#Hirotaka Takahashi

[putschki1969]

Sword Art Online FULL DIVE 10th Anniversary Event

Yuki Kajiura and her team participated in the 10th Anniversary event “Sword Art Online -Full Dive-”, which was held at Tokyo Garden Theater on November 6th. A rip is already on Bilibili! The YK section starts at around 1:23:00

Keiko Tweet | SAO Tweet | Keiko Instagram

Setlist overture~swordland moon and shadow Aerial fight MC luminous sword a sword of bravery in her heart she has to overcome her fear -- longing -- 蒼穹のファンファーレ : I really like that we got everyone on stage for this brand new song. Feels like a proper celebration. The studio version is not my favourite because I am not a fan of Aoi Eir, ASCA or ReoNa but this live version is pretty neat.

[Date and time] November 6, 2022 [Venue] Tokyo Garden Theater [Participating Cast &Artists] Cast: Yoshitsugu Matsuoka, Haruka Tomatsu, Miyuki Sawashiro, Rina Hidaka, Kanae Ito, Aoi Yuki, Ai Kayano, Nobunaga Shimazaki, Hiroaki Hirata, Hiroki Yasumoto, Inori Minase Artists: Eir Aoi, ASCA, ReoNa, Luna Haruna, Yuki Kajiura, Surprise Guest: LiSA

Participating Members: Yuki Kajiura (Piano) Vocals: Remi, KAORI, KEIKO, YURIKO KAIDA, Joelle MUSICIAN: FRONT BAND MEMBERS Koichi Korenaga (Guitar), Kyoichi Sato (Drums), Tomoharu “Jr.” Takahashi (Bass), Rie Akagi (Flute), Hirotaka Sakurada (Keyboard), Yoshio Ohira (Manipulator) -Hitoshi Konno Strings- Hitoshi Konno (Violin), Tomomi Tokunaga (Violin), Naomi Urushibara (Violin), Shiori Watanabe (Violin), Tomohiro Kobayashi (Viola), Takayoshi Okuizumi (Cello)

■ Official Website: https://sao-p.net/

Live Streaming Option for Overseas Fans

Streaming Platform: Stagecrowd Ticket price: 4,500 yen Purchase period: October 29 ~ November 13 Archive period: ~ November 13

[goalhofer]

2024 olympics Japan roster

Archery

Nakanishi Junya (Okayama)

Saito Fumiya (Gifu Ichi)

Furukawa Takaharu (Aomari Ichi)

Noda Satsuki (Kitakyushu)

Athletics

Higashida Akihiro (Nara)

Ota Tomoki (Hamamatsu)

Kasai Jun (Aichi)

Ogawa Daiki (Shizuoka)

Koyama Naoki (Saitama Ichi)

Hamanishi Ryo (Osaka)

Koga Yuta (Fukuoka)

Yamamoto Shouma (Osaka)

Nishi Yudai (Tokyo)

Yoshizu Takuho (Tokyo)

Takahashi Kazuki (Iwate)

Abdul Sani-Brown (Sakado)

Sakai Ryūichirō (Toyonaka)

Uzawa Towa (Miyagi)

Iizuka Shōta (Omaezaki)

Ueyama Koki (Matsusaka)

Satō Fūga (Tokyo)

Satō Kentarō (Tokorazawa)

Nakajika Yuki (Tokyo)

Izumiya Shunsuke (Yokohama)

Rachid Muratake (Matsuda)

Takayama Shun'ya (Hiroshima)

Tsutsue Kaito (Kumamoto)

Toyoda Ken (Tokyo)

Miura Ryūji (Hamada)

Aoki Ryōma (Kuki)

Akasaki Akira (Ōzu)

Ōsako Suguru (Machida)

Ikeda Kōki (Hamamatsu)

Kiryū Yoshihide (Hikone)

Yanagita Hiroki (Tokyo)

Kawabata Kaitō (Matsusaka)

Kawano Masatora (Hyūga)

Akamatsu Ryōichi (Gifu Ichi)

Shinno Tomohiro (Hiroshima)

Hashioka Yūki (Saitama)

Roderick Dean (Kobe)

Goshima Rino (Kanazawa)

Kokai Haruka (Myoko)

Morimoto Mariko (Osaka)

Tanaka Nozomi (Ono)

Goto Yume (Kakogawa)

Yamamoto Yuma (Nagoya)

Kabasawa Wakana (Maebashi)

Takashima Yuka (Hōfu)

Fukube Mako (Hiroshima)

Tanaka Yumi (Osaka)

Ichiyama Mao (Izumi)

Suzuki Yuka (Daisen)

Fujii Nanako (Nakagawa)

Okada Kumiko (Ageo)

Yanai Ayane (Fukuoka)

Hata Sumire (Yao)

Kitaguchi Haruka (Asahikawa)

Saitō Marina (Mito)

Ueda Momone (Itoshima)

Badminton

Kōdai Naraoka (Aomori Ichi)

Nishimoto Kenta (Ise)

Hoki Takurō (Yamaguchi Ichi)

Kobayashi Yūgo (Sendai)

Watanabe Yūta (Suginami)

Yamaguchi Akane (Katsuyama)

Ōhori Aya (Aizuwakamatsu)

Matsuyama Nami (Kitakyushu)

Shida Chiharu (Hachirōgata)

Matsumoto Mayu (Sapporo)

Nagahara Wakana (Akita Ichi)

Higashino Arisa (Iwamizawa)

Basketball

Yoshii Hirotaka (Osaka)

Togashi Yūki (Shibita)

Tajon Jacobs (Los Angeles, California)

Kawamura Yuki (Yanai)

Hiejima Makoto (Fukuoka)

Kai Toews (Kobe)

Hachimura Rui (Sendai)

Watanabe Yūta (Miki)

Yūdai Baba (Toyama Ichi)

Josh Hawkinson (Shoreline, Washington)

Keisei Tominaga (Tokyo)

Hugh Hogland-Watanabe (Honolulu, Hawaii)

Stephanie Mawuli (Nagoya)

Evelyn Mawuli (Nagoya)

Takada Maki (Toyohashi)

Yoshida Asami (Tokyo)

Machida Rui (Asahikawa)

Motohashi Nako (Asaka)

Yamamoto Mai (Hiroshima)

Hayashi Saki (Itoshima)

Miyazaki Saori (Saitama)

Miyazaki Yuki (Yokohama)

Todo Nanaka (Sapporo)

Akaho Himawari (Kanazawa)

Boxing

Harada Shudai (Tokyo)

Sewon Mensah-Okazawa (Kanoya)

Breakdancing

Ono Hiroto (Tokyo)

Nakarai Shigeyuki (Sapporo)

Yuasa Ami (Kawaguchi)

Fukushima Ayumi (Kyoto)

Canoeing

Tanaka Yuuki (Tokyo)

Haneda Takuya (Toyota)

Okazaki Haruka (Tokyo)

Yazawa Aki (Iida)

Climbing

Narasaki Tomoa (Utsunomiya)

Anraku Sorato (Yachiyo)

Mori Ai (Mito)

Nonaka Mihō (Tokyo)

Cycling

Arashiro Yukiya (Ishigaki)

Ōta Kaiya (Okayama)

Obara Yuta (Hashikami)

Nakano Shinji (Hanamaki)

Nagasako Yoshitaku (Kasaoka)

Imamura Shunsuke (Ukiha)

Hashimoto Eiya (Gifu Ichi)

Kuboki Kazushige (Furudono)

Nakamura Rimu (Kyoto)

Kawaguchi Urara (Hyogo)

Yonamine Eri (Osaka)

Sato Mina (Chigasaki)

Ōhta Riyu (Ageo)

Kakita Maho (Kitakyushu)

Ikeda Mizuki (Ōnojō)

Uchino Tsuyaka (Fukuoka)

Kajihara Yūmi (Saitama Ichi)

Hatakeyama Sae (Yokohama)

Diving

Shō Sakai (Sagamihara)

Tamai Rikuto (Takarazuka)

Mikami Sayaka (Yonaga)

Enomoto Haruka (Utsunomiya)

Arai Matsuri (Itami)

Equestrian

Kawai Mike (Valkenswaard, The Netherlands)

Ōiwa Yoshiaki (Münsingen, Germany)

Tomoto Kazuma (Motosu)

Kitajima Ryūzō (Kobe)

Tanaka Toshiyuki (Fukuoka)

Shibayama Haase-Takashi (Kobe)

Satō Eiken (Ogawa)

