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#GAME *FUCKING* GOOD
chiangyorange · 20 days
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the chain but on a scale of who says hooray yippee and wahoo
is this anything.
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musubiki · 2 months
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balor 🥰
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some good news!! the spanish state's ministry of equality has finally passed one of the most progressive trans laws on the planet, shielded free and universal access to abortion and banned conversion therapy and genital surgery for intersex babies, among a lot of other feminist policies. the minister of equality irene montero gave a speech thanking spain's lgtb and trans associations for helping her draft these legislations. couldn't be more proud!!
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So Act 3 is going great,
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girlwiththegreenhat · 2 months
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team fortress 2 finally getting rid of the bots after 5 years
work on the team fortress 2 comic continuing after 7+ years
half life 3 development looking more likely than ever with legitimate code, file, and voicework leaks referencing a new non-VR single-player game from valve featuring a HEV suit wearing protagonist and Xen creatures and concepts
shoutout to the valve fan that found the genie lamp. you a real one
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wyrmswears · 9 months
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??lego ninjas
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reasonsforhope · 2 months
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"A large clinical trial in South Africa and Uganda has shown that a twice-yearly injection of a new pre-exposure prophylaxis drug gives young women total protection from HIV infection.
The trial tested whether the six-month injection of lenacapavir would provide better protection against HIV infection than two other drugs, both daily pills. All three medications are pre-exposure prophylaxis (or PrEP) drugs.
Physician-scientist Linda-Gail Bekker, principal investigator for the South African part of the study, tells Nadine Dreyer what makes this breakthough so significant and what to expect next.
Tell us about the trial and what it set out to achieve
The Purpose 1 trial with 5,000 participants took place at three sites in Uganda and 25 sites in South Africa to test the efficacy of lenacapavir and two other drugs.
Lenacapavir (Len LA) is a fusion capside inhibitor. It interferes with the HIV capsid, a protein shell that protects HIV’s genetic material and enzymes needed for replication. It is administered just under the skin, once every six months.
The randomised controlled trial, sponsored by the drug developers Gilead Sciences, tested several things.
The first was whether a six-monthly injection of lenacapavir was safe and would provide better protection against HIV infection as PrEP for women between the ages of 16 and 25 years than Truvada F/TDF, a daily PrEP pill in wide use that has been available for more than a decade.
Secondly, the trial also tested whether Descovy F/TAF, a newer daily pill, was as effective as F/TDF...
The trial had three arms. Young women were randomly assigned to one of the arms in a 2:2:1 ratio (Len LA: F/TAF oral: F/TDF oral) in a double blinded fashion. This means neither the participants nor the researchers knew which treatment participants were receiving until the clinical trial was over.
In eastern and southern Africa, young women are the population who bear the brunt of new HIV infections. They also find a daily PrEP regimen challenging to maintain, for a number of social and structural reasons.
During the randomised phase of the trial none of the 2,134 women who received lenacapavir contracted HIV. There was 100 percent efficiency.
By comparison, 16 of the 1,068 women (or 1.5%) who took Truvada (F/TDF) and 39 of 2,136 (1.8%) who received Descovy (F/TAF) contracted the HIV virus...
What is the significance of these trials?
This breakthrough gives great hope that we have a proven, highly effective prevention tool to protect people from HIV.
There were 1.3 million new HIV infections globally in the past year. Although that’s fewer than the 2 million infections seen in 2010, it is clear that at this rate we are not going to meet the HIV new infection target that UNAIDS set for 2025 (fewer than 500,000 globally) or potentially even the goal to end Aids by 2030...
For young people, the daily decision to take a pill or use a condom or take a pill at the time of sexual intercourse can be very challenging.
HIV scientists and activists hope that young people may find that having to make this “prevention decision” only twice a year may reduce unpredictability and barriers.
For a young woman who struggles to get to an appointment at a clinic in a town or who can’t keep pills without facing stigma or violence, an injection just twice a year is the option that could keep her free of HIV.
What happens now?
The plan is that the Purpose 1 trial will go on but now in an “open label” phase. This means that study participants will be “unblinded”: they will be told whether they have been in the “injectable” or oral TDF or oral TAF groups.
