#transcription factor
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Cardiac Mechanic
Biomechanical forces sculpt tissue during development: this study in zebrafish shows that a protein (transcription factor) called egr3 is vital for sensing such forces, turning them into molecular cellular signals regulating the development of heart valves
Read the published research article here
Image from work by Agatha Ribeiro da Silva and colleagues
Max Planck Institute for Heart and Lung Research, Department of Developmental Genetics, Bad Nauheim, Germany
Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)
Published in Science Advances, May 2024
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#science#biomedicine#immunofluorescence#biology#zebrafish#transcription factor#heart valves#heart#developmental biology#biomechanics
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AP-1: a keymaster FOStering the JUNction among several tissues by wERKing on the MAPk
AP-1: ID and biological functions AP-1 (Activator Protein-1) is a transcription factor that plays a key role in regulating gene expression involved in a wide range of cellular processes, including proliferation, apoptosis, differentiation and stress response. AP-1 is a protein complex composed mainly of members of the Fos (c-Fos, FosB, Fra-1, Fra-2) and Jun (c-Jun, JunB, JunD) protein families,…
#angiogenesis#betulinic acid#boswellic acids#cancer cells#celastrol#cellular proliferation#curcumin#EGCG#metalloproteinases#neurodegeneration#neuroplasticity#oncogenesis#proto-oncogene#quercetin#resveratrol#synaptic plasticity#transcription factor
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youtube
#Lung cancer#Aiolos#OTUB1#ubiquitination#oncogenesis#cancer research#cell proliferation#protein stabilization#tumor progression#cancer therapy#molecular mechanisms#deubiquitinase#proteasomal degradation#cancer biomarkers#targeted therapy#signal transduction#metastasis#transcription factor#oncogenic pathways#tumor biology.#Youtube
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The heat shock response appears to be mediated by one or more signal transduction pathways, one of which involves a specific set of transcription factors, called heat shock factors, that regulate the transcription of HSP mRNAs.
"Plant Physiology and Development" int'l 6e - Taiz, L., Zeiger, E., Møller, I.M., Murphy, A.
#book quote#plant physiology and development#nonfiction#textbook#heat shock#signal transduction#transcription factor#heat shock factors#regulation#hsp#heat shock proteins#mrna
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For example, evolution has recruited the same transcription factor, APETALA2, to first regulate floral meristem identity and then floral organ identity (Table 20.3). (...) In Arabidopsis, LEAFY (LFY), FLOWERING D (FD), SUPPRESSOR OF OVEREXPRESSION OF CONSTANS1 (SOC1), and APETALA1 (AP1) are among the critical genes in the genetic pathway that must be activated to establish floral meristem identity (see Table 20.3). (...) Many of the genes that determine the floral organ identity are MADS box genes, including the DEFICIENS gene of snapdragon and the AGAMOUS (AG), PISTILLATA (PI), and APETALA3 (AP3) genes of Arabidopsis (see Table 20.3).
"Plant Physiology and Development" int'l 6e - Taiz, L., Zeiger, E., Møller, I.M., Murphy, A.
