#insulin is clear

[a-whispering-echo]

im rambling in the tags oops

legit NO hate to OP here though! i think the ideas fun! my autistic ass has just been given a chance to talk about something i know a lot about and i took it and ran with it oops

cross doing testosterone injections but the mtt sees him by accident and are torn on if he’s diabetic or doing heroin because cross isn’t out and it doesn’t hit them that that’s an option crackfic. yes im writing this

[divinekangaroo]

Different horse, this one in rehab. She was sold a while back with strict diet instructions due to her appearance of insulin resistance which weren’t followed, so she got fat. Her owners worked her harder and reduced food quantity (but not changing type) thinking she was just lazy or overeating, until she hurt herself badly. Word got around (as word does in horse communities) and Mr D went and reclaimed her. She is now back to trim and walking normally but won’t race again.

The most mellow horse I have had the privilege of meeting.

[dingo-saurus]

non-exhaustive list of things i need to do as a type-1 diabetic whenever i eat in order to keep my blood sugars in a healthy range (which i need to do consistently to stay alive and not need to amputate limbs or deal with organ failure later in life):

count the carbs and sugars for everything i am eating or drinking in that moment. this is obviously harder if the meal is homecooked as you need to not only work out the carbs for everything in the meal but also how much your portion would be. fortunately and unfortunately there are a number of apps that can help with this built primarily for dieting that you can take advantage of

am i taking metformin (med that reduces insulin resistance) or not? if so, normal dose. if not, slightly higher. usually only by 1 or 2 units but this varies

test my current blood glucose. even if i am wearing a glucose monitor i need to do this manually with a fingerprick test to confirm the monitor is correct (they often aren't). is it in range? normal dose. too high? a little more, depending on how much higher my blood glucose is and how much my body personally needs to correct sugars. which needs to be worked out with testing, and is subject to change. too low? have a few sips of sprite or some jelly beans while meal prepping. how much i need to bring it up into range is subject to change and something that experience with my body helps me with

okay so now we need to figure out how much insulin i need with the meal, taking all the above into account. there is a mathematical formula that helps to determine this based on your weight that i was taught by a medical professional and type 1 diabetes expert (yes the advice is different between type 1 and 2. you need someone who knows your specific type or you will get Bad Advice). this is not infallible, in fact it does not work for me at all (i sometimes need about twice the insulin i should need, due to my body's fluctuating insulin resistance). so i have had to deviate from it and work things out for myself, increasing the ratio of insulin-to-carbs until i was getting it correct. this can change based on basically Anything. have i been exerting myself today? are the specific carbs in the meal quick or slow to release? is there protein? am i sick? do i have a migraine/have recently had a migraine? did i sleep well? am i stressed about something? did i take a dose of basal insulin today (and how much)? experience will help me feel this out. i can still get it wrong even after 4 years, and need to correct it after the meal

okay, i've done the calculation and have my number. when do i give myself the insulin dose? well that depends. i need to time it so that the peak of the insulin's effectiveness hits when the meal is hitting my blood sugars. i have a couple of rapid-acting insulin brands that hit at different times, but the one i'm taking rn takes about 30 minutes. so either before or during the prep/cook time i need to duck out and do my dose, or i need to wait for a time after i take my dose to grab whatever i'm grabbing. i set an alarm for this

inject insulin (thankfully this was not difficult for me to get used to as it's MUCH easier these days than it was in the past)

eat

you are doing this 3 times a day, more if u want to snack. my body changes constantly, and requires frequent rethinking of all of the above (metformin is making this easier for me, thankfully. i had to troubleshoot and figure this out myself after 3 frustrating years)

as you can imagine, it generally means i do not eat out (most restaurants do not keep track of the carbs and sugars in their meals) and cannot eat homecooked meals unless the cook is willing to calculate exactly how many carbs and sugars are in the meal so i can figure out how much is in my serve

it takes a lot of energy, attentiveness, adaptability, determination, and perseverance to treat your diabetes effectively day-to-day and avoid damaging your body or putting your life at risk. thankfully i have the support to do that monetarily, medically, and socially. not everyone does

be kind to diabetics

[timeisacephalopod]

When American politicians discuss doing universal healthcare in their country and start whining about the possibility of "medical tourism" where people would theoretically go to America to get healthcare I want to scream and shake them. That already exists- Canada is where Americans went to get their fucking insulin because their own government failed them so hard another country nearly had an insulin shortage a few times over the course of the pandemic alone.

If you want to talk about medical tourism and that """"straining""""" the American healthcare system then maybe take a look at the way Americans are consistently causing strains to Canada's healthcare!! And I assume Americans don't just travel here for healthcare either, so when American politicians act like they're Just The Best and everyone will go to America for healthcare I want to be like THE ISSUE YOURE BITCHING ABOUT EXISTS AND ITS NOT HAPPENING TO YOU ITS HAPPENING TO CANADA AND ITS BECAUSE YOU REFUSE TO ADEQUATELY SERVICE YOUR POPULATION AND MORE THAN ONCE CANADIAN DIABETICS WERE THE ONES WHO'D SUFFER FOR IT. Like you want to talk medical tourism without ever acknowledging your population using other countries healthcare, which I guess is fine because it's not America footing the bill, really?

[taffybuns]

if anyone has money to spare for donations, im forwarding more links for palestinian aid

CareforGaza is a nonprofit that provides direct aid to Palestine, and you can donate directly here

Operation Olive Branch is a document that lists evacuating families that need assistance, which gives information on the families, the urgency, and tracks the progress of their fundraisers

eSims for Gaza lists very clear instructions on how to purchase e-sims to keep them connected, they are urgently in demand

Here is a project that distributes feminine hygiene kits directly to Gaza

Mutual Aid Diabetes has channels set up for you to donate insulin and medication to diabetics in Gaza, as well as lists fundraisers for diabetics seeking to evacuate

please keep sharing and adding links on this site, please add more if i'd missed any, and please don't stop talking about Palestine.

