.S. will return to school. Traditionally, this also coincides with the season of respiratory viruses, such as flu, RSV, and increasingly COVID.

"Not sure what will happen this fall and winter," says Kei Sato, a virologist at the University of Tokyo. While the FLiRT variants are likely to keep evolving after summer, entirely new subvariants cannot be ruled out. "An Omicron-like event” seems to have occurred every year in the fall since 2021, says Sato.

Here's what you need to know about the new variants and the new vaccines.

What Are FLiRT Variants?

The "FLiRT" variant family includes the majority of currently circulating variants, identified with the letters KP, JN, and the variant LB.1.

The unofficial name "FLiRT" is an acronym for a set of mutations on the spike protein of SARS-CoV-2, the virus that causes COVID-19. The virus uses spike protein to bind with ACE2 receptors in our nose and lung cells to cause infection.

All proteins are made up of amino acids that string together like beads. Mutations can change one amino acid to another, thereby altering the behavior of the protein and making the virus more or less infectious, or able to dodge immunity.

The FLiRT subvariant family members are descended from the JN.1 variant that was dominant in the U.S. in early 2024. JN.1 itself was highly unusual because it acquired 41 mutations that differentiated it from Omicron XBB.1.5, which is the variant upon which the current bivalent COVID booster is based.

Should You Get The New Vaccines?

The two updated mRNA vaccines, manufactured by Pfizer-BioNTech and Moderna, target a FLiRT variant called KP.2. Anyone over the age of 12 can get the new shots, as long as they haven't received a booster in the last two months.

“Vaccination continues to be the cornerstone of COVID-19 prevention,” Peter Marks, director of the FDA’s Center for Biologics Evaluation and Research said in a statement.

Another vaccine targeting the variant JN.1 and manufactured by Novovax is also under review and could be approved soon.

Previous research also showed that older vaccines based on XBB.1.5, an earlier subvariant of Omicron, were still effective in preventing severe COVID-19. While this vaccine produces antibodies that still target the FLiRT variants, the efficiency is notably reduced. A recent infection from the JN.1 variant also seems to provide strong protection against all the FLiRT variants.

That said, the CDC recommends that everyone six months and older get a COVID vaccine. Those at high risk for serious COVID-19 should get vaccinated with the most recent versions available.

How Alarming Are FLiRT Variants?

Coronaviruses, such as SARS-CoV-2, frequently mutate to avoid recognition by antibodies. The two FLiRT mutations remove the sites on the virus where antibodies bind the SARS-CoV-2 virus.

Additional mutations on the FLiRT variants can either help the virus bind more efficiently to ACE2 receptors making it more infectious, help it evade previous immunity, or both, says Adrian Esterman, an epidemiologist at the University of South Australia, Allied Health & Human Performance in Adelaide, Australia

Early studies show that all existing FLiRT subvariants are very good at dodging previous immunity acquired through multiple COVID vaccinations—including the most recent COVID bivalent booster—or a breakthrough infection from a previous strain of Omicron.

But the good news is that by escaping the antibodies, the FLiRT variants have also seem to lost some ability to infect their target because the virus needed the original antibody-binding sites to bind the ACE2 receptor and enter cells.

"These variants are not yet particularly concerning, even with the new mutations that affect certain aspects of the virus's biology," says Shan-Lu Liu, a virologist at the Ohio State University.

It is common for viruses to acquire mutations that help them dodge immunity, which can affect their ability to infect cells, says Liu. "The viruses can quickly evolve new mutations to restore their infectivity."

But in the meantime, Sato thinks that waning immunity from previous vaccinations and infections, coupled with the FLiRT variant's ability to dodge remaining immunity, are probably the main reason for the recent surge in infections.

Liu also agrees that the currently rising numbers of COVID infections are mostly due to low booster uptake and increased summer travel.

Are COVID Medicines Still Effective?

Emergency department visits, hospitalizations, and deaths have all spiked during this summer but are still much lower compared to earlier waves of the pandemic.

There is no indication that these new FLiRT variants are more dangerous than other Omicron strains.

A study shows that Paxlovid is still effective against FLiRT variants. Other antiviral drugs such as molnupiravir and remdesivir are also expected to work since their mechanism of action is not affected by mutations in the spike protein.

[gallifreyinstituteforlearning]

🤔💀 What methods could permanently kill a Gallifreyan?

Inspired by the legendary Sutekh, the god of death, we explore the rare but very definitive ways a Gallifreyan can meet a permanent end, sans regeneration.

🔋 Artron/Lindos Energy Depletion: Regeneration relies on these energies. If they're depleted or inhibited, they can't regenerate.

