#Journals on Cancer Medicine

[biomedres]

Acral Calcified Angioleiomyoma Along with Radiological Features

Acral Calcified Angioleiomyoma Along with Radiological Features in Biomedical Journal of Scientific & Technical Research

Angioleiomyoma (ALM) is a rare benign, vascular smooth muscle tumor originating from the tunica media of the vessel wall. It typically arises in the cutaneous, subcutaneous tissue of the lower extremities in middle-aged women. The author has previously described the solid subtype of ALM as a painful and vascularized subcutaneous tumor and indicated that all painful cutaneous and subcutaneous tumors used as the acronym “ENGLAND” or “LEND an EGG” show vascularized appearances on high-resolution color Doppler ultrasonography (US). Whereas ALMs of the fingers, toes, hands, and fee as acral type, namely acral calcified ALMs are rarely found. Kacerovska et al. mentioned that the lesion was pathologically composed of mature smooth muscle cells and vascular pattern accompanied with the prominent calcifications. In this article, the current knowledges of the acral calcified ALM have been reviewed in detail. Based on the evidence, acral calcified ALM pathologically shows the changes including calcification, sometimes extensive calcification hyalinization, and bleeding. Similar to the ordinary ALM, it is putative that acral calcified ALM also tends to represent painful and pathologically vascularized tumor. In addition to the characteristic manifestation of painful and vascularized tumor on color Doppler US, an acral calcified ALM should be considered as the differential diagnosis if the mass shows the calcification on high-resolution US in acral regions.

For more articles in Journals on Biomedical Sciences click here bjstr

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[atavist]

An ob-gyn in Virginia performed unnecessary surgeries on patients for decades. He took their reproductive organs, gave them false cancer diagnoses, and did other terrible harm. When his victims learned the truth, they fought back. Issue no. 146, DAMAGES, is now available: 

[Debra] requested her medical records and was stunned to find discrepancies with what Perwaiz had said to her during appointments. Most glaringly, she didn’t see any mention of precancerous cells on her cervix; the tests Perwaiz performed on her had come back normal. “If I was normal,” Debra said, “why did I have a surgery?”

There were other inconsistencies. One form from an appointment described Debra complaining of back and pelvic pain, which she told me she never did. Another document dated the day before her surgery stated that she “insisted on having those ovaries removed through the abdominal wall incision and not vaginally,” and that the “consent obtained after entirely counseling the patient [was] for abdominal hysterectomy.” In fact, she had requested the opposite surgical approach, and she recalled no such conversation with Perwaiz; the only time she’d spoken with him in the lead-up to her procedure was in passing in the hospital hallway.

Debra was sure she had a malpractice case. She went to several lawyers, but none of them would take her on as a client. “So many men—man after man saying, ‘You had a decent amount of care, and that’s all you’re afforded,’ ” she said. Frustrated, she came up with a new plan: “I said, ‘Alright, I’m going to learn how to sue this bastard myself.’ ”

[meggettes]

my mom died a year ago

[crimsonpublishersbiosciences]

Selected Sudanese Medicinal Plants Induce Anticancer and Cytotoxic Effects in Cervical Cancer Cell Line_Crimson Publishers

Abstract:

Modern pharmacology, however, relies on refined chemicals-either obtained from plants, or synthesized. This work investigated the anticancer, antioxidant and Cyto toxicity activities of N. lotus leaves citrate, N. lotus leaves not citrate, P. juliflora leaves commonly used as anti-inflammatory and Ant diabetic. All the plant parts were extracted using 80% methanol, the anticancer activity was examined by using MTT assay against Hela (Cervical Cancer) Cell Line. And determine their antioxidant activities by testing DPPH cytotoxicity using-(4, 5-Dimethyl thiazole-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT), filter and kept in dark, prepared freshly. The examined plants methanolic extracts of P. juliflora leaves is high activity against Hela (Cervical Cancer) Cell Line IC50 is 56.02μg/ml. The extract C N. lotus leaves citrate, N. lotus leaves not citrate has shown none active anti- Hela (Cervical Cancer) IC50 values 100, and >100μg/ml respectively. All the extracts revealed cytotoxicity activity not toxic in N. lotus leaves citrate, N. lotus leaves not citrate, P. juliflora leaves the inhibition percentage with (90.81,89.33074,86.47866) (73.17427,71.93975,60.17069) (74.93001,73.78714, 71.13981) respectively. The following plant parts showed highly potent scavenging activity against DPPH (above 80%); N. lotus leaves citrate, 88.78, While the following revealed a good activity against DPPH (between 60-79); N. lotus leaves not citrate, P. juliflora leaves with inhibition% are 77and 62.96 respectively.

Read More About this Article: https://crimsonpublishers.com/sbb/fulltext/SBB.000537.php

Read More Articles: https://crimsonpublishers.com/sbb/

[truth4ourfreedom]

THE BENEFITS OF IVERMECTIN. IF YOU HAVE CANCER, FREQUENT COLD OR INFECTIONS, MUSCLE SHRINKAGE, CARDIAC ISSUES, CROHNS, HERPES, ETC.

