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bpod-bpod · 2 years ago

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Liver Delivery

Worldwide, obesity has tripled since 1975, creating a global health crisis. Being obese increases our risk of 13 different cancers, including the most common liver cancer, hepatocellular carcinoma (HCC). If you have HCC, being obese increases your risk of dying by up to four times. Understanding how obesity triggers this cancer is key to identifying at-risk people and finding new treatments. Here, we see a liver (red) from a mouse missing the BNIP3 gene. When scientists treated mice with a chemical that causes HCC, tumours (white) grew faster and bigger in those lacking BNIP3. Researchers also showed that people with HCC and low BNIP3 activity have fattier livers and worse survival rates. This gene slows the growth of HCC by delivering fat stores in the liver to our cellular disposal machinery. Finding ways to switch BNIP3 back on in HCC could be a new strategy to treat the disease.

Written by Henry Stennett

Image from work by Damian E. Berardi and Althea Bock-Hughes, and colleagues

The Ben May Department for Cancer Research, The Gordon Center for Integrative Sciences, W-338, The University of Chicago, Chicago, IL, USA

Video originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in Science Advances, October 2022

You can also follow BPoD on Instagram, Twitter and Facebook

#science #biomedicine #liver #hepatocellular carcinoma #cancer #liver cancer #obesity #fat #tumours #gross appearance #oncology

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freelanceplatypus · 8 months ago

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Dungeon Meshi modern au where both Laois and Falin are food vloggers. Laois is always travelling to remote areas and cultures to try the most "extreme" foods and bring them to light. He's known as the guy who will drink blood and slam a still wriggling bug just to comment on it's nutty flavor. Meanwhile Falin is visiting long-standing eateries and sharing the stories behind local cuisine.

Nobody actually puts together they're siblings (in part due to wildly different viewerbases) until Falin in one video mentions how she enjoys eating insects and the comment section is full of folks asking her to "collab with the bug guy". Her very next video is her and Laois smiling infront of a mukbang style platter of insects and she introduces him as her brother.

#marcille is falins video editor/manager in general #which results in a lot of fancy editing and trip booking #meanwhile laois is working with his crew of senshi and kabru #kabru works as the face getting them in to restricted areas and senshi actually documents these cultures recipes #marcille actually edits laois vids too despite getting so grossed out watching them #meanwhile she makes falin eating blood sausage look like art #chilchuk is just on call at all times to get them in and out of countries #he takes care of scheduling in general you think the touden siblings can keep a calendar #itzumi is the picky eater friend that i feel needs to appear in more food review content #dungeon meshi #delicious in dungeon #modern au #laois touden #falin touden

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orangechickenpillow · 5 months ago

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happy fathers (?) day

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cowardlykrow · 9 months ago

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"Ooooo, you wanna get in my toy box SOOO badd"

#“I’m gonna give him a goatee so grotesque”#Starkid #if you don't try and make too much sense of the pose and terribly planned perspective #this could be fine #Tinky #Like yeah sure sure for sure he technically appears as a teenager in npmd but also what if he also looked like a gross little goat man #t'noy karaxis #Hatchetfield #Hatchetverse #Nightmaretime #Fanart #Art #drawing #Digital art #Digital drawing #NPMD #nerdy prudes must die #Team starkid #- Where i try too hard on art and then im like... hmm - a mistake?

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mrmistakemakeroywg · 4 months ago

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How i feel anytime i see Lord dominator shipped with a man / wander 🤢 |

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(editing these little brackets in to try and avoid people being jumpscared again )

(TW: Wander x dominator images ) /VERYNEGATIVE /ewww EWW EWW

WHAT IS WRONG WITH THESE PEOPLE HELPPP GET ME OUT OF HEREE HELPPP

(Context : )

#wander over yonder #wanderoveryonder #woy wander #wander #wander woy #woy #SLIGHT VENT BECAUSE THIS KEEPS APPEARING ON MY PINTREST RECOMENDED AND ITS SO GROSS EWW STOPPP THATS A LESBIAN !! LEAVE DOMINATOR ALONE :(#WHY DO PEOPLE SHIP DOMINATOR WITH MEN EWWW !!#please tell me im not the only one who hates this :(#GET ME OUT OF HEREE #EWWWW HELPPP IT GETS WORSE ANYTIME I LOOK AT THE RECORDING THIS IS HELL

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shrimpchipsss · 9 months ago

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cumplane complain cumplane

#reposting new art w old art bc i feel REALLY satisfied with how these look next to each other #'femcel cumplane' -picnic n pio #so true #theyre still the same dick joke username guys it doesnt matter that theyre women now #airplane has been wearing the same miku tshirt for several days it is noticeably smelly #cucumber also has gross nerdy tshirts but then tries to appear as a normie in public #cumplane #shang qinghua #shen qingqiu #shen yuan #genderbend #rule 63 #airplane shooting towards the sky #peerless cucumber #peerless melons #i hate these guys #i love these guys