Sugitani Taizō (Izumi)

Fencing

Kanō Kōki (Ama)

Minobe Kazuyasu (Echizen)

Yamada Masaru (Toba)

Iimura Kazuki (Kyoto)

Matsuyama Kyōsuke (Tokyo)

Shikine Takahiro (Ōita Ichi)

Nagano Yūdai (Ibaraki)

Yoshida Kento (Morioka)

Yoshimura Miho (Tokyo)

Azuma Sera (Wakayama Ichi)

Miyawaki Karin (Tokyo)

Ueno Yūka (Hita)

Emura Misaki (Ōita Ichi)

Fukushima Shihomi (Munakata)

Takashima Risa (Ōmuta)

Ozaki Seri (Sapporo)

Field hockey

Nakamura Eika (Tochigi)

Asai Yū (Hiroshima)

Suzuki Miyu (Gifu Ichi)

Nagai Yuri (Kakamigahara)

Nagai Hazuki (Kakamigahara)

Oikawa Shihori (Tokyo)

Kozuka Miki (Nikko)

Kobayakawa Shiho (Matsue)

Mori Kanon (Hiroshima)

Toriyama Mai (Tokyo)

Tanaka Saki (Morika)

Urata Kana (Osaka)

Shimada Amiru (Ōtsu)

Omoto Sakurako (Iwakuni)

Hasegawa Miyu (Matsue)

Ogawa Rika (Gifu Ichi)

Golf

Matsuyama Hideki (Sendai)

Nakajima Keita (Saitama Ichi)

Yamashita Miyū (Neyagawa)

Sasō Yūka (San Ildefonso, The Philippines)

Gymnastics

Hashimoto Daiki (Chiba Ichi)

Kazuma Kaya (Funabashi)

Oka Shinnosuke (Kamakura Ichi)

Sugino Takaaki (Kamakura Ichi)

Tanigawa Wataru (Funabashi)

Nishioka Ryusei (Higashiosaka)

Kishi Rina (Toda)

Nakamura Haruka (Osaka)

Okamura Mana (Yokkaichi)

Ushioku Kohane (Nagoya)

Mori Hikaru (Tokyo)

Handball

Nakamura Takumi (Fukuoka Ichi)

Yasuhira Kosuke (Takaoka)

Sakurai Tomoya (Mito)

Okomoto Daisuke (Yamaguchi)

Fujisaka Naoki (Fukui)

Takano Sota (Tokyo)

Sugioka Naoki (Kariya)

Yoshida Shūichi (Wakayama Ichi)

Adam Baig (Fukuoka Ichi)

Tokuda Shinnosuke (Iwakuni)

Watanabe Jin (Ōita)

Motoki Shida (Mito)

Tamakawa Hiroyasu (Tokyo)

Yoshino Tatsuki (Misato)

Judo

Nagayama Ryuju (Bibai)

Abe Hifumi (Kobe)

Hashimoto Soichi (Tokyo)

Nagase Takanori (Mito)

Murao Sanshirō (Tokyo)

Aaron Wolf (Tokyo)

Saito Tatsuru (Osaka)

Tsunoda Natsumi (Yachiyo)

Abe Uta (Kobe)

Funakobu Haruka (Fujiyoshida)

Tashiro Takaichi (Tokyo)

Niizoe Saki (Kashihara)

Takayama Rika (Tokyo)

Sone Akira (Kurume)

Pentathlon

Satō Taishū (Aomori Ichi)

Uchida Misaki (Kumagaya)

Rowing

Furutu Naoki (Tottori)

Miyaura Masayuki (Mito)

Arakawa Ryūta (Yokohama)

Hirouchi Emi (Kyoto)

Ōishi Ayama (Nagoya)

Rugby

Ishida Taiga (Kumamoto)

Ishida Kippei (Amagasaki)

Tsuoka Shotaro (Fukuoka Ichi)

Matsumoto Junya (Kagoshima)

Josua Kerevi (Viseisei, Fiji)

Fukushi Moeki (Hyogo)

Taninaka Kippei (Hyogo)

Noguchi Yoshihiro (Tokyo)

Ueda Kazuma (Hyogo)

Maruo Takamasa (Tokyo)

Okudaira Yu (Hyogo)

Koga Yoshiyuki (Tokyo)

Yoshizawa Taichi (Tokyo)

Utsumi Hanako (Yokohama)

Ōtani Mei (Kyoto)

Kajiki Marin (Fukuoka Ichi)

Saegusa Chiaki (Sapporo)

Tanaka Emii (Uozu Ichi)

Tsutsumi Honoka (Ureshino)

Nakamura Chiharu (Yokohama)

Nishi Arisa (Tokyo)

Hara Wakaba (Niigata Ichi)

Hirano Yume (Tokyo)

Matsuda Rinka (Fuchu)

Mizutani Sakura (Mie)

Sailing

Tomizawa Makoto (Kashiwazaki)

Okada Keiju (Kitakyushu)

Iitsuka Shibuki (Yokohama)

Tanaka Misaki (Higashiura)

Nagamatsu Sera (Ōita Ichi)

Oura Nishida-Capiglia (Mie)

Yoshioka Miho (Fujisawa)

Shooting

Okada Naoya (Tsuyama)

Yoshioka Dai (Kyoto)

Nobata Misaki (Ōita Ichi)

Skateboarding

Nagahara Yuro (Hakuba)

Onodero Gin'u (Yokohama)

Shirai Sora (Sagamihara)

Horigome Yūto (Tokyo)

Hiraki Kokona (Tomakomai)

Yosozumi Sakura (Iwade)

Kusaki Hinano (Tsukuba)

Yoshizawa Koko (Sagamihara)

Akama Rizu (Sendai)

Nakayama Fūna (Toyama Ichi)

Soccer

Leo Kokuba (Chiba Ichi)

Suzuki Kaito (Shizuoka Ichi)

Nishio Ryūya (Osaka)

Sekine Hiroki (Shizuoka Ichi)

Kimura Seiji (Chiba Ichi)

Kawasaki Sota (Kōfu)

Yamamoto Rihito (Yokohama)

Joel Chima-Fujita (Tokyo)

Fujio Shota (Osaka)

Saitō Kōki (Tokyo)

Hosoya Mao (Ushiku)

Nozawa Taishi (Naha)

Araki Ryotaro (Kumamoto Ichi)

Mito Shunsuke (Yamaguchi Ichi)

Takai Kota (Yokohama)

Ōhata Ayumu (Fukuoka Ichi)

Hirakawa Yu (Kashima)

Keiji Sato (Tokyo)

Uenaka Asahi (Fukuoka Ichi)

Yamada Fuki (Minakuchi)

Uchino Takashi (Chiba Ichi)

Yamashita Ayaka (Tokyo)

Hirao Chika (Matsudo)

Shimizu Risa (Kobe)

Minami Moeka (Yoshikawa)

Kumagai Saki (Sapporo)

Takahashi Hana (Kawaguchi)

Tōko Koga (Osaka)

Kitagawa Hikaru (Kanazawa)

Hasegawa Yui (Sendai)

Miyazawa Hinata (Minamiashigara)

Seike Kiko (Tokyo)

Nagano Fūka (Tokyo)

Momoko Tanikawa (Nagoya)

Fujino Aoba (Machida)

Hayashi Honoka (Uji)

Ueki Riko (Kawasaki)

Tanaka Mina (Kawasaki)

Hamano Maika (Takaishi)

Shū Ohba (Fujisawa)

Moriya Miyabi (Nara Ichi)

Ishikawa Rion (Akita Ichi)

Chiba Remina (Tsukuba)

Surfing

Inaba Reo (Ichinomiya)

Connor O'Leary (Cronulla, Australia)

Kanoa Igrashi (Huntington Beach, California)

Matsuda Shino (Yokohama)

Swimming

Matsuyama Riku (Saitama Ichi)

Takehara Hidekazu (Munekata)

Taniguchi Taku (Hyogo)

Terakado Genki (Mito)

Murasa Tatsuya (Nagoya)

Mano Hidenari (Yokohama)

Matsumoto Riku (Tokyo)

Minamide Taishin (Kainan)

Matsumoto Katsuhiro (Iwaki)

Watanabe Ippei (Tsukumi)

Hanaguruma Yu (Sakaide)

Mizunuma Naoki (Moka)

Honda Tomoru (Yokohama)

Seto Daiya (Moroyama)

Matsushita Tomoyuki (Utsonomiya)

Kanagimoto Kōnosuke (Imari)

