#synaptic plasticity

[thedaily-beer]

Mother Earth Synaptic Plasticity Hazy IPA (Picked up at Windmill Farms). A 3 of 4. Nice orange citrus and some faint herbal notes behind it, with some candy fruit notes, too. Quite juicy and light-bodied, with reasonably high carbonation. Solid.

[ghostoflostsplendor]

Yes I strongly suspect it's related to the extracellular matrix and cytoskeleton! Very important in connective tissues as well as in synapse formation. While working on my Bachelor's degree I actually came across a research paper linking a cytoskeleton protein to troubles with behavioral flexibility and autism risk genes. It's on fruit flies tho, so we will see if it translates to humans. That same protein activates an enzyme which breaks down collagen.

Alternatively/additionally, I wonder if it could be related to mast cells. MCAS is a common comorbidity with hypermobility, and mast cells are in our brains as well as in connective tissues. They could definitely explain the GI issues, those are common in allergies and MCAS after all.

comorbid disorders are either like "yeah ok, makes sense" or "what the fuck"

adhd and autism having a high comorbidity rate? yeah checks out

adhd and autism both having high rates of comorbidity with hypermobility and GI issues? thats an evil curse

[medicomunicare]

AP-1: a keymaster FOStering the JUNction among several tissues by wERKing on the MAPk

AP-1: ID and biological functions AP-1 (Activator Protein-1) is a transcription factor that plays a key role in regulating gene expression involved in a wide range of cellular processes, including proliferation, apoptosis, differentiation and stress response. AP-1 is a protein complex composed mainly of members of the Fos (c-Fos, FosB, Fra-1, Fra-2) and Jun (c-Jun, JunB, JunD) protein families,…

[aeontimaeuscrux]

Cognitive Pruning

Definition: Cognitive pruning is a cognitive phenomenon in which the human brain selectively eliminates or weakens less relevant or less frequently accessed memories and information to make room for the retention and consolidation of more important or frequently used knowledge and experiences. It is an adaptive process that helps optimize memory resources and prioritize information based on its significance and utility.

Cognitive Pruning aligns with the concept of “Epistemic Relevance” in epistemology, the branch of philosophy concerned with knowledge and belief. Epistemic relevance explores how individuals determine which information is relevant to their beliefs and understanding of the world. Cognitive pruning can be seen as a practical manifestation of this philosophical concept, as it reflects the brain’s innate ability to discern and prioritize information deemed relevant to one’s cognitive processes.

“In the labyrinthine meadows of memory, the mind becomes an efficient gardener, trimming away the overgrown vines of trivial recollections to nurture the blooming roses of knowledge. Cognitive pruning, the brain’s art of forgetting, is the sculptor of our mental landscape, ensuring that the most meaningful and useful memories take root and flourish.”

-Me. Today. Just Now

[arsonfae]

letting highschoolers take college math classes is great bcs they can learn the material and pass the classes, they just use to make jokes like “the nearest positive co-terminal angle of pi/3 😏”, “the crest of 34.5+34.5sin(.1x)😏😏😏😏😏😏”

[seongwars]

away with the wind | twilight

Pairing: dragonrider!Seonghwa x ex-dragonrider!Reader AU: dragon rider au | strangers -> lovers Summary: a spinal injury forces you to retire from dragon racing, and with it, the end of your engagement to Song Mingi. Park Seonghwa, a rising star in the world of dragon racing and heir to the prestigious House Park, seeks a new dragon after an unfortunate accident on the skyway. As the saying goes, “The enemy of my enemy is my friend.” Word Count: 6.8K (sorry I got carried away) Warnings: not proofread, seonghwa doing wrongs, angst

a/n: first version of chapter ix! i was also watching derry girls while writing this so listen to 'independent love song' by scarlet if you wanna get the feel for the last scene of this chapter

Fic Masterlist

The grand chamber was dimly lit, the only sources of light being the flickering holographic displays and the soft glow of the council members’ robes. The air was thick with anticipation as the council awaited the presentation.

“Ready whenever you are, Dr. Kang,” Lord Hong announced, his voice resonating through the chamber.

Yeosang, standing beside the holographic projector, bowed respectfully. He took a moment to adjust the hologram, ensuring every detail of Ajax’s anatomy was perfectly visible. The room fell silent as the intricate projection came to life, displaying the necropsy report for Subject 4201.

“Necropsy report for Subject 4201. Subject is a male, approximately 11 years old, measuring 20 feet in height with a wingspan of 40 feet. Initial examination reveals extensive claw marks along the dorsal scales, likely from recent combat.”

Yeosang zoomed in on the damage inflicted by Starshine during the Inferno Cup. Lady Lee brought her hand to her mouth in feigned horror, prompting Yeosang to roll his eyes at her theatrics. He then brought up the next holographic display.

Swiping over to the dragon’s head, Yeosang brought forward the manifestation of Ajax’s brain, enhancing the size of the organ for the Council’s scrutiny. 

“The brain shows signs of abnormal growth in the amygdala, the region associated with aggression and fear responses. This hypertrophy suggests heightened aggression and unstable behavior. Further examination of the neural pathways reveals signs of synaptic plasticity, which may indicate a history of adaptive responses to high-stress environments. This could result in unpredictable and erratic behavior patterns.”

“Is this a common trait in Longhorns, Dr. Kang?” Lord Kim interjected.

Yeosang maintained his composed demeanor, though he felt slightly irritated at Lord Kim’s prodding. Taking a moment to gather his thoughts, he ensured his tone remained respectful yet authoritative. 

“While hypertrophy in the amygdala is not uncommon in Longhorns, the extent of the growth observed here is unusual,” he explained, his voice steady. “Further studies are necessary to determine if this is an isolated case or indicative of a broader trend within the species.”

Lord Kim nodded, the soft rustle of his robes barely audible as he leaned back in his chair. Yeosang then moved on to the next hologram, which flickered to life, casting a light that manifested into Ajax above their heads.

“In summary, subject 4201 exhibits significant physiological power and complexity,” Yeosang began, his voice steady and clear. The hologram displayed intricate details of the dragon’s anatomy, each scale and muscle rendered with precision. “I’ve concluded that the observed unpredictable behavior indicates potential neurological instability. End of report.”

Chairman Jang’s eyes narrowed as he leaned forward, the light catching the sharp angles of his face. “And the report of parentage?” he asked.

Yeosang adjusted the hologram, bringing up a new set of data. “The DNA test results showed no significant anomalies, your grace. The dragon’s genetic makeup is consistent with what we have documented in our archives. There are no indications of any unusual lineage or mutations.”

Lord Kim studied him for a moment, his gaze penetrating. “Are you certain, Dr. Kang? This information is crucial to understanding where this Longhorn may have originated from.”

Yeosang nodded, maintaining his calm facade. “Yes, your grace. I am certain. The DNA results confirm that this dragon is of standard lineage.”

“Lord Kim, we have all the information we need. Continuing this investigation is a waste of our resources and time,” Lady Lee snapped, her voice sharp and echoing slightly in the grand council room.

“We need to be thorough,” Lord Kim insisted, his tone unwavering. The flickering light from the hologram cast shadows across his stern face, highlighting the furrow in his brow.

“The dragon’s physiology and neurological state are well-documented. We have other priorities that demand our attention,” she countered, her words heavy with urgency.

Lord Hong nodded in agreement, the soft rustle of his robes breaking the silence. “Lady Lee is right. We are diverting valuable time and effort. This report should be concluded.” His voice was measured, a stark contrast to the rising tension between his colleagues.

“If Dr. Kang has reported no abnormalities in his findings, then we must move on to the next agenda item,” Chairman Jang interjected with finality. “Thank you for your time, Dr. Kang.”

The room fell silent, the air thick with unresolved conflict. Yeosang remained silent, grateful that the focus had shifted away from his lie, but acutely aware of the brewing storm between the Council members.