The study was published in the Cureus Journal of Medical Science.  LET'S TALK ABOUT IVERMECTIN 1 – Ivermectin prevents the damage caused to RNA Vaccines.  2 – Ivermectin blocks the entry of Spike Protein into cells.  So, if the person was vaccinated with COVID, they have hope, they have a way to treat themselves through Ivermectin.  3 – Ivermectin is a treatment after Covid and after vaccination, it is an effective medicine in all phases of Covid 19, even before entering the cell, Ivermectin already destroys the virus in the blood.  It only has beneficial effects and no harmful effects in the treatment of the coronavirus.  4 – Ivermectin has a very powerful anti-inflammatory action against Coronavirus.  5 – Ivermectin has a powerful action for traumatic and orthopedic injuries, it strengthens muscles and has no side effects like corticosteroids.  6 – Ivermectin treats autoimmune ailments such as: rheumatoid arthritis, ankylosing spondylitis, fibromyalgia, psoriasis, Crohn's disease, allergic rhinitis.  7 – Ivermectin reduces the frequency of flu and colds.  8 – Ivermectin improves the immunity of cancer patients.  9 – Ivermectin treats Herpes Simplex and Herpes Zoster.  10 – Ivermectin reduces the frequency of sinusitis and diverticulitis.  11 – Ivermectin protects the heart in cardiac overload, in an embolism for example, it prevents cardiac hypoxia because it stimulates the production of basic energy so that the tissue is not destroyed and thus improves cardiac function.  12 – Ivermectin is antiparasitic.  13 – Ivermectin is anti-neoplastic (anti-cancer), it suppresses the proliferation and metastasis of cancer cells, only killing cancer cells and preserving healthy cells, improving the effectiveness of chemotherapy treatment, as it kills cancer cells resistant to chemotherapy, defeating the resistance to multiple chemotherapeutics that tumors develop, and combined with chemotherapy and/or anti-cancer agents, it provides an increase in the effectiveness of these treatments.  14 – Ivermectin is antimicrobial (bacteria and viruses), and increases immunity.  15 – Ivermectin reaches the Central Nervous System and regenerates the nerves.  16 – Ivermectin regulates glucose and insulin metabolism.  17 – Ivermectin regulates cholesterol metabolism.  18 – Ivermectin reduces liver fat in steatose.  19 – Ivermectin protects the liver exposed to insecticides.  20 – Ivermectin attacks the virus wherever it is, regardless of mutations.  21 – Ivermectin serves for the prevention and treatment of coronavirus, surprisingly.  Unproven efficacy is not of Ivermectin, but of vaccines.  22 – Ivermectin, used as a prophylactic agent, was associated with a significant reduction in infection, hospitalization and mortality rates due to COVID-19.  23 - Ivermectin does not attack the liver, since it is not metabolized in it, and if in the intestine, on the contrary, it protects the liver. 

BIG PHARMA DOES NOT WANT YOU TO KNOW THIS.THEY WANT TO SELL YOU THE EXPENSIVE MEDS THEY MAKE BILLIONS ON.

Please read, save and re-blog before Tumblr takes this down.

[cosmicpuzzle]

Which Education🎓📚 is right for you?

Mercury rules your interest and consequently which type of course you would select.

Now you have to see how Mercury is placed. For example if Mercury is conjunct Moon it would have same effect as Mercury in Cancer or Moon opposite Mercury.

Mercury -Sun: It is called Budh Aditya yoga. These people can shine in political science, geology, sociology, medicine and they can be good leaders too. They may prepare for competitive exams.

Mercury-Moon: Some changes or confusion in choice of course. Can study more than one subject but both vastly different from each other. Chemical, hotel management, nutrition, chef, psychology, tarot and intuitive studies.

Mercury-Mars: Some obstacles in education, breaks and interruptions (dropping classes), engineering (especially related to machines, drawings, plans, civil, electronics), medicine (especially related to surgery), fire and safety engineering,

Mercury-Venus: Sales, marketing, HR, interior designing, makeup courses, all type of fine arts, vocational courses, acting courses.

Mercury-Saturn: Engineering (like construction , petroleum, mining core subjects), structural engineering, drafting, administrative studies.

Mercury-Jupiter: Finance, CPA, CMA, accounting, teaching, law field, journalism, VJ, pilots, aeronautical.

Mercury- Rahu: Chemical, nuclear subjects, cinematography, software courses, digital marketing, share markets, computer hardware, import export, AI, Machine Learning courses.

Mercury-Ketu: Computer coding, electrical engineering, bio technology, astrology, virology, research oriented fields.

For Readings DM

[storiesfromgaza]

Hi, everyone.

Yesterday, I shared here a series of posts written by a girl named Nada Bedair on Twitter, where she discussed new information, she learned after watching a documentary.

It was revealed in this documentary that Israel has something called the "Bank of Skins," which is the largest skin bank in the world, specializing in treating burns, skin cancer, and more.

In this documentary, it became clear that most of these skins did not belong to Israeli soldiers but were taken from the bodies of deceased Palestinians, their identities deliberately obscured through disfigurement or lack of proper autopsy.

At the same time, numerous reports emerged from Palestinians, stating that after the arrest of individuals from Gaza and the West Bank, their families were surprised by their return as deceased, with their bodies missing certain body organs!

Simultaneously, an article was published by the head of the Forensic Medicine Institute, claiming that Israel kills and harvests organs from deceased Palestinians without their consent or their families' consent!

Here is the link to the complete post, including the sources: https://www.tumblr.com/storiesfromgaza/732558400585613312/today-i-learned-about-something-terrible-and-i?source=share

It is crucial that you read this before continuing with this article.

After I shared it yesterday, @chimaeraonwards wrote a comment, attaching a link to a Journal Article | Social Research by anthropologist Nancy Scheper-Hughes titled, "The Body of the Terrorist: Blood Libels, Bio-Piracy, and the Spoils of War at the Israeli Forensic Institute." In this article, the author describes in detail what happened and how it happened in around 38 pages.

you can read it here:

Scheper-Hughes, N. (2011). The Body of the Terrorist: Blood Libels, Bio-Piracy, and the Spoils of War at the Israeli Forensic Institute. Social Research, 78(3), 849–886. http://www.jstor.org/stable/23347019

Your reading of it won't take much of your time, but it will significantly increase your awareness of things you might not have imagined happening!

If reading it is a challenge, it's worth to mention that yesterday, @chimaeraonwards did an amazing thing. She wrote a breakdown of some of the content of the 38-page article. Ensure you read it; it's not very long, but it's highly enlightening. Link: https://www.tumblr.com/chimaeraonwards/732568635164524544/whatever-youre-thinking-about-this-its-actually?source=share Support her by sharing it because she truly deserves it.

[thehappybroadcast]

Over seven million women suffer from breast cancer, making it one of the deadliest cancers across the globe.

A team of researchers at the University of Washington School of Medicine (UWSM) has been working on a breast cancer vaccine for over the last 20 years. In their recently published study, they finally revealed the results of the phase one human trials of their breast cancer vaccine.

The study is published in the journal JAMA Oncology. During the phase one trials, the experimental breast cancer vaccine has proved to be safe and highly effective in preventing the growth of human epidermal growth receptor 2 (HER2) cancer tumor cells. High levels of HER2 protein in the body are responsible for causing the most complex, aggressive, and rapidly spreading type of breast cancer in women. Therefore, the new vaccine might turn out to be a groundbreaking discovery in the field of modern medicine.

The researchers are now conducting phase two trials of their vaccine. If successful, it’d be one of the greatest miracles of medical science – fingers crossed! Source: Interesting Engineering (link in bio) #science #cancer #innovation https://www.instagram.com/p/CnCQgiVO_xi/?igshid=NGJjMDIxMWI=

[mindblowingscience]

Ancient Egyptians may have tried to treat cancer with surgery more than 4,000 years ago, a study has revealed. The findings were published in May in the journal Frontiers in Medicine and add to a growing body of work seeking to expand our understanding of how one of the world’s most important civilisations tried to tackle diseases, especially one as deadly as cancer.

