#drug absorption

[curiousquill1]

Science Behind Spheronization: Why Shape Matters in Pharmaceutical Production

The pharmaceutical manufacturing world is pretty complex. The size of the particles is one prime consideration that can make a world of difference in achieving quality and effective medicines. At the core of it lies spheronization—the process of converting raw material into uniform spherical particles in order to improve the production efficiency and performance of the final drug product.

Awareness: Spheronization and Its Implication in the Pharmaceutical Industry

Spheronization refers to an advanced pelletizing technique that results in creating nearly round particles from a powder, granules, or other forms of solid. One can even control the process of production by changing the process variable inside a spheronizer. The size distribution is narrow and specific to formulation requirements for spherical particles resulting from the spheronizer.

So why does this round shape make so much difference in pharmaceutical? This is basically because the physical properties are unique which the spherical particle possesses. Compared with irregular particles, the spherical particle has the flowability feature. For this reason, it could easily feed to the equipment smoothly and with consistency—the tableting equipment, and the encapsulation equipment for that matter. It can be compressed to a considerable pressure, hence making sturdy, excellent tablets, capsules, and so forth.

Ultimately, the spherical shape unlocks major benefits through the entire pipeline of pharmaceutical production, from streamlining manufacturing processes to improving quality and performance of the final drug product. That is why spheronization has become an indispensable tool in the modern pharmaceutical industry.

Consideration: Technical Advantages of Spherical Particles

The very simple yet highly creative process on which lies the heart of spheronization involves taking pharmaceutical powders or granules and introducing them to the particular equipment like the spheronizer. Once this is done, a controlled rotation, coupled with friction, ensues, and the smooth agitation makes the particles turn into almost perfect spheres because of a gradual process of forming rounded shapes.

There are many technical advantages of the spherical shape per se. First, an ideally uniform particle size as well as a relatively smooth surface renders spheres better flow and handling properties which are really of great importance for assured dosing that is reproducible in the process of tabletting, encapsulation, or other types of filling operations. This sort of fluidity allows fewer stops of machinery, decreased scrap, and therefore generally increased output.

However, the advantages of spheronization go far beyond making a production process easier. The round shape also plays a very important role in performance and stability of the drug product in the end. Spherical particles are usually characterized by more favorable dissolution profiles and have drug release kinetics that are predictable and reproducible. Further, the size and distribution of spheronized particle sizes may also stabilize the physical properties of formulation, reducing the possibility of segregation or caking over time during storage and shipping.

Conclusion: Practical Applications of Spheronization Technology

The versatility of spheronization technology makes it a valuable tool for a range of pharmaceutical applications. The ability to produce high-quality, spherical particles is one of the key enablers for manufacturers looking to provide effective and reliable drug products for patients—from immediate-release tablets to controlled-release beads.

Another excellent use of spheronization is in multiparticulate drug delivery systems. Uniform spherical pellets or minitablets formed with the help of a dedicated spheronizer allow the formulator to design complex release profiles suitable for the particular physiological requirements of the patient. This precision, as one might expect, is directly translatable into improved clinical performance and patient experience.

There are many other applications where it extends far beyond the drug. Thus, manufacturing fertilizers produce spherical granules, which can improve spreading while reducing dust and will be efficient to apply without creating hazards on workers' safety. For the sphere in ceramics or abrasives, it would increase polishing performance and lessen the amount of wear of the machines.

By passage of time, its importance will continue to augment amongst the pharmaceutical industries about this spheronization technology. Through the application of principles and scientific knowledge for developing uniform, spherical particles to manufacture through a specialized machine that reduces the production line's steps and increases product quality in a final healthcare delivery line that benefits patient well-being.

In situ, raw materials are to be shaped into uniform performing particles—a vital part of the contemporary pharmaceutical arsenal with more complex drug formulations bringing a demand for improvement and spheronization. Total control by pharmaceutical companies in the science behind such a process will unlock new dimensions that can further efficiency, quality, and innovation—all within improved safety and efficacy for patients in medical treatments.

[unohanadaydreams]

With Mayuri's predilection for psychedelics and undermining his opponents, I think the Pernida fight would've been so cool with mushrooms.

Like.

