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tinydefector · 10 months ago

Note

Is it too much to ask for a follow-up on the Human' Effects fic?

Masterlist

This is more just some more information of headcanons I have and how I like writing the bots. So I hope you enjoy it. This one's more on the differences and similarities between humans and Cybertronians.

Word count: 2.5k

Warning: mentions of reproduction, and exploration of body's. Valveplug.

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So this is just a continuation for Human effects. This one also delves into some more information on biological, cultural and different frames and how they interact with each other, humans and other organic Creatures.

Biological Humans and Cybertronians are vastly different even with quite a few similarities.

Sparklings and children

There is a very big difference in the body function of Humans and Cybertronians. Size for one but also Organic DNA and CNA. There are many things which can Line up with the other species but also function very differently

Such as.

structure and organ comparison

Plating - skin

Helm - head

Processor, brain module - brain

Faceplate- face

Audio Receptors, Audials, Receptor orifices - ears

Nasal ridge, enstril, olfactory sensors- nose

Optical ridge - eyebrows

Optics, visors - eyes and glasses sometimes visors are used as optics

Intake- mouth, throat or a breath.

Denta, denta plating- teeth

Glossa- tongue

Mandibles (insecticons) - jaw

Vocalizer- voice box

Chin or chin plating are the same

Chestplate, chassis- chest and higher stomach (abs area)

Fuel tanks- stomach.

Backplate, back struts, binary system, bipedalism - back and spine, spinal cord.

Servos and digits - Hands and fingers

Sounder plating - shoulder blades

Pede - feet

pump and Spark - heart and soul

Energon lines - arrays veins.

Vents - lungs, breath.

Pelvic plate - pelvis

Aft, tailpipe, skid plate- butt

Interface panel - covered reproduction organs

Spike - penis

Value - vagina

Carrier chamber, Gestation chamber - womb

Helm and head

With the fact one is filled with circuitry, coding and wires and the other is filled with flesh, fluid and other organic matter. Humans' heads are covered in hair most times. And even those who aren't their head Is still rather soft and smooth. And the bots love playing with human hair and facial hair when they are allowed too.

It also leads to humans giving the bots head scratches, and it's something so man you the bots had never thought of and they love it. They will lay their head in their human lap and just enjoy the gentle touches to their Finial, audials, and helm crest. It becomes. Causal thing of the humans using soft little microfiber cloths to clean out dust and dirt from the small crevices in the bots Plating. Head pats and scratches really becomes something that Cybertronians love alot and it makes a lot of humans consider the bots large cats.

Faceplate and Faces.

One of the things which is very different between humans and Cybertronians is how they show affection to each other. Cybertronians do a thing called a helm hold. Where they each hold their partner's helm in their servos while looking into each other's optics, it's how they show how much they care, because they are focusing only on that one person. And it means alot more after the war, to focus all your attention on just one bots servos shows a lot of trust, affection and love for someone.

While humans have Hugging, kissing. So the bots are rather confused the first time they are hugged, tensing up not wanting to hurt their human. And they nearly short circuit when the human kisses them it's more out of fear.

“Do you know how dangerous that is! What if I crushed you!” The bot hisses in panic while looking at their lover. “not to mention the fact that is my Energon Intake! Do you know what energon can do to Humans!” It nearly sends the bot into meltdowns as they hold their lover's face staring into their eyes trying to show them how much they love and care for them. It would break their spark if they accidentally hurt them.

“it's called a Kiss, I was kissing you” the human tries to explain, their hands cupping around their bots servos.

“a kiss?” the bot inquired. “Yea I'm sorry if you didn't want it, it's just I thought we were in that part of our relationship” the human begins rambling out of anxiety thinking they had messed up. In the end they both settle for a small gesture in-between. Pressing their head and helm, together as they cradle the other.

Eventually they will come around to accepting kisses but it is only for very special occasions. Because the bot will make sure that there isn't a trace of energon in their system for their partner's safety. Over time it becomes them pressing soft kisses to each other's noses.

Skin and Plating

These are all the parts which somewhat are similar to humans, but also work vastly different than the human body does. So with this listed here are many of the things that vary with the similarities.

Plating and skin are vastly different due to one being metal and the other being flesh, it's one of the things a lot of the Cybertronians love is how soft Human skin is. They really enjoy just fondling their human companions, pulling their checks, and enjoying how their skin moves. How pliable, warm and squishy they are. Cybertronians finding out about human breasts really takes them by storm.

“What are those?” the bot asks while pressing a finger to their breast feeling how soft and squishy they are.

“breast, boobs, tits they have a lot of names”

“What are they for?” The bot continues to just slowly play with them out of curiosity, not knowing what the human would need them for.

“they are used for feeding babies, they fill with milk, it's not a constant thing and not everyone's do but they are for feeding babies.” the human tries to explain and it just leaves the bot shocked.

“You're with Sparkling?” The bot asked as they began fussing over the human more, gently pressing their digits to the human's body more.

“no, no I'm not pregnant!” They laugh out loud while rather embarrassed. “‘but wouldn't they deflate?” The bot shoots back as their digits begin needing the flesh which makes the humans sigh and lean into the touch. “human babe, don't have the same functions as you.” They tease softly.

It ends up with one bot having their human lover back pressed to their Chassis. The bot's servos just cupped around their partners breast slowly massaging them as the human leans back just enjoying the feeling because it takes the weight off their back and the cool touch of the metal feels delightful against their skin.