Continue Reading.

[biomedres]

SARS-CoV-2 and its Transmission Ability Through the Nasal and Oral Cavities

SARS-CoV-2 and its Transmission Ability Through the Nasal and Oral Cavities in Biomedical Journal of Scientific & Technical Research 

https://biomedres.us/fulltexts/BJSTR.MS.ID.006075.php

Since the beginning of the pandemic caused by the SARS-CoV-2 virus, it was identified that its ligand Spike Protein (S protein) is the receptor of the Angiotensin-Converting Enzyme 2 (ACE2), which is present in epithelial cells of the nasal mucosa, the surface of the tongue in the oral cavity, the pharynx, and the salivary glands [1]. These last have a higher ACE2 expression, which facilitates the virus to infect a person. Because saliva is a secretion from the oral cavity produced by the parotid, sublingual, and submandibular glands, it is in constant contact with perioral tissue, such as the tongue, which due to its mobility, facilitates saliva to be in contact with the entire oral cavity [2]. The presence of viral RNA in saliva has allowed the detection of the SARS-CoV-2 virus in the early stages of infection and promptly identify asymptomatic individuals [2,3]. Saliva also contains IgA and IgG isotype antibodies which could be relevant in immunized people against SARS-CoV-2 [2]. In general, if a healthy person comes into contact with aerosols contaminated with the virus, the following alternatives can occur: a) If the virus enters through the open oral cavity, it will come into contact with saliva. The viral particles could go into the digestive tract because the epiglottis blocks saliva access to the lungs [4], thus reinforcing findings of the virus in feces [5] and gastrointestinal symptoms.

For more articles in Journals on Biomedical Sciences click here bjstr

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[astroismypassion]

✨PART OF FORTUNE IN SIGNS AND HOUSES SERIES: 6TH HOUSE✨

Credit goes to astrology blog @astroismypassion

ARIES PART OF FORTUNE IN THE 6TH HOUSE

You feel the most abundant when you have Aries and Virgo Sun people in your life. You could make money via fitness training, personal training, firefighting, law enforcement, emergency healthcare services, competitive sports, trading, stockbroking, automotive repair, mechanics, tech startups. You feel abundant when you come up with new, fresh ideas.

TAURUS PART OF FORTUNE IN THE 6TH HOUSE

You feel the most abundant when you have Taurus and Virgo Sun people in your life. You could make money via offering a service connected with pet sitting, tutoring or helping people to organise their kitchen, fridge, storage. You may also clean offices or make work environment more beautiful (for example putting on pictures, cleaning the computer). You feel the most abundant when you are stable on a daily basis and know what to expect from your daily schedule and when your work ethic, work relations are stable and grounded.

GEMINI PART OF FORTUNE IN THE 6TH HOUSE

You feel the most abundant when you have Gemini and Virgo Sun people in your life. You could make money via freelance journalism, you can write for newspapers, magazines, online publications. You can have abundance via starting a podcast or YouTube channel. You may offer translation, interpretation or language teaching services if you are multilingual. You feel abundant when you organise a networking event or a conference even. You could also blog about your profession or teach people about what is it that your job entails.

CANCER PART OF FORTUNE IN THE 6TH HOUSE

You feel the most abundant when you have Cancer and Virgo Sun people in your life. You could make money via blogging about topics related to home, family and well-being. You may start a blog or write for publications that focus on these areas. You would be an excellent planner! Planning and organising family-oriented events, such as weddings, birthday parties or even community gatherings in your local town. You could also offer pet sitting, dog walking or even start a pet grooming service.

LEO PART OF FORTUNE IN THE 6TH HOUSE

You feel the most abundant when you have Leo and Virgo Sun people in your life. You could make money via voice acting or doing voice-over work for commercials, animations or audiobooks. You will find fulfilment, joy, success and wealth in activities that promote mental and physical wellness. You might make organic make up or creams. You feel the most abundant when you incorporate hobbies, interests and passion into your daily life. You could also be a health advocate.

VIRGO PART OF FORTUNE IN THE 6TH HOUSE

You feel the most abundant when you have Virgo Sun people in your life. You could make money via starting your own online store selling products related to your interests connected to books, tech gadgets or dietetics/nutrition. You can set up a shop on Shopify or Etsy. You experience wealth by providing consulting services in your area of expertise. You may be a travel blogger or write travel articles, but more so on a local level, maybe also connected with short-distance travel.

LIBRA PART OF FORTUNE IN THE 6TH HOUSE

You feel the most abundant when you have Libra and Virgo Sun people in your life. You could make money via providing recipes for lunches for working people, like easy DIY ideas. You may also create meal plans for school children. You can create wealth by selling prints, stock photos or offering photography services.

SCORPIO PART OF FORTUNE IN THE 6TH HOUSE

You feel the most abundant when you have Scorpio and Virgo Sun people in your life. You could make money via working in alternative medicine or wellness, becoming a financial advisor or running your own cleaning business or provide services for neighbours or in your local town. You can offer cleaning or yard work services to neighbours or in your local community.

SAGITTARIUS PART OF FORTUNE IN THE 6TH HOUSE

You feel the most abundant when you have Sagittarius and Virgo Sun people in your life. You could make money via working in non-profits, via wellness coaching, physical therapy, working in educational institutions, hospitality industry, tour guiding, working for airlines, travel blogging, working in media, especially related to educational content, travel, running a small business that involves sharing knowledge or providing specialized services.

CAPRICORN PART OF FORTUNE IN THE 6TH HOUSE

You feel the most abundant when you have Capricorn and Virgo Sun people in your life. You could make money via farming, gardening, manual labor and agriculture, management, administration, working with your hands, project management, quality control and research. You definitely need to ask for a promotion.

AQUARIUS PART OF FORTUNE IN THE 6TH HOUSE

You feel the most abundant when you have Aquarius and Virgo Sun people in your life. You could make money via information technology, software development, working with cutting-edge technologies, via astronomy or astrology, via social enterprise, digital marketing, advocacy work, activism and community organizing, via renewable energy, sustainable development or green technologies.