#book quotes#plant physiology and development#nonfiction#textbook#evolution#transcription factor#snapdragon#arabidopsis#mads box genes#deficiens#constans#flowering d#suppressor of overexpression of constans#soc1#phytochrome interacting factor#pif4#short vegetative phase#svp#flm#flc#flowering locus#leafy#lfy#apetala#ap1#ap2#ap3#pistillata#agamous#sepallata
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funny how this fic started off as an "unserious" idea (not cracky, more so i didn't take it that seriously, it was basically so i could rotate certain characters from my head into a google doc), i didn't expect to care abt it as much as i do now like i have a basic chapter layout for half of the set chapter count, specific scenes prewritten, a planning doc with around five pages thus far, the basics (title, summary, etc), random scenes for it spinning around in my head, and a bit of chapter one and three pages of chapter four written 😭
and i started properly thinking stuff for and working on this fic like...two days ago
it was not supposed to be This Serious hfjkdhf
#(this reminds me of how unserious i initially took picking petals but then it turned into All That lmaoo)#literally shoved some of my fav reboot rarepairs in this lmao#i think the reason why i havent made more progress with the chapter prewriting is bc college is kicking my ass i hardly get free time 😭#and also there arent any transcripts for s2 of the reboot :(#had to do psychology and mental health research for one of the characters for a hc and although i wanna incorporate it im hesitant#bc i dont wanna fuck it up somehow. but also im doing more research in case i think of another idea for them#i might go for it tho. we'll see. if i do its gonna further the angst bc some Baggage goes with it but stuff will wrap up too#so far whenever i think abt them i use that sort of lens anyway#so either i do it fully or aspects are implied via connective factors like environmental surroundings#either way it will involve that specific idea i have thought up to some degree#anyway im halfway thru s2 and taking notes for the fic while watching (i was planning on watching first then rewatching while outlining-#-buuut im too pumped lmao i see scenes and go 'oh imagine if i change it up a little in the fic' etc etc and then i just gotta jot it down)#the elimination order is tearing my hair out tho bc i love the cast but s2's elimination order was Not It i def gotta change that#ugh so much planning 😭 it was NOT this difficult with picking petals#(could be bc tdpi is my fav cast to write for)#sigh. lets see how it goes! and if I'll even publish this anytime soon lmao#kit writes#kit stuff#noahtally-famous#(....also dw ygs i know i rlly gotta finish agtsta's next chapter too-)
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not even gonna tag this properly bc i don't wanna get Involved but i do have some Thoughts i need to get out into the void so here we go
(aaa quick edit: CW for mention/discussion of Boothill leaks)
#today's gone Badly and i'm upset but instead of venting abt it i'm gonna channel that energy into doing a bit of tag rambling abt Boothill#well. less abt Him and more abt uh. self-analyzing my anxiety surrounding contributing to fandoms. he's just today's catalyst#like. i know it's mostly a me thing. i'm hypersensitive to criticism and very conflict avoidant + socially anxious + perfectionistic etc.#so I'm the one that keeps myself from posting more stuff out of fear of being criticized or called-out for what i've made#bc inevitably Someone's gonna see it and think its OOC or a problematic take or they'll misread my intent. etc etc what have you#but like. that's inevitable. there's no way to communicate every single thing with all of the nuance required to avoid misunderstandings#and other times it's not a misunderstanding it's just a difference of opinions and that's Fine!! there's no accounting for personal taste#there's no accounting for several things actually. taste‚ bias‚ lore-knowledge‚ differing levels of chronic-online-ness‚ etc#so this isn't me complaining abt the state of fandom culture (although i do think. sometimes. ppl take shit a bit too seriously)#but anyways all of this is mostly just anxiety-fueled. it's not like i very often actually even receive negative feedback or anything#if anything ppl tend to tell me that i'm overthinking it and killing my own fun and worried that my stuff is more OOC than it is#which like. yeah. Yeah u right :) but that's just the way that i am! always losing the idgaf war i suppose#anyways what's Boothill got to do w this ur wondering. well. i've been thinking abt the quickly emerging concept that he's illiterate.#and it just. has me feeling a lot of ways. and watching ppl disagree over it has me feeling some Bad ways. bc it's def a loaded topic!