Mayuri messing around with rate of decomposition of a mushroom to counteract Pernida's physical drawing of reishi which he would've started formulating from his extensive knowledge of Quincies reishi absorbing abilities before he necessarily knew Pernida was doing so physically. And better yet, using a certain mushroom to basically treat Pernida like a big old cancer growth. (Like, cue big, wide smile as Mayuri reveals the reishi that Pernida has been absorbing is the reason his advancement is halting. Because he would use that mushroom JUST to say that)

I don't feel he would need to win and would love to see him lose, but I think it just would've been even more fun--for me--and crushing--for Mayuri <3-- if he would've actually applied his exhaustive knowledge of quincy to the Pernida battle if only because he was under the assumption that he would be exclusively fighting quincy in the big quincy war. Don't even think he needs to recognize Pernida as a quincy early on even!

Honestly, appalling that Mayuri doesn't have more canon dabbling with mushrooms. Like using altered cordyceps in his fight with the zombies?? Creating a horrible malformation of a coffin mushroom that decomposes Giselle's zombies in 3 minutes rather than 3 years...................AH.

I feel like it would've fit TYBW more than the weird fantasy thyroid thing that hardly made sense and had me squinting for 15 minutes trying to cobble together even that vague description--fantasy thyroid thing--when reading descriptions of how Mayuri was using Nemu to beat Pernida and reviving Hitsugaya & Matsumoto.

Also, he would still get to make people trip balls and question their sanity, which is part of his pyramid of fulfillment.

ALSO roots and spores are very convenient when trying to bullshit that Mayuri was actually doing something All Along when he definitely was not.

[mini-uzzy]

phamacist info dump in the tags :

i know vitamin c basically neutralizes adhd meds but lemonade good

[starrahcoolership]

what call lore book of the skin your wife and Avalo mom ex not saving you.

[lifechangingtips]

Understanding Anti-Obesity Medications: A Comprehensive Guide

Exploring the Mechanism of Anti-obesity medications: A Comprehensive Guide Understanding the mechanism of anti-obesity medications can seem like a daunting task, but it doesn’t have to be. Let’s break it down in a way that’s easy to digest, no pun intended. If you want more information about diet, please visit my website! Here Understanding Anti-Obesity Medications: A Comprehensive…

[ahopefulbromantic]

Hello Mouthwashing enjoyers, a doctor here

So i finally played the game yesterday and noticed a detail that isn't talked about enough:

10 mg oxycodone for someone in Curly's condition wouldn't do jack as a painkiller. From what i understood, he also takes it only once a day orally. When he's easily at the very top of the analgesic ladder (meaning due to his state he would need the strongest narcotics in the highest doses, preferably intravenously). Especially that 1) idk about the state of his digestive tract but i can venture to say the absorption would be very poor (meaning a big portion of the drug would just pass through his guts without actually going into the body), and 2) he's been taking it for months and oxycodone as an opioid builds tolerance (meaning his organism "gets used to" the drug and gradually needs more for the same effect). He probably feels that himself, that's why he's reluctant to take it throughout the game.

But don't worry, it gets worse!

Because later on, when we find out we're out of meds and find a hidden stash, it turns out to be...

500 mg paracetamol. As in, half a dose you yourself would take for a headache on a good day. It's placebo at best. What's even the point.

So yeah, if any of you playing thought something along the lines of "it's horrible i hate it i hate giving meds to Curly but at least the painkillers make him feel better" No. They don't. They never did. He may moan less but he's not in any less pain. I'm sorry.

[harmeet-saggi]

Winning The Battle Against Obesity: The Role Of Obesity Drugs

Greetings, health-conscious readers! Today, we're delving into a topic that impacts millions worldwide – the ongoing fight against obesity. This topic is close to our hearts because, after all, who doesn't aspire to live a healthy life? In this article, we'll explore the dynamic and ever-evolving world of obesity drugs. We'll discuss the challenges, breakthroughs, and all you need to know about these vital tools in the fight against excess weight. 

Know more

[wellhealthhub]

Diabetes Medication for Weight Loss: An Effective Approach to Manage Diabetes and Shed Pounds

Unearth the profound potential of diabetes medication in facilitating weight loss endeavors. Embark on an enlightening journey to grasp the multifarious types of antidiabetic drugs, discern their intricate mechanisms of action, and appreciate the paramount significance of personalized approaches to treatment. Discover a plethora of answers to frequently asked questions, coupled with comprehensive…

[iconhub2023]

Lipid Control Plus Cholesterol

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[literaryvein-reblogs]

Writing Notes: Poison

References (Forms, Actions & Examples of Poison; Route of Administration; Some Symptoms; What to do if a Poisoning Happens)

400 years back, Paracelsus stated that, “All substances are poisons; there is none which is not a poison.”

