#Ioad

[ethnicdreams]

Today was spent working from home and in McDonald's. 😊 ❤️ Here' some cosy and cute pictures from today. ☀

[mrboggins1103]

So, to add along with Dr with his title, Brian will now be SIR Dr. Brian Harold May CBE

All I can say is, IT'S ABOUT TIME

Edit: Sorry, lovies! To clarify, do I now realize that I have mistakenly written down the wrong title for Brian? Yes. The topic has been touched, but all I simply wanted to do was congratulate Brian on his new title. (which again I realize I wrote down incorrectly)

Brian's now title is, Sir Brian Harold May, CBE

All my love to Brian and Anita!

~end scene~

[antiqua-lugar]

Lae'zel: I will carry your hope, Prince Orpheus, and I will carry your burden. But to that burden I must add my own - the loss of those I leave behind.

lae'zel you are everything to me i love you so much

[crttvset]

bootsy keeps trying to get in my face and trying to step on my ioad when im drawinf no girl!!!!! like nooooo omfg

[gidd-blog1]

Customs hands over 6,240 seized dynamites to DSS

The Kebbi Area Command of the Nigeria Customs Service has seized about 6,240 pieces of cap-sensitive dynamite explosives along the Yauri-Jega ioad. Area Comptroller of Customs, Iheanacho Ojike, said the dynamites were intercepted by the joint border patrol team of Customs, Army, police, Immigration and the Department of State Services while on intelligence-based patrol along the Yauri-Rega…

[falling-on-a-bruise]

Today Is…International Overdose Awareness Day

International Overdose Awareness Day (IOAD) is the world’s largest annual campaign to end overdose, remember without stigma those who have died from overdose, and acknowledge the grief of the family and friends left behind.I assume the overdoses implied are drugs but the saying is that you can never get too much of a good thing but try saying that to someone who has just eaten 1,800 cups of rice…

[lasclscale]

Eboot resigner 4.75

#EBOOT RESIGNER 4.75 INSTALL#

#EBOOT RESIGNER 4.75 UPDATE#

#EBOOT RESIGNER 4.75 DOWNLOAD#

RazorX has updated his CFW Eboot/PKG resigner app. Tea here is tommydanger's graphical user interface for making PSX Eboots. Then use the resigner for the EBOOT file. Extract LIMBO.pkg to the psn2isodiscstructure folder in the folder. Extract it and place your Eboot in the same folder and run the exe. Change the EBOOT.BIN file with the ODE resigner. So 4 me it looks like setting APPVER of disc-PARAM.SFO APPVER of update-PARAM.SFO isnt way to go.īecause of thát i incréased APPVER óf disc-PARAM.SF0 and now gamé simply falls báck to xmb.How to Convert PSN PKG Games to Folder Backup Game CFW PS3.

#EBOOT RESIGNER 4.75 UPDATE#

When i fix the installed update with PSN Patch game starts and plays fine. Ive done exactIy what ive déscribed in post87 but get blackscreen on game-start, which is normal behaviour if u start a game that need fw system-fw. PS3-System: 4.46-Cobra-CFW Update has 1 EBOOT.BIN and 1 self-file. It searches recursivIy through the diréctory for pkgs, unpácks one, searches 4 spu-self, deletes unpacked pkg, continues to next pkg and so on. You simply havé to póint it to á directory containing updaté-pkgs. Oh, I didnt know that about stage2.bin, thanks. That sounds Iike too much troubIe to hunt fór spu.self. Rudi RasteIli, I guess somé games put thé spu binaries insidé the elf ór in sdat. Other than thát, the end óf the 2 elfs should match. The last 0x30 bytes of npdrm ebootsprxself is npdrm only disc game files dont have this. Thanks for finding it and also for reporting the right information that showed me exactly the problem to fix. I forgot tó subtract the deIeted header padding sizé from the séction header offset. I guess spu-selfs are much harder to find.Įdit: Bug Why after resigning (resigntodisc) last part of elf is always different than original Update 1.01 Wolfenstein.

#EBOOT RESIGNER 4.75 INSTALL#

The updates fór Portal 2 have lot of.sprx files.īut keep in mind Portal 2 does not work on Cobra-systems if u dont install the new patched stage2.bin from deank.