Heart and spark

The difference between a human heart and spark aren't that different at all. They both pump blood/energon to where it's needed, it's the life provider of the body. Each has a beat or pulse. And the said beat and pulse sounds different. A human's heart beat feels like a thump but to Cybertronians it's an echo. Each beat they can feel and see like A beating light. And they love how it feels laying against them, their spark will actually fall in tune With their heart beat as a way to calm the human. While for humans a Cybertronians spark pulse feels like electricity dancing across their skin it's like the build up of static but it doesn't zap. The vibration of a spark is like energy building and releasing, the buzzing sound that just resonates through their body as they lay against their bot.

olfactory sensors and nose

Unfortunately humans don't have the enhanced scent sensors that a lot of other species do, and Cybertronians have one for the most advanced ones, they don't just smell it but they can break down the chemical compound to its base and are able to tell humans emotions based on how they smell. It also leads to bots becoming rather touching with their lovers when they can smell their cycle. It also leads a lot of bots realising they have a breeding kink after being with a human, because the moment they can feel their partners change in hormones they are hovering. It becomes an even bigger thing when they smell the scent of a young spark, they feel the EM Field.

carriers and pregnancy

There is a major difference between human pregnancy and cybertronian pregnancy. Humans can only be born from reproduction. a new spark can be formed in multiple ways.

-Forged.

-Cold construct.

-split spark

- Sparked

Forged new sparks are bots that are formed in hotspots across cybertron and on occasions sparklings can also be formed from these hot spots.

Cold constructs are bots that have been made by others for a purpose and were originally classed as 2nd class citizens, miners or lower than other bots,

Split Sparks made from splitting your spark into another form. It was very rare due to multiple laws being inplace against it.

Sparklings were formed through spark merging with another and creating enough energy to form new lifeforms. A carrier would then have to host said spark in their Gestation chamber until the spark could grow its own protoform. Then from there they are moved into the carrier chamber where they learn off their carrier's coding, and also receive food, coding and personal information from their Sire via Transfluid. As sparklings are still not able to consume normal energon and it has to be processed down enough for the sparkling. (Similar to how humans breastfeed) from there once they are ready the sparkling will be ‘birthed’ and from their they will need to be carried in a spark chamber until they have fully developed but gives them time to learn the world around them but still have the safety of a parent to protect them.

This leads the bots and humans to both be horrified at the differences of the others' reproduction. The bots are horrified over the fact a human's pelvis bone breaks just to birth a baby. But also the fact that humans can carry more than one child. They eventually watch a documentary over human birth; it makes a lot of bots short out and crash.

Humans on the other hand are shocked over the time it takes for a bot to have a sparkling. 100 years is longer than a lot of humans ever live but it's how long it takes for the full process of a sparkling to be formed and born. That's without all the issues with CNA, temperature, spark energy, energon. A Lot of Cybertronian pregnancies don't make it to term due to these factors.

So when by some chance a human gets pregnant by a Cybertronian it has the whole planet up in a tissy. Not just the fact of how genetically different they are but how it happened. The first human Cybertronian sparkling is a miracle watched by man and documented. And it turns out the human womb is actually the best possible hosting spot for the start of a sparkling, it's the perfect temperature, and it's not a temperature a lot of bots can keep their own frames. The human womb actually short cuts a lot of time over the birth Due to the sparkling Not needing to be shifted from one chamber to another. It comes down to being pregnant for 3 years. It's a long time for a human but it's decades Less than what it normally takes for a Cybertronian if they made it through the full progress.

And when the sparkling is born it's discovered that the sparkling doesn't have any human traits, defects or appearance. Due to the human body mainly working as a host, the CNA and DNA don't mix when it comes to creating a sparkling but they work perfectly in sync When it comes to helping the sparkling grow. And it also turns out humans are able to sustain more than One sparkling.

That also brings me to the function of spike and Valves. For Cybertronians spikes and Valves aren't how Sparklings are created, sparklings are created from two sparks merging together and creating enough energy for a sparkling but interface is needed to start the process of how they form. Sparkling needs Transfluid to begin and that is what Cybertronians use interfacing for outside of sharing memories, information and emotions. Most times Cybertronians interface for fun, feeling close, sharing information with a loved one, or to help feed a sparkling the necessary data, fluids and programming.

so When a Cybertronian and human interface it has a lovely mix of a 50/ 50 chance of getting pregnant due to how the human and cybertronian heart and spark link in a frequency that is almost essential Spark merging. And a human doesn't even need to interface with a Cybertronian to get pregnant.

Here is a list of ways humans have gotten pregnant/ a bot has gotten pregnant.

-interfacing

-spark bonding

-a human touching a bots spark.

-having enough hated for another you get them pregnant by sheer Anger

- spark And heart syncing

-A human being on their cycle will make a bot pregnant.

______________

Megatron entered the medbay of the Lost Light, feeling unusual warmth and pressure in his chest. "Ratchet," he said gruffly to get the medic's attention. "Something is...off. I feel as if I have consumed fool's energon again, but I know that is not the case."

He looked down at the medic, his optics betraying slight concern beneath his usual stern demeanour. "Examine me and determine what ails me. I need to be at full function." His pride did not allow him to admit weakness easily, but he trusted Ratchet's skills.

Ratchet nodded to First Aid and They as they stood ready to assist. He turned back to Megatron with a scrutinising gaze.

"When did you first notice the symptoms? Any other anomalies in your systems?" he asked gruffly, scanning the Decepticon warlord from head to foot with a diagnostic tool. The scans showed unusual activity in Megatron's Gestation chamber.

"Hmm...it appears your spark is pulsing more rapidly than normal. And the pressure you described suggests a buildup of energon flow." Ratchet paused, analysing the data. "This could indicate...no, it's not possible. Or is it...?" He leaned in closer, inspecting Megatron with keen optics.

"We'll need a more detailed scan. Over here, lay back - this won't hurt but may feel peculiar. First Aid, fire up the resonator. Ambulon you're in charge of monitoring vitals."

"What's wrong, ratchet he was fine this morning?" The human asked in concern.

