#Receptor Modulator

[trevlad-sounds]

Invisible Club 036

23.10.2024

Intro 00:00 Oceanographer–Moon Flower 01:24 Parallel Worlds–Just Strange 06:40 Nacht Plank & Futuregrapher–Sky High 9.06 10:10 The Home Current–Mini Drifter 16:03 Receptor Modulator–Invade 19:35 Battaglia–Fight 26:23 Psycho Kick–Black sky 27:19 Bernard Grancher–Courir pour rire 30:46 Gaudi Kosmisches Trio–Luxury Squat 36:04 gribbles–Childer 43:07 Aerophobia–RT. Corps 46:13 Town and County–Salcombe Surge 50:13 Peltiform–Jitr ft. Room of Wires 54:24 Garber–First Contact 58:35 Tadhe–Unwanted Evil 1:06:15 Kayla Painter–Ice Shells 1:11:06 Outro 1:15:22

[faaun]

not 2 be like im gonna cry but 🤪

[healthlineonline]

Buy Tamodex to Regulate Estrogenic Impacts in Steroid Cycles

Tamoxifen is a selective estrogen receptor modulator marketed under the brand name Nolvadex. This is one popularly used anti-estrogen endocrine therapy to cure breast cancer. Tamoxifen citrate is produced with a mixture of pure tamoxifen and citrate acid. Apart from its medical uses, tamoxifen citrate is also used in the bodybuilding grounds for its ability to prevent estrogenic side effects such as water retention, and gynecomastia.

[omg-erika]

The Osteoporosis Hoax

by Dr.Harald Wiesendanger– Klartext What the mainstream media is hiding One in five women over 50 already have osteoporosis – their bone density has decreased dangerously, and there is a risk of fractures. However, conventional treatment only reliably benefits pharmaceutical companies, doctors’ practices, and clinics, and it often worsens the situation of those affected. Simple measures could…

[diet2all]

#Testolone #קוביעזרא #פיתוחגוף ראד 140, טסטולון, סארמס RAD 140, testosterone, selective androgen receptor modulator, SARM, RAD 140 תופעות לוואי, Rad 140 חוות דעת, אפנן קולטן אנדרוגן סלקטיבי, קובי עזרא. טסטולון הוא כימיקל הידוע כמאפנן קולטן אנדרוגן סלקטיבי (SARM). המחקה את פעילות הטסטוסטרון בגוף. אנשים משתמשים בטסטולון כדי לשפר ביצועים אתלטיים ��חוזק שרירים, לסרטן השד ולמטרות אחרות, אך אין הוכחות מדעיות טובות לתמוך בשימושים אלו. טסטולון אינו חוקי בתוספי תזונה בארה"ב. טסטולון נאסר לשימוש ע"י הסוכנות העולמית למלחמה בסמים (WADA) ואיגוד האתלטיקה הלאומי (NCAA). טסטולון עלול להוביל לתופעות לוואי, אציין שהי�� דיווחים על התקף לב ופגיעה בכבד לאחר השימוש. #ראד140 #טסטולון #Testolone #סארמס

[reasonsforhope]

"People living with diabetes might have a new hope. Scientists have tested a new drug therapy in diabetic mice, and found that it boosted insulin-producing cells by 700% over three months, effectively reversing their disease.

Beta cells in the pancreas have the important job of producing insulin in response to blood sugar levels, but a hallmark of diabetes is that these cells are either destroyed or can’t produce enough insulin. The most common treatment is regular injections of insulin to manage blood sugar levels.

But a recent avenue of research has involved restoring the function of these beta cells. In some cases that’s started with stem cells being coaxed into new beta cells, which are then transplanted into patients with diabetes. Researchers behind this kind of work have described it as a “functional diabetes cure.”

Now, scientists at Mount Sinai and City of Hope have demonstrated a new breakthrough. Previous studies have mostly involved growing new beta cells in a lab dish, then transplanting them into mice or a small device in humans. But this new study has been able to grow the insulin-producing cells right there in the body, in a matter of months.

The therapy involved a combination of two drugs: one is harmine, a natural molecule found in certain plants, which works to inhibit an enzyme called DYRK1A found in beta cells. The second is a GLP1 receptor agonist. The latter is a class of diabetes drug that includes Ozempic, which is gaining attention lately for its side effect of weight loss.

The researchers tested the therapy in mouse models of type 1 and 2 diabetes. First they implanted a small amount of human beta cells into the mice, then treated them with harmine and GLP1 receptor agonists. Sure enough, the beta cells increased in number by 700% within three months of the treatment. The signs of the disease quickly reversed, and stayed that way even a month after stopping the treatment.

“This is the first time scientists have developed a drug treatment that is proven to increase adult human beta cell numbers in vivo,” said Dr. Adolfo Garcia-Ocaña, corresponding author of the study. “This research brings hope for the use of future regenerative therapies to potentially treat the hundreds of millions of people with diabetes.”

The results are intriguing, but of course being an animal study means there’s still much more work to be done before it could find clinical use. So far, harmine alone has recently undergone a phase 1 clinical trial in humans to test its safety and tolerability, while other DYRK1A inhibitors are planned for trials in humans next year.

Perhaps most importantly, the team will soon experiment with combining beta-cell-regenerating drugs with others that modulate the immune system. Ideally this should help overcome a major hurdle: the immune system will continue attacking new beta cells as they’re produced.