Higa Moe (Hiroshima)

Kobayashi Uta (Nagano)

Shimada Ayano (Mie)

Wada Ami (Nagano)

Yasunaga Mashiro (Tochigi)

Sato Tomoka (Tsukuba)

Kijima Moeka (Hakusan)

Yoshida Megumu (Nagoya)

Ebina Airi (Sapporo)

Matsumoto Shiho (Shizuoka Ichi)

Hirai Mizuki (Kariya)

Ikee Rikako (Tokyo)

Suzuki Satomi (Onga)

Aoki Reona (Tokyo)

Tanigawa Ageha (Osaka)

Narita Mio (Tokyo)

Kobori Waka (Nara Ichi)

Mitsui Airi (Yokohama)

Makino Hiroko (Tokyo)

Ōhashi Yui (Hikone)

Igarashi Chihiro (Yokohama)

Shirai Rio (Takarazuka)

Ikemoto Nagisa (Nara Ichi)

Masuda Aoi (Kurashiki)

Table tennis

Shinozuka Hiroto (Nagoya)

Harimoto Tomokazu (Sendai)

Togami Shunsuke (Tsu)

Hayata Hina (Kitakyushu)

Hirano Miu (Numazu)

Harimoto Miwa (Sendai)

Tennis

Nishikori Kei (Bradenton, Florida)

Taro Daniel (Bradenton, Florida)

Naomi Osaka (Los Angeles, California)

Uchijima Moyuka (Kuala Lumpur, Malaysia)

Aoyama Shūko (Osaka)

Ena Shibahara (Rancho Palos Verdes, California)

Triathlon

Kenji Nener (Perth, Australia)

Odakura Makoto (Tokyo)

Takahashi Yūko (Mitaka)

Volleyball

Nishida Yūji (Inabe)

Ōnodera Taishi (Natori Ichi)

Fukatsu Akihiro (Hiroshima)

Miyaura Kento (Kumamoto Ichi)

Ōtsuka Tatsunori (Osaka)

Yamauchi Akihiro (Aichi Ichi)

Sekita Masahiro (Tokyo)

Takahashi Kentarō (Yamagata)

Takahashi Ran (Kyoto)

Yūki Ishikawa (Okazaki)

Kai Masato (Tokyo)

Yamamoto Tomohiro (Ebetsu)

Uchida Akiko (Tokyo)

Ishii Miki (Fujisawa)

Kojima Manami (Sendai)

Fukudome Satomi (Tokyo)

Araki Ayaka (Tokyo)

Wada Yukiko (Tokyo)

Tominaga Koyomi (Komae)

Hayashi Kotona (Osaka)

Sarina Koga (Saga Ichi)

Mayu Ishikawa (Okazaki)

Nanami Seki (Funabashi)

Inoue Arisa (Maizuru)

Nichika Yamada (Nagoya)

Miyabe Airi (Kobe)

Water polo

Watanabe Taiyo (Kyoto)

Ogihara Daichi (Kagoshima)

Kai Inoue (Los Angeles, California)

Date Kiyomu (Osaka)

Nitta Ikkei (Kanazawa)

Nishimura Towa (Kyoto)

Tanamura Katsuyuki (Ishigaki)

Adachi Seiya (Kakamigahara)

Suzuki Toi (Yamagata)

Takata Mitsuru (Hiroshima)

Inaba Yūsuke (Toyama)

Ōkawa Keigo (Tsuchiura)

Araki Kenta (Fukuoka Ichi)

Weightlifting

Miyamoto Masanori (Naha)

Murakami Eishiro (Toyama Ichi)

Suzuki Rira (Shiroi)

Wrestling

Sogabe Kyotaro (Matsuyama)

Higuchi Rei (Ibaraki Ichi)

Kiyooka Kotaro (Kōchi Ichi)

Takatani Daichi (Kyōtango)

Ishiguru Hayato (Tokyo)

Fumita Ken'ichirō (Kōfu)

Kusaka Nao (Takamatsu)

Susaki Yui (Matsudo)

Fujinami Akari (Yokkaichi)

Sakurai Tsugumi (Kōchi Ichi)

Motoki Sakura (Saitama Ichi)

Ozaki Nonoka (Tokyo)

Kagami Yuka (Yamagata Ichi)

[nanchan83]

ZOZO

Fashion Tech News Concept Movie

Cast : Fumina

Director : Shinnosuke Fukushima (UW)

Assistant Director : Kengo Oshikawa (UW)

Director of Photography : Yu Sato

1st Assistant Camera : Yuko Tamura

2nd Assistant Camera : Ryo Takahashi

DIT : Takahiro Shimokawa

Drone Pilot : Takafumi Todo (UW)

Edit : Shinnosuke Fukushima (UW)

Colorlist : Haruka Egawa (Artone Film)

Lighting Director : Nagisa Miyazono

Chief Lighting Assistant : Rei Horiuchi

Lighting Assistant : Takuro lto / Mitsumasa Okamoto /Ryota Niya

Production Designer : Naomi lwase (R.mond)

Assistant Production Designer : Hirotaka Sakurada

Stylist : Mayako Shigeta

Hair & Make up : Miyuki Namba

Sound Recording : Takuya Kubo

Composer : Kazuki lnoue

Location Coordinator : Hironori Togawa

Casting : Tatsuya Mochizuki (Casting Voice)

Production Assistant : Yui Takeuchi (UW) / Kai Kato

Production Manager : Saki Yamada (Lieetz)

Producer : Yuki Sagahara (Basedon)

Production : UW Inc. / Basedon Inc.

[myjhersey17]

ELLEGARDEN「THE BOYS ARE BACK IN TOWN TOUR 2018」千葉・ZOZOマリンスタジアム公演の様子。（Photo by Tsukasa Miyoshi [Showcase]）

[aramajapan]

ELLEGARDEN to return from hiatus after a decade-long absence

Nearly 10 years after going on an indefinite hiatus, punk rockers ELLEGARDEN have announced that they will be making their return to the music scene.  This announcement came suddenly yesterday evening, the news blowing up across both Twitter and Japanese media sites. While no new music has been confirmed, the band will be embarking on […]

Read more on aramajapan.com

[mistress-of-the-obvious]

FictionJunction Music Member News

Some fairly new and old news that some people may not know.

Yuki Kajiura is slated to work on a new Madokoa Magica anime entitled Magia Record: Puella Magi Madoka Magica Gaiden. She has recently completed 18 new songs. Whether it’s for Madoka Magica or some other project is unknown. She is continuing to work on additional songs with the Front Band Members. The Composers Summit Concert featuring some of the greatest video game and anime related composers will happen on December 28. Yuki Kajiura, the Front Band Members, Konno’s strings, along with Kaori Oda, Joelle, and Yuri Kasahara will perform. She is releasing a new single with Aimer for the anime Fate Stay Night Heaven’s Feel Part II Lost Butterfly. The song title is “I Beg You.” It’s scheduled to be released on January 9th. The Flying Dog anniversary event will happen on February 2nd featuring FictionJunction Yuuka. On the February 3rd, 17th, and 23rd are new FictionJunction Station Fan Talk Events. On April 24th Sword Art Online Alicization OST will be release with the second OST being released on July 24th. She will be featured in this month’s Lisani! volume 35 and has done two online interviews you can find here: https://www.famitsu.com/news/201811/16167737.html https://www.gamer.ne.jp/news/201811160073/

Kaori Oda has announced on Twitter she is currently in the studio working on a new album. She has also announced a small acoustic tour around March of next year, which will be Tokyo, Nagoya, and Osaka. In May she intends to go on another tour. In late October she released a single with Mao. The song is called “Can’t Stop Love,” for the visual novel More Love. She will also in the concert event The Score Re;fire #1 ~WILD ARMS Vocal Songs Concert~ scheduled for December 15th. Lastly she will also be at the Yucat x Eggman: Diva 3Man volume 6 on January 21st. In more personal news she revealed she celebrated Yuriko Kaida’s birthday with Yuki Kajiura (no mention of Keiko, but a good chance she was there considering how much she loves Yuriko), and had drinks with Joelle and Yuki. You can see that post here: https://lineblog.me/odakaori/archives/13206078.html She also went to see Shinji Kakijima’s 25th Anniversary Live and had her picture taken with him late last month. She also got a haircut (nothing particularly drastic). Traditionally haircuts symbolize change and a break with the past, which considering her break with Spacecraft feels rather fitting. She also just got her nails done in a pale pink.

