#Data Airlines

[trevlad-sounds]

Tuesday 21 November Mixtape 398 “Hidden Place EXCLUSIVE” Ambient Drone Electronic Experimental Space Tuesdays & Saturdays. Support the artists and labels. Don't forget to tip so future shows can bloom.

Trevlad Sounds-Welcome in you wonderful listener 00:00

CV Vision-Error I00II0 00:31

Christian Fiesel-Nothing Left To Say, No Regrets, Just A Quiet Place 00:54

Coda Nautica-Chant 03:23

Sebastian Mullaert, Eitan Reiter-Enter The Spiral 10:13

2xirtam-Time 18:12

arovane-September 25:10

Correlations-AUTUMN SONG 25:55

Benge-Todays ARP2500 31:34

Wojciech Golczewski-The Puppets Dream 34:34

Salvatore Mercatante-l'aqua 38:20

Floresta Oblíqua-Asteroid Paranoid 44:14

Curved Light-Disappearing Through The Passage Of Time 49:43

John Louis Kluck-Fragile Space 52:46

Martin Stürtzer-Trisolar 58:07

Pete Bassman-Wolf Eater 1:06:40

Twenty Three Hanging Trees-Ultime déroute 1:11:25

HAWKSMOOR-Splendor Solis 1:17:05

Cold-Strobe Light Network 1:20:24

Naqada-Hidden Beam 1:35:04

Armand Torrx-Where Mountains Reign 1:44:28

Lyndsie Alguire-stolen kiss 1:46:34

Benn Jordan-Farther Out 1:48:07

The Irresistible Force-Magic Acid 1:49:47

[conceptalbum]

telex from MIDI city.

[savedatateam]

Zinc Leblanc at the finger guns party

[landunderthewave]

Watched a video about these "AI assistants" that Meta has launched with celebrity faces (Kendall Jenner, Snoop Dogg etc.). Somebody speculated/mentioned in the comments that eventually Meta wants to sell assistant apps to companies, but that makes ... no sense.

If they mean in the sense of a glorified search engine that gives you subtly wrong answers half the time and can't do math, sure - not that that's any different than the stuff that already exists (????)

But if they literally mean assistant, that's complete bogus. The bulk of an assistant's job is organizing things - getting stuff purchased, herding a bunch of hard-to-reach people into the same meeting, booking flights and rides, following up on important conversations. Yes, for some of these there's already an app that has automated the process to a degree. But if these processes were sufficiently automated, companies would already have phased out assistant positions. Sticking a well-read chat bot on top of Siri won't solve this.

If I ask my assistant to get me the best flight to New York, I don't want it to succeed 80 % of time and the rest of the time, book me a flight at 2 a.m. or send me to New York, Florida or put me on a flight that's 8 hours longer than necessary. And yes, you can probably optimize an app + chat bot for this specific task so it only fails 2 % of the time. But you cannot optimize a program to be good at everything–booking flights, booking car rentals, organizing catering, welcoming people at the front desk and basically any other request a human could think off. What you're looking for is a human brain and body. Humans can improvise, prioritize, make decisions, and, very importantly, interact freely with the material world. Developing a sufficiently advanced assistant is a pipe dream.

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[r2y9s-notartblog]

getting random bouts of anxiety about an upcoming vacation trip is so crazy. it's a vacation!! ur gonna have fun!!! dw about it!!!! everything will be fine!!!!!

[digital-life-stream]

Harnessing the Power of Generative AI in the Aviation Industry

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[its-vishnu-stuff]

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[jcmarchi]

Epigenomic analysis sheds light on risk factors for ALS

New Post has been published on https://thedigitalinsider.com/epigenomic-analysis-sheds-light-on-risk-factors-for-als/

Epigenomic analysis sheds light on risk factors for ALS

For most patients, it’s unknown exactly what causes amyotrophic lateral sclerosis (ALS), a disease characterized by degeneration of motor neurons that impairs muscle control and eventually leads to death.