The research was published in the journal Science Translational Medicine."

-via New Atlas, July 14, 2024

[jessicalprice]

culture isn’t modular

I did a thread (actually several) on Twitter a few years ago about Christianity’s attempts to paint itself as modular, and I’ve been seeing them referenced here in the cultural christianity Discourse, and a few people have DMed me asking me to post it here, so here’s a rehash of several of those threads:

A big part of why Christian atheists have trouble seeing how culturally Christian they still are is that Christianity advertises itself as being modular, which is not how belief systems have worked for most of human history. 

A selling point of Christianity has always been the idea that it's plug-and-play: you don't have to stop being Irish or Korean or Nigerian to be Christian, you don't have to learn a new language, you keep your culture. 

And you’re just also Christian.

(You can see, then, why so many Christian atheists struggle with the idea that they’re still Christian--to them, Christianity is this modular belief in God and Jesus and a few other tenets, and everything else is... everything else. Which is, not to get ahead of myself, very compatible with some tacit white supremacy: the “everything else” is goes unexamined for its cultural specificity. It’s just Normal. Default. Neutral.)

Evangelicals in particular love to contrast this to Islam, to the idea that you have to learn Arabic and adopt elements of Arab culture to be Muslim, which helps fuel the image of Islam as a Foreign Ideology that's taking over the West.

The rest of us don’t have that particular jack

Meanwhile, Christians position Christianity as a modular component of your life. Keep your culture, your traditions, your language and just swap out your Other Religion Module for a Christianity Module.

The end game is, in theory, a rainbow of diverse people and cultures that are all one big happy family in Christ. We're going to come back to how Christianity isn't actually modular, but for the moment, let's talk about it as if it had succeeded in that design goal. 

Even if Christianity were successfully modular, if it were something that you could just plug in to the Belief System Receptor in a culture and leave the rest of it undisturbed, the problem is most cultures don't have a modular Belief System Receptor. Spirituality has, for the entirety of human history, not been something that's modular. It's deeply interwoven with the rest of culture and society. You can't just pull it out and plug something else in and have the culture remain stable.

(And to be clear, even using the term “spirituality” here is a sop to Christianity. What cultures have are worldviews that deal with humanity’s place in the universe/reality; people’s relationships to other people; the idea of individual, societal, or human purpose; how the culture defines membership; etc. These may or may not deal with the supernatural or “spiritual.”)

And so OF COURSE attempting to pull out a culture's indigenous belief system and replace it with Christianity has almost always had destructive effects on that culture.

Not only is Christianity not representative of "religion" full stop, it's actually arguably *anomalous* in its attempt to be modular (and thus universal to all cultures) rather than inextricable from culture.

Now, of course, it hasn't actually succeeded in that--the US is a thoroughly Christian culture--but it does lead to the idea that one can somehow parse out which pieces of culture are "religious" versus which are "secular". That framing is antithetical to most cultures. E.g. you can't separate the development of a lot of cultural practices around what people eat and how they get it from elements of their worldview that Christians would probably label "religious." But that entire *framing* of religious vs. secular is a Christian one.

Is Passover a religious holiday or a secular one? The answer isn't one or the other, or neither, or both. It's that the framing of this question is wrong.

And Christianity isn’t a plugin, however much it wants to be

Moreover, Christianity isn't actually culture-neutral or modular. 

It's easy for this to get obscured by seeing Christianity as a tool of particular cultures' colonialism (e.g. the British using Christianity to spread British culture) or of whiteness in general, and not seeing how Christianity itself is colonial. This helps protect the idea that “true” Christianity is good and innocent, and if priests or missionaries are converting people at swordpoint or claiming land for European powers or destroying indigenous cultures, that must be a misuse of Christianity, a “fake” or “corrupted” Christianity.

Never mind that for every other culture, that culture is what its members do. Christianity, uniquely, must be judged on what it says its ideals are, not what it actually is. 

Mistaking the engine for the exhaust

But it’s not just an otherwise innocent tool of colonialism: it’s a driver of it. 

At the end of the day, it’s really hard to construct a version of the Great Commission that isn’t inherently colonial. The end-goal of a world in which everyone is Christian is a world without non-Christian cultures. (As is the end goal of a world in which everyone is atheist by Christian definitions.)

Yet we focus on the way Christianity came with British or Spanish culture when they colonized a place--the churches are here because the Spaniards who conquered this area were Catholic--and miss how Christianity actually has its own cultural tropes that it brings with it. It's more subtle, of course, when Christianity didn't come in explicitly as the result of military conquest.

Or put another way, those cultures didn't just shape the Christianity they brought to places they colonized--they were shaped by it. How much of the commonality between European cultures is because of Christianity?

It’s not all a competition

A lot of Christians (cultural and practicing), if you push them, will eventually paint you a picture of a very Hobbesian world in which all religions, red in tooth and claw, are trying to take over the world. It's the "natural order" to attempt to eliminate all cultures but your own. 

If you point out to them that belief and worldview are deeply personal, and proselytizing is objectifying, because you're basically telling the person you're proselytizing to that who they are is wrong, you often get some version of "that's how everyone is, though."

Like we all go through life seeing other humans as incomplete and fundamentally flawed and the only way to "fix" them is to get them to believe what we believe. And, like, that is not how everyone relates to others?

