#Statins

[kramlabs]

[macgyvermedical]

Hi there!

I just came across your post about the pharma led guidelines (I am a family nurse practitioner) and I was wondering if I could get your sources for the statin info. I’ve been trying to convince my father to stop taking his as I don’t believe it has any benefit to him and as you were saying pharma is enforcing medical guidelines that put more people on medications unnecessarily. But he is a science/evidence guy and I am trying to build up some sources before bringing it up again. Your help would be so appreciated!

Take care and have a merry Christmas!

The info in the post is from a book called Sickening, by John Abramson, MD MSc. He is a statistician and did the math himself, though he does not mention which specific studies he took the data from.

I would direct you to a website site called thennt.com that does a very good job at breaking down the math and studies surrounding statins however, and they do cite sources.

Statins for Primary Prevention for People at Low Risk: https://thennt.com/nnt/statins-persons-low-risk-cardiovascular-disease/

Statins for Primary Prevention for People at Higher Risk Without Prior Heart Disease: https://thennt.com/nnt/statins-for-heart-disease-prevention-without-prior-heart-disease-2/

Statins for Secondary Prevention in People With Heart Disease: https://thennt.com/nnt/statins-for-heart-disease-prevention-with-known-heart-disease/

From these breakdowns, if your father is taking a statin because he already had a heart attack or stroke, the evidence suggests that the drug is worth continuing to take, however, if he has not had a heart attack or stroke, no matter his risk level, the risks of statin therapy (diabetes, myopathy, rhabdomyolysis) outweigh the benefits.

[ricisidro]

RIP. Japanese biochemist Akira Endo, discover of cholesterol-lowering statin drugs, died on June 5, 2024 at age 90.

Statins, prevent heart attacks or strokes. It can help lower the level of LDL or the "bad cholesterol" in the blood and reduce the production of LDL inside the liver.

#lipoprotein #cholesterol #LDL #statins #cardiology

[teachingrounds]

Q. What are the ASCVD primary prevention recommendations for adults with HIV <40 y/o or >75 y/o? Should they also take pitavastatin? . . . . . A. Adults under 40 with no other risk factors should use lifestyle modifications to improve their cardiac profiles, and starting or continuing a statin in adults over 75 should be done on a case-by-case basis.

[eretzyisrael]

Good News From Israel

Israel's Good News Newsletter to 2nd Apr 23

An Israeli-led team has discovered the cause of metastatic pancreatic cancer.

100,000 Muslims say Ramadan prayers at the holiest Jewish site.

The first Shiite Muslim country to open its embassy in Israel.

Israeli scientists create a robot the size of a microscopic cell.

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See why two women (Jewish and Muslim) have formed a special friendship.

Read More: Good News From Israel

It's all go in Israel. As if to answer the Biblical demand to "Let My People Go", Israelis have certainly been "on the go" since my last newsletter. In fact I had to go over my self-imposed limit of 50 positive news items, otherwise I would never have caught up. Israeli scientists are going all out, to make debilitating medical conditions go away. Cancer, diabetes, reflux, muscle pain, heart arrhythmia, cerebral hemorrhage, and respiratory diseases will one day be gone, thanks to Israeli medical breakthroughs. So will religious intolerance, landmines, glass ceilings, water scarcity, pollution, and infant death from heart deformities - all being targeted by Israelis going beyond the call of duty to make a better world. Israeli technology has gone into orbit again with the launch of another satellite; it has made robots go so small that they can control where individual cells go; it can analyze where tiny fragments of broken objects should go; it can find where lost children or missing luggage has gone. Israeli unemployment has gone down again, supermarket prices should also begin to go down soon; Israeli startups are working to make the cost of health care go down; and during Passover visitors can go for free to many Israeli sites and museums.

[mcatmemoranda]

High-intensity statins reduce the risk for recurrent cardiovascular events in patients with established coronary artery disease. Along with lifestyle counseling and cardiac rehabilitation, they should be prescribed to patients who have experienced cardiovascular events. High-intensity statins include atorvastatin, 40–80 mg daily, and rosuvastatin, 20–40 mg daily. Moderate-intensity statins include simvastatin, 20–40 mg daily; atorvastatin, 10–20 mg daily; and rosuvastatin, 5–10 mg daily. Monotherapy with non-statin medications (niacin, ezetimibe, bile acid sequestrants, and fibrates) does not reduce cardiovascular morbidity or mortality. The PCSK9 inhibitors evolocumab and alirocumab are second-line or add-on therapies to maximally tolerated statins. They should be reserved for use in patients who are statin-intolerant or who do not achieve their target LDL-cholesterol level with conventional therapies.

[teachersource]

Joseph L. Goldstein as born on April 18, 1940. An American biochemist. He received the Nobel Prize in Physiology or Medicine in 1985, along with fellow University of Texas Southwestern researcher, Michael Brown, for their studies regarding cholesterol. They discovered that human cells have low-density lipoprotein (LDL) receptors that remove cholesterol from the blood and that when LDL receptors are not present in sufficient numbers, individuals develop hypercholesterolemia and become at risk for cholesterol related diseases, notably coronary heart disease. Their studies led to the development of statin drugs.

[scarabee-hub]

A STATIN FREE LIFE

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Happy listening!

[airbrickwall]

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[surinderbhalla]

Statins and Diabetes Risk: Evidence and Recommendations

Statins and Diabetes Risk: Evidence and Recommendations,"Explore the benefits of statins in lowering cholesterol and preventing cardiovascular events, while also understanding the potential risk of developing diabetes. Backed by scientific studies,

Understanding the link between statins and diabetes risk is crucial for those managing cholesterol levels and overall health. In this blog post “Statins and Diabetes Risk: Evidence and Recommendations,” we delve into the latest research and expert advice on this important topic. Statins are widely prescribed to lower cholesterol, but emerging studies suggest a potential increase in diabetes risk.…

[teachingrounds]

Q. Should pregnant or breastfeeding patients ever take a statin for primary prevention? . . . . . A. "Initiation of statin therapy should be deferred in pregnant individuals at low-to-intermediate ASCVD risk until after pregnancy, and statin therapy should be discontinued if a person with HIV becomes pregnant. Breastfeeding is not recommended while a person is on statin therapy."