Studies have identified certain genes that confer a higher risk of the disease, but scientists believe there are many more genetic risk factors that have yet to be discovered. One reason why these drivers have been hard to find is that some are found in very few patients, making it hard to pick them out without a very large sample of patients. Additionally, some of the risk may be driven by epigenomic factors, rather than mutations in protein-coding genes.

Working with the Answer ALS consortium, a team of MIT researchers has analyzed epigenetic modifications — tags that determine which genes are turned on in a cell — in motor neurons derived from induced pluripotent stem (IPS) cells from 380 ALS patients.

This analysis revealed a strong differential signal associated with a known subtype of ALS, and about 30 locations with modifications that appear to be linked to rates of disease progression in ALS patients. The findings may help scientists develop new treatments that are targeted to patients with certain genetic risk factors.

“If the root causes are different for all these different versions of the disease, the drugs will be very different and the signals in IPS cells will be very different,” says Ernest Fraenkel, the Grover M. Hermann Professor in Health Sciences and Technology in MIT’s Department of Biological Engineering and the senior author of the study. “We may get to a point in a decade or so where we don’t even think of ALS as one disease, where there are drugs that are treating specific types of ALS that only work for one group of patients and not for another.”

MIT postdoc Stanislav Tsitkov is the lead author of the paper, which appears today in Nature Communications.

Finding risk factors

ALS is a rare disease that is estimated to affect about 30,000 people in the United States. One of the challenges in studying the disease is that while genetic variants are believed to account for about 50 percent of ALS risk (with environmental factors making up the rest), most of the variants that contribute to that risk have not been identified.

Similar to Alzheimer’s disease, there may be a large number of genetic variants that can confer risk, but each individual patient may carry only a small number of those. This makes it difficult to identify the risk factors unless scientists have a very large population of patients to analyze.

“Because we expect the disease to be heterogeneous, you need to have large numbers of patients before you can pick up on signals like this. To really be able to classify the subtypes of disease, we’re going to need to look at a lot of people,” Fraenkel says.

About 10 years ago, the Answer ALS consortium began to collect large numbers of patient samples, which could allow for larger-scale studies that might reveal some of the genetic drivers of the disease. From blood samples, researchers can create induced pluripotent stem cells and then induce them to differentiate into motor neurons, the cells most affected by ALS.

“We don’t think all ALS patients are going to be the same, just like all cancers are not the same. And the goal is being able to find drivers of the disease that could be therapeutic targets,” Fraenkel says.

In this study, Fraenkel and his colleagues wanted to see if patient-derived cells could offer any information about molecular differences that are relevant to ALS. They focused on epigenomic modifications, using a method called ATAC-seq to measure chromatin density across the genome of each cell. Chromatin is a complex of DNA and proteins that determines which genes are accessible to be transcribed by the cell, depending on how densely packed the chromatin is.

In data that were collected and analyzed over several years, the researchers did not find any global signal that clearly differentiated the 380 ALS patients in their study from 80 healthy control subjects. However, they did find a strong differential signal associated with a subtype of ALS, characterized by a genetic mutation in the C9orf72 gene.

Additionally, they identified about 30 regions that were associated with slower rates of disease progression in ALS patients. Many of these regions are located near genes related to the cellular inflammatory response; interestingly, several of the identified genes have also been implicated in other neurodegenerative diseases, such as Parkinson’s disease.

“You can use a small number of these epigenomic regions and look at the intensity of the signal there, and predict how quickly someone’s disease will progress. That really validates the hypothesis that the epigenomics can be used as a filter to better understand the contribution of the person’s genome,” Fraenkel says.

