#news are a no-go obviously

[rainbowsuitcase]

Every time I rewatch TFATWS, I can't help but notice - Bucky has the TV on. He's waking up from a nightmare to a turned on TV and since he doesn't have roommates, it's probably safe to assume he left it like that on purpose.

We know why he's sleeping on the floor, Steve had the same problem, the bed is too soft. But there's another reason why he's sleeping in the living room, and why the TV is on, and especially on something as neutral as a sports channel.

I wonder if it's simply because he hates the quiet. If his mind wanders too much when there's nothing for him to focus on, if his thoughts get too dark, if his enhanced senses are reaching for every small sound that a normal person wouldn't catch, every creak of the building, every whistle of the wind, and he can't fall asleep.

Or if it's also because of the nightmares. If when he jerks awake into darkness and silence, he panics. I'm back there, I'm trapped, I'm frozen and tortured and controlled, I'm a machine and a monster.

But when he hears the TV, the muted cheers and the sports comentator, and sees the light reflected over the living room, it ground him back into the present.

[reasonsforhope]

Sometimes you just have one of those moments where the progress we've made as a culture get thrown into stark relief. You look at something and go "Holy shit, that would never have happened when I was a kid."

Today, I had one of those moments when I realized that the teenage boys I'm working with are just. genuinely, openly enthusiastic about going to Build-a-Bear for their outing.

These are sixteen and seventeen year old boys! They just had a whole conversation about what to name their "cute", mostly new squishmallows! They're genuinely excited that they're going to Build-a-Bear this weekend and asking other kids to pick up specific accessories for them!!

Holy shit, that never would've happened when I was 16. None of the boys would have dared to be visibly interested - and neither would most of the girls! There would have been a million gay jokes and "Haha, you're a girl" jokes and "What are you, a baby?" jokes. Teenagers weren't even supposed to care about anything back then!

Less than 15 years later, and I'm watching three 17 year old boys treat all that as not even worthy of comment.

So let's call that a reason for hope. Even when the kids aren't alright, in some ways apparently they are alright. Go Gen Z, honestly. It's so lovely to watch you guys just openly doing and saying stuff that, when I was a teen, would've been a social death sentence.

[biggest-gaudiest-patronuses]

i vote that next year instead of reading Dracula we do a Jeeves & Wooster Book Club. those two never got the rabid tumblr shipping fandom they deserved (disqualified for the sheer technicality of being published a century too soon). we must correct this injustice

[bunnieswithknives]

Does anyone else other than hazel end up finding out abt dev’ prosthetic?do Winn and jasmine find out?

Eventually he does get comfortable enough to let other people see it, he still refuses to tell anyone what happened though.

[lucabyte]

i feel like people are sleeping on the occam's razor situation of how buckwild it is to outright accuse a guy of being a clone of your friend even if you DO have a lot of circumstantial evidence. there's other options is what im saying. they could just be like. a guy. that's a sensible deduction. you should explore that deduction. ignore my shirt that reads I <3 RED HERRINGS.

i still think odile has the correct theory on lock but she's smart enough to know it needs like... a real smoking gun to be able to bring it up without sounding insane.

anyway. (mirabelle voice) i know its rude to speculate but has anyone else noticed the grieving? they seem to be grieving. does anyone have any thoughts on the grieving? i have some thoughts on the grieving.

[yrsonpurpose]

TAYLOR ZAKHAR PEREZ in 2024 ❀ Everything I have now is everything I wished for five years ago, ten years ago, and I think we can get caught up in the haves and the have nots, and I wish I had this and I wish I had that. I think the wishing is cool, as long as you stay grateful.

[poorly-drawn-mdzs]

Bonus 13: Beware the Grapes of Wrath.

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[reputayswift]

New years are scary, tag this with something you’re looking forward to in 2025! 🎉🪩

[ghostboidanny]

In a dpxdc demon twins AU, I think Damian would be Pissed that Danny's ghost name is Phantom = Fenton, when he could have gone with Ghoul = al Ghul

Danny Ghoul is so much better and cooler than Phantom! Absolutely no other reason for his anger!

[deoidesign]

Doing master studies the only way I know how: Stealing them and making them my guys.

