#tackle leukemia cancer

[barrywhite01]

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Top Health Related Stories of 2023

A Year-End Review of Top Medical Stories of 2023

2023 was a year of contrasting narratives in the realm of health. While groundbreaking advancements in science and technology offered glimpses of a brighter future, persistent challenges such as climate change, pandemics, and health disparities continued to cast long shadows. As we prepare to close out the year, let’s delve into the ten most impactful health stories that shaped 2023:

1. Hope from the “Geneva Patient”: A Potential HIV Cure?

A beacon of hope emerged in the fight against HIV/AIDS with the case of the “Geneva Patient,” a man who became the third person in history to be functionally cured of the virus after undergoing a stem cell transplant for leukemia. While not a universal solution, this case offers a crucial proof of concept for utilizing stem cell therapies in HIV treatment and paves the way for further research in this promising field.

2. GLP-1 Agonists: Reshaping Weight Management and Heart Health

2023 witnessed the rise of GLP-1 receptor agonists like semaglutide as game-changers in both weight management and cardiovascular disease prevention. Studies like SELECT demonstrated the drug’s ability to not only significantly reduce weight but also lower mortality risks in people with obesity and established cardiovascular disease. This marks a significant shift in the paradigm of weight management, moving beyond solely calorie restriction and towards addressing the underlying physiological factors contributing to weight gain and cardiovascular health.

3. COVID-19: New Variants, Ongoing Battles, and Lingering Long COVID

While the initial panic of the pandemic may have subsided, COVID-19 remained a dominant force in global health throughout 2023. The emergence of new variants like JN.1, coupled with vaccine hesitancy and waning immunity, led to surges in cases in many regions. Additionally, the long-term effects of COVID-19, known as Long COVID, continued to impact millions, highlighting the need for further research and treatment options to address this complex and multifaceted condition.

4. AI Takes Center Stage in Healthcare: Revolution or Risk?

Artificial intelligence (AI) made significant strides in the healthcare landscape in 2023. From assisting with medical diagnoses and surgeries to predicting patient outcomes and developing personalized treatment plans, AI’s potential to transform healthcare is undeniable. However, concerns regarding ethical considerations, data privacy, and potential job displacement also emerged, sparking meaningful conversations about the responsible integration of AI into healthcare systems.

Read About Other Important Health News

Top Medical Stories of 2023

5. Gene and Cell Therapy: Approaching Reality for Chronic Diseases

Gene and cell therapies, once considered futuristic medical marvels, inched closer to clinical reality in 2023. The FDA approval of the first CRISPR gene editing treatment for sickle cell disease marked a significant milestone, with similar therapies for other genetic disorders on the horizon. Additionally, progress was made in using gene-modified CAR-T cells to treat various cancers, showcasing the immense potential of these groundbreaking technologies in tackling previously untreatable diseases.

6. Measles Makes a Comeback: A Stark Reminder of Vaccine Importance

A concerning 40% increase in global measles deaths in 2023 served as a stark reminder of the importance of routine vaccinations. Factors like vaccine hesitancy, misinformation, and disruptions in healthcare due to the pandemic contributed to this rise, highlighting the need for renewed focus on vaccine education and access, particularly in vulnerable communities.

7. Mental Health in the Spotlight: Addressing the COVID-19 Fallout

While physical health concerns dominated the early stages of the pandemic, 2023 saw a growing awareness of the mental health toll of COVID-19. Social isolation, job losses, and ongoing uncertainty exacerbated existing mental health challenges, leading to increased rates of depression, anxiety, and substance abuse. Recognizing the importance of mental health, initiatives to expand access to mental health services and address the stigma surrounding mental illness gained momentum.

8. Climate Change and Health: An Inseparable Link

The connection between climate change and health became increasingly evident in 2023. Extreme weather events like heatwaves, floods, and wildfires displaced communities, destroyed infrastructure, and threatened food security, exposing vulnerable populations to increased health risks. This underscored the urgency of addressing climate change not just as an environmental issue but also as a public health crisis, requiring a concerted effort from policymakers, scientists, and individuals to mitigate its impact on human health and well-being.

9. Antimicrobial Resistance: A Ticking Time Bomb

The rising tide of antimicrobial resistance (AMR) casts a dark shadow over 2023, posing a potentially catastrophic threat to global health. The overuse and misuse of antibiotics, fueled by factors like self-medication, inadequate diagnostic practices, and lack of access to clean water and sanitation, led to the emergence of “superbugs” — bacteria resistant to existing antibiotics, rendering common infections potentially untreatable.

The World Health Organization (WHO) estimates that AMR claims over 700,000 lives annually, a figure projected to rise to 10 million by 2050 if left unchecked. This alarming statistic paints a grim picture of a future where even minor infections could become life-threatening, crippling healthcare systems and jeopardizing advancements in surgery, cancer treatment, and other medical procedures that rely on the effectiveness of antibiotics.

Combating AMR demands a multi-pronged approach:

Investing in Research and Development: Fostering research into new antibiotics and alternative antimicrobials, alongside exploring innovative strategies like phage therapy and antimicrobial peptides, is crucial to stay ahead of the evolving resistance mechanisms of bacteria.

Promoting Antibiotic Stewardship: Implementing stricter regulations on antibiotic use in healthcare settings, coupled with educational campaigns promoting responsible antibiotic use by the public, are essential to curb unnecessary prescriptions and reduce the selection pressure that drives the emergence of resistant strains.

Improving Sanitation and Hygiene: Addressing the root causes of infection transmission through improved sanitation facilities, access to clean water, and hygiene education, particularly in resource-limited settings, can significantly prevent the need for antibiotics in the first place.

International Collaboration: AMR transcends national borders, requiring a global response. Fostering collaborative initiatives between governments, scientists, pharmaceutical companies, and public health agencies is crucial to develop and implement effective solutions on a global scale.

The year 2023 served as a wake-up call, underscoring the urgency of tackling AMR before it’s too late. By prioritizing research, promoting responsible antibiotic use, and addressing underlying sanitation issues, we can work towards a future where infections remain treatable, and the miracle of antibiotics continues to safeguard human health.

10. Health Equity: Striving for a Level Playing Field

Despite advancements in medical technology and treatments, 2023 highlighted the persistent issue of health disparities based on factors like race, socioeconomic status, and geographic location. Indigenous communities, people of color, and low-income individuals continued to face significant barriers to accessing quality healthcare, leading to higher rates of chronic diseases, preventable deaths, and lower life expectancy compared to their more privileged counterparts.

These disparities stem from a complex interplay of social, economic, and political factors, including:

Social Determinants of Health: Factors like poverty, food insecurity, lack of education, and inadequate housing significantly impact health outcomes, creating a vicious cycle of disadvantage.

Discrimination and Implicit Bias: Racial and ethnic disparities in healthcare access and treatment are often exacerbated by unconscious bias among healthcare providers, leading to inequitable care and poorer health outcomes for marginalized communities.

Limited Access to Resources: Rural communities and underserved urban areas often lack adequate healthcare infrastructure, qualified healthcare professionals, and access to specialized services, further widening the health equity gap.

Addressing these disparities necessitates a multifaceted approach:

Social Policy Interventions: Implementing policies that address poverty, inequality, and access to basic necessities can create a healthier environment for all and mitigate the social determinants of health.

Cultural Competency Training: Educating healthcare professionals about cultural sensitivity and implicit bias can help reduce discriminatory practices and improve healthcare delivery for diverse populations.