[periwinklecosma]

list of palestinian fundraisers (part 1)

(part 2) (part 3) (part 4) (part 5)

during the past several days, i have received a mass influx of asks and messages from vetted palestinians seeking my support for their campaigns. up until now, i have been answering these people on an individual basis, but i no longer find that very practical given how many there are, so i'm going to try to create masterlists like this one instead. it's something i had been considering doing for a while now, since i find that lists tend to get more engagement, not to mention that it's recently become clear that a good handful of people on here baselessly equate asks with scams, so maybe this will help.

if you see this post, please consider not just reblogging. the point of lists like these is to spotlight various fundraisers and get people to support them monetarily. please, try picking out one of two of these and consider contributing! every little bit helps!

Ehab Ayyad (@ehabayyad23) - €1,055/€50,000 (2.11%) // new fundraiser not yet vetted but appears legitimate // EXTREMELY LOW ON FUNDS

Basel Ayyad (@basel-1995) - CHF6,978/CHF60,000 (11.63%) // vetted twice by @/el-shab-hussein and @/nabulsi (#214 on this spreadsheet) -> Note: Basel's daughter is chronically ill and requires medical care.

Safaa and Abed (@safaabed8) - €27,379/€90,000 (30.42%) // vetted by @/90-ghost (here) and @/northgazaupdates (here)

Adham Ayyad (@stupendouswolfearthquake) - kr10,698/kr750,000 (1.43%) // vetted by @/90-ghost (here) // EXTREMELY LOW ON FUNDS

Hadeel Mikki (@hadeelmekki) - €12,817/€35,000 (36.62%) // vetted by @/90-ghost (here)

Walaa Ahmed (@ahmed79ss) - $10,631 CAD/$50,000 (21.26%) // vetted by @/90-ghost (here) -> Note: Walaa has Type 1 diabetes and is in desperate need of insulin.

Mahmoud Alkhaldi (@mahmoud1995) - $10,651/$50,000 (21.30%) // vetted by @/90-ghost (here)

Abdel Muti Al-Habil (@abdelmutei) - €9,648/€25,000 (38.59%) // vetted by @/90-ghost (here)

Nour Alanqar (@noor-alanqar) - €19,603/€40,000 (49.01%) // vetted by @/90-ghost (here)

Heba Al-Anqar (@heba-baker) - €3,504/€60,000 (5.84%) // vetted by @/90-ghost (here) // LOW ON FUNDS -> Note: Heba's father is physically disabled with heart problems, and Heba's mother suffers from asthma.

[ms-demeanor]

I've been following what's been going on with Belphie the kitten and his person, Greer Stothers, has just mentioned pet insurance in a tag on a post and I wanted to give an example from my life backing up why pet insurance can be a good idea and why I think it is worthwhile.

Two years ago my sister's dog had bloat while she was on vacation. The kennel he was staying at recognized symptoms and called my sister to clear them to take him to the emergency vet. My sister is very financially secure and this dog is an enormous part of her life, so she said yes with barely a moment of hesitation. That ended up being about twelve thousand dollars of emergency surgery.

Large Bastard and I got pet insurance for Tiny Bastard the same week because we realized that if someone had presented that option to us, we would have had no choice but to have Tiny Bastard put down, and we didn't want to be put in that position.

I did a lot of research about different kinds of pet insurance and different levels of coverage and annual maximums and deductibles and so on and so forth. Tiny Bastard is a senior dog, so this was going to be expensive no matter what options we went with, so I chose a moderately priced plan with a $500 annual deductible, unlimited annual coverage, that pays 80% of the bills incurred annually below the maximum. What that means is that we pay the first $500 of care totally out of pocket, after which point we are reimbursed 80% of any vet bills for care covered by the plan.

The first year we had this plan I was kind of iffy about it. It's a noticeable monthly expense and we didn't even spend the deductible in vet bills the first year. Except that a month before the policy was set to renew, Tiny Bastard got diagnosed with diabetes. We now have monthly insulin costs and syringe costs; there are tests she has to have regularly to monitor her overall condition and we need to do more frequent vet visits to track symptoms.

Suddenly the insulin alone means that the insurance is break-even within six months and the additional visits and tests are something we can afford instead of something we'd have to put on credit.

Our plan (through ManyPets) covers medication, surgery, diagnostics, medical equipment, and euthanasia and cremation. It doesn't cover pre-existing conditions, joint conditions for dogs who were signed up over a certain age, dental care, spay/neuter, vaccinations, or prescription food but honestly all of that makes me just kind of wish we'd signed her up earlier - her knee problems *would* be covered if we'd had her signed up as a puppy, and the monthly cost would have been lower if we'd signed her up then. And there are at least a few emergency vet bills that I wouldn't still be paying off on my credit card. Hell, I've probably paid more in interest on some bruising she got in a fight three years ago than I have for this policy as a whole.

I am glad that Greer is able to take care of Belphie. I am glad that my sister was able to take care of her dog. But I'm also really, really glad that for a relatively low cost, I would be able to take care of Tiny Bastard if she were catastrophically injured, or if she needed emergency surgery. I'm glad that I'm able to take care of her now with her medications and her additional vet visits.

There are a lot of people who say that pet insurance isn't worth it, especially not for young animals. But if your young animal gets very sick, or gets badly injured, or eats a hairband and needs an emergency endoscopy, then it will probably be VERY worth it. It's a risk/reward question. You feel like you're wasting money if you're paying for a policy that you never use, but honestly that just means you're lucky to have a healthy pet.