Koichi Korenaga is extremely busy! In late October to November 1st, Jungapop (which also has Jr.) did a small tour. This was for a newly released anniversary album 20+1. They also recorded some new songs in September. On November 10th he did a seminar on music equipment. He performed alongside Jr. for his solo 50th Anniversary on November 16th.  On November 23rd, he’s performing with others at the Rock ‘n Roll Yokohama Club. He has three tour dates for Crystal Kay for December 2nd, 3rd, and 6th. He is performing for NOKKO on December 19th and 25th (his birthday). He also is performing for Ami Ozaki on December 14th, 17th, and 24th. In his personal life, he had corrective eye surgery early this year, has been having physical therapy on his shoulders and arms (from his long guitar playing), and just celebrated his mother’s birth or death anniversary. The photo contained flowers and a cross necklace with Jesus hanging on it on a decorative cross. He states something along the line that he knows she’s in heaven as she was a good Christian. He also went to see the new movie about the rock band Queen.

Tomoharu Jr. Takahashi just performed his special solo 50th Anniversary for his 50th birthday on November 16th. This also included his Jungapop friends including Koichi Korenaga. In addition, he just released his first solo album.

Joelle has some concert dates lined up. She performed on November 9th and on October 21st. She has two more scheduled, one for December 19th and another for December 22nd. Some of these have her good friend George Nagata. She also just performed at 5:00AM for a local television station in her hometown of Akita. It was also her birthday in late October.

Yuriko Kaida released an EP called Portia earlier this year. She also went on vacation to Hanoi, Vietnam back in September with a close friend.

Remi and Koichi Korenaga worked on some songs for the anime Non Non Biyori Vacation. It seems she also worked on Boruto: Naruto Next Generations Soundtrack 2 released on November 7th. She seems to have been doing a lot of recording this year.

Rie Akagi has a Latin jazz concert trio scheduled for November 30th. She also responded to Hikaru’s twitter post on her eating rice.

Eri Itou performed in a musical called Musical Award that went from October 31st to November 4th.  She is also in a Christmas album that was released on November 14th. It was her birthday on November 16th.

Drummer Kyoichi Satou and keyboardist Hirotaka Sakurada will do a concert with others on January 22nd.

Hiroshi Konno has been recording and performing at various places with his strings unit. Much of the recording is likely for Yuki Kajiura. He also received Jr.’s album and a shirt.

[transfemstarscream]

Would you rank all of Starscream's voice (actors) so far? You can include Japanese and other languages if you want.

english voice actors:

chris latta

michael dobson

tom kenny

billy bob thompson

doug parker

sam rigel

frank todaro/charlie adler

steve blum

japanese voice actors:

jin yamanoi

hirotaka suzuoki

takaya kuroda

hiroki takahashi

nobuo tobita

kazuki yao

kunihiro kawamoto

tadashi miyazawa

setsuji satō

tomokazu sugita

satoshi tsuruoka

i would rank the woman who voiced her in the french dub around the mid-high ranks.

[genkais-arcade]

Yu Yu Hakusho: Poltergeist Report released on April 9, 1994.

Studio(s): Studio Pierrot and Movic

Director: Masakatsu Iijima

Producers: Haruo Sai, Ken Hagino, and Naoji Hōnokidani

Score: Yusuke Honma

I'll also list all of the artists involved in making the background art and the key animators! This movie looks incredible and directors tend to get a much bigger cut of the credit than they deserve.

Background Art: Emi Kitahara, Emiko Koizumi, Hideaki Kudo, Hirofumi Shiraishi, Hisae Saito, Hitoshi Nagasaki, Ikuko Ōoka, Kaoru Inoda, Kazuo Ebisawa, Kumiko Nagashima, Masumi Nishikawa, Mio Isshiki, Ryō Kōno, Sadayuki Arai, Sawako Takagi, Shigenori Takada, Shinichi Uehara, Shinobu Takahashi, Shuichi Hirose, Toshiharu Mizutani, Toshiyuki Yoshimura, Yasunari Usuda, Youngil Park, Yuka Kawashima, Yuka Okamoto, Yūko Kobayashi

Key Animation: Akihide Saitō, Chihiro Hayashi, Fuminori Kizaki, Hajime Kamegaki, Hideyuki Motohashi, Hikaru Takanashi, Hiroharu Nishida, Hiromi Niioka, Hirotaka Kinoshita, Hiroyuki Kanbe, Hiroyuki Okuno, Hisahito Natsume, Isao Sugimoto, Junichi Kigawa, Junko Abe, Kari Higuchi , Katsuichi Nakayama, Kazumi Minahiro, Kazuya Kuroda, Kazuyuki Ikai, Kazuyuki Kobayashi, Keiko Shimizu, Kenji Yamazaki, Kunihiko Ito, Mamoru Hosoda, Mamoru Kurosawa, Masahito Yamashita, Masaki Hosoyama, Masayuki Fujita, Mayumi Hirota, Munenori Nawa, Naoyuki Owada, Osamu Nabeshima, Satoru Iriyoshi, Satoshi Fukushima, Shinji Seya, Shinsaku Kōzuma, Shuji Kawakami, Shunji Suzuki, Susumu Yamaguchi, Tadakatsu Yoshida, Tadashi Abiru, Takashi Yamazaki, Takayuki Gorai, Takenori Mihara, Takuya Satō, Toyoaki Shiomi, Yasunari Nitta, Yoshiaki Tsubata, Yoshinori Kanada, Yoshiyuki Kishi, Yuichi Endo, Yuko Kusumoto

[leenaevilin]

[Pics]『ヒプノシスマイク-Division Rap Battle-』 Rule the Stage -Battle of Pride- (hypnosis mic -division rap battle- rule the stage -battle of pride-)

visuals update under the cut^^

Cast:

Ikebukuro Devision “Buster Bros!!!”

Takano Akira as Yamada Ichirou (山田一郎)

Matsuda Shouta as Yamada Jirou (山田二郎)

Akishima Ryuuto as Yamada Saburou (山田三郎)

Yokohama Devision “MAD TRIGGER CREW”

Abe Aran as Aohitsugi Samatoki (碧棺左馬刻)

Mizue Kenta as Iruma Juuto (入間銃兎)

Byrnes Yuuki as Busujima Meison Riou (毒島メイソン理鶯)

Shibuya Division “Fling Posse”

Sekoguchi Ryou as Amemura Ramuda (飴村乱数)

Maeyama Takahisa as Yumeno Gentarou (夢野幻太郎)

Takizawa Ryou as Arisugawa Daisu (有栖川帝統)

Shinjuku Division “Matenrou”

Ayukawa Taiyou as Jinguuji Jakurai (神宮寺寂雷)

Araki Hirofumi as Izanami Hifumi (伊弉冉一二三)

Miyagi Koudai as Kannonzaka Doppo (観音坂独歩)

Osaka Division “Dotsuitare Honpo”

Aramaki Yoshihiko as Nurude Sasara (白膠木簓)

Satonaka Masamichi as Tsutsujimori Roshou (躑躅森盧笙)

Higashiyama Yoshihisa as Amayado Rei (天谷奴零)

Nagoya Division “Bad Ass Temple”

Hirono Ryouto as Harai Kuukou (波羅夷空却)

Katou Daigo as Aimono Juushi (四十物十四)

Aoyagi Ruito as Amaguni Hitoya (天国獄)

Akabane Division “North Bastard“

Kishimoto Yuuta as Doan Kazusato (堂庵和聖)

Nanbu Kaito as Kokuri Ryozan (狐久里梁山)

Matsuuchi Tsukasa as Saragi Kenei (蛇穴健栄)

Asakusa Division “Onigawara Bombers”

Katou Ryousuke as Hoozuki Jinpachi (鬼灯甚八)

Wada Taisuke as Komagata Masamune (駒形正宗)

Yuuki Kazuya as Yougou Doshirou (影向道四郎)

Itonokai

Uenobori Makoto as Oogumo Danjou (大蜘蛛弾襄)

Doutonbori Divers

Hoshino Yuuta as Takanashi Haru (小鳥遊ハル)

Kitano Satsuki as Watamoto Hirotaka (綿本裕孝)

Takahashi Yuuri as Akanegakubo Ryoutarou (茜ヶ久保遼太郎)

homepage nelke natalie

[putschki1969]

Sword Art Online FULL DIVE 10th Anniversary Event Streaming Option

Just a reminder, Yuki Kajiura and her team will participate in the 10th Anniversary event “Sword Art Online -Full Dive-”, which will be held at Tokyo Garden Theater on November 6th. (Source)