Community-Based Interventions: Empowering communities through health education, outreach programs, and improved access to primary care services can empower individuals to take charge of their health and bridge the access gap.

Targeted Investments: Directing resources towards underserved communities, including expanding telehealth services and mobile clinics in rural areas, can improve healthcare access and address specific health needs of marginalized populations.

2023’s health stories were not just chronicles of progress and setbacks, but also calls to action. From tackling the looming threat of AMR to striving for health equity, these stories underscored the challenges and opportunities facing global health in the years to come. By prioritizing research, promoting responsible practices, and addressing entrenched inequalities, we can collectively build a healthier future for all, where access to quality healthcare is not a privilege, but a fundamental right for every individual.

Sources:

1. Hope from the “Geneva Patient”: A Potential HIV Cure?

Euronews: https://www.france24.com/en/health/20230720-researchers-say-geneva-patient-is-the-sixth-person-with-hiv-in-long-term-remission

2. GLP-1 Agonists: Game Changers for Weight Management and Heart Health

HCPLive: https://www.hcplive.com

3. COVID-19: New Variants, Ongoing Battles, and Lingering Long COVID

U.S. News & World Report: https://health.usnews.com

4. AI Takes Center Stage in Healthcare: Revolution or Risk?

HCPLive: https://www.hcplive.com

5. Gene and Cell Therapy: Approaching Reality for Chronic Diseases

Scientific American: https://www.scientificamerican.com/article/the-biggest-health-and-medicine-stories-of-2023

6. Measles Makes a Comeback: A Stark Reminder of Vaccine Importance

Euronews: https://www.euronews.com/next/2023/07/20/geneva-patient-becomes-first-to-be-cured-of-hiv-after-normal-stem-cell-transplant

7. Mental Health in the Spotlight: Addressing the COVID-19 Fallout

BBC News: https://www.bbc.co.uk/news/explainers-55957105

8. Climate Change and Health: An Inseparable Link

Nature: https://www.nature.com/articles/d41586-023-03804-x

9. Antimicrobial Resistance: A Ticking Time Bomb

World Health Organization: https://www.who.int

10. Health Equity: Striving for a Level Playing Field

National Institutes of Health: https://www.nih.gov

[cancerounds]

How Car T Cell Therapy Is a Hope for Future in Cancer Treatments

When we talk about cancer, we often think about its harsh effects and the burdensome cost of its treatments, especially something as severe as breast cancer. While it's true that treatments like breast cancer therapy come with a significant cost in places like India, there's also a growing sense of hope. This optimism stems from breakthroughs like Car T cell therapy a revolutionary treatment that's bringing new hope to cancer patients worldwide. This article will explore Car T cell therapy's transformative role and why it represents a beacon of hope for the future of cancer treatment.

Unlocking the Power of the Immune System

Our body's immune system is our natural defense against disease. Car T cell therapy leverages this by reprogramming a patient's T cells, a type of immune cell, to recognize and attack cancer cells. This pioneering method is backed up by known oncologists like Dr. Rahul Bhargava, among many more, and offers an entirely new approach to tackling cancer, giving patients renewed hope.

A Revolutionary Approach

Car T cell therapy stands out because it's not a one-size-fits-all treatment. It's personalized for each patient. Doctors take the patient's own T cells, modify them in a lab to recognize cancer cells and reintroduce them into the patient's body. This bespoke approach is part of why Car T cell therapy holds such great promise for the future of cancer treatments.

Cost and Accessibility

No discussion of treatment would be complete without addressing the cost. The cost can be a significant factor in getting your treatment. For example, breast cancer treatment costs in India and places alike can be significant, and new treatments like Car T cell therapy bring with them the hope of more accessible solutions in the future. As this therapy continues to develop and become more widely available, its cost is likely to become more manageable.

Increased Survival Rates

Another significant point to mention is the effect of Car T-cell therapy on survival rates. Initial studies have shown that many patients who didn't respond to other treatments or who experienced a relapse achieved remission with Car T-cell therapy. These encouraging results bring hope of not only survival but also of potential cures for certain cancers.

Promising Results in Various Types of Cancers

Car T-cell therapy has been successfully used in treating certain types of blood cancers, including some types of lymphomas and leukemia. But the real hope lies in its potential to treat other cancers as well. With ongoing research and clinical trials, scientists are optimistic about expanding its use to a broader range of cancers in the near future.

Conclusion

As we look to the future of cancer treatment, therapies like Car T cells are clearly leading the way. They represent a new hope for patients, a promise of more effective, personalized treatments. While cost is still a factor, the hope these treatments bring is invaluable. As we navigate these developments, consultancy services like Cancer Rounds at Fortis Gurgaon can be a valuable resource, providing essential guidance to patients and their families on their cancer journey. You can visit their site to know more: - cancerrounds.com.

[thxnews]

Global Initiative: Enhancing Childhood Cancer Survival

  Childhood Cancer Medicines Still Inaccessible in Low-Income Countries

During his weekly press briefing in Geneva, Tedros Adhanom Ghebreyesus, the Director-General of the UN World Health Organization (WHO), revealed that only a quarter of low-income countries currently provide coverage for childhood cancer medicines through public benefits. This lack of accessibility has dire consequences for children and families, subjecting them to significant suffering, financial hardship, or worse, putting them at risk of receiving substandard and falsified medications. Consequently, the survival rate for children battling cancer in these countries is distressingly low, standing at less than 30 percent. This is in stark contrast to the impressive 90 percent survival rate for children in high-income countries.  

WHO's Global Initiative for Childhood Cancer

To tackle this pressing issue, the WHO, in partnership with the St. Jude Children's Research Hospital based in the United States, a renowned non-profit pediatric treatment and research facility specializing in leukemia and other cancers, launched the Global Initiative for Childhood Cancer back in 2018. The overarching goal of this initiative is to achieve a minimum 60 percent survival rate for childhood cancer patients in low and middle-income countries by the year 2030. Specifically focusing on addressing six highly curable types of cancer, which collectively represent more than half of all childhood cancer cases, this initiative strives to make a significant impact on improving survival rates worldwide.   Access to Quality-Assured Medicines at No Cost In December 2021, the WHO and St. Jude jointly initiated a global program with the aim of improving access to childhood cancer medicines. Mr. Tedros emphasized that the primary objective of this program is to provide universal and sustained access to quality-assured essential cancer medicine for children in developing economies, free of charge. This vital effort aims to relieve the burden of exorbitant medical expenses on vulnerable families and ensure that every child has the best chance of survival and recovery.  

WHO's New Essential Medicines List

Today, the WHO announced a significant update to the Essential Medicines List and the Essential Medicines List for Children. Among the new additions are crucial cancer medicines, alongside treatments for multiple sclerosis, infectious diseases, and cardiovascular conditions, among others. These additions are expected to have a profound public health impact worldwide without jeopardizing the health budgets of low and middle-income countries.  

