#cell therapy

[tha-wrecka-stow]

You Can Find The Original Version -> Here

[jcmarchi]

Unlocking mRNA’s cancer-fighting potential

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Unlocking mRNA’s cancer-fighting potential

What if training your immune system to attack cancer cells was as easy as training it to fight Covid-19? Many people believe the technology behind some Covid-19 vaccines, messenger RNA, holds great promise for stimulating immune responses to cancer.

But using messenger RNA, or mRNA, to get the immune system to mount a prolonged and aggressive attack on cancer cells — while leaving healthy cells alone — has been a major challenge.

The MIT spinout Strand Therapeutics is attempting to solve that problem with an advanced class of mRNA molecules that are designed to sense what type of cells they encounter in the body and to express therapeutic proteins only once they have entered diseased cells.

“It’s about finding ways to deal with the signal-to-noise ratio, the signal being expression in the target tissue and the noise being expression in the nontarget tissue,” Strand CEO Jacob Becraft PhD ’19 explains. “Our technology amplifies the signal to express more proteins for longer while at the same time effectively eliminating the mRNA’s off-target expression.”

Strand is set to begin its first clinical trial in April, which is testing a proprietary, self-replicating mRNA molecule’s ability to express immune signals directly from a tumor, eliciting the immune system to attack and kill the tumor cells directly. It’s also being tested as a possible improvement for existing treatments to a number of solid tumors.

As they work to commercialize its early innovations, Strand’s team is continuing to add capabilities to what it calls its “programmable medicines,” improving mRNA molecules’ ability to sense their environment and generate potent, targeted responses where they’re needed most.

“Self-replicating mRNA was the first thing that we pioneered when we were at MIT and in the first couple years at Strand,” Becraft says. “Now we’ve also moved into approaches like circular mRNAs, which allow each molecule of mRNA to express more of a protein for longer, potentially for weeks at a time. And the bigger our cell-type specific datasets become, the better we are at differentiating cell types, which makes these molecules so targeted we can have a higher level of safety at higher doses and create stronger treatments.”

Making mRNA smarter

Becraft got his first taste of MIT as an undergraduate at the University of Illinois when he secured a summer internship in the lab of MIT Institute Professor Bob Langer.

“That’s where I learned how lab research could be translated into spinout companies,” Becraft recalls.

The experience left enough of an impression on Becraft that he returned to MIT the next fall to earn his PhD, where he worked in the Synthetic Biology Center under professor of bioengineering and electrical engineering and computer science Ron Weiss. During that time, he collaborated with postdoc Tasuku Kitada to create genetic “switches” that could control protein expression in cells.

Becraft and Kitada realized their research could be the foundation of a company around 2017 and started spending time in the Martin Trust Center for MIT Entrepreneurship. They also received support from MIT Sandbox and eventually worked with the Technology Licensing Office to establish Strand’s early intellectual property.

“We started by asking, where is the highest unmet need that also allows us to prove out the thesis of this technology? And where will this approach have therapeutic relevance that is a quantum leap forward from what anyone else is doing?” Becraft says. “The first place we looked was oncology.”

People have been working on cancer immunotherapy, which turns a patient’s immune system against cancer cells, for decades. Scientists in the field have developed drugs that produce some remarkable results in patients with aggressive, late-stage cancers. But most next-generation cancer immunotherapies are based on recombinant (lab-made) proteins that are difficult to deliver to specific targets in the body and don’t remain active for long enough to consistently create a durable response.

More recently, companies like Moderna, whose founders also include MIT alumni, have pioneered the use of mRNAs to create proteins in cells. But to date, those mRNA molecules have not been able to change behavior based on the type of cells they enter, and don’t last for very long in the body.

“If you’re trying to engage the immune system with a tumor cell, the mRNA needs to be expressing from the tumor cell itself, and it needs to be expressing over a long period of time,” Becraft says. “Those challenges are hard to overcome with the first generation of mRNA technologies.”

Strand has developed what it calls the world’s first mRNA programming language that allows the company to specify the tissues its mRNAs express proteins in.