PISCES PART OF FORTUNE IN THE 6TH HOUSE

You feel the most abundant when you have Pisces and Virgo Sun people in your life. You make money via tarot, healing, holistic medicine, work with elderly people or at a hotel. You could find success in making jewellery, specializing in anklets. You feel acquire wealth through counselling, psychotherapy, psychology, nursing, holistic therapies (like reiki or acupuncture), teaching meditation, drama/music therapy or dance/movement therapy, caregiving, hospice work, starting a creative arts studio, a holistic wellness center or socially conscious business.

Credit goes to astrology blog @astroismypassion

[bullshit-tqia]

A list of side effects and risks for mtf estrogen:

This is thanks to a friend, she gets full credit for this post.

"Some takeaways: almost none of the studies report that estrogen does anything positive to male bodies, except lowering blood pressure in young people and stopping balding

Essentially most of the articles were freaking out about how we need more high quality data to determine if estrogen is safe or not, but of the studies I went through:"

Risks associated with estrogen use by men found:

Heart Risks: Venous Thromboembolism (VTE): 9 articles

Myocardial Infarction (MI): 5 articles

Ischemic Stroke: 5 articles

Other Cardiovascular Events: 6 articles

Fertility Risks: 6 articles

Cancer Risks: 8 articles

Key Dangers that evidence found in MTF people:

Dangers to the Heart:

Venous Thromboembolism (VTE): Increased risk reported across multiple studies.

Myocardial Infarction (MI): Elevated risk associated with estrogen therapy.

Ischemic Stroke: Increased incidence observed in studies.

Other Cardiovascular Events: General cardiovascular disease risks

Dangers to Fertility: Impacts on spermatogenesis and testicular health, with some studies noting fertility preservation in a portion of trans women.

Dangers to Cancer Risk: Potential increased risk for breast cancer and other hormone-sensitive malignancies. Dangers that are suspected based on know qualities of estrogen:

Cancer Risks: Potential increased risk for specific cancers beyond breast cancer, such as papillary thyroid cancer and other hormone-sensitive malignancies.

Liver Toxicity: Concerns regarding hepatotoxic effects and liver integrity due to long-term estrogen use.

Cardiac Arrhythmias: Suggested increase in the rates of cardiac arrhythmias in some studies, although direct causation remains unclear.

Gallbladder Issues: Potential association with gallstones and pancreatitis, but more research is needed for conclusive evidence.

Long-term Bone Health: Uncertainty about how long-term estrogen use affects bone density and overall bone health.

Psychiatric Effects: Speculation about possible mood changes or psychiatric effects, though this is often individualized and not well documented.

Metabolic Changes: Concerns about changes in metabolism and body composition, including the risk of obesity, but conclusive links remain to be established.

On regaining fertility after estrogen:

After an average of three years on estrogen, ony 40% of trans women will still be fertile. After discontinuation of hormones, 66% will get their fertility back (with the span of the study), and most of the people observed had impaired semen quality after stopping. The contributing factor may be the age when hormones were started, with older people being more protected.

But hey, I'm just an alarmist.

Sources:

https://www.sciencedirect.com/science/article/abs/pii/S0090429519306302 https://www.cell.com/cell-medicine/fulltext/S2666-3791(22)00422-0 [1:12 PM] Bock, M. E., et al. "Incidence of Venous Thromboembolism in Transgender Women Prescribed Estrogen." Clinical Chemistry, vol. 65, no. 1, 2019, pp. 57-66. https://academic.oup.com/clinchem/article/65/1/57/5607952.

Keshavarz, M., et al. "Spermatogenesis in Transgender Women." Journal of Clinical Endocrinology & Metabolism, 2020. https://www.sciencedirect.com/science/article/abs/pii/S0090429519306302.

Bhasin, S., et al. "Estrogens and Tumorigenesis." Prostate, vol. 79, no. 9, 2019, pp. 1027-1033. https://onlinelibrary.wiley.com/doi/abs/10.1002/pros.23322.

Kearney, T., et al. "Prostate Cancer in Transgender Women." JAMA Network Open, vol. 2, no. 7, 2019. https://jamanetwork.com/journals/jama/article-abstract/2820386.

Kley, M. A., et al. "Estrogen and Testicular Health." BMC Urology, vol. 18, 2018, p. 68. https://link.springer.com/article/10.1186/s13256-018-1894-6.

Chen, C. L., et al. "Cardiovascular Risks in Transgender Patients." American Journal of Physiology-Heart and Circulatory Physiology, vol. 324, no. 4, 2023, pp. H674-H688. https://journals.physiology.org/doi/full/10.1152/ajpheart.00299.2022.

Lee, D. L., et al. "Hematologic Complications of Estrogen Therapy." Annals of Internal Medicine, vol. 167, no. 1, 2017, pp. 46-55. https://www.acpjournals.org/doi/full/10.7326/M17-2785.

Van Kesteren, P. J., et al. "Long-term Cardiovascular Risks of Hormone Therapy." Circulation Reports, vol. 5, no. 4, 2023. https://www.jstage.jst.go.jp/article/circrep/5/4/5_CR-23-0021/_article/-char/ja/.

Naderi, H., et al. "Risks of Cardiovascular Disease in Transgender Women." The Journal of Clinical Endocrinology & Metabolism, vol. 104, no. 8, 2019, pp. 3505-3514. https://www.sciencedirect.com/science/article/abs/pii/S0890623820301295.

Mehta, A., et al. "Estrogen and the Liver." American Journal of Gastroenterology, vol. 115, no. 1, 2020, pp. 15-23. https://journals.lww.com/ajg/fulltext/2020/10001/S2417_The_Skinny_on_Estrogen_and_Liver_Fat.2417.aspx.

Miller, L. J., et al. "Venous Thromboembolism in Transgender Women." American Journal of Health Promotion, vol. 78, no. 18, 2022, pp. 1674-1680. https://academic.oup.com/ajhp/article-abstract/78/18/1674/6264946. Smith, C. R., et al. "Bone Density in Transgender Patients." Journal of Bone and Mineral Research, vol. 37, no. 4, 2022, pp. 643-650. https://academic.oup.com/jbmr/article/37/4/643/7516770.

Tam, D. Y., et al. "Implications of Estrogen on Cancer Risk." Frontiers in Endocrinology, vol. 12, 2021. https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2021.718200/full.

Gupta, A., et al. "Estrogen Therapy and Pancreatitis." The American Journal of Cardiology, vol. 125, no. 12, 2020, pp. 1836-1842. https://www.sciencedirect.com/science/article/abs/pii/S0890623820301295.

