#terfenadine

[queerism1969]

Notable transgender people from history

Here's the list I put together for when people on non-trans subreddits claim we didn't exist until recently:

Ashurbanipal (669-631BCE) - King of the Neo-Assryian empire, who according to Diodorus Siculus is reported to have dressed, behaved, and socialized as a woman.

Elagabalus (204-222) - Roman Emperor who preferred to be called a lady and not a lord, presented as a woman, called herself her lover's queen and wife, and offered vast sums of money to any doctor able to make her anatomically female.

Kalonymus ben Kalonymus (1286-1328) - French Jewish philosopher who wrote poetry about longing to be a woman.

Eleanor Rykener (14th century) - trans woman in London who was questioned under charges of sex work

[Thomas(ine) Hall](https://en.wikipedia.org/wiki/Thomas(ine)_Hall) - (1603-unknown) - English servant in colonial Virginia who alternated between presenting as a woman and presenting as a man, before a court ruled that they were both a man and a woman simultaneously, and were required to wear both men's and women's clothing simultaneously.

Chevalier d'Eon (1728-1810) - French diplomat, spy, freemason, and soldier who fought in the Seven Years' War, who transitioned at the age of 49 and lived the remaining 33 years of her life as a woman.

Public Universal Friend (1752-1819) - Quaker religious leader in revolutionary era America who identified and lived as androgynous and genderless.

Surgeon James Barry (1789-1865) - Trans man and military surgeon in the British army.

Berel - a Jewish trans man who transitioned in a shtetel in Ukraine in the 1800's, and whose story was shared with the Jewish Daily Forward in a 1930 letter to the editor by Yeshaye Kotofsky, a Jewish immigrant in Brooklyn who knew Berel

Mary Jones (1803-unknown) - trans woman in New York whose 1836 trial for stealing a man's wallet received much public attention

Albert Cashier (1843-1915) - Trans man who served in the US Civil War.

Harry Allen (1882-1922) - Trans man who was the subject of sensationalistic newspaper coverage for his string of petty crimes.

Lucy Hicks Anderson (1886–1954) - socialite, chef and hostess in Oxnard California, whose family and doctors supported her transition at a young age.

Lili Elbe (1882-1931) - Trans woman who underwent surgery in 1930 with Dr. Magnus Hirschfeld, who ran one of the first dedicated medical facilities for trans patients.

Karl M. Baer (1885-1956) - Trans man who underwent reconstructive surgery (the details of which are not known) in 1906, and was legally recognized as male in Germany in 1907.

Dr. Alan Hart (1890-1962) - Groundbreaking radiologist who pioneered the use of x-ray photography in tuberculosis detection, and in 1917 he became one of the first trans men to undergo hysterectomy and gonadectomy in the US.

[Louise Lawrence](https://en.wikipedia.org/wiki/Louise_Lawrence_(activist)) (1912–1976) - trans activist, artist, writer and lecturer, who transitioned in the early 1940's. She struck up a correspondence with the groundbreaking sexologist Dr. Alfred Kinsey as he worked to understand sex and gender in a more expansive way. She wrote up life histories of her acquaintances for Kinsey, encouraged peers to do interviews with him, and sent him a collection of newspaper clippings, photographs, personal correspondences, etc.

Dr. Michael Dillon (1915-1962) - British physician who updated his birth certificate to Male in the early 1940's, and in 1946 became the first trans man to undergo phalloplasty.

Reed Erickson (1917-1992) - trans man whose philanthropic work contributed millions of dollars to the early LGBTQ rights movement

Willmer "Little Ax" Broadnax (1916-1992) - early 20th century gospel quartet singer.

Peter Alexander (unknown, interview 1937) - trans man from New Zealand, discusses his transition in this interview from 1937

Christine Jorgensen (1926-1989) - The first widely known trans woman in the US in 1952, after her surgery attracted media attention.

Miss Major Griffin-Gracy (1940-present) - Feminist, trans rights and gay rights activist who came out and started transition in the late 1950's. She was at Stonewall, was injured and taken into custody, and had her jaw broken by police while in custody. She was the first Executive Director of the Transgender Gender Variant Intersex Justice Project, which works to end human rights abuses against trans/intersex/GNC people in the prison system.

Sylvia Rivera (1951-2002) - Gay liberation and trans rights pioneer and community worker in NYC; co-founded STAR, a group dedicated to helping homeless young drag queens, gay youth, and trans women

Marsha P. Johnson (1945-1992) - Gay liberation and trans rights pioneer; co-founded STAR with Sylvia Rivera

[macgyvermedical]

Hi! For the pharmaceutical history: I'd like to know more about the history of loratadine. (If that one's boring, I'm sorry - I'm just really curious about allergy medicine history) Hope you're doing good!