But it's definitely how both practicing Christians and Christian antitheists relate to others. If, for Christians, your lack of Jesus is a fundamental flaw in you that needs to be fixed, for New Atheists, your “religion” (that is, your non-Christian culture) is a fundamental flaw in you that needs to be fixed. Neither Christians nor New Atheists are able to relate to anyone else as fine as they are. It's all a Hobbesian zero-sum game. It's all a game of conversion with only win and loss conditions. You are, essentially, only an NPC worth points.

The idea of being any other way is not only wrong, but impossible to them. If you claim to exist in any other way, you are either deluded or lying.

So, we get Christian atheists claiming that if you identify as Jewish, you can’t really be an atheist. Or sometimes they’ll make an exception for someone who’s “only ethnically Jewish.” If the only way you relate to your Jewishness is as ancestry, then you can be an atheist. Otherwise, you’re lying. 

Or, if you’re not lying, you’re deluded. You just don’t understand that there’s no need for you to keep any dietary practices or continue to engage in any form of ritual or celebrate any of those “religious” Jewish holidays, and by golly, this here “ex”-Christian atheist is here to separate out for you which parts of your culture are “religious” and which ones are “secular.”

Religious/secular is a Christian distinction

A lot of atheists from Christian backgrounds (whether or not they were raised explicitly Christian) have trouble seeing how Christian they are because they've accepted the Christian idea that “religion” is modular. (If we define “religion” the way Christians (whether practicing or cultural) define it, Christianity might be the only religion that actually exists. Maybe Islam?)

When people from non-Christian cultures talk about the hegemonically Christian and white supremacist nature of a lot of atheism, it reflects how outside of Christianity, spirituality/worldview isn't something you can just pull out of a culture.

Christian atheists tend to see the cultural practices of non-Christians as "religious" and think that they should give them up (talk to Jewish atheists who keep kosher about Christian atheist reactions to that). But because Christianity positions itself as modular, people from Christian backgrounds tend not to see how Christian the culture they imagine as "neutral" or "normal" actually is. In their minds, you just pull out the Christianity module and are left with a neutral, secular society.

So, if people from non-Christian backgrounds would just give up their superstitions, they'd look the same as Christian atheists. 

Your secularism is specifically post-Christian

Of course, that culture with the Christianity module pulled out ISN'T neutral. So the idea that that's what "secular society" should look like ends up following the same pattern as Christian colonialism throughout history: the promise that you can keep your culture and just plug in a different belief system (or, purportedly, a lack of a belief system), which has always, always been a lie. The secular, "enlightened" life that most Christian atheists envision is one that's still built on white, western Christianity, and the idea that people should conform to it is still attempting to homogenize society to a white Christian ideal. 

For people from cultures that don't see spirituality as modular, this is pretty obvious. It's obvious to a lot of people from non-white Christian cultures that have syncretized Christianity in a way that doesn't truck with the modularity illusion. 

I also think, even though they're not conceptualizing it in these terms, that it's actually obvious to a lot of evangelicals. (The difference being that white evangelical Christianity enthusiastically embraces white supremacy, so they see the destruction of non-Christian culture as good.) But I think it's invisible to a lot of mainline non-evangelical Christians, and it's definitely invisible to a lot of people who leave Christianity.

And that inability to see culture outside a Christian framing means that American secularism is still shaped like Christianity. It's basically the same text with a few sentences deleted and some terms replaced.

Which, again, is by design. The idea that you can deconvert to (Christian) atheism and not have to change much besides your opinions about God is the mirror of how easy it’s supposed to be to convert to Christianity.

Human societies don’t follow evolutionary biology

The Victorian Christian framing underlying current Western ideas of enlightened secularism, that religious practice (and human culture in general) is subject to the same sort of unilateral, simple evolution toward a superior state to which they, at the time, largely reduced biological evolution, is deeply white supremacist.

It posits religious evolution as a constantly self-refining process from "primitive" animism and polytheism to monotheism to white European/American Christianity. For Christians, that's the height of human culture. For ex-Christians, the next step is Christian-derived secularism.

Maybe you’ve seen this comic?

The thing is, animism isn’t more “primitive” than polytheism, and polytheism isn’t more “primitive” than monotheism. Older doesn’t mean less advanced/sophisticated/complex. Hinduism isn’t more “primitive” than Judaism just because it’s polytheistic and Judaism is monotheistic. 

Human cultures continue to change and adapt. (Arguably, older religions are more sophisticated than newer ones because they’ve had a lot more time to refine their practices and ideologies instead of having to define them.) Also, not all cultures are part of the same family tree. Christianity and Islam may be derived from Judaism, but Judaism and Hinduism have no real relationship to one another. 

But in this worldview, Christianity is "normal" religion, which is still more primitive than enlightened secularism, but more advanced than all those other primitive, superstitious, irrational beliefs.

Just like Christians, when Christian atheists do try to make room for cultures that aren't white and European-derived, the tacit demand is "okay, but you have to separate out the parts of your culture that the Christian sacred-secular divide would deem 'religious.'"

Either way, people from non-Christian cultures, if they’re to be equals, are supposed to get with the program and assimilate.

You’re not qualified to be a universal arbiter of what culture is good

Christian atheists usually want everyone to unplug that Religion module!

So, for example, you have ex-Christian atheists who are down with pluralism trying to get ex-Christian atheists who aren't to leave Jews alone by pointing out that you can be atheist and Jewish.

