#type 1 diabetes insulin

[reasonsforhope]

"People living with diabetes might have a new hope. Scientists have tested a new drug therapy in diabetic mice, and found that it boosted insulin-producing cells by 700% over three months, effectively reversing their disease.

Beta cells in the pancreas have the important job of producing insulin in response to blood sugar levels, but a hallmark of diabetes is that these cells are either destroyed or can’t produce enough insulin. The most common treatment is regular injections of insulin to manage blood sugar levels.

But a recent avenue of research has involved restoring the function of these beta cells. In some cases that’s started with stem cells being coaxed into new beta cells, which are then transplanted into patients with diabetes. Researchers behind this kind of work have described it as a “functional diabetes cure.”

Now, scientists at Mount Sinai and City of Hope have demonstrated a new breakthrough. Previous studies have mostly involved growing new beta cells in a lab dish, then transplanting them into mice or a small device in humans. But this new study has been able to grow the insulin-producing cells right there in the body, in a matter of months.

The therapy involved a combination of two drugs: one is harmine, a natural molecule found in certain plants, which works to inhibit an enzyme called DYRK1A found in beta cells. The second is a GLP1 receptor agonist. The latter is a class of diabetes drug that includes Ozempic, which is gaining attention lately for its side effect of weight loss.

The researchers tested the therapy in mouse models of type 1 and 2 diabetes. First they implanted a small amount of human beta cells into the mice, then treated them with harmine and GLP1 receptor agonists. Sure enough, the beta cells increased in number by 700% within three months of the treatment. The signs of the disease quickly reversed, and stayed that way even a month after stopping the treatment.

“This is the first time scientists have developed a drug treatment that is proven to increase adult human beta cell numbers in vivo,” said Dr. Adolfo Garcia-Ocaña, corresponding author of the study. “This research brings hope for the use of future regenerative therapies to potentially treat the hundreds of millions of people with diabetes.”

The results are intriguing, but of course being an animal study means there’s still much more work to be done before it could find clinical use. So far, harmine alone has recently undergone a phase 1 clinical trial in humans to test its safety and tolerability, while other DYRK1A inhibitors are planned for trials in humans next year.

Perhaps most importantly, the team will soon experiment with combining beta-cell-regenerating drugs with others that modulate the immune system. Ideally this should help overcome a major hurdle: the immune system will continue attacking new beta cells as they’re produced.

The research was published in the journal Science Translational Medicine."

-via New Atlas, July 14, 2024

[nullroid]

💉💉💉

If you´re a fellow diabetic and you wear your equipment out I love you and it makes my day

Insta | Redbubble

[thatbitchwhohyperfixates]

Hello all diabetics out there I wanted to bring to attention these beautiful websites curated for people with diabetes who are struggling to afford their supplies and or lost insurance recently

This first one is a program dexcom offers to t1d's who need help or can't afford their cgms

https://assistance.dexcom.com/pap_selfservice/

This second one is a $35/m for insulin coupon for people who have no insurance or their insurance is shit

For Lily⏬

Www.insulinaffordability.com

For sanofi⏬

https://www.admelog.com/savings

Please spread this so all diabetics are aware it exists and is available

[allthecanadianpolitics]

Islanders living with Type 1 diabetes are eligible to receive help with the cost of insulin pumps and related supplies beginning Sept. 1. The PEI Insulin Pump Program provides financial assistance to medically eligible residents, according to a news release from the province. The program was previously open to those up to age 25, however the province has now removed that age limit. [...] The province says there are approximately 1,100 people on Prince Edward Island who are living with Type 1 diabetes, which is an autoimmune disease that prevents the pancreas from producing insulin.

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Tagging: @newsfromstolenland

[type1thais]

Introduction:

I'm Thais, 25 yr old type 1 diabetic and LBK amputee because of complications related to diabetes. I workout, eat better and monitor my sugar

[fairydropart]

I’ve finally gotten to try my first insulin pump! So far it’s been really great, although there’s a lot to learn and take into consideration, but I’ve always found it interesting to learn more about my illness and find ways to improve my treatment, so I don’t mind at all. Though I’d share something a little more personal, since it’s something I’ve been looking forward to for over a year now, and, well, I’m pumped to see how this will impact my day to day life! ☺️

[officeobject]

Palestine GoFundMe and a different type of fundraiser!

Answer

ayaaymananqar

8h ago

ayaaymananqar asked:

Hello,

My name is Aya. I am reaching out from Gaza to seek your help in saving my family. I am raising funds to evacuate my family from war-torn Gaza. Every passing minute endangers our lives and increases our suffering, especially with the constant bombing and the lack of food and water supply. 😞😞 Please, extend a hand to save our souls and make the world hear our cry. 💔

✅️Vetted by @gazavetters, my number verified on the list is (#217)✅️

Best regards,

Aya

https://gofund.me/4f615392

(WARNING THAT THE PERSON THERE IS 18+ SO 18+ INTERACTIONS ONLY, BECAUSE NSFW AND STUFF, BUT I'M POSTING THE FUNDRAISER HERE ANYWAY)!

fulldelusioncupcake

1h ago

fulldelusioncupcake asked:

Hi, I hope you are doing well🌹

Can you help by sharing my story, reblog, and donating if you can, to keep hope alive for me, I'm type 1 diabetes. I am calling on your humanity and kindness to help me raise $340.

This amount will enable the approval of an insulin pump that will help me better control my diabetes. Although I am happy that I have been approved the hardest part is the money to pay for the pump and equipment, please your contribution is important. Be blessed ♥️

[arionaleilani]

hello its ur local diabetic trying not to cry in my dr’s office because my a1c has dropped below 9 for the first time since i was probably 19 or 20, being diabetic fucking SUCKS but i’m trying to be better about taking care of myself and taking my health seriously and it’s SHOWING!!! IT’S ACTUALLY SHOWING!! 8.7 MOTHERFUCKERS!!!

[themooncreature]

I swear guys all I did was eat a normal amount of animal crackers and be stressed out. This shit is ridiculous.

[thedeafprophet]

Sometimes I'm just hit with how much stuff we have support for medically these days would be a death sentence in the past

[jamieroyjamieroy]

Damn straight I’m going to use my type 1 diabetes when I don’t want to do something. There are no other perks with this stupid lifelong condition!

[satellites-halo]

Type 1 diabetes blinkies!

I couldn't rlly find any old-web styled chronic illness blinkies, even for diabetes, and I've been feeling weird abt being diabetic recently so... yahoo!

credit me via my neocoties page button maybe? On this page!

[thel1ghtningthief]

hi hi poll for diabetics

no see results option, non insulin pump users please dont vote. if you wanna press a button you can reblog for reach pretty please

[trek-tracks]

Being a Type 1 diabetic Trekkie means that sometimes your two autocorrect suggestions are “insulin” and “I, Sulu”

[chronic-harmonic]

My favorite brand of diabetic tumblr is when someone is posting low blood sugar memes while they’re clearly fighting for their life

[diabeticyborg]

Forgetting to refill your cartridge before bed and waking up over 300 is like a hangover. Everything hurts and I'm chugging water