“Would it be possible for the copies of the report to be made available, Dr. Kang?” Lord Kim interjected, his eyes boring into Yeosang, challenging him to reveal the truth.

Yeosang hesitated, his fingers trembling slightly as he adjusted his glasses. “The report is rather unremarkable, your grace,” he replied coldly, staring straight at the elder.

Lord Hong’s eyes narrowed. “Is there a problem, Dr. Kang? The Council has a right to see the report.”

Yeosang tightened his jaw, feeling the tension ripple through his muscles as the Council’s insistence caught him off guard. His irritation simmered just beneath the surface, barely contained.

“Of course, I will ensure the report is made available,” he said smoothly, his voice dripping with false sincerity, masking the venom beneath. “I just need a little more time to… finalize some details.”

“Finalize what details? Are you implying that this report today was not conclusive?” Lord Kim’s voice was cold and unyielding, each word a deliberate challenge.

Yeosang’s eyes flashed with annoyance, but he quickly masked it with a calm facade. “I assure you, Lord Kim, the report is thorough. However, there are always minor adjustments to be made for clarity.”

Kim Sangjoong’s gaze hardened, his suspicion evident. “Minor adjustments? Or are you buying time to cover up discrepancies, Dr. Kang?”

“That’s enough,” Chairman Jang’s voice concluded, the tone unmistakable, leaving no room for argument. “Dr. Kang, you have until the end of the day to produce copies of the report to the Council.”

Yeosang felt a surge of anger but forced a smile. “I understand your concern, Lord Kim. Rest assured, the report will be delivered by the end of the day, as requested.” His tone was polite, but the underlying threat was present.

The room remained tense, the air thick with unspoken conflict. Yeosang knew he had to tread carefully, but he relished the challenge.

Seonghwa strode through the hallways of the Park estate, his footsteps echoing off the marble floors as he awaited the results of Ajax’s necropsy from Kim Sangjoong. The grandeur of the estate, with its high ceilings and ornate decorations, did little to calm his racing thoughts.

“Ms. Jang,” he called out, his voice calm yet authoritative. His mother’s assistant looked up from her desk, immediately recognizing him. She adjusted her glasses and gave him a polite nod.

“Yes, your grace?” she asked, her tone respectful but familiar.

“I need a list of all the attendees from the Inferno Gala,” he requested, his eyes scanning the room. “Sponsors, stakeholders, riders—everything.”

Ms. Jang nodded and quickly began typing on her laptop. The soft clacking of keys filled the room as Seonghwa paced back and forth, his mind a whirlwind of thoughts. He glanced at the clock on the wall, each tick amplifying his impatience.

After a few moments, Ms. Jang handed him a sleek tablet. “Here it is, your grace,” she said. “The complete list.”

Seonghwa took the tablet and offered her a small smile in thanks. As he walked back to his quarters, he scanned the names, noting familiar faces and new ones, the organizations they represented, and the teams they raced for. Each name brought back memories of conversations, deals, and promises made. He needed to ensure that every attendee was accounted for and that no detail was overlooked.

“Treasure Holdings, Blue Bird Airways, Answer Tech,” Seonghwa muttered to himself, activating the hologram interface. These were big name sponsors in dragon racing and nothing seemed out of the ordinary. 

He swiped to the next category of Aurora’s political elite, scanning the list with a practiced eye. Names like Lady Baek and Lord Yoon stood out, both well-known figures in the political landscape. As he continued down the list, he reached members of the Council and their guests. Lord Hong Bum Soo and Lady Hong Sara, Chairman Jang Ki Young, Lord Kim Sangjoong and Lady Kim Miyeon–

She was never one to miss an event, especially one of this magnitude. He quickly re-scanned the rest of the list, hoping it was a mistake, but her name was nowhere to be found. Had she been deliberately excluded?

Lady Lee’s absence was not just unusual—it was a glaring anomaly. Taking out his phone, he dialed Kim Sangjoong, hoping for news of the necropsy report. The phone rang a few times before Lord Kim answered. “Seonghwa, what’s the matter?”

“I have news for you, should you have any to share with me,” Seonghwa said, his tone measured.

The elder chuckled softly, shaking his head. “I regret to inform you that the report returned without any anomalies. It was conclusive, indicating that the dragon is of standard lineage.”

“That can’t be,” Seonghwa said, his voice laced with disbelief. “Y/N showed me Ajax’s anatomy in video footage a few months ago. She noted that his angulation was much more moderate than a Longhorn’s, and his wings were longer. He also exhibited an unusual level of speed and agility.”

The elder’s eyes widened slightly. “That does sound…unnatural for the breed…” He paused, his gaze drifting out the large, arched window of his office. He noticed Lady Lee in conversation with a young lab assistant, her animated gestures contrasting with the assistant’s calm demeanor.

“Your grace?” Seonghwa’s voice brought him back to the present.

“Yes, apologies. Please continue.”

“I wanted to let you know that I pulled the guest list from the gala and noticed that Lady Lee was missing.”

The elder’s brow furrowed in concern. “That’s certainly odd. She never turns down an opportunity for an event given her rather…vainglorious nature. Her absence is highly unusual.” Lord Kim glanced at the ornate clock on the wall, noting the late hour. If he were to leave now, it would be an opportunity to learn more about Lady Lee’s next moves.

“It seems Lady Lee is just about to leave for the day,” Lord Kim informed the younger. “Thank you for the information, Seonghwa.” He quickly pocketed his phone and hurried towards the exit, his mind racing with possibilities. The corridors of the capitol building were beginning to empty as the day drew to a close, and he needed to act fast.

The soft murmur of conversations and the shuffle of footsteps filled the air, creating a symphony of end-of-day activity. The tension in the air was palpable, each step Lord Kim took echoing his urgency.

“Ah, Lady Lee! Will you be attending General Choi’s birthday celebration?” he called out, his voice cutting through the ambient noise, and scaring the lab assistant. The young man, not much older than 20, bowed before taking his leave. 

Lady Lee paled, her confident demeanor faltering for a moment. “O-Oh? Is that this weekend?” she stammered, her eyes darting around as if searching for an escape. She forced a smile, though it didn’t reach her eyes.

“I must have overlooked it. I’ve been quite busy with…personal matters,” Lady Lee said, her voice wavering slightly.

“Personal matters?” Lord Kim pressed, his curiosity piqued. “Well, I hope everything is alright.”

She hesitated, her fingers fidgeting with the hem of her sleeve. “Yes, well, it’s nothing that concerns the council.”

Lord Kim nodded slowly, not entirely convinced. “I see. Well, I do hope you’ll make it to the celebration. Miyeon and I look forward to seeing you.”

“Thank you, Lord Kim. I appreciate your concern,” she replied, her voice steadying. 

As Lady Lee turned to leave, Lord Kim watched her closely. There was something off about her behavior, something that didn’t sit right with him. Her usually confident demeanor seemed strained, and her eyes darted around nervously. His mind raced with questions, each one more urgent than the last. What was she hiding? And why did it feel like time was running out?

[NEW MESSAGE]

[Lord Cash Money]: Results are in 

[Lord Cash Money]: Nothing out of standard

You let out a huff as you read Seonghwa’s message and sent back a quick ‘Thanks’. Dismounting Cirrus, you felt the cool leather of the saddle beneath your hands, but an uneasy feeling settled in your chest. You knew Ajax was definitely not half Fury, but something else entirely. The thought sent a chill down your spine at the implications of what his other half might be.

The late afternoon sun cast long shadows across the manor as you helped Sohee down from the saddle. You slung her backpack over your shoulder, the weight a familiar comfort, and dialed the only person you knew you could vent to besides your grandmother and sister.

“I hate the government,” you said, balancing your phone between your shoulder and ear while you toed off your shoes and hung up your niece’s backpack. The scent of oil pastels and dragon scales lingered in the air.