They will be offered the choice of PrEP they would prefer as the trial continues.
A sister trial is also under way: Purpose 2 is being conducted in a number of regions including some sites in Africa among cisgender men, and transgender and nonbinary people who have sex with men.
It’s important to conduct trials among different groups because we have seen differences in effectiveness. Whether the sex is anal or vaginal is important and may have an impact on effectiveness.
How long until the drug is rolled out?
We have read in a Gilead Sciences press statement that within the next couple of months [from July 2024] the company will submit the dossier with all the results to a number of country regulators, particularly the Ugandan and South African regulators.
The World Health Organization will also review the data and may issue recommendations.
We hope then that this new drug will be adopted into WHO and country guidelines.
We also hope we may begin to see the drug being tested in more studies to understand better how to incorporate it into real world settings.
Price is a critical factor to ensure access and distribution in the public sector where it is badly needed.
Gilead Sciences has said it will offer licences to companies that make generic drugs, which is another critical way to get prices down.
In an ideal world, governments will be able to purchase this affordably and it will be offered to all who want it and need protection against HIV."
-via The Conversation, July 3, 2024
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bananafire11 · 4 months
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Tadc..... dinosaurs.... tadc dinosaurs
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channnel · 3 months
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What if they were friends 🥹
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saragrosie · 7 days
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I was ltr just drawing them in swapped outfits cuz ya know disco is canon in Yakuza 0 and then bam they fucking Harry Du Bois'd Majima and ive never been more hyped for a video game in my life
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Expect to see more of this in non shitpost style (yes I lowered the graphics on kiryu and majima im tired) bc I love disco fashion and RGG and DE <3
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clarionglass · 4 months
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here we go :) part one of three, updates to be released weekly!
---
sam says 4 (game master cinematic universe, part 3)
Ruby was at her mum's for a family dinner she couldn't miss on pain of death, apparently, and the Doctor was many things, but a family dinner kind of guy wasn't one of them—particularly when Carla had already slapped him once in the short time he'd known her. He thought he'd broken his streak of bad luck with mums, but… well, seemingly not. So he was companionless for a few hours, and while he could wait for her to get back, maybe catch up on his reading—what was the point of waiting when you had a time machine? 
He ran his hands over the TARDIS console, marvelling at her clean lines and metallic flourishes, the way that even now she felt brand new but familiar, and paused. He’d just pop off for a quick adventure, nothing too dangerous, but—where to go?
He could scan for a distress call nearby, and pitch in to help. He could drop in on Donna and Shaun and Rose, beautiful Rose, and see how they were all doing. Or he could just hit the randomiser button, and jump in feet first wherever he ended up.
He remembered a conversation from a long time ago, when he wore a different face, and his gorgeous TARDIS wore a face too, for the first and only time.
“You didn't always take me where I wanted to go.”
“No, but I always took you where you needed to go.”
He grinned. Who could resist an offer like that? He pressed the button and whooped as the time rotor spun into action, ready to see where the universe would take him.
---
Apparently, he was needed pretty close to where he already was. Earth, 2024. Huh. Same planet, same time—within a few months of where he’d left Ruby, even. The main thing that had changed was the location: he was now in the good old US of A. California, to be more specific, and Los Angeles to be more specific still. And to really narrow it down, the Doctor discovered as he poked his head out of the TARDIS doors, he was in… a broom closet. Not bad, as a parking spot—a bit squeezy, but out of the way. And as he poked his head out of that door, he could finally see he was in the backstage corridors of a studio of some kind. Film or TV, if he was to hazard a guess, it was a different vibe from Abbey Road.
With a shrug, he decided to go exploring.
It couldn’t have been more than a minute before a young woman wearing the full-black outfit, headset, and permanently stressed expression of a production assistant came running up to him.
“Are you the fill-in Sam organised?” she asked breathlessly, and honestly, seeing the look on her face, the Doctor didn’t have the heart(s) to tell her no. And really, what was the Doctor, if not a professional fill-in? This, this was why he had a randomiser button on the control panel, because whatever he was about to get himself into was going to be fun.
“Sure!”
