#fluoroquinolone toxicity

[maggieslighte]

Zebra Hope

I wasn’t disagnosed with a connective tissue disorder that affects every part of my body until I was 52! Misdiagnosis and gaslighting have colored 54 years of my life, so what makes my current doctor so different? This doctor took over my care when my previous doctor left town. She was young, and she expressed that she hadn’t had patients with Ehlers-Danlos Syndrome before. I shared all of the…

[teachingrounds]

CRE = Carbapenem-Resistant Enterobacteriaceae. Carbapenems are a newer class of beta-lactamase antibiotics; CRE bacteria may also be resistant to unrelated drugs such as fluoroquinolones. Enterobacteriaceae is the name of a family of Gram-negative bacteria (E. coli, Klebsiella, Salmonella, etc.), many of which live in the human gut. Some patients came down with CRE after being scoped with the same endoscope as another patient with CRE in their stomach, intestines, or lungs. This category includes bacteria that have certain resistance factors such as KPC , NDM-1, and VIM. Treat with old and/or toxic drugs such as polymyxins, fosfomycin, and (sometimes) aminoglycosides (susceptibility varies).

• KPC = Klebsiella pneumoniae carbapenemase. A resistance factor that helps bacteria survive carbapenems and other beta-lactamase antibiotics. There was an outbreak in an NIH hospital.

• NDM-1 = New Delhi Metallobeta-lactamase 1. First identified in India and now in 140 countries, this plasmid moves promiscuously among different species of bacteria. Bad news for wound infections, pneumonias, meningitis, and blood infections.

• VIM = Verona Integron-Mediated Metallo-betalactamase. Like NDM-1, makes bugs resistant to beta-lactamase antibiotics such as penicillin or ceftriaxone.

[vex-verlain]

Gotta love it when the study you want to read is behind a paywall.

“Fluoroquinolone-Associated Disability and Other Fluoroquinolone-Associated Serious Adverse Events: Unexpected Toxicities Have Emerged in Recent Years.”

DOI: 10.1007/978-3-031-04402-1_1

[agreenroad]

CIPRO, LEVAQUIN, AND OTHER FLUOROQUINOLONES ARE NOTORIOUSLY TOXIC. YOU MUST NEVER TAKE THEM UNLESS IT IS LIFE OR DEATH...

Podcast; https://robertyoho.substack.com/p/318-cipro-levaquin-and-other-fluoroquinolones? This is about the phenomenon colloquially known as “floxing,” and my message might save your life or that of a relative or friend. My knowledge is firsthand—I was poisoned with IV Levaquin without my knowledge for a bogus diagnosis of pneumonia; I had a heart condition, not an infection. It has been 21…

[chuckschmalzried]

Woman Disabled From Fluoroquinolone Toxicity After Use of Common Antibiotic

Woman Disabled From Fluoroquinolone Toxicity After Use of Common Antibiotic https://theheartysoul.com/woman-disabled-fluoroquinolone-toxicity/ Hundreds of thousands of antibiotics are prescribed every year to treat a wide variety of infections. While most of the time they are incredibly helpful, sometimes they can do harm. In a heartbreaking turn of events, a young mother named Hailey Sebert found herself disabled after being prescribed a common antibiotic. Hailey’s story sheds light […] The post Woman Disabled From Fluoroquinolone Toxicity After Use of Common Antibiotic appeared first on The Hearty Soul. via The Hearty Soul https://theheartysoul.com/ May 05, 2024 at 07:00AM

[floxiegeek]

I’m so tired of feeling trapped in my body. There are so many things I want to do but can’t due to pain, weakness, and possible paralysis if I overdo it. My body is a cage and my ability to engage with the world is so limited now. Where can I find joy in this prison?

[maggieslighte]

Zebra Wrangling: Managing those pesky symptoms

Zebra Wrangling: Managing those pesky symptoms

In late summer 2018, I took a trip with my mother to Entwistle, Alberta, in Canada where her mother was born. It had been over a year since I had been injured by an antibiotic prescription and at the time I was diagnosed with a frozen shoulder, but I loved the drive with my mom and the two dogs. On our way to and back to Washington from Alberta, we wound our way through multiple forest fires,…

[theloveandthehorror]

imagine knowing a drug family is known to cause terrible and long lasting neurological side effects, using it to treat something random (like covid), and then being shocked and confused when people develop terrible and possibly long lasting neurological side effects. 

[floxiegeek]

I have a mobility scooter which I use any time I need to walk a distance longer than a few blocks. I have a neighbor who I cross paths with occasionally. He’s a nice guy, but he’s only really seen me in my scooter because I’m coming home from work or elsewhere when I’m in the hall. Last night, I decided to walk downstairs to grab dinner from a restaurant under my building. I waited for the elevator, and he happened to pop out of it. I said, “Hey, how’s it going?” and walked into the elevator, not realizing anything was different than normal, and he said, “Hey........” with an incredibly confused look. I went into the elevator, pushed the button, and then saw him stop walking, confused like he was debating if he should turn around and ask me if I had gotten better or....or what? I finally processed what had happened as the door was closing but it was too late to explain. I ended up having a good chuckle to myself.