I'm lucky that Tiny Bastard was relatively healthy before I got the insurance; I'm also lucky that she was insured when she was diagnosed with a chronic illness that will need lifelong care. This enables me to provide care for her that would otherwise be financially unmanageable, and that makes the insurance *extremely worth it* from my perspective.

And Belphie is a good example of why it's a good idea to get coverage even for very young pets. Greer is recommending it because this kitten has required a tremendous amount of care during a period in his life when it's generally taken for granted that a cat will be healthy. (And Greer is not stupid for forgoing pet insurance - pet insurance is still a relatively new concept and there are lots of people who are leery of it for a number of good reasons)

So I'd say that if you've got a pet or are getting a pet it is very worthwhile to find a pet insurance plan that fits in your budget. There are a variety of plans out there and some are very inexpensive. Check coverage levels (you can even get some with wellness plans that include dental care and vaccinations) and see if there's something that works for you.

I personally don't think I'm ever going to own another pet without having pet insurance. It's ridiculous how much easier it is for me to say yes to diagnostic tests or different treatments than it was before because I know I'm going to be able to fit Tiny Bastard's care into our budget.

[yandere-daydreams]

Title: In Which Gojo Satoru Commits Regicide.

Pairing: Gojo Satoru x Reader (JJK).

Word Count: 0.7k.

TW: Mentions of Consensual Sex and Off-Screen Violence. I Am Coping, But I Am Also Pissed. Be Patient, I Beg of You.

Live Dove: Tender and Sweet.

You’d been a little confused when Satoru came home uncharacteristically giddy in spite of the bitingly cold February weather, and a little more than confused when he said he had something to show you, took you by the arm, and teleported you out of your apartment entirely (after waiting for you to give your clear and enthusiastic consent, of course). You had no idea where he was taking you, but it only took a single second of whipping your head in either direction, a single glimpse of those awful bright yellow curtains and tacky eagle rug, to know where you were.

“Satoru,” you gasped, and his grin widened. “Is this the oval office?”

“The one and only.” His voice was low and smug, his tone more than enough to prove that he already knew you like your surprise. Wrapping an arm around your waist, he swept the content the presidential desk in the floor with his free hand and lifted you onto its outer edge, placing himself in the space between your open legs as if brought there by a gravitational pull. You draped your arms around his neck, pulling him into a long, deep kiss as sweet as apple pie, or funnel cake, or other true symbols of American culture that were formed through a broad, grassroot endearment rather than a bunch of gross old men deciding they’d look cool on a flag three-hundred years ago.

Reminded of gross old men, you pulled away with another sharp gasp. “But, ‘toru, what if he catches us?”

You had no problem with getting your back blown out by your loving boyfriend in one of the most sacred rooms in the United States, but if that lead-paint poisoned geezer happened to walk in (if he even could walk on his own, anymore), it’d totally ruin the mood. Satoru only laughed. “Don’t worry, baby,” And then, flashing you a quick wink, “I made sure to clear the place out for us.”

“Satoru, you didn’t!”

“Guess some fascists just can’t handle their blunt force damage,” he said, shrugging. Suddenly, your expression dropped, and Satoru noticed right away. “What’s wrong, baby?”

“Well, it’s not that the racist, senile felon didn’t deserve to have his skull caved in by a bisexual transgender man – since, y’know, we’re both bisexual and transgender.” Satoru nodded, affirming the fact that you two were similarly transgender and also bisexual, which you were. “It’s just – now that misogynistic white supremacist who jerks off to Margaret Atwood’s The Handmaid’s Tale every night before fucking his couch is going to be president, and that that kind of sucks too.”

“James David Vance?”  Satoru asked, refusing to use his initially and therefore highlighting how stupidly pretentious his name was. “You think too little of me, sweetheart.”

Possibly for the third time, you gasped. “Is he…?”

“Mhm. Took care of him right before I came home, got him right as he was coming out of his filler appointment. Beat him to death with a copy of his own book and everything, after leaving it a one-star review on Goodreads, of course.” Again, he shrugged, but smile gave away his self-satisfaction. “It’s all in a day’s work for the world’s strongest and most politically active sorcerer, I guess.”

“But, if that pathetic old man and his castrated lapdog are both dead, then who’s the president?”

“Check the news, baby.”

You fished your phone out of your pocket as Satoru sucked hickeys into your neck, obviously waiting until he had your full attention to go further. Again, you gasped. You were starting to lose count of how many times that’d happened, so far. “Abortions and insulin are provided upon request and also free now?!”

“Oh, wait, are they?” You turned your screen in his direction, and Satoru hummed in approval. Everyone’s quality of life had gotten a lot better since your good friend, Nanami Kento, was placed onto the Supreme Court in the final days of Biden’s term. “Sick. Not what I was talking about, though – scroll down.”

You scrolled down, and gasped once more. Your throat was starting to hurt. “Everyone in the country’s unanimously ellected the first female president?”

“Not just any female president,” he said, smirking and tapping on a trust-worthy article from a reliable and non-partisan source. “Say her name for me, baby.”

The final gasp you gaspt was the loudest and most gasp-like of all.

“Hatsune Miku?!”

[thebibliosphere]

Are you familiar with any connection between mast cell issues and type 1 diabetes? I have a family member who developed and got diagnosed with diabetes when he was a kid, and his mother is convinced it was because of his childhood vaccines. Now i'm aware enough that vaccines could cause an immune system reaction like what you were talking about about before, with people who are predisposed to certain conditions that could suddenly self destruct when something like vaccines or a cold just tips the condition over. Unfortunately his mother went full anti-vax after this happened :/ anyways your post made me wonder if there was a connection between diabetes 1 and mast cells

Oh, hey I actually read something about this recently:

Tl;dr:

Mast cells are highly differentiated, widely distributed cells of the innate immune system.

