#including type 2 diabetes

[ingredientsonline]

9 Different Types of Magnesium and Their Benefits

[itsraining-honey]

hot opinions straight off the stove! 🥘🔥

[reasonsforhope]

A new treatment combining ReCET and semaglutide could eliminate the need for insulin in type 2 diabetes, with 86% of participants in a study no longer requiring insulin therapy. The treatment was safe and well-tolerated, and further trials are planned to confirm these results.

Groundbreaking research presented at UEG Week 2024 introduces a promising new treatment approach for type 2 diabetes (T2D) that has the potential to greatly reduce or even eliminate the need for insulin therapy.

This innovative approach, which combines a novel procedure known as ReCET (Re-Cellularization via Electroporation Therapy) with semaglutide, resulted in the elimination of insulin therapy for 86% of patients.

Globally, T2D affects 422 million people... While insulin therapy is commonly used to manage blood sugar levels in T2D patients, it can result in side effects... and further complicate diabetes management. [Note: Also very importantly it's fucking bankrupting people who need it!!] A need therefore exists for alternative treatment strategies.

Study Design and Outcomes

The first-in-human study included 14 participants aged 28 to 75 years, with body mass indices ranging from 24 to 40 kg/m². Each participant underwent the ReCET procedure under deep sedation, a treatment intended to improve the body’s sensitivity to its own insulin. Following the procedure, participants adhered to a two-week isocaloric liquid diet, after which semaglutide was gradually titrated up to 1mg/week.

Remarkably, at the 6- and 12-month follow-up, 86% of participants (12 out of 14) no longer required insulin therapy, and this success continued through the 24-month follow-up. In these cases, all patients maintained glycaemic control, with HbA1c levels remaining below 7.5%.

Tolerability and Safety

The maximum dose of semaglutide was well-tolerated by 93% of participants, one individual could not increase to the maximum dose due to nausea. All patients successfully completed the ReCET procedure, and no serious adverse effects were reported.

Dr Celine Busch, lead author of the study, commented, “These findings are very encouraging, suggesting that ReCET is a safe and feasible procedure that, when combined with semaglutide, can effectively eliminate the need for insulin therapy.”

“Unlike drug therapy, which requires daily medication adherence, ReCET is compliance-free [meaning: you don't have to take it every day], addressing the critical issue of ongoing patient adherence in the management of T2D. In addition, the treatment is disease-modifying: it improves the patient’s sensitivity to their own (endogenous) insulin, tackling the root cause of the disease, as opposed to currently available drug therapies, that are at best disease-controlling.”

Looking ahead, the researchers plan to conduct larger randomized controlled trials to further validate these findings. Dr. Busch added, “We are currently conducting the EMINENT-2 trial with the same inclusion and exclusion criteria and administration of semaglutide, but with either a sham procedure or ReCET. This study will also include mechanistic assessments to evaluate the underlying mechanism of ReCET.”

-via SciTechDaily, October 17, 2024

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Note: If it works even half as well as suggested, this could free so many people from the burden of the ongoing ridiculous cost of insulin. Pharma companies that make insulin can go choke (hopefully).

[afeelgoodblog]

The Best News of Last Month - July 2024

🏅- Talk about an Olympic comeback!

1. U.S. proposes ban on airline fees for seating parents next to kids

Parents should't have to pay a fee to sit next to their children when flying, according to the White House, which is moving to ban airlines from charging families extra to be seated together.

Under a rule proposed Thursday by the Department of Transportation, airlines would be required to seat parents and kids 13 and younger together free of charge when adjacent seating is available at booking.

2. A spinal injury killed Adriana Ruano's dream as a gymnast. She just won Guatemala's first Olympic gold medal as a shooter.

Ruano was training for the 2011 world championships in gymnastics, a qualifier for the London Olympics the following year, when she felt pain in her back. An MRI showed the then-16-year-old had six damaged vertebrae — a career-ending injury.

But on Wednesday, she came back as a shooter and won Guatemala's first Olympic gold medal.

3. Woman swept out to sea rescued after surviving 37 hours in 6.5' waves, drifted over 50 miles.

A Chinese woman who was swept out to sea while swimming at a Japanese beach was rescued 37 hours later after drifting in an inflatable swim ring more than 80 kilometers (50 miles) in the Pacific Ocean, officials said Thursday.

4. Afghan Sisters Escape The Taliban To Achieve Olympic Dreams

Sisters Yulduz and Fariba Hashimi are set to become the first female cyclists from Afghanistan to compete in the Olympics. The siblings fled their country after the Taliban seized power in 2021 and cracked down on women's rights, including banning women from participating in sports.

5. Stem cell therapy cures man with type 2 diabetes

A 59-year-old man had been suffering from diabetes for 25 years, needing more and more insulin every day to avoid slipping into a diabetic coma and was at risk of death. But then Chinese researchers cured his disease for the first time in the world. The patient received a cell transplant in 2021 and has not taken any medication since 2022.

6. Seventh person likely 'cured' of HIV, doctors announce

A 60-year-old German man is likely the seventh person to be effectively cured from HIV after receiving a stem cell transplant, doctors announced on Thursday. The man received a bone marrow transplant for his leukaemia in 2015. The procedure, which has a 10 percent risk of death, essentially replaces a person's immune system.

7. Every country has now banned the use of leaded gasoline in cars

Three and a half decades later, in 2021, Algeria became the last country to ban it. Leaded gasoline is now banned from being used in road vehicles in every country. It is a big win for the health of people around the world.

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That's it for this month :)

This newsletter will always be free. If you liked this post you can support me with a small kofi donation here:

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[fatphobiabusters]

If your activism for diabetics stops as soon as you have to include type 2 diabetics, then not only is your "activism" ableist and almost certainly fatphobic, your efforts are also useless. You will never improve how society treats diabetic people if you only care about the diabetic people who are viewed more favorably in this fatphobic, ableist, and dieting-obsessed world.

