#💊kill

[joejoeba]

[illsadboy]

Mi vorrebbero trascinare in clinica per farmi curare ma non esiste medicinale se nel bene vedo sempre il male.

[anchor-dreamss]

miss you everyday little brother, Jeff Hedger 🩷

[0the-anomaly-system0]

jericho? more like chairicho.

[godblooded]

if i leave with gloria in my pocket tomorrow well i won’t be surprised.

[dingdongdoodilydoodilydoo]

Mommy and the middle child having something special? Unexpected-

...shut up all we do is eat food and vent

[npd-writtenby-odetari]

Everyone here is pissing me off. You can be patient. Shut the fuck up and let me do our job.

[darthteeth]

URGENT!!!Help Abdul Salam Al-Anqar and his family get through this war in Gaza!!!

(URGENT) THEY ARE AT €3,445 OUT OF €50,000 GOAL

I was asked by @nader5555 to make this, if u cannot donate please please share this post. Copy pasted from a message i was sent:

"Only a Few Hours Left Before We Enter Our First Year of War, Genocide, Starvation, and Displacement A Final Plea from the Heart of Hell: Save Us Before Hope Dies 💔🔥 I am Abdel Salam, and I have nothing left but words written by a trembling hand ✍️. The war has not only destroyed our lives; it has taken everything from us. Our home, which was once our refuge, is now a pile of rubble 🏚️.

My car, my only source of livelihood, was destroyed in a sudden strike 🚗, and the work that sustained us is now a distant memory 💼. Today, I live in an endless nightmare. Under a sun that burns everything in its path 🌞🔥, my family and I sit in a worn-out tent, a tent that shields us neither from the summer heat nor the winter cold ❄️. Insects 🦟 invade the place, diseases consume our bodies 🩺, and my younger siblings cry from hunger and thirst 🍞💧. We have no clean water or a crumb of bread to ease our hunger. Each passing day deepens the weight of this hell we live in.

My Daughter Eman is Dying from Malnutrition 😨 My daughter Eman suffers from malnutrition; I have nothing to feed or treat her with. The deterioration of her health is killing me slowly. Every glance in her eyes, every pain she endures, crushes my heart 💔. How can I explain to her that what was once our hope has now turned into nothing but a mirage? The Night Only Adds to Our Pain 🌙 The night does not bring us rest; it only adds to our pain. We sleep on hard ground, feeling the cold in every bone of our bodies 🥶, with nothing but pieces of cardboard 📦 to cover us. My wife Aya cries in silence 🥺 as she watches our daughter’s future fade before her eyes. My mother Eman suffers from illness and needs urgent medical care 🩺💊.

My Father Ahmed is Sick with Cancer and Needs Emergency Treatment My father Ahmed, who is sick with cancer, needs emergency treatment outside Gaza, and the cost of his treatment is at least $10,000, not including accommodation. As he suffers from severe pain, I cannot provide the treatment he needs due to our dire situation.

My Siblings Are in Constant Suffering ⚰️ My brother Omar was unable to continue his studies due to the situation. My brother Nader could not take his high school exams, and my younger brother Mohammad suffers from brittle bones and needs treatment we cannot afford. Every day we live brings us one step closer to the end. Death surrounds us from every side: if not from hunger 🍽️, then from illness 🦠. And if not from illness, then from the despair that devours our souls. Where is Humanity? Where is the World? 🌍💔 We want to leave the devastated Gaza Strip to escape the machinery of destruction and killing and the severity of hunger and poverty. The cost of travel for each person is $5,000, and we are a family of seven members, bringing the total cost to $35,000.

Where are the compassionate hearts? Are you waiting for us to disappear into the depths of this suffering? Are you waiting until death takes us before you act? We are drowning, and we don’t have enough strength to scream for help 🆘. Will you let this cry go unanswered? 😭 Your donation today is our last thread of hope. With the little support I received, I was able to buy a simple phone 📱 to reach out to you. But the bitter truth is that what I and my family need is much greater. We are not asking for much; just enough to save our lives from this hell 🔥. Every donation, no matter how small, could be the difference between life and death for us 👐. Don’t Let Us Disappear in the Darkness of Suffering 🌑 Don’t let our story end here. Be the light that guides us to salvation 🕯️✨.