“Who doesn’t?” Jongho’s voice came through the line, gruff yet playful. You could almost picture his mischievous grin. What’s going on?” he asked, his tone shifting to one of curiosity and concern.

Choi Jongho was the oldest son of the Dune Choi Family and cousin to the Auroran Choi Family. Although they were considered one of Dune’s noble houses, your families had been breeding partners for as long as your grandmother could remember.

Jongho had always been like a little brother to you, his presence a constant in your life—a mix of annoyance and comfort that only a true sibling could provide. His sharp wit and the shared history between your families created a connection that was unbreakable, no matter how much he might drive you crazy at times.

“The test results came back conclusive. There’s nothing out of the ordinary with Ajax’s lineage.”

“Bullshit,” Jongho snapped, pacing his room. “I watched the footage you sent me, read through the pedigree, and everything seemed off. Someone’s tampering with the results.”

You nodded, frustration evident. “Exactly. I’m thinking there has to be something more nefarious in his lineage. Ajax has always been promoted as a hybrid between a Fury and a Longhorn, but I don’t think a Fury fits the bill. It has to be a breed that’s aerodynamic.”

Jongho furrowed his brow. “Aerodynamic, huh? That narrows it down a bit. Maybe something with a sleeker build? A Wyrm variant? Or a Razorback?”

You snickered. “Hongjoong is going to have your head if he hears that. But even those breeds don’t seem quite right. There has to be one that’s also intelligent. Ajax was somehow able to learn Cirrus’ maneuvers, and I know for a fact Mingi couldn’t have taught him that flip.”

Jongho sighed, massaging his brow. “I’ve always told you I didn’t like him nor his ugly dragon. I plan to set up shop in my uncle’s library and we can dig deeper when I’m in town. You’re coming to his celebration, right?”

You groaned, pulling your pillow to your chest. “Do I have a choice?”

“If you don’t, I’ll tell everyone you think San is handsome.”

Rolling your eyes, you retorted, “San is handsome. That doesn’t work on me anymore.”

Jongho smirked, a mischievous glint in his eye. “Fine, then I’ll tell everyone about the time you fell into the fountain trying to impress him.”

You gasped, sitting up abruptly. “Choi Jongho, you wouldn’t dare!”

The grand hall of the Choi Estate was a sight to behold, a testament to the family’s wealth and status. The walls were adorned with intricate tapestries depicting the family’s storied history, their vibrant colors and detailed embroidery telling tales of valor and honor. The atmosphere was one of celebration and reverence, as friends and family gathered to honor the Choi patriarch on his special day.

San’s father, the elder General Choi, greeted guests up and down the hall, offering glass after glass of champagne and other spirits. His laughter boomed through the room, a testament to his larger-than-life personality. You managed to dodge him, offering your grandmother as a sacrificial lamb as you slipped away, her knowing smile indicating she was more than willing to take one for the team.

You weaved through the crowd, feeling a bit out of place in your simple but elegant strapless black gown. Its understated design contrasted with the more extravagant attire around you, yet the gown’s classic cut and the way it hugged your figure made you feel confident and poised.

“Are you here for a funeral or a celebration?” a familiar voice quipped behind you.

You whipped around to find San, the young General Choi, clad in a perfectly tailored suit that accentuated his broad shoulders and commanding presence. The corners of his mouth twitched into a smirk as he took in your startled reaction.

“Very funny,” you replied, rolling your eyes but unable to suppress a smile. “I was just trying to avoid your father’s relentless hospitality.”

San chuckled, his laughter a deep, comforting sound. “He does have a way of overwhelming people with his enthusiasm,” he admitted, glancing over at his father, who was now engaged in a hearty conversation with a group of military officials. “Looking for someone?”

“Just a familiar face,” you murmured, your gaze drifting away from the General. You scanned the crowd, your heart pounding as you searched for a certain someone. Striking, charming, refined, and utterly infuriating, with an undeniable pull—a magnetic attraction you couldn’t ignore.

“Am I not a familiar face?” San cocked his head, giving you one of his infamous cat-like smiles.

“Yes, but you’re not the one I’m looking for,” you scoffed, hitting his arm playfully. 

San brought his hand to his chest, feigning a dramatic gasp. “And here I thought I was unforgettable.”

“You are, just not in the way you think.”

“Ah, so there is someone! Now I’m intrigued.”

Unbeknownst to you, a pair of dark eyes watched from a distance. Seonghwa’s jaw tightened at the sight of you engaging with San, his usually composed demeanor slightly ruffled. A flicker of annoyance crossed his features as he struggled to maintain his cool amidst the growing irritation.

Trying to maintain his composure, he excused himself and stepped out into the cool night air. The distant noise of the party faded behind him as he took a deep breath, struggling to make sense of his conflicting emotions. How could he be so torn over someone who didn't even know how he felt?

“Seonghwa?” a familiar voice called out, breaking his moment of solitude. He turned to see Yeri, a former fling, standing a few feet away. She offered a tentative smile, as her eyes widened in calculated interest. 

“Yeri,” he acknowledged, his voice neutral but with a hint of underlying tension. 

There was a brief, awkward silence before Yeri spoke again, her tone measured and deliberately soft. “It’s been a while, hasn’t it?”

What had started as a casual, no-strings-attached situation between Seonghwa and Yeri had quickly turned into a short-lived romance riddled with miscommunication and trust issues. Seonghwa's demanding training schedule left Yeri feeling neglected and alone, while her need to maintain control on the crumbling relationship only added to the tension.

“Yeah, it has,” he agreed, his gaze drifting to the city lights beyond the terrace in an attempt to avoid the emotional weight of the conversation. 

“How’ve you been?” she asked, her tone smooth, almost tender though her eyes remained sharp.

“Fine,” he replied, his irritation from earlier slowly ebbing away, replaced by a different kind of tension.

She studied him for a moment, her expression thoughtful and probing. “You seemed a bit tense back there. Everything okay?”

Seonghwa sighed, leaning against the stone rail as his eyes wandered towards the grand hall, your figure only a few feet away from him. “Just… a lot on my mind, I guess.”

“Want to talk about it?” Yeri’s voice broke through his reverie, carrying a nostalgic note. 

He hesitated, then shook his head. “It’s not important.”

Yeri took a step closer, her gaze growing more intense as she searched his face for cracks in his resolve. “We used to share everything, remember? What happened to that?”

Despite their history, Yeri couldn't help but reach out to Seonghwa, feeding on his vulnerability to keep him tethered to her. "I know things ended badly, but we've both changed. Maybe we could give it another shot?"

Seonghwa’s emotions were a tangled mess as he looked into her pleading eyes. “You know that things weren’t good between us.”

Yeri took a step closer, her fingers lightly tracing the outline of his jaw. Her touch was gentle, almost tender, as she searched his eyes for any sign of resistance. “Why does being together have to be the only option?" she whispered. She leaned in, her breath warm against his skin, and her lips brushed against his.

Seonghwa knew it was wrong, but he just needed an escape, allowing himself to be drawn back into her orbit. The kiss lingered on his lips like a bittersweet memory as he pulled away, his eyes clouded with regret. “We can’t do this here,” he whispered, his voice barely audible.

She nodded, understanding the need for discreteness. They walked in silence, the tension between them almost tangible as Seonghwa led them away from prying eyes. He couldn’t shake the feeling that he was losing himself in the process, compromising his values for a fleeting moment of solace.

“There you two are,” Jongho interrupted, sidling up to you and San with a glass of whiskey in hand. His eyes sparkled with mischief as he took a sip.

“Finally decided to grace us with your presence,” you teased, unable to hide the smile that spread across your face. Then, your brow furrowed in concern. “Wait, aren’t you too young to be drinking alcohol?”

In a rebellious gesture, Jongho lifted the glass again and finished off the remaining whiskey before sticking his tongue out at you playfully. “Age is just a number,” he retorted, letting out a satisfied sigh. 

