#cancer stem cell

[bpod-bpod]

Getting the Message

A study of cell proliferation in liver regeneration reveals a form of cell to cell communication involving vesicles – dubbed intercellsomes – bearing the stem cell and cancer stem cell marker CD133

Read the published research paper here

Image from work by Kota Kaneko and colleagues

Department of Pathology, Department of Molecular Biology, and Moores Cancer Center, University of California at San Diego, La Jolla, CA, USA

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in eLife, August 2023

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[venomgender]

3 months ago almost to this day we were told my cousins cancer was so bad she could pass at any moment and would need a miracle to survive... today shes stable celebrating her birthday.... it just feels really good

[rodspurethoughts]

FDA Approves Omisirge, a Cell Therapy for Blood Cancer Patients Undergoing Stem Cell Transplantation

The FDA has recently approved a cell therapy called Omisirge (omidubicel-onlv) for patients with blood cancers who are undergoing stem cell transplantation. This allogeneic cord blood-based cell therapy can help speed up the recovery of neutrophils in the body, a type of white blood cell, and reduce the risk of infection. Omisirge is intended for use in adults and pediatric patients 12 years and…

[beakers-and-telescopes]

What is Cancer, Actually?

Ever since covid there has obviously been a huge spike in people distrusting the medical community- with everything. I've started to hear the argument, "oh, they don't want to cure cancer because they make so much money treating it!", which is stupid, but it's a lot easier to refute when you actually know what happens in your body when you have cancer. So what is cancer, actually?

In short, cancer is what happens when some of your cells mutate in a way that makes them grow uncontrollably. Normally, your cells receive signals telling them to grow and divide. The more times they divide, the greater the chance that they'll pick up mutations along the way. If the cells get too old or too damaged, however, they are equipped with a "kill switch" that triggers apoptosis, or programmed cell death. This does a pretty good job at removing damaged cells from your body. However, sometimes a cell will mutate in a way that it keeps growing regardless of what the signals are telling it, and loses its ability for apoptosis. When this happens, the cells will divide rapidly to form lumps of tissue called tumors. These can be benign in some cases, but in others they can be deadly. All that the cancer cells in the tumor care about is multiplying, no matter the cost. They may destroy healthy cells that get in their way, block the supply of nutrients or oxygen, or allow waste products to build up. They may even spread to other parts of the body, where they can continue to cause damage.

So if we know how cancer works, why haven't we cured it yet?

Cancer is not a single disease- it's an umbrella term for over 200 different conditions. And even though they all stem from the uncontrolled growth of cells, they are incredibly diverse, and often respond differently to different sorts of treatment.

In order to get rid of the cancer we need to kill the cancer cells. But since the cancer cells are just normal cells that got mutated, most ways of doing so will also damage the rest of your cells. Chemotherapy often works because it kills the fast-dividing cancer cells faster than it kills the rest of you (side note: common chemo side effects such as hair loss and nausea are due to the fact that the cells that your hair grows from and the cells of your stomach lining are also very fast-dividing, meaning that they often get harmed by the radiation as well). This doesn't work for all cancers, however, and for those we would need a way to kill the cancer cells that is either less harmful to the normal cells or targets only the cancerous cells. But that is very difficult to do, because...

There is not one single mutation that turns a normal cell into a cancer cell. the pathways that a cell can take into becoming cancer are endless, so treatments that work for cancer cells with a certain set of mutation might be entirely ineffective for others.

Because cancer cells divide so quickly and don't undergo apoptosis when they are damaged, the rate at which they can pick up new mutations dramatically increases. This means that they can change in a number of unpredictable ways, such as becoming resistant to treatments or learning to survive in different areas of the body.

So while these factors make it unlikely that cancer will be "cured" in the near future, people are constantly researching to discover new and more effective methods of treatment such as CAR T therapies. No doubt we will continue to see more and more progress as time goes on.