-Mod Worthy

[dandelionsresilience]

Good News - July 8-14

Like these weekly compilations? Tip me at $Kaybarr1735! And if you tip me and give me a way to contact you, at the end of the month I'll send you a link to all of the articles I found but didn't use each week!

1. Zoo welcomes birth of four endangered horse foals

“[The Marwell Zoo in GB] said it was "delighted" to welcome the arrivals to the endangered Przewalski’s horse herd. All four are female and said to be "doing well" after two were born in May and two in June. […] “These horses, that were previously listed extinct in the wild, are an example of how zoo breeding programmes can help restore threatened species around the world.” […] All the Przewalski’s horses alive today are descended from just 12 individuals. Current estimates suggest there are 178 mature individuals living in the wild.”

2. Restoring woodlands and planting trees for sustainability success

“In 2023, [the Marwell Zoo] planted 9,000 new trees […] both within the zoo and on our surrounding land. […] Marwell tries to encourage natural feeding behaviour and nutrition by including leafy material [in animals’ feed] as much as possible. […] Planting more trees and enhancing management of our existing woodlands, prepares the way to further self-sufficiency in browse production in the future. Plus, it creates new habitats for wildlife in our woodland areas.”

3. Inclusive Playgrounds Allow Children Of All Abilities To Play

“With ramps allowing children in wheelchairs to ascend the central play structure, as well as numerous other swings and apparatus usable for children of all abilities, the 16,000-square-foot P.K.’s Place is St. Paul’s first fully inclusive playground. […] To be universally accessible, a play area must have at least 70% of its play features fully accessible, far more than required by the Americans with Disabilities Act (ADA). […] Play areas should allow parents and grandparents with disabilities to participate as well.”

4. Combination treatment can increase human insulin-producing cells in vivo

“[Diabetes-model mice] were treated with the combination therapy [of a plant product called harmine and “a widely used class of type 2 diabetes therapy”] and their diabetes was rapidly reversed. Strikingly, human beta cell numbers increased by 700 percent over three months with this drug combination. "This is the first time scientists have developed a drug treatment that is proven to increase adult human beta cell numbers in vivo. This research brings hope for the use of future regenerative therapies to potentially treat the hundreds of millions of people with diabetes," said Dr. Garcia-Ocaña, the paper's corresponding author.”

5. Decades of Dedication: Australia’s Largest Ongoing Urban Restoration Project

“[Friends of Lake Claremont] has transformed the area into a thriving ecosystem, re-establishing native habitats and fostering biodiversity. This year, 800 native seedlings (100 trees, 350 shrubs and 350 ground covers) have been planted on the northwestern buffer of Lake Claremont. Volunteers replaced a large Port Jackson fig (Ficus rubiginosa) affected by [beetle] infestation with native plants to enhance the local wildlife habitat, thereby benefiting insects, frogs, birds and brown bandicoots. […] Overall, the project contributes to the area’s function as a regional ecological corridor, linking inland bushlands, the Swan River and the Indian Ocean.”

6. Important habitat for fish in Heart of the Fraser now conserved

“British Columbia’s iconic salmon now have more protected spawning habitat in the lower Fraser River, thanks to the Nature Conservancy of Canada’s (NCC’s) conservation acquisition of Carey Island. […] Carey Island and its gravel channels offer calm and crucial spawning and rearing habitat for the river’s fish and aquatic species. […] The Pelólxw Tribe […is also] actively working to restore the resilience of aquatic habitat within this stretch of the Lower Fraser. NCC is exploring opportunities to collaborate with the Pelólxw Tribe in support of their vision for stewardship of the area, which prioritizes both ecological and cultural values.”

7. Prime editing efficiently corrects cystic fibrosis mutation in human lung cells

“[R]esearchers have developed a gene-editing approach that efficiently corrects the most common mutation that causes cystic fibrosis, found in 85 percent of patients. With further development, it could pave the way for treatments that are administered only once and have fewer side effects. The new method precisely and durably corrects the mutation in human lung cells, restoring cell function to levels similar to that of Trikafta [the standard treatment since 2019].”

8. Montana’s High Court Considers a Constitutional Right to a Stable Climate

“At issue was the appeal of a decision last year, when a Montana judge blocked a state law that prohibited agencies from considering climate impacts when deciding whether to approve fossil fuel projects such as new power plants, pipelines or mining. The ruling, by District Judge Kathy Seeley, was prompted by a lawsuit filed by 16 youths who argued that the law violated Montana’s constitutional right to a “clean and healthful environment.” It was the first ruling in the United States to effectively establish constitutional rights to a stable climate[….]”

9. The US is about to get its first solar-covered canal

“The first canal-based solar project in the U.S. is nearing completion on tribal lands south of Phoenix, Arizona. […] The long, narrow solar array design would snake along the line of the canal and tap into the local electrical distribution grid every 1,000 feet, or every one megawatt. […] “Canal solar allows for greater power production per land size, cleaner water, less power transmission losses, and significant reduction in evaporation[….]” Covering the entire 8,000 miles of canals and waterways managed by the Bureau of Reclamation with solar panels could generate over 25 gigawatts of renewable energy and reduce water evaporation by tens of billions of gallons[….]”

10. Camera traps offer glimpse of first beaver born in Northumberland for 400 years

“"It’s such a relief that they have bred successfully and to see a new fluffy kit swimming with the family[….]” In just one year [since releasing the beavers], there has been a noticeable increase in resident trout, says the National Trust, along with more regular visits from kingfishers and grey herons. There are more insects at the site, too, thanks to the organic matter that builds up behind the dams, which in turn provides food for Daubenton’s bats. […] Beavers also play an important role in creating habitats that are more resilient to the effects of climate change[….]”