Alarming Heat-Related Deaths in Europe

Amid the ongoing heatwave across the northern hemisphere, the WHO has reported distressing news about Europe. An estimated 61,000 people lost their lives due to heat-related causes last month, highlighting the severity of heat stress on human health and well-being.   Heat Stress and its Health Implications Heat stress refers to the body's inability to cool itself efficiently, leading to exhaustion or heat stroke. The WHO has linked heat stress to the exacerbation of various health conditions, including cardiovascular, respiratory, and kidney diseases, as well as mental health problems.   Vulnerable Populations at Risk Director-General Tedros Adhanom Ghebreyesus expressed deep concern about the impact of extreme weather conditions on the health of vulnerable populations. He particularly highlighted those living in conflict-affected areas or displaced communities, where access to safe water, sanitation, cooling facilities, and medical supplies is limited or non-existent.   Urgent Need for Precautionary Measures In response to this pressing issue, Mr. Tedros called on governments to establish early-warning and response systems, develop strategies tailored for both the general population and vulnerable groups, and create effective communication plans. Additionally, he underscored the urgency of reducing greenhouse gas emissions to protect the planet and safeguard all forms of life. By doing so, the international community can take proactive steps toward mitigating the devastating impacts of extreme heat and ensuring the well-being of people worldwide.   Sources: THX News & United Nations. Read the full article

[mediwinpharma]

Top Demand Drug companies in India in the Last Decade

Over the past decade, the demand for drug companies in India has significantly increased, reflecting the country's evolving healthcare industry. In fact, a report by Statista indicates that the Indian healthcare and pharmaceuticals sector is anticipated to experience an extraordinary growth rate of 754% between 2017 and 2060.

As India emerges as a major player in the pharmaceutical industry, it is critical to understand the demand for various drugs in the country. It provides valuable insights into the health concerns of the people, the shifting demographics, and the evolving medical requirements.

So, read the article below to gain in-depth knowledge about high-demand drugs in India and the factors influencing this demand. This knowledge can help drug companies to focus their R&D and production to cater to the specific needs of the Indian market.

Top 8 Demand Drugs in India

Some of the best drugs in India and their uses are given below:

1. Humira

Humira (adalimumab) is a widely used biological medication known for its effectiveness in treating various conditions. It functions as a tumor necrosis blocker, which helps suppress the immune system by blocking the activity of factor-α (TNF). TNF is a protein associated with inflammation and autoimmune diseases.

Uses

Treats rheumatoid arthritis in adults.

Indicated for adults with hidradenitis suppurativa (HS).

Tackles chronic plaque psoriasis.

Treats non-infectious intermediate, posterior, and panuveitis.

Approved for adult patients with active ulcerative colitis.

Used to reduce signs and symptoms of active ankylosing spondylitis.

2. Keytruda

Keytruda is a cancer medication that contains the active substance pembrolizumab. It belongs to a class of drugs known as immune checkpoint inhibitors. Keytruda blocks a protein called PD-1 in immune cells. This allows the immune system to recognize and attack cancer cells.

Uses

Treats advanced or metastatic melanoma.

Treats advanced NSCLC.

Treats children with classical Hodgkin lymphoma.

Treats advanced renal cell carcinoma.

Used in combination with chemotherapy or other cancer medicines to treat oesophageal cancer.

Prevents blood clots in cases like broken bones, immobility, surgeries, etc.

3. Eliquis

Eliquis is a prescription medication that belongs to the class of drugs known as anticoagulants or blood thinners. It is considered an anticoagulant because apixaban is its active ingredient. Eliquis is FDA-approved for treating and preventing dangerous blood clots that can block blood vessels in the body.

Uses

Treats deep vein thrombosis (DVT).

Prevents stroke.

Treats pulmonary embolism (PE).

Reduces the risk of systemic embolism.

Avoids thromboembolic events in individuals with chronic kidney disease.

Used as an anticoagulant therapy during cardiac catheterization procedures

4. Revlimid

Revlimid is a medication that contains the drug lenalidomide. It is a thalidomide analog, an immunomodulatory drug (IMiD) with various putative molecular targets and biological effects. Revlimid is primarily used to treat multiple types of cancers affecting blood cells.

Uses

Used in combination with dexamethasone for the treatment of multiple myeloma.

Used as maintenance therapy after an autologous hematopoietic stem cell transplant (auto-HSCT).

Treats lymphoplasmacytic lymphoma.

Used off-label for the treatment of systemic light-chain amyloidosis.

Tackles myelodysplastic syndromes.

Used in combination with rituximab to treat follicular and marginal zone lymphoma.

5. Imbruvica

Imbruvica is a medication available in tablet and capsule forms that are taken orally once a day. Its active ingredient is ibrutinib. Ibrutinib works by inhibiting specific proteins in cancer cells, slowing their growth, and preventing the spread of cancer.

Uses

Treats mantel cell lymphoma (MCL).

Treats chronic lymphocytic leukemia (CLL).

Tackles small lymphocytic lymphoma (SLL).

Treats waldenström's macroglobulinemia (WM).

Manages chronic graft versus host disease (cGVHD).

Prescribed off-label to diffuse large B-cell lymphoma (DLBCL).

6. Stelara

Stelara is a highly effective medication that contains ustekinumab. Ustekinumab is a monoclonal antibody derived from immune system cells. It is specifically designed to target and alleviate the symptoms of various inflammatory conditions associated with immune system dysfunction.

Uses

Provides relief for people suffering from this autoimmune skin condition.

Treats psoriatic arthritis for adults.

Deals with the challenges of moderate to severe Crohn's disease.

Treats adults with this type of inflammatory bowel disease.

Used off-label in the treatment of active systemic lupus erythematosus.

Used for investigational purposes of hidradenitis suppurativa.

7. Xarelto

Xarelto (rivaroxaban) is a medication also classified as a blood thinner. It works by inhibiting the activity of Factor Xa, an enzyme involved in blood clot formation. While Xarelto does not thin the blood, it helps prevent the formation of blood clots and reduces the risk of strokes and systemic embolisms in certain medical conditions.

Uses

Reduces the risk of stroke and systemic embolism with nonvalvular atrial fibrillation.

Treats and maintains drugs for deep vein thrombosis (DVT).

Reduces the risk of recurrence of pulmonary embolism.

Prevents blood clot formation in patients suffering from heart failure, respiratory disease, or infectious diseases.

Used as a prophylactic treatment to prevent blood clots in patients with cancer.

Prevents the recurrence of ischemic events, such as heart attacks or peripheral artery disease

8. Opdivo

Opdivo is an immunotherapy drug that belongs to a class of medications known as checkpoint inhibitors. It targets the PD-1 receptor, found on the surface of T cells, the immune cells responsible for fighting cancer. PD-1 helps regulate immune responses in healthy tissues, but cancer cells can exploit this mechanism to evade immune attacks. Opdivo blocks the interaction between PD-1 and PD-L1/PD-L2 molecules in cancer cells. This blockage enables T cells to recognize and destroy cancer cells effectively.

Uses

Treats advanced melanoma.

Treats non-small cell lung cancer.

Used in combination with ipilimumab for newly diagnosed malignant pleural mesothelioma.

Treats adult patients with classical Hodgkin lymphoma.

Treats patients with recurrent or metastatic head and neck squamous cell carcinoma.

Treats with microsatellite instability-high (MSI-H) or mismatch repair-deficient (dMMR) metastatic colon.

Factors that Impact the Demand for the Drugs

Here are four key factors that impact the demand for drugs:

1. Disease Prevalence and Epidemiology

The prevalence of diseases and their impact on the population greatly influence the demand for drugs. The burden of chronic diseases, or infectious outbreaks, shapes the market for specific medications to treat and manage these conditions.

2. Demographic Changes

Changing demographics, such as aging populations and urbanization, play a crucial role in drug demand. Different age groups have varying healthcare needs, and understanding demographic shifts helps target drug development and delivery strategies accordingly.