“I’m using this as an opportunity to network and improve diplomatic relations between Dune and Aurora,” he added with a mischievous grin, gesturing around the opulent room filled with dignitaries engaged in animated conversations.

San rolled his eyes at his younger cousin's antics. “I wouldn’t exactly call selling dragons a networking opportunity,” he remarked dryly.

“I’m just trying to keep the family business afloat,” the younger Choi chuckled, unaffected by his cousin's skepticism. 

Before you or San could respond, the room fell silent as Song Tae Gyu entered, his face unreadable. The grand hall, once filled with lively chatter and laughter, now buzzed with hushed whispers. Snippets of conversation about “Mingi,” “the Council,” and “unstable dragon” floated through the air like a dark cloud.

“Song Tae Gyu has some nerve showing up after what his son pulled,” Jongho sneered, his gaze fixed on Mingi’s father with a stone-cold expression. Ever the purist, Jongho’s disdain was palpable. You could almost feel the weight of his contempt for the way the Songs had let their son disgrace their house and the sanctity of dragon racing.

“He’s simply carrying out his duties to my father,” San reminded his cousin, his voice composed despite the discomfort evident in his body language. He glanced around the room, noting the wary eyes and cautious glances directed at Song Tae Gyu. “I know the Songs feel terrible about the incident, but as a vassal House, they have their obligations.”

San’s words were measured, but you could sense the underlying tension. The incident with Mingi had cast a momentary shadow over the evening, and the presence of Song Tae Gyu only served to deepen the unease. 

“Ah, Tae Gyu! So glad you could make it!” the elder General Choi exclaimed, clapping a hand on the man’s shoulder. “I was just telling everyone about the time you and I got lost in the ravine and had to spend the night in a cave. Remember that?”

The room erupted in laughter as Lord Choi recounted the tale with exaggerated gestures, painting a vivid picture of their misadventure. Even Song Tae Gyu managed a small, grateful smile, the worry lines on his face softening.

Jongho rolled his eyes but couldn’t suppress the small grin tugging at his lips. He took a sip from his glass, the warm liquid sliding down his throat as he mulled over his father's words. "Your father always knows how to lighten the mood," he muttered to San before turning to face you, swirling his empty glass in a playful gesture to signal his exit from the conversation.

“I’ll be around tomorrow if you want to dig through the records. I’m sure we’ll find something on that wannabe Longhorn.”

“What did you say?”

“Nothing, just bullshitting.”

“No! About the wannabe part.”

Jongho stared at you incredulously. "He's a poor example of the breed, just like how his rider is a poor excuse--"

The mention of the word "wannabe" caught your attention like a firework exploding in your mind. You could feel your heart racing as you frantically searched your knowledge for any clues about this breed.

Wannabe… Imitation… Copy… The word echoed in your mind, reverberating with increasing intensity. Your breath caught in your throat, and your heart began to race as you frantically sifted through your mental catalog of dragon breeds and their levels of intelligence.

Dreamwood Ridgeback, biddable with high emotional intellect… Cascade Wyvern, alert and confident… Star Fury, fiercely intelligent but too rare… Nettled…

A sudden realization hit you like a bolt of lightning. You turned sharply to face San, your eyes widening with urgency and determination. "Do you have a copy of a breed encyclopedia?" You could almost feel the gears turning in your head, piecing together the clues and making connections. It was all starting to make sense now.

San looked momentarily puzzled, his brow furrowing as he tried to process your sudden question. Before he could respond, Jongho stepped in with a confident grin. “Of course they do, I left one here to read during summers,” he said, patting San’s shoulder in a playful yet slightly condescending manner, acknowledging his older cousin’s limited mental acuity.

“Longhorns aren’t meant to be particularly intelligent,” you began, your voice steady but urgent. “But if Ajax was able to learn Cirrus’ maneuvers, there could only be one breed that matches the description.”

The three of you exchanged tense looks, the weight of the mystery pressing down on you. Without another word, you all turned and rushed out of the hall, each step bringing you closer to uncovering the truth.

You were met with the scent of aged paper and polished wood as San pushed open the library doors. You couldn't help but pause to take in the vast collection, your fingers tracing lightly over the spines of leather-bound books before delving deeper into the labyrinth of shelves. Lost in your admiration, you turned a corner and suddenly froze.

There, in a secluded nook, you found Seonghwa tangled up in the arms of a woman. The intimate scene was a stark contrast to the peaceful setting of the library. Your breath caught in your throat, and your heart pounded in your chest.

“Oh shit!” you gasped, the words slipping out before you could stop them. Your hands flew to cover your mouth as Seonghwa and Yeri sprang apart, their faces flushed with embarrassment. Seonghwa’s eyes darted toward yours, panic evident in his expression. 

San, ever the protector, rushed to your side and positioned himself between you and the unexpected sight. For a moment, no one moved. The silence was deafening, broken only by Jongho’s approaching footsteps. 

“Gods, I’m so s-sorry, I didn’t mean to interrupt!” you stammered, your voice attempting to sound casual despite the hurt and confusion swirling within you. Why am I feeling this way, you wondered, the question demanding an answer that you can't give. 

You had always kept your relationship with Seonghwa strictly professional, despite the occasional flutter of emotions. Yet, seeing him with someone else stirred something unexpected within you. Was it jealousy? Or something deeper that you hadn’t acknowledged before? The thought unsettled you, adding another layer to the already tangled web of emotions you felt towards him. 

“I-I can explain–,” Seonghwa fumbled as he buttoned his shirt, the movements clumsy and rushed. He haphazardly threw his jacket back on, the fabric wrinkling under his frantic efforts. Yeri, equally flustered, tried to smooth her disheveled hair, her cheeks burning with shame. 

“We were just catching up. It’s been a long time since we last saw each other.” Her voice was shaky, betraying her own discomfort. 

“Well,” San began, addressing Seonghwa and Yeri. “If I had known the library would be used like this, I would have extended some charity to our esteemed guests.” His tone was polite but edged with a steely resolve that left no room for argument. “I’m sure we have a room befitting his grace as it appears that he is in desperate need of a hiding place—like a rat scurrying back into its hole.”

Yeri's face erupts in a fiery flush of humiliation as she hangs her head in shame, unable to bear the insulting words from San. San raises an eyebrow, daring either of them to stand up to him. "I'm leaving," she mumbles, quietly excusing herself without saying another word. As she walked away, the oppressive tension lingered in the air.

“R-Right. Well, I need to borrow the breed encyclopedia, so if I could just…” You fidgeted awkwardly, your finger darting around as you tried to locate the book. Jongho, noticing your discomfort, pointed to the upper shelf behind the former lovers. 

“It’s right there,” he said, his voice cutting through the thick silence as Seonghwa stepped aside to let you through. His eyes, filled with guilt, followed your every move.

"You good?" San asked, his protective instincts kicking in.

“I’ve got it, I just have to climb up,” you replied, your tone firmer than you felt. 

You began taking off your heels, the action giving you a moment to collect yourself. The cool marble against your bare feet contrasted the heat of your emotions. Lifting the skirt of your gown, you prepared to climb the ladder to the upper shelves when you felt Seonghwa’s hand on your arm. The unexpected touch sent a shock through you, and his grip was gentle yet firm, silently pleading for attention.

"I'll do it," he insisted, speaking in a low and earnest voice. You paused, looking up at him, meeting his eyes. In that moment, the vulnerability in his gaze disarmed you, but the hurt and confusion still swirled within your mind. 

"Please.”

Reluctantly, you stepped aside, allowing him to retrieve the book. Each movement he made was careful and deliberate, as if he were trying to prove his worth through this small act. You watched him reach the upper shelf and retrieve the encyclopedia, its weight seemingly insignificant in his hands. 

San’s eyes darted between you and Seonghwa. He couldn’t make sense of why Seonghwa was so insistent on helping you, a rare display of protectiveness that went against his aloof nature. A knowing smirk tugged at the corner of his lips.

