#alcohol diabetes

[xcerizex]

I don't know why but seeing the character's signature drinks on the otomate garden menu is so freaking funny to me like, Sena's is just straight up black coffee which I did NOT expect. But he'd def be the type to melodramatically order coffee in goth fashion aka "Coffee as black as my soul please" kind of fashion when he's in the mood to be funny.

Also, Koyo's is just flavoured water. Water guys, it's just water. Orange flavoured yes but it's still just water.

[maddie-grove]

It is wild how many people assumed that I didn’t drink alcohol for a Serious Reason in grad school. First of all because it’s a big leap to see someone drink a Diet Coke at the bar and assume that they’re a recovering alcoholic or a traumatized child of alcoholics or opposed to alcohol for religious reasons or suffering from a medical condition that precludes drinking. Second of all because I actually did drink in grad school! I just abstained about half the time for really mundane reasons (I was broke, I had to drive, I’d recently done or said something embarrassing while drinking and didn’t want to give a repeat performance).

[clatterbane]

What's extra funny with all the hooching content lately, is that I don't actually drink that much. (Though, more than I did for years since I do have the tools to keep on top of my blood sugar now, and don't end up feeling like complete death whenever I do enjoy a couple glasses of wine anymore.)

One reason I've been sticking to small batches. Mostly just been having fun playing around with different ingredients on a hobby level, and also trying different interesting juices/other sugary things readily available in a new country--in forms less likely to fuck up my blood sugar. It's not going to taste the same with the sugar fermented out, but it's fun to see how the results do turn out.

[ajmakoko]

How is it not abuse, how is it not literally torture, for a medical doctor to deny a disabled person treatment (including diagnostic tests) for their disability or condition?

Like it's not just incompetence. It's actively weaponizing my disability against me.

I get ketoacidosis/ketosis really really easily (genetic, my sister does as well). I have had doctors accuse me of alcoholism (which I literally can't have because I also have a tyramine gene that means it's like I'm on an MAOI at all times and would literally burst a blood vessel from high blood pressure) or having an eating disorder (which is probably more accurate bc celiac, which I also have, imitates a lot of issues of anorexia since it's an absorption issue along with autoimmune). I was never screened for diabetes then even though it's common to develop diabetes if you have celiac.

High ammonia in your bloodstream from keto isn't good for your kidneys. Denying me medical treatment as a punishment because they think I'm an alcoholic or anorexic (and don't want to test for anything else) is not just extremely fucked up, it's literally abuse. It's torturing me by harming my kidneys biochemically.

Doctors are cops. ACAB.

[lextheraspberry]

I never posted this here but without context it’s really funny

[the-prophecy]

The way I can properly understand body check up reports after this sem is ✨

[lorib643]

Where have I been?

Image: cartoon of several people sitting in chairs. Group therapy. I have several chronic conditions: mental health, type 2 diabetes, sleep apnea, hypothyroidism, hypertension. I am on 9 medications. I was wondering if there is any type of holistic treatment that could help, and searched different terms in my insurance directory. I came upon a mental health facility that is holistic and…

[drrexdexter]

Low Carb Beer Guide UK

Beer lovers who are watching their carbohydrate intake have reason to rejoice! Low carb beer is gaining popularity as a lighter and healthier alternative to traditional beers. In this article, we will explore the world of low carb beer, its benefits, and everything you need to know about making the right choice.

See our full Dr Dexter keto tips site here for a full keto diet guide, tips and recipes.

Introduction to Low Carb Beer

Whether you're on a low-carb diet, managing your blood sugar levels, or simply looking for a lighter beer option, low carb beer can be a great choice. With fewer carbohydrates and calories compared to regular beers, it allows you to enjoy a refreshing drink while being mindful of your health goals.

What is Low Carb Beer?

Low carb beer is a type of beer that is brewed to have a reduced carbohydrate content. Brewers achieve this by using special brewing techniques or substituting traditional grains with low-carb alternatives. The result is a beer that is lower in carbohydrates but still retains its distinct flavour and characteristics.

