#cas9

[twinkdrama]

hey sorry i used crispr on your boyfriend. yeah it deleted his whole dna. im so sorry you had to find out this way

[zeck143]

ideas for Cas9 tactical:

Yes they're all puns, fight me

snap draggin

bites enemies for 10-15 dmg to health, and pings for Cas9 on map

or

pulls multiple enemies to a center point (like ash's snare) for 5-10 dmg, immediate release

take stalk

attaches to first enemy to come by, alerts Cas9 pins outline to them for 5 seconds, can plant multiple stalks

(kind of like Hound, but is triggered rather than instant and can only attach to one player at a time)

(...so sort of like ash’s passive but better)

branch out

creates a small platform to walk across, up to 6(stealing Catalyst's concept tact because I’m still bitter)

thorn down

thorny patch that deals damage and slows because Alec was right when thinking of it first

(fucking catalyst)

aloe there

pulls players within range to 1-2M away, causes 5-10 dmg to enemies(after typing it out, i thought “oh fuck that's just Roadhog's hook”)(or path’s zipline if you attach it to an enemy)

at bay / bushed away / bush back

pushes enemies back a small distance (like 2-5M) for a small amount of damage, pretty much a punch at a distance(might rework this because the image of it funny as hell to me)

patched up

something something health

power plant

something something shields

names without abilities

bark's bite

rough patch

plot twist 

thyme crunch

party thyme

hem locked

feeling vine

log in/out

I’m already dead set on his passive being called “Upsy Daisy” which, revives allies in a quicker time and gives them a small bonus of health

He was supposed to be named Catalyst because his ult relied on vials of catalyzing agents (technically they can also be called an enzyme). He holds out his bowl and you can choose to heal or harm and throw a distance (either the L or R button). Sort of like Moira? Only it doesn’t bounce around and is grounded, lasting for... 8-10 seconds? Not sure if that is a fair amount of time.

I remember when the dev’s were testing out abilities with the Dummy’s Day Out event. They had an ability that allowed an immediate heal for a certain radius. Problem with that included you being the center of the heal, and it also healing enemies (from this event, they fixed Mirage’s ult into ‘dance party’. remember seeing 6 mirages standing in a field? good times).

If you think it takes too much time, think of Newcastle’s, Path’s or Ash’s ults. You need to aim those strategically and can’t immediately spam throw them down without tact like you can with Lifeline’s, Caustic’s or Horizon’s. I mean you can, but it might not be as accurate if you want to plan things out.

The ult still needs a name though. Hm.. Vile vial? The plant’s named Captain Fuzzy Britches... Fuzzing around? It’s based on oleander (appearance), venus fly and guarana (as a mouth and center), lotus flowers (roots), and vine snakes (body). As well as a made up plant called “whistler reeds” (typha sibilus aurae) to explain the noises it makes. It sounds like when you blow through a leaf or grass to whistle. So like a chimera. I wanted to add more animal genes, but too much and it’ll be obvious. Nature’s course?

[tintreach-cleite]

They definitely need to take a chill pill, however their point isn't entirely wrong. Aging is more like how a car works beautifully when you first get it, but without proper maintenance, it breaks down over time. For instance, if you get a brand new car model and you run it nonstop for twenty years (whilst constantly supplying gas, oil, etc.), the parts will degrade over time until they eventually stop working, no matter how much you try. However, you can halt or slow this process by maintaining it. Still doesn't matter in the grand scheme of things because no matter how much you maintain it, that's not gonna stop a drunk driver from T-boning it at seventy miles an hour and totaling it. So genetically stopping aging basically just guarantees you will die in intense pain. However, not experiencing the general pain that being old causes, this could still be seen as a plus.

scrunching my face real hard rn

[civilmentor1]

CURRENT AFFAIRS - 31 July 2024

1.CRISPR Fncas9 ● Indian scientists build breakthrough gene-editor, are aiming for patent ● A CRISPR system built to use the FnCas9 enzyme was found to editgenomes more efficiently and with less unintended damage than existingtechnologies, researchers at CSIR-IGIB and the L.V. Prasad Eye Institutehave reported ● Scientists from the CSIR-Institute of Genomics and Integrative Biology,New Delhi,…

[maisha-online]

The Essential Role of Cylicins in Sperm Development and Fertility

Sperm development, known as spermiogenesis, is a complex process involving various stages and intricate structural changes. Recent research has shed light on the crucial role of Cylicins in spermiogenesis and male fertility in both mice and humans. Cylicins, specifically Cylicin 1 (Cylc1) and Cylicin 2 (Cylc2), are essential components of the perinuclear theca (PT), a critical part of the sperm…