[Date and time] November 6, 2022 [Venue] Tokyo Garden Theater [Participating Cast &Artists] Cast: Yoshitsugu Matsuoka, Haruka Tomatsu, Miyuki Sawashiro, Rina Hidaka, Kanae Ito, Aoi Yuki, Ai Kayano, Nobunaga Shimazaki, Hiroaki Hirata, Hiroki Yasumoto, Inori Minase Artists: Eir Aoi, ASCA, ReoNa, Luna Haruna, Yuki Kajiura

Participating Members: Yuki Kajiura (Piano) Vocals: Remi, KAORI, KEIKO, YURIKO KAIDA, Joelle MUSICIAN: FRONT BAND MEMBERS Koichi Korenaga (Guitar), Kyoichi Sato (Drums), Tomoharu “Jr.” Takahashi (Bass), Rie Akagi (Flute), Hirotaka Sakurada (Keyboard), Yoshio Ohira (Manipulator) -Hitoshi Konno Strings- Hitoshi Konno (Violin), Tomomi Tokunaga (Violin), Naomi Urushibara (Violin), Shiori Watanabe (Violin), Tomohiro Kobayashi (Viola), Takayoshi Okuizumi (Cello) 

■ Official Website: https://sao-p.net/ ■ 10th Anniversary Special Site: https://sao10th.net/ ■ Official Twitter account: https://twitter.com/sao_anime

Live Streaming Option for Overseas Fans

Streaming Platform: Stagecrowd Ticket price: 4,500 yen Purchase period: October 29 ~ November 13 Archive period: ~ November 13

If you are interested in this event, be sure to use the opportunity provided to overseas fans. Stagecrowd is a reliable service and many of you might already have an account (Keiko’s earliest events were held on this platform). I’ll personally sit this one out because there’s just too much going on that I don’t care for...

[aintnolionpridelands]

Promotional pictures of Allegiance Japanese production (2021)

March - April, 2021 | Tokyo / Nagoya / Osaka

濱田めぐみ Megumi Hamada (Kei Kimura) 海宝直人 Naoto Kaiho (Sammy Kimura) 中河内雅貴 Masataka Nakagauchi (Frankie Suzuki) 小南満佑子 Mayuko Kominami (Hannah Campbell) 上條恒彦 Tsunehiko Kamijo (Sam Kimura/Ojii-chan) 今井朋彦 Tomohiko Imai (Mike Masaoka) 渡辺徹 Toru Watanabe (Tatsuo Kimura)

照井裕隆 Hirotaka Terui, 西野誠 Nishino Makoto, 松原剛志 Tsuyoshi Matsubara, 俵和也 Kazuya Tawara, 村井成仁 Naruhito Murai, 大音智海 Tomomi Oto, 常川藍里 Airi Tsunekawa, 河合篤子 Atsuko Kawai, 彩橋みゆ Miyu Ayahashi, 小島亜莉沙 Arisa Kojima, 石井亜早実 Asami Ishii, 髙橋莉瑚 Rico Takahashi

Translation by 渋谷真紀子 Makiko Shibuya & 高橋知伽江 Chikae Takahashi Directed by Stafford Arima

[ddanadeai]

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181014 Big Tohoshinki Fan, Model and Actress Takahashi Yu

“Japanese model and actress Takahashi Yu is a long time fan of Tohoshinki and Yunho.

(Here is one of her blogs about them).

She appeared on NTV’s ‘Gyoretsuno dekiru horitsu sodanjo’ special episode hosted by Sanma-san, and told a story about how her husband, K-1 fighter Urabe Hirotaka, got jealous over a Tohoshinki post she made on her instagram story about them being cool/amazing and wanting to see their live!”

“While talking about Model Takahashi Yuu's newlywed life, she was asked if her husband feels jealous, too.

Takahashi Yuu: I like Tohoshinki so much, so around the time we got together, I posted on my IG story ‘Tohoshinki are so cool, I want to see their live’. He asked ‘What is that, Yuu-chan’.”

“She also told her story about how she celebrated Yunho's birthday with a cake. Text on the cake ‘Happy birthday Yunho-san’. She`s a long-time Yunho fan.”

From an interview from 2011

Q. What is your type?

Takahashi Yu: A romanticist. And I like older guys. I like Tohoshinki's Yunho!

“Plus there was an info before that she and her younger sister attended a Toho concert.”

[biseksuwal]

yu takahashi, the japanese pinay actress/model who was the first to play sailor jupiter/makoto kino in the 20th anniversary reboot of the sailor moon musicals, got engaged to japanense pinoy kickboxer hirotaka urabe and they are sf cute

View this post on Instagram

A post shared by 高橋ユウ (@takahashiyu.official) on Sep 16, 2018 at 4:45am PDT

[dsc4]

149 HIROTAKA TAKAHASHI [GLOOMY/TALENTED/SNOB]

a gloomy master vampire who happens to be a fast learner in many areas. he’s very loving to his family, maybe to the point of being a pushover for them. he first knew divya as his apartment neighbor, but their relationship gradually escalated into marriage partners. you can often find hiro in his bedroom crying, playing video games, or taking a nice bubble bath.

150 DIVYA TAKAHASHI [MEAN/AMBITIOUS/INSIDER]

a spellcaster who tends to forget she is a spellcaster. divya is more concerned with mortal affairs, like beating up blarffy or trying to figure out the clusterfuck of human emotions and relations. she also holds grudges well, though if no one would say this about her except divya herself. divya has known yuta longer than hiro, though this is a secret for the involved pair. 

151 JANHVI KUMAR [CREATIVE/CHILDISH/EXCITABLE]

janhvi is quite different from her sister in appearance and personality, but they’ve maintained a close relationship, as their parents passed away while they were young. janhvi immediately tends to follow up on her instincts, though tumaini sometimes advises her to think things over one more time. 

152 TUMAINI YOUNG [NATURALLY FUNNY/LONER/OPEN-MINDED]

unlike most of the takahashi/kumar family, tumaini is a normal human, though her general serenity and wisdom leads people to think otherwise. she quite enjoys being alone, but she often says that being alone is best enjoyed with a selective few (she interprets loneliness as another matter). despite being a loner, she has more friends than janhvi. tumaini and janhvi always have a different story to tell about how they started dating, but the core truth is that they met as adults and hit it off immediately.

159 MONCEF YOUNG [CLUMSY/SENSITIVE/LONER]

tumaini’s oldest son and aspiring trophy malewife/model/influencer. moncef was adopted as a teenager, but nevertheless is extremely attached to and adoring of his mother. his adoration is so overwhelming he avoided visiting her for months after promising to introduce her to his ex he had planned to marry; the plan obviously fell out, but he lacked the guts to tell his mother so. moncef’s appearance and clothing sense is deeply telling of his current mental state (beard, printed t-shirt, sandals; he’s faring terribly). moncef is suspicious of yuta but is unable to pinpoint the reason for it.

0XX YUTA TAKAHASHI [GEEK/SELF-ASSURED/PROPER]

hirotaka’s half-brother and a fellow vampire. yuta brands himself as “some guy,” though he may have the most interesting story to tell out of the members of his family. yuta personally considers himself more “manipulative” than “clever,” but since his means and end goals are often good, people neatly categorize him him as clever. he likes to stick in the shadows, directing the spotlight toward his family members.

154 MSHINDI KUMAR [GOOD/CREATIVE]

mshindi is a good kid with simple goals, maybe so good that he is seen as boring by some people’s standards. he isn’t bothered by that at all though, because he always has his gaze on his personal enjoyment of life. mshindi inherited tumaini’s meekness and control and janhvi’s aloofness.

155 TAICHI TAKAHASHI [ADVENTUROUS/MISCHIEVOUS]

a boy with a good head on his shoulders. though he excels academically and earned an excellence bunny for his efforts, taichi struggles with conveying his emotions. perhaps, the years of watching his mother and father’s domestic dramatics has created his emotional constipation.

161 NYOTA YOUNG [INQUISITIVE]

the newest edition to the kumar/young household. 

