#Chikungunya

[bpod-bpod]

Virus Hideout

The mosquito-borne virus chikungunya, affecting about 3 million a year globally, can cause long term arthritis, among other complications. On infection, macrophages – large cells of the immune system – are chikungunya reservoirs which can be reactivated. This study reveals the molecular mechanisms of entry, production and spread of the virus in and from macrophages

Read the published research article here

Image from work by Zhenlan Yao and colleagues

Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in The EMBO Journal, September 2024

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[allthebrazilianpolitics]

Brazil records 254,000 chikungunya cases and 161 deaths in 2024

With 254,095 probable cases in Brazil in 2024, along with 161 confirmed deaths and 155 still under investigation, chikungunya is increasingly gaining national significance. This assessment was provided by Rivaldo Venâncio, the Assistant Secretary for Health Surveillance at the Ministry of Health, in his comments on the current state of arboviruses in the country.

"Fortunately, we've observed a decline in the number of cases for nearly ten consecutive weeks, similar to what we've seen with dengue," he stated during a meeting in Brasília. The current chikungunya incidence rate in Brazil stands at 125.1 cases per 100,000 inhabitants.

Most infections occurred among women, who made up 60 percent of the cases. In terms of race, 66.7 percent of cases were among brown people, followed by whites at 24.4 percent, blacks at 7 percent, Asians at 1.5 percent, and indigenous people at 0.2 percent. The age groups most affected by the disease were those aged 20 to 29, followed by 40 to 49, 30 to 39, and 50 to 59, respectively.

Continue reading.

[todaynewspakistan0]

🌟 Chikungunya: What You Need to Know! 🦟

The NIH has issued an important advisory about Chikungunya, a viral infection spread by Aedes mosquitoes. Recent outbreaks remind us of the importance of prevention.

💡 Key Facts:

Symptoms: fever, joint pain, and rash

Transmission: Aedes mosquitoes, mainly during the day

Prevention: Eliminate breeding sites and use repellent

Stay informed and protect yourself and your community! For more details, visit [https://todaynewspakistan.com/nih-issues-advisory-on-chikungunya-infection/].

[cientirinhas]

[biotichealthcare]

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[athenese-dx]

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[cubojorbr]

Extrato de própolis mostra ação antiviral contra zika, chikungunya e mayaro

Pesquisa conduzida no Instituto Butantan busca identificar um composto que possa ser usado tanto na prevenção quanto no tratamento de arboviroses

Fernanda Bassette |Agência FAPESP – Pesquisa realizada por cientistas do Instituto Butantan, em São Paulo, constatou que o extrato aquoso de própolis é capaz de combater a replicação dos vírus zika, chikungunya e mayaro. Os três patógenos são transmitidos pela picada de mosquitos que circulam no Brasil e causam doenças infecciosas (arboviroses) para as quais ainda não existem vacina nem…

[revista-amazonia]

Novas estratégias de controle da dengue e Aedes Aegypti excluem o fumacê

  Em um país polarizado, há uma unanimidade entre os brasileiros: o mosquito Aedes aegypti, transmissor de doenças como Dengue, Zika, febre amarela e Chikungunya, deve ser combatido. Este pequeno inseto pode depositar até 450 ovos durante sua vida de 30 dias, e seus ovos podem sobreviver por um ano sem água, aguardando uma fonte para se desenvolverem em apenas 30 minutos. Originário da África, o…

[pathologylab]

Detect #Chikungunya with #G2M's Chikungunya-Q #RTPCR Kit, offers a quick and reliable way to identify the Chikungunya virus qualitatively in clinical samples. This kit helps #healthcare providers confirm #diagnoses, monitor the spread of the #virus, and take prompt action to prevent further transmission.

Contact us at social@genes2me.com or +91-8800821778 if you need any further assistance! Visit our website for more information: https://www.genes2me.com/ivd-real-time-pcr-test-kits/vector-borne-transmission-detection-kit/chikungunya-testing-pcr-kit

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[bpod-bpod]

Change the Channel

Blocking the budding of viruses – when they wrap themselves in the host cell membrane and move off to spread the infection – could be a good strategy to stop them in their tracks. Researchers interested in alphaviruses – a type that includes chikungunya and Sindbis viruses – examined the role of a protein called 6K in virus assembly and spreading. They found that it functions as a channel to let molecules pass through membranes, like has been seen in proteins of HIV and influenza. This ion channel activity was needed for the formation of vacuoles in the cell, which promote the transport of proteins to the cell lining where they are incorporated into new virus particles (these proteins in red spread throughout the membrane, left, compared to clumping in the absence of 6K, right). Interfering with 6K action could be a new way to treat infection, and nip budding in the bud.

Written by Anthony Lewis

Image from work by Zeinab Elmasri and colleagues

Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, USA

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in PLOS Pathogens, October 2022

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[allthebrazilianpolitics]

Retrospective epidemiologic and genomic surveillance of arboviruses in 2023 in Brazil reveals high co-circulation of chikungunya and dengue viruses

Background

The rapid spread and increase of chikungunya (CHIKV) and dengue (DENV) cases in Brazilian regions in 2023 has raised concerns about the impact of arboviruses on public health. Epidemiological and genomic surveillance was performed to estimate the introduction and spread of CHIKV and DENV in Brazil.

Methods

This study obtained results from the Hermes Pardini (HP), a private medical laboratory, and the Health Department of Minas Gerais state (SES-MG). We investigated the positivity rates of CHIKV and DENV by analyzing the results of 139,457 samples tested for CHIKV (44,029 in 2022 and 95,428 in 2023) and 491,528 samples tested for DENV (163,674 in 2022 and 327,854 in 2023) across the five representative geographical regions of Brazil. Genome sequencing was performed on 80 CHIKV and 153 DENV samples that had been positive for RT-PCR tests.

Results

In our sampling, the data from CHIKV tests indicated that the Northeast region had the highest regional positivity rate in 2022 (58.1%). However, in 2023, the Southeast region recorded the highest positivity rate (40.5%). With regard to DENV, the South region exhibited the highest regional positivity rate in both 2022 (40.8%) and 2023 (22.7%), followed by the Southeast region in both years (34.8% in 2022; 21.4% in 2023). During the first 30 epidemiological weeks of 2023 in the state of Minas Gerais (MG), there was a 5.8-fold increase in CHIKV cases and a 3.5-fold increase in DENV compared to the same period in 2022. Analysis of 151 new DENV-1 and 80 CHIKV genomes revealed the presence of three main clusters of CHIKV and circulation of several DENV lineages in MG. All CHIKV clades are closely related to genomes from previous Brazilian outbreaks in the Northeast, suggesting importation events from this region to MG. We detected the RNA of both viruses in approximately 12.75% of the confirmed positive cases, suggesting an increase of co-infection with DENV and CHIKV during the period of analysis.

Conclusions

These high rates of re-emergence and co-infection with both arboviruses provide useful data for implementing control measures of Aedes vectors and the urgent implementation of public health politics to reduce the numbers of CHIKV and DENV cases in the country.

Read the paper.

[addonhealthcare]

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[cientirinhas]

[biotichealthcare]

Unfortunately, India has reached in the season where dengue and chikungunya are now circulating, and recently there’s been a various national media clauses about ‘Dengue & Chikungunya’ cases in India. With memories of 2006 prevalent still in mind, perhaps hearing about dengue is not surprising, but the reality is that today, ‘Dengue’ is considered as a regular and seasonal malady strains.