#Anti-Ageing

[inventforgood]

My idea is that cDNA libraries of the mRNA from humans of different ages, eg 1 year, 5 years, 10 years, 15 years, 22 years, 30 years, 40 years, 55 years, 70 years and 85 years (but practically it would be necessary to just take the samples that became available!) could be constructed or acquired. They could also be acquired from specific “aging critical” tissues/organs eg endothelium, cardiac, pulmonary, kidney, brain etc. The cDNA libraries could be compared by constructing microarrays (that is my dated knowledge but today it could probably be done computationally).

What would that give us? By the differences in the transcriptome between the different age cohorts it would show the difference between aged tissues and young tissues.

Of course, how these differences arose is AS a result of the epigenetic processes, but the differences themselves ARE the results of the epigenetic processes and (in some way which I am not able to imagine right now) may lead to approaches to discover more about the epigenetic processes themselves, which is your interest. Please forgive me if I am telling you things that are already second nature to you, but there is more to my proposal which is in fact quite simple really although very broad in scope and ambitious in outcome.

The differences mentioned above would be either the absence of specific mRNA in older tissues that is present in younger tissues, or vice versa, or quantitative differences in levels of mRNA.

That then gives a series of mRNA targets to investigate, both upstream, in terms of regulation of transcription such as transcription factors and silencing, and downstream in terms of identifying and characterising the protein product of the mRNA, its structure, binding sites, effects etc. That as you said before is quite a considerable body of work and would require many teams of researchers.

As far as intervention to promote health is concerned, discovering the epigenetic processes which cause the changes would be one pathway to treatments; other pathways could be pharmaceutical, perhaps based on transcription factors, and gene-therapy based approaches.

I think that the approach I have outlined is slightly different to that of the Yamanaka factors, which reset some cells to pluripotent stem cells, as my approach is intended to make differentiated cells youthful but still basically differentiated, as in the functioning young

adult.

I have heard of a researcher called Jaoa de Magalhaes who was said to be doing something like what I suggest (and he has now moved to Birmingham University in Britain) but I do not see mention of it on his website, he talks about long lived species, another interesting approach. An academic in Cambridge told me that she had heard of something like this that I propose being done in Singapore, but did not know the name of the researcher. So, although this approach is not truly novel, I believe it is still new ground.

[mediocre-megs]

honestly more media should portray the anti aging industry as horrific and decidedly unhuman. it IS body horror it IS grotesque it DOES go against nature. it WILL kill you. yes.

[art-of-vedas]

[justnadiene]

BeautyPRO LED Wand: Redefining Skincare with Cutting-Edge Technology

Introducing the BeautyPRO LED Wand, a cutting-edge skincare device that harnesses the power of Red and Blue Light technology, EMS Microcurrent, Thermotherapy, and High-Frequency Sonic Vibration to elevate your skincare routine. This rechargeable skin device offers a comprehensive solution to address various skin concerns and help you achieve your skincare goals. The BeautyPRO LED Wand is…

[techdriveplay]

How to Take Care of Your Face and Beard: Insights on Men's Skincare from Manuel Naci

Today, we share insights from Manuel Naci, a renowned expert in men’s skincare and grooming, on the best practices for taking care of your face and beard. Manuel explains why maintaining good skin and beard health is essential for men, offering practical advice on routines, products, and the unique needs of male skin. Discover the secrets to achieving a healthier, more confident appearance, and…

[thebingomaster]

Where to buy DHEA in the UK?

DHEA can be purchased from here or click on the links below for specific dosages

Life Extension DHEA 15mg x 100 Capsules

Life Extension DHEA 25mg x 100 Capsules

Life Extension DHEA 25mg x Vegetarian dissolve in the mouth tablets

Life Extension DHEA 50mg x 60 Capsules

[scienceofbeauty]

Why Teoxane Is The Best Choice For Anti-Aging Skincare

As we age, our skin undergoes several changes that lead to wrinkles, fine lines, dryness, and numerous other signs of ageing. While ageing is inevitable, you can slow it down and reduce its signs by using anti-ageing skincare products.