But some of us aren’t atheist. (I’m agnostic by Christian standards.) And the idea that Jews shouldn’t be targets for harassment because they can be atheists and therefore possibly have some common sense is still demanding that people from other cultures conform to one culture’s standard of what being “rational” is.  

Which, like, is kind of galling when y’all don’t even understand what “belief in G-d” means to Jews, and people from a culture that took until the 1800s to figure out that washing their hands was good are setting themselves up as the Universal Arbiters of Rationality.

(BTW, most of this also holds true for non-white Christianity, too. I guarantee you most white Christian atheists don’t have a good sense of what role church plays in the lives of Black communities, so maybe shut up about it.)

In any case, reducing Christianity--a massive, ambient phenomenon inextricable from Western culture--to the specific manifestation of Christian practice that you grew up with is, frankly, absurd. 

And you can’t be any help in deconstructing hegemony when you refuse to perceive it and understand that it isn’t something you can take off like a garment, and you probably won’t ever recognize and uproot all the ways in which it affects you, especially when you are continuing to live within it. 

What hegemony doesn’t want you to know

One of the ways hegemony sustains and perpetuates itself is by reinforcing the idea not so much that other ways of being and knowing are evil (although that’s usually a stage in an ideology becoming hegemonic), but that they’re impossible. That they don’t actually exist. 

See, again, the idea that anyone claiming to live differently is either lying or deluded.

There are few clearer examples of how pervasive Christian hegemony is than Christian atheists being certain every religion works like Christianity. Hegemonic Christianity wants you to think that all cultures work like Christianity because it wants their belief systems to be modular so you can just ...swap them. And it wants to pretend that culture/worldview is a free market where it can just outcompete other cultures.

But that’s... not how anything works. 

And the truth of the matter is that white nationalist Christians shoot at synagogues and Sikh temples and mosques because those other ways of being can’t be allowed to exist. 

They don’t shoot at atheist conventions because there’s room in hegemonic Christianity for Christian atheists precisely because Christian atheists are still culturally Christian. Their atheism is Christian-shaped.

They may not like you. They’re definitely going to try to convert you. They may not want you to be able to hold public office or teach their kids.

But the only challenge you’re providing is that of The Existence of Disbelief. And that’s fine. That makes you a really safe Other to have around. You can See The Light and not have to change much.

What you’re not doing is providing an example of a whole other way of being and knowing that (often) predates Christianity and is completely separate from it and has managed to survive it and continue to live and thrive (there’s a reason Christians like to speak of Jews and Judaism in the past tense, and it’s similar to the reason white people like to speak of indigenous peoples of the Americas in the past tense). 

That’s not a criticism--it’s fine to just... be post-Christian. There’s not actually anything wrong with being culturally Christian. The problems come in when you start denying that it’s a thing, or insisting that you, unique among humankind, are above Having A Culture.

But it does mean that you don’t pose the same sort of threat to Christianity that other cultures do, and hence, less violence. 

[tinydefector]

Is it too much to ask for a follow-up on the Human' Effects fic?

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Masterlist

This is more just some more information of headcanons I have and how I like writing the bots. So I hope you enjoy it. This one's more on the differences and similarities between humans and Cybertronians.

Word count: 2.5k

Warning: mentions of reproduction, and exploration of body's. Valveplug.

__________

So this is just a continuation for Human effects. This one also delves into some more information on biological, cultural and different frames and how they interact with each other, humans and other organic Creatures. 

Biological Humans and Cybertronians are vastly different even with quite a few similarities. 

Sparklings and children 

There is a very big difference in the body function of Humans and Cybertronians. Size for one but also Organic DNA and CNA. There are many things which can Line up with the other species but also function very differently 

Such as. 

structure and organ comparison 

Plating - skin

Helm - head

Processor, brain module - brain 

Faceplate- face

Audio Receptors, Audials, Receptor orifices - ears 

Nasal ridge, enstril, olfactory sensors- nose

Optical ridge - eyebrows

Optics, visors  - eyes and glasses sometimes visors are used as optics

Intake- mouth, throat or a breath. 

Denta, denta plating- teeth 

Glossa- tongue 

Mandibles (insecticons) - jaw 

Vocalizer- voice box 

Chin or chin plating are the same 

Chestplate, chassis- chest and higher stomach (abs area) 

Fuel tanks- stomach. 

Backplate, back struts, binary system,  bipedalism - back and spine, spinal cord. 

Servos and digits - Hands and fingers 

Sounder plating - shoulder blades 

Pede - feet 

pump and Spark - heart and soul 

Energon lines - arrays veins. 

Vents - lungs, breath. 

Pelvic plate - pelvis

Aft, tailpipe, skid plate- butt

Interface panel - covered reproduction organs

Spike - penis 

Value - vagina 

Carrier chamber, Gestation chamber - womb

Helm and head

With the fact one is filled with circuitry, coding and wires and the other is filled with flesh, fluid and other organic matter. Humans' heads are covered in hair most times. And even those who aren't their head Is still rather soft and smooth. And the bots love playing with human hair and facial hair when they are allowed too. 

It also leads to humans giving the bots head scratches, and it's something so man you the bots had never thought of and they love it. They will lay their head in their human lap and just enjoy the gentle touches to their Finial, audials, and helm crest. It becomes. Causal thing of the humans using soft little microfiber cloths to clean out dust and dirt from the small crevices in the bots Plating. Head pats and scratches really becomes something that Cybertronians love alot and it makes a lot of humans consider the bots large cats.

