#💊kill

[joejoeba]

[illsadboy]

Mi vorrebbero trascinare in clinica per farmi curare ma non esiste medicinale se nel bene vedo sempre il male.

[anchor-dreamss]

miss you everyday little brother, Jeff Hedger 🩷

[0the-anomaly-system0]

jericho? more like chairicho.

[godblooded]

if i leave with gloria in my pocket tomorrow well i won’t be surprised.

[dingdongdoodilydoodilydoo]

Mommy and the middle child having something special? Unexpected-

...shut up all we do is eat food and vent

[remedicine]

crying and sobbing and choking on my own tears rn

[xtruss]

HIV Cure Nearer With Way To 'Shock And Kill' Latent Virus

— Published March 27, 2024 | Newsweek

A Stock iIlustration Shows the Human Immunodeficiency Virus. Researchers May Have Found a Way to Remove Latent HIV From Cells, According to a New Study. IStock/Getty Images Plus

We might be a step closer to curing HIV, as researchers have developed a way to knock out a version of the virus lurking in the body.

Using something called an HIV-like particle (HLP)—which are dead HIV particles containing HIV proteins that trigger an immune response in a patient—may help treat the disease, scientists from the University of Western Ontario's Schulich School of Medicine and Dentistry and the U.K.'s University of Bristol reveal in a paper in the journal Emerging Microbes & Infections.

HLP was found to be 100 times more effective at treating the virus in people living with chronic HIV while on combined antiretroviral therapy (cART) than other candidate HIV cure therapeutics.

HIV, or human immunodeficiency virus, attacks the immune system, specifically targeting CD4 cells, which are crucial for helping the body fight infections and diseases. Without treatment, HIV can progress to the more advanced stage called AIDS, which can lead to death in only a few years.

More than 1.2 million people across the U.S. have HIV, with over 30,000 new cases diagnosed every year. There is no cure for HIV, but several treatments are available that can allow patients to live a long life.

HIV is treated primarily with cART, which is a combination of medications designed to suppress the replication of HIV in the body. This therapy works by targeting different stages of the HIV life cycle, preventing the virus from multiplying and reducing its levels in the bloodstream.

The goal of cART is to reduce the viral load (the amount of HIV in the blood) to undetectable levels, allowing the immune system to recover and preventing the progression of HIV to AIDS. However, cART doesn't completely eliminate the virus from the body, and the virus creates a "latent reservoir" where it hides within the cells of the body, lying dormant.

According to the new paper, HLP can help to purge cells of this latent HIV, making it a major step forward in treating and curing the infection.

"The development of this HIV cure was ten years in the making but with strong support from our collaborators in the US, Canada and Uganda, we have observed a striking ability of HLP to drive out the last remnants of HIV-1, which we hope will provide an affordable cure for all," said Eric Arts, the Canada research chair in HIV pathogenesis and viral control at the Schulich school, in a statement.

"To live HIV-free is a goal for the 39 million infected. It is also the priority of the UN and WHO to end the HIV pandemic by 2030," he added.

HLP, a deactivated version of HIV, contains various proteins that make it recognizable to the body as the virus, triggering an immune response. But it doesn't contain any of the structures that make the virus harmful and immunocompromising. HLP can therefore trigger the immune system to go hunting after HIV viruses remaining in the body, including the latent viruses hidden inside the immune cells. This allows the body to "shock and kill" the hidden viruses, the researchers said in the paper.

The researchers used blood samples from 32 patients with chronic HIV from the U.S., Uganda and Canada who had been on stable cART for a median of approximately 13 years. They found that HLP was able to specifically target just the immune cells containing a latent HIV reservoir, removing the virus from the cells.

"Over time, the virus grows more diverse within a single individual that is not on treatment which makes it more difficult to target," co-author Ryan Ho, a master's student at the Schulich school, said in the statement. "This formulation we've crafted covers the theoretical diversity so it can reach the HIV-1 in all those people living with HIV."

This is an extremely exciting discovery for HIV researchers, as it could be combined with cART and one day lead to the total elimination of HIV from the bodies of patients.

Minh Ha Ngo, the paper's lead author and a postdoctoral scholar at the Schulich school, said in the statement: "One concern expressed among people living with HIV for years is that continued use of cART could lead to the virus becoming unreachable and unable to be eliminated.

"The results of this study, by contrast, demonstrate that combining HLP with cART is still able to trigger the latent reservoir, even in chronic cases. If these dormant latent reservoirs can be awakened, then they can be eliminated from the body," Ngo said.

Additionally, HLP appeared to work on all variants of HIV from around the planet, indicating that it could be successful at treating even mutated versions of the virus.

"Owing to its high mutation rate, HIV exhibits remarkable genetic diversity, resulting in different viral subtypes, some of which predominate in particular regions of the globe," said Jamie Mann, a senior lecturer in vaccinology and immunotherapy at the University of Bristol's Veterinary School, in the statement.

"We were excited to see preliminary evidence that our HLP cure therapy reverses latency irrespective of the subtype of the individual's infection. Whilst this needs to be explored further, it hints at the global applicability of our approach," Mann said.

The researchers hope to test this HLP treatment across a larger cohort of people around the world to determine if it is an effective treatment strategy for those with both chronic and acute HIV.

— Jess Thomson is a Newsweek Science Reporter based in London UK 🇬🇧

[evilscientist3]

[🔬 Microscope equipped.]