Johnson, J. E., et al. "Long-term Effects of Estrogen on Metabolism." Cell Medicine, vol. 9, no. 4, 2022. https://www.cell.com/cell-medicine/fulltext/S2666-3791(22)00422-0.

[nullarysources]

Evidence of surgical tumor removal in ancient Egyptian skull is 'milestone in the history of medicine'

Mindy Weisberger for CNN:

Cancer is often regarded as a disease of the modern age. However, medical texts from ancient Egypt indicate that healers of the time were aware of the condition. Now, new evidence from a skull more than 4,000 years old has revealed that ancient Egyptian physicians may have tried to treat certain cancers with surgery.

The skull belonged to a man who was about 30 to 35 years old when he died, and it resides in the Duckworth Laboratory collection at the University of Cambridge in the United Kingdom. Since the mid-19th century, scientists have studied the skull's scarred surface, including multiple lesions thought to represent bone damage from malignant tumors. Archaeologists regard the skull, labeled 236 in the collection, as one of the oldest examples of malignancy in the ancient world, dating back to between 2686 BC and 2345 BC.

But when researchers recently peered more closely at the tumor scars with a digital microscope and micro-computed tomography (CT) scans, they detected signs of cut marks around the tumors, suggesting that sharp metal instruments had been used to remove the growths. The scientists reported the findings Wednesday in the journal Frontiers in Medicine.

…

However, it's unknown whether the healers tried to remove the tumors while the patient was still alive, or if the tumors were removed after death, for analysis, Camarós told CNN.

Even ancient Egyptians agree: fuck a cancer

[marzipanandminutiae]

Let’s talk about arsenic, bay-bee

Let’s talk about how, in 1893, doctors working for the Boston Journal of Health chemically analyzed samples of “Dr. Campbell‘s safe arsenic complexion wafers,“ one of the most prolific brands thereof sold in the United States as complexion aids, and found that the product contained either no arsenic at all or amounts so tiny they were barely detectable (varied from wafer to wafer), and that indeed the wafers were mostly made of “milk sugar” AKA lactose

Proving once and for all, I guess, that the safest way to consume arsenic is to take out the arsenic

(also, yes, a lot of people back then did think that eating arsenic sounded as ridiculous as it does today. The only reason the trend enjoyed any success at all is that I’m guessing people were aware that certain toxic compounds can be used to produce medicine, just like today)

(I also found a Dr. Campbell’s ad with a fake testimonial claiming that his wafers could cure cancer. Where the hell am I)

[msbarrybeeson]

Before You Go | Future Donnie & April Insight (Part VI)

(Reader Included)

A/N: Any constructive criticism is appreciated. Reader comments and feedback are also welcomed a lot. 

I have been gone for a long time. Just occupied with my studies! No fan fiction author curse or anything (yet).

Summary: You’re both adopting-parents of Casey. The story follows the perspective of Donatello and April O’Neil during the Kraang apocalypse. You and Leonardo decided to ask them to watch over thirteen-year-old Casey.

In other words, familial interactions between April, Donnie, and Casey Jr.

Reader: Gender-neutral pronouns are used, except the terms “(Mom / Dad)” are also used. Second POV.

Pairing: Rise! Future! Leonardo X Reader

Warnings: Bittersweet.

Word Count:  ~3490

Parts: One / Two / Three / Four / Five / Six / ...

~

Donnie knew how much of a genius he was.

It was no surprise after all. In his late teens, he improved NASA’s satellites to communicate with planets light centuries away. He cured breast cancer through the use of protons in radiation therapy to target specific cells, rather than affecting the harmless. Hell, he even managed to discover a new type of radioactive particles: mutons. By that point, he—.

“—should have been given a Nobel Prize in Medicine and in Chemistry.” Donnie cursed under his breath. He strolled over to his lab bench, equipping his goggles.

Squeeeak. 

April– who was found seated on Donnie’s roughed-up, spinning gaming chair– raised an eyebrow. Her hair had grown out and was left unbounded. Faint wrinkles and eye bags on her features displayed maturity, in contrast to a couple of years ago. However, everyone was well aware that time was not the only factor. 

“Whatcha going on about now, Donnie?”

The softshell huffed. “Recall when I wrote a report about my experimental findings with an invention meant to revive a deceased human being?”

“...You mean the one where you thought it was a good idea to open up Curie’s tomb? Even gone as far as to ask for my help?” April grimaced. “Who’d ever forget that.”

She proceeded to massage her temples. 

“God. You were in all kinds of messed up for that, Don.”

Lightning-like yellow sparks flickered as Donnie had his robotic hands occupied with a butane torch. His goggles were sealed tight around his eyes as he built a oval-looking device on his lab bench. Titanium outer-layer over a seriously complex circuit-board; appearing as if Samsung marketed grenades.

He scoffed. “Oh please. It wasn’t as if I’d taken long to understand how Marie Curie deserves her rest for her great contributions to radiation. Thus is why–.”

“–You decided to take a poor random husband of an old wife,” April interjected.

“Ahem.” Donnie pronounced. “The poor woman was begging me for her husband to be alive again. I was simply gracious and generous enough to not charge her for the process.” He set aside the butane torch. “At least it progressed well; he stayed alive for an additional two years. It gave his wife psychological comfort, and I was able to submit my paper to the N.S.F..” 

He picked up a screwdriver. “Except....” 

April could tell her friend’s eye was twitching. 

“They rejected my findings, nearly had me detained, and claimed it was far too ‘unethical.’” Donnie raised his volume. “Scoff! As if those researchers weren’t committing the crime themselves! Taking bodies away from families and claiming them as scientific property without permission.

If I could go back in time and shove my documents in their jaws, you bet I would.”

April smirked. “Well, I have my regrets too, Donnie.”

“You sound rather amused, April. Is that so surprising? And here I never thought you would regret your part-time job at Albearto’s. Or the fact you wasted money to switch to journalism in university.”

WHACK!

April threw her bat at Donnie’s head, flying back to her hand like a boomerang.

“Watch your mouth, mister. I may have regretted Albearto’s, but not a single moment in my life did I ever regret my journalism passion.” She stood up.

“Ouch.” The softshell vocalized, squinting his eyes toward her. His robotic clampers paused, setting aside the torch and taking off his goggles. 

“Mind yourself, April. Horse-playing is forbidden in the laboratory. I am not consenting to having yet another silver-titanium apparatus get scratched because of you.” Donnie gritted his teeth. “Can you hear the negative connotation?”

