#transcription factor

[bpod-bpod]

Cardiac Mechanic

Biomechanical forces sculpt tissue during development: this study in zebrafish shows that a protein (transcription factor) called egr3 is vital for sensing such forces, turning them into molecular cellular signals regulating the development of heart valves

Read the published research article here

Image from work by Agatha Ribeiro da Silva and colleagues

Max Planck Institute for Heart and Lung Research, Department of Developmental Genetics, Bad Nauheim, Germany

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in Science Advances, May 2024

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[medicomunicare]

TRPS1 as possible unique biomarker for triple-negative? Investigations on cellular biology and mechanisms

The mammary gland is a complex tissue comprising a variety of cell types. Their proper functioning is crucial for the health of the breast. Breast cancer is the widest condition affecting breast health and can be categorized as estrogen receptor (ER)/progesterone receptor (PR)-positive luminal, human epidermal growth factor receptor 2 (HER2)-positive, or triple-negative breast cancer (TNBC) types…

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The heat shock response appears to be mediated by one or more signal transduction pathways, one of which involves a specific set of transcription factors, called heat shock factors, that regulate the transcription of HSP mRNAs.

"Plant Physiology and Development" int'l 6e - Taiz, L., Zeiger, E., Møller, I.M., Murphy, A.

[whats-in-a-sentence]

For example, evolution has recruited the same transcription factor, APETALA2, to first regulate floral meristem identity and then floral organ identity (Table 20.3). (...) In Arabidopsis, LEAFY (LFY), FLOWERING D (FD), SUPPRESSOR OF OVEREXPRESSION OF CONSTANS1 (SOC1), and APETALA1 (AP1) are among the critical genes in the genetic pathway that must be activated to establish floral meristem identity (see Table 20.3). (...) Many of the genes that determine the floral organ identity are MADS box genes, including the DEFICIENS gene of snapdragon and the AGAMOUS (AG), PISTILLATA (PI), and APETALA3 (AP3) genes of Arabidopsis (see Table 20.3).

"Plant Physiology and Development" int'l 6e - Taiz, L., Zeiger, E., Møller, I.M., Murphy, A.

[seventh-district]

not even gonna tag this properly bc i don't wanna get Involved but i do have some Thoughts i need to get out into the void so here we go

(aaa quick edit: CW for mention/discussion of Boothill leaks)

[theresa-of-liechtenstein]

well. ok then :/

[martyrbat]

fine... downloading batman 66 episodes and writing the transcripts as we speak. just for you guys (gn) <3

[unopenablebox]

thinking about goosecoid again

[auphelia]

Happy transcription factor Tuesday - this is RORyt, my favourite

[innonurse]

The most extensive collection of transcription factor binding data in human tissues ever compiled

- By InnoNurse Staff -

Transcription factors (TFs) are proteins that bind to specific DNA sequences to regulate the transcription of genetic information from DNA to mRNA, impacting gene expression and various biological processes, including brain functions. While TFs have been studied extensively, their binding dynamics in human tissues are not well understood.

Researchers from the HudsonAlpha Institute for Biotechnology, University of California-Irvine, and University of Michigan compiled the largest TF binding dataset to date, aiming to understand how TFs contribute to gene expression and brain function. This dataset could reveal how gene regulation impacts neurodegenerative and psychiatric disorders.

The study, led by Dr. Richard Myers, utilized an innovative technique called ChIP-seq to capture and sequence DNA fragments bound by TFs. Experiments were conducted on different brain regions from postmortem tissues donated by individuals, allowing the researchers to map TF activity in the genome.

Findings suggest that regions bound by fewer TFs might be crucial, as minor changes there could significantly impact nearby genes. The dataset can help scientists study TFs, gene regulation, and their roles in specific brain functions and diseases, potentially aiding in the development of new therapies.

Image credit: Loupe et al. (Nature Neuroscience, 2024).

Read more at Medical Xpress

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Other recent news and insights

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Wearable sensors and AI aims to revolutionize balance assessment (Florida Atlantic University)

[bpod-bpod]

Reprogramming Scars

After a heart attack, cardiac fibroblasts (shown) immediately patch up the damage to save the tissue. But, the scar they form is tough and non-contractile meaning the heart’s pumping function is compromised, which can ultimately result in its failure. To improve outcomes of patients after heart attacks, scientists are investigating in mice ways to reprogram the fibroblasts into muscle. The problem is, adult fibroblasts are particularly reluctant to change – in part, it seems, because of a transcription factor called Epas1 (stained red). But, a cocktail of RNA molecules that block Epas1 and promote muscle identity seems to do the trick. When scientists packaged this cocktail into membrane-bound droplets (called exosomes) and delivered them to the injured hearts of mice, the fibroblasts reprogrammed, scarring was reduced and heart function improved. If such an approach can be adapted for humans, it may help to maintain heart function and prolong life after a heart attack.

Written by Ruth WIlliams

Image from work by Hualing Sun and colleagues

Mandel Center for Heart and Vascular Research, and the Duke Cardiovascular Research Center, Duke University Medical Center, Durham, NC, USA

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in Journal of Biological Chemistry, April 2023

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[medicomunicare]

Resisting arrest: ribosomials, oncogenes, tumor suppressors and enzymes coordinate to induce cell suicide in leukemia

Acute lymphoblastic leukemia (ALL) is a highly aggressive cancer. Numerous genetic subtypes of ALL have been identified, including Philadelphia chromosome-positive B-cell ALL (Ph+B ALL) which comprises approximately 25-30% of all adult ALL. Ph+B ALL is characterized by the t(9;22) chromosomal translocation that generates the BCR-ABL1 fusion gene resulting in abnormal tyrosine kinase signaling in…

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JAZ repressors also maintain the chromatin in a "closed" state that prevents JA-responsive transcription factors from binding to their agents.

"Plant Physiology and Development" int'l 6e - Taiz, L., Zeiger, E., Møller, I.M., Murphy, A.

[whats-in-a-sentence]

TRY is expressed in developing trichomes and moves to the surrounding cells, where it inactivates the GL1-GL3-TTG1 complex by displacing GL1 (Figure 19.14). (...) GL2, which is activated in trichome cells by the GL1-GL3-TTG1 complex, encodes a homeodomain leucine zipper transcription factor (see Figure 19.14). (...) Also, jasmonic acid participates in trichome initiation by degrading JAZ proteins, thereby abolishing the interactions of JAZ proteins with bHLH and MYB factors, which activate the transcription of trichome activators (see Figure 19.14).

"Plant Physiology and Development" int'l 6e - Taiz, L., Zeiger, E., Møller, I.M., Murphy, A.

[pebblegalaxy]

Unlocking the Mysteries of Gene Expression: From Genomic Imprinting to Non-Coding RNAs in Biology Class with Dr. Mishra

Unlocking the Mysteries of Gene Expression: From Genomic Imprinting to Non-Coding RNAs in Biology Class with Dr. Mishra #GeneExpression #BiologyClass #GenomicImprinting #NonCodingRNAs #CollaborativeLearning

Dr. Mishra: “Hello there! I see we have a new face in our biology class today. Welcome! We’re so glad you’re here, and I want you to know that this classroom is a friendly and supportive place. If you ever have questions or need assistance, don’t hesitate to ask me or your classmates. We’re all here to learn together and make this an enjoyable experience for you.” Abby: “Hello. My name is Abha…