The involvement of mast cells in diabetes is corroborated by findings indicating that these cells are associated with inflamed adipose tissue, the development of certain diabetes complications such as diabetic nephropathy, and reduced wound healing in the case of diabetic foot lesions [70,71,72,73].

In the present review we have discussed the role of mast cells in the diabetic pancreas. Their increased presence in the pancreas of human subjects with type 1 diabetes raises the possibility that these cells could be implicated in the pathophysiology of this form of diabetes, which is due to autoimmune destruction of the insulin-secreting beta cells.

However, it is not clear if and why mast cells could be dangerous or protective in this regard. More studies are needed to determine whether and how manipulation of these cells might impact on the natural history of type 1 diabetes, which could allow the development of a strategic approach targeted to modulate mast cell function

- - -

Basically, damned if we know, but they’re studying it.

As for whether a vaccine caused him to develop type 1 diabetes, personally, my money is on no. It’s primarily (though not always) a genetic autoimmune disorder that’s waiting to go off. The vaccines might have caused an inflammatory response that drew awareness to existing symptoms that resulted in diagnosis, but the pre-disposition was likely always there.

Viruses on the other hand can promote autoimmunity, (though there’s some debate about whether or not the link between viruses and the development of diabetes type 1 is valid. More research is needed) so that’s an even more important reason to vaccinate imo.

Like fuck messing with that. You get rubella AND an autoimmune disease potentially triggering early because of it? Fuck that.

[wlwsoccerfics]

Unexpected(LucyBronzeXKeiraWalshXTeenReader)

AN: i thought i mentioned it ,but wonze are Not together in this.

Warnings:mentions of underage drinking, Type 1 diabtes.

Summary:you go to England Camp with your Mom and your Mama is really confused on why you are there. Well everything is not what it seems.

You walked into the hotel lobby, right behind Lucy. To say Keira was confused to see you there was an understatement. "Love Bug? What are you doing here?" She asked and hugged you. You hugged her back.

You glance over to your Mom.

"hi mama, well mom is being..." You started ,but was interrupted by Lucy.

"you better choose your next words very carefully, y/n Madita Walsh-Bronze! You are on thin ice already!" She told you. It was clear she was not happy with your behavior.

Keira still was very confused. "Can one of you please tell me what happened?" She asked.

"well your daughter came home yesterday smelling like an entire bar! Like she took a bath in booze!" Lucy explained the Situation to Keira.

"y/n! You are 15! You are way too young to drink and Not to mention it can mess with your diabtes! Your mom has every right to be upset! Have you talked punishment already?" Keira wanted to know.

You sigh and Cross your arms over your chest.

"punishment? Mama you can't be serious?!" You replied, biting down on your bottom lip.

"i take that as a no!" Keira said and looked over to Lucy.

Lucys eyes wander to you again.

"i think she is grounded for the next few days and can only go outside with us and can practice with us! No Walking around on her own! Just to get food." Lucy suggested.

"yes ,seems fair!" Keira agreed. You look at your moms and nodded your head. You could always rebel against it later.

Beth came over as well. Dragging hers and Viv's daughter Mattea behind her.

"Look it's your cellmate!" Beth told Mattea, pointing at you.

"was she at that Party as well?" Lucy asked, sighing softly. She had heard from a few parents about this afterwards , cause alot of the Kids came home smelling like booze.

"yes! Mattea came home drunk! she is gonna stay in her room cause she is grounded and the only free bed left is with Y/n!" The blonde explained.

"you two can study together! That's great!" Keira answered.

You and Mattea glance at one another. Everything is going according to plan!

You and Mattea knew one another very well. Of course you did. You grew up together. Because of your parents & because of the friends you share. But you also secretly have been together for 4 months now.

Keira, Lucy & Beth are in the gaming room with the rest of the team while you and Mattea were alone in your shared room. Your parents were tracking your phone so they would know when you leave the Hotel room. You couldn't exactly leave it behind cause your Insulin pump was connected to it. That was their safety net. But it wasn't exactly like you planned on leaving anyways.

In fact you and Mattea had planned getting in trouble for drinking. Which you didn't actually do. You just made sure your clothes smelled like booze and had one sip of Vodka and a sip of Beer so your breath would smell like it as well. Your girlfriend did the same. Cause hello free Hotel room with your girlfriend. The two of you knew that if you stayed at home your relatives would have watched over you and there would be no way the two of you would get some alone time. Cause your relatives tended to worry alot about you because of the diabtes. But here you are at the Hotel , you had your own room with Mattea and the Chance to practice with Englands Elite. Which included your moms.

"i can't believe it actually worked out for us! That plan was brilliant!" Mattea replied, cuddled up in your arms.

You held her close. Smiling softly.

"indeed it was! I am so happy we get to see one another and get to spend so much time together!" You answer. Kissing her forehead.

You were listening to a new Podcast for a bit before Mattea ended up falling asleep. You stroked her hair gently while continuing to listen to the rest of the Podcast. This went on for a while.

Later that day the two of you went to dinner with the Team. "So question? Why did i hear that my nieces have been drinking?" Leah asked you and Mattea. Yes you see Leah as an aunt cause she has always been really close with Your Mama and Beth. You rubbed the back of your neck.

"uh you probably heard it cause our parents couldn't keep their mouths shut!" You replied half jokingly. You Mom shoot you a warning look.

"y/n Madita Walsh-Bronze, this isn't a joke." Lucy answered. There was the full name again. You still were on thin ice.

You let out a soft sigh.

"i am sorry! What i meant is that i made a mistake!" You answered.

"we all have been there ,kiddo!" Leah admitted.

"so true!" Georgia nodded her head softly.

"i am sorry as well! Won't happen again!" Mattea said as well.