“Seriously, Donnie? Where’d that come from? Not only was that years ago but it ain’t anything except a simple accident.” 

“‘Simple accident?’” the softshell repeated with dramatic offense. “An accident, like many others in science labs, which could have caused severe damage! Remember the incident when your teacher dumped bleach and vinegar into the trash bin?

You know, if you had paid any attention in your chemistry class, those two would make mustard gas?” Donnie side-eyed his friend. “Simple accidents can have serious consequences, O’Neil.”

A hand crept up the lab bench.

“Uh-huh, and I’m supposed to believe an instance of me knocking over your phone and books would kill somebody?” April crossed her arms. “If anything, the blame’s yours for not organizing your desk when you got drunk on coffee.”

The hand took ahold of the butane torch.

“Donatello? Disorganized? Sounds cheap coming from you, a student majoring in Journalism.”

April pulled up her coat’s sleeves. “Oh boy, you’re about to get it—.”

Squeeeak!

Heads spun and found a 13-year old boy, replacing April’s spot on Donnie’s chair. Casey eyed the torch with a great yet concerning amount of curiosity.

“Yo, what’s this for, Uncle Don?”

At lightning speed, while April ran to move the gaming chair away further from the workbench, Donnie snatched the tool from his hands. “Child. Casey. Young man.” The softshell heaved loudly. “I must inform you this is NOT meant to be handled with such casual ease. How in Hawking did you even—.”

“Don’t your lab have a passcode or something?” 

“–Is what I am wondering myself, O’Neil. I refuse to believe this child remembers the beginning thirty numbers of π–.”

“Nope, only us.” April and Donnie lifted their gazes to his lab entrance. You leaned on the frame while a dear red-eared slider stood just behind. A couple of steps inside, and the metallic lab door shut close. 

Donnie– strangely– was quick to hide his device-in-progress off to the side.

“You’re back!” April grinned. “Hell, you would not believe the convo Donnie and I were having a minute ago.” She hurried to hug you.

“Figures,” Leo remarked. “We could practically hear you yards off.”

“Sounds like things never get old.” You smiled.

There was a side-eye between Donnie and April, before the Commander proceeded to inquire, coughing: “Anyhow.. care to explain the occasion? You two don’t seem to be in a hurry.”

“The only times you ever visit my laboratory are to prepare for immediate combat engagement, and you look awfully collected.” The softshell furrowed his brows.

“No, no.” You waved your hands, shaking your head. “Thank God no. We came here to ask if you two could take care of our Casey here while we head out.” The other turtle scrunched his in-quote eyebrows. “You— You came here to request us to... babysit him?”

April jabbed him in his plastron.

“You see? Just like I said.” Leo turned to you. “I know my brother, love. Don’s not the kind of guy to take responsibility for a kid. Or anyone, really.”

“Hold on.” Donnie narrowed his eyes. “I never said I refused, Leo.”

“Don’t know, it sounds like it to me.”

“Well, my misinformed brother, contrary to your belief, I am perfectly capable of handling a child.”

You huffed with amusement. Your husband only winked back.

“If you say so, Don.”

“Where are you two heading off for if you needed us to watch over him?” April inquired. “Wondering, ‘cause this never happened even when you two leave for patrol.”

“Just finding some time for ourselves.”

April exclaimed, “As in a honeymoon? Why not just say so? We’ll leave you two alone–.”

“–In this economy and climate?” Donnie interjected. “Has it also not been six years since your yet-to-be-legal marriage?”

“Alright, alright,” Leonardo chuckled. “Cut us some slack, bro. Finding time wasn’t easy when there’s Kraang above our necks.”

“Right, and you’re going on a honeymoon, how?” The softshell crossed his arms. “Simply because you’re the leader does not equate to you making wise decisions, Leo.”

“His ōdachi can teleport anyone to anyplace, we have some hope we can easily teleport to a remote area,” you answered. “One without Kraang infestation. It’ll be hard, but we may as well try.”

“Bonus points if we find clear skies and an ocean.” The red-eared turtle grinned, wrapping his arm over your shoulders.

“What’s a honeymoon, (Mom / Dad)?”

Your hand went to caress Casey’s cheek. “Parent quality time. It just means you get to handle yourself like the responsible grown-up you’ll become one day. Just promise me you’ll be on your best behavior around Uncle Don and Auntie April?”

“I promise, (Mom / Dad)!”

“Good boy,” Leo laughed, ruffling the kid’s hair.

“You didn’t ask Mikey and Raph to help out too, or?”

“Between you and me, I think you guys are better of making sure Casey doesn’t get into any chaos,” you whispered to April. “Don’t tell them that, though.”

She laughed. “Okay, I see how it is. You both have fun.” 

Donnie bit his lip. Right as Leonardo and (Name) turn to exit the laboratory, he extended his arm out to them.

“Leo, (Name).”

You two faced back to him once more.

“Don’t kill yourselves out there.”

Everyone’s eyes widened– April, you, and Leonardo himself. But the brother in blue snickered, holding a smile that reached his eyes. “So you do also care for me, Don. And all this time I thought you were plotting to put me in my grave or something.”

“We won’t.” Leo placed a hand on your shoulder. “You got my word.”

“Bye (Mom / Dad)! Bye Papa!”

“We’ll be back soon, Casey!”

Donnie stood in silence as you finally left, leaving himself with none other than his best friend and his nephew. “I refuse to believe this is the future we have to deal with.”

“Times changed all of us, didn’t they?” April spoke. “One day we wish each other a good one, and the next, we hope we just don’t die. I could’ve been a famous news anchor by now, make my mother happy, fight crime without worrying about dying the next second.

..I wonder if there’s anyone else out there besides the small number of us down here.”

“..I doubt it.”

Donnie pulled himself together and walked back to his workbench, operating his clampers to work once again. He put on his goggles. Casey, being a young teenager of enthusiasm, peeked over.

“Watch yourself, boy,” April warned.

“Don’t worry about me, Auntie. I’m only standing over here.” Casey narrowed his eyes upon the glowing and metal-like ball his uncle had his tools on. “What are you working on, Uncle Don?”

“A sphere.”

“A sphere?”

“You heard correctly.”

“That sounds kind of boring.”

Donnie had to hold himself back from remarking with: ‘That is exactly what every child whose intellect is doomed would say.’

“I’m sure your mother would find it rather moving.”

“(Mom / Dad)? I don’t understand what’s emotional about a ball, though.”