If the right dose is taken, it could become a remedy, otherwise poisonous.

Poison - a substance which when administered, inhaled or swallowed by living organism causes ill effects on the body. It is defined also as a medicine in a toxic dose. Toxic substance may be solid, liquid, gas or any environmental agent.

Forms of Poison

Physical form: Gaseous/volatile/vaporous forms of poisons act faster than liquid poisons as they are quickly absorbed. Similarly, liquid poisons act faster than solid poisons. Gaseous or volatile > liquid > solid. For solid poisons, powdered poisons act quickly than the lumps. For example, there are certain seeds that escape the gastrointestinal tract as they are solid, but when crushed, they can be fatal. For solids: powdered > lumps

Chemical form: Few substances like mercury or arsenic are not poisonous as they are insoluble and cannot be absorbed when they are in combination with other substances like mercuric chloride, arsenic oxide, etc. In other cases, the action is vice versa. For example, there are some substances that become inert in combination with silver nitrate and hydrochloric acid and are deadly and poisonous when present in pure forms.

Mechanical combination: The effect of poisons is significantly altered when they are combined with inert substances.

Action of Poisons

Local action: Direct action on the affected site of the body. Examples include irritation and inflammation in strong mineral acids and alkalis, congestion and inflammation by irritants, the effect on motor and sensory nerves, etc.

Remote action: Affects the person due to absorption of that poison into the system of that person. For example, alcohol is absorbed in the system and then it affects the person.

Local and remote actions: Some poisons can affect both local and remote organs. Thus, they not only affect the area with contact to the poison but also cause toxic effect after absorption into the system.

General action: The absorbed poison affects more than one system of the body, for example, mercury, arsenic, etc.

Route of Administration

The route of administration is the path through which a drug, toxin, or poison is taken or administered into the body of a person which is distinguished by the location where any drug is applied. It is mostly classified on the basis of its target:

Topical—has a local effect

Enteral—has a wide effect, i.e., affect the whole system

Parental—follows a systemic action

Poisons are given or taken so that death can occur at once by shock due to stoppage of body’s vital systems.

Route of administration plays a very important role in determination of death by poison as time in which death occurs are fastest in inhaled poisons, relatively slow in injected and lastly when ingested orally.

Some Symptoms

Sore throat

Trouble breathing

Drowsiness, irritability, or jumpiness

Nausea, vomiting, or stomach pain without fever

Lip or mouth burns or blisters

Unusual drooling

Strange odors on breath

Unusual stains on clothing

Seizures or unconsciousness

Examples

Poisons Based on Mode of Action

1. Corrosive poisons

Strong Acid - sulfuric acid, nitric acid, hydrochloric acid

Strong Base - sodium hydroxide, potassium hydroxide, ammoniumhydroxide

2. Irritant poisons

(a) Inorganic:

Metallic - lead, arsenic, mercury, antimony, copper, zinc

Non-metallic - chlorine, bromine, iodine

(b) Organic:

Vegetable - croton oil, castor oil

Animal - snake venom, scorpion venom, spider venom

(c) Mechanical: powder glass, diamond dust

3. Neurotic poisons

Cerebral - alcohol, opium, barbiturates, benzodiazepines

Spinal - strychnine

Peripheral - curare

4. Cardiac poisons

5. Asphyxiants - CO2, CO

Poisons Based on Medicolegal Classification

Homicidal poisons - aconite, abrus precatorius, strychnos nux vomica

Suicidal poisons - opium, barbiturate, organophosphorous, organochloro compounds

Accidental poisons - snake bite, CO, dhatura's seeds as it resembles capsicum seeds

Abortifacient poisons - quinine, calotropis

Stupefying agents - dhatura, chloral hydrate

Agents used to cause body injury - corrosive acids

Cattle poison - abrus precatorius, calotropis

Used for malingering - semicarpus anacardium

Poisons Based on Toxico-analytical Classification

1. Gaseous poisons: methanol, ethanol, benzene, toluene, acetone

2. Volatile substances: ethane, butane

3. Organic Non-volatile substances:

Drugs - opiates and synthetic narcotics, sedatives and hypnotics, stimulants, depressants