“Oh, thank god,” sighed the production assistant, relief dawning across her face. “When Ally tested positive this morning, I thought we were sunk for the record, because we called around and we couldn’t get a hold of anyone. But then Sam said he could get someone in, and, you know, here you are, and just in time, so—ah, yeah, if you could follow me this way?”
Smiling all the way, the Doctor followed his guide through to hair and makeup, looking around as they went. The studio seemed to belong to a company called Dropout, according to the branding scattered around, and things seemed, at least on the surface, to be… well. Fine. He couldn't tell why he'd been brought here yet, which meant that when he found the reason, it was going to be particularly tangled. He couldn't wait! 
And then he looked back at his guide, still engulfed in a miasma of anxiety, and realised he'd been too busy looking for clues to notice the person right in front of him. 
“Hey, it's cool, you've found me,” he started with a gentle smile. “You can relax. Hi, I'm the Doctor. What's your name?”
“Oh!” she said, startled. “The Doctor, yeah, of course. Um, hi, I'm Kaylin. Look, sorry, it's just that I've been so busy this morning, I'm so distracted… Shit, and I would've completely forgotten to get your details too. There's paperwork to fill in, but you can do that later. Um, just for now, though, can I get your pronouns?”
The Doctor thought for a moment. “He/him, for now.”
Kaylin nodded, making a note on her phone. “Okay, cool! And do you have any socials?”
“Not me, babes,” he replied. “I'm hardly sitting down long enough to be able to update, you know?”
“On a day like this, I know exactly what you mean,” she said. “That's okay, Lou didn't have socials either for the longest time. Right, so if you go through there, the team will get you sorted, and once you're done, someone will take you up to the greenroom. All good?”
“All great,” the Doctor replied. Kaylin flashed him a quick, relieved smile, then hurried off.
Hair and makeup was a fairly quick process, the sound mixer fitted him with a microphone, and before too long, Kaylin was back to take him upstairs. 
“This is the greenroom,” she said, pushing the door open. “The rest of the cast for the episode are already here—they’re great guys, and they’ve both been on the show a lot, so they’ll be able to help if you’ve got questions. And if you need anything else, just come find me or any of the other PAs, okay?”
The Doctor nodded, beamed at Kaylin, and walked in.
---
The greenroom was small but comfortable, and its occupants, two men around the same age as the Doctor appeared, looked up as he entered.
“Oh, you’re new,” the taller of the pair said, clearly giving him the once-over.
The other sighed with a mixture of fondness and exasperation, just as clearly used to his friend’s antics.
“Hey, I’m Brennan,” he said, levering himself up to standing from his perch on a chair arm, and holding out a hand. “That’s Grant.”
The Doctor took it warmly. “The Doctor. Just passing through, and happy to help.”
Grant’s eyebrows quirked. “Doctor… something?” he prompted.
“Or is it just ‘the Doctor’?” Brennan asked.
“Just ‘the Doctor’,” the Time Lord confirmed cheerfully. “You’ll get used to it, everyone does.”
Grant didn’t look convinced, but—
“Copy that,” Brennan shrugged, and settled back on the arm of the chair, returning his gaze to the door.
Grant, in turn, looked at the Doctor and rolled his eyes in a clear expression of ‘no, I don’t know why he’s like this, either’.
“Okay,” the Doctor said after a moment of watching the watching. “I wasn’t going to ask, but now I think I have to. What’s up with the door?”
Brennan huffed a laugh. “Well, the last time there was one of those up—” he pointed to the Out of Order sign stuck to the bathroom door, “—we got locked in here for the game.”
“He’s paranoid,” Grant interjected.
“Well, yeah, maybe,” Brennan retorted. “Or just cautious. Because Sam’s been acting weird lately, and we’re coming up to the last few records of the season, so he’s probably planning something way out of the box for the finale. And the original cast was you, me and Beardsley, so…”
He shrugged one shoulder meaningfully, and Grant nodded, conceding both the point and the potential for chaos.
“So if Sam comes in to give us the briefing, rather than waiting til we’re on set,” Brennan continued, “or there’s anything else weird going on, I’m gonna know about it right from the beginning.”