I only started using a scooter 9 months ago. So many social interactions change when you use a mobility device. I’m still not used to it. My legs do different things at different times of the day, but sometimes I feel I have an obligation to those around me to hobble around more than I need to so people don’t assume I’m just using a scooter for the hell of it. People need to realize that ambulatory wheelchair users exist - it’ll make for fewer awkward situations for us all.

Standing Up From My Wheelchair in Public

I often bring up the ableist action of harassing/accusing ambulatory wheelchair users (as well as scooter, walker, crutches, and cane users) of “faking” because it’s something that happens ALL the time under the guise of “allyship” that people seem to WANT to remain oblivious to.

A person standing up from a wheelchair or standing without their mobility aid SHOULD NOT be cause for alarm, should not inspire accusations of faking, should not inspire you to say, “it’s a miracle!” in a mocking tone, or to ask me if I should “really be parked here”, or recommendations of weight loss so I won’t “need that chair anymore”, or whispering about how my karma is coming or how I’m going to hell for “playing with a wheelchair”; all comments I’ve received from strangers for just standing in public, getting my chair out of the trunk of my car on my own, or doing something as minimal as riding my chair while being young and smiling.

It’s prejudice; it lacks understanding to how diverse disability is, it uses a singular representation of wheelchair users to judge all wheelchair users. When people are called out on that ableism, those who do it will become defensive and claim to be acting in defense of disabled people because they truly deeply believe in the myth of a “faking disability epidemic", but hear this: non-apparent disabilities/invisible disablities, etc. are REAL disabilities and you are harassing the very people you are claiming to be advocating for.

For me, it is physically very difficult, painful, and risky to walk in the first place, the moments when I am able to, it takes alot of energy and concentration. Emotionally, it takes courage for me to get up from my chair in public; doing so causes anxiety that is parallel to what I would feel as a woman walking alone in the street at night. It’s a situation where I have come to EXPECT harassment and that is not okay. This is not how it should be, getting out of my chair in public should not have to feel like a radical act.

A person who gets up from their wheelchair might have limited ability to walk because they are rehabilitating, have dysautonomia, lung issues, heart issues, chronic pain, hypermobility, fragility of joints or muscles, fatigue, there are so many reasons for being an ambulatory wheelchair user and they come in all ages, sizes, colors, there is no one way, no one look.

[bejeweled-walrus]

today was my 7 month anniversary of being poisoned

[floxiegeek]

[maggieslighte]

The Quality of My Life

I remember laying in bed, circa December 2009, praying that I’d die before I woke. I haven’t wished for that particular sentiment since early March 2010. That’s twelve years. This month is suicide prevention month, but this post isn’t about suicide or the prevention of such, it IS about the quality of my life. There’s something that goes through a person’s mind when they hear the supports that…

[medschoolfool]

Bacteria and Diarrhoea

Clostridioides difficile infection is associated with yellow-white, patchy pseudomembranes on bowel mucosa. These pseudomembranes consist of neutrophil-predominant inflammatory infiltrate, fibrin, bacteria, and necrotic epithelium. Pts may develop non-obstructive colonic dilation known as toxic megacolon, which can lead to colonic perforation. It is an anaerobe, spore-forming, gram-positive rod.

Symptoms: diarrhoea, abdominal pain, and fever developed a colonic perforation.

Histologic findings: "acute inflammatory changes, epithelial necrosis, and a layer of denuded epithelium, fibrin, and inflammatory culls overlaying the mucosa”

Drugs that can alter intestinal flora and therefore cause C. diff infection: clindamycin, fluoroquinolones, and cephalosporins

Produces Toxin A (enterotoxin) and Toxin B (cytotoxin). Disrupt cellular cytoskeletons and intercellular tight junctions, leading to colonocyte apoptosis. Colonic mucosa responds to toxin exposure by forming yellow-white, patchy pseudomembranes.

Toxin A (enterotoxin):

Structure Active site at N-terminal domain (site of glycosylation) Central hydrophobic domain Binding site at C-terminal domain (binds to target surface)

Mechanism of action: binding to brush border of enterocytes → receptor-mediated endocytosis → change of conformation → exposure of active domain → glycosylation of target proteins (e.g., Rac, Cdc42, RhoA) → disruption of actin cytoskeleton functioning → increase in epithelial permeability and apoptosis → diarrhoea

Toxin B (cytotoxin):

Structure Binding site at C-terminal domain Translocation domain (required for pore formation) Cysteine protease-containing domain Catalytic domain

Mechanism of action: same as in toxin A, but can also cause pore formation within the endosomal membrane via insertion of the translocation domain → release of endosomal content into the cytosol → cytopathic effect

Campylobacter jejuni: watery diarrhoea that may become bloody, abdominal cramping, and fever. Neutrophilic infiltrate and crypt abscesses are identified on histology.

Salmonella typhi causes typhoid fever, which manifests with diarrhoea, abdominal pain, high fever, and salmon-coloured macules located mainly on the trunk. Histology demonstrates histiocytes, lymphoplasmacytic inflammatory infiltrate, and associated haemorrhage.

Shigella flexneri: sudden onset of severe abdominal cramping, bloody diarrhoea, vomiting, and high fever. Cryptitis, ulcerations, and crypt abscesses on histology.

Vibrio cholerae: cholera; sudden onset, voluminous, “rice water” diarrhoea and vomiting. Histology normal.