Pesticides - insecticides, fungicides, herbicides, rodenticides, nematocides

4. Metallic poisons: arsenic, lead, mercury, antimony, zinc, copper

5. Anion poisons: bromide, cyanide, fluoride, hypochlorite, nitrate, phosphate, sulfide, sulfate

Poisons Based on Physical State

1. Solid: lead, arsenic, mercury

2. Liquid:

Organic - ethanol, methanol, chloroform, acetone

Inorganic - liquid ammonia, liquid sulfur dioxide

3. Gaseous: carbon dioxide, carbon monoxide

Poisonous Fumes or Gases

In the home, poisonous fumes can be emitted from the following sources:

A car running in a closed garage

Leaky gas vents

Wood, coal, or kerosene stoves that are not working properly

Mixing bleach and ammonia together while cleaning, which makes chloramine gas

Strong fumes from other cleaners and solvents

Common Household Products

Oily hydrocarbon products are thin and slippery and can easily suffocate if the substances are drawn into the lungs when ingested. The products can cause chemical pneumonia by coating the inside of the lungs. Products that are required to have a safety lid include:

Baby oils

Sunscreens

Nail enamel dryers

Hair oils

Bath, body, and massage oils

Makeup removers

Some automotive chemicals (gasoline additives, fuel injection cleaners, and carburetor cleaners)

Cleaning solvents (wood oil cleaners, metal cleaners, spot removers, and adhesive removers)

Some water repellents containing mineral spirits used for decks, shoes, and sports equipment

General-use household oil

Gun-cleaning solvents containing kerosene

Oil products that are thicker and more "syrupy" are not as problematic, since they are not as easily inhaled into the lungs.

What to do if a poisoning happens

Swallowed poisons

Stay calm, act quickly, and follow these guidelines:

Get the poison away

If the substance is still in the mouth, make them spit it out or remove it with your fingers (keep this along with any other evidence of what was swallowed)

Do not make them vomit

Do not follow instructions on packaging regarding poisoning because these are often outdated. Instead, call Poison Help to get connected to a local poison center.

Take or send the poison container with you to help the healthcare provider find out what was swallowed.

Poisons on the skin

If someone spills a chemical on his or her body, remove his or her clothes and rinse the skin with lukewarm—not hot—water.

If the area shows signs of being burned, continue rinsing for at least 15 minutes, no matter how much they may protest.

Then call the poison control center for further advice.

Do not use ointments or grease.

Poison in the eye

Flush the eye by holding the eyelid open and pouring a steady stream of lukewarm—not hot—water into the inner corner of the eye.

If this is a child, you may need help from another adult to hold the child while you rinse the eye.

Continue flushing the eye for 15 minutes, and call the poison control center for further instructions.

Do not use an eyecup, eyedrops, or ointment unless the poison center tells you to do so.

Poisonous fumes or gases

If someone breathes in fumes or gases, get him or her into fresh air right away.

If they are breathing without a problem, call the poison center for further instructions.

If they are having difficulty breathing, call 911 or your local emergency service (EMS).

If they have stopped breathing, start CPR and do not stop until they breathe on their own or someone else can take over.

If you can, have someone call 911 right away.

If you are alone, perform CPR for 2 minutes and then call 911.

Be prepared for a poisoning emergency by posting the poison center telephone number by every telephone in your home.

Sources: 1 2 3 ⚜ Writing Notes & References

Writing Notes: Fictional Poisons

[metalheadsforblacklivesmatter]

For the love of the gods. STOP SAYING "CHECK MEDICATION INTERACTIONS" ON MY ACTIVATED CHARCOAL POSTS.

This is what it said if I "check drug interactions" between ibuprofen (a common pain medication) and activated charcoal.

You see how it says "no drug interaction"?

This is what I get when I look up scholarly articles on the effects of activated charcoal.

You see where it says "Activated charcoal will block the absorption"?

Because there's a difference between "that's what activated charcoal does" and "drug interaction".

You're not gonna experience any ill effects of the "drug interaction" You're gonna experience the effects of your chronic pain and other disabilities because activated charcoal makes your meds not work.

-fae

[lonelynpc]

Medical Inaccuracies I Commonly See In Fics

the titanium skull: characters getting hit on the head and just walking it off or having no repercussions.

swiss army doctor: this doctor knows everything about every specialty. bow before them.

that's my son!: a medical professional treats a loved one.

no nurses needed: the doctor does everything.

companionless, powerful, resolute (CPR): a character does CPR for more than 2 minutes without getting fatigued or swapping out without compromising the quality of their compressions.

shocking asystole: it is simply not a shockable rhythm. please, stop shocking asystole.