“By harnessing the very large number of participant samples and extensive data collected by the Answer ALS Consortium, these studies were able to rigorously test whether the observed changes might be artifacts related to the techniques of sample collection, storage, processing, and analysis, or truly reflective of important biology,” says Lyle Ostrow, an associate professor of neurology at the Lewis Katz School of Medicine at Temple University, who was not involved in the study. “They developed standard ways to control for these variables, to make sure the results can be accurately compared. Such studies are incredibly important for accelerating ALS therapy development, as they will enable data and samples collected from different studies to be analyzed together.”

Targeted drugs

The researchers now hope to further investigate these genomic regions and see how they might drive different aspects of ALS progression in different subsets of patients. This could help scientists develop drugs that might work in different groups of patients, and help them identify which patients should be chosen for clinical trials of those drugs, based on genetic or epigenetic markers.

Last year, the U.S. Food and Drug Administration approved a drug called tofersen, which can be used in ALS patients with a mutation in a gene called SOD1. This drug is very effective for those patients, who make up about 1 percent of the total population of people with ALS. Fraenkel’s hope is that more drugs can be developed for, and tested in, people with other genetic drivers of ALS.

“If you had a drug like tofersen that works for 1 percent of patients and you just gave it to a typical phase two clinical trial, you probably wouldn’t have anybody with that mutation in the trial, and it would’ve failed. And so that drug, which is a lifesaver for people, would never have gotten through,” Fraenkel says.

The MIT team is now using an approach called quantitative trait locus (QTL) analysis to try to identify subgroups of ALS patients whose disease is driven by specific genomic variants.

“We can integrate the genomics, the transcriptomics, and the epigenomics, as a way to find subgroups of ALS patients who have distinct phenotypic signatures from other ALS patients and healthy controls,” Tsitkov says. “We have already found a few potential hits in that direction.”

The research was funded by the Answer ALS program, which is supported by the Robert Packard Center for ALS Research at Johns Hopkins University, Travelers Insurance, ALS Finding a Cure Foundation, Stay Strong Vs. ALS, Answer ALS Foundation, Microsoft, Caterpillar Foundation, American Airlines, Team Gleason, the U.S. National Institutes of Health, Fishman Family Foundation, Aviators Against ALS, AbbVie Foundation, Chan Zuckerberg Initiative, ALS Association, National Football League, F. Prime, M. Armstrong, Bruce Edwards Foundation, the Judith and Jean Pape Adams Charitable Foundation, Muscular Dystrophy Association, Les Turner ALS Foundation, PGA Tour, Gates Ventures, and Bari Lipp Foundation. This work was also supported, in part, by grants from the National Institutes of Health and the MIT-GSK Gertrude B. Elion Research Fellowship Program for Drug Discovery and Disease.

[trevlad-sounds]

Opening track from todays subscription mix.

[igtsolutions]

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[truth4ourfreedom]

THINGS NOT IN THE NEWS ANYMORE. VERSION 6.0

Things not in the news anymore….

(Version 6)