3. Economic Factors

Economic factors, including income levels, affordability, and healthcare expenditures, substantially impact drug demand. If medicines are expensive or not affordable, people may struggle to access their prescribed treatments. The cost and accessibility of medications greatly affect the choices people make and their ability to follow through with the necessary treatments.

4. Government Policies and Regulations

Regulatory frameworks, pricing regulations, reimbursement policies, and intellectual property rights all affect the availability, accessibility, and affordability of medicines. This further influences its demand in the market. Understanding and navigating these factors is crucial for ensuring that drugs are accessible and affordable to those who need them.

The Bottom Line

In conclusion, understanding the demand for drugs in India is vital for pharmaceutical companies, policymakers, and healthcare providers. By now, you must be aware of the factors that significantly impact drug demand. By aligning their strategies with these factors, stakeholders can meet the evolving healthcare needs of the Indian market effectively.

Moreover, if you're looking for a trusted name in the pharmaceutical industry for reliable and high-quality medications, consider Mediwin Pharmaceuticals. They have been one of the top pharma companies serving India since 1990. It is among the top pharmaceutical manufacturing companies in Ahmedabad because they facilitate effective medications for chronic conditions, specialized therapies, and preventive care.

So, visit Mediwin’s website today to discover its diverse product portfolio!

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[arunvillivalam]

Top 5 Proven Ways To Care For Multiple Myeloma

Multiple Myeloma, a kind of blood cancer, can be devastating for the patient and their caregivers. It is the third most common blood cancer after lymphoma and leukemia and the most common type of plasma-cell cancer. 

The nature of myeloma is that it keeps changing with time, and so do the needs of the patient. It’s natural for the patient and their loved ones to go through emotional and physical turmoil because of the turbulent nature of myeloma. One rule of the thumb is to cultivate a mindset that accepts change as the norm.

In this article, we help you understand the condition better, so you can take better care of yourself and stay on top of managing myeloma. 

What Is Multiple Myeloma? 

Multiple myeloma is a cancer that’s related to the plasma cells, i.e. the white blood cells (WBC) that are part of your immune system. WBCs produce antibodies that fight infection. Plasma cells grow in the bone marrow, the spongy tissue in the center of your bones.  

Myeloma occurs when the bone marrow produces too many abnormal or cancerous plasma cells that crowd out the healthy plasma cells. The abnormal, cancerous plasma cells make monoclonal protein or M protein, an unwanted antibody protein with no purpose in the body, except to damage it. The cancerous cells clump together and form bone tumors. 

While myeloma starts in the bone marrow, it can spread to multiple parts of the body. 

What Are The Signs And Symptoms Of Multiple Myeloma? 

There may not be signs of myeloma in the initial states. But you will notice some of the following symptoms in the advanced stages. Watch out for these signs of multiple myeloma. 

Bone pain, especially in your chest and ribs, spine and lower back. 

Frequent infections

Unexplained rapid weight loss

Breathing difficulties

Nausea

Weakness

Tiredness

Mental fogginess

Constipation

Loss of appetite

Excessive thirst

Numbness or tingling sensation in your hands and feet 

Bleeding

Anemia

Fever

Too much calcium in the blood (hypercalcemia)

High levels of protein in the urine

Bone fractures

Kidney damage

You should consult your primary care doctor in Campbell if you have any of the above symptoms. 

What Is The Cause Of Multiple Myeloma? 

There is no known cause of multiple myeloma. However, you may be at a higher risk of myeloma if you meet these conditions:

Advancing age 

Overweight or obese

Male

Family history of multiple myeloma 

Personal history of Monoclonal Gammopathy of unknown significance

Exposure to radiation and harmful chemicals

What Are The Complications Of Multiple Myeloma? 

There are other health complications that are associated with multiple myeloma that include:

Frequent infections

Blood problems such as anemia 

Bone problems such as bone pain, thinning of the bones and broken bones. 

Deteriorated kidney functioning that can lead to kidney failure. 

Diagnosis And Treatment For Multiple Myeloma

Multiple myeloma can be treated when diagnosed early and controlled effectively. Diagnostic tests for myeloma include: 

Blood tests 

Urinalysis

PET CT

X-rays

Bone marrow biopsy 

The doctor will recommend a customized treatment plan based on the patient’s stage of myeloma. It helps in killing cancer cells, tackling bone tumors, managing any kind of infection and reducing inflammation. The treatment options include:

Medications for pain relief

Chemotherapy 

Immunotherapy

Radiation 

Targeted therapy

Stem cell transplant

How To Take Care Of Yourself With Multiple Myeloma 

Multiple myeloma is a progressive condition which worsens with time. If your loved one has multiple myeloma, there will be times when they’ll feel better and times when they’ll feel worse as the symptoms return. 

Here’s what you can do to help your loved one who’s suffering myeloma during their treatment and remission so they can stay healthy. 

Schedule Follow-Up Medical Appointments

When you’re in remission, your doctors and care team will want to observe your health like any changes in your bone pain or looking for any frequent infections.

It’s critical to schedule and attend all your follow-up appointments, which may include blood tests and bone scans to check if your disease is progressing or contained. If your condition is worsening, your doctors will most likely suggest different treatments or follow a different approach to the current treatment plan.

Also, a person with multiple myeloma needs to be regular with their follow-up medical appointments, as they are at a higher risk of getting an infection than those without the condition. Some infections are: 

Urinary tract infections

Blood infection

Pneumonia

Fungal infections or viral infections like influenza 

The doctor will use preventive strategies such as vaccination, medication, and intravenous immunoglobulin (IVIG) to help lower the risk of infections. 

Adapt to your loved one’s changing care needs

Since multiple myeloma is a progressive disease, the needs of your loved one will also change with the symptoms in that particular cycle. Call your doctor immediately when you notice any abnormality or symptoms. 

As treatment changes as per your loved one’s current condition, you’ll need to keep track of all their medications. 

The various medical procedures can be daunting for your loved one with multiple myeloma. Be an emotional support for them and motivate them to prepare and complete all their treatment procedures. You will need to help them with their daily medications and other routine procedures to help them remain healthy. 

Keep the lines of communication open always and talk in a tone that encourages them to open up about how they’re feeling so you can listen and understand their fears and needs. 

Track their progress and all the health changes and discuss this list with the doctor. 

Recover with a balanced diet

Nutrition is a vital part of multiple myeloma recovery.

Eating timely, well-balanced meals during and after the treatment can significantly improve the way your loved one feels. Proper nutrition will give them the strength, vitality and speed up their recovery process. Include high-quality protein to help your loved one’s body and immune system recover and whole grain to help them maintain their energy levels. 

Eating 5-6 small meals throughout the day will help your loved one stay nourished without overeating. Opt for bland instead of spicy and deep-fried foods. Your loved one can have fruits and vegetables to up their antioxidants intake. They can include healthy fats such as olive oil, nuts, seeds, and avocado.

Drink adequate water daily, and avoid excess caffeine. Also, avoid or limit alcohol consumption, as excessive drinking can harm your loved one’s immune system. 

Since unexplained rapid weight loss is a symptom of multiple myeloma, the focus should be on keeping a healthy weight. A balanced diet recommended by the doctor will help your loved one from gaining or losing too much weight. 

Exercise with caution 

Multiple myeloma can put your loved one at risk of mobility problems, falls, and fractures. 