🧪 Toxic Substances: Substances like certain acids and human anaesthetics can destroy or inhibit their regenerative ability.

🔫 Energy Weapons: Specific energy weapons can kill a Time Lord outright.

🛡️ Extreme Physical Trauma: Severe physical trauma, particularly to both hearts or the brain, can kill a Time Lord instantly.

☣️ Retro-Genitor Radiation: A weapon specifically designed by the Daleks, retro-genitor radiation inhibits regeneration.

🔥 Extreme Environmental Conditions: Exposure to vacuum or severe radiation can cause regeneration to fail.

🚫 Personal Choice: Time Lords can actively choose not to regenerate.

⏲️ Timing's Everything: Some deaths can just be too quick for the Time Lord to even try and trigger regeneration. It's also possible to permanently kill them if they're attacked midway through a regeneration.

🦠 Viruses and Biodata Corruption: Some diseases cause huge disruption to regenerative processes, including ... Chen-7/One Day Plague (kills binary vascular lifeforms within one day) Abridgement Syndrome (A long-term condition that makes them unable to regenerate) The Dogma Virus (A 'sleeper' virus that stays dormant until regeneration, whereupon the infected Time Lord will become 'zombified') and various other DNA and Biodata corrupting diseases.

We do not accept any responsibility for information from GIL being used to harm any Gallifreyans, no matter how irritating or destructive they might be.

Gallifreyan Biology for Tuesday Wednesday by GIL

Any purple text is educated guesswork or theoretical. More content ... →📫Got a question? | 📚Complete list of Q+A and factoids →😆Jokes |🩻Biology |🗨️Language |🕰️Throwbacks |🤓Facts →🫀Gallifreyan Anatomy and Physiology Guide (pending) →⚕️Gallifreyan Emergency Medicine Guides →📝Source list (WIP) →📜Masterpost If you're finding your happy place in this part of the internet, feel free to buy a coffee to help keep our exhausted human conscious. She works full-time in medicine and is so very tired😴

[mimble-sparklepudding]

FFXIV Screenshot/Gpose Asks: 3.

A few more suggestions for screenshot/gpose requests, in case anyone is looking for inspiration.

Feel free to reblog and I hope you enjoy.

Send 🤖 for a screenshot associated with technology or magitek.

Send ☠️ for a screenshot associated with piracy or the high seas.

Send 💪🏼 for a screenshot associated with strength or power.

Send 💋 for a screenshot associated with seduction or sensuality.

Send 🧳 for a screenshot associated with travel or storage.

Send 🪖 for a screenshot associated with war or conflict.

Send 👙 for a screenshot associated with the beach or swimming.

Send 🐌 for a screenshot associated with slowness or waiting.

Send 🦄 for a screenshot associated with fantasy or whimsy.

Send 🐣 for a screenshot associated with birth or new beginnings.

Send 🕷️ for a screenshot associated with fear or discomfort.

Send 🐍 for a screenshot associated with betrayal or spite.

Send 🦚 for a screenshot associated with pride or performance.

Send 💐 for a screenshot associated with romance or dating.

Send 🌿 for a screenshot associated with plants or nature.

Send 🪸 for a screenshot associated with the underwater world.

Send 🥀 for a screenshot associated with heartbreak or emotional pain.

Send ✨ for a screenshot associated with magic or aether.

Send 🔥 for a screenshot associated with fire or heat.

Send 🌟 for a screenshot associated with fame or renown.

Send 🍻 for a screenshot associated with feasting or carousing.

Send 🥊 for a screenshot associated with sparring or competition.

Send 🏆 for a screenshot associated with victory or triumph.

Send 🎨 for a screenshot associated with art or painting.

Send 🧘🏾‍♀️ for a screenshot associated with meditation or calm.

Send 🎲 for a screenshot associated with luck or gambling.

Send 🏰 for a screenshot associated with castles or walls.

Send 🏔️ for a screenshot associated with mountains or high places.

Send ⏳ for a screenshot associated with time passing or hurrying.

Send ⚖️ or a screenshot associated with justice or fairness.

Send 🏺 for a screenshot associated with history or legend.

Send 🧼 for a screenshot associated with cleanliness or bathing.

Send 🦠 for a screenshot associated with sickness or disease.

Send 🔮 for a screenshot associated with the future or fortune-telling.

Send 🧸 for a screenshot associated with children or childhood.

Send 🪩 for a screenshot associated with parties or dancing.

Send 🎁 for a screenshot associated with gifts or surprises.

Send 📚 for a screenshot associated with reading or research.

Send ❤️‍🔥 for a screenshot associated with lust or sexual attraction.

Send ⚜️ for a screenshot associated with nobility or chivalry.