Megatron lay back on the medical berth as directed, his massive frame dwarfing its size. his expression softened ever so slightly. As the detailed spark scan began, Ratchet's optics widened in surprise. "By the Allspark...it can't be..." He motioned First Aid "Look here. What do you see?"

First Aid peered at the monitor in amazement. "Two distinct spark pulses...but how is that possible?" Ratchet glanced over at Megatron, then back at the others. "It would seem Megatron himself is carrying sparkling. The increased energon flow and pressure were signs of protoform development beginning."

He chuckled wryly. "Well Megatron, it seems that fool's energon was not to blame after all. Congratulations...you're going to be a creator." Megatron's optics widened in disbelief at Ratchet's announcement. Carrying sparkling? It made no sense as far as he knew, spark merging could only occur between cybertronians and he had only been intimate with a human.

He sat up abruptly, almost knocking First Aid over, and glared down at Ratchet. "Explain yourself, medic! How is this possible? The human and I have been intimate but they clearly lack our means of conception." Ratchet held up a calming hand. "Peace, Megatron. I have a theory,"

Taglist: @angelxcvxc

@ladyofnegativity

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thoughtportal · 2 months ago

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In eastern Mexico’s underground caverns and streams, a blind fish undergoes a peculiar adolescence: as it approaches maturity, taste buds begin to sprout under its chin and on top of its head, creeping toward its back.

“It’s a pretty wild amplification of the sensory system of taste,” says Josh Gross, an evolutionary geneticist at the University of Cincinnati and a co-author of a recent study on the cave fish in Nature Communications Biology. Gross and his team discovered that the new buds blossom around the time when the fish transition from eating larval crustaceans to gobbling up their adulthood staple: bat guano. Taste buds outside their mouths might be helping the fish detect bat droppings in the utterly dark, “food-starved” caves, Gross says.

Wandering taste buds aren’t unheard of elsewhere, especially in other fish. Some damselfish cultivate taste buds on their fins, and channel catfish have them across their midsections. And as alien as it may seem, many cells throughout the human body can taste, too. They’re just not sharing the flavors with your brain like taste buds do.

Lora Bankova is a Harvard Medical School respiratory biologist who studies tuft cells, a cell type sprinkled within human mucous tissues like those lining your nostrils, throat and gut. These “rapid responder” cells trigger the immune system if they detect an outside threat, and many of them rely on built-in taste receptors (the same kinds found on taste-bud cells) to do so. Bankova notes that many potentially harmful bacteria communicate via signaling chemicals called lactones—which also happen to activate taste receptors attuned to bitter flavors, prompting tuft cells’ immune response. And it turns out that even environmental allergies may be a matter of taste: dust mites and several mold species can also set off a tuft cell’s taste receptors, Bankova says.

“Evolutionarily, taste receptors [have moved around] the body to protect us from the air we inhale and all the attacks we’re getting through the orifices,” Bankova says. “They’re in the inner ear, the urethra, everywhere something can get into your body.”

Such “extra” taste receptors aren’t just bouncers at the door—they taste test for our internal systems, too. Receptors for sweet tastes help to tune insulin production in the pancreas and make sure neurons in the brain have access to enough glucose. Sweet, bitter and umami receptors in the gut modulate digestion.

Gross says it’s still a mystery what taste receptors the bat guano activates in the blind cave fish. “There may be some sugar content if it’s a fruit bat, maybe some protein content if it’s a carnivorous bat,” he says. So far only the cave fish has signed up to sample it.

#article #scientific american #fish #science #biol #evolution #genetics

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covid-safer-hotties · 3 months ago

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Also preserved in our archive

Hey! Look! A great breakdown of that thing I'm always talking about being a big yet entirely-overlooked deal by 90% of medical professionals in regards to this particular virus!

SARS-CoV-2, the virus behind COVID-19, is not done with us. Over the past four years, it has shown a remarkable ability to adapt, with each new variant outmaneuvering our immune systems in unique ways. The recently published study on the XEC variant (November 22, 2024) provides fresh insights into how this virus is evolving. (1) Combining this with the broader history of immune evasion, we see a troubling pattern: the virus continues to find ways to evade the immune system and in many cases, persist, potentially leaving lasting impacts on our health even for those who experience only mild or asymptomatic infections.

What the Study Found: XEC’s Immune Escape Arsenal The latest study revealed that the XEC variant—an offspring of two previous variants, KS.1.1 and KP.3.3—has developed mechanisms that make it harder for our immune systems to neutralize it. Here’s how it works:

1. Glycosylation Mutations in the N-terminal Domain (NTD):

The XEC variant introduces new glycosylation sites, such as the T22N mutation, which act like a cloak, hiding key parts of the virus from antibodies.

These sugar molecules shield the receptor-binding domain (RBD), a crucial target for vaccines and natural immunity, making it harder for antibodies to bind and neutralize the virus.

2. Allosteric Effects:

Mutations in the NTD don’t just shield the virus—they also alter the behavior of the RBD through a process called allostery. These changes can make the RBD less accessible or alter how it interacts with human cells, further reducing the effectiveness of antibodies.

3. Potential Impact on Membrane Fusion:

The study hints that these mutations may also enhance how efficiently the virus fuses with human cells, potentially increasing its infectivity.

Immune Evasion: A Constant Tug-of-War The ability of SARS-CoV-2 to adapt is not new. Looking back at the history of immune evasion, we see a pattern:

The Early Days: Mutations like D614G made the virus more infectious.

Alpha and Beta Variants: N501Y and E484K mutations increased binding to human cells and evasion of neutralizing antibodies.

Omicron Era: A flurry of spike protein mutations allowed the virus to reinfect people with previous immunity and bypass vaccine-induced protection.

XEC is the next chapter in this story, combining these strategies with new tricks like glycosylation and allosteric modulation to stay ahead of human defenses.