#if you'll pardon the pun there. and i don't rlly have anything new to add other than that i'm conflicted abt it.#like yeah i saw the leaks days ago. of him mentioning 'not hitting the books' much as a child when we ask him why he sends voice messages#or voice Transcriptions ig. ykwim. and like. *braces for impact* ...i liked it? like. it doesn't feel right to call it endearing#i'm not trying to infantilize him. ok that's not the right word either but ugh. you know? what i mean?? who am i kidding even i don't know#it's not quite right to say that it feels like Representation either. but it's something close i guess#as a southern person myself who didn't receive a 'complete' education due to factors that weren't to do with my intelligence#the concept of seeing him as a capable force to be reckoned with and respected who also happens to have not received much formal education#i like that. i do. but there's so many issues w it at the same time. like. as i said‚ being southern myself has me Wary of the way Hoyo is-#writing him. as well as of the way that the fandom is taking the bits of his lore and running away w them. and i'm Very aware of how ppl-#will see a southern character and be All Too Eager to agree that they're lacking intelligence based on our Redneck™ stereotype#sigh. and before we even go too far with this. it's not even confirmed that hes completely illiterate. which is a valid criticism i've seen#there's Multiple reasons that could make him prefer voice to text. but regardless. i'm just worried that ppl will misconstrue my intentions#like. example: that edit i made the other day of him saying 'no thanks i can't read'. wasn't me playing into the stereotype of-#'haha dumb country boy can't read!' it was. in my eyes. something he'd say as a joke to make light of a potential insecurity#like. i think there's far more depth to Boothill's character if ppl could look past the surface. and i dont wanna contribute to the problem#but sometimes ppl Will have stereotypical traits and i wish the same could apply to characters as long as it's done Thoughtfully.
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well. ok then :/
#and i thought i did well this quarter.#i mean except for the mechanical engineering class. i thought i’d just get a B in that#i didn’t think it would be as bad as a B-#the mechanical engineering department’s grading scale has NEVER worked in my benefit#anyways oh well. gonna have to send this version of the unofficial transcript to the last three programs unfortunately#i’m not sure how much the honors project credits will help my gpa but the chances of me getting dean’s list are woefully slim#yeah yeah gpa is a small factor holistic evaluation whatever I’m Still Insecure About My Grades. what about it.#iskul bukol: undergrad edition
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fine... downloading batman 66 episodes and writing the transcripts as we speak. just for you guys (gn) <3
#this will be great because i have an issue with allowing myself to watch things because i feel guilty anytime im happy#<- not unpacking that stay with me here ->#so this is a little mental loophole. i GOTTA watch it so i can write the transcript and have it be accessible while sharing with my friends#so if i HAPPEN to enjoy the show too? thats just a pleasant added factor
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thinking about goosecoid again
#named because it looks like the genes 'gooseberry' (named because it causes extra fly larva bristles)#and 'bicoid' (???)#you know. fusions#similarities#et cetera.#box opener#homeobox#< the kind of transcription factor all of these genes are! as well as my charming box-themed category tag!
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Reprogramming Scars
After a heart attack, cardiac fibroblasts (shown) immediately patch up the damage to save the tissue. But, the scar they form is tough and non-contractile meaning the heart’s pumping function is compromised, which can ultimately result in its failure. To improve outcomes of patients after heart attacks, scientists are investigating in mice ways to reprogram the fibroblasts into muscle. The problem is, adult fibroblasts are particularly reluctant to change – in part, it seems, because of a transcription factor called Epas1 (stained red). But, a cocktail of RNA molecules that block Epas1 and promote muscle identity seems to do the trick. When scientists packaged this cocktail into membrane-bound droplets (called exosomes) and delivered them to the injured hearts of mice, the fibroblasts reprogrammed, scarring was reduced and heart function improved. If such an approach can be adapted for humans, it may help to maintain heart function and prolong life after a heart attack.
