#experimental vaccine

[creativemedianews]

Rwanda initiates vaccine study to stem the Marburg virus spread

[reality-detective]

Dr. Christiane Northrup: Infertility clinics are reporting that the sperm of va<<inated men do not swim. And the eggs of va<<inated women do not grow into embryos. 🤔

[jangillman]

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A post shared by ⭐️ Sylvia | Daughter of Liberty (@simplipolish)

[aressida]

Take a moment to really think about what is happening with conditions like Myocarditis, Pericarditis, Bell's Palsy, Guillain-Barre Syndrome, and Ramsay Hunt Syndrome.

These are not just rare occurrences anymore and it is annoying as they are becoming all too common. And then there is the rise of what some are calling 'turbo cancers, for the past year' where aggressive cancers are showing up suddenly, often in people who seemed perfectly healthy. Even heart diseases are on the rise, affecting younger people who should have had years of good health ahead of them.

As someone who’s spent time digging into what is really going on, especially when it comes to Big Pharma, I cannot help but see a pattern.

These pharmaceutical companies have so much power and influence, and they are not always transparent about the risks their products pose.

What we are seeing now is the fallout from that lack of accountability, and it is something we cannot ignore.

We need to start asking the tough questions and holding these people responsible before more lives are affected.

[negativeohio]

We made a new song, go check it out! Also, remember to get your shots

[creepy-scrawl]

Well... After all... Pain and sadness. . . At least seeing my dog chewing her paws makes me feel better

[bronzetomatoes]

Nearly time 2 hit the hay (it is 9pm)

[ultramaga]

Except that it wasn't relevant at all. Take measles vacc.

It was tested first, it was safe, it stopped people getting it, it was a modified version of the virus.

The manufacturer could be sued if it harmed people.

It was a choice.

The mRNA treatment was none of that, and the goalposts were endlessly moved, so that it would prevent COVID, then largely prevent, then diminish symptoms.

In the end, there was no proof offered it worked beyond Fauci declaring

It had one thing that the measles vacc never had, however. Coercion.

https://www.servicesaustralia.gov.au/who-can-get-support-under-covid-19-vaccine-claims-scheme?context=55953

If you had AstraZeneca Vaxzevria, the following clinical conditions are accepted under the scheme:

Anaphylactic reaction

Capillary leak syndrome

Cerebral Venous Sinus Thrombosis (CVST) without Thrombocytopenia

Guillain Barre Syndrome (GBS)

Thrombosis with Thrombocytopenia Syndrome

Thrombocytopenia, including immune Thrombocytopenia

Transverse Myelitis.

If you’ve had Pfizer/Biontech Comirnaty, Moderna Spikevax or Novavax Nuvaxovid, the following clinical conditions are accepted under the scheme:

Anaphylactic reaction

Erythema Multiforme (Major)

The following clinically diagnosed injuries are also accepted under the scheme, regardless of which TGA approved vaccine you’ve had:

Myocarditis

Pericarditis

The following harm isn’t covered under the scheme: contracting COVID-19

Not safe. Not effective. Limited liability at best for the manufacturer.

And no consent.

The principles of the Nuremberg Code

The 10 points of the Nuremberg Code are:

Voluntary consent of the human subject in the experimentation is absolutely essential.

Fauci was given a blanket pardon by Biden for deeds that would have had him tried and shot.

This week-long arc Peanuts arc ran when the measles vaccination was first developed and widely administered in 1967.  GoComics republished it as part of their rerun strips late last year, but it could obviously stand to go around again.

Big slow claps to everyone who made a 50-year-old PSA relevant, good job everyone we’re doing GREAT

[jenks378]

<blockquote class="twitter-tweet" data-media-max-width="560"><p lang="en" dir="ltr">Life Insurance policy denied to family due to Covid vaccine being a medical experiment …<br>Calling it Death by Suicide🤦🏻‍♀️ <a href="https://t.co/hpdSGhnDll">pic.twitter.com/hpdSGhnDll</a></p>&mdash; “Sudden And Unexpected” (@toobaffled) <a href="https://twitter.com/toobaffled/status/1893304560359194978?ref_src=twsrc%5Etfw">February 22, 2025</a></blockquote> <script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>

[owlindustrees]

[reality-detective]

The military personnel were/are the lab rats, but everything has been scripted to end the lives of billions of people. 🤔

[jangillman]

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[jcmarchi]

A new vaccine approach could help combat future coronavirus pandemics

New Post has been published on https://thedigitalinsider.com/a-new-vaccine-approach-could-help-combat-future-coronavirus-pandemics/

A new vaccine approach could help combat future coronavirus pandemics

A new experimental vaccine developed by researchers at MIT and Caltech could offer protection against emerging variants of SARS-CoV-2, as well as related coronaviruses, known as sarbecoviruses, that could spill over from animals to humans.

