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CAS NO.620-84-8 4-Methyldiphenylamine Manufacturer/High quality/Best price/In stock
Quick Details Product name:4-Methyldiphenylamine CAS: 620-84-8 Molecular formula:C13H13N EINECS No.:210-655-6 Appearance:white-off solid or colorless liquid Other names：N-Phenyl-p-toluidine;N-PHENYL-P-TOLUIDINE;4-METHYDIPHENYLAMINE;PHENYL-P-TOLYL-AMINE;4-METHYLDIPHENYLAMINE;4-Methyldiphenylamine;4-Methyl-N-phenylaniline;(4-methylphenyl)phenylamine;4-Methyl-N-phenylbenzenamine Port: any port in china Application:OLED intermediates ect. DeliveryTime:As order ProductionCapacity:3 Metric Ton/Month Purity:99%min. LimitNum:100 Gram Packing: according to the clients requirement Storage: Store in dry, dark and ventilated place Transportation: by sea or by air payment methods: L/C, T/T, D/A, D/P, O/A, paypal, western union etc.accept all payment. Application Organic synthesis intermediates, used in the synthesis of organic functional materials and medicine 1. Used as synthetic resin curing agent, additive, fabric finishing agent, etc. 2. Used as a complexing agent, alkaline gas dehydrating agent, dye intermediate, resin solvent and rubber accelerator 3. In addition to being used as a solvent, it is also used in the manufacture of epoxy resin curing agents, rubber additives, emulsifiers, surfactants, lubricating oil additives, fuel oil cleaning and dispersing agents, gas purifiers, cyanide-free plating diffusion agents, brighteners , detergents, softeners, metal chelating agents, and synthetic polyamide resins and ion exchange resins. 4. Complexing agent, cleaning agent, softener, dye synthesis, rubber accelerator, gas dehydration purifier. 5.ethylenediamine tetraacetic acid (EDTA) is an important complex agent. EDTA has a wide range of uses, can be used as bleaching fixing solution for color photographic materials rinsing processing, dyeing AIDS, fiber processing AIDS, cosmetic additives, blood anticoagulants, detergents, stabilizers, synthetic rubber polymerization initiator, EDTA is the representative material of chelating agents. It can form stable water-soluble complexes with alkali metals, rare earth elements and transition metals. In addition to sodium salts, there are ammonium salts, iron, magnesium, calcium, copper, manganese, zinc, cobalt, aluminum and other salts, which have different uses. In addition, EDTA can also be used to detoxify harmful radioactive metals by rapidly excreting them from the body. It is also a water treatment agent. EDTA is also an important indicator, but it is used to titrate metals such as nickel and copper. Only when it is used together with ammonia can the Chemicalbook play the role of indicator. 6.ethylenediamine tetraacetic acid is a kind of excellent calcium and magnesium ion chelating agent, used as water chelating agent for emulsion polymerization, remove Ca2+, Mg2+, Fe2+, Fe3+ and other metal ions. It is also used as a complexing agent of anaerobic adhesive, which is used to treat double methacrylate with EDTA to remove transition metal ions and eliminate the effect of promoting the decomposition of peroxide. The effect of improving the stability of anaerobic adhesive is very good. Sodium EDTA chelating metal ions can improve the speed of modified acrylic acid. Storage stability of solid structure adhesive (SGA), dosage -3×10-4 ~ 6.0×10-4. Dosage 1.5%, 50~C storage stability of more than 360h (50℃ storage for 4d, equivalent to SGA20~C storage for 1 year). 