Seonghwa handed you the book, his hand lingering for a moment longer than necessary, as if he wanted to say something more. His eyes held a silent plea, a desperate hope for a chance to explain himself, but your focus remained elsewhere, avoiding the intensity of his gaze.

“Thank you,” you murmured, clutching the book to your chest, its worn cover a small comfort as you put distance between yourself and Seonghwa. "I should get going," you suggested with exasperation evident in your voice. 

The intensity of the situation was suffocating, and you needed an escape. Without waiting for a response, you turned on your heel and walked away, each step feeling like a small victory against the turmoil that threatened to consume you. 

A wave of guilt washed over Seonghwa knowing that he was partially responsible for your sudden departure. His chest tightened and he clenched his fists, feeling the sting of his own actions. He stood there, paralyzed by the weight of his guilt, until San’s voice cut through the fog of his thoughts.

“I must say, your ability to find yourself in compromising situations never fails to impress me. It truly is a talent,” he remarked with mock admiration.

Seonghwa’s eyes flashed with anger as he spat out through gritted teeth, “And you seem to take great pleasure in reveling in another’s misfortune.” His voice was thick with venom, each word a dagger aimed at San.

“Isn’t that exactly what you were doing to Y/N?" San replied, his tone casual and unbothered, as if Seonghwa’s seething rage was nothing more than a mild inconvenience. 

Seonghwa opened his mouth to retort, but his words caught in his throat as his gaze fell to the ground. There, lying abandoned on the floor, were the heels you had left behind. The sight of them hit him like a punch to the gut–a reminder of your abrupt departure. His anger gave way as he walked over to pick up the shoes.

“I didn’t know,” he muttered, more to himself than to anyone else. “I didn’t mean to hurt her.”

“Well, she’ll be hurt more if she steps on a sharp object without any shoes on,” Jongho quipped dryly, his tone mixed with pragmatic concern. His eyes silently urged Seonghwa to go after you. 

Seonghwa stood there for a moment, clutching your heels, his mind racing. He couldn’t let you leave like this, not without explaining himself. Taking a deep breath to steady himself, he set out after you, determined to make things right.

“You did not fly all the way home without your heels,” Sunmi yawned, cradling Siwoo in her arms. Your nephew let out a string of babbles, his tiny face scrunched up as if he were reprimanding you for your forgetfulness.

“Just did,” you said with a shrug, lifting the skirt of your gown and wiggling your bare toes in the air. “I mean, it’s not like I planned to leave my heels there and honestly, I didn’t even notice until I got home,” you lied. 

Sunmi’s eyebrows knitted together in concern as she studied you. “What happened?” she asked, her voice softening. She shifted Siwoo to her other arm, his tiny head resting against her shoulder. The gentle rise and fall of his breathing seemed to mirror the rhythm of your own anxious heartbeats.

You sighed deeply, feeling the weight of the evening’s events, the exhaustion and emotional turmoil finally having caught up with you. “This happened,” you said, holding up the encyclopedia for her to see. The book felt heavy in your hands, not just in weight but in the significance of what it represented.

“I think I might’ve figured out the other half of Ajax’s pedigree. I didn’t have my own copy so I borrowed Jongho’s. I’m going to do some work,” you explained, determined to solve the mystery you’ve been chasing for months now. 

You retreated to your study, sliding into your desk chair. Your fingers trembled slightly as you flipped through the pages, each one filled with intricate illustrations and detailed descriptions of various dragon breeds. A sense of awe washed over you as you read through breeds, old and new—each more fascinating than the last. As you continued, your anticipation grew, until finally, your eyes landed on the page you were searching for. 

You studied the avian-looking dragon. Its sleek, streamlined body was adorned with grotesque feathers hanging from its gangly, mismatched wings. The large, bug-like eyes bulged with an eerie intelligence, giving the dragon an almost alien appearance. They stared back at you with a knowing, unsettling awareness. Its sharp, curved beak-like snout added to its avian resemblance, but instead of elegance, it exuded menace and predatory intent, as if ready to strike at any moment.

“Found you,” you whispered, a triumphant smile spreading across your face. Your mind raced with the implications of this discovery, the pieces of the puzzle finally coming together. As you scribbled notes on your scratch pad, thoughts of your job at the Institute surfaced; the resources and access you had there could be invaluable for digging deeper into the investigation and revealing the truth about Ajax. 

A sudden knock against your doorframe startled you from your thoughts. You blinked, momentarily readjusting your glasses to make sure you weren’t imagining things.

“Seonghwa?”

Seonghwa stood in the doorway to your office, the soft light from the lamp casting a glow that accentuated his sharp features and the depth in his eyes. The usual strands of his updo were windswept, adding a touch of wildness indicating that he wasted no time trying to find you. His tie hung loosely around his neck, its knot undone splayed over his chest–and your stilettos, with their long, thin heels hung from his hands. 

“You forgot these.” He held out the heels, his expression sheepish as his eyes darted between the shoes and your face. The contrast between his usually confident demeanor and the awkwardness of the gesture made him all the more endearing.

Your fingers brushed against his in a brief, electric touch. “Thank you,” you said, touched by his thoughtfulness. “You didn’t have to come all this way.”

He stepped closer, the scent of his cologne filling your senses, creating an intoxicating blend that heightened the tension between you. His eyes, usually so guarded, now held a vulnerability you’d never seen before.

“I realized I’d never see you again if I didn’t bring them,” he said, his words tumbling out quickly as if he feared losing the courage to say them. “And… I wanted to make sure you were okay.”

Seonghwa’s gaze lingered on you for a moment, taking in every detail of your appearance. He noticed your furrowed brow and the slight tilt of your head as you spoke. His eyes traced the curve of your neck to your collarbone, where the strapless black gown rested. The way the lamplight highlighted the contours of your features made him forget how to breathe.

“You haven’t changed out of your gown?” he asked, his voice softening with genuine curiosity and admiration.

You yawned and stretched slightly. “It’s too pretty to take off.”

“It suits you.” You felt a blush creep up your cheeks, and you looked away, trying to hide your smile.

“Guess I just didn’t want the night to end.” 

He took a deep breath, his chest rising and falling as he tried to steady himself. “I’m sorry, Y/N,” he said, his voice barely above a whisper.

You raised an eyebrow, feeling a knot form in your stomach. “What are you apologizing for?”

“I made a mess of things, and you got caught in the crossfire,” he confessed, his voice cracking. “Seeing you hurt because of what happened in the library has been eating away at me. I never, never meant to hurt you. It made me realize that I don’t want to lose you.”

His words hung in the air, heavy with regret and desperation. You could see the anguish in his eyes, the way his hands trembled slightly as he spoke. You looked down at the heels in your hands, feeling a swell of emotions rise within you before setting them down. 

“You’re only human, Seonghwa,” you said softly, despite the storm swirling within you. “We all make mistakes. What matters is that you’re here now, trying to make things right. So, thank you.”

You let the words settle between you before taking your own breath. “While you're here, I’m…thinking of going back to the Institute,” you say. “I think I’ve figured out Ajax’s missing half but I don’t think our case against the necropsy will be very effective if I don’t have access to all the necessary resources.” 

Seonghwa’s expression shifted from relief to a playful glint as he leaned in. “I bare my soul to you and you’re already leaving me?”

You scoffed. “I wouldn’t consider that soul baring,” you smiled, trying to ignore the flutter in your chest.

"Guess I'll have to visit you every day since you'll be close to the capitol," he murmured, his voice deep and teasing as he leaned in. “I don’t plan on letting you go back to Wooyoung that easily.” Seonghwa's hand takes hold of your face, his thumb sweeping across your jawline.

You welcomed his touch, yet the weight of your true feelings was almost too much to bear. A raw ache in your chest served as a painful reminder: Seonghwa was not yours, and he never would be. You had accepted this, even if it stung more than you were willing to admit. 