'tis but a scratch: a character coughs up or vomits blood but then is fine. also when someone gets shot or stabbed in the hand, leg or shoulder with no lasting impacts.

sims pregnancy: character takes a test the morning after and it's positive.

a refreshing nap: comatose patients waking up and moving around immediately.

neck needles: a character injects something into someone's neck with ease, i guess their neck veins are just magnetised or something.

zap zap: electrocution with no burns, entry or exit, nerve or cardiac damage, dislocations, etc. did you know one of the causes of the less common posterior shoulder dislocation is electrocution?

i don't need this anymore: character gets stabbed and pulls. out. the. blade. to no ill effect.

tourniquets, tourniquets and more tourniquets: a character is bleeding? oh no, time to grab the TQ.

calm, level-headed, tranquil: this character is such a seasoned professional that they don't get an adrenaline rush anymore.

one-way ticket to the afterlife please: character uses a medication or treatment that would do the opposite of treating their condition but it works somehow. (hypoglycaemic patient uses insulin for example)

bumper cars: character is in a major car accident and just walks away with minor injuries.

here's all that confidential information you ordered: character asks for an update on an injured or sick character and the staff just give them the information without consent.

instant absorption: character is given a drug and it works immediately.

[againstme]

idk man i’m just thinking about against me! and transness, especially cause we’re coming up on ten fucking years of transgender dysphoria blues, on the 21st.

lyrics have been swimming in my head lately.

“what god doesnt give to you, you’ve got to go and get for yourself.”

“if i could’ve chosen, i would’ve been born a woman. my mother once told me she would’ve named me laura. i’d grow up to be strong and beautiful like her.”

“you wouldn’t think something like gender identity would complicate something like asking for some company.”

“she spent the last few years of her life running from the boy she used to be.”

“standing naked in front of that hotel bathroom mirror, in her dysphoria’s reflection, she still saw her mother’s son.”

“agitated states of amazement, never quite the woman that she wanted to be.”

“you want them to see you like they see every other girl, they just see a faggot, they hold their breath not to catch the sick.”

“chipped nail polish and a barbed wire dress. is your mother proud of your eyelashes? silicone chest, and collagen lips. how would you even recognize me?”

“no more troubled sleep, there’s a brave new world that’s raging inside of me.”

“all my life, wishing i was one of them. there will always be a difference between me and you.”

“what’s the best end you can hope for? pity fucks and table scraps?”

“all the young graves filled, don’t the best all burn out so bright and so fast?”

“sometimes at night, i pray to wake a different person in a different place.”

“i don’t want to hang around the graveyard, waiting for something dead to come back. i know you think you’ve got one up on me, that you can see something i can’t.”

“i wanna be so real, you can see the difference.”

“dig up your bones, early graves are not homes.”

“come on, shape shift with me! what’ve you got to lose? fuck it!”

“confessing childhood secrets of dressing up in women’s clothes, compulsions you never knew the reasons to.”

“i’m sick of feeling like i’m losing my mind. sick of doing the same things most nights after night. sick of self loathing and self absorption, self destructive narcissism.”

some of these are directly referencing transness, some just alluding to it. some are just ones that i relate to as i’ve grown up struggling with my gender and sexuality and accepting my own transness and dealing with self harm and self destruction and relying too much on drugs.

finding myself buying baggies of coke and just stuffing them in my wallet while i walked downtown, feeling this immense guilt at the bottom of my stomach for essentially just wasting 25 dollars on a drug that wasn’t doing much for me besides making me feel like i was feeling something different than what my life was. getting scared shitless while in the line at the convenience store after picking up, seeing cops come into the store, and the small tied up bag filled with what was more baby powder than coke in my back pocket felt like the the heaviest and most obvious thing in the world.

and then i’d find myself on calls with my friends, with my camera turned off or pointing at the ceiling, suddenly muting my mic holding a cut up piece of a straw in my teeth as i crushed shit up with my library card from a city i wasn’t planning on living in again. just having them talk while i was racking baby lines, tilting my head back and rubbing it on my gums after. i was sniffling all the time. sometimes my nose would bleed when i would wake up. and i wasn’t even really feeling much; i didn’t know at the time that this would be because of having adhd and just basically spending money on overpriced shit that was just like taking an adderall, but it was a drug in front of me, that gave me the idea or the false hope of running away from my life during the short lived high.