“Hey Casey.” April coughed. “Why not tell us about your mask here? Haven’t taken a good look at it before. Maybe Uncle Don would like to hear it too.”

“You actually want me to talk about my mask?”

“Ain’t a problem, is it?”

“No.” He fidgeted with his fingers a bit. “You don’t have anything else to do?”

“We were just told to watch over you, kid.”

“Yeah, but everyone I know is always busy with the Kraang or supplying weapons. I never really get chances to hang out.”

There was a brief pause in the butane torch’s flame.

April’s expression softened. Her hand came up to brush his black hair. “Things have gotten calmer up there. So you’ve got plenty of time with us now.”

Casey smiled.

“So your mask?” 

The boy alternated between covering his face and removing it. “(Mom / Dad) gave it to me. She told me it is based on the one worn by my biological mother. (Mom / Dad) also said that my birth mother was kind of crazy-funny and likes to be loud. She would have a stick to play– what was it– hockey?

I don’t know what kind of game hockey is supposed to be, but I guess it’s nice to know how life was like before all the Kraang.”

A sad smile crept on April’s lips. 

“Anyways, I thought the mask looked kind of plain, so I decided to draw red marks on it. See?” Casey showed his mask off, fingers tapping the surface. “Guess who it looks like!”

There were two bold and thick streaks of red. Each one ran through one eye, truly a defining characteristic. The Commander chuckled, already imagining how much pride her friend in blue would feel from the fact a kid– let alone one he had been parenting– looked up to him so much.

“You know, I am seeing someone familiar here.” April hummed as she put on a thoughtful facade. Fingers holding her chin and everything. “Got to be Uncle Don.”

Named turtle paused for a moment and raised a brow.

“Seriously, Auntie April?” On the other hand, Casey gave her an incredulous look and shook his head. “You probably want to get your eyes checked out, ‘cause Uncle Don doesn’t have any red stripes.” Off to the side. “And even if he did, he won’t look as cool as Dad.”

April snickered behind her palm as Donnie eyed the boy from behind his goggles.

“You’re right, you’re right. Just messing with you, kid.” Her hand ruffled his hair once more. “Sounds like you really admire your Papa, don’t you?”

“Why wouldn’t I? Dad has an awesome sword that opens up portals. He always moves so quickly whenever he’s fighting. Bam! And the Kraang’s gone!” The teenager stretched his arm for emphasis. “Even as the leader, Papa knows when to get serious and when to make people laugh. He also cares a lot about me, (Mom / Dad), you guys, and everyone!”

It made even Donnie himself smile. 

However, the way Casey’s enthusiasm died down had not gone unnoticed. “I’ve always wanted to help out though.” He sighed, shoulders slumping. “I want to fight the Kraang right by his and (Mom / Dad)’s side. Except I barely get the chance to, because they keep telling me to stay close to base and hide behind a giant rock.”

April crossed her arms and went quiet. His feelings were nothing new. In fact, she experienced the same thing herself, seeing she had always been a human. It was like that until–.

“Have no hard feelings,” Donnie spoke up, his hands and eyes remained on his spheric gadget. The sparks were flying. “Your parents are merely worried about your well-being.”

“I know, I know. They won’t have to though, if I can have enough training or something.” Casey sighed. “Then again, I also know I’m only a normal sensitive human.

...Why can’t I be a mutant instead?”

“Ahem. You are classified as a human. That is a true statement and one you cannot change.” Donnie hummed. “However, that does not mean you cannot be strong and capable in other ways.”

“Why does it sound like you’ve been in my place before?”

“Perhaps I did. Did you truly think being a soft-shell turtle is easy? I happened to be born as one of the only Testudines species whose outer shell cannot protect.” Donnie remarked. “Casey, your mask.” His hand signaled.

“What about my mask?”

“I merely want to add something.”

Confused, he hopped off the chair and handed the mask over. “Hmm. As long as you don’t mess with the stripes, Uncle Don.”

“Who says I won’t?”

Casey kicked Donnie’s leg.

“‘Ow,’ I say sarcastically without feeling physical pain.”

“Hmph.” He crossed his arms. “Why do you keep saying things like that?”

“Such as?”

“You say those action verbs, even when you’re already doing them.”

April snorted. “Just his thing, kid. Uncle Don’s got his special quirks.”

“Do you have a quirk?”

“Picking unnecessary fights for one,” Donnie commented.

“You only call them ‘unnecessary,’ because you never want to fix the problem.”

He rolled his eyes. “My solution would’ve been ten times more efficient if you had allowed my technology and I to do the work.”

Casey wondered. “Does your tech ever go haywire, Uncle Don?”

“No.”

“Oh man,” April began, “you should’ve been there for this one time. Your Uncle Don was building some kind of overprotective bed to keep your late Gramps from waking up from his beauty sleep.”

“Gramps likes to sleep?”

“You’d be surprised to hear that he sure does.”

“Then what happened?”

“Uncle Don asked your Dad, Uncle Mikey, and Uncle Raph to try punching, slicing, throwing whatever they could on the bed. They were attacking it like crazy!”

“And then?” 

“And the bed was even more insane, ‘cause there were actual missiles shooting out! They went straight for his brothers. At some point, it got overboard, so Uncle Don tried to command it to stop.”

“I’m hearing a ‘but’ coming.”

“But it malfunctioned and thought Uncle Don was the enemy!”

“However!” Donnie pointed his finger up, interrupting the story-telling. “It did not take long for my creation to recognize his master.”

“Still went haywire in my book,” April remarked. 

“Ignoring that.” His robotic hand tapped the edge of his workbench, grabbing Casey’s attention. “Come here, young man.” He slid back the mask, except in his hands, it felt as if the frame had thicken.

“It looks the same, but it doesn’t feel the same?”

“Try wearing it over your face.”

The boy did as told. All of a sudden, a bunch of green rectangles and words appeared in his vision. He gasped in awe. He spun around slowly, watching the rectangle focus on a figure through the wall.

“Yes yes, I know. I am well aware of how amazing I am.” Donnie huffed in pride. “I have opted to construct an interface with your mask. I cannot see why you shouldn’t have something to defend yourself with,” he reasoned. “I have other updates in mind later on. As of now, however, your mask will help you detect life forms across other rooms or through other objects.” 

“That’s so cool!” The boy hesitated though. “But I don’t want to break it or anything.”

“Hey.” April rested her hand on Casey’s shoulder, giving a firm squeeze. “Our resources are already scarce. Using then losing them is better than nothing. You better make the most of our tech. Understood, soldier?”