The Benefits of Low Carb Beer

Low carb beer in the UK offers several benefits that make it an attractive choice for many beer enthusiasts. Firstly, it allows you to indulge in your favourite beverage without worrying about the excess carbs. This can be particularly beneficial for individuals following low-carb or keto diets.

Moreover, low carb beer is often lower in calories compared to regular beer, which can be advantageous for those looking to maintain or lose weight. Additionally, it may have a lower alcohol content, making it a more suitable option for those who prefer a milder buzz.

Understanding Carbohydrates and Beer

To fully appreciate low carb beer, it's essential to understand carbohydrates and their role in beer production. Carbohydrates in beer primarily come from the malted barley used during the brewing process. These carbs are consumed by yeast during fermentation, leading to the formation of alcohol and carbon dioxide.

Popular Brands of Low Carb Beer

In recent years, many breweries have recognized the demand for low carb beer and introduced their own offerings. Some popular brands include Brand A, Brand B, and Brand C. These brands have gained a loyal following due to their commitment to quality, flavour, and low carbohydrate content.

Here are some popular brands of low carb beer in the UK along with a brief description:

BrewDog Punk AF:

 BrewDog is known for its craft beers, and Punk AF is their low carb, alcohol-free option. It offers a bold and hoppy flavour profile, making it a great choice for those seeking a refreshing and full-bodied experience without the carbs.

Adnams Ghost Ship Alcohol-Free:

Adnams Ghost Ship Alcohol-Free is a low carb beer that maintains the distinct flavour of the original Ghost Ship ale. With its citrusy and malty notes, this alcohol-free option provides a satisfying taste without compromising on taste or carb content.

Skinny Brands Lager:

Skinny Brands Lager is a popular choice for those watching their carb intake. It is a crisp and refreshing lager with a lighter body, making it a go-to option for low carb beer enthusiasts.

Thornbridge Big Easy:

 Thornbridge Big Easy is a low carb pale ale that offers a balanced blend of hops and citrus flavours. It provides a smooth and enjoyable drinking experience while keeping the carb content in check.

Guinness Open Gate Pure Brew:

 Guinness Open Gate Pure Brew is a non-alcoholic, low carb version of the iconic Irish stout. It retains the rich and creamy characteristics of Guinness while minimizing the carbohydrate content, making it a great choice for stout lovers.

Pistonhead Flat Tire:

 Pistonhead Flat Tire is a low carb lager with a distinctively smooth taste. It features a crisp and clean flavour profile, making it an excellent option for those looking for a lighter beer without sacrificing flavour.

Peroni Libera 0.0%:

Peroni Libera 0.0% is a non-alcoholic beer that captures the essence of the classic Italian lager. With its delicate balance of bitter and citrus notes, it offers a low carb alternative for beer enthusiasts who enjoy the refreshing taste of Peroni.

Heineken 0.0:

 Heineken 0.0 is a popular choice for those seeking a low carb, non-alcoholic beer. It boasts the same iconic flavour of Heineken but with significantly reduced carbohydrate content, allowing you to enjoy the crisp and refreshing taste without the guilt.

Brooklyn Special Effects:

Brooklyn Special Effects is a flavourful non-alcoholic beer with reduced carbs. It features a blend of hops and malt, creating a complex taste profile that satisfies beer lovers while keeping the carbohydrate count low.

Innis & Gunn Innis & None:

 Innis & Gunn Innis & None is a zero-alcohol, low carb beer that provides a unique and refreshing drinking experience. With its hints of oak and malt, it offers a flavoursome alternative for those looking to reduce their carb intake without compromising on taste.

Becks Blue Alcohol-Free:

 Becks Blue Alcohol-Free is a well-known low carb beer that delivers the familiar crisp and clean taste of Beck's. With minimal carbohydrates, it offers a lighter option for those seeking a refreshing beer without the alcohol content.

Sharp's Doom Bar Zero:

Sharp's Doom Bar Zero is a non-alcoholic, low carb version of the popular Doom Bar amber ale. It provides a malty and slightly sweet flavour profile while being low in carbs, making it an appealing choice for ale enthusiasts.

Estrella Galicia 0.0:

 Estrella Galicia 0.0 is a non-alcoholic beer that captures the essence of the original Estrella Galicia Lager. With its balanced taste and reduced carbohydrate content, it offers a satisfying option for those seeking a low carb beer.