Send 🃏 for a screenshot associated with humour or comedy.

Send 🎶 for a screenshot associated with music or song.

Send 🖤 for a screenshot associated with secret desires or kinks.

Send 🪚 for a screenshot associated with crafting or building.

Send 🏜️ for a screenshot associated with the desert or wilderness.

Send 🦁 for a screenshot associated with leadership or dominance.

Send ⚫️ for a screenshot associated with grief or regret.

Send 💎 for a screenshot associated with glamour or wealth.

Send 👍🏽 for a screenshot associated with success or approval.

Send 👼🏻 for a screenshot associated with innocence or purity.

Send ❄️ for a screenshot associated with cold or winter.

Send 🗝️ for a screenshot associated with privacy or secrets.

Send 📝 for a screenshot associated with writing or correspondence.

Send 🏳️ for a screenshot associated with surrender or capitulation.

Send 🧞‍♂️for a screenshot associated with wishes or hopes.

Send 🛏️ for a screenshot associated with sleep or resting.

Send 💌 for a screenshot associated with infatuation or crushes.

[animalshowdown]

Phylum Round 2

Arthropoda: Insects, arachnids, crustaceans, and others. The largest and one of the most diverse phyla on Earth, Arthropods have thrived on every continent and ocean, including Antarctica. Their most defining feature is their exoskeleton, which provides both support and protection - Arthropods have developed a number of adaptations to overcome the drawbacks of, as my invertebrate zoology professor liked to say, "living in a vacuum-sealed medieval suit of armor". They possess body segments that have been specialized for their lifestyles, on land or sea. They have relatively complex brains, and many species have shown remarkable cognition. We have had a complicated relationship with Arthropods since the dawn of humanity; they have been critical food sources, disease-carriers and parasites, essential farming partners, and maligned farming pests for thousands of years.

Placozoa: Flat Animals. Described as "the simplest animals on Earth", Placozoans have no specialized tissues or organs, but rather a bundle of several different cell types. They only reproduce asexually, and they are all free-living, non-parasitic. Due to their simple structure, Placozoans are considered to be one of the most primitive animals in the evolutionary tree.

[1mlostnow]

Do I dare drop the vague idea I had for the house md oc?? No…I shan’t

😔🤭🫣🫨

Uhhh did the cut cuz idk how long it’s gonna be.

Stevie “Bird” Corcoran

Bro uses he/him, he’s a home of sexual, DOB 11/02/1978, he’s err uh 5’10, hazel eyes and blonde hair

11/2/1978

His mommy left 😮‍💨

He’s Catholic 🤞

He has 2 sisters and 2 brothers

Grew up in a three bedroom apartment 🙏

He was the second sibling, one more and the next two were twins and then she was like “ok bye”

Forensic scientist often working in PPTH, just kinda hangs around when he’s not busy. He wanted to go into psychology but ultimately decided that if he didn’t like people analyzing and studying him, it wasn’t fair to do it to others. Something about morality. He’s an empath 🤭

Gifted kid -> highschool burnout -> working dream job as an adult

Fucking hates adults that aren’t his friends, loves to work with kids. He’s never been on time for work in his life.

Dresses like a fucking office worker LMAO button ups and ties and shit. Either that or those old man sweaters and yk they all make fun of him for it 😀

Terrible with money, he has had to move in with Chase on two separate occasions.

Autism be damned that boy can’t cook worth a shit 😓

I just know he’s the type to have a secret tumblr and blog about whatever’s going on at the hospital that day “lmao yr mafia? Ok gay boy we know you’re on estrogen anyways 🤣🤣” “can they stop staring at each other like that it’s scaring me…gonna catch gay disease 🦠” “lady came up to me asking about scabs? bitch I’m in forensics idk why you have hemorrhoids but it’s NOT my problem!”

He’s got a daughter, Anna, she’s 12, she read warrior cats. Thats what you need to know. :) I love her, she’s basically Nepeta Leijon :)) the other doctors love her.

I think an important detail about Bird is that he’s always got this happy demeanor and seems like a very sociable person, but a year into opening up to him, you’ll realize he hasn’t told you a single thing about himself.

He doesn’t like to talk much about his childhood but he’s not the type to shy away from it and stay silent, he deflects the question with a smile and a joke.

Fucked around with fireworks as a teen, got that scar :/

Him nd his fuckass mullet

I copied this straight outta my notes app so uhh yeah not gonna bother to edit my little things

Lmk what you think and what else I should add, just put the details I’ve seen others including in theirs :3

I just realized he looks rlly similar to chase in those 😔 his hair is curlier I just couldn’t find any I liked on picrew