[deinheilpraktiker]

Wissenschaftler entwickeln Organoide menschlicher Speicheldrüsen, um die Infektiosität von SARS-CoV-2 zu testen In einer kürzlich in der Zeitschrift veröffentlichten Studie NaturzellbiologieForscher zeigten in vitro mithilfe eines organoiden Kulturmodells die Anfälligkeit der Speicheldrüsen für eine schwere Infektion mit dem akuten respiratorischen Syndrom Coronavirus-2 (SARS-CoV-2). Lernen: Vom Menschen induzierte pluripotente, aus Stammzellen gewonnene Speicheldrüsenorganoide modellieren die SARS-CoV-2-Infektion und -Replikation. Bildnachweis: NIAID Hintergrund Obwohl das At... #ACE2 #Agonist #Angiotensin #Angiotensin_Converting_Enzym_2 #Atemwege #B_Zelle #Cas9 #Coronavirus #Coronavirus_Krankheit_COVID_19 #CRISPR #EIWEISS #Enzym #Fibroblast #Gen #Genbearbeitung #gene #Genexpression #Genomik #Gewebekultur #in_vivo #in_vitro #Induzierte_pluripotente_Stammzellen #Intrazellulär #Kalzium #Lunge #Mesenchym #Organoide #Palindromische_Wiederholungen #Phänotyp #Radfahren #Rezeptor #Ribonukleinsäure #SARS #SARS_CoV_2 #Schwere_akute_Atemwegserkrankungen #Schweres_akutes_respiratorisches_Syndrom #Serin #Speicheldrüse #Stammzellen #Syndrom #Test #Transkription #Vorläuferzellen #Wachstumsfaktor #Zelle #Zellen_Biologie

[bpod-bpod]

Formin Shapes

The role of proteins called formins – key to the assembly of cells' inner scaffold or cytoskeleton – in the mechanics of migration of highly adherent cells is revealed by inactivating certain formins by CRISPR-Cas9 technology

Read the published research article here

Video from work by Jonas Scholz, Till Stephan, Aina Gallemí and Agnes Csiszár, and colleagues

Institute for Biophysical Chemistry, Hannover Medical School, Hannover, Germany

Video originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in Science Advances, October 2024

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[splicejunction]

I just have to make it to june and then I get to go to an RNA conference headlined by jen doudna (and also see all my hoes in east coast area codes)

[cyb3rbr4tzz]

"Artist genes" and the belonging enzymes have been created using the above mentiond tools and inserted into Lieuwe van Gogh's genome in order to elevate natural dispositions of creativity.

Sugababe, 2014-2021

by diemut strebe

replica of Vincent van Gogh’s ear, via mtDNA genome of great-great-great grandchild of Vincent’s mother

living genetically engineered, reprogrammed and immortalized chondrocytes seeded on a biodegradable scaffold, plasma, acrylic containers, pumpsystem, microphone, speakers

[cbirt]

The UK has achieved a historic milestone by becoming the first country to authorize a revolutionary new treatment for two serious inherited blood conditions – sickle cell disease and beta-thalassemia. The cutting-edge therapy utilizes CRISPR gene editing technology to precisely correct errors in patients’ blood stem cells, potentially curing them of debilitating symptoms.

Announced earlier this week, the treatment called Casgevy (exagamglogene autotemcel) has been approved for use by the Medicines and Healthcare Products Regulatory Agency (MHRA). This landmark decision opens the door for this powerful gene editing approach to start benefiting eligible patients after final assessments by the National Institute for Health and Care Excellence (NICE).

Casgevy targets two blood disorders sharing an underlying mutation that reduces normal hemoglobin levels. Sickle cell disease distorts red blood cells into inflexible sickled shapes, causing severe pain, organ damage, and shortened lifespan. An estimated 15,000 people in the UK live with this painful condition.

Continue Reading

[science-sculpt]

CRISPR-Cas9: A Gene-Editing Revolution

Imagine wielding a microscopic scalpel, sharp enough to snip and edit the very blueprint of life itself. Sounds like science fiction, right? Not anymore! CRISPR-Cas9, a name that has become synonymous with scientific breakthroughs, holds immense potential to revolutionize various fields, from medicine to agriculture. But what exactly is this technology, and how does it work? Let's delve into the world of CRISPR-Cas9, unraveling its complexities and exploring its exciting possibilities.

The story begins not in a gleaming lab, but in the humble world of bacteria. These tiny organisms possess a unique immune system that utilizes CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) sequences and Cas9 protein. When a virus attacks, the bacteria capture snippets of viral DNA and store them as CRISPR arrays. The Cas9 protein, guided by these arrays, then snips the matching viral DNA, rendering the virus harmless.