He turned to the Doctor. “The only reason I'm not quizzing you is because I know for a fact Beardsley was genuinely scheduled for this, so you can't be a plant by the production team. No offence.”
“None taken,” the Doctor smiled. “That sort of thing happen often, does it?”
Grant and Brennan exchanged a look. 
“More than you'd think,” Grant answered with a grimace. 
“Alright,” the Doctor said slowly, then brightened. “So what is it we're actually doing?”
Grant gave him a disbelieving glance. “You don't know—?”
“Very last minute fill-in,” the Doctor said breezily. “But don't worry, I'm a quick study.”
“Well, you're not that much worse off than the rest of us,” Brennan said encouragingly. “You know about Game Changer, obviously, if you know Sam, and we only find out the rules of the game once we get on set. Hopefully,” he added, with a dark look back at the Out of Order sign. 
The Doctor nodded. No, he didn't know Sam, and he didn't know Game Changer, but he could work out the situation from context clues. This was a game show. And with the Toymaker banished, and Satellite Five not coming into existence for another 198000 years, give or take, he found himself smiling. Maybe third time would be the charm. 
“Mmm, hopefully they aren't going to throw you in the deep end,” Grant said. “Because Brennan might seem lovely now, but as soon as we get out there, he's a whore for points. He'll stab you in the back and won't even blink.”
Brennan barked with laughter. “Yeah, and you wouldn't?”
“Excuse you, I'm always a goddamn delight,” Grant replied, the very picture of injured dignity. 
“Oh, absolutely!” agreed a new voice. The Doctor turned to the now-open door to see a bearded man in a pinstriped suit smiling broadly. “That's why we keep inviting you back!”
Grant bowed sarcastically. “Why, thank you, Sam. Good to know I'm appreciated by someone here.”
“Always,” Sam replied, gently but firmly ending that particular path of the conversation. He scanned the room, and his eyes lit up when they landed on the Doctor. 
“Ah, you must be the Doctor!” he said with obvious delight, walking over with his hand outstretched. “I'm Sam—thanks for filling in for us, you've made sure we're going to have a good show. Seriously, it's a pleasure to have you here.”
“Aw, cheers!” the Doctor smiled, shaking the offered hand. “Glad I could help out, I'm really looking forward to this!”
“Well, great!” Sam exclaimed, then took a step back, regarding all three players in turn. “Now, folks, I'm just letting you know that we're just about ready to start the record, so if you can start heading down, that'd be great.”
Grant and Brennan nodded—Brennan, the Doctor noticed, with relief. 
“See you down there,” Sam said, smiling. “Have a great show, and—”
His eyes caught on the Doctor's for a second, twinkling. 
“Good luck.”
---
Backstage, the Doctor, Brennan and Grant were marshalled into podium order and given a final briefing from the crew. And then, with a thumbs-up from Kaylin, that was it.
Showtime.
“Get ready for a Game Changer!” came Sam's voice from onstage. “Tonight’s guests: he can shoot off a monologue with laser accuracy; it’s Brennan Lee Mulligan!”
Brennan, his back to the camera as the curtains opened, spun on his heel and, with a stone-cold expression, pointed finger guns straight down the barrel, before letting the facade crack open. “Hi!” he exclaimed, and walked over to the leftmost podium.
“It’s his first appearance, but he’s already on fire; it’s the Doctor!”
The Doctor leant against the archway to the stage and flashed a broad smile towards the camera, then in a few skipping steps, had bounded over to the next free podium. What the hell, why not make an entrance?
“And even in the toughest of mazes, you’ll always be able to find him; it’s Grant O’Brien!”
Grant dipped his lanky frame into an approximation of a curtsey, spreading his arms wide, then sauntered over to the closest podium with a grin.
“And your host, me!” Sam announced, a ring of manic white showing around his irises as he beamed down the barrel of the camera. “I’ve been here the whole time!”
“This,” he continued, pushing his microphone shut and stowing it in his jacket pocket, “is Game Changer, the only game show where the game changes every show. I am your host, Sam Reich!” 
As he said his name, he looked at his hands, front and back, as if he was pleasantly surprised to be himself, then gestured towards the three podiums.