Why This Matters: Beyond Infections Understanding immune evasion isn’t just about tracking infections—it’s about long-term health impacts. Here’s why this evolution is particularly concerning:

1. The Shadow of Long COVID:

Millions of people suffer from Long COVID, characterized by fatigue, brain fog, heart palpitations, and muscle pain. The virus’s ability to persist and evade the immune system might explain why symptoms linger for months or years in some individuals.

Chronic immune activation or hidden reservoirs of the virus could drive these long-term effects.

2. Asymptomatic but Chronic Damage:

Even in people without noticeable symptoms, SARS-CoV-2 has been shown to cause subtle, potentially long-term damage to:

Vascular systems: Leading to inflammation and microclot formation.

Neurological function: Disrupting brain activity and potentially accelerating neurodegenerative conditions. Early onset dementia

Musculoskeletal health: Causing unexplained weakness or pain.

Cognitive performance: Contributing to memory issues and reduced mental clarity. Are you or someone you know having more trouble finding words to use or losing things more often?

3. Vaccines Alone Aren’t Enough:

While vaccines remain essential, their effectiveness is limited by the virus’s rapid evolution. Variants like XEC show how SARS-CoV-2 can sidestep even the most advanced immune defenses, highlighting the need for next-generation vaccines targeting broader parts of the virus. We have know this for a long time now so where are the broader targeting vaccines?

The Future of SARS-CoV-2 Evolution The virus has already demonstrated its ability to adapt to our immune responses in multiple ways, and there’s no reason to believe it will stop. Here are some possibilities for future adaptation:

Further Refinement of Glycosylation: Adding or modifying sugar molecules could make the virus even more difficult to detect.

Enhanced Membrane Fusion: Mutations that improve how the virus merges with human cells could increase its infectivity.

Host Adaptation: Over time, the virus could become better at hiding within human cells, evading both natural immunity and therapeutic interventions.

Increased Chronicity: The virus might evolve to persist at low levels in the body, leading to ongoing inflammation and long-term health consequences.

What We Can Do: Adapting to the Virus’s Adaptations The XEC variant and others like it remind us that SARS-CoV-2 is still a formidable opponent. Here’s what we can do:

1. Invest in Better Vaccines:

Universal or pan-coronavirus vaccines that target conserved regions of the virus are critical.

2. Improve Diagnostics:

Detecting chronic or asymptomatic infections early could help mitigate long-term health effects.

3. Focus on Treatment:

Antiviral drugs that target different parts of the virus, combined with treatments for inflammation and immune dysregulation, could help reduce the impact of Long COVID.

4. Stay Vigilant:

For individuals, maintaining basic preventive measures during high transmission periods can significantly reduce risks.

Conclusion: Learning from the Virus SARS-CoV-2 is teaching us a harsh lesson about evolution. Its ability to adapt and evade our defenses, from antibodies to T-cells, shows no sign of slowing down. Variants like XEC underscore the importance of continued research, innovation, and public health vigilance. By understanding the virus’s strategies and preparing for its next moves, we can better protect ourselves—not just from acute infections but from the long-term consequences.

Reference:

Enhanced immune evasion of SARS-CoV-2 variants KP.3.1.1 and XEC through N-terminal domain mutations (November 22, 2024)

www.thelancet.com/journals/laninf/article/PIIS1473-3099%2824%2900738-2/fulltext

#mask up #public health #wear a mask #pandemic #covid #covid 19 #wear a respirator #still coviding #coronavirus #sars cov 2

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trevlad-sounds · 4 months ago

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Invisible Club 036

23.10.2024

Intro 00:00 Oceanographer–Moon Flower 01:24 Parallel Worlds–Just Strange 06:40 Nacht Plank & Futuregrapher–Sky High 9.06 10:10 The Home Current–Mini Drifter 16:03 Receptor Modulator–Invade 19:35 Battaglia–Fight 26:23 Psycho Kick–Black sky 27:19 Bernard Grancher–Courir pour rire 30:46 Gaudi Kosmisches Trio–Luxury Squat 36:04 gribbles–Childer 43:07 Aerophobia–RT. Corps 46:13 Town and County–Salcombe Surge 50:13 Peltiform–Jitr ft. Room of Wires 54:24 Garber–First Contact 58:35 Tadhe–Unwanted Evil 1:06:15 Kayla Painter–Ice Shells 1:11:06 Outro 1:15:22

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healthlineonline · 4 months ago

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Buy Tamodex to Regulate Estrogenic Impacts in Steroid Cycles

Tamoxifen is a selective estrogen receptor modulator marketed under the brand name Nolvadex. This is one popularly used anti-estrogen endocrine therapy to cure breast cancer. Tamoxifen citrate is produced with a mixture of pure tamoxifen and citrate acid. Apart from its medical uses, tamoxifen citrate is also used in the bodybuilding grounds for its ability to prevent estrogenic side effects such as water retention, and gynecomastia.

#Tamodex #Tamoxifen Citrate for Sale #Estrogen Receptor Modulator

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brightlotusmoon · 3 months ago

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The endocannabinoid system (ECS) is a biological system first discovered in the late 1980s and early ’90s. It is largely composed of endogenous cannabinoid molecules (endocannabinoids) together with the receptors they interact with and enzymes that regulate their levels in the body. This simply means that the body produces native molecules which are similar in certain ways to plant cannabinoids like THC and play an important role in our normal biology.

The different pieces of the ECS “work together” to modulate everything from sleep to mood, memory, appetite, reproduction, and pain sensation. Scientists still have plenty of questions about the human endocannabinoid system and how it functions, but there is an overarching principle that the ECS seems to embody within the bodily tissues it helps regulate.

Homeostasis: Staying in the Goldilocks zone

#this explains why the fibromyalgia symptoms have lessened #yay weed #cannabis and chronic pain

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justkidneying · 1 month ago

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What kind of critical care medications are available to use on a patient? What makes them work?