July 1-7 news here | (all credit for images and written material can be found at the source linked; I don’t claim credit for anything but curating.)

[palms-upturned]

Hello this a long shot call, am a citizen of Palestine. I am here to request for your support to help get my insulin (Humalog), just an injection for today to save my life please I beg.I was diagnosized with type 1 diabetes and due to current situation in Gaza I'm unable to get my insulin injection as a result I'm here begging for little financial support to help me purchase insulin for this week. Am sorry if am sending you again this request, kindly donate any amount please. My donation link is in my pinned post🇵🇸

Everyone, keep your eyes peeled. This user is a known scammer. If you get any asks with this copy/pasted message, or from an account using this profile picture, it’s not real.

This person’s main donation post has “verified/vetted” in big red letters at the top. It is a lie. That’s why they don’t tag the person who supposedly verified them or provide a link. Even if a user claims to be verified, it’s important to double check. Cross reference el-shab-hussein and nabulsi’s spreadsheet and the Operation Olive Branch spreadsheet, and search the url/keywords from the fundraiser title in tumblr’s search bar. I have links to both spreadsheets, as well as gazafunds.com, in my pinned post. When answering an ask like this for a user that’s actually legit, linking to the verification will make it a lot easier for people to donate and share without hesitation.

I recognized this person immediately because el-shab-hussein has posted about this scam several times. I don’t have a link handy to any of Hussein’s posts about them, but people have been very kindly linking to these two users/posts so that when you search this url, you find proof of the scam.

An unverified fundraiser doesn’t always mean that it’s not legit, and I’ve been contacted by a lot of people who may not have been vetted at the time, but later on someone did verify them. It’s not necessarily a good idea to block unverified users right off the bat. I keep a list of users to search periodically for verification (or confirmation of a scam, if that is the case). But this person is a very well known scammer. If they contact you, just keep on sharing the proof of the scam and tell your followers to beware.

[ingredientsonline]

9 Different Types of Magnesium and Their Benefits

[batboyblog]

Things Biden and the Democrats did, this week #7

Feb 23-March 1 2024

The White House announced $1.7 Billion in new commitments from local governments, health care systems, charities, business and non-profits as part of the White House Challenge to End Hunger and Build Healthy Communities. The Challenge was launched with 8 billion dollars in 2022 with the goal of ending hunger in America by 2030. The Challenge also seeks to drastically reduce diet-related diseases (like type 2 diabetes). As part of the new commitments 16 city pledged to make plans to end hunger by 2030, the largest insurance company in North Carolina made nutrition coaching and a healthy food delivery program a standard benefit for members, and since the challenge launched the USDA's Summer EBT program has allowed 37 states to feed children over the summer, its expected 21 million low income kids will use the program this summer.

The US House passed a bill on Nuclear energy representing the first update in US nuclear energy policy in decades, it expands the Nuclear Regulatory Commission and reduces reducing licensing fees. Nuclear power represents America's single largest source of clean energy, with almost half of carbon-free electricity coming from it. This bill will boost the industry and make it easier to build new plants

Vice President Harris announced key changes to the Child Care & Development Block Grant (CCDBG) program. The CCDBG supports the families of a million American children every month to help afford child care. The new changes include capping the co-pay families pay to no more than 7% of their income. Studies show that high income families pay 6-8% of their income in childcare while low income families pay 31%. The cap will reduce or eliminate fees for 100,000 families saving them an average of over $200 a month. The changes also strength payments to childcare providers insuring prompt payment.

The House passed a bill making changes to the Small Business Administration’s 8(a) program. The 8(a) is an intensive 9 year program that offers wide ranging training and support to small business owners who are socially and economically disadvantaged, predominantly native owned businesses. Under the current structure once a business reaches over 6.8 million in assets they're kicked off the program, even though the SBA counts anything under $10 million as a small business, many companies try to limit growth to stay on the program. The House also passed a bill to create an Office of Native American Affairs at the SBA, in order to support Native-owned small businesses.

The White House and HUD announced steps to boost the housing supply and lower costs plans include making permanent the Federal Financing Bank Risk Sharing program, the program has created 12,000 affordable housing units since 2021 with $2 billion and plans 38,000 additional units over ten years. As well as support for HUD's HOME program which has spent $4.35 billion since 2021 to build affordable rental homes and make home ownership a reality for Americans. For the first time an administration is making funds available specifically for investments in manufactured housing, $225 million. 20 million Americans live in manufactured housing, the largest form of unsubsidized affordable housing in the country, particularly the rural poor and people in tribal communities.

The Department of Energy announced $336 million in investments in rural and remote communities to lower energy costs and improve reliability. The projects represent communities in 20 states and across 30 Native tribes. 21% of Navajo Nation homes and 35% of Hopi Indian Tribe homes remain unelectrified, one of the projects hopes to bring that number to 0. Another project supports replacing a hydroelectric dam in Alaska replacing all the Chignik Bay Tribal Council's diesel power with clear hydro power. The DoE also announced $18 million for Transformative Energy projects lead by tribal or local governments and $25 million for Tribal clean energy projects, this comes on top of $75 million in Tribal clean energy projects in 2023

Transportation Secretary Pete Buttigieg put forward new rules to ensure airline passengers who use wheelchairs can travel safely and with dignity. Under the planned rules mishandling a wheelchair would be a violation of the ACAA, airlines would be required to immediately notify the passenger of their rights. Airlines would be required to repair or replace the wheelchair at the preferred vendor of the passenger's choice as well as provide a loaner wheelchair that fits the passenger's needs/requirements

The EPA launched a $3 Billion dollar program to help ports become zero-emission. This investment in green tech and zero-emission will help important transportation hubs fight climate change and replace some of the largest concentrations of diesel powered heavy equipment in America.

the EPA announced $1 Billion dollars to help clean up toxic Superfund sites. This is the last of $3.5 billion the Biden administration has invested in cleaning up toxic waste sites known as Superfund sites. This investment will help finish clean up at 85 sites across the country as well as start clean up at 25 new sites. Many Superfund sites are contained and then left not cleaned for years even decades. Thanks to the Biden-Harris team's investment the EPA has been able to do more clean up of Superfund sites in the last 2 years than the 5 years before it. More than 25% of America's black and hispanic population live with-in 5 miles of a Superfund site.