Faceplate and Faces. 

One of the things which is very different between humans and Cybertronians is how they show affection to each other. Cybertronians do a thing called a helm hold. Where they each hold their partner's helm in their servos while looking into each other's optics, it's how they show how much they care, because they are focusing only on that one person. And it means alot more after the war, to focus all your attention on just one bots servos shows a lot of trust, affection and love for someone.  

While humans have Hugging, kissing. So the bots are rather confused the first time they are hugged, tensing up not wanting to hurt their human. And they nearly short circuit when the human kisses them it's more out of fear. 

“Do you know how dangerous that is! What if I crushed you!” The bot hisses in panic while looking at their lover. “not to mention the fact that is my Energon Intake! Do you know what energon can do to Humans!” It nearly sends the bot into meltdowns as they hold their lover's face staring into their eyes trying to show them how much they love and care for them. It would break their spark if they accidentally hurt them. 

“it's called a Kiss, I was kissing you” the human tries to explain, their hands cupping around their bots servos. 

“a kiss?” the bot inquired. “Yea I'm sorry if you didn't want it, it's just I thought we were in that part of our relationship” the human begins rambling out of anxiety thinking they had messed up. In the end they both settle for a small gesture in-between. Pressing their head and helm, together as they cradle the other. 

Eventually they will come around to accepting kisses but it is only for very special occasions. Because the bot will make sure that there isn't a trace of energon in their system for their partner's safety. Over time it becomes them pressing soft kisses to each other's noses. 

Skin and Plating 

These are all the parts which somewhat are similar to humans, but also work vastly different than the human body does. So with this listed here are many of the things that vary with the similarities. 

Plating and skin are vastly different due to one being metal and the other being flesh, it's one of the things a lot of the Cybertronians love is how soft Human skin is. They really enjoy just fondling their human companions, pulling their checks, and enjoying how their skin moves. How pliable, warm and squishy they are. Cybertronians finding out about human breasts really takes them by storm. 

“What are those?” the bot asks while pressing a finger to their breast feeling how soft and squishy they are. 

“breast, boobs, tits they have a lot of names” 

“What are they for?” The bot continues to just slowly play with them out of curiosity, not knowing what the human would need them for. 

“they are used for feeding babies, they fill with milk, it's not a constant thing and not everyone's do but they are for feeding babies.” the human tries to explain and it just leaves the bot shocked. 

“You're with Sparkling?” The bot asked as they began fussing over the human more, gently pressing their digits to the human's body more. 

“no, no I'm not pregnant!” They laugh out loud while rather embarrassed. “‘but wouldn't they deflate?” The bot shoots back as their digits begin needing the flesh which makes the humans sigh and lean into the touch. “human babe, don't have the same functions as you.” They tease softly.

 It ends up with one bot having their human lover back pressed to their Chassis. The bot's servos just cupped around their partners breast slowly massaging them as the human leans back just enjoying the feeling because it takes the weight off their back and the cool touch of the metal feels delightful against their skin. 

Heart and spark

The difference between a human heart and spark aren't that different at all. They both pump blood/energon to where it's needed, it's the life provider of the body. Each has a beat or pulse. And the said beat and pulse sounds different. A human's heart beat feels like a thump but to Cybertronians it's an echo. Each beat they can feel and see like A beating light. And they love how it feels laying against them, their spark will actually fall in tune With their heart beat as a way to calm the human.  While for humans a Cybertronians spark pulse feels like electricity dancing across their skin it's like the build up of static but it doesn't zap. The vibration of a spark is like energy building and releasing, the buzzing sound that just resonates through their body as they lay against their bot. 

olfactory sensors and nose

Unfortunately humans don't have the enhanced scent sensors that a lot of other species do, and Cybertronians have one for the most advanced ones, they don't just smell it but they can break down the chemical compound to its base and are able to tell humans emotions based on how they smell. It also leads to bots becoming rather touching with their lovers when they can smell their cycle. It also leads a lot of bots realising they have a breeding kink after being with a human, because the moment they can feel their partners change in hormones they are hovering. It becomes an even bigger thing when they smell the scent of a young spark, they feel the EM Field. 

carriers and pregnancy 

There is a major difference between human pregnancy and cybertronian pregnancy. Humans can only be born from reproduction.  a new spark can be formed in multiple ways. 

-Forged.  

-Cold construct. 

-split spark

- Sparked 

Forged new sparks are bots that are formed in hotspots across cybertron and on occasions sparklings can also be formed from these hot spots. 

Cold constructs are bots that have been made by others for a purpose and were originally classed as 2nd class citizens, miners or lower than other bots, 

Split Sparks made from splitting your spark into another form. It was very rare due to multiple laws being inplace against it. 

Sparklings were formed through spark merging with another and creating enough energy to form new lifeforms. A carrier would then have to host said spark in their Gestation chamber until the spark could grow its own protoform. Then from there they are moved into the carrier chamber where they learn off their carrier's coding, and also receive food, coding and personal information from their Sire via Transfluid. As sparklings are still not able to consume normal energon and it has to be processed down enough for the sparkling. (Similar to how humans breastfeed) from there once they are ready the sparkling will be ‘birthed’ and from their they will need to be carried in a spark chamber until they have fully developed but gives them time to learn the world around them but still have the safety of a parent to protect them. 