<< viii | daylight | x >>

taglist: @litolmochi @syubseokie @park-simphwa @szakias

[wtf-scientific-papers]

[Nitric oxide and synaptic plasticity: NO news from the cerebellum]

Vincent, 1996

[i-write-hurt-not-comfort]

in the defence of Ruki Mukami - why Ruki's trauma has just as much influence on his actions as everyone else

i am sitting in the chemistry library at uni right now and am going to spend my time on the most useless task ever to avoid doing anything impactful. please don't take this too serious because i can't write meaningful character analyses.

so i've seen a ton of stuff around, because i know Ruki's not one of the best loved characters in the western fandom. well, of all the characters, i see nearly the most Ruki hate. and obviously everyone is entitled to their opinions, whatever. but what DOES bother me is the reason.

a lot of people say that Ruki's trauma doesn't correlate to his actions, or explain abusive behaviour in the same way that the other characters' do. and i would die for Ruki and we know this, but i've thought about it a lot and i have a Theory as for why some people seem to view his character this way. (i have also studied neuroscience at degree level and learnt about trauma and synaptic plasticity)

to summarise for those who perhaps haven't read all the games (my sources for all this is basically Ruki's MB, DF, and LE), Ruki was born as an only-child in Romania to a rich family, and his father was revealed to be a politician during the Ceaușescu period in Romania. they had a lot of servants, all of whom Ruki learnt from a young age to abuse. he admired his father very much and looked up to him, and his mother was good to him and was close to his father. it would seem like a very good, perfect family - although i'll briefly discuss later why this wasn't necessarily the case.

unfortunately, in the DL universe lore, Karlheinz and Ceaușescu were buddy-buddy politicians, and Ruki's father was eventually chased out of his position. during his downfall, Ruki's father became an alcoholic and began abusing Ruki's mother, verbally and physically. Ruki saw a lot of this as well: somebody he looked up to, admired and trusted, becoming an abusive monster in a very short period of time. i think that's part of why Ruki overlooks Karlheinz's crimes and sees him as a good father anyway.

not only that, Ruki's mother - once again somebody who nurtured and cared for him - turned out to be having an affair. and shortly after that, his father committed suicide: something Ruki actually walked out on.

that in itself is a lot more traumatic than i think people consider. a lot of the DL characters have long-term trauma, but intense sudden trauma, such as your "perfect" life falling apart due to an alcoholic, abusive father killing himself and his mother having an affair, has similar psychological impact. remember, these are people who were supposed to care and nurture him, he trusted them a lot, and they both abandoned him abruptly in very extreme ways. that's the number 1 root of Ruki's trust issues. he's been seen to cut Yui off entirely because he's scared of becoming his abusive father.

similarly, living in a "perfect" household as a spoiled only child can be inherently traumatic. i don't know about you guys, but i've met some (only some, not the majority) of very, very emotionally constipated spoiled only-children. a lot of children showered with materialistic affection are missing key emotional maturity developments. their outlook on life is very narrow and they lack the emotional components of attachment; this is part of why Ruki is quite emotionally immature.

not only that, but growing up as an abusive sociopath to "lower" members of society such as servants is a form of abusive on his parents' behalf. they did not teach him proper world awareness. some children are born as psychopaths etc, true, but the majority of "sociopaths" (diagnosed as ASPD) are that way because they were not taught remorse as a child. Ruki would've learnt to treat his servants that way because that was how his parents did (and we see his father being a dick to the servants in LE too i think), and that in itself is inherently traumatic too.

imagine then, with very little capacity for remorse or a concept of societal hierarchy, being thrown into an orphanage. Ruki is a dick to everyone, yes, but the shock of having everything you know challenged suddenly and without explanation or support is going to cause further trauma. i think people just don't like to consider the fact that a lot of "sociopaths" (again, ASPD is the correct label there) were victims too. he went from being the "master" to being "livestock" and that's going to very rapidly alter your young brain chemistry, entering a "master" mindset as a defensive mechanism. that's why he gets angry/upset/confused when it's challenged.

Ruki has a fuck ton of PTSD as well - he's the only character who i've seen literally throw up MULTIPLE TIMES when experiencing flashbacks.

but i think people generally know that, perhaps not thinking about it as deeply. my Theory as to why people don't seem to see this as being as "extreme" as the other boys' trauma goes further than that.

diabolik lovers follows this dynamic between the Sakamaki's vs Mukami's, whereby Yuma, Kou and Azusa (Yuma and Kou more strongly) have this mindset of "the Sakamaki's can't have trauma because they were rich" and obviously as readers, we're supposed to be like "um, no, the Sakamaki's can have trauma too" because they do.

with that said, Kou and Yuma do successfully get to Subaru/Laito and Shu's heads respectively with this narrative. especially Subaru and Shu who get really fixated with this "i was a spoiled, privileged kid" and because of that, naturally we, as readers, lean towards feeling sorry for the Mukami's especially.

obviously, Ruki is the odd one out when it comes to the Mukami's. he had a sheltered upbringing whereas the other brothers were fighting for their lives in poverty/on the streets, victims and witnesses of the civil war and orphan crisis. Yuma particularly pushes this "Ruki had it easy" notion too, and i've definitely noticed that a lot of people who don't particularly like Ruki tend to fall towards that.

this idea of "not enough" trauma has enough to unpack as it is and we won't do that to, but personally i think that all of Ruki's abusive actions are justified. no, they are not an excuse. none of the diaboys' behaviour is excusable, but i think Rejet did quite a good job of giving them enough fucked up backstory to make us as readers at least understand why that might be how they act.

and from what i see, it seems to be Ruki who people think is the exception to this the most, because his trauma isn't in the same vein as the rest of the Mukami's. the "rich people can't have trauma" narrative gets pushed so hard that i think people forget 1) it isn't true and 2) Ruki went through a ton of fucked shit as a kid, and i don't think any of his actions made me feel any differently than the other diaboys' awful behaviour towards Yui.

you can find Ruki boring, not interesting, or just not your type. but he very, very much has "sufficient" trauma to explain his toxic and dominating actions. thank u for coming to my TedTalk.

[elicathebunny]

NEUROPLACISITY IN DEPTH.

(The content isn't mine but all complied into one big post, links are connected to the sources)

How do I re-wire my subconscious?

You re-wire your subconscious mind using NEUROPLASTICITY.

Neuroplasticity, also known as brain plasticity or neural plasticity, refers to the brain's ability to reorganize itself by forming new neural connections throughout life. It involves the strengthening or weakening of existing neural pathways and the development of new synapses.

This means you can re-wire your subconscious by building NEW PATHWAYS that become STRONGER than the old ones

I'd like you to start with understanding the importance of BDNF - Brain-derived neurotrophic Factor (BDNF) is a vital protein for neuroplasticity, acting as a linchpin in the adaptive processes of the brain. It supports facilitating synaptic plasticity through mechanisms like long-term potentiation (LTP) and fostering the formation of new synapses. You can increase your body's BDNF by:

Engage in regular exercise, particularly aerobic activities, to significantly increase BDNF levels and promote neuroplasticity.

Maintain a balanced diet rich in omega-3 fatty acids from sources like fatty fish and flaxseeds to support elevated BDNF production.

Prioritize adequate and quality sleep, as insufficient sleep has been linked to decreased BDNF levels.

Implement stress management techniques, such as mindfulness meditation and relaxation exercises, to positively influence BDNF secretion.

Breathwork and meditation are great options.