Bonus: Sweden cleared the final major barrier to become NATO's 32nd member. The Swedish Foreign Minster is expected to fly to Washington to deposit the articles of accession at the US State Department. NATO membership for Sweden and its neighbor Finland (joined last year) has been a major foreign policy goal of President Biden in the face of Russian aggressive against Ukraine. Former President Trump has repeatedly attacked NATO and declared he wants to leave the 75 year old Alliance, even going so far as to tell Russia to "do whatever the hell they want" with European NATO allies

[theambitiouswoman]

GUT HEALTH: How it Affects Your body 🍽️🤍✨

Having a healthy gut is important because it plays a central role in the overall functioning of your body. The state of a healthy or unhealthy gut affects all of these things:

Digestion and Nutrient Absorption: The gut's main role is to break down food and absorb important nutrients, including vitamins and minerals. When the gut is healthy, it digests food effectively and maximizes nutrient absorption. When it is not, it can result in digestive issues such as bloating, gas, and diarrhea, as well as nutrient deficiencies.

Immune System Support: About 70% of our immune cells are located in the gut. A balanced gut supports a strong immune response, helping the body fend off illnesses and reduce the risk of infections.

Emotions and Mood: The gut and brain are intricately connected through the gut-brain axis. The gut produces many neurotransmitters, including serotonin, which regulates your mood. An imbalanced gut can influence mental health, leading to issues like anxiety, depression, and even cognitive impairments.

Hormonal Balance: The gut plays a role in the production and modulation of certain hormones. This can impact various bodily functions, from stress responses to reproductive health.

Weight Management: The gut microbiome can influence metabolism, appetite, and fat storage. An imbalanced gut can lead to weight gain and metabolic disorders.

Protection Against Chronic Diseases: Poor gut health has been linked to a higher risk of chronic diseases, including type 2 diabetes, cardiovascular disease, and certain types of cancer.

Detoxification: The gut plays a role in eliminating waste products and toxins from the body.

Inflammation Regulation: A healthy gut can help regulate inflammation in the body. Chronic inflammation, often resulting from an imbalanced gut is a root cause of many diseases.

Skin Health: There's a connection between gut health and skin conditions. Issues like acne, eczema, and rosacea can be influenced by the state of the gut. An unhealthy gut can lead to inflammation, which may manifest as skin issues.

Barrier Function: The gut lining acts as a barrier, preventing harmful substances from entering the bloodstream. A compromised gut lining, often referred to as "leaky gut," can allow toxins and pathogens to enter the bloodstream leading to various health issues.

Production of Vital Compounds: Your gut produces essential compounds, like short-chain fatty acids, which has a lot of positive effects on health from reducing inflammation to supporting brain function.

Sleep Function: The gut produces neurotransmitters and hormones that regulate sleep, such as serotonin and melatonin. An unhealthy gut can disrupt sleep patterns.

[nagichi-boop]

Sonic Disability Headcanons

This’ll be kinda long cuz I want to cover as many characters as possible and I want to include both mental and physical disorders. Spoilers but I made everyone neurodivergent.

Sonic — adhd, Tourettes; chondromalacia patella, chronic migraines (post Frontiers), narcolepsy type 2

Tails — autism, anxiety, cptsd, ocd, morsicatio buccarum (cheek biting); chronic migraines, arthritis (mostly in wrists)

Knuckles — autism, adhd; cfs/me (when away from Master Emerald)

Amy Rose — adhd, bpd; near-sightedness

Shadow — autism, ptsd, cptsd, bpd; unspecified chronic pain (caused by chaos energy, mostly affects knees), cfs/me, chronic migraines, insomnia

Rouge — autism; fibromyalgia, pcos, ibs

Omega — autism

Silver — autism, adhd, anxiety, schizophrenia, chronic motor tic disorder; asthma, pots, eds, fibromyalgia, insomnia

Blaze — autism, ocd, depression, trichotillomania (hair pulling); endometriosis, ibs, lactose intolerance

Cream — autism, anxiety, ptsd; celiac disease, epilepsy

Espio — autism, ocd, ptsd, dpdr; chronic migraines

Vector — autism, adhd; ankylosing spondylitis

Charmy Bee — adhd, dyslexia, dyspraxia, Tourettes; hard of hearing, asthma

Metal Sonic — autism, npd

Sticks — autism, adhd, schizophrenia; eds

Whisper — autism, dyspraxia, depression, ptsd, cptsd; cfs/me, fnd

Tangle — adhd, dyslexia, ptsd; eds, arthritis

Surge — autism, adhd, cptsd, npd, aspd, dpdr; type 1 diabetes (hypoglycaemia), fibromyalgia

Kit — autism, anxiety, depression, dpd, Tourettes, stuttering/stammering; chronic migraines, pots, eds

(I may tweak this as I change my mind or adopt other people’s headcanons, but I wanted to have all my thoughts in one place.)