“We built a database that says, ‘Here are all of the different cells that the mRNA could be delivered to, and here are all of their microRNA signatures,’ and then we use computational tools and machine learning to differentiate the cells,” Becraft explains. “For instance, I need to make sure that the messenger RNA turns off when it’s in the liver cell, and I need to make sure that it turns on when it’s in a tumor cell or a T-cell.”

Strand also uses techniques like mRNA self-replication to create more durable protein expression and immune responses.

“The first versions of mRNA therapeutics, like the Covid-19 vaccines, just recapitulate how our body’s natural mRNAs work,” Becraft explains. “Natural mRNAs last for a few days, maybe less, and they express a single protein. They have no context-dependent actions. That means wherever the mRNA is delivered, it’s only going to express a molecule for a short period of time. That’s perfect for a vaccine, but it’s much more limiting when you want to create a protein that’s actually engaging in a biological process, like activating an immune response against a tumor that could take many days or weeks.”

Technology with broad potential

Strand’s first clinical trial is targeting solid tumors like melanoma and triple-negative breast cancer. The company is also actively developing mRNA therapies that could be used to treat blood cancers.

“We’ll be expanding into new areas as we continue to de-risk the translation of the science and create new technologies,” Becraft says.

Strand plans to partner with large pharmaceutical companies as well as investors to continue developing drugs. Further down the line, the founders believe future versions of its mRNA therapies could be used to treat a broad range of diseases.

“Our thesis is: amplified expression in specific, programmed target cells for long periods of time,” Becraft says. “That approach can be utilized for [immunotherapies like] CAR T-cell therapy, both in oncology and autoimmune conditions. There are also many diseases that require cell-type specific delivery and expression of proteins in treatment, everything from kidney disease to types of liver disease. We can envision our technology being used for all of that.”

[rodspurethoughts]

FDA Approves Omisirge, a Cell Therapy for Blood Cancer Patients Undergoing Stem Cell Transplantation

The FDA has recently approved a cell therapy called Omisirge (omidubicel-onlv) for patients with blood cancers who are undergoing stem cell transplantation. This allogeneic cord blood-based cell therapy can help speed up the recovery of neutrophils in the body, a type of white blood cell, and reduce the risk of infection. Omisirge is intended for use in adults and pediatric patients 12 years and…

[health-views-updates]

Cell Therapy Market Report: Size, Growth, and Key Trends to 2032

The Cell Therapy Market Revenue was valued at USD 4.65 billion in 2023 and is expected to reach an impressive USD 28.98 billion by 2032, growing at a staggering CAGR of 22.55% over the forecast period 2024-2032. This robust growth is fueled by advancements in regenerative medicine, increasing prevalence of chronic diseases, and the rising demand for personalized treatment solutions.

Key Drivers of Growth

The cell therapy market is experiencing unprecedented expansion driven by breakthroughs in research and development (R&D) and the rising number of clinical trials exploring the therapeutic potential of cellular therapies. These therapies, which include stem cell and CAR-T cell treatments, are proving to be transformative in addressing a wide range of medical conditions, including cancer, autoimmune diseases, and genetic disorders.

Moreover, regulatory agencies worldwide are increasingly supporting the development and approval of innovative cell-based therapies. The accelerated approval pathways and favorable reimbursement policies in key regions are fostering the adoption of cell therapy in mainstream healthcare. The convergence of advanced technologies, such as CRISPR gene editing, with cell therapy is further propelling the market toward significant innovation.

Regional Insights

North America continues to lead the market due to its robust healthcare infrastructure, substantial investment in R&D, and the presence of major biopharmaceutical companies. Meanwhile, the Asia-Pacific region is emerging as a high-growth market, driven by government initiatives to promote biotechnology, increasing healthcare expenditures, and a growing focus on addressing unmet medical needs.

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Future Outlook

The cell therapy market is expected to experience exponential growth as technological advancements and increasing awareness of these therapies' potential reshape the treatment landscape. The integration of artificial intelligence (AI) and data analytics in cell therapy research is expected to enhance precision and accelerate drug development processes. Furthermore, collaborative efforts between academia, healthcare providers, and industry players will likely contribute to faster adoption and commercialization of innovative solutions.