[your-dietician]

LRP5 and MTHFR gene variants with osteoarthritis prevalence

New Post has been published on https://depression-md.com/lrp5-and-mthfr-gene-variants-with-osteoarthritis-prevalence/

LRP5 and MTHFR gene variants with osteoarthritis prevalence

Masaki Nakano,1,* Haruka Yui,1,* Shingo Kikugawa,2 Ryosuke Tokida,3 Noriko Sakai,4 Naoki Kondo,5 Naoto Endo,5 Hirotaka Haro,6 Hiroki Shimodaira,1 Takako Suzuki,1,7 Hiroyuki Kato,1 Jun Takahashi,1 Yukio Nakamura1

1Department of Orthopaedic Surgery, Shinshu University School of Medicine, Matsumoto, Nagano, 390-8621, Japan; 2DNA Chip Research Inc., Minato-ku, Tokyo, 105-0022, Japan; 3Rehabilitation Center, Shinshu University Hospital, Matsumoto, Nagano, 390-8621, Japan; 4Department of Orthopaedic Surgery, New Life Hospital, Obuse, Nagano, 381-0295, Japan; 5Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Chuo-ku, Niigata, 951-8510, Japan; 6Department of Orthopaedic Surgery, University of Yamanashi Graduate School of Medicine, Chuo, Yamanashi, 409-3898, Japan; 7Department of Human Nutrition, Faculty of Human Nutrition, Tokyo Kasei Gakuin University, Chiyoda-ku, Tokyo, 102-8341, Japan

Correspondence: Yukio Nakamura Department of Orthopaedic Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan Tel +81-263-37-2659 Fax +81-263-35-8844 Email [email protected]

Objective: Osteoarthritis (OA) is a common and degenerative joint disorder in the elderly. A greater importance of understanding the relationship between genetic factors and OA prevalence has emerged with population aging. We therefore investigated the associations of several bone disease-related genetic variants with the prevalence of OA and osteoporosis in Japanese elderly women from the Obuse study cohort, which was randomly sampled from a basic town resident registry. Methods and Results: In total, 206 female participants (mean ± standard deviation age: 69.7 ± 11.0 years) who completed OA, bone mineral density, and genotype assessments were included. The number of patients diagnosed as having knee/hip OA and osteoporosis was 59 (28.6%) and 30 (14.6%), respectively. Fisher’s exact testing revealed significant relationships between the minor T allele of LDL receptor related protein 5 (LRP5) rs3736228 and the prevalence of knee/hip OA and osteoporosis. The respective odds ratios (ORs) of the TT genotype for knee/hip OA and osteoporosis were 7.28 (95% confidence interval [CI] 2.22– 28.08) and 5.24 (95% CI 0.95– 26.98). An additional subgroup analysis for knee OA revealed that the frequency of the common C allele of methylenetetrahydrofolate reductase (MTHFR) rs1801133 had a statistically significant protective association with the prevalence of knee OA (OR 0.58, 95% CI 0.35– 0.97). Conclusion: In sum, the present study demonstrated significant associations of LRP5 rs3736228 and MTHFR rs1801133 with knee/hip OA and osteoporosis prevalences and knee OA prevalence, respectively, in Japanese elderly women. These results will help further the understanding of OA pathogenesis and related genetic risk factors.

Introduction

Osteoarthritis (OA) is a common degenerative joint disorder occurring with age whose pathophysiology remains incompletely understood. At present, almost all non-surgical treatment options for OA are limited to analgesis and improving joint movement, with no fundamental cures.1 Osteoporosis is a widespread metabolic skeletal disease characterized by diminished bone mineral density (BMD) or bone strength, both of which increase the risk of fractures. Although several effective medications exist,2 both osteoporosis and OA are becoming major worldwide health concerns with population aging and rising health-care costs. Therefore, understanding the genetic risk factors for these disorders has emerged as an important issue for disease prevention and therapeutic management.

Many studies on the association of genetic factors with OA and osteoporosis have been reported to date. In the present day, the relationships among genetic variants and related disorders are generally investigated by genome-wide association studies (GWAS). Regarding the prevalence of OA and osteoporosis, 256 and 22 records, respectively, were found in the GWAS catalog (https://www.ebi.ac.uk/gwas/).3 Several gene polymorphisms appear to affect OA as well as osteoporosis. Indeed, associations of gene variants in LDL receptor related protein 5 (LRP5),4,5growth differentiation factor 5 (GDF5),6,7 and SMAD family member 3 (SMAD3)8,9 with OA prevalence have been reported. In addition, we very recently uncovered a novel association between a homocysteine metabolism-related methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism (rs1801133), which was reportedly related to osteoporosis, and the progression of spinal OA.10

We have recently established a new population-based epidemiological study of Japanese people that employs random sampling from the basic resident registry of Obuse, a rural town in Japan.11,12 The Obuse study contains detailed medical information on the community-dwelling elderly population with minimized selection bias, which allows for examination of a cohort representative of the general population. The present study aimed to investigate the associations of several reported bone disease-related genetic variants, including MTHFR rs1801133, with the prevalence of OA and osteoporosis in elderly women sampled from the Obuse study cohort. Significant associations were seen for LRP5 rs3736228 with the prevalence of knee/hip OA and osteoporosis, and for MTHFR rs1801133 with knee OA prevalence in Japanese elderly women.

Methods

The study protocol of this investigation for human research was approved by the investigational ethics review board of Shinshu University Hospital, Japan (approval number: 2792). The research procedure was carried out in accordance with the ethical guidelines of the 2013 Declaration of Helsinki. Written informed consent for research and publication was provided by all participants prior to the initiation of the study.

Study Subjects

The Obuse study was launched in October 2014 for epidemiological data collection until June 2017. The study randomly sampled 1297 male and female individuals from 5352 members of the resident population between 50–89 years of age in the basic resident registry of Obuse town (Nagano Prefecture, Japan) as a joint collaboration with the cooperating town office. In total, 203 male and 212 female participants provided written informed consent and were enrolled in the Obuse study. The current investigation included 206 female subjects who completed assessments of knee and hip OA, BMD measurements of the total hips and lumbar spine, and genotype determination of the gene variants of interest. Due to budget constraints, we analyzed only female subjects who were susceptible to systemic skeletal disorders including OA and osteoporosis compared to males.

Assessment of OA and Osteoporosis

OA of the knee and hip was assessed by radiographic examination. The degree of degeneration was evaluated in accordance with the Kellgren–Lawrence (KL) grading system.13 Radiographs were examined by 2 experienced orthopaedic surgeons (H.S. and Y.N.). The subjects with the worst KL grading of ≥ 3 in either side of the knees or hips, or who had undergone arthroplasty for OA were judged as OA patients. The subjects with persistent joint pain and tenderness were also radiologically assessed as having OA. BMD at the lumbar spine and hips was measured using dual-energy X-ray absorptiometry (DXA; PRODIGY, GE Healthcare, Chicago, IL). The regions of interest for lumbar and hip BMD were the L2–4 spinal and bilateral total hip regions, respectively. Subjects with BMD values of ≤ 70% of the young adult mean (YAM) for either the lumbar region or total hips were diagnosed as having osteoporosis.14

Determination of Genetic Variants

Cell-free DNA (cfDNA) was extracted from plasma samples of study subjects using a QIAamp Circulating Nucleic Acid Kit (Qiagen, Venlo, Netherlands) according to the manufacturer’s instructions. Genotyping assays were performed by a droplet digital polymerase chain reaction (ddPCR) QX200 system (Bio-Rad, Hercules, CA). Reaction mixture aliquots of 20 µL containing 10 µL 2 × ddPCR Supermix, 5 µL cfDNA sample, and 0.5 µL 40 × TaqMan SNP Genotyping Assay for each variant (Applied Biosystems, Waltham, MA) were prepared. The droplets were generated with a QX200 droplet generator and carefully transferred to 96-well PCR plates. After PCR cycling (40 cycles of 94°C for 30 s and 60°C for 1 min), the fluorescence of each droplet was determined using a QX200 droplet reader followed by analysis with QuantaSoft version 1.7.4 software (Bio-Rad). The present study examined the following genetic variants: LRP5 rs312009 and rs3736228, GDF5 rs143383, SMAD3 rs12901499, and MTHFR rs1801133.

Statistical Analysis

The background characteristic data of each study group (healthy control, OA, osteoporosis, and comorbid with OA and osteoporosis) are presented as the mean ± standard deviation (SD) together with the median value. Fisher’s exact test was performed to calculate the odds ratio (OR) and 95% confidence interval (CI) of variant genotypes and alleles for the prevalence of OA and osteoporosis versus healthy controls. To examine the population homogeneity of the study participants, Haldane’s exact test for Hardy–Weinberg equilibrium (HWE) was calculated. All statistical tests were carried out by using R version 3.4 software.15 A two-tailed P-value of < 0.05 was considered statistically significant in this study.