[reasonsforhope]

"People living with diabetes might have a new hope. Scientists have tested a new drug therapy in diabetic mice, and found that it boosted insulin-producing cells by 700% over three months, effectively reversing their disease.

Beta cells in the pancreas have the important job of producing insulin in response to blood sugar levels, but a hallmark of diabetes is that these cells are either destroyed or can’t produce enough insulin. The most common treatment is regular injections of insulin to manage blood sugar levels.

But a recent avenue of research has involved restoring the function of these beta cells. In some cases that’s started with stem cells being coaxed into new beta cells, which are then transplanted into patients with diabetes. Researchers behind this kind of work have described it as a “functional diabetes cure.”

Now, scientists at Mount Sinai and City of Hope have demonstrated a new breakthrough. Previous studies have mostly involved growing new beta cells in a lab dish, then transplanting them into mice or a small device in humans. But this new study has been able to grow the insulin-producing cells right there in the body, in a matter of months.

The therapy involved a combination of two drugs: one is harmine, a natural molecule found in certain plants, which works to inhibit an enzyme called DYRK1A found in beta cells. The second is a GLP1 receptor agonist. The latter is a class of diabetes drug that includes Ozempic, which is gaining attention lately for its side effect of weight loss.

The researchers tested the therapy in mouse models of type 1 and 2 diabetes. First they implanted a small amount of human beta cells into the mice, then treated them with harmine and GLP1 receptor agonists. Sure enough, the beta cells increased in number by 700% within three months of the treatment. The signs of the disease quickly reversed, and stayed that way even a month after stopping the treatment.

“This is the first time scientists have developed a drug treatment that is proven to increase adult human beta cell numbers in vivo,” said Dr. Adolfo Garcia-Ocaña, corresponding author of the study. “This research brings hope for the use of future regenerative therapies to potentially treat the hundreds of millions of people with diabetes.”

The results are intriguing, but of course being an animal study means there’s still much more work to be done before it could find clinical use. So far, harmine alone has recently undergone a phase 1 clinical trial in humans to test its safety and tolerability, while other DYRK1A inhibitors are planned for trials in humans next year.

Perhaps most importantly, the team will soon experiment with combining beta-cell-regenerating drugs with others that modulate the immune system. Ideally this should help overcome a major hurdle: the immune system will continue attacking new beta cells as they’re produced.

The research was published in the journal Science Translational Medicine."

-via New Atlas, July 14, 2024

[afeelgoodblog]

The Best News of Last Week - March 18

1. FDA to Finally Outlaw Soda Ingredient Prohibited Around The World

An ingredient once commonly used in citrus-flavored sodas to keep the tangy taste mixed thoroughly through the beverage could finally be banned for good across the US. BVO, or brominated vegetable oil, is already banned in many countries, including India, Japan, and nations of the European Union, and was outlawed in the state of California in October 2022.

2. AI makes breakthrough discovery in battle to cure prostate cancer

Scientists have used AI to reveal a new form of aggressive prostate cancer which could revolutionise how the disease is diagnosed and treated.

A Cancer Research UK-funded study found prostate cancer, which affects one in eight men in their lifetime, includes two subtypes. It is hoped the findings could save thousands of lives in future and revolutionise how the cancer is diagnosed and treated.

3. “Inverse vaccine” shows potential to treat multiple sclerosis and other autoimmune diseases

A new type of vaccine developed by researchers at the University of Chicago’s Pritzker School of Molecular Engineering (PME) has shown in the lab setting that it can completely reverse autoimmune diseases like multiple sclerosis and type 1 diabetes — all without shutting down the rest of the immune system.

4. Paris 2024 Olympics makes history with unprecedented full gender parity

In a historic move, the International Olympic Committee (IOC) has distributed equal quotas for female and male athletes for the upcoming Olympic Games in Paris 2024. It is the first time The Olympics will have full gender parity and is a significant milestone in the pursuit of equal representation and opportunities for women in sports.

Biased media coverage lead girls and boys to abandon sports.

5. Restored coral reefs can grow as fast as healthy reefs in just 4 years, new research shows

Planting new coral in degraded reefs can lead to rapid recovery – with restored reefs growing as fast as healthy reefs after just four years. Researchers studied these reefs to assess whether coral restoration can bring back the important ecosystem functions of a healthy reef.

“The speed of recovery we saw is incredible,” said lead author Dr Ines Lange, from the University of Exeter.

6. EU regulators pass the planet's first sweeping AI regulations

The EU is banning practices that it believes will threaten citizens' rights. "Biometric categorization systems based on sensitive characteristics" will be outlawed, as will the "untargeted scraping" of images of faces from CCTV footage and the web to create facial recognition databases.

Other applications that will be banned include social scoring; emotion recognition in schools and workplaces; and "AI that manipulates human behavior or exploits people’s vulnerabilities."

7. Global child deaths reach historic low in 2022 – UN report

The number of children who died before their fifth birthday has reached a historic low, dropping to 4.9 million in 2022.

The report reveals that more children are surviving today than ever before, with the global under-5 mortality rate declining by 51 per cent since 2000.

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That's it for this week :)

This newsletter will always be free. If you liked this post you can support me with a small kofi donation here:

Buy me a coffee ❤️

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[mpreglover225]

Chapter 1: The Journey Begins—Understanding Conception in Expectant Fathers

Introduction

Embarking on the journey to parenthood is an exciting and transformative experience. For expectant fathers, understanding the intricacies of conception is the first step towards a healthy and fulfilling pregnancy. This chapter delves into the biological processes of male fertility, the various methods of conception—including natural intercourse, artificial insemination, and in vitro fertilization (IVF)—and the significance of the monthly heat cycle when ovulation occurs.

The Male Reproductive System: An Overview

Anatomy and Physiology

Understanding your body is essential for maximizing fertility and achieving conception.