"i hope that's true!" Beth replied, looking at Mattea and then over to you.

"okay let's put that behind us! right now i just want to know how your blood sugar is doing." Keira asked. Your Mama always tended to ask that before meals. You blushed a bit, slightly embarrassed about your Mama asking.

"Mama, it's fine! You don't always have to ask." You told her. Mattea almost swooned cause you looked so adorable blushing. But she managed to lay low.

"i do have to. You are my child! I worry! It's my right!" Keira stated. You were Keiras Baby still. Didn't matter that you were a Teen. You would always be her baby. No matter how old you are. It's probably how all moms are with their Kids. Well most of them you were quite sure about that.

"blood sugar is perfect right now." You showed her your phone, so she could see the numbers herself. After some more talks with the rest of the team you went back to the Hotel.

Back at the Hotel you hugged both of your moms 'goodnight' and went back to your room with Mattea. After a quick shower you put on an old England Hoodie which used to be your moms. With that you put on some black shorts. Then you crawled into bed. Waiting for Mattea to finish her shower. But you were so tried that you couldn't keep your eyes open anymore so you fell asleep before she returned. The two of you cuddled all night. Sleeping peacefully.

In the morning the two of you got ready for breakfast, when you reached the breakfast buffet only a few other people from the Team were there. Including your Mom.

"morning kiddo, hey mattea. How did you two sleep?" She asked and kissed your head. Sitting down at the table with you and Mattea.

"morning Mom. I slept great. How about you?" You answered, smiling a little.

"i slept good too." Mattea replied.

"so did i!" Lucy said, also smiling a little.

The three of you talked a little about the next few days and about the fact that Lucy wasn't Happy with you drinking. You were debating whether to tell her that it was all a plan ,because you didn't like how your mom was struggling to deal with the fact that you are at the Teenage age where you try out new things. Soon you were joined by Lessi, Ella & Leah at the table.

"so either of you got a girlfriend?" Ella asked you and Mattea. It was no secret that you both were lesbians. When Ella asked the question you almost choked on your Tea. After coughing a bit.

"nope. Very single!" You told her. Mattea and you quickly glancing at one another.

"yes me too!" Mattea replied. Alessia & Ella looked at eachother. That look made you think that they might knew the truth. Your mom and Leah didn't seem to notice though.

Your mom told you to meet them on the pitch in an hour for Training. So you went back to your room to get ready. Mattea sat on the bed, putting on her socks.

"do you think, Lessi & Tooney know we are together?" Mattea wanted to know. You put on one of your Training Kits.

"it sure is possible. but i don't think they gonna tell on us!" You told your girlfriend. Kissing her forehead gently.

A little while later you and Mattea were on the pitch practicing with the team. Sarina was watching the two of you closely. She has seen the two of you play before. Given that you just made your debut to Play for the Chelsea Senior Team ,while Mattea had her Senior Debut for Arsenal. But she was so impressed with both of you that she ended up talking to your parents and to Beth. Pulling you Guys aside after practice.

"Girls, i talked with your moms! I want both of you to become lionesses!" Sarina replied, smiling at the two of you. " You both are really talented." She added on. Both you and Mattea stared at eachother in shock before she jumps into your Arms and you hug her.

"i can't believe we are so lucky, Babe!" Mattea happily said.

"thank you Sarina!" You told her and held your girlfriend close.

"yes thank you!" Mattea answered.

Neither of the two realized yet that your secret was out.

"did you just call her Babe?! Oh my god. I knew something was up!" Beth said and you blushed a little.

"oops..." You replied and started blushing as well.

"you two have some explaining to do!" Lucy stated.

"that's my Queue to leave!" Sarina quickly replied and walked away, she couldn't help but smile a little.

You ended up explaining everything. Including that you didn't actually drink and how you planned the whole drinking thing. Knowing there was no way you two would be allowed to stay home if you got drunk and the only solution was to take you guys to Camp with them. By the end of the explaination your moms and Beth looked impressed but also a little shocked.

"the two of you Scream trouble!" Lucy answered and laughed softly.

Beth nodded her head in agreement and grinned.

"but it's cute how much effort you put into this just to be together!" She replied.

"we all hopefully agree that now that we know you are a couple ,there need to be changes made in the rooming arrangement." Keira told you.

"but Mama that is not fair!" You let her know that you are not happy about it. There was a discussion about it and when the team heard about the Situation, Alessia offered to room with you and Ella was sharing a room with Mattea. That was something you sure could live with because you thought Alessia was quite cool. Besides you just managed to officially become Part of the lionesses. So you didn't really had much to complain about.

[mangocheesecakes]

the scammer @/rescueplease has now been deleted, but since a lot of people are still reblogging my posts about it, i'm changing my pinned post to a list of currently active scam accounts

scammers with the same m.o., sometimes similar profile pics and linktrees/paypal addresses:

> numberonegoateeeagle (paypal name 'Jeff Owino') new

> nour-samr (paypal name 'Nour Samar') >> nour-samr0 new/remake

scammer pretending to be a sick Black person, using the paypal name, 'Alafred Opondo'

> enchantingqueencreator

the 'insulin scammer''s latest blog (at least i think it's their latest blog:

> fancycoffeepeanut

empty blogs who are mass-reblogging the scam posts and are likely just the scammers sock puppet accounts used to pad the notes of their posts, pls block them too:

> chopra-79

> futuristicphilosopherartisan new

deleted/deactivated/changed url:

maina-3

immariaanszz >> iammarinassaa >> iammarinassaass

jovialsuitdonutai (paypal name 'jeff owino')

khalilhan (paypal name 'samuel obiya') >> khaliilhan

marylinfwaznassar (paypal name 'maryline lucy')

stickytreephilosopher (paypal name 'jeff owino')

perfectlyminiatureface (paypal name 'jeff owino')

optimisticalpacalady (paypal 'jeff owino')

omarkhalini (paypal 'fred odhiambo')

marylinefwaznassar (paypal 'maryline lucy')

khalilhani (paypal 'samuel obiya')

weepingpersondestiny (paypal 'jeff owino')

as always, please block and report these blogs, and more importantly, warn your friends, mutuals, and followers if you see them reblogging their scam posts. if you see a donation post/blog that you believe may be a scam, please do look their url up first on the tumblr search bar to see if someone has already called them out. i will try to update this post with the scammers' new accounts/url as we discover them. please also go to @kyra45's blog, as they are faster and more thorough in updating about newly discovered scams.

some red flags to look out for before sharing donation posts/donating:

new blog, or a couple years old but has only a few random, sporadic posts

backdated posts

spamming asks to a lot of other users, even the ones they don't know or have just followed, and even when the user has made it clear they don't want to receive requests to boost dono posts

is asking you to answer their asks privately, or is sending you a message directly

is straight up asking you for money, and usually for impossibly large amounts

do not put their paypal/money transfer links on their post itself, usually claiming it's to protect their 'privacy'

is using Zelle for their money transfer account, especially if the person is claiming to be in Palestine

please don't be so quick to entertain donation requests and to give away your money, especially if the user ticks a lot of these boxes. if you are familiar with the place they say they are from or the language they are supposed to speak, try conversing with them for a bit to see if their claims would hold. you can also browse my 'donation scam' tag or kyra45's blog to compare if the user has any similarities with past scammers that we've discovered.

that's it po. let's all try our best to look out for each other and make sure that our resources are going to the actual people in need, especially in the case of Palestinians asking for help. the last thing they need right now is for shitty lowlifes to use their suffering to make a profit.

[itsa-me-lily]

I am still tired, but brain is less mush after some lunch. (Can you guess what I had)

Here is other Simon & Thimble playlist

Here is more Military Program Spouse AU

It helps to assume here that unless stated otherwise Simon is wearing a medical mask around reader. She’s just like whatever floats your boat my dude

Content warning;

Mention of food, medical devices, scars, cellulite

“Simon whatever your middle name is Riley you better not be looking at my legs.”

Maybe his mum had a point, that women developed eyes in the back of their head. He wasn’t deliberately looking at your legs, but he wasn’t not not looking either. For some reason unbeknownst to him, you had decided that you had to make the biggest batch of soup known to man. Sure the seasons were changing, summer slowly letting go for fall, but it wasn’t as if a chilly wind was rattling at the windows threatening to steal whatever heat existed. It was still relatively balmy, warm enough to have the windows open and enjoy the breeze. Warm enough that having the stove going made the kitchen borderline stuffy, encouraging you to cook in just a loose tank top and shorts that hit mid thigh.

Simon wasn’t a prude, he wasn’t scandalized at seeing the curve of your thighs, or grossed out by the cellulite. Everyone had fucking skin and however you wanted to dress in the comfort of your home you were welcomed to it. But he had eyes and well he was curious. His own body was covered in scars and tattoos that told a myriad of stories. So he looked to see what yours had to say.

Picking at the chicken you had left on the counter he counted the spots that your insulin pods left behind like stars, noticed how you missed a small strip of hair when you were shaving, even the mole that you had on the back of one ankle; they all came together to make up parts of a story about his wife that he was just starting to get.

He was so lost in thought, mechanically putting piece after piece of poached bird into his mouth, barely paying attention to anything besides the action of seeming busy, that he didn’t notice when you turned around, the exasperation in your voice finally catching his attention.

“Seriously? What did I just say?”

Simon wasn’t someone who startled, didn’t jump or hunch his shoulders to his ears. He had spent far to much time sharpening himself as to cut anyone who tried to catch him unaware. He just wasn’t prepared for you to admonish him like that, hands on your hips and looking for him to answer your question.

“What? You said not to look at your legs…I wasn’t lookin’ at them”

Not a lie, but not quite the truth.

“Yeah instead you’re eating your way through them!”

He blinked at you slowly once and then twice, following your gaze down to the plate of chicken leg quarters he was indeed making his way through. At least one looked like it had been pounced on by scavengers.

“You said no lookin’, nothing about no tasting.”

That was most certainly a twitch to your eye. That probably should have been concerning, but honestly Simon was secure enough in his height and size that if you tried to suffocate him he could throw you off. He was a good head taller than you, honestly how much damage could you do? When you pointed your wooden spoon threateningly at his chest it didn’t do much besides remind him of a little old grandma who would wield the same utensil as a weapon.

“You sir, are an asshole. Now go run to a shop and get me one of the pre cooked chickens.”

“And why would I do that?”

“Because you’ve eaten half my damn chicken and like hell is my sancocho going to suffer for it.”

“Your what now?”

Yes Simon Riley knew he was being as ass. Yes he also thought that there was a realm of possibility that your upset face and clear murderous intentions were slightly endearing. But only slightly.

“My god damn soup. I swear to god if you fuck this up for me I will find a way to make you suffer the consequences.”

“Alright alright, no need to have a bird over some-heh, bird.”

He didn’t stay to see the double middle fingers you aimed for his back, he didn’t need to. He was pretty sure you were also cursing his name and maker. It wasn’t until the front door shut behind him that your colorful vocabulary was loudly shared with the world. It made him chuckle as he picked up his pace.

Heaven help anyone who got between a woman and her soup.

Edit

I am very passionate about my soup

[lets-try-some-writing]

Sneezes and hiccups are super cute BUT i love the angst of the bots reacting to more serious medical issues. Rafael has to keep a nebulizer at the base, maybe Jack has to give himself insulin injections. God forbid Miko is stung by a wasp and starts to swell up. Humans just got so much going on Magnus in particular doesn't understand how we aren't extinct.