Results

Background Characteristics of Study Subjects

The average ± SD age of the 206 female subjects at enrollment was 69.7 ± 11.0 years. The number of patients diagnosed as having OA and osteoporosis was 51 (24.8%; knee: 40, hip: 3, knee and hip: 8) and 22 (10.7%), respectively. Eight patients (3.9%) suffered from both osteoporosis and OA (knee: 6, hip: 1, knee and hip: 1) and were classified into the comorbid group. One hundred and twenty-five subjects having neither OA nor osteoporosis were defined as healthy controls in this study. The background characteristics of the study groups are summarized in Table 1.

Table 1 Background Characteristics of the Study Groups

Associations of Genotype and Allele Frequencies with OA and Osteoporosis

In the present cohort, we observed no remarkable associations for LRP5 rs312009, GDF5 rs143383, or SMAD3 rs12901499 with both OA and osteoporosis prevalence (Tables 2 and 3 and Figures 1 and 2). In contrast, the minor T allele of LRP5 rs3736228 and its homozygotic genotype showed significant relationships with the prevalence rate of knee/hip OA. The ORs of the TT genotype and T allele for OA compared with healthy controls were 7.28 (95% CI 2.22–28.08; P < 0.001) and 1.80 (95% CI 1.07–3.00; P < 0.05), respectively (Table 2 and Figure 1). Although not significantly, the common C allele of MTHFR rs1801133 tended to protect against knee/hip OA prevalence. The respective ORs of the CC genotype and C allele for OA were 0.55 (95% CI 0.23–1.22; P = 0.15) and 0.70 (95% CI 0.43–1.14; P = 0.13) versus the healthy control group (Table 2 and Figure 1). The prevalence rate of osteoporosis was significantly correlated with the TT genotype of LRP5 rs3736228 (OR 5.24, 95% CI 0.95–26.98; P < 0.05) (Table 3 and Figure 2). The distributions of genotype frequencies were in Hardy–Weinberg equilibrium (HWE P-value > 0.05).

Table 2 Genotype and Allele Frequencies in Patients with Osteoarthritis

Table 3 Genotype and Allele Frequencies in Patients with Osteoporosis

Figure 1 Odds ratios for osteoarthritis by each variant genotype. Fisher’s exact test was employed to calculate the odds ratio and 95% confidence interval of variant genotypes for the prevalence of osteoarthritis versus the healthy control group.

Abbreviations: LRP5, LDL receptor related protein 5; GDF5, growth differentiation factor 5; SMAD3, SMAD family member 3; MTHFR, methylenetetrahydrofolate reductase.

Figure 2 Odds ratios for osteoporosis by each variant genotype. Fisher’s exact test was employed to calculate the odds ratio and 95% confidence interval of variant genotypes for the prevalence of osteoporosis versus the healthy control group.

Abbreviations: LRP5, LDL receptor related protein 5; GDF5, growth differentiation factor 5; SMAD3, SMAD family member 3; MTHFR, methylenetetrahydrofolate reductase.

Subgroup Analysis for Knee OA Prevalence

In a subgroup analysis, we focused on the prevalence of knee OA, which was the most common disorder witnessed in this study. In knee OA only or knee OA + comorbid osteoporosis patients, both the TT genotype (P < 0.001) and T allele (P < 0.05) of LRP5 rs3736228 associated significantly with knee OA prevalence as compared with healthy controls (Table 4). Moreover, the C allele of MTHFR rs1801133 demonstrated a statistically significant protective association with the prevalence rate of knee OA (OR 0.58, 95% CI 0.35–0.97; P < 0.05) in the knee OA + comorbid osteoporosis subgroup (Table 4).

Table 4 Subgroup Analysis of Patients with Knee Osteoarthritis

Discussion

This study demonstrated a significant relationship between LRP5 rs3736228 and the skeletal disorders of OA and osteoporosis in elderly community-dwelling female residents randomly sampled from a Japanese town resident registry. A statistically significant protective association of the common allele of MTHFR rs1801133 with knee OA prevalence was also observed. As the population sampling of our cohort minimized selection bias, our results might be considered reflective of the Japanese general population.

LRP5 and 6 (LRP5/6) are required as co-receptors for canonical Wnt signaling16,17 and play important roles in skeletal development and metabolism. A number of LRP5 gene variants have been reported. Of those, associations of the missense variants LRP5 rs3736228 (Ala1330Val) and rs4988321 (Val667Met) with decreased BMD and the risk of osteoporotic fracture are well described.18,19 In particular, a relationship between LRP5 A1330V and diminished BMD has been identified in the Japanese population as well.20,21 A loss of function in LRP5 increased cartilage degradation in a mouse model22 and was also suggested to be associated with OA. However, little is known on the precise connection between OA and LRP5 gene variants. Although associations of LRP5 rs41494349 (Gln89Arg) with spinal OA4 and LRP5 rs3736228 with knee OA5 have been reported, no information has been recorded in the GWAS catalog to date (https://www.ebi.ac.uk/gwas/).3 Therefore, the findings of this study demonstrating a relationship between the T allele of LRP5 rs3736228 and knee/hip OA prevalence in a randomly sampled population cohort will be of value for further understanding the relationship between OA development and the pathophysiological role of LRP5 dysfunction.

In the subgroup analysis for knee OA, there was a protective association for the common C allele of MTHFR rs1801133 (Ala222Val) rather than a risk association of the minor T allele with the prevalence rate of knee OA. MTHFR is known to act within the methionine cycle and plays an essential role in homocysteine clearance. A functional deficiency of the MTHFR enzyme leads to mild elevation of circulating homocysteine levels.23 The A222V missense variant is a common mutation in the MTHFR gene that causes dysfunctional enzymatic activity. Notably, the T allele of MTHFR rs1801133 has been implicated in decreased BMD and the occurrence of osteoporotic fractures,24,25 and we very recently uncovered a relationship among homocysteine, MTHFR rs1801133, and spinal OA in Japanese postmenopausal women.10 The results of the present study imply a correlation between diminished homocysteine levels and a lowered risk of knee OA prevalence. Since circulating homocysteine levels can be decreased by vitamin B group supplementation,26 the significance of B-vitamins intervention in individuals bearing the T allele of MTHFR rs1801133 for preventing OA development may warrant further investigation.

An intron variant of LRP5 gene rs312009 as well as GDF5 rs143383 and SMAD3 rs12901499 showed no remarkable correlations with OA or osteoporosis prevalence in this study. The rs143383 is located in the 5′-untranslated region core promotor of GDF5, which encodes a chondrogenic protein. A relationship of rs143383 with OA has been demonstrated in various racial groups, including a Japanese cohort.6,7 On the other hand, SMAD3 is a member of the SMAD family of proteins and plays an essential role in mediating the transforming growth factor-beta signaling pathway. A genetic variant, rs12901499, within the intron 1 of SMAD3 is reportedly associated with OA in Caucasian and Asian populations.8,9 However, other studies have shown no relationship for either GDF5 rs143383 or SMAD3 rs12901499 with OA prevalence.27,28 Relatively small number of samples limited to female subjects is a limitation of the current study. Besides, although the subjects were randomly sampled from a resident registry, there was a potential for selection bias due to the low participation rate (32.0%) as a result of the noncompulsory survey design. Furthermore, since it sampled from a single town in Japan, this study might contain local features that should be considered when interpreting the data. Future studies with larger sample size and male subjects that include multiple regions in Japan and/or other Asian countries will overcome the controversial issues. Further investigations including experimental study on the mechanisms and/or pathways will be required as well.

Conclusion

We observed significant associations of LRP5 rs3736228 and MTHFR rs1801133 with knee/hip OA and osteoporosis prevalences and knee OA prevalence, respectively, in Japanese elderly women from the randomly sampled Obuse study cohort. The results of the present study will help further the understanding of OA pathogenesis and related genetic risk factors, which will contribute to improved disease prevention and therapeutic management.

Acknowledgments

This work was supported by a grant from the JOA-Subsidized Science Project Research 2018–2020 to Y.N. We would like to thank Dr. Takashi Igarashi of the Center for Clinical Research at Shinshu University Hospital, Dr. Hironobu Sato of the Obuse Town Institute for Community Health Promotion, and the Obuse Town Office for sample selection in this study. Our gratitude extends to Mr. Trevor Ralph for English language editing as well as all participants in the present study.

Disclosure

All of the authors have declared that there were no conflicts of interest in this study.