This leads the bots and humans to both be horrified at the differences of the others' reproduction. The bots are horrified over the fact a human's pelvis bone breaks just to birth a baby. But also the fact that humans can carry more than one child. They eventually watch a documentary over human birth; it makes a lot of bots short out and crash. 

Humans on the other hand are shocked over the time it takes for a bot to have a sparkling. 100 years is longer than a lot of humans ever live but it's how long it takes for the full process of a sparkling to be formed and born. That's without all the issues with CNA, temperature, spark energy, energon. A Lot of Cybertronian pregnancies don't make it to term due to these factors. 

So when by some chance a human gets pregnant by a Cybertronian it has the whole planet up in a tissy. Not just the fact of how genetically different they are but how it happened. The first human Cybertronian sparkling is a miracle watched by man and documented. And it turns out the human womb is actually the best possible hosting spot for the start of a sparkling, it's the perfect temperature, and it's not a temperature a lot of bots can keep their own frames. The human womb actually short cuts a lot of time over the birth Due to the sparkling Not needing to be shifted from one chamber to another. It comes down to being pregnant for 3 years. It's a long time for a human but it's decades Less than what it normally takes for a Cybertronian if they made it through the full progress. 

And when the sparkling is born it's discovered that the sparkling doesn't have any human traits, defects or appearance. Due to the human body mainly working as a host, the CNA and DNA don't mix when it comes to creating a sparkling but they work perfectly in sync When it comes to helping the sparkling grow. And it also turns out humans are able to sustain more than One sparkling. 

That also brings me to the function of spike and Valves. For Cybertronians spikes and Valves aren't how Sparklings are created, sparklings are created from two sparks merging together and creating enough energy for a sparkling but interface is needed to start the process of how they form. Sparkling needs Transfluid to begin and that is what Cybertronians use interfacing for outside of sharing memories, information and emotions. Most times Cybertronians interface for fun, feeling close, sharing information with a loved one, or to help feed a sparkling the necessary data, fluids and programming. 

so When a Cybertronian and human interface it has a lovely mix of a 50/ 50 chance of getting pregnant due to how the human and cybertronian heart and spark link in a frequency that is almost essential Spark merging. And a human doesn't even need to interface with a Cybertronian to get pregnant.

Here is a list of ways humans have gotten pregnant/ a bot has gotten pregnant. 

-interfacing 

-spark bonding 

-a human touching a bots spark. 

-having enough hated for another you get them pregnant by sheer Anger

- spark And heart syncing 

-A human being on their cycle will make a bot pregnant. 

______________

Megatron entered the medbay of the Lost Light, feeling unusual warmth and pressure in his chest. "Ratchet," he said gruffly to get the medic's attention. "Something is...off. I feel as if I have consumed fool's energon again, but I know that is not the case." 

He looked down at the medic, his optics betraying slight concern beneath his usual stern demeanour. "Examine me and determine what ails me. I need to be at full function." His pride did not allow him to admit weakness easily, but he trusted Ratchet's skills. 

Ratchet nodded to First Aid and They as they stood ready to assist. He turned back to Megatron with a scrutinising gaze.

"When did you first notice the symptoms? Any other anomalies in your systems?" he asked gruffly, scanning the Decepticon warlord from head to foot with a diagnostic tool. The scans showed unusual activity in Megatron's Gestation chamber.

"Hmm...it appears your spark is pulsing more rapidly than normal. And the pressure you described suggests a buildup of energon flow." Ratchet paused, analysing the data. "This could indicate...no, it's not possible. Or is it...?" He leaned in closer, inspecting Megatron with keen optics.

"We'll need a more detailed scan. Over here, lay back - this won't hurt but may feel peculiar. First Aid, fire up the resonator. Ambulon you're in charge of monitoring vitals."

"What's wrong, ratchet he was fine this morning?" The human asked in concern. 

Megatron lay back on the medical berth as directed, his massive frame dwarfing its size. his expression softened ever so slightly. As the detailed spark scan began, Ratchet's optics widened in surprise. "By the Allspark...it can't be..." He motioned First Aid "Look here. What do you see?"

First Aid peered at the monitor in amazement. "Two distinct spark pulses...but how is that possible?" Ratchet glanced over at Megatron, then back at the others. "It would seem Megatron himself is carrying sparkling. The increased energon flow and pressure were signs of protoform development beginning."

He chuckled wryly. "Well Megatron, it seems that fool's energon was not to blame after all. Congratulations...you're going to be a creator." Megatron's optics widened in disbelief at Ratchet's announcement. Carrying sparkling? It made no sense as far as he knew, spark merging could only occur between cybertronians and he had only been intimate with a human. 

He sat up abruptly, almost knocking First Aid over, and glared down at Ratchet. "Explain yourself, medic! How is this possible? The human and I have been intimate but they clearly lack our means of conception." Ratchet held up a calming hand. "Peace, Megatron. I have a theory," 

Taglist: @angelxcvxc

@ladyofnegativity

[covid-safer-hotties]

Also preserved in our archive (Daily updates!)

There've been a lot of studies showing vitamin D deficiency in people with mild to severe covid cases. A new meta-analysis probes into the possible connections and effects of vitamin D during acute covid infections.