San Miguel 0.0:

San Miguel 0.0 is a non-alcoholic, low carb beer that preserves the distinctive taste of the original San Miguel Lager. It provides a light and refreshing experience with reduced carbohydrates, making it suitable for those watching their carb intake.

St Peter's Without:

St Peter's Without is a low carb, alcohol-free beer that combines traditional brewing methods with modern techniques. It offers a full-bodied flavour profile with hints of malt and hop, ensuring a satisfying drinking experience without the carbs.

Budweiser Zero:

Budweiser Zero is a non-alcoholic beer with reduced carbohydrates that still captures the classic Budweiser taste. It offers a smooth and crisp profile, allowing you to enjoy the flavour of Budweiser while keeping your carb intake in check.

These brands provide a wide range of low carb beer options, each with its own unique flavour profile. Whether you prefer a hoppy ale, a crisp lager, or a rich stout, you can find a delicious low carb option to enjoy while keeping an eye on your carbohydrate intake.

How to Choose the Right Low Carb Beer

When selecting a low carb beer, it's important to consider your personal preferences and health goals. Start by checking the nutritional information provided on the label or brewery's website. Look for beers with lower carbohydrate and calorie counts while still offering the taste and characteristics you enjoy.

Low Carb Beer and Weight Loss

For individuals aiming to shed extra pounds, low carb beer can be a helpful tool. By reducing the carbohydrate and calorie intake from beer, you can create a calorie deficit and potentially support weight loss efforts. However, it's crucial to keep moderation in mind and consider the overall balance of your diet.

Low Carb Beer and Diabetes

People with diabetes often need to monitor their carbohydrate intake to manage their blood sugar levels effectively. Low carb beer can be a suitable choice for individuals with diabetes, as it provides a beer option with fewer carbohydrates that are less likely to cause blood sugar spikes.

Low Carb Beer and Blood Sugar Levels

Even for individuals without diabetes, managing blood sugar levels is essential for overall health. Low carb beer can help maintain stable blood sugar levels since it contains fewer carbohydrates. However, it's still important to consume alcohol in moderation and be aware of any individual reactions.

Low Carb Beer and Taste

One common misconception about low carb beer is that it compromises on taste. However, many breweries have invested in creating flavourful low carb options that can rival traditional beers. With a wide range of styles and flavours available, there's likely a low carb beer that suits your taste preferences.

Low Carb Beer and Hangovers

Excessive alcohol consumption can lead to unpleasant hangovers, regardless of the beer's carbohydrate content. While low carb beer may be gentler on the body due to its lower alcohol content, responsible drinking practices and moderation are still crucial to minimize the risk of hangovers.

Low Carb Beer and Alcohol Content

Low carb beer often has a lower alcohol content compared to regular beer. This can be advantageous for individuals who prefer a milder buzz or those who want to limit their alcohol intake. However, it's important to note that alcohol content can vary among different brands and styles of low carb beer.

Drinking Low Carb Beer Responsibly

When enjoying low carb beer, responsible consumption is key. Set personal limits, be mindful of your alcohol intake, and always prioritize your health and well-being. Additionally, consider alternatives such as non-alcoholic or alcohol-free beer if you prefer to avoid alcohol entirely.

Is Low Carb Beer for Everyone?

While low carb beer can be a great option for many individuals, it may not be suitable for everyone. It's important to consider your specific health needs, dietary restrictions, and personal preferences. If you have any concerns or health conditions, it's best to consult with a healthcare professional before making changes to your beer consumption.

Conclusion On Low Carb Beer

Low carb beer offers a lighter and healthier alternative for beer lovers who want to watch their carbohydrate intake or make mindful choices about their alcohol consumption. With a variety of flavours and brands available, finding a low carb beer that suits your taste preferences is easier than ever. Remember to enjoy low carb beer responsibly and make choices that align with your health goals.

Frequently Asked Questions (FAQs)

Can low carb beer help with weight loss?

 Low carb beer can support weight loss efforts by reducing overall carbohydrate and calorie intake from beer. However, moderation and overall dietary balance are still important for successful weight management.