The team would take any medical condition VERY seriously. Squishies are already so fragile. Ultra Magnus is indeed absolutely befuddled when it comes to humanity somehow managing to drag itself away from extinction.

Ratchet would personally tend to Rafael nebulizer. He would learn how to care for it, how to make something similar in a pinch, and probably throw himself into understanding raspatory issues as a whole. One can never be too careful. Bumblebee would also probably begin carrying around an inhaler just in case. The rest of the team would go through a rundown from June in order to help if Rafael needs assistance.

Jack's injections scared the every living daylights of the team originally. To them it looked a great deal like Ratchet's attempt at playing with chemicals over the vorns. However once his issues become clear, the team would largely accept the situation and move on to helping. Ratchet keeps a small store of insulin near his work station. Arcee has been dutifully instructed in the art of giving clean injections. The rest of the bots, being too big to help with such small objects, were given a crash course in how to get to the nearest hospital in record time if need be.

As for Miko? Well let's just say Wheeljack and Bulkhead were absolutely certain she was about to explode until she reached for her epipen. Watching her swell up like some sort of balloon haunted the team for a while and they made sure to begin storing a pen in their alt modes, just to be safe. Smokescreen had to go purge after Miko's first run in with a wasp. Fleshies shifting like that isn't normal and it has haunted his dreams ever since.

Ultra Magnus will never not be confused.

[scientia-rex]

I've been trying to figure out what the deal is with prediabetes so I can write a meaningful response to an ask I got about it, and I just keep going wait--okay--here's one paper--but here's another one--here's a Cochrane review--but here's a different meta-analysis--and here's newer data from an RCT...

It's nuts! It's bananas. And anybody who says we have good, crisp, clear guidelines around what prediabetes even IS, much less what to do about it, is FULL OF SHIT.

What I really need to know in order to feel more confident about my handle on whether to medicate pre-diabetes is the population incidence. Not prevalence. Because if I take the most optimistic studies about medication as an intervention, specifically, I could be looking at about a 30-40% reduction in risk of progression to diabetes. But! How many people is that, actually? Because medication is not without its harms! We need to compare number needed to treat with number needed to harm, we need to have high-quality evidence that says yes, if we give this medication to everyone who meets X level of criteria for pre-diabetes (it's different in different sources AND it's changed repeatedly over our lifetime!), we will see a level of benefit sufficient to justify making these other people who would not have progressed to diabetes without it endure the hassle and side effects of taking a medication for the rest of their lives.

AND HERE'S THE REAL FUN PART: we don't really know where tissue damage begins! We thought we did! 6.5-7ish A1c. But it turns out there is a marked risk of retinopathy beginning at 5.5! Which is considered normal. AND ALSO we should probably be thinking of it as at least three separate disease based on our current ability to measure--A1c is a broad marker that collapses multiple forms of dysregulated blood sugar, and when we use more fine-grained tests, we see meaningful distinctions that probably affect preferred treatments between people who have impaired fasting glucose, people who have abnormal values on an oral glucose tolerance test, and people who have both. We should treat these groups differently because they reflect different underlying pathways: elevated fasting glucose means your liver is breaking down too much glycogen while you sleep, which is one issue, while elevated post-prandial glucose means your skeletal muscles (OR SOMETHING ELSE they're not totally sure) are behaving abnormally in response to insulin. IT'S NOT THE SAME THING and people with both impaired fasting glucose and abnormal post-prandial glucose are at higher risk of progression to diabetes/tissue damage than people with just one of those. AND WHILE WE'RE AT IT, what is diabetes? What's the best cutoff? What's the best measure? How many underlying pathophysiologies are getting collapsed into the same group????

THE MORE I LEARN ABOUT THIS THE MORE QUESTIONS I HAVE and experts are all being serenely confident while contradicting each other so I have to actually dig in the data a lot harder than I usually do. I've been meaning to do this for months, but one of the presenters this morning made a comment about the benefits of putting prediabetics on metformin that made me go "hm, do I need to start doing that?" and I've gone from my kneejerk answer being "no, we studied this and it doesn't help" to "I don't fucking know and neither does anyone else."

...as always, Cochrane is probably right.

[literaryvein-reblogs]

Writing Notes: Hypothermia

Hypothermia - A potentially fatal condition; occurs when body temperature falls below 95°F (35°C).

The danger signs include:

intense shivering;

stiffness and numbness in the arms and legs;

stumbling and clumsiness;

sleepiness, confusion, disorientation, amnesia, and irrational behavior; and

difficulty speaking.

The signs and symptoms of hypothermia follow a typical course, though the body temperatures at which they occur vary from person to person depending on age, health, and other factors.

The impact of hypothermia on the nervous system often becomes apparent quite early. Coordination, for instance, may begin to suffer as soon as body temperature reaches 95°F (35°C).

The early signs of hypothermia also include cold and pale skin and intense shivering; the latter stops between 90°F (32.2°C) and 86°F (30°C).

As body temperature continues to fall:

speech becomes slurred,

the muscles go rigid, and

the victim becomes disoriented and experiences eyesight problems.

Other harmful consequences include:

Dehydration

Liver and kidney failure

Heart rate, respiratory rate, and blood pressure rise during the first stages of hypothermia, but fall once the 90°F (32.2°C) mark is passed.

Below 86°F (30°C) most victims are comatose, and

below 82°F (27.8°C) the heart’s rhythm becomes dangerously disordered.

However, even at very low body temperatures, people can survive for several hours and be successfully revived, though they may appear to be dead.

TREATMENT

Until emergency help arrives, a victim of outdoor hypothermia should be brought to shelter and warmed by:

removing wet clothing and footwear,

drying the skin, and

wrapping him or her in warm blankets or a sleeping bag.