“I am joined today by these three lovely contestants! Now, you understand how the game works.”
“Of course not,” Grant started. “You know we don't.”
“We can't, Sam, that's the whole point of the theatre you've set up here,” Brennan said over him. 
“Not yet,” was all the Doctor said, anticipation starting to drum a tattoo of excitement against the inside of his ribcage. 
“That’s right!” Sam said brightly, shooting finger guns at the camera. “Our players have no idea what game it is they’re about to play. The only way to learn is by playing. The only way to win is by learning, and the only way to begin is by beginning! So without further ado, let’s begin by giving each of our players fifty points.”
The Doctor, biding his time, watched the reactions of his fellow contestants. Grant looked at the front of his podium, checking the point total, and nodding approvingly when he saw that yes, it was sitting at a round fifty. Brennan, on the other hand, was starting to frown.
“Players, Sam says: touch your nose,” Sam began, and Brennan sighed the sigh of someone who wasn’t happy to be proved right.
“Oh, no,” he groaned. “Oh, you son of a bitch. Wasn’t one this season enough?”
He touched his nose anyway, as did the others, and Sam smiled encouragingly. “Sam says: touch your ear.”
When they all did, Sam nodded. “Touch your other ear.”
Everybody held still, fingers on the ears they had originally touched.
Sam beamed. “Easy, players, right?”
“You say that now,” Brennan said darkly. “Which makes it worse, because all you're doing is setting us up for failure.”
Sam gasped, pretending offence. “Would I do that?”
“Yes,” Brennan and Grant replied in unison, which drew a grin from the Doctor and set Sam off chuckling.
“And I'm not having it,” Brennan continued, leaning his elbows against his podium and pointing at Sam with the hand not touching his ear. “You better watch yourself, because I know how this game works, and you're not going to get one over on me.”
“Strong words, Brennan!” Sam said, clearly delighted by this response. “Okay, then, let's start making things a bit more interesting!”
The game continued as per Sam Says usual, some rounds done as a group and some individual. Points were won, sure, but lost slightly more frequently, and even the Doctor found he was having to concentrate to avoid getting caught in the host's traps. 
It was fun. Genuinely, it was like playing a game with friends, and the Doctor felt himself leaning into it. There wasn't any sign of danger—maybe there wasn't a mystery to solve at all, and the TARDIS just decided he needed a total break. 
Well, probably not. But the way things were going, he was able to let himself hope. 
“Alright, players,” Sam said a good few rounds in, just as pleasantly as he would start any other question, and the screen behind him dinged as a new prompt popped up. “Survive the death beam.”
For a second, everything was frozen perfectly still. 
And then came the crash, the explosive noise of heavy machinery moving relentlessly through a drywall set.
The Doctor was already moving. “Everyone down!”
“Duck!” Brennan yelled at the same time.
The two of them hit the ground within milliseconds of each other, but Grant was still paralysed in the face of the giant, science-fiction type laser cannon that had just ploughed through the wall. 
It whined ominously, screaming its way to fever pitch. And then a sharp pain in Grant’s ankle made him stagger, pitching forwards onto the carpet behind the podiums as the Doctor rolled away to avoid getting pinned.
“Sorry, babes,” the Doctor whispered. “But it was either kick you to get you down, or—”
A hideous metallic screech ripped through the air, and all three of them could feel the crackle of ozone as a beam of energy swept across what had, moments ago, been neck height.
“…Or that,” the Doctor finished with a grimace.
“Jesus fucking Christ,” Grant breathed, suddenly very conscious of every inch of his 6’9 frame. “Thanks.”
“Well done, players!” Sam exclaimed delightedly from above them. “But… sorry, I didn’t say ‘Sam says’, so that’s a point off for everyone.”
“What the fuck!” Brennan snapped.
“Are you actually insane?” Grant demanded at the same time, his voice overlapping with Brennan’s.
In response, Sam just wheezed with laughter. “You can come back to your podiums,” he said, cheerfully ignoring them.
Nobody moved.
“Very good!” he acknowledged, and even without seeing his face, the grin was obvious in his voice. “Okay, Sam says: come back to your podiums.”