“before you know it, here i am again, fucking 6 o’clock in the morning, rolled up dollar bill in my hand.”

“what the fuck are you cutting this with, anyway?”

“how low can you go before you can’t turn around?”

i don’t think that when i was 14 and getting into against me! that i would ever actually get to a point of fully relating to those lyrics. of running away from such a huge part of yourself or your problems, trying to fill the void with drugs that you’d plow through so quickly, faster than you thought you would every time.

the thing is, was that at this point, i had already started my transition. i was already “passing.” but i never got to the root of it. sure, i’m trans, but who am i? and i didn’t know how to answer that question. so i just pushed it away, pushed it under the rug.

“you can pray all night and day, but you’ll still wake up the same person in the same fucking place.”

against me! has been there for me for ten years. throughout so many transformations of myself, so much shape shifting, so much dysphoria, so many late nights wishing i was a different person in a different place.

i found solace in their lyrics. it gave me some small bit of hope, some realization that i didn’t know that i needed; that trans people always have been and always will be here, that being able to be trans and be alive is possible, and that i don’t have to be digging my own grave, spending late nights staring at the mirror and seeing the girl who i used to be.

against me! gave me the courage to be alive.

[lifechangingtips]

Understanding Anti-Obesity Medications: What You Need to Know

Exploring the Efficacy of Anti-Obesity Medications: A Comprehensive Guide Anti-Obesity Medications: Understanding Their Role in Weight Loss Introduction Obesity is a significant global health concern that can lead to chronic conditions such as diabetes, heart disease, and certain cancers. For many, lifestyle changes like diet and exercise are the first steps in managing obesity. However, some…

[xyymath]

Real-Life Uses of Calculus

Calculus isn’t just an abstract, ivory tower concept relegated to textbooks—it’s a powerful tool woven deeply into the fabric of our daily lives, from the precision of medical dosage to the unpredictability of the stock market.

1. Medicine: Optimizing Drug Dosage

Calculus plays a key role in pharmacokinetics, the branch of science that deals with the absorption, distribution, metabolism, and excretion of drugs in the body. When doctors prescribe medication, they need to ensure that drug levels remain within therapeutic bounds, not too high to cause toxicity and not too low to be ineffective. This is where differential equations, a core part of calculus, come into play. The rate of change of drug concentration over time is modeled with calculus to determine optimal dosage and scheduling for sustained, effective drug levels.

Take antibiotics, for example: they must be administered at specific intervals to maintain an effective concentration in the bloodstream while preventing bacterial resistance. Calculus allows for the continuous monitoring of drug levels and the adjustment of dosages based on individual metabolism rates, ensuring maximum therapeutic benefit.

2. Physics and Engineering: Motion and Forces

In classical mechanics, calculus is used to describe motion. Newton's laws of motion and universal gravitation are based on derivatives and integrals, the foundational elements of calculus. The change in velocity (acceleration) is the derivative of position with respect to time, while the area under the velocity-time graph gives us the distance traveled.

For instance, when designing cars, engineers use calculus to model the forces acting on the vehicle, such as friction, air resistance, and engine power. Calculus helps optimize everything from fuel efficiency to safety features, ensuring that a car can handle various conditions without exceeding performance thresholds.

3. Economics and Finance: Predicting Stock Market Trends

In economics, calculus is used to understand and predict market behavior. The concept of marginal analysis—examining the effects of small changes in variables—relies heavily on calculus. For example, marginal cost is the derivative of total cost with respect to quantity, and marginal revenue is the derivative of total revenue with respect to the quantity of goods sold.

In the stock market, calculus is utilized in quantitative finance to model stock prices using stochastic differential equations. Techniques like Black-Scholes for options pricing rely on calculus to determine the fair price of financial derivatives by analyzing how small fluctuations in stock prices impact their expected value. The concept of risk management—how much risk is worth taking for a given return—also uses derivatives to evaluate the rate of change of potential outcomes over time.

