#cancer stem cell

[bpod-bpod]

Getting the Message

A study of cell proliferation in liver regeneration reveals a form of cell to cell communication involving vesicles – dubbed intercellsomes – bearing the stem cell and cancer stem cell marker CD133

Read the published research paper here

Image from work by Kota Kaneko and colleagues

Department of Pathology, Department of Molecular Biology, and Moores Cancer Center, University of California at San Diego, La Jolla, CA, USA

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in eLife, August 2023

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[venomgender]

3 months ago almost to this day we were told my cousins cancer was so bad she could pass at any moment and would need a miracle to survive... today shes stable celebrating her birthday.... it just feels really good

[rodspurethoughts]

FDA Approves Omisirge, a Cell Therapy for Blood Cancer Patients Undergoing Stem Cell Transplantation

The FDA has recently approved a cell therapy called Omisirge (omidubicel-onlv) for patients with blood cancers who are undergoing stem cell transplantation. This allogeneic cord blood-based cell therapy can help speed up the recovery of neutrophils in the body, a type of white blood cell, and reduce the risk of infection. Omisirge is intended for use in adults and pediatric patients 12 years and…

[beakers-and-telescopes]

What is Cancer, Actually?

Ever since covid there has obviously been a huge spike in people distrusting the medical community- with everything. I've started to hear the argument, "oh, they don't want to cure cancer because they make so much money treating it!", which is stupid, but it's a lot easier to refute when you actually know what happens in your body when you have cancer. So what is cancer, actually?

In short, cancer is what happens when some of your cells mutate in a way that makes them grow uncontrollably. Normally, your cells receive signals telling them to grow and divide. The more times they divide, the greater the chance that they'll pick up mutations along the way. If the cells get too old or too damaged, however, they are equipped with a "kill switch" that triggers apoptosis, or programmed cell death. This does a pretty good job at removing damaged cells from your body. However, sometimes a cell will mutate in a way that it keeps growing regardless of what the signals are telling it, and loses its ability for apoptosis. When this happens, the cells will divide rapidly to form lumps of tissue called tumors. These can be benign in some cases, but in others they can be deadly. All that the cancer cells in the tumor care about is multiplying, no matter the cost. They may destroy healthy cells that get in their way, block the supply of nutrients or oxygen, or allow waste products to build up. They may even spread to other parts of the body, where they can continue to cause damage.

So if we know how cancer works, why haven't we cured it yet?

Cancer is not a single disease- it's an umbrella term for over 200 different conditions. And even though they all stem from the uncontrolled growth of cells, they are incredibly diverse, and often respond differently to different sorts of treatment.

In order to get rid of the cancer we need to kill the cancer cells. But since the cancer cells are just normal cells that got mutated, most ways of doing so will also damage the rest of your cells. Chemotherapy often works because it kills the fast-dividing cancer cells faster than it kills the rest of you (side note: common chemo side effects such as hair loss and nausea are due to the fact that the cells that your hair grows from and the cells of your stomach lining are also very fast-dividing, meaning that they often get harmed by the radiation as well). This doesn't work for all cancers, however, and for those we would need a way to kill the cancer cells that is either less harmful to the normal cells or targets only the cancerous cells. But that is very difficult to do, because...

There is not one single mutation that turns a normal cell into a cancer cell. the pathways that a cell can take into becoming cancer are endless, so treatments that work for cancer cells with a certain set of mutation might be entirely ineffective for others.

Because cancer cells divide so quickly and don't undergo apoptosis when they are damaged, the rate at which they can pick up new mutations dramatically increases. This means that they can change in a number of unpredictable ways, such as becoming resistant to treatments or learning to survive in different areas of the body.

So while these factors make it unlikely that cancer will be "cured" in the near future, people are constantly researching to discover new and more effective methods of treatment such as CAR T therapies. No doubt we will continue to see more and more progress as time goes on.

[ravings-of-a-mad-scientist]

The Real Reason Why We Can't Cure Cancer: Cancer Stem Cells

The Real Reason Why We Can’t Cure Cancer: Cancer Stem Cells

Y’know cancer? It’s basically communism for your cells. Your cells work away their entire lives just so the sperm/egg bourgeoisie can do nothing but laze around all day and maybe have sex. But do the proletariat ever get to taste the fruits of their own labor and pass on their genes to the next generation? No. They die when you die.  But then Oncovirus Marx publishes the Cancerist Manifesto…

[cyclicallife]

Over the past few months, various events or things have triggered me.

Some are minuscule, such as a sound or smell that will set off several memories. Others are more significant, a bodily sensation, an ache, cough, or the like that provokes a more powerful emotional/psychological response.

I note these reactions, a tactic I use to help ground myself. From there, I can move forward, understanding more about it (the trigger) and my relationship with it. If I can, witnessing myself is the trick; detecting what is occurring before being consumed.

The milestone of the five-year cancer-free mark is not an exemption from fear and worry. Sometimes they peak at the same level they did while amid treatment -- periodically even more so.

Nights are difficult. Anyone who has experienced a tumultuous and life-altering event can attest that this is when the little dark fears come out of the woodwork.

A few weeks ago, I returned from Samsø, Denmark (see the previous update here or blog post on cyclical.life). A small island with under 4,000 inhabitants, nestled snuggly off the Jutland peninsula. Though it has several adorable little towns, the 40-something square mile island is used primarily for agricultural purposes. To say that it is a walkers' paradise is an understatement.