Thanks for the ask! There's dozens of meds I've seen used in critical care situations, so I will just go through a few of them that I think are most helpful.

Nitroglycerin is used when patients are having a hypertensive crisis. It comes in little pills that they put under their tongue (sublingual administration). The body breaks this down to make nitric oxide. This is the same thing that your body makes when you need to lower your blood pressure. The endothelium of your vessels makes this, and can be signaled to do so by several molecules and transmitters. This vasodilates, lowering blood pressure and allowing tissue to be perfused better.

Albuterol is a bronchodilator that is used to treat asthma and COPD. It is typically inhaled. This is a ß2 agonist that binds to the receptors on the smooth muscle of airways. When it does this, it causes adenyl cyclase to make ATP in cAMP. This does three things. First, it inhibits inflammatory cells. It also causes hyperpolarization of the muscle cells, preventing contraction. Finally, it decreases calcium in the muscle cells and prevents the phosphorylation of myosin (a muscle fiber), both of which inhibit muscle contraction.

Epinephrine is most commonly used to treat anaphylaxis and asthma. It can be injected or inhaled. It acts on adrenergic receptors, and is also a hormone and neurotransmitter made by your body. The effects of it are the same as the effects of the sympathetic nervous system. So it will increase heart rate and contractility, increase respiratory rate, bronchodilate, inhibit insulin, and increase the breakdown of glycogen. On lists of its effects, you'll see that it vasodilates and vasoconstricts, but what it really does is decrease peripheral blood flow by constricting those vessels, and increase the diameter of coronary vessels.

Atropine is an antimuscarinic that is used to treat bradycardia (slow heart rate) and several types of poisoning. It does this by blocking muscarinic receptors, which can be activated by acetylcholine. This will decrease the slowing effect of the parasympathetic nervous system (inhibiting the inhibition and causing sympathetic effects), thereby increasing heart rate. In organophosphate poisonings (pesticide) and soman/sarin gas attacks, it acts the same way. In these poisonings, the enzyme that breaks down ACh (a neurotransmitter) is inhibited, and an accumulation of ACh occurs. Atropine is a competitive antagonist of ACh, meaning it locks into the same receptors but does nothing. It is usually used with another drug (pralidoxime), which can regenerate the enzyme that breaks down ACh. A fun fact about atropine is that it is found in the deadly nightshade (belladonna) plant, and is a poison itself (I mean everything can be a poison in the right amount but this is like a famous one).

Narcan is an opioid receptor antagonist, used for opioid overdoses. It comes as a nasal spray, as this allows it to bypass the blood-brain barrier and be absorbed really quickly. Its mechanism of action is that it blocks opioid receptors but doesn't do anything (conversely, opioids activate those receptors and modulate pain). One fun fact about this one is that someone should not need more than two doses of it. I've seen firefighters give someone three or four doses of Narcan and the person is not waking up. Don't do that. Something else is wrong and you should probably deal with it instead of wasting more Narcan.

If you need anything explained better, just send another ask, DM me, or comment on this post.

I hope I answered your ask well enough, and thanks again :)

#medicine #med studyblr #questions #medical writing #med student #medications #critical care

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humancelltournament · 5 months ago

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Propaganda!

A megakaryocyte is a large bone marrow cell with a lobated nucleus that produces blood platelets (thrombocytes), which are necessary for normal clotting. Once the cell has completed differentiation and become a mature megakaryocyte, it begins the process of producing platelets. The maturation process occurs via endomitotic synchronous replication whereby the cytoplasmic volume enlarges as the number of chromosomes multiplies without cellular division. The cell ceases its growth at 4N, 8N or 16N, becomes granular, and begins to produce platelets.

Cytokines are a broad and loose category of small proteins (~5–25 kDa) important in cell signaling. Due to their size, cytokines cannot cross the lipid bilayer of cells to enter the cytoplasm and therefore typically exert their functions by interacting with specific cytokine receptors on the target cell surface. Cytokines have been shown to be involved in autocrine, paracrine and endocrine signaling as immunomodulating agents. They act through cell surface receptors and are especially important in the immune system; cytokines modulate the balance between humoral and cell-based immune responses, and they regulate the maturation, growth, and responsiveness of particular cell populations. Cytokines are important in health and disease, specifically in host immune responses to infection, inflammation, trauma, sepsis, cancer, and reproduction.

#Megakaryocytes #Cytokines #poll #polls #tumblr poll #tumblr polls #tournament poll #wikipedia #cells of the human body #science tournament #biochemistry

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psi-hate · 6 months ago

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forcefem this forcefem that. Must we use such blunt force measures? Can't a girl have an 80%+ success rate at convincing "cis" dudes to go on e through persuasion and encyclopedic knowledge of selective estrogen receptor modulators they'll stop taking within the month alone?

^ you rn

don't make me shove u into a locker that turns you into a fox

#pk.text

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fangdokja · 9 days ago

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Hello hello!

I just finished paternal privilege (I love it very much) and dunno if this has been asked before but I am very curious if the drug you mentioned in the last chapter is real or if it's not, what is it inspired by?

Is it like a real life animal-grade drug that you ✨enhanced for the story✨ or is it just entirely made up? Either way, it sounds very interesting with how you wrote it (but i find it terrifying irl lmao)

Thank you, and I hope you have a wonderful day!

Consent is a game he lets you think you’re winning.

❤︎ Synopsis. Love isn’t a choice when it’s rewritten into your very brain—when fear, devotion, and desire are nothing more than chemical commands. You don’t know who you were before him, only that now, you could never leave.

♡ Book. Forbidden Fruits: Intimate Obsessions, Unhinged Desires.