4. Environmental Science: Climate Modeling

Climate change models are inherently tied to calculus. Calculus is used to model the flow of energy through the Earth's atmosphere, oceans, and land, and how this energy affects global temperatures. The change in temperature over time is governed by differential equations, accounting for factors like greenhouse gas emissions, solar radiation, and ocean currents. As a result, climate scientists use calculus to predict future climate scenarios under various emission levels, helping inform policy decisions on global warming and sustainability.

5. Computer Science and Machine Learning: Optimization Algorithms

In machine learning, algorithms are designed to optimize a given function—whether it's minimizing the error in predictions or maximizing efficiency in a task. These algorithms often rely on derivatives to find the minimum or maximum of a function. For example, gradient descent, a popular optimization algorithm, uses the derivative of a function to iteratively adjust parameters and reach the optimal solution.

In computer graphics, calculus is essential for creating smooth curves and realistic animations. The mathematical process of curvature, which is the rate of change of direction along a curve, is vital for rendering images in 3D modeling and augmented reality.

6. Astronomy and Space Exploration: Orbital Mechanics

In space travel, calculus is crucial in calculating orbits, trajectories, and spaceship velocity. The path a spacecraft takes through space is influenced by gravitational forces, which can be modeled using calculus. For example, NASA’s mission to Mars relied on calculus to calculate the optimal launch window by accounting for the positions and motions of both Earth and Mars, ensuring the spacecraft would reach its destination efficiently.

[duraxxor]

Azerite. I'm dying to know how he reacts to that in his drink. - Azalora

There was a time back in the era of the Fourth War where Duraxxor was known as the Faceless under an organization that he followed alongside Malakortana and later when Myotis was once a group name. This was some time after his second death. He came into contact with the very substance you speak of. Azerite. In all its brilliance, never would he had thought to have come in contact with crystallized blood of the very planet. This world was far more living than it was a husk of elements and magical leylines.

And Duraxxor, being as he is particularly drawn to blood would partake in an experiment. He obtained the liquified version of the element. Various tests showed that it wasn't poisonous at first glance. In fact, what was bizarre was how this essence brought about some of the greater things in people, for better or worse. There was a page in a journal that the Lord had recorded in this experiment as follows.

" When I drank of her blood, I didn't know what I was expecting. The mixture seemed to possess the distinct taste of pomegranate for me. Which was practically impossible as I couldn't even remember what sort of thing it tasted like. And then, it hit me. I felt an energy sizzle through my veins as it worked its through my absorption. It was spectacular. My new -arm- finally felt as though it were truly a part of my body. And my mind began to race with ideas. Ideas that didn't follow a path of domination. No. Ideas that would possess freedom... " - Azerite entry 1

But his deeds wouldn't end there as he would later experiment with Azerite in a similar manner, but he would drink of it as a concentrate rather than a mixture of sanguine fluid.

" The lifeblood of Azeroth has many, potential uses but mine seems more aligned with using it more like a catalyst. I could still feel the effects from before. A high that reinforced my mind. It was like a drug. I felt much like the Wretched coming off of it before. And yet, I didn't degrade. So, I am going to try a concentrate of it. "

" At first, it was similar to the previous encounter. But like a blazing campfire, my stomach was lit aflame with a billowing warmth. It radiated all throughout my body, my veins appeared to have been fissures through my skin. I thought in a brief panic, I thought I had ingested too much. That was, until the golden hues with cyan undertones suddenly shifted, turning a sanguine brilliance in the palm of my hands. I felt... joy. My imagination running wild as the smile on my face solidified. I was in high spirits and my mind was thinking ahead of itself at a speed I wasn't used to. I felt as though I could tear down the walls of Orgrimmar with my strength. "

" Deep inside the core of my being, I felt a shift like no other. As if my body was merely an extension of what and who I was. Like it was a separate entity from the soul of my being. And something took shape in that small pocket. A core. An engine. Ever since, my existence has been altered, and my evolution progressed in a way that I didn't even think possible. It was glorious. " - Azerite Entry 23

And that was the last time Duraxxor had come in contact with Azerite in such a way. It brought this amazing feeling within him and even altered his history forever. If it wasn't for Azerite, he may have never left stagnation or even followed the path he went. And even now, Azerite seems to be peeking back into his life through a certain dragoness that fatefully met him in Silithus one day.

[[ Tagging @azalora-the-azerite-dragoness and @sanguinesorceress for continuity. I would also like to tag @miah-ambershade @gravekeeper-anna and if I missed anyone that is active, I apologize, for the connections with those organizations mentioned. ]]