By Dr. Liji Thomas, MD

New study suggests vitamin D supplementation may lower ICU and intubation rates in COVID-19 patients, with greater benefits seen in older and severe cases.

The impact of vitamin D on the progression of COVID-19 remains uncertain. A recent meta-analysis in Nutrients reviewed studies on vitamin D supplementation in COVID-19 patients to assess its effectiveness in reducing disease severity across various health metrics.

Why is vitamin D important? Vitamin D is essential for bone health, but its influence extends far beyond, as its receptor is present in all nucleated human cells. This receptor regulates nearly 4% of human genes, impacting many physiological processes, including cancer development, muscle function, cardiovascular health, glucose balance, and immune response to infections and autoimmune reactions.

With the onset of the SARS-CoV-2 pandemic, there was significant interest in whether vitamin D could reduce the severity or spread of COVID-19. Vitamin D plays a role in immunity by lowering the release of pro-inflammatory cytokines, boosting antimicrobial peptides, supporting epithelial barriers, and modulating T-cell activity—mechanisms that may help prevent the severe hyperinflammation associated with critical COVID-19 cases and high mortality.

This study investigates the protective effects of vitamin D supplementation during COVID-19, used alongside standard treatments like glucocorticoids, anticoagulants, and antivirals, as recommended in current care guidelines.

About the study The researchers included 21 randomized controlled trials (RCTs) and eight analytical studies in the meta-analysis. Of these, mortality rates were examined in 19 RCTs and seven analytical studies, intensive care unit (ICU) admissions in 14 and five, respectively, intubation rates in nine and three, respectively, and the length of hospital stay (LOS) only in RCTs.

Vitamin D dosage varied considerably between studies, both in intervention and control groups.

Vitamin D and ICU admissions In the randomized controlled trials (RCTs), vitamin D supplementation demonstrated a stronger protective effect at higher doses compared to lower doses. Specifically, higher doses were associated with a 63% reduction in ICU admission rates compared to lower doses.

ICU admissions decreased by 57% among patients aged 65 or older and by 44% among those under 65. Patients with severe disease did not show a significant response to vitamin D, while those with non-severe disease experienced 33% fewer ICU admissions.

Intubation rates Intubation rates fell by 50% in RCTs. The lack of effect in analytical studies may have been because they were carried out only in non-severe older COVID-19 patients and were limited in number.

The tendency towards significance strengthens the hypothesis of the benefit of vitamin D in reducing the need for intubation during COVID-19.

Mortality rates Mortality rates showed significant differences in the vitamin D supplementation group but only in analytical studies, with a fall of 55%. This might indicate a tendency to bias in analytical studies.

Despite the overall lack of significance, age-stratified analysis of the RCTs showed a 42% reduction in mortality in older patients but not those <65 years. The authors suggested that the overall analysis might have failed to reveal these more granular effects.

Another interesting effect was that vitamin D supplementation had a more marked mortality-reducing impact in the early months of the pandemic, up to May 2020, than later on.

Finally, the most ill patients had a 50% mortality reduction benefit, but not the less severely ill patients. Thus, mortality analyses in the RCTs present a complex picture, with significant protective effects observable in some subgroups but not in the overall analysis.

LOS Among non-severe COVID-19 patients, vitamin D supplementation was associated with a -0.95-day difference in hospital length of stay. Potential benefits could exist in other groups, but this awaits validation from future research.

The variations between studies should be interpreted as accounting for the forms of vitamin D in use, such as calcifediol or cholecalciferol.

The latter is faster-acting than the former, which may make a difference in acute severe COVID-19, especially as evidence indicates that active vitamin D is used up in the acute response to the infection.

However, broad differences were noted across the studies, including baseline vitamin D levels, dosages, and duration of symptoms before vitamin D supplementation. Still, the findings agree with some previous analyses, with a more nuanced conclusion.

Conclusions The findings do indicate that vitamin D supplementation could be of benefit in COVID-19 treatment, reducing ICU admissions, mortality, and intubation requirements. All studies showed fewer ICU admissions in the intervention group.

“The differing effects based on age, disease severity, and possibly baseline vitamin D status highlight the need for a nuanced approach to vitamin D supplementation in COVID-19 management.”

The greatest effect seems to be in reducing ICU admissions. Still, with differences in the evidence across various patient subgroups and for different outcomes, there is a need for larger trials with a better design that adjusts for baseline vitamin D levels and uses standardized dosages and regimens, as well as compensating for patient characteristics.

Journal reference: Sartini, M., Puente, F. D., Carbone, A., et al. (2024). The Effect of Vitamin D Supplementation Post COVID-19 Infection and Related Outcomes: A Systematic Review and Meta-Analysis. Nutrients. doi: doi.org/10.3390/nu16223794. www.mdpi.com/2072-6643/16/22/3794.

[thoughtportal]

In eastern Mexico’s underground caverns and streams, a blind fish undergoes a peculiar adolescence: as it approaches maturity, taste buds begin to sprout under its chin and on top of its head, creeping toward its back.

“It’s a pretty wild amplification of the sensory system of taste,” says Josh Gross, an evolutionary geneticist at the University of Cincinnati and a co-author of a recent study on the cave fish in Nature Communications Biology. Gross and his team discovered that the new buds blossom around the time when the fish transition from eating larval crustaceans to gobbling up their adulthood staple: bat guano. Taste buds outside their mouths might be helping the fish detect bat droppings in the utterly dark, “food-starved” caves, Gross says.