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sluckythewizard · 4 months ago

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'I wont cry for you, I wont crucify the things you do. I wont cry for you, see, when you're gone, I'll still be BLOODY MARY'

#cw blood #SUUUPER SCUFFED LIL WIP THATS BEEN RRRROTTING IN MY FOLDER. OUT!! GET OUT!!!#its almos 2 am and imm gettin high as hrothgar. spruced this up within an hour so i could be shared n eaten #its SUPPOsed to be part ofa bigger doodly page so ofc theres the chance this changes between now n then #fuuuuck shoulda made her dress sparkly. fuckit ill fix it laterrrrr. i havnt posted art in YWEARRS i needed to post something #also i uh. well you see i started losing followers on twitter bc im sooo inactive and i KNOW that shouldnt matter like it should be whateve #but. you see. i lkike when number go up and when it go down i get MMMADDD.we all get our dopamine from somewhere #ANYWAY so i actually havnt touched the suckening in so long. been workin on oc stuff.BUT WELL. ARTHUR AND MARY. STILL MAKE ME WEEP #THEYRE SO CUTE N TRAGIC...whadda fuck is it with grizzly n charlie characters being so in love and so doomed #kian and becky then arthur and his various exes like CMAHn.stop doing this to me #from what i remember of the episode.she seemed so.tired.disconnected.like she had been wandering a dream #and yet she seemed so positive.reasonably concerned and yet.content.she warmed up to arthur as soon as she recognized him #she speaks so gently and so sweetly and she keeps the conversation so light.even though shes dead and shes gone and she #is doomed to wander an odd limbo for the rest of time.and yet she seemed so at peace.i can see why arthur liked her.what happened?#what caused them to separate?arthur seems so jaded and so tired.marys company seems like such a gentle place to rest.#how did he squander such a blessing?was it a blessing?OHH what i would give to crack open their minds and peer inside.#yknow wat im runnign out of room i think so ill add a last thought here at the bottom of my tags. I AM MORE CORRECT ABT ARHTURS UGLY LOOK #I WANT THAT MAN TO BE BEASTLY AND GROSS AND STRANGE AND SCARY AND EEWWW I SEE THINGS SQUIRMING IN THE DARK.ther are bugs #LETTING HIM HAVE HOT HOT ABBS AND STUFF WAS A COP OUUTTTT LET HIS WHOLE FORM BE DISTORTED OR UR NOT A FUCKING 0 APPEARANCE BITCH #THE BONES SHIFTED BENEATH AS IF TRYING TO HATCH. MANY OTHER THINGS HATCHED ASWELL. THE DEAD IMMORTAL FLESH SOURED #TOO GRAND TO ROT BUT TOO CORRUPTED TO KEEP CLASSIC FORM. MMMONSTER MONSTER MONSTER MONSTER #oka y im not going to bed but im gonna go. uh. do miore drugs or something. maybe ill work on more jrwi stuff. or oc stuff.#i hope ur day goes swimmingly thankyou for reading my tags i love you so so so so so much

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unexpectedbrickattack · 1 year ago

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get normaled, idiot

#pizza tower #peppino #arts #mine #anyway....#i cannot for the life of me get it right #i need a ref or something #i have like SUCH a clear image of what i want him to look like and trying to imitate it just makes him look uncanny #like he needs droopier eyes and bigger eyes #and ive seen people who look EXACTLY like the ref i would love to have #ah well #i did get his mouth pretty close to what i wanted :)#other things; he has like a SMALL amount of accessories like necklaces n stuff. i think he is very Particular about his appearance #the balding doesnt bother him AT ALL so its not messed w in anyway #the most hell do is brush it down so its not in the way #and hes got hats for if he simply does not want it to get unruly in the wind #i was stuck deciding between a Normal earring and a stud but i think stud looks a bit better heehee hes got quite a bit of piercings #but hes stopped using them YEARS ago. they havent closed up so like. theoretically he Could use them again. but hes fine w leaving them be #also he is like obv a mess when hes in the back working the oven n stoves so hes sweaty and kinda gross if hes been in there TOO LONG #(and he is SO conscious about this; he gets a better ac unit postgame when he gets more funds)#but otherwise if hes going out somewhere he has like spicy smellin colognes. like the shit that makes ur head hurt when u smell it sdfkjdfj #meanwhile gus does not give a flying fuck #hes got 14-in-1 body wash and a prayer #you get what u get #which is admirable tbh #i just think it is funny for him to be particular about this. gus we are best buds but you are not coming out w me looking like this.#or the noise smells AWFUL bc he is covered in grease and sweat from tinkerin in his room all day #and peppino looks SO upset hes like get AWAY from me u smell like ACTUAL garbage !!!!!!!!!!!!! go get CLEAN you fucking BEAST