Scientists, inspired by this natural marvel, realized they could harness the power of CRISPR-Cas9 for their own purposes. By tweaking the guide RNA (the mugshot), they could target specific locations in any genome, not just viral DNA. This opened a new era of genome editing, allowing researchers to add, remove, or alter genes with unprecedented precision.

CRISPR-Cas9 holds immense promise for various fields:

Medicine: Gene therapies for diseases like cancer, sickle cell anemia, and Alzheimer's are being explored.

Agriculture: Crops resistant to pests, diseases, and climate change are being developed.

Biotechnology: New materials, biofuels, and even xenotransplantation (animal-to-human organ transplants) are potential applications.

As with any powerful technology, CRISPR-Cas9 raises ethical concerns. Modifying the human germline (sperm and egg cells) could have unintended consequences for future generations, and editing embryos requires careful consideration and societal dialogue.

So, is CRISPR-Cas9 the key to unlocking a genetically modified future? The answer is as complex as the human genome itself. But one thing's for sure, this revolutionary tool is rewriting the rules of biology, and the plot is just getting started. CRISPR-Cas9 is still in its early stages, but its potential is immense. As we continue to refine the technology and address ethical concerns, it has the power to revolutionize various fields and improve our lives in countless ways. However, responsible development and open discussion are crucial to ensure this powerful tool benefits humanity without unintended consequences.

[onelmentarytalk]

Avances del CRISPR Cas9 y su Potencial en la Lucha Contra el Cáncer : La cura está en las manos de la edición genética

Exponencial desarrollo en la Edición Genética: El CRISPR Cas9 y su Impacto en la Medicina del Futuro En las últimas décadas, la ciencia y la tecnología han experimentado un progreso sin precedentes, llevando a descubrimientos y desarrollos que una vez parecían pertenecer solo al ámbito de la ciencia ficción. Uno de los avances más revolucionarios en este campo es la tecnología de edición…

[deinheilpraktiker]

Bahnbrechende Gene-Editing-Technik kann fehlerhafte T-Zellen bei Patienten mit CTLA-4-Insuffizienz reparieren Ein Fehler in Zellen, die einen Schlüsselteil des Immunsystems bilden, kann mit einer bahnbrechenden Gen-Editing-Technik repariert werden, wie neue Forschungsergebnisse unter der Leitung von UCL-Wissenschaftlern an menschlichen Zellen und Mäusen zeigen. Forscher sagen, dass die in Science Translational Medicine veröffentlichte Studie zu neuen Behandlungen für eine seltene Krankheit der weißen Blutkörperchen führen könnte, die normalerweise dazu beitragen, das Immunsys... #Autoimmunität #B_Zelle #Bakterien #BLUT #Bluterkrankung #BLUTKREBS #Cas9 #Chemotherapie #CTLA_4 #DNS #EIWEISS #Forschung #Gen #gene #Genetisch #Genexpression #Gentherapie #Gesundheit_des_Kindes #Immunität #Immunologie #Immunsystem #Intron #Kinder #Knochen #Knochenmark #Knochenmarktransplantation #Krankenhaus #Krebs #KRISPR #Medizin #OKT #Seltene_Krankheit #Stammzellen #Technologie #Transplantation #Virus #Zelle

[askpokeeosin]

Genetic modification has been tossed around for so long, but I do remember one thing in particular that stuck with me: Crispr Cas9. But on another note, how does magic work? Is it just another state of energy? Maybe it's actually physical matter? Or perhaps it's someplace on the electromagnetic spectrum? Or maybe something... more? I've got to know.

On Editing Genes Part 2/2

Fascinating new developments (and ethical problems paired with said developments) every day! The bit about mosquitoes and malaria can be read up about here in this open access article. Hopefully, my explanation wasn't horrifically wrong. If so, mea culpa.

Hopefully, I'll be able to get to an explanation about how magic works soon!

[bpod-bpod]

Editing the Future

Jennifer Doudna – born on this day (19th February)– shared the 2020 Nobel Prize for Chemistry with Emmanuelle Charpentier for developing a genetic engineering technique called CRISPR-Cas9. Based on a naturally occurring defence system used by bacteria to expunge foreign DNA from their genome, CRISPR-Cas9 has revolutionised both biomedical and plant research readily revealing the impact of editing genes in living cells and model organisms, and is being applied in human genome editing to correct disease-causing gene faults and deliver gene therapies

Image by Christopher Michel, on Flickr

Image originally published with a Creative Commons Attribution 2.0 Generic (CC BY 2.0)

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