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[painandhealingwellnesscenter]

Nerve damage, often caused by injury, disease, or aging, can significantly affect daily life. Symptoms like chronic pain, tingling, and numbness make routine activities challenging. Traditional treatments often rely on pain management or surgery, but regenerative medicine offers a non-invasive alternative that actively promotes healing. Using techniques like Platelet-Rich Plasma (PRP) and stem cell therapies, regenerative medicine encourages tissue repair and nerve regeneration, helping to address the underlying issue rather than merely masking symptoms.

[healthcare-skyquest]

Cell Therapy Market: Driving Breakthroughs in Regenerative Medicine

The Cell Therapy market is gaining momentum as a cutting-edge approach in regenerative medicine, offering promising solutions for treating various diseases. With advancements in stem cell research and growing demand for innovative treatments, the cell therapy market is poised for remarkable growth. This article delves into the latest trends, market segmentation, key growth drivers, and top players in the cell therapy industry.

Market Overview

SkyQuest’s Cell Therapy Market report estimates the market value at USD 6.7 Billion in 2023, with a projected CAGR of 52%. The market is expanding due to increasing investments in stem cell research, rising prevalence of chronic diseases, and a shift towards personalized medicine.

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Market Segmentation

By Therapy Type:

Autologous Therapy: Uses the patient's own cells for treatment, minimizing the risk of rejection.

Allogeneic Therapy: Involves using donor cells, which are more accessible but may require immune suppression.

By Application:

Cancer: Cell therapies, such as CAR-T cell therapy, are revolutionizing cancer treatment by targeting and destroying cancer cells.

Autoimmune Disorders: Cell therapies are being used to modulate the immune system in conditions like multiple sclerosis and lupus.

Cardiovascular Diseases: Emerging therapies aimed at regenerating damaged heart tissues after heart attacks.

Neurological Disorders: The development of cell-based treatments for diseases like Parkinson's and spinal cord injuries.

By End-User:

Hospitals and Clinics: Primary centers for the administration of cell therapies.

Academic and Research Institutes: Pioneers in the development of new cell therapy solutions.

Biotechnology and Pharmaceutical Companies: Leading the commercialization of cell therapy products.

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Key Growth Drivers

Advancements in Stem Cell Research: Breakthroughs in stem cell technologies are enabling the development of more effective therapies.

Growing Prevalence of Chronic Diseases: The increasing burden of diseases like cancer, autoimmune disorders, and cardiovascular diseases drives the demand for cell therapies.

Increasing R&D Investment: Significant investments in cell therapy research and clinical trials are accelerating the discovery of new treatments.

Shift Towards Personalized Medicine: Personalized cell therapies are tailored to individual patients, offering more effective and targeted treatments.

Leading Companies in the Market

SkyQuest’s Cell Therapy Market report highlights the following major players:

Novartis AG

Gilead Sciences

Bristol-Myers Squibb

Celgene Corporation

JCR Pharmaceuticals Co., Ltd.

Osiris Therapeutics, Inc.

Vericel Corporation

Fate Therapeutics

Bluebird Bio

Kolon TissueGene

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Challenges and Opportunities

The cell therapy market faces challenges such as high costs, stringent regulatory requirements, and manufacturing complexities. However, these obstacles also present opportunities for companies to develop cost-effective solutions and scalable production methods.

Future Outlook

The future of the cell therapy market looks promising, with increasing clinical trials, expanding treatment applications, and growing partnerships between academic institutions and pharmaceutical companies. As the industry evolves, companies that focus on innovation and overcoming regulatory challenges will thrive.

Conclusion

The cell therapy market is at the forefront of medical innovation, offering transformative treatments for chronic and life-threatening diseases. Decision-makers in the healthcare sector should stay informed about emerging trends and developments in this rapidly growing field. For in-depth insights and strategic recommendations, consult SkyQuest’s Cell Therapy Market report.

[omshinde5145]

Primary Cells Market Trends, Review, and Forecast 2024–2030

The Primary Cells Market was valued at USD 1.6 billion in 2023 and will surpass USD 3.1 billion by 2030; growing at a CAGR of 10.0% during 2024 - 2030. Primary cells, derived directly from living tissues, maintain the physiological relevance of human biology, making them invaluable in scientific research. Unlike immortalized cell lines, primary cells retain their unique characteristics, providing more accurate models for in vitro studies. This blog explores the key trends, growth drivers, opportunities, and challenges within the primary cells market.