Understand the importance of regulating your nervous system - You must be able to regulate your nervous system to build neuroplasticity. This is because neuroplasticity may be hindered when the body is in a heightened state of stress or arousal (sympathetic dominance), characterized by increased heart rate and elevated cortisol levels. Breathwork and meditation are an incredible way to do this. Psych central

Take new routes: Every new experience has the potential to enhance your brain’s ability to change. Travelling, for example, can help. Our brains are forced to stop auto-piloting in an unfamiliar environment like a new city. Research from 2013 shows that novelty and challenges can enhance cognitive function. So, technically, you don’t have to leave your town to promote brain plasticity. Consider finding alternative routes to your daily commute. Try that new coffee shop or restaurant around the corner. Go around your desk in the opposite direction that you typically do.

Move: A 2018 literature reviewTrusted Source showed that physical exercise can promote neuroplasticity in general. Activity is beneficial for many different regions of the brain and affects various aspects of cognitive function, including memory and learning. This might be helpful for people facing major or mild cognitive decline, including Alzheimer’s disease. In sum, exercising may help you slow the cellular ageing process and enhance your overall brain health.

Practice meditation: Studies show that long-term meditation practiceTrusted Source can change the function of the brain. Specifically, mindfulness practice can enhance focus and attention and prevent cognitive declineTrusted Source.

Learn a new skill: The relationship between learning and neuroplasticity is twofold. Learning new things enhances brain plasticity, and because of the brain’s ability to adapt to change, you’re able to learn. In this sense, every time you learn something, you benefit from neuroplasticity and promote it. Research backs this up. A 2021 study, for example, suggests that learning a new skill, such as Braille language, can promote neuroplasticity and enhance its benefits. Other examples include learning to: - use your non-dominant hand - speak a new language - play a new instrument - paint or draw - code computers - do puzzles

[fluffydice]

If I ever wrote from Akechi’s point of view the best thing about it would be that even his inner dialogue would be him infodumping or knowing things about very specific interests, so I wouldn’t have to confine myself to the knowledge that “this character wouldn’t care nor know about synaptic plasticity :(“ because Akechi just might

[compneuropapers]

Interesting Papers for Week 44, 2024

The role of the human hippocampus in decision-making under uncertainty. Attaallah, B., Petitet, P., Zambellas, R., Toniolo, S., Maio, M. R., Ganse-Dumrath, A., … Husain, M. (2024). Nature Human Behaviour, 8(7), 1366–1382.

Modeling hippocampal spatial cells in rodents navigating in 3D environments. Aziz, A., Patil, B. K., Lakshmikanth, K., Sreeharsha, P. S. S., Mukhopadhyay, A., & Chakravarthy, V. S. (2024). Scientific Reports, 14, 16714.

Anterior cingulate cortex provides the neural substrates for feedback-driven iteration of decision and value representation. Chen, W., Liang, J., Wu, Q., & Han, Y. (2024). Nature Communications, 15, 6020.

Firing rate adaptation affords place cell theta sweeps, phase precession, and procession. Chu, T., Ji, Z., Zuo, J., Mi, Y., Zhang, W., Huang, T., … Wu, S. (2024). eLife, 12, e87055.4.

Non-Hebbian plasticity transforms transient experiences into lasting memories. Faress, I., Khalil, V., Hou, W.-H., Moreno, A., Andersen, N., Fonseca, R., … Nabavi, S. (2024). eLife, 12, e91421.3.

Gaze-centered gating, reactivation, and reevaluation of economic value in orbitofrontal cortex. Ferro, D., Cash-Padgett, T., Wang, M. Z., Hayden, B. Y., & Moreno-Bote, R. (2024). Nature Communications, 15, 6163.

Modulation of alpha oscillations by attention is predicted by hemispheric asymmetry of subcortical regions. Ghafari, T., Mazzetti, C., Garner, K., Gutteling, T., & Jensen, O. (2024). eLife, 12, e91650.3.

Contributions of cortical neuron firing patterns, synaptic connectivity, and plasticity to task performance. Insanally, M. N., Albanna, B. F., Toth, J., DePasquale, B., Fadaei, S. S., Gupta, T., … Froemke, R. C. (2024). Nature Communications, 15, 6023.

Consequences of eye movements for spatial selectivity. Intoy, J., Li, Y. H., Bowers, N. R., Victor, J. D., Poletti, M., & Rucci, M. (2024). Current Biology, 34(14), 3265-3272.e4.

Prediction error determines how memories are organized in the brain. Kennedy, N. G., Lee, J. C., Killcross, S., Westbrook, R. F., & Holmes, N. M. (2024). eLife, 13, e95849.3.

Neural Representation of Valenced and Generic Probability and Uncertainty. Kim, J.-C., Hellrung, L., Grueschow, M., Nebe, S., Nagy, Z., & Tobler, P. N. (2024). Journal of Neuroscience, 44(30), e0195242024.

Selective consolidation of learning and memory via recall-gated plasticity. Lindsey, J. W., & Litwin-Kumar, A. (2024). eLife, 12, e90793.3.

A synergistic workspace for human consciousness revealed by Integrated Information Decomposition. Luppi, A. I., Mediano, P. A., Rosas, F. E., Allanson, J., Pickard, J., Carhart-Harris, R. L., … Stamatakis, E. A. (2024). eLife, 12, e88173.4.

Memorability shapes perceived time (and vice versa). Ma, A. C., Cameron, A. D., & Wiener, M. (2024). Nature Human Behaviour, 8(7), 1296–1308.

Mixed Representations of Sound and Action in the Auditory Midbrain. Quass, G. L., Rogalla, M. M., Ford, A. N., & Apostolides, P. F. (2024). Journal of Neuroscience, 44(30), e1831232024.

Neural activity ramps in frontal cortex signal extended motivation during learning. Regalado, J. M., Corredera Asensio, A., Haunold, T., Toader, A. C., Li, Y. R., Neal, L. A., & Rajasethupathy, P. (2024). eLife, 13, e93983.3.

Using synchronized brain rhythms to bias memory-guided decisions. Stout, J. J., George, A. E., Kim, S., Hallock, H. L., & Griffin, A. L. (2024). eLife, 12, e92033.3.

Cortical plasticity is associated with blood–brain barrier modulation. Swissa, E., Monsonego, U., Yang, L. T., Schori, L., Kamintsky, L., Mirloo, S., … Friedman, A. (2024). eLife, 12, e89611.4.

Structural and sequential regularities modulate phrase-rate neural tracking. Zhao, J., Martin, A. E., & Coopmans, C. W. (2024). Scientific Reports, 14, 16603.

An allocentric human odometer for perceiving distances on the ground plane. Zhou, L., Wei, W., Ooi, T. L., & He, Z. J. (2024). eLife, 12, e88095.3.

[science-lover33]

Delving Deeper into Neuron Anatomy and Brain Functionality (Part 2)

Welcome back, Tumblr enthusiasts! In Part 1, we took our first steps into the neuron and brain universe. Now, let's journey further into their astonishing anatomy and intricate physiology. 🌌💡

Now that we've dived even deeper into the neuron's inner workings and explored more brain regions, I hope you're as captivated as I am by the wonders of neuroscience. Continue to feed your curiosity and stay tuned for more brainy adventures! 🧠

Neuron Anatomy (Continued)

Myelin Sheath: Wrapped around many axons, this fatty insulating layer is like the neuron's protective armor. It speeds up the transmission of electrical signals by allowing them to "jump" from one gap in the myelin sheath, called the Nodes of Ranvier, to the next. Think of it as a high-speed neural highway.

Schwann Cells and Oligodendrocytes: These specialized cells produce the myelin sheath. In the peripheral nervous system (PNS), Schwann cells individually wrap around axons. In the central nervous system (CNS), oligodendrocytes extend processes to multiple axons, forming myelin sheaths around them.

Sensory and Motor Neurons: Neurons aren't one-size-fits-all; they come in different shapes and sizes. Sensory neurons (afferent) bring sensory information from your body and surroundings to your brain and spinal cord. Motor neurons (efferent) carry commands from the brain and spinal cord to muscles and glands, allowing you to move and react.

