#pgc

[classicalliberalleague]

Remember PGC? Well she's baaaaack. Not the C part though, because that was a phase in her dumb 20s. She's in her 30s now, with an MA in history, a certificate in Gender and Public Policy, and an actual literary agent working to get her a book deal on the impact of nostalgia on politics and public policy.

Follow her at @notyourstepfordhistorian for her new content. (Also subscribe to her podcast at Bitchyhistory.com, and follow her on tiktok and instagram.

[strange-sim]

Conure

Disciplined, Excitable, Frugal, Slob, Shy Physical Perfection

download

[sunday-ruby]

a sudden frenzy for farming has taken over pgc

[gammaliminal]

i was Bored and i cant work on the technical side of PGC rn so uhhh here's more background characters!!:

The Dispatcher - Quartermaster of armaments, and new armaments, plus the previous PA, occasionally plans the Contractor's non-match missions - Aligned with 3RD - Can go into the field if needed with their suitcase of tricks, but will their ass handed to them by even the Exo outside of her suit The Intern - Newly hired just out of college with her 3 engineering degrees, works as the Technician's assistant and apprentice - Aligned with ORG/PNK - Refuses on principle to go out into the field, the Tech is too nice to force her The Courier - He delivers gear, mail, and notes from upper managment to the Contractors through drones and occasional in-person delivery - Aligned with ORG/PNK - Refuses to go out into the field without drones, but drones are pretty good for defense n such The Driver - A mostly silent ex-mafiaso, working as a driver for the various people - Aligned with 3RD - Goes out into the field occasionally armed with the classic drum-mag Thompson M1

they might get proper places in the cast list + proper emblems idk, we'll see

also, rotating the idea of having an unassigned team that's aligned with 3RD... maybe a specific gamemode with the background characters...

[codenamesticky]

I need a gym partner in the DMV area!

[pinocchiogangclub]

Pinocchio Gang Club tags explained 📌

This note has the purpose to clarify the meanings of the tags

#PGC : Pinocchio Gang Club

Sub tags

#PGCfanart : Pinocchio’s Fanart

#PGCognovel : Original Novel (any editions)

#PGCmovies : Movies and Series Adaptation

#PGCdisney : Disney Pinocchio

#PGCgdt : Guillermo del Toro Pinocchio

#PGCau : Alternative Universe

#PGCfc : Fan Characters (OCs)

#PGCfcfan : Fanarts of Fan Characters

Tags below for quick search

[butter-pangcake]

AAAAAAAAAAAAAAAAAAAAAAAAAAAAA

HE

😭😭😭😭😭😭😭😭

[quiltofstars]

"The Glowing Hand of God", GC 4 // David Néel

The "hand" appears to be reaching towards the background galaxy PGC 21338.

[monets-pixels]

heir vs spare treatment

[strange-sim]

Swallow

Excitable, Absent-Minded, Eco-Friendly, Cat Person, Daredevil Made The Most Of My Time

download

[sunday-ruby]

[gammaliminal]

Smol rant on how Armor works in PGC (no one asked but ehh who cares)

Armor works a lot like a separate health bar, absorbing 50% of the damage taken, but only getting refreshed by ammo packs.

Acid, fire, electricity, and melee pierces armor, dealing 100% damage to both armor and health. Crits also pierce armor meanwhile minicrits makes it so armor absorbs only 30%

(numbers aren't exact!)

[anneliesembsims]

A burglar was foolish enough to come to our house.

[blueoaknx]

Reclaim Vitality: The Science Behind Mitochondrial Biogenesis

Mitochondrial biogenesis is the cellular process of increasing the number of mitochondria, the organelles responsible for generating energy. This process is essential for maintaining cellular health and vitality, particularly in tissues with high energy demands, such as muscles. Mitochondrial biogenesis is often triggered by increased energy demand, usually resulting from exercise, caloric restriction, or the intake of specific nutrients.

Mitochondria are the energy producers of the cell, generating ATP, the energy currency of the cell, through oxidative phosphorylation. As cells face greater energy demands, they need more mitochondria to meet these requirements efficiently. The increase in mitochondrial numbers allows cells to produce more energy and better adapt to stress, thus enhancing overall health, recovery, and performance.