Before they start any physical activity and exercise, it’s best to consult the doctor to assess them. The doctor can recommend a customized exercise plan - the kind of exercises they can do, what they must avoid, how many times to exercise in a week, intensity and duration of the exercise. They can also recommend your loved one to work with a physical therapist. 

Manage stress caused by multiple myeloma  

Stress and myeloma go together, and it can make your loved one anxious as they undergo the treatment. Stress isn’t good, especially for people with myeloma, a cancer that damages the bone marrow, which typically boosts the immune system by making antibody producing cells. Stress can make your loved one’s myeloma worse, as it significantly weakens the immune system. 

While it might be hard for your loved one to lower their stress levels on their own, you can help support them in relieving their anxiety. 

Talking to your doctor’s recommended psychiatrist or professional counselor will help your loved one. A lot of patients see the change in their stress levels in the first week of consultation. Ask them about whether your loved one should take an antidepressant or anti-anxiety medications. 

Your loved one can have a trusted circle of family members and friends with whom they can share their feelings. 

Sleep is essential for having a relaxed mind and better recovery. If your loved one cannot sleep because of anxiety, your doctor might suggest prescription sleeping pills for a certain period. 

Encourage your loved one to take time to destress everyday through deep breathing techniques, meditation, listening to their soothing and uplifting music, and taking a walk. 

Assure them that what their feeling is normal, and this too shall pass once their treatment is over and they're on their healing path. 

Your support can help your loved one manage their multiple myeloma

Living with multiple myeloma can be challenging. Your support can help your loved one with multiple myeloma stay as healthy as possible. 

Discuss with their doctor about their fears and doubts around multiple myeloma and its effect on their life. The best doctor in Campbell can adjust their medication, diet, enhance their electrolyte and fluid intake, and help them find a psychiatrist for boosting their mental health. 

You can support your loved one to go for follow-up medical appointments, eat a well-balanced diet, get regular exercise as recommended by the doctor, quit smoking and alcohol, rest well, take counseling if required to manage stress and depression, and limit contact with people who are sick.

Your love and support will make it easier for your loved one with multiple myeloma to cope and remain positive throughout the treatment journey and remission period. 

[don-lichterman]

Scientists identify new molecular strategies for tackling aggressive form of leukemia -- ScienceDaily

Scientists identify new molecular strategies for tackling aggressive form of leukemia — ScienceDaily

A discovery by researchers at the University of Sussex has the potential to benefit leukemia patients by opening up new treatment strategies for treating the disease. Acute myeloid leukemia (AML) is an aggressive form of leukemia which impacts a type of white blood cell (leukocyte) normally responsible for fighting infection and preventing tissue damage. There are around 3,000 new cases of AML…

[cryovault-india]

Umbilical Cord Blood Preservation in India: What are the basic know-hows?

With the advancement of science, doctors have found a new way to tackle any ailments that your newborn can face later at any stage of their life. And that’s where the concept of umbilical cord preservation comes in. The best stem cell banks in India are implementing the process of cord blood banking for collecting stem cells having life-saving properties and preserving them for future use. The stem cells take the form of certain other cells when they grow.

When you perverse the stem cells from the umbilical cord blood of your newborn, you would be sure that you have the stem cells ready in case of future therapeutic applications. In today’s world, stem cell preservation from umbilical cord blood is used for treating over eighty different types of diseases.

What are the advantages?

Here is a list of certain advantages that you can enjoy when you opt for stem cell baking:

● Successful Transplants

A successful transplant requires a close match of human leukocyte antigen types. Newborns inherit these antigen types from their parents. So, when you bank your child’s cord blood, you are banking their stem cells with these antigens and thereby improves the chances of a potential transplant.

● Treats Serious Diseases

Cord blood has a good content of stem cells that can be morphed into most blood cells. Hence, stem cells can treat diseases that affect the immune system and blood, including metabolic disorders, sickle-cell anemia, certain cancers, and leukemia.

● Easy and Simple

Preserving the cord blood of your baby is a safe and straightforward procedure that immediately takes place after your child’s birth. The whole procedure does not require more than five minutes, and it is also painless. Moreover, once you store the stem cells, you can enjoy their benefits throughout your life.

Having said that, there are multiple life-saving benefits that one can enjoy when you preserve your baby’s umbilical cord blood. Furthermore, when you do it from the best service providers, the costs are also minimal.

Cost of Stem Cell banking

The stem cell banking cost usually depends on two main components.

● The cost of collection, as well as processing, is taken into consideration. The price varies depending on the service provider you choose and the banking option you are looking for: placenta tissue banking or cord blood banking.

● The umbilical cord preservation cost also depends on the storage fees that the service provider charges. Storage fees are usually charged yearly. In most cases, companies offer certain discounts when clients choose the prepaid option.

Wrapping Up

When you store your newborn’s stem cells, you are securing their life and others in the family. Hence, you must choose industry-leading organizations like Cryovault with the most pocket-friendly packages for cord blood banking cost in India. Besides that, they also offer other services that new mothers can significantly benefit from, such as immunization and pregnancy diet chart. For more information regarding their pricing and services, reach out to them at https://www.cryovault.in/contact/.

[justkindaoverhereobsessing]

Ellick Week Day 3

Trigger warning/content warning: serious illness

@ellickweek

_______________

It starts slowly, the worry that builds in Nick’s chest. 

First comes the absences. Ellie Bishop, dedicated federal agent, starts missing days of work. She always has an excuse—her car broke down, she had a family emergency back in Oklahoma, a friend at NSA needed a favor she’s not at liberty to discuss. Nick believes her, at first, but after a while, it becomes too common to be mere coincidence. (He knows better than to believe in coincidences, anyway.)

Then comes the exhaustion. Ellie comes in with shadows under her eyes one morning, and they don’t leave after that. She’s still her generally chipper self, she’s just… muted. Quiet. She’s clearly so tired that she can barely keep her eyes open when she’s sitting still, but she brushes Nick off every time he asks her why.  

Then comes the change in her appearance. She starts wearing her hair in ponytails every day, often with thick headbands around her face. She gets thinner, her already slim figure shrinking and her clothes getting baggier. Again, she sidesteps every question her teammates have for her.

Then—perhaps most worryingly—comes the change in her behavior. She begins to move as if her joints are stiff and the benefit of every step has to be weighed against what it’ll cost her. She stops snacking all the time and eventually Nick realizes that he hasn’t seen her eat a thing in front of him in weeks. 

Finally something happens that he can’t ignore. She can’t evade him after this.

They’re assisting with a drug bust, routine and unconcerning, when a Navy ensign high on meth takes a swipe at Ellie with his knife. She stumbles slightly trying to get out of the way and mostly succeeds, but the knife catches her in the forearm. 

Nick tackles the guy furiously, but the damage is done. 

As soon as he’s got the guy handcuffed and squared away, he goes back to check on his partner. “Ellie, are you alright!?”

She’s sitting where he left her, her jacket balled up and pressed against her skin to staunch the flow of blood. She’s grimacing, but she turns her expression into some approximation of a smile when she sees him watching her. “Yeah, I’m fine. It could have been a lot worse.”

“Let me see.”

Ellie rolls her eyes but pulls her jacket away to uncover the wound. It’s not very long and doesn’t look very deep, but there’s a lot of blood. “Oh my god, you need stitches! Go to the freakin’ hospital and stop trying to be a hero, Bishop.”