Loratadine (Claritin, approved in 1988) was not the first nonsedating (second generation) antihistamine, but it wanted to be. Terfenadine (Seldane, from a competing manufacturer, approved in 1985) was the first. And because terfenadine got to the FDA just ahead of loratadine, loratadine was put on the FDA's backburner, delaying it's entrance to the market by over 3 years.

Loratadine made up for this by marketing the absolute sh*t out of their drug. If you were watching TV or reading magazines in the late 80s or early 90s, you probably remember. Loratadine was prescription only at the time. But direct-to-consumer advertising still had rules. By the early 1990's you couldn't have an ad that was selling a drug without a list of the side effects. And when you're trying to sell a non-drowsy antihistamine on the merit that it was non-drowsy, having to list the fact that the #1 side effect was still drowsiness didn't go over so well. This wasn't an issue in print so much- you could make the print about the side effects as small as you wanted, and who was going to read 3-pt font? But you couldn't do the same in a TV spot.

This was a problem for the company selling Claritin. So instead of making TV ads for the DRUG Claritin, they decided to sell the BRAND Claritin instead. So the ads just never said that Claritin was a drug, or what it did. They just said things like "Claritin is the non-drowsy brand" and "ask your doctor about Claritin" and the ever popular "live Claritin clear."

"But Ross," you might be asking yourself, "whatever did Claritin do to sell to the previously untapped market of children as drug consumers? I simply must know!" Well, you're in luck, because in 1998, and this is real, they released a 12-page Batman comic centered around Tim Drake having allergies that interfered with his crimefighting career. All other antihistamines made him too drowsy, so thank goodness he went to his doctor to get a prescription for Claritin!

You might also be wondering how insurance companies felt about having to pay for on-patent allergy medication (spoiler alert, they hated it, just like they hate paying for everything). Well, also in 1998, Anthem (the insurance company) petitioned the FDA to approve Claritin as an over-the-counter medication. If a medication was over the counter, they wouldn't have to pay for the medication, nor would they have to pay for the associated doctor's visits to get prescriptions for the medication. The FDA approved the petition, but it wasn't until 2002, when the patent had expired, that the company that made Claritin finally released an over the counter version. Even today, though, over the counter loratadine is so much more expensive than other second generation antihistamines. I couldn't figure out why this is, or why people keep buying brand name Claritin when there's like 5 other cheaper non-drowsy antihistamines to choose from.

Finally, I'll wrap up by telling you about the fate of terfenadine. See, turns out terfenadine is super cardiotoxic, especially when combined with certain antibiotics. It got taken off the market in 1997 after quite a few people died. It was replaced with fexofenadine, a metabolite of terfenadine without the cardiotoxic properties.

[lilithism1848]

[missmisandrytabletalk]

can we get some momentum going against tumblr user patricia-taxxon please.... she's a trans woman who likes to sexually roleplay as a teenage girl and as a puppy in diapers and gets off to the idea of incestuous sexual abuse

omg that's some horrendous shit! I wonder what TRAs have to say about this now. 🤢

[bigshot-furbiestm]

[omorinovaau]

SPAM THE TERF TAG WITH NON-TERF STUFF!

I have a task for you guys.

spam the radfem/terf tags. make it unusable. spam it with whatever you want, until it's just fandom, trans stuff, memes, or literally whatever. share blocklists, call out terfs, do whatever you can to spam the tag full of non-terf stuff.

you guys got this 👍

[medicomunicare]

Anti-itches to the rescue: unconventional and repurposing fraternizing against leukemia

Anti-itches to the rescue: unconventional and repurposing fraternizing against leukemia

Acute myeloid leukaemia (AML) is a clinically and biologically heterogeneous disease characterized by the accumulation of immature transformed myeloid progenitors in bone marrow. Although huge step forward have been achieved in improving outcomes for AML patients, the standard therapy for most subtypes of newly diagnosed AML has remained practically unchanged over the past 40 years, and the…

[pharmaffiliatesanalytics]

CAS No : 115-46-8 | Product Name : Terfenadine - Impurity I | Chemical Name : Diphenyl(piperidin-4-yl)methanol | Pharmaffiliates

Buy highly pure Terfenadine - Impurity I, CAS No : 115-46-8, Mol. Formula : C18H21NO, Mol. Weight : 267.37, from Pharmaffiliates. Login as registered user for prices, availability and discounts.

[theboyonthehighcastle]

What Radical feminism do to everyone's brains.