Testes: Produce sperm and the hormone testosterone.

Ovaries (Male Ovaries): Specialized organs that release eggs (ova) during the heat cycle.

Heat Cycle: A monthly period of increased fertility when ovulation occurs.

Uterus (Male Uterus): The organ where a fertilized egg implants and develops into a fetus.

Anal Canal: Serves as the birth canal during delivery.

Hormonal Regulation

Testosterone: Influences sperm production and libido.

Estrogen and Progesterone: Regulate the heat cycle and prepare the uterus for pregnancy.

Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH): Control the release of eggs during ovulation.

The Heat Cycle: Timing is Everything

Understanding Ovulation

The heat cycle is a critical window for conception.

Duration: Typically lasts 5-7 days each month.

Ovulation: Occurs mid-cycle, releasing a mature egg ready for fertilization.

Signs of Heat:

Increased body temperature.

Heightened libido.

Mild abdominal discomfort.

Clear cervical mucus discharge.

Tracking Your Cycle

Calendar Method: Mark the start and end of each heat cycle to predict ovulation.

Basal Body Temperature: Measure daily temperature to detect the slight rise during ovulation.

Ovulation Predictor Kits: Detect LH surge indicating imminent ovulation.

Monitoring Symptoms: Be attentive to physical and emotional changes.

Natural Conception: The Traditional Path

Sexual Intercourse During Heat

Engaging in sexual activity during your heat cycle increases the likelihood of conception.

Optimal Timing: 1-2 days before and after ovulation.

Frequency: Regular intercourse every other day during the fertile window.

Positions for Conception:

Positions that allow deep penetration may facilitate sperm reaching the egg.

Remain lying down for 15-20 minutes post-intercourse to aid sperm travel.

Factors Affecting Fertility

Lifestyle Choices:

Nutrition: A balanced diet rich in vitamins and minerals supports reproductive health.

Exercise: Regular physical activity promotes hormonal balance but avoid excessive training.

Substance Use: Limit alcohol and avoid smoking or recreational drugs.

Health Conditions:

Hormonal Imbalances: Can affect ovulation and sperm quality.

Chronic Illnesses: Conditions like diabetes or thyroid disorders may impact fertility.

Medications: Certain prescriptions can interfere with reproductive function.

Assisted Reproductive Technologies (ART)

When natural conception is challenging, assisted methods offer alternative pathways to parenthood.

Artificial Insemination (AI)

Overview: Sperm is collected and directly inserted into the reproductive tract during ovulation.

Types:

Intrauterine Insemination (IUI): Sperm placed directly into the uterus.

Intracervical Insemination (ICI): Sperm deposited near the cervical opening.

Procedure:

Performed in a clinical setting by a healthcare professional.

Sperm can be from a partner or a donor.

Success Rates: Vary based on age, fertility issues, and sperm quality.

In Vitro Fertilization (IVF)

Overview: Eggs and sperm are combined outside the body, and the resulting embryo is implanted into the uterus.

Procedure:

Ovarian Stimulation: Medications stimulate multiple eggs to mature.

Egg Retrieval: Eggs are collected using a minor surgical procedure.

Fertilization: Eggs are combined with sperm in a lab.

Embryo Transfer: One or more embryos are placed into the uterus.

Considerations:

Time Commitment: IVF requires multiple clinic visits and procedures.

Emotional Impact: The process can be emotionally taxing; support is essential.

Cost: IVF can be expensive; explore insurance coverage and financing options.

Intracytoplasmic Sperm Injection (ICSI)

Overview: A single sperm is injected directly into an egg during IVF.

Indications: Used when there are sperm quality or quantity issues.

Procedure: Similar to IVF with the additional step of sperm injection.

Preparing for Conception

Preconception Health Check

Medical Evaluation:

Visit a healthcare provider for a comprehensive health assessment.

Discuss medical history, medications, and any chronic conditions.

Fertility Testing:

Semen Analysis: Evaluates sperm count, motility, and morphology.

Hormonal Tests: Measures levels of testosterone, FSH, LH, estrogen, and progesterone.

Ultrasound Examination: Assesses the reproductive organs for any abnormalities.

Lifestyle Modifications

Nutrition:

Increase intake of folic acid, zinc, selenium, and antioxidants.

Consume plenty of fruits, vegetables, whole grains, and lean proteins.

Exercise:

Engage in moderate physical activity to maintain a healthy weight.

Stress Management:

Practice relaxation techniques like yoga, meditation, or deep-breathing exercises.

Avoid Environmental Toxins:

Limit exposure to pesticides, heavy metals, and endocrine-disrupting chemicals.

Supplements and Vitamins

Prenatal Vitamins:

Start taking prenatal vitamins at least three months before attempting conception.

Omega-3 Fatty Acids:

Support hormonal balance and fetal development.

Consult a Healthcare Provider:

Before starting any supplement regimen.

Emotional and Psychological Preparation

Communication with Your Partner

Shared Goals:

Discuss family planning desires and expectations.

Emotional Support:

Be open about feelings, fears, and hopes.

Intimacy:

Maintain a strong emotional and physical connection.

Coping with Challenges

Infertility Concerns:

Acknowledge that conception may take time.

Seek professional counseling if needed.

Managing Expectations:

Understand that each journey to parenthood is unique.

Building a Support Network

Family and Friends:

Share your plans with trusted individuals.

Support Groups:

Join communities of other expectant fathers or couples trying to conceive.

Professional Guidance:

Consult fertility specialists, counselors, and reproductive endocrinologists.