#EBOOT RESIGNER 4.75 DOWNLOAD#

edit: deIeted this vérsion with bug fóund by jo3tómas, download version 0.1.4 below. Like i said couple posts earlier, you need resign SDATs only if you want to play on CFW 3.55.Ĭlick to expand. I think théy extract the eIf from the éboot, Ioad it in ida, ánd find the paraméter that is passéd to np typé calls like scenpdrmisavaiIable. to find klic usually people send me a klic with the file or I look in aldos list of klics, I also used his bruteforce program a couple times, and I made a very simple bruteforcer that only finds keys in plain text. Sure i can patch your tools to use.ps3 instead. One of thése tools i actuaIly use to tést a kIicensee is testklic.éxe which éxpects ps3kéys in.ps3 which leads tó the unnessessary situatión thát i must have bóth folders with exactIy the same contént. Change APPVER and VERSION of PARAM.SFO(game-folder) to the values found in update n 9.Ĭhange PS3SYSTEMVER of PARAM.SFO(game-folder) to 3.55 You think this is the way to go Im still not sure what to do with these.sdat-files.īigJokker over at maxconsole uses a program called makenpdata in his batch-script to resign them, but im still not sure if this is a nessessary step or not And i wanna know: What do you do to obtain the Klicensee Another thing i run across with your tools: U use ps3keys as name for the folder containing the ps3keys, while most other tools i know use.ps3 for this.

[mmorgblitz]

Can you move i doser doses between computers

Youll see this: Noticed the Purchased string and the YES under it thats where the app checks if youve bought the doses or not.Īll you have to do is search for a NO under a Purchased string and turn it into a YES easy. This next stép is the Iast one tó trick the ápp into thinking yóu have bought thé app. You should havé noticed that yóu already have aIl the doses ás.mp3 audio fiIes. Now scroll dówn a Iittle bit and yóu should find á file called áist. Now find I-Doser Now go inside the I-Doser folder youve found, and in to the iDoser.app folder. This will onIy make it éasier for you tó find the ápps folder Then gó ahead and navigaté to varmobileApplications lt should take somé seconds to Ioad the Applications foIder, depending on thé number of ápps installed, ás it is chécking the names óf the apps themseIves for you tó be able tó find them easiIy. I recommend buying as the app is really worth it OK Lets start First open iFile and go to the settings. Separate findings will be published soon, and the team is planning further testing of a combination therapy in HNSCC with SHP2 and EGFR inhibitors.One you can do directly on your iPhoneiPod and one for Windows, but what you are going to do is exactly the same thing. In addition to neuroblastoma, Faber's team also found SHP099 to be effective in head and neck squamous cell carcinoma (HNSCC). Currently, Faber's group is also planning to test SHP2 inhibitors in combination with anti-GD2 therapy, an approved immunotherapy for neuroblastoma. "These findings suggest that, unlike MEK inhibitors, SHP2 inhibitors may be dosed high enough to inhibit MEK/ERK signaling in neuroblastoma tumors," said Faber, who credited the high efficiency and capabilities of the Cancer Mouse Models Core at Massey for allowing his team to comprehensively test SHP099.Īs there are a large number of SHP2 inhibitors now in clinical testing, Faber will work with collaborator John Glod, M.D., Ph.D., to hopefully bring one of these inhibitors into clinical testing at the National Cancer Institute. "We found variable yet consistently positive effects across all models of low NF1, high-risk neuroblastoma, revealing a new drug target in relapsed disease," said Faber, who is also an associate professor in the Philips Institute for Oral Health Research at the VCU School of Dentistry.įaber said one of the most important findings in the study - made by first authors Jinyang Cai, Ph.D., and Sheeba Jacob, Ph.D., - was that SHP2 inhibitors were ineffective at blocking the function of MEK/ERK in healthy cells and therefore were not toxic to them. Additionally, they determined that NF1 expression is much lower in advanced or relapsed neuroblastoma cells, and the protein is more readily deactivated in high-risk neuroblastoma. SHP099 had a particularly effective impact in tumor cells that had limited or no expression of the neurofibromin 1 (NF1) protein. Repeatedly, Faber and his research team found that neuroblastoma tumors in mice were sensitive to SHP099, and the tumors shrank considerably in some of the models. High-throughput screening is an important method in drug discovery and design that allows researchers to automate thousands to millions of tests on chemical or biological compounds. This compound belongs to a new class of drugs that target and block an enzyme called SHP2, which is along the same genetic pathway as MEK/ERK. To address the lack of effective treatment options for neuroblastoma, Faber's laboratory along with his collaborators performed high-throughput drug screening with SHP099. Endowed Chair in Cancer Research at VCU Massey Cancer Center. "Breakthroughs significantly altering the fate of high-risk neuroblastomas have been elusive," said study author Anthony Faber, Ph.D., co-leader of the Developmental Therapeutics research program and Natalie N. However, a class of drugs used to prohibit the function of these proteins called MEK inhibitors have proven ineffective in treating the disease because high doses are associated with a substantial level of toxicity. Previous research has demonstrated that the activation of a specific group of proteins - MEK/ERK - helps neuroblastoma cells survive and grow. Despite multiple medical advancements that have improved outcomes for the disease, high-risk neuroblastoma remains responsible for the most cancer-related deaths in children five years and younger. Neuroblastoma is a type of cancer that develops in nerve tissue, most commonly in the glands around the kidneys.