When I am state-side, I often sit with these "little dark fears" only to a certain point. It wasn't a bold pursuit or some other brave endeavor that granted me the time and pace to do so on Samsø; it happened as if on its own.

One night, awoken by worries and fears, I got dressed, grabbed my raincoat, and went for a walk. It was almost a knee-jerk reaction. As I joked to a few people, the beautiful thing about an island is that you can't get lost; you ramble through fields and upon well-worn tractor paths, and sooner or later, you'll encounter the ocean.

Every evening I filled my rucksack with: a rainjacket, another base layer, extra socks, a flashlight, a field recorder, and bread, butter, and honey, just in case. Then, I'd begin walking if I woke in the night, regardless of the time and conditions, to discover that the fears were present.  

State-side, if my worries and fears become too great, and my audiobook or music doesn't cut through the mix, I'll bust out trusty ol' Netflix. I didn't have such distractions there. Though I purchased a Danish SIM card for emergencies, I didn't carry my phone or bring my pre-downloaded audiobook.

Bringing the field recorder was the best decision. I didn't intend to record myself, but I'd sit on some slight rise or the beach and try to collect my thoughts and gather my ideas while talking aloud - a practice I began while in school as it helped me work out ideas. My words were wandering much in the way I was rambling physically.

I have a project in mind for the recordings. Though what follows are some excerpts and snippets I pulled that I found revealing.

*

I move forward in this place (of recovery)

A beacon pulling / a signal drawing

Being held - here

I have learned to live with the memory of you [cancer], as one does with something that echoed, a thing that came.

The lights of Aarhus could be another world - a gentle glow (western paling sky). Aarhus could be Boston from here - Mass General could be anywhere. I could be anywhere. I am here.

Birds; two, then three, then 4, and 5 (a dance that says 'we are together in this; we heal together.')

[kanakamfoundation]

[bpod-bpod]

Targets in Practice

Executing a slick move on the training pitch is one thing, but doing it during a big match is another. And getting treatments working in lab experiments doesn’t mean they’ll be effective in the body. Researchers know that γδ T cells (a type of immune cell, green) have the potential to fight cancer (blue), pinpointing tumour cells that produce stress-induced signals. Triple-negative breast cancer, however, employs a pool of cancer stem cells to evade these immune cells. In lab tests, T cells from healthy donors were able to target these stem cells, but when the researchers repeated the test in mice it was as if they vanished into the crowd, rendering the γδ T cells ineffective. Treating the mice with zoledronate – a drug already used to treat osteoporosis – helped the T cells lock onto the cancer cells, suggesting new combination immunotherapy approaches for the hard-to-treat triple negative breast cancer.

Written by Anthony Lewis

Image from work by Katrin Raute and colleagues

Faculty of Biology, University of Freiburg, Freiburg, Germany

Image copyright held by the original authors

Research published in Cancer Immunology Research, May 2023

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[yourfavoritehouseplant]

>find a post of someone deriding a new technological development because 'its AI' >ask the poster whether its generative AI or literally any other type of machine learning >they don't understand | I pull out illustrated diagram explaining what is and isn't generative AI >they frown and say "It's AI" >i look up what they're complaining about >they found new Nazca Lines?????

[gomediitechnologies]

Stem Cell Transplant in India - GoMedii

Explore stem cell transplant options at GoMedii, where cutting-edge therapies are offered for various conditions, including blood disorders and cancers. Our expert team provides comprehensive care and support throughout the transplant process to enhance recovery and improve outcomes.

[tofiqbohra11]

https://speakerdeck.com/urbanphulkari06/maxillofacial-surgery-for-accident-recovery-what-you-need-to-know

[techtoio]

Biotech Breakthroughs: Cutting-Edge Innovations That Will Change Health Care

Introduction

The field of biotechnology is at the forefront of some of the most groundbreaking advancements in healthcare. With new discoveries and innovations emerging at an unprecedented rate, biotech is poised to transform the way we approach health care. From revolutionary treatments to personalized medicine, the potential of biotech to improve lives is immense. In this article, we’ll delve into the most significant biotech breakthroughs and how they are set to change health care as we know it. Read to continue

[kanakamfoundation]

Kanakam Foundation, it is a non-profit organisation, it focus on blood stem cells donation, research and support.

Our new initiatives is Register new donors, support patients, conduct awareness campaigns and collaborate with healthcare institutions.

#joining Hands to Beat Blood Cancer#

In a world where compassion meets action, the Kanakam Foundation has been a beacon of hope since 2016, offering life-changing support to the underprivileged. Join us in our mission to fight blood cancer through groundbreaking Stem Cell Therapy and provide nourishment to families and caregivers of cancer patients. What We Do: 💉 Free Blood Stem Cell Storage and Donation for the needy 🍽 Mid-Day Meal Donation Program for cancer patient attendees 🎓 Empowering women with MSc PG Diploma Courses in Oncology Nursing Our dedicated team and volunteers work tirelessly to provide comfort and care, ensuring that no one fights cancer alone. Whether it's through life-saving stem cell donations or nourishing meals for caregivers, we're here every step of the way. Join us today, volunteer, or donate—let’s make a difference together. 💪💖 🔗 Discover more about how you can be part of this journey. Visit Kanakam Foundation and let’s shine a light in the fight against cancer! ✨ #KanakamFoundation#StemCellTherapy#BloodCancer#Volunteer#NourishmentSupport#EmpoweringWomen#CancerCare#DonateNow#FightAgainstCancer#OncologyNursing