Neuron Physiology (Continued)

Neurotransmitters: These chemical messengers are the key to communication between neurons. When an action potential reaches the axon terminals, it triggers the release of neurotransmitters into the synapse. These molecules bind to receptors on the neighboring neuron, initiating or inhibiting a new electrical signal, depending on the neurotransmitter type.

Synaptic Plasticity: Neurons can change the strength of their connections through a phenomenon called synaptic plasticity. This allows us to adapt and learn. Two important types include long-term potentiation (LTP), which strengthens synapses, and long-term depression (LTD), which weakens them.

Brain Functionality (Continued)

Thalamus: Often called the "relay station," the thalamus acts as a switchboard, directing sensory information (except for smell) to the appropriate regions of the cerebral cortex for further processing.

Hypothalamus: This small but mighty structure regulates many essential functions, including hunger, thirst, body temperature, and the body's internal clock (circadian rhythms).

Frontal Cortex: Located in the frontal lobes of the cerebral cortex, this region is responsible for higher cognitive functions like decision-making, planning, reasoning, and personality.

Temporal Lobes: These are crucial for auditory processing and memory. The hippocampus, nestled deep within the temporal lobes, is essential for forming new memories.

References

Purves, D., et al. (2017). "Neuroscience." Sinauer Associates, Inc.

Kandel, E. R., Schwartz, J. H., & Jessell, T. M. (2012). "Principles of Neural Science." McGraw-Hill Education.

[maaarine]

What Is Synaptic Pruning? (Jacquelyn Cafasso, Healthline, Sep 18 2018)

"Synaptic pruning is a natural process that occurs in the brain between early childhood and adulthood. During synaptic pruning, the brain eliminates extra synapses.

Synapses are brain structures that allows the neurons to transmit an electrical or chemical signal to another neuron.

Synaptic pruning is thought to be the brain’s way of removing connections in the brain that are no longer needed.

Researchers have recently learned that the brain is more “plastic” and moldable than previously thought.

Synaptic pruning is our body’s way of maintaining more efficient brain function as we get older and learn new complex information. (…)

This rapid period of synaptogenesis plays a vital role in learning, memory formation, and adaptation early in life.

At about 2 to 3 years of age, the number of synapses hits a peak level. But then shortly after this period of synaptic growth, the brain starts to remove synapses that it no longer needs.

Once the brain forms a synapse, it can either be strengthened or weakened.

This depends on how often the synapse is used. In other words, the process follows the “use it or lose it” principle: Synapses that are more active are strengthened, and synapses that are less active are weakened and ultimately pruned.

The process of removing the irrelevant synapses during this time is referred to as synaptic pruning. (…)

Unlike research into schizophrenia, which theorizes that the brain is “over-pruned,” researchers hypothesize that the brains of people with autism may be “under-pruned.”

Theoretically, then, this under-pruning leads to an oversupply of synapses in some parts of the brain.

To test this hypothesis, researchers looked at brain tissue of 13 children and adolescents with and without autism who passed away between ages 2 and 20.

The scientists found that the brains of the adolescents with autism had a lot more synapses than the brains of neurotypical adolescents.

Young children in both groups had roughly the same number of synapses.

This suggests that the condition may occur during the pruning process.

This research only shows a difference in synapses, but not whether this difference might be a cause or an effect of autism, or just an association.

This under-pruning theory may help explain some of the common symptoms of autism, like oversensitivity to noise, lights, and social experiences, as well as epileptic seizures.

If there are too many synapses firing at once, a person with autism will likely experience an overload of noise rather than a fine-tuned brain response."

[medicomunicare]

Cholesterol in brain network: how does its presence affects health or neurodegeneration?

Cholesterol in brain health and disease Cholesterol is found in the cell membranes of all human cells. It plays an integral role in neuronal signaling and synaptic connections, especially in the brain. Notably, the brain contains between 20-25% of all the body’s cholesterol reserves, making it the organ with the highest cholesterol concentration in the human body. Interestingly, peripheral…

[bpod-bpod]

Fuse and Rewire

Mitochondria (the energy-source organelles of a cell) fusing in newly developing neurons in adulthood plays a key role in synaptic plasticity – the strengthening and weakening of connections between neurons that underlies memory formation

Read the published research article here

Image from work by Sandra M.V. Kochan and colleagues

Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany

Image originally published with a Creative Commons Attribution – NonCommercial – NoDerivs (CC BY-NC-ND 4.0)

Published in Neuron, April 2024

You can also follow BPoD on Instagram, Twitter and Facebook

[teine-mallaichte]

Day 17 @whumpmasinjuly-archive : What has been your most recent whump obsession?

Sleep deprivation!

As someone with schizoaffective disorder, and so have a fair bit of experience with (hypo)manic episodes, in the hypomania I am often still somewhat aware of the situation and can go for days, week, on only an hour of two's sleep a night. I can even trigger mania by not sleeping - this made uni fun… As such sleep is a complex thing for me, something I forever struggle with but somehow have to obtain. So maybe that's why the concept fascinates me… but just think about it... Ever wonder what happens when you push your limits and stay awake for too long?

First 24 Hours:

Cognitive Function: Your attention, alertness, and concentration start to falter. Reaction times slow, and problem-solving skills take a hit.

Mood: Expect irritability and mood swings. Emotional regulation becomes a bit of a mess.

Physical Effects: Notice tired eyes, constant yawning, and a growing sense of fatigue.

1-2 Days (24-48 Hours):

Cognitive Decline: Your memory gets shaky, and decision-making becomes even tougher.

Physical Health: Your immune system takes a hit, making you more prone to infections.

Mood and Behavior: Increased moodiness, anxiety, and stress. You might even start feeling a bit paranoid or aggressive.

2-3 Days:

Cognitive Impairment: Severe disorientation and hallucinations can kick in.

Physical Effects: Coordination and motor skills drop. Overall physical performance declines.

Sleep Deprivation Psychosis: Some might experience delusions and severe psychosis symptoms.

3-7 Days:

Brain Function: The frontal lobe (for executive functions) and limbic system (emotions) are severely impacted.

Health Risks: Chronic sleep deprivation can worsen physical health issues like hypertension and diabetes.

Emotional and Mental Health: Persistent mood swings, severe anxiety, and depression set in. Cognitive function is heavily compromised.

Beyond 1 Week:

Cognitive and Emotional Health: Long-term risks include serious cognitive impairments and mental health disorders.

Physical Health: More severe conditions like metabolic disorders and weakened immune function can develop.

Fun Fact: The record for staying awake without sedatives is 11 days! 🤯 Imagine what they went through to achieve this!

Also, I studied the brain for years, and anything that effects it kind of fascinated me... so, on that topic, I'm going to leave you with a bit of a (very much cut down but if you want anything expanding just ask) science dump: Cognitive Function and Brain Structures:

Frontal Lobe: Handles decision-making and impulse control. Sleep deprivation impairs this, leading to poor judgment.

Hippocampus: Essential for memory. Lack of sleep messes with memory formation and consolidation.

Amygdala: Manages emotions. With sleep deprivation, it becomes hyperactive, increasing stress and emotional instability.

Neurotransmitters & Neurochemicals:

Cortisol: Rises with sleep deprivation, ramping up stress and anxiety.

Serotonin & Dopamine: Imbalances can lead to mood swings and depression.

Adenosine: Builds up during wakefulness and promotes sleep pressure. Too much leads to a “sleep rebound” effect.

Neural Connectivity & Brain Systems:

Synaptic Homeostasis Hypothesis: Sleep helps balance synaptic connections. Deprivation disrupts this, affecting learning and memory.

Brain Plasticity: Sleep is crucial for brain reorganization. Lack of it impairs this ability.

Default Mode Network (DMN): Disrupted by sleep deprivation, making introspection and self-reflection difficult.

Reward System: Deprivation can mess with pleasure and risk-taking behaviors.

Whumpmas In July 2024 posts