Key Market Trends Driving Growth

Increasing Adoption in Drug Discovery and Development Pharmaceutical companies and research institutions are leveraging primary cells for drug screening and toxicity testing. These cells offer a more accurate prediction of drug responses compared to traditional cell lines. As personalized medicine gains momentum, primary cells enable more individualized and predictive models, allowing researchers to identify specific responses to therapeutic agents.

Advancements in 3D Cell Culture and Organoid Models One of the major trends in the primary cells market is the increasing use of 3D cell culture and organoid models. These advanced culture systems more closely mimic the structure and function of human tissues, offering an enhanced platform for studying disease progression, drug efficacy, and patient-specific therapies. The integration of primary cells into these models is expected to further accelerate research in fields such as oncology, neurology, and regenerative medicine.

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Growing Demand in Cancer Research Primary cells, especially cancer-associated cells such as tumor cells or cancer-associated fibroblasts, are crucial in cancer research. With the rising incidence of cancer, there is a pressing need for more accurate in vitro models that replicate the complex tumor microenvironment. Primary cancer cells, derived directly from patient tissues, are providing researchers with the tools to develop more effective therapies and understand tumor behavior better.

Expansion of Biobanking and Cryopreservation The expansion of biobanks and cryopreservation services is another major factor contributing to the market’s growth. Primary cell biobanks offer vast repositories of cells from diverse human populations, allowing researchers to study genetic variations and disease-specific models. With the increasing emphasis on precision medicine, the demand for high-quality, well-characterized primary cells has surged, enhancing the role of biobanks in supplying these valuable resources.

Opportunities in the Primary Cells Market

Rising Interest in Regenerative Medicine Regenerative medicine is poised to transform the treatment of various degenerative diseases, and primary cells play a key role in this revolution. Stem cells, a type of primary cell, have shown tremendous potential in regenerative therapies for conditions such as heart disease, neurological disorders, and diabetes. The growing pipeline of regenerative therapies represents a lucrative opportunity for companies specializing in primary cell production and related services.

Emerging Markets and Technological Innovations Emerging markets, particularly in Asia-Pacific and Latin America, are becoming attractive for key players in the primary cells market. The increasing healthcare investments, supportive government policies, and growing focus on biotechnology research in these regions are expected to fuel demand for primary cells. Additionally, technological innovations in cell isolation, culture, and cryopreservation techniques are likely to open new avenues for growth in the market.

Partnerships and Collaborations As the complexity of cellular research increases, partnerships between academic institutions, biotech companies, and pharmaceutical firms are becoming more common. Collaborations in areas such as cell sourcing, assay development, and therapeutic applications are enhancing the capabilities of market players. These partnerships are expected to drive innovation and accelerate the adoption of primary cell-based models in various industries.

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Challenges Facing the Primary Cells Market

Limited Availability and High Costs One of the primary challenges in the market is the limited availability of certain types of primary cells, particularly those from rare or difficult-to-access tissues. The cost of isolating, culturing, and maintaining these cells can be prohibitively high, which can restrict their widespread adoption, especially in resource-constrained settings. Additionally, ethical concerns surrounding the sourcing of human tissues remain a challenge that needs to be carefully managed.

Variability and Short Lifespan Unlike immortalized cell lines, primary cells have a finite lifespan, and their characteristics can vary between donors. This variability can introduce challenges in reproducibility and consistency of experimental results, making it difficult to standardize protocols across different labs. While efforts to improve cell culture techniques and reduce variability are ongoing, this remains a significant obstacle for researchers.

Regulatory Hurdles As primary cells are increasingly used in drug development and regenerative therapies, navigating the complex regulatory landscape is becoming a key challenge. Regulatory bodies such as the FDA and EMA require stringent validation of cell-based models, which can delay the approval and commercialization of new therapies. Ensuring compliance with ethical standards for human tissue sourcing and use further complicates the regulatory process.