♡ Pairing. Yandere! Stepfather x Fem. Reader

♡ Novella. Paternal Privilege - Part 7

♡ Word Count. 1,350

❤︎ Abstract.

The neuropsychopharmacological agent described in Paternal Privilege is a fictional compound engineered to manipulate emotional and cognitive processes through targeted biochemical interventions. While no exact counterpart exists in contemporary medical or veterinary pharmacology, the drug’s theoretical underpinnings are extrapolated from real-world substances known to modulate neurological, hormonal, and behavioral states. This research explores the scientific plausibility of such a compound, its mechanisms of action, and its inspirations from existing psychotropic and neuroactive substances.

❤︎ Introduction.

Psychopharmacology has long sought to manipulate human cognition and behavior through chemical intervention. Existing compounds, such as benzodiazepines, selective serotonin reuptake inhibitors (SSRIs), oxytocin analogs, and certain dissociative anesthetics, demonstrate the feasibility of targeted neurochemical modulation. The drug described in Paternal Privilege functions as a multi-phase neuromodulator, selectively impairing resistance mechanisms while reinforcing attachment, dependency, and learned helplessness. This analysis explores its theoretical design by synthesizing knowledge from neurobiology, psychopharmacology, and behavioral conditioning.

❤︎ Phase One: Neurological Recalibration.

The first phase of the drug targets specific neural structures, particularly the amygdala, prefrontal cortex (PFC), and ventral tegmental area (VTA), to create a paradoxical state of heightened fear and attachment.

♡ Amygdala Modulation.

The amygdala, central to processing fear and emotional memory, is influenced by compounds such as β-carbolines, which act as inverse agonists at the benzodiazepine receptor sites of GABA-A receptors.

Unlike traditional anxiolytics, which enhance GABAergic inhibition, an inverse agonist induces hyperactivity, leading to increased fear sensitivity and anxiety. Comparable effects are seen in substances like FG-7142, a β-carboline derivative known to induce heightened stress responses.

By simultaneously inducing a controlled fear response while reinforcing attachment mechanisms, the drug could create dependency similar to trauma bonding seen in abusive relationships.

Real-World Use: β-carbolines are found in some plant-based hallucinogens and have been tested for experimental anxiety treatments. Substances that increase amygdala activity are used to study fear responses, PTSD, and phobia treatments. Certain interrogation drugs work by heightening fear and lowering defenses, making subjects more compliant.

♡ Prefrontal Cortex Suppression.

To undermine rational resistance, the compound must reduce prefrontal cortical activity. The PFC regulates impulse control, logical reasoning, and executive function.

Ketamine and phencyclidine (PCP), NMDA receptor antagonists, achieve this by disrupting glutamatergic signaling, impairing cognitive processing and executive function. This effect would be fine-tuned in the fictional drug to create cognitive fog rather than full dissociation.

A controlled dampening of PFC activity could subtly reduce resistance without causing overt sedation, ensuring that the subject remains functional while experiencing increased suggestibility.

Real-World Use: Low-dose ketamine is used for depression treatment, but high doses can cause cognitive fog and detachment from reality. In psychiatric treatments, ketamine is used to "reset" certain cognitive processes in depression patients. In interrogation and manipulation, similar cognitive impairment techniques have been theorized for inducing compliance.

♡ Ventral Tegmental Area.

The VTA, part of the mesolimbic dopamine system, is involved in reward processing and reinforcement learning. Psychostimulants (e.g., amphetamines, cocaine) artificially increase dopamine levels, creating reward-seeking behavior.

Elevating dopamine in response to the captor’s presence could create a conditioned association between compliance and neurochemical reward, reinforcing attachment.

Real-World Use: Dopaminergic drugs treat ADHD but can also cause compulsive behaviors (e.g., gambling addiction). Dopaminergic manipulation is also used in addiction treatment and behavioral therapy. Chronic exposure to dopamine-triggering situations (such as trauma bonding) reinforces learned attachment.

♡ Learned Helplessness Induction.

Chronic stress exposure and intermittent reinforcement have been shown to condition subjects into passivity. Rodent studies demonstrate that unpredictable stressors combined with benzodiazepine withdrawal enhance learned helplessness, a phenomenon mirrored in individuals suffering from long-term trauma.

❤︎ Phase Two: Hormonal Manipulation.

The second phase of the compound operates via controlled fluctuations in key neurotransmitters and hormones, primarily oxytocin, serotonin, and cortisol.

♡ Oxytocin Modulation.

Oxytocin, colloquially known as the ‘bonding hormone,’ plays a crucial role in attachment formation. Synthetic oxytocin analogs have been explored for therapeutic use, particularly in conditions like autism spectrum disorder and social anxiety.

However, elevated oxytocin can paradoxically reinforce emotional dependence, particularly when paired with a stressor. Studies on prairie voles (Microtus ochrogaster) indicate that oxytocin release during stress enhances monogamous pair bonding.

Generally, Intranasal oxytocin administration increases trust even in situations where deception is likely. The drug induces artificially elevated oxytocin levels to create an illusory sense of trust and emotional connection with the captor.

Real-World Use: Used experimentally to help autism patients with social processing. Certain abusive relationships exhibit oxytocin-mediated attachment despite mistreatment.

♡ Serotonin Instability.

Serotonin regulates mood and emotional stability. SSRIs (e.g., fluoxetine, sertraline) can artificially stabilize mood, whereas serotonergic psychedelics (e.g., LSD, psilocybin) can induce suggestibility.

Mild serotonin depletion has been linked to increased emotional reactivity and depressive states. SSRI withdrawal effects mimic the instability described in the novel, wherein fluctuating serotonin levels lead to heightened sensitivity to both comfort and distress, reinforcing the abuser’s dual role as tormentor and savior.

By dysregulating serotonin homeostasis, the subject experiences emotional instability, leading to reliance on an external stabilizing presence—the captor.