In addition to SARS-CoV-2, the virus that causes COVID-19, sarbecoviruses — a subgenus of coronaviruses — include the virus that led to the outbreak of the original SARS in the early 2000s. Sarbecoviruses that currently circulate in bats and other mammals may also hold the potential to spread to humans in the future.

By attaching up to eight different versions of sarbecovirus receptor-binding proteins (RBDs) to nanoparticles, the researchers created a vaccine that generates antibodies that recognize regions of RBDs that tend to remain unchanged across all strains of the viruses. That makes it much more difficult for viruses to evolve to escape vaccine-induced antibodies.

“This work is an example of how bringing together computation and immunological experiments can be fruitful,” says Arup K. Chakraborty, the John M. Deutch Institute Professor at MIT and a member of MIT’s Institute for Medical Engineering and Science and the Ragon Institute of MIT, MGH and Harvard University.

Chakraborty and Pamela Bjorkman, a professor of biology and biological engineering at Caltech, are the senior authors of the study, which appears today in Cell. The paper’s lead authors are Eric Wang PhD ’24, Caltech postdoc Alexander Cohen, and Caltech graduate student Luis Caldera.

Mosaic nanoparticles

The new study builds on a project begun in Bjorkman’s lab, in which she and Cohen created a “mosaic” 60-mer nanoparticle that presents eight different sarbecovirus RBD proteins. The RBD is the part of the viral spike protein that helps the virus get into host cells. It is also the region of the coronavirus spike protein that is usually targeted by antibodies against sarbecoviruses.

RBDs contain some regions that are variable and can easily mutate to escape antibodies. Most of the antibodies generated by mRNA COVID-19 vaccines target those variable regions because they are more easily accessible. That is one reason why mRNA vaccines need to be updated to keep up with the emergence of new strains.

If researchers could create a vaccine that stimulates production of antibodies that target RBD regions that can’t easily change and are shared across viral strains, it could offer broader protection against a variety of sarbecoviruses.

Such a vaccine would have to stimulate B cells that have receptors (which then become antibodies) that target those shared, or “conserved,” regions. When B cells circulating in the body encounter a vaccine or other antigen, their B cell receptors, each of which have two “arms,” are more effectively activated if two copies of the antigen are available for binding to each arm. The conserved regions tend to be less accessible to B cell receptors, so if a nanoparticle vaccine presents just one type of RBD, B cells with receptors that bind to the more accessible variable regions, are most likely to be activated.

To overcome this, the Caltech researchers designed a nanoparticle vaccine that includes 60 copies of RBDs from eight different related sarbecoviruses, which have different variable regions but similar conserved regions. Because eight different RBDs are displayed on each nanoparticle, it’s unlikely that two identical RBDs will end up next to each other. Therefore, when a B cell receptor encounters the nanoparticle immunogen, the B cell is more likely to become activated if its receptor can recognize the conserved regions of the RBD.

“The concept behind the vaccine is that by co-displaying all these different RBDs on the nanoparticle, you are selecting for B cells that recognize the conserved regions that are shared between them,” Cohen says. “As a result, you’re selecting for B cells that are more cross-reactive. Therefore, the antibody response would be more cross-reactive and you could potentially get broader protection.”

In studies conducted in animals, the researchers showed that this vaccine, known as mosaic-8, produced strong antibody responses against diverse strains of SARS-CoV-2 and other sarbecoviruses and protected from challenges by both SARS-CoV-2 and SARS-CoV (original SARS).

Broadly neutralizing antibodies

After these studies were published in 2021 and 2022, the Caltech researchers teamed up with Chakraborty’s lab at MIT to pursue computational strategies that could allow them to identify RBD combinations that would generate even better antibody responses against a wider variety of sarbecoviruses.

Led by Wang, the MIT researchers pursued two different strategies — first, a large-scale computational screen of many possible mutations to the RBD of SARS-CoV-2, and second, an analysis of naturally occurring RBD proteins from zoonotic sarbecoviruses.

For the first approach, the researchers began with the original strain of SARS-CoV-2 and generated sequences of about 800,000 RBD candidates by making substitutions in locations that are known to affect antibody binding to variable portions of the RBD. Then, they screened those candidates for their stability and solubility, to make sure they could withstand attachment to the nanoparticle and injection as a vaccine.

From the remaining candidates, the researchers chose 10 based on how different their variable regions were. They then used these to create mosaic nanoparticles coated with either two or five different RBD proteins (mosaic-2COM and mosaic-5COM).

In their second approach, instead of mutating the RBD sequences, the researchers chose seven naturally occurring RBD proteins, using computational techniques to select RBDs that were different from each other in regions that are variable, but retained their conserved regions. They used these to create another vaccine, mosaic-7COM.

Once the researchers produced the RBD-nanoparticles, they evaluated each one in mice. After each mouse received three doses of one of the vaccines, the researchers analyzed how well the resulting antibodies bound to and neutralized seven variants of SARS-CoV-2 and four other sarbecoviruses. 