With every tear, with every pain, I write this final plea to you, Abdel Salam."

taglist

@butchniqabi @xinakwans

@batekush

@appsa

@nerdyqueerr

@butchsunsetshimmer

@biconicfinn @stopmotionguy

@t4tvampireisms

@strangeauthor

@bryoria @shesnake

@legallybrunettedotcom

@lautakwah @sovietunion

@neechees @evillesbianvillain @antibioware

@akajustmerry @dizzymoods

@ree-duh @neptunerings

@explosionshark

@heritageposts

@ibtisams

@schoolteacher

[xtruss]

HIV Cure Nearer With Way To 'Shock And Kill' Latent Virus

— Published March 27, 2024 | Newsweek

A Stock iIlustration Shows the Human Immunodeficiency Virus. Researchers May Have Found a Way to Remove Latent HIV From Cells, According to a New Study. IStock/Getty Images Plus

We might be a step closer to curing HIV, as researchers have developed a way to knock out a version of the virus lurking in the body.

Using something called an HIV-like particle (HLP)—which are dead HIV particles containing HIV proteins that trigger an immune response in a patient—may help treat the disease, scientists from the University of Western Ontario's Schulich School of Medicine and Dentistry and the U.K.'s University of Bristol reveal in a paper in the journal Emerging Microbes & Infections.

HLP was found to be 100 times more effective at treating the virus in people living with chronic HIV while on combined antiretroviral therapy (cART) than other candidate HIV cure therapeutics.

HIV, or human immunodeficiency virus, attacks the immune system, specifically targeting CD4 cells, which are crucial for helping the body fight infections and diseases. Without treatment, HIV can progress to the more advanced stage called AIDS, which can lead to death in only a few years.

More than 1.2 million people across the U.S. have HIV, with over 30,000 new cases diagnosed every year. There is no cure for HIV, but several treatments are available that can allow patients to live a long life.

HIV is treated primarily with cART, which is a combination of medications designed to suppress the replication of HIV in the body. This therapy works by targeting different stages of the HIV life cycle, preventing the virus from multiplying and reducing its levels in the bloodstream.

The goal of cART is to reduce the viral load (the amount of HIV in the blood) to undetectable levels, allowing the immune system to recover and preventing the progression of HIV to AIDS. However, cART doesn't completely eliminate the virus from the body, and the virus creates a "latent reservoir" where it hides within the cells of the body, lying dormant.

According to the new paper, HLP can help to purge cells of this latent HIV, making it a major step forward in treating and curing the infection.

"The development of this HIV cure was ten years in the making but with strong support from our collaborators in the US, Canada and Uganda, we have observed a striking ability of HLP to drive out the last remnants of HIV-1, which we hope will provide an affordable cure for all," said Eric Arts, the Canada research chair in HIV pathogenesis and viral control at the Schulich school, in a statement.

"To live HIV-free is a goal for the 39 million infected. It is also the priority of the UN and WHO to end the HIV pandemic by 2030," he added.

HLP, a deactivated version of HIV, contains various proteins that make it recognizable to the body as the virus, triggering an immune response. But it doesn't contain any of the structures that make the virus harmful and immunocompromising. HLP can therefore trigger the immune system to go hunting after HIV viruses remaining in the body, including the latent viruses hidden inside the immune cells. This allows the body to "shock and kill" the hidden viruses, the researchers said in the paper.

The researchers used blood samples from 32 patients with chronic HIV from the U.S., Uganda and Canada who had been on stable cART for a median of approximately 13 years. They found that HLP was able to specifically target just the immune cells containing a latent HIV reservoir, removing the virus from the cells.

"Over time, the virus grows more diverse within a single individual that is not on treatment which makes it more difficult to target," co-author Ryan Ho, a master's student at the Schulich school, said in the statement. "This formulation we've crafted covers the theoretical diversity so it can reach the HIV-1 in all those people living with HIV."