Real-World Use: Antidepressants regulate serotonin, but sudden discontinuation causes instability. Controlled serotonin instability can make individuals more susceptible to external emotional influence.

♡ Cortisol Elevation and CRH Stimulation.

Cortisol is the body’s primary stress hormone. Cushing’s syndrome and PTSD studies demonstrate that chronic stress alters brain function, impairing memory and increasing submissiveness.

Chronic stress exposure increases corticotropin-releasing hormone (CRH) activity, priming the brain for hypervigilance and emotional instability. This is evident in victims of prolonged abuse, where heightened CRH correlates with difficulty in emotional regulation and attachment disorders.

Fluctuating cortisol levels induce a persistent state of mild stress, reinforcing helplessness and dependency.

Real-World Use: Chronic stress increases CRH (corticotropin-releasing hormone), which heightens fear responses. Stress conditioning is observed in long-term abuse victims, where cortisol elevation reinforces dependency on an abuser.

❤︎ Phase Three: Cognitive Conditioning.

The final phase involves targeted memory distortion and neural pathway reinforcement.

♡ Hippocampal Interference.

The hippocampus is responsible for consolidating explicit memories.

Midazolam and scopolamine disrupt short-term memory encoding, leading to confusion and suggestibility. Also, Propranolol, a beta-blocker, has been studied for its effects on memory reconsolidation.

By disrupting noradrenergic activity during emotionally significant events, it impairs the retrieval of trauma-related memories. The fictional drug could employ a similar mechanism, selectively altering how past experiences are encoded.

The drug weakens episodic memory consolidation, causing retroactive distortion—the subject rationalizes their compliance as self-driven rather than externally imposed.

Real-World Use: Midazolam is used in surgeries to prevent distressing memories; scopolamine has been (controversially) linked to criminal use in causing compliance. Controlled memory distortion is used in therapeutic interventions for trauma patients.

♡ Dopaminergic Reinforcement Pathways.

Neural plasticity allows experiences to shape long-term behavior.

Dopaminergic reward circuitry underlies behavioral conditioning. Drugs such as amphetamines artificially enhance dopamine release, increasing motivation and reinforcement of learned behaviors. By subtly modulating dopaminergic transmission, the drug could strengthen neural pathways associated with submission and attachment.

Through long-term potentiation (LTP), submissive behaviors become habitual and instinctive, making reversal exceedingly difficult.

Real-World Use: Used in habit-forming therapies for Parkinson’s and addiction treatment. Habit formation through dopaminergic reinforcement is key in addiction therapy and behavioral conditioning.

❤︎ Delivery Mechanisms.

The fictional compound’s administration method ensures gradual and undetectable accumulation.

♡ Olfactory Absorption.

Volatile psychoactive agents have been explored in real-world applications, notably in military-grade incapacitating agents. Aerosolized scopolamine, for example, can be absorbed via mucous membranes, inducing suggestibility.

Real-World Use: Used in some criminal cases to induce compliance.

♡ Dermal Penetration.

Lipophilic compounds such as fentanyl analogs are transdermally active, allowing sustained release through skin contact.

Real-World Use: Transdermal patches (e.g., nicotine, painkillers) deliver drugs gradually.

♡ Ingestion.

Slow-release formulations akin to microdosed psychoactives ensure cumulative systemic integration without immediate sedation.

Real-World Use: Used experimentally for productivity enhancement.

❤︎ Conclusion.

While no single drug matches the complex profile of the compound described in Paternal Privilege, its theoretical construction draws upon established pharmacological principles. By integrating elements from neuroenhancers, anxiogenics, hormonal regulators, and cognitive modifiers, such a substance could feasibly exist under controlled experimental conditions.

However, ethical considerations and existing medical regulations render its real-world application implausible outside of speculative fiction. The described mechanisms highlight both the possibilities and dangers inherent in biochemical manipulation of cognition and behavior.

❤︎ Resources.

1. Neurological Recalibration

• Amygdala Modulation & β-Carbolines – Janak, P. H., & Tye, K. M. (2015). “From circuits to behaviour in the amygdala.” Nature, 517(7534), 284–292.

This review covers amygdala circuitry in fear and emotional memory. It helps explain how inverse agonists at benzodiazepine sites (as with β-carboline derivatives) could heighten fear responses.

• Inverse Agonism and FG-7142 – Millan, M. J. (2003). “The neurobiology and control of anxious states.” Progress in Neurobiology, 70(2), 83–244.

This work discusses the role of β-carbolines like FG-7142 as inverse agonists, detailing how they alter GABAergic tone to enhance stress responses.

• Prefrontal Cortex Suppression (Ketamine/PCP Effects) – Krystal, J. H., et al. (1994). “Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses.” Archives of General Psychiatry, 51(3), 199–214.

This study reviews how NMDA receptor antagonism impairs PFC function, supporting the concept of controlled cognitive “fog.”

• Ventral Tegmental Area and Dopaminergic Reinforcement – Wise, R. A. (2004). “Dopamine, learning and motivation.” Nature Reviews Neuroscience, 5(6), 483–494.

This paper explains how dopaminergic circuits (originating in the VTA) drive reward and reinforcement processes, key to understanding conditioned attachment.

• Learned Helplessness – Maier, S. F., & Seligman, M. E. P. (1976). “Learned helplessness: Theory and evidence.” Journal of Experimental Psychology: General, 105(1), 3–46.

This classic paper lays the groundwork for how chronic stress and unpredictable adverse events induce a state resembling learned helplessness.

2. Hormonal Manipulation

• Oxytocin Modulation and Social Bonding – Young, L. J., & Wang, Z. (2004). “The neurobiology of pair bonding.” Nature Neuroscience, 7(10), 1048–1054.

This review details oxytocin’s role in bonding and attachment and provides insight into how elevated levels could reinforce emotional dependency.