Wandering taste buds aren’t unheard of elsewhere, especially in other fish. Some damselfish cultivate taste buds on their fins, and channel catfish have them across their midsections. And as alien as it may seem, many cells throughout the human body can taste, too. They’re just not sharing the flavors with your brain like taste buds do.

Lora Bankova is a Harvard Medical School respiratory biologist who studies tuft cells, a cell type sprinkled within human mucous tissues like those lining your nostrils, throat and gut. These “rapid responder” cells trigger the immune system if they detect an outside threat, and many of them rely on built-in taste receptors (the same kinds found on taste-bud cells) to do so. Bankova notes that many potentially harmful bacteria communicate via signaling chemicals called lactones—which also happen to activate taste receptors attuned to bitter flavors, prompting tuft cells’ immune response. And it turns out that even environmental allergies may be a matter of taste: dust mites and several mold species can also set off a tuft cell’s taste receptors, Bankova says.

“Evolutionarily, taste receptors [have moved around] the body to protect us from the air we inhale and all the attacks we’re getting through the orifices,” Bankova says. “They’re in the inner ear, the urethra, everywhere something can get into your body.”

Such “extra” taste receptors aren’t just bouncers at the door—they taste test for our internal systems, too. Receptors for sweet tastes help to tune insulin production in the pancreas and make sure neurons in the brain have access to enough glucose. Sweet, bitter and umami receptors in the gut modulate digestion.

Gross says it’s still a mystery what taste receptors the bat guano activates in the blind cave fish. “There may be some sugar content if it’s a fruit bat, maybe some protein content if it’s a carnivorous bat,” he says. So far only the cave fish has signed up to sample it.

[trevlad-sounds]

Invisible Club 34

09.10.2024

Intro 00:00 Binaural Space–Fractured Beyond Repair 01:17 The Qualitons–Lil’ Bonch 05:57 Receptor Modulator–The oldest model 10:12 Natureboy Flako–Numero Cien 17:33 Scanner–Beginning of an Unknown Century 20:03 Sean Ono Lennon, Devon Hoff, Yuka Honda, Michael Leonhart, João Nogueira, Mauro Refosco, Ches Smith, Johnny Mathar-Starwater 25:30 Cate Brooks–Void Patterns 32:57 Bit Cloudy–Coronation Crack 35:40 Floating Points–Vocoder [Club Mix] 38:46 Pulsliebhaber–Galerina Marginata 46:14 Matt Berry–I Cannot Speak 50:00 Neil Cowley Trio–Adam Alphabet 52:34 Prairiewolf–The Meander 55:48 Cory Wong–Sell By Date 59:29 Furii–Ilk 1:03:58 Hayden Pedigo–Some Kind of Shepherd – Live 1:07:46 Outro 1:12:52

[brightlotusmoon]

The endocannabinoid system (ECS) is a biological system first discovered in the late 1980s and early ’90s. It is largely composed of endogenous cannabinoid molecules (endocannabinoids) together with the receptors they interact with and enzymes that regulate their levels in the body. This simply means that the body produces native molecules which are similar in certain ways to plant cannabinoids like THC and play an important role in our normal biology.

The different pieces of the ECS “work together” to modulate everything from sleep to mood, memory, appetite, reproduction, and pain sensation. Scientists still have plenty of questions about the human endocannabinoid system and how it functions, but there is an overarching principle that the ECS seems to embody within the bodily tissues it helps regulate.

Homeostasis: Staying in the Goldilocks zone

[healthlineonline]

Buy Tamodex Steroid for Bodybuilding

Bodybuilders find Tamodex very helpful because it reduces the effect of estrogen on the body. It blocks estrogen generation in specific areas of the body, so bodybuilders do not face problems like water retention. When combined with other steroids like Clomid, it gives the most effective results.

[humancelltournament]

Propaganda!

A megakaryocyte is a large bone marrow cell with a lobated nucleus that produces blood platelets (thrombocytes), which are necessary for normal clotting. Once the cell has completed differentiation and become a mature megakaryocyte, it begins the process of producing platelets. The maturation process occurs via endomitotic synchronous replication whereby the cytoplasmic volume enlarges as the number of chromosomes multiplies without cellular division. The cell ceases its growth at 4N, 8N or 16N, becomes granular, and begins to produce platelets.

Cytokines are a broad and loose category of small proteins (~5–25 kDa) important in cell signaling. Due to their size, cytokines cannot cross the lipid bilayer of cells to enter the cytoplasm and therefore typically exert their functions by interacting with specific cytokine receptors on the target cell surface. Cytokines have been shown to be involved in autocrine, paracrine and endocrine signaling as immunomodulating agents. They act through cell surface receptors and are especially important in the immune system; cytokines modulate the balance between humoral and cell-based immune responses, and they regulate the maturation, growth, and responsiveness of particular cell populations. Cytokines are important in health and disease, specifically in host immune responses to infection, inflammation, trauma, sepsis, cancer, and reproduction.

[psi-hate]

forcefem this forcefem that. Must we use such blunt force measures? Can't a girl have an 80%+ success rate at convincing "cis" dudes to go on e through persuasion and encyclopedic knowledge of selective estrogen receptor modulators they'll stop taking within the month alone?

^ you rn

don't make me shove u into a locker that turns you into a fox