Conclusion

The primary cells market is poised for robust growth in the coming years, driven by advancements in personalized medicine, drug discovery, and regenerative therapies. The increasing adoption of 3D cell culture systems, expansion of biobanking, and the growing focus on cancer research are key trends shaping the market's future. However, challenges such as high costs, cell variability, and regulatory complexities must be addressed to unlock the full potential of primary cells. As technological innovations continue to emerge and collaborations expand, the primary cells market is set to play a pivotal role in the future of biomedical research and therapeutic development.

[airises]

What are induced pluripotent stem cells, and how are they different from embryonic stem cells?

What are induced pluripotent stem cells (iPSCs)? Reprogrammed adult cells: iPSCs are created in the lab by taking adult cells (often skin or blood cells) and genetically reprogramming them back to an immature, embryo-like state. Pluripotency: Like embryonic stem cells, iPSCs are pluripotent. This means they have the exceptional potential to develop into almost any type of cell in the body. Key…

[regenhealthsolutions]

A micro-fragmented collagen gel as a stem cell-assembling platform for critical limb ischemia repair

Critical limb ischemia is a condition in which the main blood vessels supplying blood to the legs are blocked, causing blood flow to gradually decrease as atherosclerosis progresses in the peripheral arteries. It is a severe form of peripheral artery disease that causes progressive closure of arteries in the lower extremity, leading to the necrosis of the leg tissue and eventual…

[tha-wrecka-stow]

You Can Find The Instrumental -> Here

[jcmarchi]

Navigating the Digital Revolution in Healthcare: A Strategic Guide for Healthcare Leaders

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Navigating the Digital Revolution in Healthcare: A Strategic Guide for Healthcare Leaders

Healthcare is witnessing an unprecedented pace of change. There are several forces at play, creating a shift in how we approach health and wellness.

First, is demographics. There is a growing gap between lifespan and healthspan. People aren’t just getting older—they’re facing different types of health challenges too. Chronic diseases and morbidities are showing up earlier in life and there is a growing focus on wellness. To cater to this changing demographics, healthcare needs to be more personalized and proactive, moving beyond just reacting to illness.

On the bright side, we’re getting better at understanding the human body and finding new ways to treat it. Healthcare technologies are evolving rapidly and care delivery is becoming more connected and collaborative thanks to digital transformation efforts and technologies like Generative AI. Game-changing innovations like CAR-T cell therapy, radioligand treatments, and advanced diagnostics (e.g., 11.7 Tesla MRI machines) are transforming how we treat and manage diseases. At the same time, device miniaturization and advancements in healthcare informatics are enabling self-management of conditions, creating new possibilities for remote patient care and monitoring.

And most importantly, given the rising cost of care, healthcare payments are now tied to value-based, outcome-oriented care rather than transactions. Payers are also stepping in to play a bigger role in managing care. This is pushing organizations to find new ways to cut costs while improving care delivery and create new outcome-based payment models.

Together, these forces are reshaping healthcare in extraordinary ways. So, in the light of these changes, what does the future look like?

The future of healthcare delivery: self-managed, connected, and boundaryless

In the light of the changes in disease mix, focus on wellness rather than treatment, and tech advancements, healthcare delivery is set to evolve in a few key ways:

Digital tiers of care: The traditional model of primary, secondary, and tertiary care is expanding to include a new “digital” tier. Digital interventions will drive connectivity, enabling remote consultations, virtual care, and better patient monitoring—making healthcare more flexible and boundaryless.

Patient-centric models: Patients, especially those with chronic conditions, will play a more active role in managing their health. This shift towards patient empowerment will reduce the reliance on hospital settings and promote continuous, proactive care.

Evolving payment models: We’ll see the right payment models emerging that emphasize value over episodic transactions and reward preventive care. These future payment frameworks will holistically focus on wellness, behavioral health, and care management rather than just individual treatments.

Coordinated patient journeys: Joining the dots in fragmented patient journeys, future care models will focus on coordination across providers, payers, and care settings. With better data sharing, patients will experience smoother, more efficient care, leading to better outcomes.