(Barberini Faun)

(The Fallen Angel - Alexandre Cabanel)

(Covent Garden - William Bruce Ellis Rankin)

[greencarnation]

eleven is fascinating to me because he came right off the back of tens horrible traumatic breakdown after he lost everything and he immediately tried to establish himself as the opposite of that. he is funny and goofy and almost childlike, and he bulldozes on in his adventures with amy like nothing happened at all. but then something happens and his masks slips and it's like oh! the core of this man is still anger. he is so so angry all of the time and this façade is the only thing stopping him from being consumed by it. he isn't over any of it and he hasn't moved on. he is wearing a fez and laughing but under that all that exists is age old anger and grief and it is going to consume him

[reasonsforhope]

A new treatment combining ReCET and semaglutide could eliminate the need for insulin in type 2 diabetes, with 86% of participants in a study no longer requiring insulin therapy. The treatment was safe and well-tolerated, and further trials are planned to confirm these results.

Groundbreaking research presented at UEG Week 2024 introduces a promising new treatment approach for type 2 diabetes (T2D) that has the potential to greatly reduce or even eliminate the need for insulin therapy.

This innovative approach, which combines a novel procedure known as ReCET (Re-Cellularization via Electroporation Therapy) with semaglutide, resulted in the elimination of insulin therapy for 86% of patients.

Globally, T2D affects 422 million people... While insulin therapy is commonly used to manage blood sugar levels in T2D patients, it can result in side effects... and further complicate diabetes management. [Note: Also very importantly it's fucking bankrupting people who need it!!] A need therefore exists for alternative treatment strategies.

Study Design and Outcomes

The first-in-human study included 14 participants aged 28 to 75 years, with body mass indices ranging from 24 to 40 kg/m². Each participant underwent the ReCET procedure under deep sedation, a treatment intended to improve the body’s sensitivity to its own insulin. Following the procedure, participants adhered to a two-week isocaloric liquid diet, after which semaglutide was gradually titrated up to 1mg/week.

Remarkably, at the 6- and 12-month follow-up, 86% of participants (12 out of 14) no longer required insulin therapy, and this success continued through the 24-month follow-up. In these cases, all patients maintained glycaemic control, with HbA1c levels remaining below 7.5%.

Tolerability and Safety

The maximum dose of semaglutide was well-tolerated by 93% of participants, one individual could not increase to the maximum dose due to nausea. All patients successfully completed the ReCET procedure, and no serious adverse effects were reported.

Dr Celine Busch, lead author of the study, commented, “These findings are very encouraging, suggesting that ReCET is a safe and feasible procedure that, when combined with semaglutide, can effectively eliminate the need for insulin therapy.”

“Unlike drug therapy, which requires daily medication adherence, ReCET is compliance-free [meaning: you don't have to take it every day], addressing the critical issue of ongoing patient adherence in the management of T2D. In addition, the treatment is disease-modifying: it improves the patient’s sensitivity to their own (endogenous) insulin, tackling the root cause of the disease, as opposed to currently available drug therapies, that are at best disease-controlling.”

Looking ahead, the researchers plan to conduct larger randomized controlled trials to further validate these findings. Dr. Busch added, “We are currently conducting the EMINENT-2 trial with the same inclusion and exclusion criteria and administration of semaglutide, but with either a sham procedure or ReCET. This study will also include mechanistic assessments to evaluate the underlying mechanism of ReCET.”

-via SciTechDaily, October 17, 2024

--

Note: If it works even half as well as suggested, this could free so many people from the burden of the ongoing ridiculous cost of insulin. Pharma companies that make insulin can go choke (hopefully).

[anewp0tat0]

Black Butler Amino, Black Arts Magazine - Holiday Party

it doesn't quite look like a holiday party from here, but what I imagined as a humble little piece is~~ Ciel and Lizzy sneak away from the big bustling midford Christmas party and raid the kitchen desserts, like they did when they were kids(it was Lizzy's idea, Ciel clearly hasn't been himself since he returned, and she wanted to bring him back).

[ferberus-skull]

you WILL look at litebrite btw

[trying-to-jew]

Constantly torn between my desire to convert and the crushing weight of knowing that I won’t be able to exist in the wider fandom spaces that I love without being constantly reminded that Jews are always guilty until proven innocent post-Oct 7.

[biggest-gaudiest-patronuses]

*tries to organize my thoughts*

*remembers i'm not in school and therefore beholden to neither heaven nor hell nor any man's grading system*

*joyously shredding & tossing all my carefully arranged 3x5 mental notecards into the air like so much beige confetti. raising my arms in victory, cheering raucously until i accidentally inhale bits of homemade confetti*

(*coughing up itty bits of paper like a cat evicting a hairball with a firm understanding of tenants' rights*) wait wat happens next