#NEVER GONNA GIVE YOU UP

[ssb-11]

I... I thought the joke was over.

[yourlocalxiaosimp]

Fuck it I’m bored

I’m gonna tag @same-pic-rick-roll and @thephantomrickroller to try and get this to the right people

[startrekvsfaceapp]

[ganurath]

One of the downsides of using a clock radio alarm to wake up in the morning is the nonzero possibility of waking up to Rick Astley's Never Gonna Give You Up.

[thunder-cube]

[purplerat111]

Please 😔💖

[thephantomrickroller]

I am a fan of your work

THANK YOU MY GOOD SIR!!

[clarablightt]

Rickolas Astley

[cleomigadon]

Durgetash's Greatest Hits!

So did my foot. 🦶🏻

[weirdly-specific-but-ok]

OFFICIAL GOOD OMENS MASCOT HERE. TODAY HAS NOT BEEN A GOOD DAY FOR MY LEGACY. MAYBE I SHOULD JUST. RETIRE.

@wispedvellichor @spookydazechaos THIS IS ON YOU.

[one-time-i-dreamt]

I got rickrolled. I don’t remember anything else besides waking up and having the second half of the song continuing in my head.

[violent138]

Thinking of Bruce, who spent his youth playing guitar loudly, super excited to share that with his super cool crime fighting tragic backstory included child.

Only for Dick to say, "Yeah guitar's cool, you know what's even better?" *pulls out an accordion*

Bruce, over the accordion: "Alfred you still have the receipt for this one right?"

[hellsite-proteins]

I love this idea.

Can you render the lyrics of Never Gonna Give You Up?

i’ve gotten this request several times now, so for anyone who asked for this after uniquepickles you can just look at this post.

enjoy!:

letter sequence in this ask matching protein-coding amino acids:

WerenstrangerstlveYknwtherlesandsdIdIAfllcmmitmentswhatImthinkingfYwldntgetthisfrmanythergyIstwannatellyhwImfeelingGttamakeynderstandNevergnnagiveypNevergnnaletydwnNevergnnarnarndanddesertyNevergnnamakeycryNevergnnasaygdyeNevergnnatellalieandhrtyWeveknwneachtherfrslngYrheartseenachingtyretshytsayitsayitInsidewethknwwhatseengingngingnWeknwthegameandweregnnaplayitAndifyaskmehwImfeelingDnttellmeyretlindtseeNevergnnagiveypNevergnnaletydwnNevergnnarnarndanddesertyNevergnnamakeycryNevergnnasaygdyeNevergnnatellalieandhrtyNevergnnagiveypNevergnnaletydwnNevergnnarnarndanddesertyNevergnnamakeycryNevergnnasaygdyeNevergnnatellalieandhrtyWeveknwneachtherfrslngYrheartseenachingtyretshytsayitsayitInsidewethknwwhatseengingngingnWeknwthegameandweregnnaplayitIstwannatellyhwImfeelingGttamakeynderstandNevergnnagiveypNevergnnaletydwnNevergnnarnarndanddesertyNevergnnamakeycryNevergnnasaygdyeNevergnnatellalieandhrtyNevergnnagiveypNevergnnaletydwnNevergnnarnarndanddesertyNevergnnamakeycryNevergnnasaygdyeNevergnnatellalieandhrtyNevergnnagiveypNevergnnaletydwnNevergnnarnarndanddesertyNevergnnamakeycryNevergnnasaygdyeNevergnnatellalieandhrty

protein guy analysis:

i was really interested to see how this one would turn out, as it is made up almost entirely of repeated domains (the chorus). unfortunately, as many of you may be quick to point out, the chorus of Rick Astley's 'Never Gonna Give You Up' is not in fact a protein domain, and the only thing repeated are some terrible looking loops. i've even included a second picture to properly show you how flat this terrible protein is.

i thought i understood Levinthal's paradox before starting this blog, but these structures are giving me a newfound appreciation. for those who are unaware, Levinthal's paradox is based on the fact that any given protein can fold into an enormous number of possible conformations, but cannot test all of these within the seconds or less that it takes for a protein to fold into its stable tertiary structure. correct folding is controlled by the primary structure (or, the sequence of amino acids encoding the protein) as well as complex factors including the presence of any chaperones to assist with folding, and the relative abundance of the tRNAs matching specific codons for each amino acid. running this blog makes me think of all the ways this process can fail along the way, and all of the almost correct places a protein can get stuck. this one certainly looks like it failed, but even then its hard to believe this is the shape that stuck.

for those interested, the one beta sheet goes with the line 'you wouldn't get this from any other guy', which does only occur once in the song.

predicted protein structure:

[ash5monster01]

was going through pictures on google…..

please who did this, I need someone to fess up immediately 😭

[rolyleritae]

画的never gonna give you up里的一小段

[roundtriptojupiter]

i need everyone to watch this right now. my god. holy shit. ive had it stuck in my head for 3 days. dessert spoons. mr astley what on earth

EDIT: i actually did 2 secs of research & it turns out he made a full new version of the song w/ misheard lyrics as a collaboration w/ specsavers to raise awareness about hearing loss! 👍

[Video ID: a TikTok video from the user rickastleyofficial showing Rick Astley, an older white man with short brown hair, singing a parody of ‘Never Gonna Give You Up’ in a recording booth. The changed lyrics are:

Then I’m gonna give you up, then I’m gonna let you down / then I’m gonna run around with dessert spoons

Then I’m gonna make you cry, then I’m gonna say goodbye / then I’m gonna tell a lie and hurt you.]