To Read More: Why Teoxane Is The Best Choice For Anti-Aging Skincare

The Science of Beauty

[catforsley]

Lise Watier - Skincare Review

Happy April! About a month ago – Lise Watier pr sent me some beautiful skincare for editorial purposes.- Here I am Now with my thoughts on these 5 gorgeous products.       Let’s dive right in . Age Control Supreme Sublime Advanced Day Cream Global anti-aging skincare for all skin types $120.00 CAD Enriched with a powerful shield of Canadian antioxidants, this deeply replenishing, age-defying…

[valenschirico]

dear, Klairs Freshly Juiced Vitamin E Mask – review and b&a

A pudding before going to bed? Bad idea unless it's for your #skin. Read more about dear, Klairs Vitamin E Mask. #Koreanskincare

  Find the best partner for your dear, Klairs Freshly Juiced Vitamin Charging Serum in dear, Klairs Freshly Juiced Vitamin E Mask, like jelly for your skin.   Should you have a dessert before going to sleep? No, but your skin might have a spoon of dear, Klairs Freshly Juiced Vitamin E Mask to wake up suppler. dear, Klairs Freshly Juiced Vitamin E Mask: product & packaging Freshly Juiced…

[xhosabits]

Introducing L'Oréal Men Expert Power Age: The Ultimate Hydrating and Anti-Ageing Skincare Range for Men

Introducing L'Oréal Men Expert Power Age: The Ultimate Hydrating and Anti-Ageing Skincare Range for Men

[urloveangel]

my favourite anti-aging methods are inner peace, forgiveness and minding my business

[blackandredblog]

Tim Gurner: Workers Have it Too Easy

Tim Gurner, an Australian billionaire real estate developer, snake oil salesman, and grifter, has been in the spotlight for his commentary about the need to control the lower classes through unemployment and financial hardship. What did Tim Gurner Say? “I think the problem that we’ve had is that people decided they didn’t really wanna work so much any more and that has a massive issue on…

[alivewellnessclinics]

While often associated with wrinkles and lines, the essence of anti-aging is far more profound. At Alive Wellness Clinics, we approach this journey holistically, recognizing that true radiance emerges from skin health nurtured within.

[thebingomaster]

Optimising Health with DHEA: Immune Support and Metabolic Benefits

Dehydroepiandrosterone, commonly known as DHEA, is a hormone produced by your adrenal glands. It serves as a precursor to male and female sex hormones, including testosterone and estrogen. As we age, the natural production of DHEA declines, often leading to various health issues. Supplementing with DHEA can offer a range of benefits, promoting overall well-being and addressing age-related concerns.

Hormone Balance and Mood Enhancement

One of the primary benefits of DHEA supplementation is its ability to help balance hormones. DHEA serves as a building block for sex hormones, and maintaining adequate levels can help regulate these essential hormones. Balanced hormones are crucial for mood stability, energy levels, and overall mental health. Studies have shown that DHEA supplementation can improve mood and reduce symptoms of depression, particularly in individuals with low DHEA levels (Wolkowitz et al., 1999).v

Bone Health and Muscle Strength

DHEA plays a vital role in maintaining bone density. As we age, the risk of osteoporosis and fractures increases, especially in postmenopausal women. Research indicates that DHEA supplementation can help improve bone mineral density, thereby reducing the risk of osteoporosis (Baulieu et al., 2000). Additionally, DHEA has been linked to increased muscle mass and strength, making it a popular supplement among older adults and athletes looking to preserve muscle integrity and enhance physical performance (Villareal et al., 2004).

Cognitive Function and Anti-Aging Properties

Cognitive decline is a common concern as we age. DHEA has been associated with improved cognitive function and memory. Supplementing with DHEA can help protect against age-related cognitive decline, promoting mental clarity and sharpness (Wolkowitz et al., 2002). Furthermore, DHEA possesses anti-aging properties, contributing to youthful skin and reduced wrinkles by promoting collagen production. This makes DHEA a valuable addition to any anti-aging regimen.

Immune System Support

A robust immune system is essential for defending against illnesses and infections. DHEA has been found to enhance immune function, providing an added layer of protection against pathogens. This immune-boosting property is particularly beneficial for older adults, whose immune systems tend to weaken with age (Khorram et al., 1997).

Weight Management and Metabolic Health

DHEA supplementation can also aid in weight management and metabolic health. It helps regulate fat metabolism, which can assist in reducing abdominal fat and improving body composition. Additionally, DHEA has been shown to enhance insulin sensitivity, which is crucial for preventing and managing conditions like type 2 diabetes (Villareal et al., 2004).