Casey grinned underneath his mask. He fixed his posture up and saluted. “Gotcha–! Understood, Commander!” 

He faced the inventor, whose hands were already back to being occupied with the “sphere.” “Thanks so much, Uncle Don!” Casey exclaimed, leaping towards the turtle to give a tight hug. “You’re the best!” 

Upon contact, Donnie stiffened up, but his lack of experience with physical touch did not prevent a smile forming on his face. He extended a robotic arm, patting Casey’s back. 

The boy then scanned around curiously with his mask. “Hey! Think I spot Uncle Mikey and Uncle Raph two floors down! They’re holding hands over a table or something. Why are so many people circling around them?”

April rolled her eyes. “Sounds like another arm-wrestling match between the our youngest and oldest brother.” 

Just like that, Casey booked it out of the laboratory so quickly, it reminded her of a certain red-eared slider. “What the–! Casey!” April groaned. “And here I thought we don’t have to deal with runaway kids. I better catch up to him.” 

“Would not worry about him too much,” Donnie commented. 

“What do you mean by that?”

“Considering we will not always be alive to protect him... the sooner we leave him to himself, the easier it will be for him to survive alone.” 

“Hey. Come on now.” April walked to her best friend’s side. “Don’t you say things like that. We’re all going to survive this together–.”

“April.” Slight pain wavered in his voice. “You know as well as I do how our current reality is. It is only a matter of time before the Kraang finds everyone.” 

“Yet you’re still here trying.”

No response.

“It’s all because of the kid, isn’t it?” April affirmed. “He ain’t any genius prodigy you were expecting long ago. But he gave you a reason to try– he became someone worth fighting for.”

“I would not put it as simply as that.”

She shrugged. “That’s how I’d say it. You know you’re not the only one whose life changed because of Casey.”

Donnie paused his work, turning off the butane torch and finally pulling his goggles off his eyes again. “...Casey reminds me of when we were young, being rash and immature teenagers like any other. I hate admitting to such thing, but I was one too. And I hate admitting much more how much I missed those times.

The child has known nothing of the trouble we’ve experienced outside, April: when Cassandra was killed, when Draxum was torn apart, when Dad decided to sacrifice himself despite the slim odds.” His hands clenched into fists.

“Do not expect me to have any false hope for our future, but do not assume I would want Casey to feel the same way. For as long as he can, I want him to hold onto that false hope.”

“...” April had her arms crossed. Her eyes slowly came to linger on the workbench. “Is that ‘sphere’ his false hope?”

“..No. Not his.” Donnie traced his thumb over his contraption. “It’s for (Name).”

[reasonsforhope]

"One in five Americans will experience major depressive disorder in their lifetime, and many will not find relief from current therapies. But now researchers have identified an unexpected source of the problem: inflammation.

Inflammation in the body may be triggering or exacerbating depression in the brains of some patients. And clinical trial data suggests that targeting and treating the inflammation may be a way to provide more-precise care.

The findings have the potential to revolutionize medical care for depression, an often intractable illness that doesn't always respond to conventional drug treatments. While current drug treatments target certain neurotransmitters, the new research suggests that in some patients, depressive behaviors may be fueled by the inflammatory process.

It appears that inflammatory agents in the blood can break down the barrier between the body and the brain [and specifically the blood-brain barrier], causing neuroinflammation and altering key neural circuits, researchers say. In people at risk for depression, inflammation may be a trigger for the disorder.

Research suggests that only a subset of depressed patients - roughly 30 percent - have elevated inflammation, which is also associated with poor responses to antidepressants. This inflammatory subgroup may be a key to parsing out differences in underlying mechanisms for depression and personalizing treatment...

The inflamed body and the depressed brain

...A number of studies show that depressed patients tend to have increased inflammation compared with non-depressed subjects, including more inflammatory cytokines and C-reactive protein — which is produced by the liver in response to inflammation — circulating in the blood. Patients with autoimmune diseases have inordinately high rates of depression. And postmortem brain samples from people who died by suicide showed more activation of the brain’s immune cells, which release inflammatory agents.

Crucially, pro-inflammatory drugs can induce people to become depressed, which suggests a causative link. In one seminal study published in the New England Journal of Medicine, Miller and his colleagues conducted a double-blind study of 40 cancer patients undergoing treatment with interferon-alpha, an inflammatory cytokine.

Though none of the patients had depression to begin with, the inflammatory agent had a striking effect: Many became depressed, a finding that has been consistently replicated.

"The patients recognize pretty much immediately that, 'Hey, you gave me something, and now I feel this way. I don't know why I feel this way,'" Miller said.

Can treating inflammation treat depression?

If inflammation can induce or exacerbate depression and its symptoms, then reducing inflammation could provide relief.

Even if inflammation is a disease modifier rather than the cause of the problem, “you have to take care of it in order for you to be able to get your therapeutics working to restore your circuitry and what’s happening in the mind,” said Eleonore Beurel, a professor of psychiatry and behavioral sciences at the University of Miami Miller School of Medicine.

Anti-inflammatory drugs, used alone or in conjunction with a standard antidepressant, may help some depressed patients. A 2019 meta-analysis encompassing almost 10,000 patients from 36 randomized clinical trials found that different anti-inflammatory agents, including NSAIDs, cytokine inhibitors and statins, could improve depressive symptoms...

“We’ve come to the tipping point,” Miller said. “And we know enough at this point to begin to target the immune system and its downstream effects on the brain to treat depression. We are there.”

How to manage your own inflammation

Experts agreed that people should not take anti-inflammatories without talking with their health-care provider. Your doctor can order a C-reactive protein blood test to measure your level of inflammation.

“There are so many patients who do not respond to antidepressants,” said Ole Köhler-Forsberg, a physician and associate professor of psychiatry at Aarhus University who has given anti-inflammatory drugs to his patients in addition to antidepressants. “So there is the issue of how can we improve the individual outcomes.” Tailoring treatment for each individual on a holistic basis may add some benefit.

More clinical tests for inflammatory markers may be a way to differentiate the effectiveness of antidepressant treatment. If confirmed, it would “be the first actual biomarker in psychiatry,” Raison said. “I mean, we’ve been looking for biomarkers for 50 years and had zero luck. And it’s ironic that it’s not a brain chemical.”

In the meantime, “you get much more mileage out of the lifestyle changes than you would out of supplements or any other over-the-counter drugs at this point,” Miller said."

-via The Washington Post (via Yahoo News), February 24, 2023