Although the words were innocuous, and his tone was just as light and breezy as usual, there was nevertheless an edge hiding just underneath the surface. And while the death beam loomed large in the minds of all three players, it was impossible to consider disobedience as an option.
Slowly, they stood, returning to their places. Now they had the time to look at it properly, the death beam was even more sinister, and Brennan and Grant both kept flicking nervous glances its way, ready to move if it looked like it was charging up again.
The Doctor, however, was focused purely on the man standing in front of them. Unbothered, Sam met his gaze like a challenge, a mischievous smile playing about his lips.
“Oh, you’ll love this one,” he said, and the screen changed. “Sam says, starting with Grant: say my name.”
Grant frowned in confusion, but answered quickly nonetheless. “Sam Reich?”
The man himself shrugged tolerantly, moving on. “Brennan?”
Brennan just stared at him coolly. “Do you take me for a fool?”
“Well caught, Brennan!” Sam said happily. “Sam says: say my name.”
“Sam,” Brennan replied, suspicion clear in his voice. “Samuel Dalton Reich.”
He nodded, still with a hint of indifference. “And lastly, Doctor.” His smile broadened. “Sam says: say my name.”
It was easy. Too easy. And as the Doctor looked into the eyes of the man calling himself Sam Reich, he felt his hearts stutter in recognition, because something had changed. He wasn’t hiding himself anymore, and while the face was different yet again, the Doctor would know the shape of that soul anywhere. It was impossible. It was inevitable.
“You can’t be,” he breathed. 
Sam smirked, leaning in across his podium. “Oh, but Doctor… I’ve been here the whole time,” he stage-whispered with a wink.
“He said you lost,” the Doctor said, shaking his head, looking wrong-footed for the first time that Brennan and Grant could recall. “You lost, and he trapped you.”
The other two watched, uncomprehending, but Sam just smiled, drumming his fingers against the podium with an audible beat, fast but distinct. Four taps, four taps, four taps. “I’m waiting.”
The Doctor took a slow, deep breath. Set his jaw. 
“Master.”
---
missed an installment of the game master cinematic universe?
original idea by @ace-whovian-neuroscientist: x
art by @northernfireart concept: x scissor sisters sketch: x sam and his doppelganger: x
writing by me (!) part one (escape the greenroom): x part two (deja vu): x part three (sam says 4): you are here!
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the-woman-upstairs · 5 months
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Really fucked up that, when they’re young, Patrick and Art are SO tactile with each other, so comfortable sharing the same space. Art lets Patrick touch him and move him and physically overwhelm him and easily acquiesces to it, if not outright enjoys it.
Then in the present, they’ve been so far out of each other’s orbit for so long, held such animosity that when they have their moment alone in the sauna, Art physically recoils from Patrick’s close proximity! It’s so painful to watch because even as Patrick’s goading him, it’s so obvious he wants to be able to get back into Art’s space. But Art has erected all these walls around himself, he refuses to give Patrick an inch or even admit to missing how close they used to be!
AND THEN we see Art and Tashi later and he wants her to hold him, to be gentle with him, and just TOUCH him. Like, he does miss that kind of close physical contact! He either doesn’t know how to ask for it or is uncomfortable being that openly vulnerable. Worth noting that he pretty much always defers to Tashi in regard to initiating physical intimacy (with their first kiss, though he does state his desire, SHE has to be the one to make the first move). And it seems pretty obvious that Tashi herself isn’t comfortable providing that intimacy, whereas Patrick actively seeks to provide it (the hug/forehead kiss after their win together in the early years, dragging the stool closer to him).
Art has tried very hard to act like he doesn’t need physical affection and even though his discipline and devotion to Tashi has made him a stronger tennis player, it’s made him a hollow person, which, in turn, has kept him from becoming a GREAT tennis player.
All of this, of course, is why the ending hits so damn hard.
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curlytsunamiart · 8 months
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murder
(lineart only ver.)
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ohhh hell yes
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morninkim · 6 months
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maybe the kids are alright after all
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galacticturnip-art · 9 months
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Drew the hot gay tiger from Super Lesbian Animal RPG ✨
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