Conclusion

Understanding the process of making a baby empowers expectant fathers to take proactive steps towards achieving pregnancy. Whether through natural conception during the heat cycle or utilizing assisted reproductive technologies, being informed about your options and preparing both physically and emotionally are crucial components of this journey. Remember, patience and persistence are key, and seeking support along the way can make the experience more rewarding and less daunting.

Key Takeaways

Know Your Cycle: Understanding your heat cycle enhances your ability to conceive.

Healthy Lifestyle: Nutrition, exercise, and avoiding harmful substances improve fertility.

Explore Options: Familiarize yourself with both natural and assisted conception methods.

Emotional Preparedness: Open communication and emotional support are vital.

Professional Guidance: Regular consultations with healthcare providers ensure optimal care.

[covid-safer-hotties]

Global Emergency Compounded by the AIDS-like Features of SARS-CoV-2 Infection - Published Sept 1, 2024

Over a million people in the US are being infected with severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) every day.

Originally named after the acute respiratory syndrome it can cause as a consequence of blood vessel damage in the lungs, SARS-CoV-2 is actually primarily a blood vessel virus that spreads through the airways. It causes a complex multisystem disease (1). It is airborne (2). It can persist in the body, and is detectable in body and brain tissue even at autopsy of “recovered” patients (3).

Each infection ages the body, causes damage to the blood vessels and the immune system, and affects organs including the heart, lungs, liver, kidneys, bones, etc. (4, 5, 6)

Each infection ages the brain. Specifically, it reduces gray matter and cognitive ability (7), and potentially IQ score (8). It increases the risk of psychiatric disorders (9). SARS-CoV-2 has also been identified as contributing to accelerated dementia (10).

The potential post-acute phase impacts of SARS-CoV-2 include long COVID, some manifestations of which are chronic conditions that can last a lifetime, including heart disease, diabetes, myalgic encephalomyelitis and dysautonomia (11).

The Economist has estimated excess deaths from the beginning of the Pandemic through May 2024 at up to 35 million people worldwide. (12)

In Addition, Many Scientists Are Now Issuing Warnings… SARS-CoV-2 triggers a new airborne form of Acquired Immune Deficiency Syndrome (13, 14, 15) (some are proposing specific terms such as “CoV-AIDS”).

This is not AIDS as we know it from human immunodeficiency virus (HIV) infection, it is a new type of acquired immunodeficiency syndrome with different deleterious effects on immune function (16, 17, 18, 19, 20, 21), but both resulting in increased vulnerability to infections (22). Immune system deficiency and other COVID properties also suggest a potential link to greater risk of cancers (23, 24, 25, 26, 27).

The “original” AIDS caused by HIV takes up to around 10 to 15 years to make its presence felt, with the initial infection usually barely noticed and often resembling the common cold or a flu-like disease until its damage manifests itself leading to death in the absence of treatments (28, 29).

With SARS-CoV-2, immunodeficiency develops in the weeks and months following infection. It involves reduction and functional exhaustion of T Cells (30), enhanced inhibition of MHC-I expression (31), downregulating CD19 expression in B cells (32) and other evidence of immune dysregulation (33, 34). In one study, the dysregulation persisted for 8 months following initial mild-to-moderate SARS-CoV-2 infection, the length of the study (35). There is no “cure” for any of the damage caused by SARS-CoV-2 including immune dysregulation.

Did You Know? Repeated infections are leading to prolonged immune dysregulation, and increase the risk of progressive disability and death.

Long COVID is a multisystem disease with debilitating symptoms, which has had a profound impact on society and the global economy. In the USA, economists have estimated that long COVID will incur cumulative future costs of more than US$4 trillion (36, 37).

The worldwide devastating economic consequences of this mass disabling event have been measured in terms of total work hours and GDP lost around the world (38).

It theoretically only takes a single viral particle to initiate an infection, and most infections are initiated by very few viral particles (39).

Despite current popular belief, the immune system is NOT a muscle, and does NOT benefit from being repeatedly challenged with disease-causing microbes. In fact, its finite resources are depleted with each new infection.

Herd immunity is unattainable for a rapidly mutating, immune-disrupting virus, and there is no basis to believe that a vascular infection will evolve into the common cold. Continuing to ignore SARS-CoV-2 will not make it go away. Depriving the virus of publicity does not deprive it of its continuing lethal effects.

SARS-CoV-2 is continuing to evolve and mutate – it is not running out of evolutionary space. It is not a cold or the flu, but primarily a blood vessel disease. It is damaging society as we know it.

How many repeated infections can we expect young people to endure and survive? Even if they get only 1 infection each year, that’s 10 infections in 10 school years. This is not compatible with health and a long life. Repeated infections can lead to long COVID and shortened lifespans.

How Do We Protect Ourselves, How Do We Protect Our Children, When Government Public Health Advice Has Failed?

By reducing transmission so that R0 remains less than one (meaning that each person infects less than one other), we can suppress and gradually eliminate the virus, targeting a safer return to pre-2020 normal.

Handwashing is helpful, but it is not the main way to stop the spread of this airborne virus.

Respirators can block 95% or more of virus particles through electrostatic action, and are therefore highly effective at reducing infection even if only one person in a conversation is wearing them. They are far more effective if all people are wearing them (40).

Transmission can be reduced with HEPA filtration and ventilation of indoor air.

The virus spreads more quickly in indoor settings, but also spreads outdoors.

For medical facilities, it is essential to clean the air with ventilation and filtration and require universal high-quality masking (with N-95/ FFP3 respirators or better) to protect medical staff and patients.

For workplaces, clean air will reduce transmission; and encouraging employees to test and stay home when infectious is essential. High-quality masking should be encouraged in the case of symptoms, a sick person at home, or any other suspicion that one could be carrying the virus. Remote work should be normalized and encouraged wherever possible.