Is low carb beer suitable for people with diabetes?

Yes, low carb beer can be a suitable choice for individuals with diabetes due to its lower carbohydrate content. However, it's important to monitor blood sugar levels and consume alcohol in moderation.

Does low carb beer compromise on taste?

No, many breweries have focused on creating flavourful low carb beer options that can rival traditional beers. With various styles and flavours available, you can find low carb beer that suits your taste preferences.

Does low carb beer cause fewer hangovers?

While low carb beer may be gentler on the body due to its lower alcohol content, excessive consumption can still lead to hangovers. Responsible drinking practices and moderation are essential to minimize the risk of hangovers.

Can everyone drink low carb beer?

While low carb beer can be enjoyed by many, it's important to consider individual health needs, dietary restrictions, and personal preferences. If you have any concerns or health conditions, consult with a healthcare professional before making changes to your beer consumption.

[lilac-melody]

hm.

[biology-geology-beaches-india]

The Science Research Folios of S. Sunkavally, p 458.

[clatterbane]

One of the things that's actually funny is that I have been eating SO MUCH more sugar (and carbs in general) since I did finally get appropriate treatment, with the supplemental insulin I've needed since at least 2008.

It's extra fun when you already have an ED history, and get plunged into that "you're obviously slowly killing yourself with knife and fork, but what would anyone expect from a lazy fat American?" mentality. Coming not least from the people who are supposed to be helping. The ED brainweasels were certainly having a party for too long, and I probably did my system some extra damage with restriction and overexertion. Whatever I did, it was not going to fix my fucked-up pancreas--and things just kept getting worse as more and more beta cells gradually died off.

I still have to nope right away from too many legit triggering conversations even among people with known autoimmune diabetes. No damned wonder we have like a 30% rate of diagnosable EDs, even on the "I did nothing to cause this, HONEST" autoimmune side of things. (I don't even need to get started on the misplaced Type Wars hierarchical BS again. Pisses me off even worse, as someone who nearly got killed by ending up on the "wrong" side of some terrible assumptions for way too long.)

And that 30% is mostly among people who did not already have disordered eating behavior (or significant scrupulosity problems) going in. It's positively encouraged--again, not least among professionals who are supposed to be helping. While being one of the fastest ways to cause your body serious mischief, especially once you throw supplemental insulin into the mix. If I am never exposed to another word about intermittent fasting or obsessive focus on carb counting with a moralistic tone, it will be way too soon.

Thankfully I have yet to hear one single goddamned word that's not genuinely medically appropriate about my weight or presumed eating habits since I did have that spectacular collapse, and then got to be clinically underweight enough that they have been repeatedly commenting on that--between the mistreated diabetes itself and the resulting GI damage from that final ketoacidosis crash. Regaining some weight and actually feeling hungry again more often, as I keep recovering from that bullshit and am consistently physically able to eat solid food again, has been sort of doing my head in lately. Not least because I do not want to get treated like garbage again, as I do recover and get back to a healthier weight. I have seen how that works, and really do not need a repeat.

There's still too much that's kinda triggering on an ongoing basis, but at least I am quite deliberately telling myself that I can eat whatever the hell I want and mostly actually DOING it. I am now decently equipped with insulin and a CGM to watch my blood sugar levels, and the world is my smörgåsbord at least as much as it is anyone else's.

I may actually go and get some ice cream in a little while. Because I want it, and I do have the technology.

[imheretopostthingsilike]

WHY IS SHE DRKNKING MANISCHEWITZ????

happy valentines day <3

[blueoaknx]

The Impact of High Fructose Corn Syrup on Mitochondrial Function

The Impact of High Fructose Corn Syrup on Mitochondrial Function:

Analysis

High fructose corn syrup (HFCS), a widely used sweetener derived from corn, has become a major component of the modern diet, especially in processed foods and sugary beverages. HFCS is composed of glucose and fructose in varying proportions, with HFCS-55 (55% fructose, 45% glucose) and HFCS-42 (42% fructose, 58% glucose) being the most common formulations. While the impact of HFCS on metabolic health has been widely discussed, recent studies have shown that it can also exert a detrimental effect on mitochondrial function. This technical analysis explores the biochemical mechanisms by which HFCS damages mitochondria, contributing to cellular dysfunction and a range of metabolic diseases.