Ellie gives him a look. “I’m not ‘trying to be a hero’, okay? It’s just a scratch.” She presses her jacket to her arm again.

“‘Just a scratch’ wouldn’t bleed like that.”

“How would you know? You’re not a doctor.” She gets to her feet angrily, intending to march away from him and his overprotective nonsense, but she sways slightly once standing and realizes that moving right now isn’t a great plan. 

“I might not be a doctor, but I’m not an idiot.” It’s only then that Nick notices how pale she is, and he grabs her uninjured arm urgently to keep her upright. “Seriously,” he insists, his voice hard. “I’m not joking. You need to be looked at.”

“No, I don’t! I’m fine!”

Nick shakes his head at her, not understanding why she’s being so stubborn. “You’re obviously not! What are you, afraid of needles or something? Come on, I’ll hold your hand and you can look away. Stitches aren’t that bad.”

“I’m not afraid of stitches,” Ellie snaps, “I just know what a doctor’s going to say if I show up to the ER, that’s all!”

“Oh, yeah? And what’s that?”

She wrenches her arm out of his grasp. “They’re going to say that I shouldn’t be working in the field where I can get hurt because I bleed too easily right now. They’re going to want to bench me, Nick! I can’t do that, alright? Are you happy now!?”

Nick catches onto the most important part of her little rant. “Why do you bleed too easily right now?” he asks her softly.

Her answer rips the breath from his lungs.

“Because I have leukemia.”

Her defiant expression fades as she watches him process the bomb she just dropped, and after a moment of silence, she sighs. “Don’t freak out, okay?”

“Don’t freak—don’t freak out—what!? How could I not freak out?” Nick feels wild, maybe slightly unhinged, and he has the almost undeniable urge to kick something. 

“Nick! Nick, look at me.” She places her hands on his shoulders and faces him squarely. “It’s not as bad as it sounds. I swear.”

“Leukemia means cancer, Ellie!”

“I know. But mine is at an early stage and it’s a kind that’s treatable, okay? The prognosis is pretty good.”

“Pretty good!? Pretty good’s not good enough. Not when—” He shuts his mouth into a hard line and looks away. Not when it’s you. Not when they’re talking about someone he can’t stand to lose.

“Not when what?” Ellie prompts.

Nick shakes his head and refuses to answer.

She winces a little, imagining what’s going through his mind. “I know I should have told you a long time ago. It’s just… I don’t want word getting around. If Gibbs didn’t bench me, Vance would.”

“You really think I would tell anyone if you didn’t want me to?” 

“No, of course not, but… you know secrets are hard to keep at NCIS. It wasn’t personal.”

“So you’ve just been… going through this alone?” 

There’s a heartbreak in his voice that Ellie doesn’t know how to deal with. She was expecting anger or sympathy, not pain. “Not alone, no,” she hastens to assure him. “I mean, my family knows.”

“And all those days you’ve been missing, were those appointments?”

“I have to have chemo infusions every now and then, and scans. And meetings with an oncologist and a few other doctors.”

“Alone,” Nick repeats. “Your family is what, a thousand miles away? It doesn’t matter if they know. They can’t exactly be there for you.”

Ellie shrugs uncomfortably. “It is what it is. Look, I’m sorry for not telling you, okay?”

Nick sighs deeply, feeling like he’s aged ten years in the span of ten minutes, and pulls her into a gentle hug, careful to avoid jostling her injured arm. “That’s not what’s important here,” he murmurs, reveling in the sensation of having her in his arms; it seems right, no matter how frail she might be at the moment. 

He feels her smile against his shoulder and his heart stutters. She’s so precious to him that he can’t imagine her death without something catching in his throat. 

“I’ll be alright. I promise.”

“Of course you will,” he murmurs, and after a second of hesitation, he shuts down the part of him that’s terrified of being made vulnerable. “You have to be, and you will, because you have me. I won’t let anything happen to you.”

Despite knowing deep down that Nick is as powerless here as she is, Ellie can’t help but believe him. He clearly means it, and who is she to argue with a man ready to take on the universe and win?

“You’ll be just fine,” he whispers, and kisses the top of her head. 

Of course she will be.

[kemetic-dreams]

                           Benefits of black seed oil

What is black seed oil?

Black seed oil has antioxidant and anti-inflammatory properties.

Black seeds are also known as black caraway, black cumin, kalonji, and black onion seeds.

They come from Nigella sativa, a small plant with pale purple, blue, or white flowers that grows in Eastern Europe, Western Asia, and the Middle East.

People have used the tiny black seeds of the fruits of N. sativa as a natural remedy for thousands of years. The seeds can also flavor curries, pickles, and bread in a similar way to cumin or oregano.

Black seed oil contains thymoquinone, which is an antioxidant and anti-inflammatory compound that may also have tumor-reducing properties.

People can ingest black seed oil in the form of capsules or apply it topically to benefit the skin. It is also possible to add the oil to massage oils, shampoos, homemade skin-care products, and fragrances.

Benefits for weight loss

Research has shown that black seed supplementation can help lower people's body mass index (BMI). The study participants did not report any severe side effects from taking this supplement.

A systematic review published in the Journal of Diabetes & Metabolic Disorders in 2013 found that black seed oil could be effective in tackling obesity.

Benefits for the skin

Black seed oil may be beneficial for people with the following skin conditions:

Eczema: According to a small-scale 2013 study comparing the therapeutic benefits of N. sativa with those of prescription medications, black seed oil can reduce the severity of hand eczema.

Acne: Research suggests that the antimicrobial and anti-inflammatory effects of black seed oil can improve acne. In one study, 58 percent of participants rated their response to this treatment as good, while 35 percent felt their results were moderate.

Psoriasis: A 2012 study on mice suggests that the oil may also have antipsoriatic benefits.

Black seed oil may also hydrate hair, soften skin, and act as a moisturizer, although there is a lack of scientific evidence to confirm these benefits.

Benefits for health conditions

Black seed oil may also be beneficial for some health conditions, including the following:

Cancer

Recent studies have shown that the thymoquinone in black seed oil can influence programmed cell death, or apoptosis, in several types of cancer cell. These include brain cancer, leukemia, and breast cancer cells.

However, much of the research on the effects of black seed oil on cancer uses cells rather than live humans, so researchers do not yet know how effective the oil may be to treat people with cancer.

Liver and kidney function

According to a 2013 study on rats, black seed oil may reduce liver and kidney disease complications and improve the organ structures. Researchers do not know if these effects would also occur in humans

Diabetes

According to an article in the Journal of Endocrinology & Metabolism, black seed oil may have antidiabetic properties and improve blood sugar levels. Again, this study used animal models, so more research is necessary to confirm the effectiveness of the oil in humans.

Infertility

A placebo-controlled clinical trial on men with abnormal sperm and infertility has found that black seed oil can improve sperm movement and increase sperm count and semen volume.

[wifewidownowwhat]

I just published my book “Wife, Widow, Now What?” based on my young cancer wife, then widow and beyond experience in.   It’s written to help those going through the cancer world, supporters, caregivers etc- with a plethora of resources, along with my journey.  It’s the first if its kind.  I’d like to talk to someone about it so more people out there can get help.  

It’s my version of Eat, Pray, Love and I wanted to offer it as a resource. I sure wish I had something like this when I was in the thick of it.

Thanks!