-Maui wildfires. -East Palestine, Ohio -Joe Biden classified documents as a Senator. -Fauci working with China to create a bioweapon. -Pete Buttigieg’s best friend in prison for child porn. -Cocaine in the White House. (TWICE NOW) -The BLM and Antifa riots during 2020 causing BILLIONS of dollars of damage. -The data collected from the Chinese spy balloons. -Ukraine intelligence documents released that showed they were suffering massive losses and the American taxpayer was being lied to. -Nancy Pelosi’s “documentary” film crew on J6. -Veterans being kicked out of shelters to make room for illegals. -Pizzagate “debunker” jailed for possession of child pornography. -Gay porn film in Senate hearing room. -Veterans Affairs prioritizing healthcare of illegals over Veterans. -THE SOUTHERN BORDER CRISIS. -Afghanistan drawdown and 13 service members killed in an attack on Kabul International Airport, that they hid the severity of it. -Obama droning an American citizen in the Middle East. -George Bush’s false WMDs. -3 service members killed in Jordan. -Hunter Biden making over $1M for “paintings”. -J6 political prisoners that are still in jail. -85,000 missing children at the southern border. -Epstein’s clients. -Obama coordinating with John Brennan and 4 other countries (5 eyes) to spy on the 2016 Trump campaign. -Mail-in ballots were the cause of the stolen 2020 election. -Jeffrey Epstein mentioning that Bill Clinton liked his girls “really young”. -The (NOW TWO) airline whistleblowers that mysteriously died. -Benghazi (I won’t mention anything more about this because I care about my life.) -Nancy Pelosi’s daughter stating that January 6th wasn’t an insurrection. -The January 6th committee destroying encrypted evidence before the GOP took over the House. -Nancy Pelosi admitting that J6 was “her responsibility”. -House Speaker Mike Johnson claiming there wouldn’t be foreign aid without border security in the bill, which was a lie. -The recent riots from illegal criminal aliens at the southern border and the border in general. -Hunter Biden not complying with a Congressional subpoena and deemed untouchable. Democrat privilege. -Vaccine side effects. -“Lab leak” out of China -The Secret Service having to basically guide Joe Biden everywhere he goes. -Who leaked (Sotomayor) the SCOTUS Alito decision. -Federal instigators inside the Capitol including pipe bomb evidence against them. -Obama’s chef “passing away”. -HRC’s chef “passing away”. -The Sheriff that happened to be in Las Vegas (during the mass shooting) AND the wildfires in Hawaii. -P Diddy sex-trafficking allegations. Where’s Diddy? -Gonzalo Lira (an American journalist) that was killed in Ukraine -Congress approving warrantless spying violating American’s 4th amendment rights while they are exempt. -Americans that were left in foreign countries (Haiti, Palestine, Afghanistan). -The billions of dollars of weaponry left in Afghanistan and the Taliban receiving $40M a week in “humanitarian assistance”. -Biolabs found in California. -Joe Biden’s impeachment. -The scum in the UNITED STATES HOUSE OF REPRESENTATIVES waving the Ukrainian flag. -The over 300k ballot images that could not be found in Fulton County, Georgia; the same county Donald Trump on trial for “election interference”. -Democrats defunding the police causing massive rises in crime. -Kamala Harris’s record as DA in California. -The Transifesto from the school shooting. -Many U.S. Representatives and Congress receiving FTX funds. -They’re already working hard to bury Donald Trump’s àssassination attempt but we won’t let them bury that story. July 13th is never going away.

The distractions are out of control.

Share to show that legacy media is dead and that WE are the media now.

Please like,share and reblog to keep people aware!

[batboyblog]

Things the Biden-Harris Administration Did This Week #28

July 19-26 2024

The EPA announced the award of $4.3 billion in Climate Pollution Reduction Grants. The grants support community-driven solutions to fight climate change, and accelerate America’s clean energy transition. The grants will go to 25 projects across 30 states, and one tribal community. When combined the projects will reduce greenhouse gas pollution by as much as 971 million metric tons of CO2, roughly the output of 5 million American homes over 25 years. Major projects include $396 million for Pennsylvania’s Department of Environmental Protection as it tries to curb greenhouse gas emissions from industrial production, and $500 million for transportation and freight decarbonization at the ports of Los Angeles and Long Beach.

The Biden-Harris Administration announced a plan to phase out the federal government's use of single use plastics. The plan calls for the federal government to stop using single use plastics in food service operations, events, and packaging by 2027, and from all federal operations by 2035. The US government is the single largest employer in the country and the world’s largest purchaser of goods and services. Its move away from plastics will redefine the global market.

The White House hosted a summit on super pollutants with the goals of better measuring them and dramatically reducing them. Roughly half of today's climate change is caused by so called super pollutants, methane, hydrofluorocarbons (HFCs), and nitrous oxide (N2O). Public-private partnerships between NOAA and United Airlines, The State Department and NASA, and the non-profit Carbon Mapper Coalition will all help collect important data on these pollutants. While private firms announced with the White House plans that by early next year will reduce overall U.S. industrial emissions of nitrous oxide by over 50% from 2020 numbers. The summit also highlighted the EPA's new rule to reduce methane from oil and gas by 80%.