Gentle handling is necessary when moving the victim to avoid disturbing the heart.

Rubbing the skin or giving the victim alcohol can be harmful.

Warm drinks such as clear soup and tea are recommended for those who can swallow.

Anyone who aids a victim of hypothermia should also look for signs of frostbite and be aware that attempting to rewarm a frostbitten area of the body before emergency help arrives can be extremely dangerous. For this reason, frostbitten areas must be kept away from heat sources such as campfires and car heaters.

Rewarming is the essence of hospital treatment for hypothermia.

How rewarming proceeds depends on the body temperature.

Other considerations, such as the patient’s age or the condition of the heart, can influence treatment choices.

Different approaches are used for patients who are:

mildly hypothermic (the patient’s body temperature is 90–95°F [32.2–35°C]),

moderately hypothermic (86–90°F [30–32.2°C]), or

severely hypothermic (less than 86°F [30°C]).

Mild Hypothermia

Reversed with passive rewarming.

This technique relies on the patient’s own metabolism to rewarm the body.

Once wet clothing is removed and the skin is dried, the patient is covered with blankets and placed in a warmroom.

The goal is to raise the patient’s temperature by 0.9–3.6°F (0.5–2°C) an hour.

Moderate Hypothermia

Often treated first with active external rewarming and then with passive rewarming.

Active external rewarming - applying heat to the skin (e.g., by placing the patient in a warm bath or wrapping the patient in electric heating blankets).

Severe Hypothermia

Requires active internal rewarming, which is recommended for some cases of moderate hypothermia as well.

There are several types of active internal rewarming:

Cardiopulmonary bypass - the patient’s blood is circulated through a rewarming device and then returned to the body, is considered the best, and can raise body temperature by 1.8–3.6°F (1–2°C) every 3–5 minutes. However, many hospitals are not equipped to offer this treatment. The alternative is to:

Introduce warm oxygen or fluids into the body.

Hypothermia treatment can also include, among other things:

insulin,

antibiotics, and

fluid replacement therapy.

When the heart has stopped, both cardiopulmonary resuscitation (CPR) and rewarming are necessary. Once a patient’s condition has stabilized, he or she may need treatment for an underlying problem such as alcoholism or thyroid disease.

Source ⚜ More: Notes & References ⚜ Writing Realistic Injuries

[hellsite-proteins]

also, do you know any other fun proteins where the amino acids react with eachother to form a new chemical? like residues 65-67 in GFP cyclysing to form the chromophore?

to start, i had a bit of a hard time finding the right search terms for this question, and a lot of what i found is more focused on synthetic or enzymatic methods used in labs, rather than lists of natural examples. if anything is wrong or missing as always pls lmk! i rambled a lot so that info is going to get hidden under the cut, but here is the tl;dr of three relevant PTMs

one takeaway I had from trying to find things is just how unique GFP actually is! it has been important enough for studying biological systems that its discovery was awarded the nobel prize in 2008, and a lot of incredible chemistry went into modifying its structure to make other fluorescent proteins in different colours. this is important if you want to look at more than one thing by fluorescent microscopy, and was done by altering residues around the chromophore to influence its protonation state/pKa through the local environment.

disulphide bonds:

so many proteins: insulin. RNAse A. chymotrypsin. etc.

isopeptide bonds:

the collagen-binding domain of S. aureus Cna and probably several bacterial pili have intramolecular isopeptide bonds

Vibrio cholerae, which causes cholera, makes isopeptide bonds to cross-link actin in its host

there are more examples of isopeptide bonds on wiki

biaryl ethers:

a lot of these are not made by ribosomes, and it looks like all of them are fairly small and funky looking peptides, but i think that has to count at least a little bit. here are a couple:

patellamide A

telomestatin (the wiki page on this one is so short and as far as i could tell, we aren't even sure yet if this is made by ribosomes or not so i'm really pushing things here on what counts)

letter sequence in this ask matching protein-coding amino acids:

alsdyknwanytherfnprteinswheretheaminacidsreactwitheachthertfrmanewchemicallikeresidesinGFPcyclysingtfrmthechrmphre

protein guy analysis:

for all the time i spent on this post, the protein itself is kind of underwhelming. its a shorter one with three alpha helices and a small, two strand antiparallel beta sheet, with some loops in between. this could be a real peptide, or it could just be the confused ramblings of an algorithm trying to make shapes out of an input. the confidence score is pretty low, so as usual my bet would be on the latter option, but who knows? maybe this could stably exist in real life? dream big and all that

predicted protein structure:

the main keyword i was using was 'protein cyclization', so i'm sure i missed a lot, and most of what i found is focused more on synthetic methods, but i was still able to get some good information.

this first article here gives a nice overview of protein cyclization, and a lot of different and super neat ways it can be done. if anyone wants me to give a more detailed breakdown of this article i would be happy to, since i'm not sure how clear it is to people without much of an organic chemistry background.

this next article gives an overview of post translational modifications, and also looks like a good resource with a lot of information. there are so many different PTMs out there, so if you'd like me to discuss one in particular a little more, let me know as well.

this gave me a few specific PTMs to find examples of.

the first and most obvious is disulphide bonds, which are what you are describing, but far less unique, so i also want to give some other examples

another example is isopeptide bonds, which are formed between an amine and carboxyl group just like a regular peptide bond, except that these amine and/or carboxyl groups are part of the side chain, not the peptide backbone

and finally, i found biaryl ethers, which i had never actually heard of before, and are only made by microbes and scientists, and are interesting for pharmaceuticals

there are more examples that involve cyclization with the backbone, and other types of PTMs beyond cyclization, but i've already spent too long on this, so if you want something more specific then you have to ask for it