7.Often used for boiler water softening. Prevent scaling. Superiority 1.supply sample 2.the packing can be according the customers` requirment 3.any inquiries will be replied within 24 hours 4.we provide commerical invoice, packing list, bill of loading, coa , health certificate and origin certificate. if your markets have any special requirements, let us know. 5.factory price. 6.prompt delivery. we have good cooperation with many professional forwarders, we can send the products to you once you confirm the order. 7.we can accept various payment methods, l/c, t/t, d/a, d/p, o/a, paypal, western union etc., and we cooperate with sinosure many years. Anyway ,if you need any chemicals from China ,MIT -IVY INDUSTRY CO.,LTD can help you. Company Information MIT-IVY INDUSTRY CO.,LTD is a manufacturer and exporter of fine chemical dyes & pharmaceutical intermediates in China. MIT –IVY Chemicals Industry Co.,Ltd. is a leading manufacturerof chemical for 21 years with complete production equipment and meticulous management and maintenance of machinery. We are an integrated industry and trade company.We use advanced production technology and test methods to realize production, quality controlling to meet the standard. We have been approved by SGS, ISO9001, ISO140 01, GB/HS16949 and T28001. Mit-Ivy main products include as the following： API, pharmaceutical intermediates ,Dye intermediates, fine,speciality chemicals Our main markets includes America, India, Africa, Indonesia, Turkey, South-east Asia, West Asia and so on. MIT-IVY Industry Main products shares 97% of the domestic market specializing in the production and management, We can supply the products with more competitive cost. with premium quality and price and welcome to consult. Our company has professional persons who major in chemical R&D and sicentific management, supply fine chemical products with high quality and close service, also supply custom-tailored products according to our clients’ requirement. We have a positive and self-motivated management work team with a common philosophy, caring and commitment through teamwork, our team strive to achieve success in delighting our clients and ourselves. we continuously innovate our products and improve our service, sales network. Hence, we initiate the first sale mode on net in China, which is the retail trade of small package bring along wholesale of diversified management modes. Our products are exported widely to South Korea, Vietnam, Australia, Europe and South America, highly recommended by our clients. We insist on the management creed “Market is our compass, Quality is our life, Credit is our soul”. Clients’ trust is our forward powder, their satisfaction is our struggling goal. If you are interested in getting more quotations, please add WHATSAPP:0086-13805212761 or E-MAIL:[email protected] FAQ Q1:Will you supply samples for testing? A: For most of our products, samples are available, but please cover the shipping cost. Q2:What's your MOQ? A: For the high value product, our MOQ starts from 10g,100g and 1kg. Q3:Which kind of payment terms do you accept? A: Proforma invoice enclosed with our bank information will be sent after confirmation of order. payment methods: L/C, T/T, D/A, D/P, O/A, paypal, western union etc.accept all payment. Q4:How about your delivery time? A: Generally, it will take 3 to 5 days after receiving your advance payment. Q5:How do you treat quality complaint? A:First of all, our quality control will reduce the quality problem near to zero. If there is a quality problem caused by us, we