Written by Ruth WIlliams
Image from work by Hualing Sun and colleagues
Mandel Center for Heart and Vascular Research, and the Duke Cardiovascular Research Center, Duke University Medical Center, Durham, NC, USA
Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)
Published in Journal of Biological Chemistry, April 2023
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#science#biomedicine#immunofluorescence#heart attack#cardiac#fibroblasts#exosomes#transcription#transcription factor#heart function
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Aminoacids and fats meet for "malignant" purposes: reexploring antipsychotic drugs paving the way for metabolic wreck
Glioblastoma (GBM) is the most lethal brain tumor, with a median survival rate of merely 12-16 months after diagnosis. Despite surgical, radiation and chemotherapy treatments, the two-year survival rate for GBM patients is less than 10%. Two major challenges hinder effective treatment: the limited penetration of anti-tumor drugs into GBM tissues because of the blood-brain-barrier; and the rapid…
#aminoacid deprivation#brain cancer#fatty acid synthesis#glioblastoma#glutamine#lysosome#mitochondria#pimozide#transcription factor
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JAZ repressors also maintain the chromatin in a "closed" state that prevents JA-responsive transcription factors from binding to their agents.
"Plant Physiology and Development" int'l 6e - Taiz, L., Zeiger, E., Møller, I.M., Murphy, A.
#book quote#plant physiology and development#nonfiction#textbook#ja#jasmonic acid#chromatin#jaz#jasmonate zim domain#transcription factor
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This. This is exactly how I feel about fMRI and why I hate it so much. I mean, it doesn't help that I trained in EEB-style neuroscience so I default to wanting to know about differential gene expression and receptor expression patterns and knowing exactly what proteins are doing what when and how, none of which fMRI is ever going to show you: it's explicitly a technique that is all about the blood flow changes, and there's quite a lot of types of activity that can't be captured by that. Not to mention assumptions about blood flow matching 1:1 with activity. Like, cFOS drives me nuts, too—I have sharply asked SO MANY PEOPLE to tell me what the cFOS protein actually DOES in neuroscience settings and gotten a wide array of blank and terrified stares—but at least you actually are looking at a fucking protein there.
I just want to know what the cells are doing and how they're interacting with various signaling networks on the fly. Opto techniques work fairly well for that but for fairly obvious reasons (they involve either working with germ-line genetically modified subjects or injecting retroviruses designed to modify gene expression directly into the brain) they're not great for human use.
Any time sometime uses "activation" to refer to a brain, though, you march up to them and you ask exactly what "activated" means in this context anyway. There are at least half a dozen things people collapse under that term and they really, really oughtn't.
one of the best academic paper titles
#Also if you say cFOS is a “housekeeping gene” I'm going to come at you#It's a transcription factor.#HOUSEKEEPING IS NOT A FUNCTION JFC
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TRY is expressed in developing trichomes and moves to the surrounding cells, where it inactivates the GL1-GL3-TTG1 complex by displacing GL1 (Figure 19.14). (...) GL2, which is activated in trichome cells by the GL1-GL3-TTG1 complex, encodes a homeodomain leucine zipper transcription factor (see Figure 19.14). (...) Also, jasmonic acid participates in trichome initiation by degrading JAZ proteins, thereby abolishing the interactions of JAZ proteins with bHLH and MYB factors, which activate the transcription of trichome activators (see Figure 19.14).
"Plant Physiology and Development" int'l 6e - Taiz, L., Zeiger, E., Møller, I.M., Murphy, A.
#book quotes#plant physiology and development#nonfiction#textbook#try#trypticon#trichomes#plant cells#gl1#gl3#ttg1#glabra#transparent testa glabra#gl2#leucine#transcription factor#jasmonic acid#jaz#jasmonate zim domain#proteins#bhlh#basic helix loop helix#myb#myeloblastosis
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are you being quizzed on embryogenesis?
partly!! you may actually be totally right because i don't think the pictures i showed have anything other than embryogenesis terms, but I'm studying the whole developmental biology suite of content, ranging from evolutionary influences to development disorders and embryogenesis! not sure when other countries have there end of year exams, but in Australia we have them roughly now! this one is my last exam for the year <3
#phosphor makes noises#im actually super lucky i only had 2 exams from 4 subjects#because we did some MASSIVE assignments through the semester haha#asks#the content is SO DENSE though transcription factors why do you have such silly names
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