[aurora-daily]

Full live @ Terminal 5 in New York yesterday!

Setlist: 

00:00:47 - Infections of a Different Kind 

00:07:13 - The River 

00:12:01 -  A Different Kind of Human 

00:16:08 - All is Soft Inside 

00:21:22 - Warrior 

00:25:13 - Cure for Me 

00:28:49 - Apple Tree 

00:34:28 - Exist for Love 

00:39:26 - Murder Song (5, 4, 3, 2, 1) 

00:45:36 - Runaway 

00:49:58 - The Seed 

00:54:38 - Queendom 

01:01:31 - Running with the Wolves 

01:07:45 - Giving in to the Love 

01:13:01 - Daydreamer (Encore)

[introspection-of-a-deserter]

Introspection of a Deserter: chapter 4, page 14 They fucked up a bit. I wanted to wait for 1k followers before doing this but you know what? Life is short and I’m not sure I’ll reach the number so hear ye, hear ye! An Introspection of a Deserter discord server is hot and ready to be lanched. Invite yourself by clicking on this link!  New Readers Read it on Tapas

[essereilsole]

Universitari a me: stavo pensando di organizzarmi per prendere un ipad da poter sfruttare per usarlo per l’uni, ho l’impressione che sia molto più comodo rispetto ad un pc, però non so.. ditemi voi. Qualcuno che ce l’ha e effettivamente lo usa?

[harmreduction]

Ending the overdose crisis will take all of us. We may not see a year with no overdoses in our lifetimes, but reducing harm and healing from the multi-generational harms of the drug war will require collective action. In the last few years, we’ve seen harm reduction as a movement grow. There is more awareness and support for naloxone. And yet, so many barriers remain to getting overdose prevention resources to the people who need them. We need universal access to naloxone and harm reduction services, on demand access to evidence-based treatment, and everything in our toolkit that we know works. But that won’t be enough if we don’t also stand together to fight against racialized drug policies, heal from stigma and shame, and challenge the systemic harms faced by people who use drugs and their families. It will take all of us.

Read more: https://harmreduction.org/blog/ending-the-overdose-crisis-will-take-all-of-us/ 

[readingrecap]

International Overdose Awareness Day 2022 Video

International Overdose Awareness Day 2022 Video

Town Manager Fidel Matez, Police Chief David Clark, Coalition Director Erica McNamara, School Superintendent Dr. Tom Milaschewski and the Coalition Advisory Board invited the community to join the Reading Police Department, the Reading Coalition for Prevention & Support and the Mystic Valley Public Health Coalition as they recognized International Overdose Awareness Day down at the Town Common on…

[nychealth]

It’s International Overdose Awareness Day

More New Yorkers die from drug overdoses than from homicides, suicides and car crashes combined. These deaths are preventable. 

The medication naloxone can reverse the effects of an opioid overdose. All New Yorkers can receive free training to carry and use naloxone. 

Together we can end overdose!

Additional resources

Alcohol and drug use main page

Prevent overdose

Opioid addiction treatment with buprenorphine and methadone

Overdose prevention resources for providers

[connoisseurofk9s]

#OverdoseAwareness #OverdoseAwarenessDay #IOAD #InternationalOverdoseAwarenessDay (at Marion, Indiana) https://www.instagram.com/p/CTO-WwbLZm2/?utm_medium=tumblr

[danyainstitute]

We grieve and remember those lost. We work to #endoverdose.