Rachel Engstrom

https://www.amazon.com/Wife-Widow-Now-What-Navigated/dp/B08KBV5DBL/ref=nodl_#immersive-

https://m.facebook.com/wife.widow.now.what/

More info:

Please check out my book! I wrote this in honor of my late husband, to help others who have walked, are walking and may walk one day ~in my shoes.

“Some days I think that if I didn't have "Grayson" tattooed on my wrist, I'd never believe that it happened. When I think back on the girl who went through everything in this book...I cannot believe she faced and tackled so many fires and wars and still came out on the other side."

When Rachel was 28 years old, her husband was diagnosed with leukemia. What they thought was the flu after working too many hours, turned out to be the life altering illness that would forever change everything they knew. Rachel became a cancer wife, manager, team cheerleader and expert juggler at life, while supporting her husband throughout his illness, until he died two days after she turned 31. She had to reboot her life and learn how to start over as a widow, without a map or guidebook to lead her. Rachel's humor, moxie and faith helped get her through the cancer world, and survive the calamity of errors that kept-on coming after he died. She fought tooth and nail to survive and is thankful for everything that brought her to present day, despite how hard it was to get there. She wishes she had had this advice and a story to reference when she was in the jungles of her cancer life and widowhood. Her hope is to provide you with some laughter, comfort, solace and guidance on your own journey, whether it be through the world of cancer, or any other life challenges.

Wife, Widow, Now What? chronicles Rachel’s journey using her narrative along with original Facebook, CaringBridge and Instagram posts, while giving resources on how to navigate cancer diagnosis, treatment, insurance, disability, finances, health care directives, emotions, patient and caregiver self-care and support, and much more.

This is the first of its kind to be written in this hybrid style of a memoir and self-help by a cancer spouse/significant other for other spouses/significant others or those navigating the cancer process.

In addition Rachel includes all the music she listened to during her journey, if you'd like to make a playlist for your reading pleasure.

[wisdomrays]

TAFAKKUR: Part 64

Playing with Genes: Gene Therapy : Part 2

Candidate diseases

During the last 4 decades, gene therapy for many diseases has progressed from preclinical to clinical studies; these range from monogenic recessive disorders such as hemophilia and cystic fibrosis to more complex diseases such as cancer, cardiovascular disorders, human immunodeficiency virus (HIV), neurological and ocular pathologies. The prevalence of diseases that fall under the scope of gene therapy is enormous and most of them have catastrophic or fatal outcomes. Therefore, gene therapy approach for almost any of the diseases mentioned above has an obvious appeal and rationale. To date, more than 1,540 gene therapy clinical trials have been initiated, and these are continuing or have been completed in 28 countries, using more than 100 genes, including antigens, cytokines, tumor suppressors, growth factors, and deficiency genes.

Candidate monogenic disorders that are considered to be good candidates for treatment by gene therapy include the hemoglobinopathies, X-linked genetic disorders, amino acid metabolism disorders, and lysosomal and other storage diseases. Currently, there are more than 4000 monogenic diseases registered in the OMIM database. The ultimate aim in treating monogenic diseases with gene therapy is the correction of the disorder by the stable transfer of the functioning gene into dividing cells (stem/progenitor cells), which will ensure the permanence of the correction. The first recognized successful clinical gene therapy trial involved the treatment of 11 children who suffered from SCID-X1 (Severe Combined Immunodeficiency), an X-linked inherited monogenic disorder caused due to a mutation in the common cytokine receptor gamma chain (γc). In these patients, immunity was not fully developed due to the blocking of T-cell and natural killer cell development as a result of mutation. Unfortunately, the trial in SCID-X1 also exemplified one of the potentially serious side effects of gene therapy. Three of the children developed uncontrolled clonal T-cell proliferation, that is, leukemia, almost 3 years after treatment. This case was associated with the integration of the retroviral vector close to the promoter of the LMO-2 proto-oncogene. As a result, LMO-2 protein expression was up-regulated in an abnormal way and resulted in leukemia. Another candidate monogenic disorder for gene therapy is cystic fibrosis (CF), in which abnormally thick mucus is produced in the lungs of the patients, causing difficulty in breathing and increasing the frequency of serious lung infections. CF is known as the most common inherited genetic disease in Europe and USA, especially within the Ashkenazi Jewish population. The average life expectancy of patients with CF is less than 40 years; hence the treatment of this disease has become one of the prime targets of gene therapy research.

In addition to its use in the treatment of monogenic diseases, gene therapy is also becoming a therapeutic alternative for the treatment of various forms of cancer. Indeed, almost 65% of ongoing clinical trials are related to cancer (more detailed information is available at www.wiley.co.uk/genmed/clinical), an area in which much more promise can be seen; this is also a reflection of the urgent need for new therapies to tackle the escalating incidence of this disease. Several different principles are used to treat cancer, including gene therapy that is targeted at tumor suppressor genes, such as p53, or central signaling molecules, as well as "suicide gene" therapy, in which the transgene is capable of converting pro-drugs (selectively less active drugs) into drugs that are toxic for tumor cells. Furthermore, various gene therapy protocols have been developed to strengthen the host’s anti-tumor immune responses by immunotherapy. Most of these studies have been early clinical trials designed primarily as studies of the safety, applicability, and toxicity of gene therapy. Several of these phase I and II studies have, however, shown partial remission of tumors and, in rare cases, complete remission. However, complete cure of the tumor has not yet been achieved. In some trials, including TP53 gene therapy trials, regression in tumor size has been observed in up to 50% of patients. China has become the first country to license gene therapy as a regular treatment for neck and head cancer; here Gendicine, a replication-defective Ad5 vector expressing p53 from a Rous sarcoma virus (RSV) promoter, is used for therapy.

In addition to its applications for cancer and monogenic diseases, gene therapy has become one of the favorite methods in cardiovascular research field. This is in step with the rise in clinical trials for cardiovascular gene therapy from 8.3% to 9.1% during the last few years, becoming the second most popular application for gene therapy. In accordance with the variety and occurrence of cardiovascular diseases, different gene therapy strategies have been developed to tackle each disease on its own terms. The expectation is that gene therapy will provide a new avenue for therapeutic applications in the growth of blood vessels, as well as the protection, regeneration, and repair of heart tissue, the prevention of the reoccurrence of constricted or narrowed arteries following cardiovascular intervention, the prevention of the rejection of a bypass, and risk-factor management. Long-term therapeutic gene expression is required in some diseases, such as hypertension research, where reversal and prevention are the key targets. On the other hand, for some other types of cardiovascular diseases, such as ischemia, atherosclerosis, and restenosis, shorter-term gene control will be sufficient to prevent further progress of the symptoms. Therefore, different gene-therapy vectors have to be considered for the treatment of each specific cardiovascular disorder.

Consequently, gene therapy offers new avenues of treatment for diseases including monogenic disorders, cancer, cardiovascular diseases, infectious pathologies and many more. As we follow the tradition, “God did not send down any illness for which He did not also send a cure (Bukhari)”, gene therapy using either viral, non-viral, or any other novel methods may pave the way for the cure of many diseases that are highly prevalent in the world and which for decades have been perceived as untreatable.

[sunnahealinguk]

Studies suggest that this oil may offer many health and cosmetic benefits, such as aiding weight loss, improving skin conditions, and even treating cancer and diabetes.

People have used the tiny black seeds of the fruits of N. sativa as a natural remedy for thousands of years.

Black seed oil contains thymoquinone, which is an antioxidant and anti-inflammatory compound that may also have tumor-reducing properties.