🧫 e-colin Follow Another day, another dollar trying to infect this host! Rise and grind pathogens 💸

4 μnotes

🦠 cell287776540923 Follow might fuck around and reactivate my oncogenes later

💊 mr-t-cell1989 grins at you violently

2,334 μnotes

🦠 natkiller28937 Follow Who up patrolling the body for cells without MHC Class I molecules 😎😎

🧬 nora-virus Follow You know what? This isn't okay. Pathogens work hard to infect host cells and reproduce. It's the only way for them to perpetuate their own existence. Letting pathogens infect host cells is absolutely necessary to prevent their total extermination. Killing is wrong! Immune cells need to learn to be tolerant of other microbes instead of destroying us just because we want to seize and consume this body's resources.

💊 mr-t-cell1989

KUNG

🦠 natkiller71642 Follow

POW

🩸 neutro-phil2

PENIS

30 trillion μnotes

[wormonastringtheory]

"kill em with kindness" wrong potion of transexuality

🏳️‍🌈💥💫🧑‍🔬🎊🎉🪄🧪⚗️💊⚧️♀️♂️❓✔️🏳️‍⚧️

[blanksoullesseyes]

[fuckmarrypoll]

[k1tkatzzz]

“kill em with kindness” wrong!! get squipped 💊💊💊💊💊💊💊💊💊💊💊💊💊💊💊 💊💊💊💊💊💊💊💊💊💊💊💊💊💊💊 💊💊💊💊💊💊💊💊💊💊💊💊💊💊💊 💊 💊💊💊💊💊💊💊💊💊💊💊💊💊💊💊 💊💊💊💊💊💊💊💊💊💊💊💊💊💊 💊💊💊💊💊💊💊💊💊💊💊💊💊💊💊 💊💊💊💊💊💊💊💊💊💊💊💊💊💊💊 💊💊💊💊💊💊💊💊💊💊💊💊💊💊💊 💊💊💊💊💊💊💊💊💊💊💊💊💊💊💊 💊💊💊💊💊💊💊💊💊💊💊💊💊💊💊

[cupidsworstcrime]

Greg House Headcanons - 💊

---

sfw

He's not big on PDA, but once when you were going to have lunch with him, he was so exhausted that he actually kissed your forehead in the middle of the hall.

He doesn't believe in pet names, he (affectionately) calls you dumbass

You're the one that asked him out, he stood you up. Twice. You gave up, but then he asked you out, you were tempted to stand him up, but Wilson convinced you that he was actually going to show up

You've offered to have an open relationship, cause him and Wilson seem too close for their own good, he turned it down. But considering Wilson is his 'soulmate' you don't consider it cheating. It's just you, your boyfriend, and your boyfriend's husband.

Surprisingly, he "doesn't" pick favorites at work, he has yelled at you more times than you care to remember. He's just a good doctor, it has nothing to do with your relationship. (He definitely has favorites.)

nsfw

A surprising amount of stamina, annoyingly so. You LOVE that he lasts longer than a minute, but after 3 hours when your cunt is sore, you're drooling into a pillow and he still has more to give, you genuinely think about killing him.

He once called you Wilson during sex, sparking that 'open relationship' conversation again.

He once called you Cuddy once during sex. Which you did not understand as much as the Wilson thing (He made it up to you after you refused to cuddle him)

You're like 87% sure he's into cucking but he denies it.

He's not super kinky, he likes breeding, tying your wrists sometimes, but he's not one to be rough.

[kisses4reid]

masterlist 💋

❣️- fluff

🥀- angst

💊- comfort

spencer reid

❣️convenient (2 3 4 5) - studying while working at a convenience store is helpful when a regular happens to be a genius

❣️big change - you cut spencer’s hair, the close proximity makes you nervous, and his new haircut makes him confident

❣️🥀 missed it - every forgets your birthday except spencer

❣️ missed it part 2 - garcia remembers and scolds the team for forgetting

❣️🥀 criminally hot - reader gets falsely accused and spencer has to expose your relationship to clear you

❣️🥀 untitled - rejecting spencer’s confession because of insecurity, and spencer convincing you his love is real

❣️ protect - reader’s pregnant, and a trip to the hospital ruins the surprise

❣️🥀 understand? - reader is a translator, spencer is fascinated with her intelligence (part two here)

🥀 untitled - killing your kidnappers and spencer finding you

❣️untitled - ballerina!r x downbad!spencer

❣️sleep talking - reader sleep talks, spencer keeps you close

❣️cuddles - reader’s and spencer’s daughter has a nightmare

aaron hotchner

💊🥀 untitled - stressed with red hands under an all too bright bathroom, your panic attack is avoided with the help of your boss (WARNING: mentions of blood)

💊❣️red tissues - you get nose bleeds regularly, aaron learns when you’re about to have one, comfort ensues (WARNING: lots of blood and mentions of severe sickness)

❣️ruined surprises - you find a small velvet box in one of aaron’s drawers

❣️date night - you come home drenched to a forgotten date with aaron, but he doesn’t mind

[dingdongdoodilydoodilydoo]

What do you think of Ghost (the band)?

ohhh you meaj the 8 fucking oerson band run by a swedish man who hires and replaced people constantly?

a bunch of oussies in masks, the only song i like js Jigolo Har Megiddo