This is an extremely exciting discovery for HIV researchers, as it could be combined with cART and one day lead to the total elimination of HIV from the bodies of patients.

Minh Ha Ngo, the paper's lead author and a postdoctoral scholar at the Schulich school, said in the statement: "One concern expressed among people living with HIV for years is that continued use of cART could lead to the virus becoming unreachable and unable to be eliminated.

"The results of this study, by contrast, demonstrate that combining HLP with cART is still able to trigger the latent reservoir, even in chronic cases. If these dormant latent reservoirs can be awakened, then they can be eliminated from the body," Ngo said.

Additionally, HLP appeared to work on all variants of HIV from around the planet, indicating that it could be successful at treating even mutated versions of the virus.

"Owing to its high mutation rate, HIV exhibits remarkable genetic diversity, resulting in different viral subtypes, some of which predominate in particular regions of the globe," said Jamie Mann, a senior lecturer in vaccinology and immunotherapy at the University of Bristol's Veterinary School, in the statement.

"We were excited to see preliminary evidence that our HLP cure therapy reverses latency irrespective of the subtype of the individual's infection. Whilst this needs to be explored further, it hints at the global applicability of our approach," Mann said.

The researchers hope to test this HLP treatment across a larger cohort of people around the world to determine if it is an effective treatment strategy for those with both chronic and acute HIV.

— Jess Thomson is a Newsweek Science Reporter based in London UK 🇬🇧

[evilscientist3]

[🔬 Microscope equipped.]

🧫 e-colin Follow Another day, another dollar trying to infect this host! Rise and grind pathogens 💸

4 μnotes

🦠 cell287776540923 Follow might fuck around and reactivate my oncogenes later

💊 mr-t-cell1989 grins at you violently

2,334 μnotes

🦠 natkiller28937 Follow Who up patrolling the body for cells without MHC Class I molecules 😎😎

🧬 nora-virus Follow You know what? This isn't okay. Pathogens work hard to infect host cells and reproduce. It's the only way for them to perpetuate their own existence. Letting pathogens infect host cells is absolutely necessary to prevent their total extermination. Killing is wrong! Immune cells need to learn to be tolerant of other microbes instead of destroying us just because we want to seize and consume this body's resources.

💊 mr-t-cell1989

KUNG

🦠 natkiller71642 Follow

POW

🩸 neutro-phil2

PENIS

30 trillion μnotes

[destroyingangelneveragod]

"kill em with kindness" wrong potion of transexuality

🏳️‍🌈💥💫🧑‍🔬🎊🎉🪄🧪⚗️💊⚧️♀️♂️❓✔️🏳️‍⚧️

[blanksoullesseyes]

[fuckmarrypoll]

[dakotac0le]

my dealer niklaus: got some straight gas 🔥😛 this strain is called “accent changing weed” 😳💊

me: yeah whatever i dont feel shit

5 min later: top o the mornin to ya. got a cuppa ? 🇬🇧💂‍♂️

my buddy felipe, pacing: ive got to kill gillion

[k1tkatzzz]

“kill em with kindness” wrong!! get squipped 💊💊💊💊💊💊💊💊💊💊💊💊💊💊💊 💊💊💊💊💊💊💊💊💊💊💊💊💊💊💊 💊💊💊💊💊💊💊💊💊💊💊💊💊💊💊 💊 💊💊💊💊💊💊💊💊💊💊💊💊💊💊💊 💊💊💊💊💊💊💊💊💊💊💊💊💊💊 💊💊💊💊💊💊💊💊💊💊💊💊💊💊💊 💊💊💊💊💊💊💊💊💊💊💊💊💊💊💊 💊💊💊💊💊💊💊💊💊💊💊💊💊💊💊 💊💊💊💊💊💊💊💊💊💊💊💊💊💊💊 💊💊💊💊💊💊💊💊💊💊💊💊💊💊💊

[dingdongdoodilydoodilydoo]

What do you think of Ghost (the band)?

ohhh you meaj the 8 fucking oerson band run by a swedish man who hires and replaced people constantly?

a bunch of oussies in masks, the only song i like js Jigolo Har Megiddo