• Serotonin Instability – Harmer, C. J., et al. (2003). “Antidepressant drug treatment modifies the cognitive processing of threat in anxious patients.” American Journal of Psychiatry, 160(2), 370–373.

This study describes how alterations in serotonin can lead to mood instability, a mechanism relevant to the drug’s proposed effect on emotional reactivity.

• Cortisol Elevation and CRH Stimulation – McEwen, B. S. (2007). “Physiology and neurobiology of stress and adaptation: Central role of the brain.” Physiological Reviews, 87(3), 873–904.

McEwen’s review discusses how chronic stress and increased CRH/cortisol levels affect brain function, reinforcing states of vulnerability and dependency.

3. Cognitive Conditioning

• Hippocampal Interference and Memory Reconsolidation – Nader, K., Schafe, G. E., & LeDoux, J. E. (2000). “Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval.” Nature, 406(6797), 722–726.

This paper highlights the disruption of memory reconsolidation, supporting the concept that interference in hippocampal processing can lead to memory distortion.

• Memory Distortion and Neural Plasticity – Brunet, A., et al. (2008). “Reducing PTSD symptoms with reconsolidation blockade using propranolol: A randomized controlled trial.” American Journal of Psychiatry, 165(6), 751–758.

This trial illustrates how propranolol can alter memory reconsolidation, which is analogous to the drug’s proposed mechanism for weakening traumatic memories.

• Dopaminergic Reinforcement and Habit Formation – Robbins, T. W., & Everitt, B. J. (1996). “Neurobehavioural mechanisms of reward and motivation.” Current Opinion in Neurobiology, 6(2), 228–236.

This review provides insight into dopaminergic reinforcement pathways that underlie habit formation and learned behaviors.

4. Delivery Mechanisms

• Olfactory Absorption of Volatile Agents – Frankenhuis, W. E. (1997). “The nose knows: Absorption of airborne substances.” In Environmental Toxicology (pp. 123–139).

This chapter discusses how volatile psychoactive agents can be absorbed via the nasal mucosa, relevant to the proposed olfactory delivery.

• Dermal Penetration and Transdermal Drug Delivery – Prausnitz, M. R., & Langer, R. (2008). “Transdermal drug delivery.” Nature Biotechnology, 26(11), 1261–1268.

This article reviews the principles and technologies behind transdermal drug delivery, providing a basis for sustained-release formulations.

• Ingestion and Slow-Release Formulations – Gabrielsson, J., & Weiner, D. (2007). “Pharmacokinetic and pharmacodynamic modeling of sustained release drug delivery systems.” Pharmaceutical Research, 24(6), 1089–1101.

This paper covers the design and principles of slow-release formulations, analogous to the ingestion method described for cumulative systemic integration.

List of Fandoms and Characters

Ace Attorney: Barok van Zieks

Blue Lock: Jinpachi Ego, Michael Kaiser, Rin Itoshi, Sae Itoshi

Boku no Hero Academia: Dabi, Endeavor, Shouto Todoroki

Brutal: Satsujin Kansatsukan no Kokuhaku: N/A

Death Note: Light Yagami

Demon Slayer: Muzan Kibutsuji

Dishonored Series: Anton Sokolov, Daud

Genshin Impact: Dainsleif, Zhongli (Rex Lapis / Morax)

Haikyuu!!: Kei Tsukishima, Wakatoshi Ushijima

Honkai Star Rail: Blade, Sunday

How to Live as an Illegal Healer: N/A

Hunter x Hunter: Illumi Zoldyck

I'm Not That Kind of Talent: Duke Illuster Starbe, Nemeseus

Jujutsu Kaisen: Kenjaku, Ryomen Sukuna

Kill The Hero: Park Yong-Wan, Se Jun-Lee

Mobile Legends: Bang Bang: Aamon

Naruto Shippuden: Madara Uchiha

One Punch Man: Boros

Reverend Insanity: Fang Yuan

TOUCHSTARVED: N/A

Undertale Multiverse (Human AU): Error! Sans, Ink! Sans, Nightmare! Sans

Wuthering Waves: Geshu Lin

Your Throne: Eros Orna Vasilios

Yandere! Stepfather & Stepdaughter

Novella 1 : Paternal Privilege

He’s your family, but he doesn’t act like it.

🔞Pleasure in every strike, pain in every kiss.

🔞In the end, love is both their salvation and their damnation.

🔞His love is suffocating, but she’s forgotten how to breathe without it.

🔞Love shouldn’t feel like drowning, but he’s the only one who can save her.

She fell, but not by accident. He made sure of it.

Consent is a game he lets you think you’re winning.

♡ A/N #1. I'm not a medical professional, so I just did my own research or this is based on my own notes on books for the past years. Heavy medical terms. I placed both my actual research when writing the story, and a more simple explanation to make things more understandable. Monkey explanation? I just combined different medicines together to form this fictional drug.

♡ A/N #2. Hello, nice to meet you, Anon. I'm glad you enjoyed Paternal Privilege, one of the first R18 series I ever made that really helped in my later writings. You guys really like lore dumps, huh? No worries, some really ask about additional details like this. And I genuinely enjoy world building and lore, it's why I like writing epics as well. For all of you, don't be afraid to ask about additional lore, I really don't mind explaining more about it. However, for this series, I will not be making it a part of the book yet itself. People ask for sequels, so consider this perhaps a minor spoiler then.

♡ A/N #3. I had to dig through so much shiz again to see where my research went. aaghhhh, but at least it's done. I'm so tired, haha. But, hey, free medical lesson. Not a professional but I do my research. A different kind of post, but it's for those who love lore dumps, so here.

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♡ Book 2 [you are here]. Forbidden Fruits (FF): Intimate Obsessions, Unhinged Desires.

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