Mitochondrial Physiology and Biochemical Function

Mitochondria are highly specialized organelles responsible for producing adenosine triphosphate (ATP), the primary energy currency of the cell, through oxidative phosphorylation (OXPHOS). This process occurs in the inner mitochondrial membrane and involves the electron transport chain (ETC) and ATP synthase. The mitochondria are also involved in regulating cellular metabolism, maintaining redox balance, calcium homeostasis, and apoptosis (programmed cell death). Mitochondrial dysfunction, characterized by impaired ATP production, altered mitochondrial dynamics (fusion/fission), and excessive reactive oxygen species (ROS) production, is a key factor in the pathogenesis of many chronic diseases, including obesity, insulin resistance, cardiovascular diseases, and neurodegenerative disorders.

Fructose Metabolism and Its Divergence from Glucose

The metabolism of fructose, particularly in the liver, diverges significantly from that of glucose, and it is this divergence that underpins much of the mitochondrial dysfunction associated with HFCS consumption. Unlike glucose, which is predominantly metabolized via glycolysis and the citric acid cycle (TCA cycle), fructose bypasses the rate-limiting step of glycolysis, catalyzed by phosphofructokinase-1 (PFK-1), and is instead phosphorylated by fructokinase to form fructose-1-phosphate. This rapid metabolism of fructose in the liver can overwhelm metabolic pathways and lead to the accumulation of intermediate metabolites such as dihydroxyacetone phosphate (DHAP) and glyceraldehyde, which can be further converted to fatty acids and triglycerides through de novo lipogenesis (DNL).

Excessive fructose consumption leads to the accumulation of triglycerides, particularly within hepatocytes, which is a hallmark of non-alcoholic fatty liver disease (NAFLD). The lipid accumulation in the liver, in turn, exacerbates mitochondrial dysfunction and oxidative stress, contributing to insulin resistance and a cascade of metabolic disorders.

Mechanisms of Mitochondrial Damage Induced by HFCS

Increased ROS Production

One of the most significant consequences of excess fructose metabolism is the elevated production of reactive oxygen species (ROS). ROS are byproducts of cellular respiration, primarily generated at complexes I and III of the electron transport chain. Under normal conditions, mitochondria have a robust antioxidant defense system, including enzymes like superoxide dismutase (SOD), catalase, and glutathione peroxidase, which help neutralize ROS. However, when cells are exposed to an overload of fructose, the liver mitochondria become overwhelmed, leading to excessive ROS generation.

Fructose metabolism increases the NADPH/NADP+ ratio, enhancing the activity of nicotinamide adenine dinucleotide phosphate (NADPH)-dependent oxidases such as NADPH oxidase (NOX), which further amplifies ROS production. These ROS cause oxidative damage to mitochondrial DNA (mtDNA), lipids in the mitochondrial membranes, and mitochondrial proteins. Such damage impairs mitochondrial function by decreasing mitochondrial membrane potential, disrupting the electron transport chain, and promoting mitochondrial fragmentation. Furthermore, mtDNA is particularly vulnerable to ROS due to its proximity to the electron transport chain and the lack of histone protection, leading to mutations that impair mitochondrial replication and protein synthesis.

Disruption of Mitochondrial Biogenesis

Mitochondrial biogenesis refers to the process by which new mitochondria are synthesized within a cell to meet the energy demands. This process is tightly regulated by several transcription factors, most notably peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-1α). PGC-1α activates the transcription of nuclear and mitochondrial genes involved in energy metabolism, mitochondrial dynamics, and antioxidant defenses.

Fructose consumption has been shown to inhibit PGC-1α expression in both liver and skeletal muscle cells. Reduced PGC-1α levels lead to impaired mitochondrial biogenesis, which limits the ability of cells to adapt to increased energy demands. This is particularly concerning in tissues with high metabolic demands, such as muscle, heart, and liver, where impaired mitochondrial function can exacerbate energy deficits and lead to insulin resistance, fatty liver disease, and other metabolic disorders.