A systematic review published in the Journal of Diabetes & Metabolic Disorders in 2013 found that black seed oil could be effective in tackling obesity.

According to a 2013 study on rats, black seed oil may reduce liver and kidney disease complications and improve the organ structures. Researchers do not know if these effects would also occur in humans.

Research suggests that the antimicrobial and anti-inflammatory effects of black seed oil can improve acne. In one study, 58 percent of participants rated their response to this treatment as good, while 35 percent felt their results were moderate.

Recent studies have shown that the thymoquinone in black seed oil can influence programmed cell death, or apoptosis, in several types of cancer cell. These include brain cancer, leukemia, and breast cancer cells.

[safty]

so...what's your thoughts on the ending of raw?

I feel like they pulled the trigger on everything really quick because of the leukemia relapse, but obviously they’re making it work as best as they can for what’s happening. It’ll be interesting to hear Dean cut a promo next week about his reasoning because I feel like the way that they set it up, Dean was obviously emotional about the whole night and then got offended for Seth celebrating their victory or something? It’s weird, I need to watch it again. 

I can watch Dean and Seth fight all day and be entertained. I dunno. I don’t follow any wrestling blogs for their opinions and I don’t track tags so I don’t know what anyone else thinks and I think I’m happier for it. I’m wondering if someone will go to smackdown at the end of the day as well, and I’m really super wondering if Crown Jewel is just going to implode on itself and be canceled. 

Hoping Roman recovers fine and we get a really dramatic WWE 24 I can use to clear out my sinuses mostly. I think he’ll at least enjoy some time with his family. I know a lot of cancer survivors and while it’s not something to be scoffed at, a lot of people get it and at least from the angle of mentally tackling it, he’s been there before so he knows what to expect. Now it might be even easier because he has buckets of money to throw at it. 

(This has been my analysis)

[pramukhdentalcare]

Are you faced with bleeding gums? Find Cause and Treatments of Bleeding

If you are suffering from bleeding gum issues, it is essential to immediately address the problem. You need to book an online appointment with a top dentist at a reputable dental clinic. He would assess the issue and provide the required remedies without wasting any time.

What are the specific causes of bleeding gums?

There can be many factors that lead your gums to bleed. Arguably the commonest reason is Periodontitis. It is a type of advanced gum disease. When you neglect caring for your oral hygiene, you may suffer from it.

When you suffer from leukemia – blood cancer, there can be chances of bleeding gums. Moreover, it your body has a severe vitamin deficiency, your gums can bleed. You need to revamp your daily diet to tackle it. Gingivitis can cause gums to bleed, too. In some cases, when there is a lesser number of clotting cells, your gums can bleed.

Treatment 1 – Regular visits to dentists

The most effective way to treat the issues of bleeding gums is visiting a certified and reliable dentist at a clinic. He would assess the problems and treat the conditions. You must keep in mind to regularly visit a top-rated dentist. There should not be any laxity.

Treatment 2 – Maintaining oral hygiene standards

You should serious focus on improving and maintaining oral hygiene standards. There should not be any compromise. You must brush your teeth daily. Also, take at least a couple of minutes to thoroughly brush your teeth and clean your tongue.

Treatment 3 – Stop smoking

Another method you can apply is to not rely on a new technique but simply stop smoking. Smoking, especially chain smoking, can significantly aggravate the problem of bleeding gums. So, you need to stop it to counter the problem.

Treatment 4 – Include foods rich in vitamin C in your diet

You should consult a nutritionist and include a range of foods rich in vitamin C in your dialy diet. There are many varieties of fruits and vegetables that are loaded with vitamin C – oranges, carrots, red peppers, etc.

Treatment 5 – Cold compress on your gums

If you regularly apply cold compress on your gums, bleeding may stop. You would get relief from the treatment procedure.

Discuss the issue with a dentist

It is wise to discuss the issue of bleeding gums with a trusted dentist of a good dental clinic such as Pramukh Dental Care. He would guide you suitable to counter the problem.

[newyorkroleplay-archive]

RAUL VARGAS --

Birthdate: April 6th, 1982 ( 36 ) Gender and Pronouns: Male, he/him Hometown: New York, New York Neighborhood: Midtown, Manhattan Occupation: ER Doctor Faceclaim: Alfonso Herrera Trigger Warnings: Cancer, Death, War.

BIOGRAPHY --

For the first few years of Raul Vargas’s life, nothing happened. At least nothing out of the ordinary. He was the first-born child – a son at that – and as such, the trajectory of his life had more or less been decided for him before he had even been born. He was the heir, the future protector of the family name, and the shoulder upon which all of the responsibilities would lay. This was nothing new; Raul had been socialized to accept these things as his lot in life from the moment of his birth, as had his father before him, and any son that he should have in the future. This all came to a head, though, when his younger sister, Elena, was born. Raul was five years old and already everything his parents could ever have hoped for – he was serious and articulate, the spitting image of his father, and he carried himself with an arrogance that could only be born of knowing your place in the world. Elena, though, was the opposite. She was fragile and small for her age; it seemed like she was always in and out of the hospital. Just days before her first birthday, she was diagnosed with leukemia. As unfortunate as this was, the Vargas family was prepared to tackle this problem head on, as they would any other that came their way. They even thought that they were more aptly prepared than other families. After all, there was no expense that they would not pay to help their child, and no length they would not go to. It also helped that the Vargas name was well known in medical circles as the Vargas patriarch had sat on the board of one of the most outstanding hospitals in the New York metropolitan area for decades.

Despite all of their resources and their far reach, Elena Vargas did not live passed her second birthday. The trauma of it deeply affected young Raul and he withdrew into himself. A once bright spirit had been dulled under the guilt of having failed to save his sister. Noticing this change in their son, the Vargases instituted monthly family camping trips in the hopes that getting away from the responsibilities of their life, even for just a weekend, would help their family recover from the loss. It was on one of these camping trips that the Vargas family experienced an upheaval once again. A teenage Raul had just returned from a job around the campsite when Mariana and Silas stumbled in. They were disoriented and terrified. Little did the Vargas know that what was supposed to be a routine camping trip would lead to two adopted children. For the first few months after the adoption, Raul tried his best to maintain his distance from his new siblings. There was a part of him that was terrified of the idea of becoming too close to them; after all, he had loved and failed Elena at a young age and the idea of failing another sibling was too much for him to bear, but despite his best interests, his new siblings wheedled themselves into his heart. Mariana especially. She was feisty and protective, often attempting to take care of Raul despite their great age gap, and he loved her for it.

When Raul turned 18, there was little discussion about the course that his life would take. Naturally, it was assumed that he would go to college, major in business, and one day take over his father’s role on the hospital’s board. Raul, though, had different ideas for his future. Without his parents’ knowledge or their blessing, he enlisted in the United States Army. The country was embroiled in overseas wars and Raul believed that his skills would be better served actually helping people. He served two tours overseas in the role of combat medic, and when he returned, the world was different. Raul was different. He had lost some of the spark in his eyes and grown a much harder outer shell, but there was still a part of him that was as Vargas as before he had left. Arrogant as ever and determined to stave off the PTSD that plagued other servicemen, Raul applied to medical school. Now, at thirty-six, he has since completed medical school and is serving as an ER doctor in the same hospital on whose board his father sits.

PERSONALITY --

( + ) fair, loyal, protective. ( - ) abrasive, aloof, arrogant.