For entertainment venues, events should be held outdoors when possible; and if indoors, clean air is key to protecting audiences. Audiences should also be encouraged to wear respirators to avoid getting infected and infecting others. Digital streaming options should always be offered.

For restaurants, an emphasis on outdoor dining will substantially reduce transmission. Patio service should be encouraged, and indoor dining areas should be well-ventilated with a high level of air-exchanges. Home or curbside delivery offers a safer alternative.

For schools, clean air will reduce transmission; encouraging students to test and stay home when infectious is essential to preserving their health. Masking or remote learning should be initiated whenever a case is detected or the incidence in the general population sharply increases. A permanent hybrid model / digital option can accommodate children with disabilities or those who simply do better learning from home.

Teachers and medical professionals may prefer to use transparent masks, or to wear HEPA-filtered headgear equipment that may be more universally tolerated/accepted.

To track our progress, we need sustained wastewater and population-level testing.

With just 60-70 percent of people taking mitigation measures such as masking, testing and isolating when infected, we can dramatically reduce forward transmission of the virus.

Even with very imperfect measures, as long as one infected person does not infect more than one person on average, the virus will eventually die out. The fewer people each person infects on average, the faster it will happen.

We still have a window of opportunity. Protecting ourselves and our families is in fact protecting the economy and the continued orderly functioning of our society.

[lowkeyrobin]

hi :) i was wondering if i could get somethin with the cricket crew folks (those who are a-okay with xreaders) and a reader who deals with type 1 diabetes, like the reader is having low blood sugar troubles while hanging out pretty please 🦕 (platonic or romantic doesnt, matter to me)

OF COURSEEE OMG sorry for taking so long to get this out, I did a lot of research into this so hopefully I got everything accurate! my dad has type 2 diabetes so sorry if anything got mixed up with that as well 😭 billzo and aimsey are the two that aren't cool with x reader fanfics so I didn't include them, although I'm pretty sure they're okay just being in the bg? lmk if I need to change anything! I genuinley appreciate it ; also all hb content will no longer have tubbo!!

HANDSOME BROS ; you have type one diabetes

includes ; tommyinnit, ranboo, & freddie badlinu

warnings ; swearing, mentions of fainting, mentions of needles/dexcom

masterlist

TOMMYINNIT

instantly shoving bills diet coke down your throat

he just panics at first and kinda asks you what to do

yk like in movies when all the characters are shouting over each other in panic? that's him

bill rushes over since his drink just got stolen

"dude, their dexcom needs changed"

"what the fuck is a dex-com!?"

Tommy's too scared to help you in the beginning, literally forces Bill to help you if you need it

even seeing the damn dexcom app on your phone scares him sometimes

like when you walk too far away and it starts doing that scary ass beeping thing, he jumps out of his skin

you left your phone with him while you went to use the bathroom in a public area and your phone started doing the thing because you were too far away and his face went from 😊 to 😨 in a millisecond

"What if they're dead in there???"

wilbur and tubbo are usually the ones reminding him that you're fine and it beeps when you're out of reach

after time, he gets used to it

although he never lets you forget your phone

he's still scared of the beeping

but he learns a lot on how to help you and shit from both you and bill

if he's got an embarrassing question, he'll go to billzo bc he's so scared of making you uncomfortable LMAO

has a whole notes app list for procedures when you're having issues with your dexcom/blood sugar troubles

makes sure you eat some snacks through the day

🫶🫶🫶🫶🫶 I'm so hopelessly in love

RANBOO

the first time it happens it was while you were out with them and aimsey

you only told the both of them "hey I'm diabetic just so u know" and left it at that

so when you started having blood sugar troubles out and about with them, they didn't know what to do

you kinda had to explain yourself and tell them how to help and stuff

ranboo made a little safe plan after that, now worried that you could possibly faint and stuff

he has a whole like 3 page note on his phone (like size 9 font too) of what to do in certain situations and when to call 911 if needed

he runs it by Bill too in case you guys missed anything

like bi-hourly checkups that your sugar is okay and stuff, making sure the dexcom is working etc etc

makes sure to only take you to restaurants and fast food places where you'll actually eat instead of pulling the "I'm not hungry" bullshit

he's just looking out for you

"we can't go there, y/n won't eat and I haven't seen them eat today. if you guys wanna do that, that's cool, we'll probably run by a gas station or a store to get something for them, though"

"ran, it's fine-"

"shut up. youre eating, you toe muncher"

"WHAT???"

if you're recovering from low sugar and being weasy/feeling like you're gonna faint, he just tries everything to make you smile

from dumb jokes to comfort videos, etc

they'll do anything to make sure you're better than you were before

you and bill have a diabetes competition where you're just talking shit and spewing about how you've got it worse than the other and ranboo just records it 💀💀💀

FREDDIE BADLINU

during the pov you're at a family reunion ranboo stream is the first time you have troubles around your friends

you forgot you needed to change the dexcom and almost halfway through you step out

like half an hour later you're still not back and the whole groups confused to Freddie goes to retrieve you

brother finds you in the bathtub in and out of consciousness

tbh you blame yourself for writing it off and not thinking about a plan just in case but lessons learned

he texts the groupchat to inform the others what happened while you stumble back into frame with Freddie's help bc you were not gonna ruin this for the others or chat, no matter how much he told you that you weren't ruining anything

you were acting a little out of it but he got you eating off the charcuterie board which helped a bit

afterwards, he always makes sure that you're eating properly and helps you with communicating if you need help with your dexcom and stuff

like Tommy, the beeping when you're too far away from your phone scares the shit out of him sometimes

sometimes he gets a little anxious and slides your phone under the bathroom door or quickly gives the phone back like "I'm just making sure you're okay! it disconnected, I got a little worried"

God I'm so head over heels for him 💔💔