The EPA announced $325 million in grants for climate justice. The Community Change Grants Program, powered by President Biden's Inflation Reduction Act will ultimately bring $2 billion dollars to disadvantaged communities and help them combat climate change. Some of the projects funded in this first round of grant were: $20 million for Midwest Tribal Energy Resources Association, which will help weatherize and energy efficiency upgrade homes for 35 tribes in Michigan, Minnesota, and Wisconsin, $14 million to install onsite wastewater treatment systems throughout 17 Black Belt counties in Alabama, and $14 million to urban forestry, expanding tree canopy in Philadelphia and Pittsburgh.

The Department of Interior approved 3 new solar projects on public land. The 3 projects, two in Nevada and one in Arizona, once finished could generate enough to power 2 million homes. This comes on top of DoI already having beaten its goal of 25 gigawatts of clean energy projects by the end of 2025, in April 2024. This is all part of President Biden’s goal of creating a carbon pollution-free power sector by 2035. 

Treasury Secretary Janet Yellen pledged $667 million to global Pandemic Fund. The fund set up in 2022 seeks to support Pandemic prevention, and readiness in low income nations who can't do it on their own. At the G20 meeting Yellen pushed other nations of the 20 largest economies to double their pledges to the $2 billion dollar fund. Yellen highlighted the importance of the fund by saying "President Biden and I believe that a fully-resourced Pandemic Fund will enable us to better prevent, prepare for, and respond to pandemics – protecting Americans and people around the world from the devastating human and economic costs of infectious disease threats,"

The Departments of the Interior and Commerce today announced a $240 million investment in tribal fisheries in the Pacific Northwest. This is in line with an Executive Order President Biden signed in 2023 during the White House Tribal Nations Summit to mpower Tribal sovereignty and self-determination. An initial $54 million for hatchery maintenance and modernization will be made available for 27 tribes in Alaska, Washington, Oregon, and Idaho. The rest will be invested in longer term fishery projects in the coming years.

The IRS announced that thanks to funding from President Biden's Inflation Reduction Act, it'll be able to digitize much of its operations. This means tax payers will be able to retrieve all their tax related information from one source, including Wage & Income, Account, Record of Account, and Return transcripts, using on-line Individual Online Account.

The IRS also announced that New Jersey will be joining the direct file program in 2025. The direct file program ran as a pilot in 12 states in 2024, allowing tax-payers in those states to file simple tax returns using a free online filing tool directly with the IRS. In 2024 140,000 Americans were able to file this way, they collectively saved $5.6 million in tax preparation fees, claiming $90 million in returns. The average American spends $270 and 13 hours filing their taxes. More than a million people in New Jersey alone will qualify for direct file next year. Oregon opted to join last month. Republicans in Congress lead by Congressmen Adrian Smith of Nebraska and Chuck Edwards of North Carolina have put forward legislation to do away with direct file.

Bonus: American law enforcement arrested co-founder of the Sinaloa Cartel, Ismael "El Mayo" Zambada. El Mayo co-founded the cartel in the 1980s along side Joaquín "El Chapo" Guzmán. Since El Chapo's incarceration in the United States in 2019, El Mayo has been sole head of the Sinaloa Cartel. Authorities also arrested El Chapo's son, Joaquin Guzman Lopez. The Sinaloa Cartel has been a major player in the cross border drug trade, and has often used extreme violence to further their aims.

[its-vishnu-stuff]

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[ms-demeanor]

So I've been seeing some discourse around the No Fly List leak that looks a bit like "hey everybody, we can't make jokes about this, the list is racist and there are children on the list" or "if you're talking about identity categories instead of the list you're missing the point" and I think that we CAN make jokes about a trans bi lesbian catgirl owning the US government while also appreciating the gravity of the No Fly List but what I think is troubling to me is the way that these discourse posts are treating the blatant racism and inherently fascist nature of the No Fly List as news.

