Degradative Effect of Nattokinase on Spike Protein of SARS-CoV-2
Abstract
The coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged as a pandemic and has inflicted enormous damage on the lives of the people and economy of many countries worldwide. However, therapeutic agents against SARS-CoV-2 remain unclear. SARS-CoV-2 has a spike protein (S protein), and cleavage of the S protein is essential for viral entry. Nattokinase is produced by Bacillus subtilis var. natto and is beneficial to human health. In this study, we examined the effect of nattokinase on the S protein of SARS-CoV-2. When cell lysates transfected with S protein were incubated with nattokinase, the S protein was degraded in a dose- and time-dependent manner. Immunofluorescence analysis showed that S protein on the cell surface was degraded when nattokinase was added to the culture medium. Thus, our findings suggest that nattokinase exhibits potential for the inhibition of SARS-CoV-2 infection via S protein degradation.
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anyway in the past week the irish government has voted down two motions which would have condemned the genocide in gaza.
i need everyone to stop lionising ireland as if its not also a european government with strong ties to the us. american weapons pass through shannon airport and will continue to, because yesterday the motion to stop that was voted down 83 to 50.
other governments have done much more but somehow people still act as though ireland is the ultimate palestinian ally and exempt from criticism on its handling of palestine bc it was once colonised, even though that past experience clearly isnt being taken into account by the irish government when creating policy.
i live here i know there’s a lot of public support and sympathy for palestine, which is great, but that isnt reflected in government, and i think ireland should be treated like other countries whose governments have done nothing.
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Why are ppl scared to call it what it is and say we’re still going thru covid on top of seasonal illness. Like. That’s pretty important right. I was watching the news and they were like oh yeah we have an unprecedented number of flu cases “as well as other sicknesses” without actually saying Covid. No announcement abt vaccinations or masking or anything. Also if I hear someone joking abt “war flashbacks” for mentioning covid I fucking hate u
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no matter what happens, no matter how much it hurts, you don't stop dancing, and you don't stop smiling, and you give those people what they want.
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