Immediate priorities for healthcare organizations

While these evolving futuristic models have a lot of potential, but to get there, healthcare organizations need to navigate some existing on ground realities—starting with finding the money for transformation, innovating at “digital native” speeds, and finding new, sustainable business models.

1. Driving down healthcare costs

We all know that healthcare costs across the system – be it care, research, or administration – are extremely high. For example, 1/7th of the total healthcare spending in the US is on administrative tasks! Every healthcare leader is asking, “How can we become a more cost-effective and efficient organization?”

The answer lies leveraging AI to reimage, optimize, and automate existing processes and operations. For example, one of the ways an AI driven predictive analytics solution can save costs is by identifying high-risk patients, suggesting and implementing targeted interventions, and reducing hospital readmissions.

 2. Embracing agility with digital transformation

To provide the best possible care and patient experience, the healthcare ecosystem needs to adopt digital technologies at scale and become more agile and collaborative. However, just implementing the latest tech is not enough. Take AI for example. We’ve seen that despite POC successes, putting AI into production at scale, ensuring it is ethically sound, accurate, and essentially flawless continues to be a challenge.

The goal for digital transformation should be to achieve true agility—not just in software development, but in how the entire organization operates. This means looking at how doctors, clinicians, payers, and patients interact, improving the speed of care delivery, and ensuring everyone is working together more effectively.

That is only possible when organizations think carefully about their strategy, prioritize use cases that can improve operations and care delivery, and seamlessly weave technology into everyday workflows.

3. Exploring new, sustainable business models

One of the biggest opportunities in digital healthcare is taking the “tribal knowledge” — the valuable insights that come from years of experience — and turning it into AI models that can be monetized. Instead of that knowledge staying locked in the minds of a few experts, it becomes something repeatable and scalable, leading to more personalized and effective care for patients.

Keeping pace with industry shifts: Strategies for healthcare leaders

If we think of an organization like a person, it has a head and a heart—intelligence and feelings. To move the needle on transformation, healthcare leaders need to balance strategy, tactics, and empathy. Successful leaders will:

Look at transformation from a dual lens: Make current operations more efficient while also creating space for new ways of working. Challenge the status quo and prepare for the transition to newer models.

Think big, start small, scale wisely: Large-scale transformations can be overwhelming. It’s important to have a big-picture vision, but the key is to start small. Experiment, test things out, and then gradually expand on what works. By proving the value of digital solutions early, you can reduce risks and build confidence as you move forward.

Embrace multimodal transformation and commit to change: Transformation isn’t just about processes—it’s about people, customers, and change orchestration. Successful change requires buy-in at all levels, from top leadership to employees on the ground. Ensure that employees can adapt to new processes and technologies as they evolve.

Find the right partner: To navigate these shifts, it’s important to find a partner who truly understands the healthcare industry and values continuous learning and innovation. For example, at CitiusTech, we work across the entire healthcare ecosystem—payers, providers, life sciences, and medtech. This gives us a unique perspective, helping our clients connect the dots and turn their big ideas into reality.

Ultimately, success in the new paradigm of healthcare will be about rethinking how healthcare services are delivered, whether through new business models or innovative  tech that can bring real benefits to patients and providers alike.

[mindfulcells]

Mira's Lymphoma Warrior Journey: Hope and CAR-T Therapy

Estimated reading time: 7 minutes The bold headlines proclaimed the promise of CAR T therapy and its efficacy in combating lymphoma’s relentless grip. Mira – a woman who had weathered the storm of cancer diagnosis, treatment, and remission. She paused to reflect on hope with her life-changing lymphoma warrior journey. As the city’s symphony of car horns echoed outside her window, she stepped…

[dontsweatthefresh]

Danny Brown - Jenn's Terrific Vacation (Official Video)

Goodie Mob - Cell Therapy (Official HD Video)

Kassa Overall: Tiny Desk Concert

[root-analysis]

TIL Cell Therapy Market CAGR | Analysis Size & Forecast (2035) 

The TIL therapy market, a part of the broader cell therapy market, is experiencing significant growth and is projected to grow at a compounded annual growth rate (CAGR) of 40% during the forecast period. The report also provides sales forecasts for TIL therapies market CAGR that are currently in the mid-to-late stages of development. Get a detailed insights report now!