[queerism1969]

[lyriumheart]

a te/rf blocklist

faxxmachine austereanastasia queenfallopium destroycoomers ms-gay-frogs callme-alma ancient-bruises-ancient-moon bulbasaurdyke rf-times radredrose absoluteunitpussy terfenadin pronoun-fucker heylookatthiscoolshit shes-the-original characterfromthebook korydweninterim a-womb-of-ones-own evercelle villanelleisgod

[doctorfoxtor]

the only drug transphobes can use is terfenadine. No matter what illness they have if they need medicine it can only be terfenadine. Get torsades and die bitch

[theboyonthehighcastle]

A little reminder. Radfems aren't humans.

So this woman has a three year old son and she put sprinkles on his dinner to make him think it was dessert so he'd eat it

In between the dumpster fire of comments that argued over whether this was a good idea or not, were these two comments

Now for this first one I can't be 100% sure that she's being serious (I can't distinguish what is and isn't satire/sarcasm sometimes tbh) but I'm inclined to believe this is just because the Internet is crazy and there are all kinds of people out there

Even if she wasn't being serious, two people liked it which is just as wild to me

Why are we gendering food??

I'm going to remind you all that this is a 3 year old little boy we're talking about

And this woman has already made up her mind of the kind of person he's going to be

[missmisandrytabletalk]

Your honest opinion should all men be in chastity? Not just single men every male.

sure why not but the chance of y'all being a threat is still there. practising celibacy wouldn't really create a huge difference. it'll just make you a hermit who jerks off to porn in their gloomy dark huts. and considering how horny your species can get, y'all would legit sexually assault/rape any woman or a child you'd encounter when set loose.

[siglerprescriptiondrugcards]

Fluvoxamine Maleate

Brand Name: Luvox

Generic Available

Common Dosage Forms:

Tablets: 25 mg, 50 mg, 100 mg

Capsules, Extended-Release: 100 mg, 150 mg

FDA Indications/Dosages:

Treatment of Obsessive Compulsive Disorder*

Adults: Start with 50 to 100 mg once daily at bedtime. Increase dosage as needed no sooner than weekly up to a maximum of 300 mg per day. Tablets are usually given in two separate doses and ER capsules in a single bedtime dose.

Pediatric (8-17 years of age): Start with 25 mg once daily. Increase dosage as needed no sooner than weekly up to a maximum of 200 mg per day. Daily doses over 50 mg should be given in two separate doses.

*OCD is characterized by recurrent and persistent ideas, thoughts, or images (obsessions) that are ego-dystonic and/or repetitive, purposeful, and intentional behaviors (compulsions) that are recognized by the patient as excessive or unreasonable.

Monitor: Weight in children and adolescents

Pharmacology/Pharmacokinetics: Fluvoxamine’s actions are thought to be due to an inhibition of CNS neuronal uptake of serotonin (5HT). It has no significant affinity for adrenergic, cholinergic, GABA, dopaminergic, histaminergic, benzodiazepine, or serotonergic receptors. Terminal elimination undergoes extensive first-pass metabolism (oxidative demethylation and deamination) to form less active metabolites. Excretion occurs both through the urine and through the feces. About 80% of fluvoxamine is bound to plasma proteins. It is a substrate for P450 hepatic isoenzymes CYPIA2, CYPIIC9, and CYPIIIA4.

Drug Interactions: Use in combination (within 14 days) with MONOAMINE OXIDASE INHIBITORS (MAOI) may cause serious or even fatal reactions. May increase the effects of TERFENADINE, CISAPRIDE, THEOPHYLLINE, WARFARIN, TIZANIDINE, RAMELTEON, diazepam, alprazolam, midazolam, triazolam, carbamazepine, clozapine, amitriptyline, clomipramine, imipramine, and methadone. Lithium and tryptophan may enhance its effects.

Contraindications/Precautions: Do not use within 14 days of therapy with a MAOI. Do not use with terfenadine or cisapride. INCREASED RISK OF SUICIDAL THINKING AND BEHAVIOR IN CHILDREN, ADOLESCENTS, AND YOUNG  ADULTS TAKING ANTIDEPRESSANTS FOR MAJOR DEPRESSIVE DISORDER AND OTHER PSYCHIATRIC DISORDERS. Use with caution in patients with renal or hepatic dysfunction. Patients should be careful when performing tasks which require alertness. Fluvoxamine is secreted in breast milk. Pregnancy Category C.

Adverse Effects: Nausea (40%), headache (22%), insomnia (21%), somnolence (22%), asthenia (14%), GI complaints (11%), dry mouth (14%), nervousness (12%), dizziness (11%), sweating (7%), delayed ejaculation (8%).