References

1. Hunter DJ, Bierma-Zeinstra S. Osteoarthritis. Lancet. 2019;393(10182):1745–1759. doi:10.1016/S0140-6736(19)30417-9

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6. Miyamoto Y, Mabuchi A, Shi D, et al. A functional polymorphism in the 5’ UTR of GDF5 is associated with susceptibility to osteoarthritis. Nat Genet. 2007;39(4):529–533. doi:10.1038/2005

7. Chapman K, Takahashi A, Meulenbelt I, et al. A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5’ UTR of GDF5 with osteoarthritis susceptibility. Hum Mol Genet. 2008;17(10):1497–1504. doi:10.1093/hmg/ddn038

8. Valdes AM, Spector TD, Tamm A, et al. Genetic variation in the SMAD3 gene is associated with hip and knee osteoarthritis. Arthritis Rheum. 2010;62(8):2347–2352. doi:10.1002/art.27530

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12. Tokida R, Ikegami S, Takahashi J, et al. Association between musculoskeletal function deterioration and locomotive syndrome in the general elderly population: a Japanese cohort survey randomly sampled from a basic resident registry. BMC Musculoskelet Disord. 2020;21(1):431. doi:10.1186/s12891-020-03469-x

13. Ball J, Jeffrey MR, Kellgren JH, Editors. The Epidemiology of Chronic Rheumatism: Atlas of Standard Radiographs of Arthritis. Oxford, UK: Blackwell Scientific Publications; 1963.

14. Soen S, Fukunaga M, Sugimoto T, et al. Japanese society for bone and mineral research and japan osteoporosis society joint review committee for the revision of the diagnostic criteria for primary osteoporosis. Diagnostic criteria for primary osteoporosis: year 2012 revision. J Bone Miner Metab. 2013;31(3):247–257. doi:10.1007/s00774-013-0447-8

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20. Ezura Y, Nakajima T, Urano T, et al. Association of a single-nucleotide variation (A1330V) in the low-density lipoprotein receptor-related protein 5 gene (LRP5) with bone mineral density in adult Japanese women. Bone. 2007;40(4):997–1005. doi:10.1016/j.bone.2005.06.025

21. Urano T, Shiraki M, Usui T, Sasaki N, Ouchi Y, Inoue S. A1330V variant of the low-density lipoprotein receptor-related protein 5 (LRP5) gene decreases Wnt signaling and affects the total body bone mineral density in Japanese women. Endocr J. 2009;56(4):625–631. doi:10.1507/endocrj.K09E-133

22. Lodewyckx L, Luyten FP, Lories RJ. Genetic deletion of low-density lipoprotein receptor-related protein 5 increases cartilage degradation in instability-induced osteoarthritis. Rheumatology. 2012;51(11):1973–1978. doi:10.1093/rheumatology/kes178

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Fate/Grand Order MOD APK 2.13.3 (High Damage) Download Latest For Android

Fate/Grand Order MOD APK Introduction and Description : Here is file to Download The Latest Apk Version of Fate/Grand Order MOD, A popular game on play store For Android. Download Now for high damage feature! Description: Fate's RPG by TYPE-MOON, familiar on TV! You can enjoy full-scale RPG on your smartphone. A story where you can enjoy the overwhelming volume of over 5 million characters! In addition to the main story, we have prepared a story for each character, so that Fate fans will be fully satisfied even if they experience the world of Fate for the first time this time. Year 2015. Chaldea, who observes the future of the earth, confirmed the fact that human history has collapsed since 2017. The "promised future" up to 2115, which certainly existed yesterday, suddenly disappeared without any warning. why. why. who. how. AD 2004 Japan is a local city. I heard that an unobservable region has appeared here that has never existed before. Laplace assumed that this was the cause of human extinction and decided to carry out the sixth experiment, which was still in the experimental stage. It's a time trip to the past. A forbidden ritual that elucidates or destroys the singularity of spacetime by making humans spiritualized and sending them to the past and intervening in events. Its name is Human Rights Order, Grand Order. It is a collective term for those who fight fate and confront human history to protect humanity. Easy-to-use command order battle optimized for smartphones! The player becomes the master and manipulates the spirits to defeat the enemy and solve the mystery. Whether you fight with your favorite spirit or with a strong spirit The battle style depends on the player. ◆ Overall structure, scenario, general director Nasu mushroom ◆ Lead Character Designer Takashi Takeuchi ◆ Art Direction TYPE-MOON ◆ Scenario writing Yuichiro Higashide, Hikaru Sakurai Hazuki Minase, starry sky (TYPE-MOON) ◆ Guest writer Gen Kakubuchi (Nitroplus), acpi, experience value, Ukyo Kotachi, Makoto Mita, Tachibana Corp., Ryogo Narita, Hiroshi Hiroyama, Samurai Enjo, Ryo (in alphabetical order) ◆ Character design I-IV, Takatsuki Sogetsu (TYPE-MOON), AKIRA, Azusa, Towaku, Wilderness, Akira Ishida, Takeshi Okazaki, okojo, Itowa Kato, Kotori Kirihara, Ginka, Kuroboshi Kohaku, Otsuji Konoe, Komatsuzaki, Hiro Koyama Kazu (TYPE-MOON), saitom, Mine Sakamoto, Sasaki Shonen, Sate, Striped Udon (TYPE-MOON), Shimadoriru, sime, Shimoetsu (TYPE-MOON), Shirabi, Shinjiro, Makoto Soga, Taiki, Keitaro Takahashi, Minoh Takayama, Hojin Taketake, Task Owner, danchao, Chuo East Exit, Yuta, Dd, Sky Sphere, toi8, Nakahara, Namaniku ATK (Nitroplus), Nekotawa, pako, Takeda Harada, Haruno Haruno Tomoya, Bsuke, left, Rei Hiroe, Hiroshi Hiroyama, PFALZ, huke, BLACK (TYPE-MOON), Kanichi Koumi, BUNBUN, hou, Raita Honjo, Hirotaka Maeda, Matsuryu, Miho Midorikawa, Miwa Shiro, Motomura, Shiori Morii, Daisuke Moriyama, Totetsu Yamanaka, Yuki Yoko, La-na, lack, Ryo, Ryota-H, redjuice, Redrop, dullness, Wadaaruko (Japanese alphabetical order) A smartphone or tablet device with Android 4.1 or later, required RAM 2GB or more, recommended RAM 3GB or more. (Intel CPU is not supported) * Some models may not work even with the recommended version or higher. * N-08D / SH-06D are not supported. * The OS released as a beta version is not supported. "CRIWARE (TM)" of CRI / Middleware Co., Ltd. is used for this application. Fate's RPG sent by TYPE-MOON, familiar on TV! You can enjoy a full-fledged RPG on your smartphone. A story where you can enjoy the overwhelming volume of over 5 million characters! In addition to the main story, a story is prepared for each character, and it is a content that will satisfy Fate fans even if they are experiencing the world of Fate for the first time this time. AD 2015. Chaldea, observing the future of the earth, confirmed that human history since 2017 has collapsed. The “promised future” up to 2115, which did exist until yesterday, suddenly disappeared without any warning. why. why. who. how. AD 20042004Japan A local city. And A new “unobservable area” has emerged. Laplace assumed that this was the cause of human extinction and decided to carry out the sixth experiment, which was still experimental. It's a time trip to the past. .. A forbidden ceremony that elucidates or destroys the singularity of space-time by intervening in events by sending humans into spirits and sending them to the past. To Personal protection order, grand order. Total It is a collective term for those who struggle with fate and confront human history to protect humanity. Command Easy operation command order battle optimized for smartphone! Players become masters and control heroes to defeat enemies and unravel mysteries. Battle Fighting with your favorite hero or fighting with a strong hero depends on the player. Screenshots of Fate/Grand Order MOD APK

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FateGrand Order 2.13.3 screenshots 5 Fate/Grand Order MOD APK File Information: App Name Fate/Grand Order App Ratings 9.1 Latest Version 2.13.3 Operating System Android 4.1+ App Downloads 1,000,000+ Last Updated 2020-05-29 How to Install Fate/Grand Order MOD APK : Here are some easy steps from which you can install this game on your Android. Then the first thing that you need is to uninstall the previous version of Fate/Grand Order . Then click on the download button to download the file. Tap on the MOD APK file and click on the install. Allow Unknown resources for the installation of the app. Go to ->Setting ->Security -> Unknown Sources -> Turn it ON. Like in the picture below

If you are facing any issue in downloading or installation ,please comment below , so we can solve issue ASAP, Thanks. Read the full article