[linstudy]

December 17, 2024 | fried eggs mixed in my cell culture

ooh boy… where should I start? i f*cked up. yep. mycoplasma contamination is the worst. my only consolation is that these are my *practice* cells, not the real ones i should use for my thesis. i reported to my supervisor and waiting for a feedback. anyone has any advice?

[hersheysmcboom]

Please help save his life, become a donor today

[kanakamfoundation]

[bpod-bpod]

Targets in Practice

Executing a slick move on the training pitch is one thing, but doing it during a big match is another. And getting treatments working in lab experiments doesn’t mean they’ll be effective in the body. Researchers know that γδ T cells (a type of immune cell, green) have the potential to fight cancer (blue), pinpointing tumour cells that produce stress-induced signals. Triple-negative breast cancer, however, employs a pool of cancer stem cells to evade these immune cells. In lab tests, T cells from healthy donors were able to target these stem cells, but when the researchers repeated the test in mice it was as if they vanished into the crowd, rendering the γδ T cells ineffective. Treating the mice with zoledronate – a drug already used to treat osteoporosis – helped the T cells lock onto the cancer cells, suggesting new combination immunotherapy approaches for the hard-to-treat triple negative breast cancer.

Written by Anthony Lewis

Image from work by Katrin Raute and colleagues

Faculty of Biology, University of Freiburg, Freiburg, Germany

Image copyright held by the original authors

Research published in Cancer Immunology Research, May 2023

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[yourfavoritehouseplant]

>find a post of someone deriding a new technological development because 'its AI' >ask the poster whether its generative AI or literally any other type of machine learning >they don't understand | I pull out illustrated diagram explaining what is and isn't generative AI >they frown and say "It's AI" >i look up what they're complaining about >they found new Nazca Lines?????

[gomediitechnologies]

Stem Cell Transplant in India - GoMedii

Explore stem cell transplant options at GoMedii, where cutting-edge therapies are offered for various conditions, including blood disorders and cancers. Our expert team provides comprehensive care and support throughout the transplant process to enhance recovery and improve outcomes.

[tofiqbohra11]

https://speakerdeck.com/urbanphulkari06/maxillofacial-surgery-for-accident-recovery-what-you-need-to-know

[techtoio]

Biotech Breakthroughs: Cutting-Edge Innovations That Will Change Health Care

Introduction

The field of biotechnology is at the forefront of some of the most groundbreaking advancements in healthcare. With new discoveries and innovations emerging at an unprecedented rate, biotech is poised to transform the way we approach health care. From revolutionary treatments to personalized medicine, the potential of biotech to improve lives is immense. In this article, we’ll delve into the most significant biotech breakthroughs and how they are set to change health care as we know it. Read to continue

[kanakamfoundation]

Kanakam Foundation, it is a non-profit organisation, it focus on blood stem cells donation, research and support.

Our new initiatives is Register new donors, support patients, conduct awareness campaigns and collaborate with healthcare institutions.

#joining Hands to Beat Blood Cancer#

In a world where compassion meets action, the Kanakam Foundation has been a beacon of hope since 2016, offering life-changing support to the underprivileged. Join us in our mission to fight blood cancer through groundbreaking Stem Cell Therapy and provide nourishment to families and caregivers of cancer patients. What We Do: 💉 Free Blood Stem Cell Storage and Donation for the needy 🍽 Mid-Day Meal Donation Program for cancer patient attendees 🎓 Empowering women with MSc PG Diploma Courses in Oncology Nursing Our dedicated team and volunteers work tirelessly to provide comfort and care, ensuring that no one fights cancer alone. Whether it's through life-saving stem cell donations or nourishing meals for caregivers, we're here every step of the way. Join us today, volunteer, or donate—let’s make a difference together. 💪💖 🔗 Discover more about how you can be part of this journey. Visit Kanakam Foundation and let’s shine a light in the fight against cancer! ✨ #KanakamFoundation#StemCellTherapy#BloodCancer#Volunteer#NourishmentSupport#EmpoweringWomen#CancerCare#DonateNow#FightAgainstCancer#OncologyNursing