Patient Consultation:

Continued therapy may be needed to show noticeable improvement. Do not stop therapy before consulting with a physician.

Use caution when performing tasks that require mental alertness.

Store in a cool, dry place away from sunlight and children.

Contact a physician if the above side effects are severe or persistent.

If a dose is missed, skip it and return to normal dosing schedule.

[gncrevan]

Your Guide to the Most Common Antihistamines

H1-Antihistamines

These are what we commonly think of as antihistamines, also known as anti-allergens.

First Generation H1-antagonists are precursors to antipsychotics. They often have a psychotropic effect and tend to calm you down in low doses. Work well as antiemetics against nausea and vomiting. High doses may in some cases cause hallucinations. Often very sedating.

Diphenhydramine aka Benadryl: for some reason really popular in the U.S.? Other countries mainly use it to aid sleep, or to treat an anaphylactic shock. Known to be hallucinogenic in high doses or when mixed with alcohol. IT IS NOT A COLD MEDICINE. ANTIHISTAMINES DON'T HELP AGAINST INFECTIONS.

Dimenhydrinat aka Draminate, Dramamime: a combination of Benadryl and Theophyllin, which is a bronchodilator. Used to treat nausea, vomiting and motion sickness. Due to its highly sedating effect, also used to aid sleep. Like Benadryl, it can cause hallucinations in high doses.

Dimetindene aka Fenistil: very popular in topical cream to treat sunburn or insect bites. In cases where a person doesn't react well to second generation meds, this is usually the go-to alternative, as it is not particularly psychoactive. However, it tends to be very sedating. Most commonly used in relatively high doses either orally or IV to treat anaphylaxis. Can interact badly with tri-cyclical antidepressants!

Second Generation H1-antagonists are safer and cannot be overdosed easily as they don't have extreme side effects. They are less sedating and not psychotropic. If you don't happen to react badly to these, they're the best option available to treat allergies, histamine intolerance or mast cell disease.

Cetirizine aka Zyrtec: your average over-the-counter allergy med. Slightly sedating, but highly effective. Treats hayfever, urticaria, dermatitis etc. Generally advised to be taken before bedtime.

Loratadine aka Claritin: also generally over the counter. Said to not be sedating at all/have no effects on the central nervous system. Treats allergies, eczema etc.

Fexofenadine aka Allegra: sometimes also called a third generation med cause it's technically a derivate of Terfenadin. The latter had a risk of cardiovascular problems that is much reduced in Fexo. It's also not particularly sedating in my experience. I take copious amounts of this as it's a staple to treat MCAS/mastocytosis. It's not available over the counter.

Ketotifen aka Zaditor: also acts as a mast cell stabilizer in addition to being an antihistamine. Treats mast cell disorders, asthma attacks, anaphylaxis and various allergies.

H2-Antihistamines

These decrease stomach acid production (kinda like PPI) and are commonly used to treat reflux, gastritis and other acid-related stomach issues. Since PPI like omeprazole have been found more effective, H2-antagonists have generally fallen out of use, except in therapy for mast cell diseases and in cases where a PPI is not tolerated.

Ranitidine aka Zantac: appears to be the most popular one. Can sometimes cause dizziness, sleepiness, tachycardia and malabsorption.

Cimetidine aka Tagamet: no observable side effects or possibility to overdose. Can interact negatively with tri-cyclical antidepressants, blood pressure medicine, opioids, and a lot of other drugs.

H3-Antihistamines

Kinda rare, sometimes used to treat vertigo and Morbus menière but the effectiveness seems to be controversial.

H4-Antihistamines

As far as I can tell, these are not yet in use. They appear to have anti-inflammatory properties that are being examined.

General Note

All antihistamines can negatively affect your cardiovascular system, cause headaches, and dryness of the mouth. They are also completely broken down via your liver, so as with any medication, if you take it over an extended amount of time, get regular blood checks. That said, especially the newer generations are relatively safe and have few to no side effects. Every medication comes with a certain risk, but antihistamines are in general a lot less risky than for example pain meds, asthma meds, blood pressure meds etc.

However, antihistamines can only treat things that are allergic or autoimmune! They are not beneficial against infections, in fact they actually suppress your immune system. This might be helpful in some cases, for example to not make you throw up, as this is controlled by histamine, but it can only alleviate some symptoms in those cases. If you have allergic inflammations, it can help, especially if used directly on your skin, in your nose or eye, and it can counteract allergic reactions in your body, but it cannot fight bacteria or a virus. Please don't treat your cold with benadryl! Also please don't treat your allergies with benadryl if you have other options, second gen meds are much safer!