Key Factors Involved in Mitochondrial Biogenesis

Several molecular regulators drive mitochondrial biogenesis, with the most important being:

PGC-1α ActivationPGC-1α (Peroxisome proliferator-activated receptor gamma coactivator 1-alpha) is recognized as the master regulator of mitochondrial biogenesis. This protein plays a pivotal role in controlling the transcription of nuclear genes that encode mitochondrial proteins. When activated by external stimuli like exercise, PGC-1α interacts with transcription factors like NRF-1 and NRF-2 to drive the production of new mitochondria. This results in increased mitochondrial DNA (mtDNA) replication and the synthesis of mitochondrial proteins necessary for energy production and cellular respiration.

AMPK & SirtuinsAMPK (AMP-activated protein kinase) is another critical regulator that responds to low energy levels within the cell (a high AMP ratio). It activates PGC-1α, which, in turn, increases the number of mitochondria. AMPK is activated during energy-demanding activities such as endurance exercise and fasting. Sirtuins (SIRT1) are a class of NAD+-dependent enzymes that also regulate mitochondrial biogenesis. Sirtuins, especially SIRT1, deacetylate PGC-1α, further activating it to promote the transcription of mitochondrial genes. Both AMPK and sirtuins respond to energy deprivation, whether through physical exertion or caloric restriction, helping cells increase energy efficiency and prolong cellular longevity.

Antioxidant Defense and Cellular ResilienceOne of the benefits of mitochondrial biogenesis is the enhancement of cellular resilience through improved antioxidant defences. Mitochondria are not only energy producers but also sources of reactive oxygen species (ROS), which can damage cells if not adequately managed. By increasing the number of healthy mitochondria, cells improve their ability to manage oxidative stress. New mitochondria are typically more efficient at energy production and less likely to produce excess ROS, reducing overall cellular damage. This process helps to protect cells from age-related decline and stress-induced damage.

How Mitochondrial Biogenesis Impacts Health and Performance

Mitochondrial biogenesis is essential for maintaining optimal energy production, particularly during periods of increased physical activity or stress. In muscle cells, the increased number of mitochondria leads to improved ATP generation, enhancing endurance and reducing fatigue during prolonged exercise. This is particularly important for athletes or individuals who engage in regular physical activity, as their muscles require a constant supply of energy for performance and recovery.

For general health, mitochondrial biogenesis supports metabolic efficiency and longevity. In metabolic disorders like type 2 diabetes and obesity, mitochondrial dysfunction often results in impaired energy metabolism and increased oxidative stress. By promoting mitochondrial biogenesis, cells can restore normal mitochondrial function, improving insulin sensitivity and energy balance. Furthermore, mitochondrial biogenesis may help reduce the risk of chronic diseases related to ageing by maintaining cellular energy production and reducing oxidative stress.

Beyond exercise and metabolic health, mitochondrial biogenesis is also a key factor in the body’s ability to adapt to various stressors, whether environmental or nutritional. The increase in mitochondrial capacity allows cells to better handle changes in energy demand, supporting recovery and cellular adaptation. For instance, during periods of caloric restriction, mitochondrial biogenesis helps the body use energy more efficiently, contributing to longer-term health benefits, including improved longevity and resistance to age-related diseases.

Supporting Mitochondrial Biogenesis with Nutraceuticals

In addition to lifestyle factors like exercise and caloric restriction, certain nutraceuticals can support mitochondrial biogenesis. Mitokatlyst™-E is one such product that targets mitochondrial function, optimising energy production, and promoting muscle recovery. By stimulating the molecular pathways involved in mitochondrial biogenesis, such products can enhance the body’s ability to adapt to stress, recover more efficiently, and improve overall cellular function.

Conclusion

Mitochondrial biogenesis is a vital process that supports energy production, cellular health, and adaptability to environmental and physical stressors. By regulating pathways such as PGC-1α, AMPK, and sirtuins, cells can increase mitochondrial content to meet higher energy demands, promote muscle recovery, and improve overall vitality. Products like Mitokatlyst™-E are designed to optimise mitochondrial function, helping the body adapt to stress and maintain optimal cellular health. By supporting mitochondrial biogenesis, we can improve energy efficiency, enhance physical performance, and promote long-term health and resilience.

[butter-pangcake]

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAa

the question is who's his partner-

THANK YOU VERY MUCH

[monets-pixels]

Baby 13, Vulture Goth! (thanks to @indigoelfinspirit for the name suggestion back in December when Dodo was born)