Mitochondrial Permeability Transition and Apoptosis

Chronic exposure to high levels of fructose can lead to mitochondrial permeability transition (MPT), a process in which the mitochondrial inner membrane becomes permeable to ions and small molecules, disrupting mitochondrial function. MPT is typically induced by excessive ROS production, calcium overload, or changes in the mitochondrial membrane potential. The opening of the mitochondrial permeability transition pore (MPTP) leads to the loss of mitochondrial membrane potential, uncoupling of oxidative phosphorylation, and the release of pro-apoptotic factors such as cytochrome c into the cytoplasm. This, in turn, activates the caspase cascade, promoting apoptosis.

In the context of HFCS-induced mitochondrial dysfunction, increased ROS and altered metabolic intermediates, such as ceramides, may trigger MPT and apoptotic pathways, leading to cell death and tissue damage. In tissues such as the liver and pancreas, this can exacerbate the pathological progression of fatty liver disease and insulin resistance.

Fatty Acid Accumulation and Impaired Beta-Oxidation

Excessive fructose consumption induces de novo lipogenesis (DNL) in the liver, leading to an increase in the synthesis of fatty acids, which are esterified into triglycerides and stored within hepatocytes. This accumulation of lipids can overwhelm the capacity of mitochondria to oxidize these fatty acids via beta-oxidation, leading to mitochondrial dysfunction. The accumulation of lipotoxic intermediates such as ceramides and diacylglycerols further impairs mitochondrial function by inhibiting key enzymes involved in mitochondrial energy production.

Moreover, the excess fatty acids can impair mitochondrial membrane fluidity, reducing the efficiency of oxidative phosphorylation. The lipid-induced mitochondrial dysfunction leads to further oxidative stress, creating a feedback loop that exacerbates the metabolic disturbances caused by high fructose intake.

Clinical Implications of HFCS-Induced Mitochondrial Dysfunction

The long-term consumption of HFCS has profound implications for human health, particularly in the context of metabolic diseases:

Insulin Resistance and Type 2 Diabetes: HFCS-induced mitochondrial dysfunction, particularly in liver and muscle cells, contributes to impaired insulin signaling and glucose homeostasis. As mitochondrial function declines, cells become less responsive to insulin, leading to insulin resistance, a precursor to type 2 diabetes.

Non-Alcoholic Fatty Liver Disease (NAFLD): The accumulation of fat in the liver, driven by increased fructose metabolism, leads to mitochondrial damage and dysfunction, which exacerbates the progression of NAFLD to non-alcoholic steatohepatitis (NASH), a more severe form of liver disease.

Cardiovascular Disease: Mitochondrial dysfunction in cardiomyocytes can impair ATP production, leading to reduced contractile function and the progression of cardiovascular disease. The increased oxidative stress and inflammatory mediators associated with mitochondrial damage also contribute to vascular injury and atherosclerosis.

Neurodegenerative Diseases: Impaired mitochondrial function in neurons, driven by high fructose intake, may contribute to neurodegenerative diseases such as Alzheimer's and Parkinson's disease, as mitochondria play a critical role in maintaining neuronal health.

Conclusion

High fructose corn syrup exerts a significant impact on mitochondrial function through several interconnected mechanisms. These include the increased production of reactive oxygen species (ROS), inhibition of mitochondrial biogenesis, induction of mitochondrial permeability transition, and the accumulation of toxic lipid intermediates. These disruptions in mitochondrial homeostasis contribute to the development of insulin resistance, non-alcoholic fatty liver disease, and other chronic metabolic diseases. Addressing the widespread consumption of HFCS and reducing dietary fructose intake could be crucial in mitigating mitochondrial dysfunction and preventing associated metabolic disease

[watercress-words]

Healthy Holiday Eating: Practical Management Tips

Here are some simple effective ways to enjoy holiday foods without sacrificing healthy eating.

What do marshmallows, pumpkins, eggnog, popcorn, and pears have in common? They are foods associated with holiday recipes, and they’re mentioned in songs about Christmas. You’ll also recognize less everyday foods like chestnuts, figgy pudding, collard greens, and wassail. Recipes from Holiday Carols  We enjoy holiday traditions of eating and drinking special foods and beverages; we even sing…