It is news that Maia Arson Crimew was able to download a copy of the No Fly List from an unsecured public server.

It is not news that there are 1.5 million people on that list, many of whom do not belong on it for any number of reasons, and it is not news that there are children on that list, and it is not news that the list is a tool used to deprive people of their civil liberties. That's why the list exists.

I'm aware that I'm getting older. I'm aware that there are entire adults of legal drinking age who were born after 9/11. I'm aware that it's not super common to follow up on foreign policy or national security debacles from when you were in kindergarten, but there are people who have been mad about this shit for twenty years and if you're just now hearing about how bad the list is for the first time, hell, maybe that's on us and we haven't been yelling enough (though when I'm yelling about how the TSA is security theater meant to make us accept encroachments on our rights, this is at least a part of what I'm yelling about).

The No Fly List is a list of individuals maintained by the TSA who are deemed a threat to security for some reason or another.

The TSA maintains the list, though they are given information for the list from the FBI, Terrorism Screening Center, and other entities. If you'd like to click this document, you can find 250 pages of FOIA'd documents about the No Fly List pre 2006. Much of this document is members of the FBI trying to justify why they need a copy of the list and lamenting that airlines have a copy of the list and they don't. This is very funny.

There have been issues with mis-identifications and false positives for the list for as long as the list has existed. You can click here to read through an infuriating 200 pages about a Pfizer employee who was stopped at least a dozen times at airports and who retained a law firm to hound the TSA/CBP/ICE clusterfuck of interagency buck-passing for nine months to try to get the problem resolved. One of the three documents at this link includes a complaint from the president of the Terrorist Screening Center lamenting the way that the TSA would refer obvious non-matches to be detained, including infants and the elderly.

At this point, the FBI/TSA/TSC/ICE/CBP claimed list was still relatively small, in the low thousands at most.

However a 2009 cost-benefit report by the Defense Technical Information Center found that in 2004-2005 30,000 people contacted the TSA to have their names removed from the list; 30k false positives suggests a list somewhat longer than a thousand names.

As long as the No Fly List has existed, criteria for being placed on the list has been subjective and selectively enforced.

As the Crimew leak shows, there isn't a tremendous amount of biographical data, but there are hundreds of thousands of names and it is enforced at the discretion of the TSA in each individual airport in the US, which is how you end up with duplicates and toddlers and 100-year-old men on what is functionally a filter to keep Muslim people out of the US.

The list has expanded every year that it has existed, and has been defended by republicans and democrats alike since it became one of the tools in our arsenal to fight "the war on terror"

And for just about that long, people have been talking about how it is unconstitutional, denies civil liberties, and also just doesn't really work.

It has never been transparent, it has always been a tool of surveillance, exclusion, and control:

And people have been documenting, protesting, and suing over the islamophobic nature of the list - and the security state's weaponization of the list as a threat - for two decades at this point because in the earliest days of the No Fly List it was OPENLY ACKNOWLEDGED that it was based on racial profiling and people made (shitty, cruel) legal arguments for why it should be:

THIS isn't funny. These are not the things that people are joking about when they choose to stay silly :3 in this conversation.

But these things also aren't news. Nearly everything I screencapped here was listed as a source on Wikipedia, and what wasn't was available as simple searches on Archive.Org or easily looked up on news websites.

All you have to do is just *look* at the sources on Wikipedia to see that people actually have been talking about it for quite a long time, very publicly, and that there has been a lot of public outcry about the list as it balloons and punishes innocent people with false positives:

And when you've been looking at stories like these for twenty fucking years it feels wonderful to say "holy fucking bingle" and celebrate that for once someone did something VERY COOL in order to shine a light on this massive (and apparently underappreciated problem).