They also compared the mosaic nanoparticle vaccines to a nanoparticle with only one type of RBD displayed, and to the original mosaic-8 particle from their 2021, 2022, and 2024 studies. They found that mosaic-2COM and mosaic-5COM outperformed both of those vaccines, and mosaic-7COM showed the best responses of all. Mosaic-7COM elicited antibodies with binding to most of the viruses tested, and these antibodies were also able to prevent the viruses from entering cells.

The researchers saw similar results when they tested the new vaccines in mice that were previously vaccinated with a bivalent mRNA COVID-19 vaccine.

“We wanted to simulate the fact that people have already been infected and/or vaccinated against SARS-CoV-2,” Wang says. “In pre-vaccinated mice, mosaic-7COM is consistently giving the highest binding titers for both SARS-CoV-2 variants and other sarbecoviruses.”

Bjorkman’s lab has received funding from the Coalition for Epidemic Preparedness Innovations to do a clinical trial of the mosaic-8 RBD-nanoparticle. They also hope to move mosaic-7COM, which performed better in the current study, into clinical trials. The researchers plan to work on redesigning the vaccines so that they could be delivered as mRNA, which would make them easier to manufacture.

The research was funded by a National Science Foundation Graduate Research Fellowship, the National Institutes of Health, Wellcome Leap, the Bill and Melinda Gates Foundation, the Coalition for Epidemic Preparedness Innovations, and the Caltech Merkin Institute for Translational Research.

[vaspider]

For your future information, here are medical innovations younger than both the basics of HRT for trans ppl & the first gender-reassignment/gender-confirmation surgery. I put together this incomplete list earlier today bc I was bored:

all organ transplants

most modern vaccines, including the polio vaccine

the gluten-free diet as a treatment for celiac disease

synthetic insulin

oral contraceptives

MRIs

the concept of a "blood bank"

pacemakers

hydrocortisone

ibuprofen

diazepam

artificial hearts

sumatriptan

naproxen (Aleve)

tramodol

dialysis

ECT

ondansetron (Zofran)

chemotherapy

IVF

CPR

CT scans

transdermal patches

liposuction

intravascular stents

penicillin

In case you run into someone talking about how 'experimental' HRT is.

[anyonghalimaw]

i rlly do not think white global northerners understand how fucking bad the anti sinovac psyop was in context of the philippines and other targeted countries being from the global south, with a history of economic and military intervention and destabilization by the usa specifically.

i live in the philippines and sinovac was the only available vaccine for MONTHS of the pandemic. people were fucking dying and we had no pfizer, no j&j, no astrazeneca, no moderna. sinovac was the ONLY vaccine supply we had. and the supply wasnt even enough for even my small city. we do not have the infrastructure to manufacture our own vaccines and tests. we were entirely reliant on imports from other countries who Did have the capacity to manufacture such things

i got up early for several days straight to go to a pop up walk in vaccination site (were talking there by 7:30am) set up in a fucking public basketball court because it was the only way to get vaccinated, and 3 times i had to go back empty handed so to speak after exposing myself to this massive opportunity for transmission because they fucking ran out of shots and prioritized the elderly and disabled and i didnt have my legal pwd (person with disability) card yet. i had to go to a different barangay (local unit of government) to get my shot MONTHS LATER and only got mine because one of my family was in the local govt and reserved some shots for us.

many filipinos use facebook which is where some of the psyop was conducted because you can use it for free on your phone and it is often where news is disseminated. i know we have that joke about People Believing Anything They See On Facebook but i cannot stress enough that people here get local news from fb the same way you (used to) get news from twitter about shit like localized emergencies and whatnot.

because we are third world, you know that the state of our education system is nothing compared to the states. media and news literacy here is dangerously low and the population is sensitive to mis/disinformation, as can be seen during the 2022 presidential elections where the usa Also interfered lol. i cannot stress enough how much of the population was susceptible to this psyop, especially those in poverty who couldnt afford proper education. hell, even educated people fell for this shit. do you think jhunjhun who didnt finish grade 6 would be able to identify disguised foreign intervention that was in his own language?

we were already recovering from public scrutiny of a different vaccine, a dengue vaccine, which lowered public trust in inoculation. and then the usa goes and does THIS??? i cannot emphasize enough that they are directly responsible for the tens and thousands of unvaccinated covid deaths. they are responsible for my friends having to bury their unvaxxed parents and grandparents at the age of 19. they are responsible for mass death and disability.

but were just a country in the periphery. so who cares about us? our lives are worthless to the usa, which is why they admitted that they did this when they would otherwise "never" to their own population. third worlders arent real people to your government. we are merely statistics and a petri dish for experimentation. so who cares if we die? the real important thing isnt our lives, its that the usa has more control over us than china.