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an-albino-pinetree · 9 months ago

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#my stuff #selfship #tree makes an appearance #carnival!jax #carnival au #the amazing digital carnival #if something tries to bite your head off #cough into its open mouth #I SWEAR if ya tag this as vore /j #Im watching you all 👀#tadc #the amazing digital circus #tadc jax #jax #shitpost #gross

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sturgeonrot · 9 months ago

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*taps mic* hello helloooo is anybody there

throws this at you like a grenade. hooooly shit. slash and bash.

#escaped audios #slasher and the basher #gore #-ish idk just in case #body horror #KINDA #also just in case #it feels gross tagging like. smth featuring heavy scarring as body horror. but like its moreso for the mask #because the mask just looks like straight up flesh #speaking of the masks they really arent as 'corny slasher mask' as i wish they could be but im incapable of designing those #if they have any canon appearances then color me stumped be nice to me im the new kid on the block

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carpetbug · 4 months ago

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haircut tomorrow.. dye my hair friday… get lip piercing saturday… get tattoo for birthday in august.. i love customizing my meat suit

#carpetbug talks #not ml #i have not changed my appearance in a hot minute and it’s killing me #i mean I dyed my hair blue and purple in april or may #but it’s already faded to gross blonde and green and pale purple i just need to cover it all up #AND IM SO EXCITED AND ALSO SCARED FOR LIP PIERCING AND TATTOO!!#wait have i talked about my piercings. i have basic lobes + septum + both nostrils #about to get vertical labret #and just kind of always thinking about tongue/bridge/bellybutton/eyebrow piercing

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dukeofthomas · 1 month ago

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DC batfam fits i think are ugly AF

Nightwing in any type of red. it's not his colour and it genuinely repulses me. This isn't dick grayson where is my boy. put the blue back on

Lost days jason. His hair looks like it's greasier than mine after 3 weeks of not washing it. His fit his stubble his hair his face, that's not my boy. This is dave, this is rob, this isn't jason

Gray robin costume. Do i even have to say anything about it? it's just ugly. Who approved of this

#my dc posting #dc #jason todd #dick grayson #damian wayne #being a hater rn #im ngl jason's appearance is the main reason i haven't read lost days. it's just too bad for me to look at #and red nightwing... i'm not kidding when i say it repulses me i actually hate it it's so gross for some reason

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chaika-jpeg-shitpost · 2 years ago

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gardener elias appreciation post

#not to be gross but his rolled sleeves make me feel something ngl #when he appears in the anime in this outfit ill scream #mahoutsukai no yome #mahoyome #the ancient magus bride #tamb #mtny #mahoutsukai no yome manga #mahoyome manga #the ancient magus bride manga #tamb manga #mtny manga #elias ainsworth

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ben-vishwakumar · 1 year ago

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People for some reason: “Ben is ugly”

Me, going full Trent mode: “What? Don’t you dare talk about my best baby boy like that.”

#Ben gross #trent harrison #never have I ever #Fr wtf is this???#you know Ben’s played by a real person right ?? that’s so incredibly uncalled for #dislike the character all u want but clowning on someone’s appearance is not cool #and for the record he isn’t ugly 😒

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crimsonmonsoon · 9 months ago

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I really liked TGCF (obviously… obsessing over Qi Rong still) and I want to try MDZS but I’m put off by sex scenes. Like I want to read it because I know it’s probably really good but I don’t want the smut to ruin it for me.

#art catastrophe #I’m asexual by the way #sex scenes are just not it #kinda gross tbh #I knew the donghua was pretty censored so I have watched a few episodes of that and I sorta like it #I’m currently reading a ballad of songbirds and snakes so I actually can’t jump into it rn anyway #I have a rule of only reading one thing at a time and I’ve been so busy I keep forgetting to read it #an iron widow and fourth wing are also on my reading list #so it’s not like I have nothing to read I just see the Mxtx fandom appears to like mdzs more than TGCF and I wanna see that for myself #svsss idek if I’m contemplating on cause nothing has drawn me to it #svsss #mdzs #tgcf #mo dao zu shi #tian guan ci fu #scum villian self saving system #mxtx #mo xiang tong xiu

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khaotunq · 2 years ago

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idk i just think he's neat ⇢ Khaotung Thanawat as Ayan (The Eclipse, 2022)

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