will send you free goods for replacement or refund your loss. Main products Mit-Ivy is a well-known fine chemicals and pharmaceutical intermediates manufacturer with strong R&D support in China. Mainly involved Aniline, Chlorine products. Payment：DA 60 DAYS TEL:008619961957599 E-MAIL:[email protected] 产品 Product CAS N-甲基间甲苯胺 N-Methyl-M-Methylaniline 696-44-6 N-羟乙基苯胺 N-(2-hydroxyethyl)-Aniline 122-98-5 N-乙基对甲苯胺 N-ethyl-p-toluidine 622-57-1 N,N-二甲基邻甲苯胺 N,N-Dimethyl-o-toluidine 609-72-3 N-甲基邻甲苯胺 N-Methyl-o-methylaniline 611-21-2 N,N-二乙基对甲苯胺 N,N-Diethyl-p-toluidine 613-48-9 N,N-二乙基间甲苯胺 N,N-diethyl-m-toluidine 91-67-8 N-氰乙基－N-羟乙基间甲苯胺 N-cyanoethyl-n-hydroxyethyl-m-toluidine 119-95-9 N-乙基间甲苯胺 N-ethyl-m-toluidine 102-27-2 N-氰乙基－N-羟乙基苯胺 N-cyanoethyl-n-hydroxyethyl aniline 92-64-8 N-乙基邻甲苯胺 N-ethyl-o-toluidine 94-68-8 N,N-二羟乙基对甲苯胺 N,N-dihydroxyethyl-p-toluidine .3077-12-1 N,N-二乙基苯胺 N,N-diethyl aniline 91-66-7 N-丁基－N-羟乙基苯胺 N-butyl-n-hydroxy aniline 3046-94-4 N-乙基－N-氰乙基间甲苯胺 N-ethyl-n-cyanoethyl-m-toluidine 148-69-6 N-丁基－N-氰乙基苯胺 N-butyl-n-cyano aniline 61852-40-2 N-甲基－ N-羟乙基苯胺 N-methyl-n-hydroxyetjyl aniline 93-90-3 N,N-二丁基苯胺 N,N-dibutyl aniline 613-29-6 N-乙基－N-氰乙基苯胺 N-ethyl-n-cyanoethyl aniline 148-87-8 N-正丁基苯胺 N-Phenyl-N-butyl aniline 1126-78-9 N-乙基－N-羟乙基苯胺 N-ethyl-n-hydroxyethyl aniline 92-50-2 N-乙基－N-苄基间甲苯胺 N-ethyl-n-benzyl-m-toluidine 119-94-8 N-甲基－N-苄基苯胺 N-methyl-n-benzyl aniline 614-30-2 N-异丙基苯胺 N-isopropy aniline 768-52-5 N-乙基－N-苄基苯胺 N-ethyl-n-benzyl aniline 92-59-1 N-环已基苯胺 N-Cyclohexylaniline 1821-36-9 N,N-二甲基间甲苯胺 N,N,3-trimethyl- Dimethyl-m-toluidine 121-72-2 N-甲基甲酰苯胺 N-Methylformanilide 93-61-8 N-甲基-N-羟乙基对甲苯胺 N-(2-HYDROXYETHYL)-N-METHYL-4-TOLUIDINE 2842-44-6 N,N-二甲基对甲苯胺 N,N,4-trimethyl-;dimethyl-4-toluidine; Dimethyl-p-toluidine 99-97-8 N-甲基对甲苯胺 N-Methyl-p-toluidine 623-08-5 N,N-二甲基苯胺 N,N-dimethyl aniline 121-69-7 N,N-二羟乙基苯胺 N,N-dihydroxyethyl aniline 120-07-0 N-乙基-N-羟乙基间甲苯胺 N-Ethyl-N-Hydroxyethyl-M-Toluidine 91-88-3 N,N-二羟乙基间甲苯胺 N,N-dihydroxyethyl-m-toluidine 91-99-6 N-乙基苯胺 N-ethyl aniline 103-69-5 N-甲基苯胺 N-methyl aniline 100-61-8 N-甲基对甲苯胺 4-Methyl-N-methylaniline 623-08-5 N-甲基-N-羟乙基苯胺 2-(N-Methylanilino)ethanol 93-90-3 N,N-二甲基对苯二胺 N,N-DIMETHYL-P-PHENYLENEDIAMINE 99-98-9 3-(甲氨基)甲苯 3-(Methylamino)toluene 696-44-6 N,N-二异丙醇对甲苯胺 DIPROPOXY-P-TOLUIDINE 38668-48-3 N,N-二乙基邻甲苯胺 N,N-DIETHYL-O-TOLUIDINE 606-46-2 N-甲基对硝基苯胺 N-Methyl-4-nitroaniline 100-15-2 N,N-二苄基苯胺 N,N-DIBENZYLANILINE 91-73-6 N-苯基乙醇胺 2-Anilinoethanol 122-98-5 N-苄基苯胺 N-Phenylbenzylamine 103-32-2 N-羟乙基间甲苯胺 N-2-HYDROXYETHYL-M-TOLUIDINE 102-41-0 N-乙基N氯乙基间甲苯胺 N-ETHYL-N-CHLOROETHYL-M-TOLUIDINE 22564-43-8 N,N-二乙基-4-氨基-2-甲基苯甲醛 4-Diethylamino-2-methylbenzaldehyde 92-14-8 间甲苯胺 M-Toluidine MT 108-44-1 1,4-二溴-2,5-二碘苯 1,4-DIBROMO-2,5-DIIODOBENZENE 63262-06-6 N,N-二羟乙基对苯二胺硫酸盐 N,N-Bis(2-hydroxyethyl)-p-phenylenediamine sulphate 54381-16-7 N-乙基-N-苄基-4-氨基苯甲醛 4-(N-Ethyl-N-benzyl)amino-benzoaldehyde 67676-47-5 N,N-二乙基-4-氨基苯甲醛 4-Diethylaminobenzaldehyde 120-21-8 对二甲胺基苯甲醛 p-Dimethylaminobenzaldehyde 100-10-7 2-氨基噻唑 2-Aminothiazole 96-50-4 对甲苯胺 P-Toluidine PT 106-49-0 N,N-双(2-羟基丙基)苯胺 N,N-BIS(2-HYDROXYPROPYL)ANILINE 3077-13-2 N-乙基-N-氰乙基苯胺 3-Ethylanilinopropiononitrile 148-87-8 N-乙基-N-(3'-磺酸苄基)苯胺 N-Ethyl-N-benzylaniline-3'-sulfonic acid 101-11-1 邻苯甲酰苯甲酸甲酯 Methyl 2-benzoylbenzoate 606-28-0 对羟基苯甲酸甲酯 Methylparaben 99-76-3 十四酸异丙酯 Isopropyl myristate 110-27-0 棕榈酸异丙酯 Isopropyl palmitate 142-91-6 邻甲苯胺 O-Toluidine OT 95-53-4 4-甲基-N-苯基苯胺 N-PHENYL-P-TOLUIDINE 620-84-8 N,N-二甲基苄胺 N,N-Dimethylbenzylamine BDMA 103-83-3 N,N-二甲基甲酰胺 N,N-Dimethylformamide DMF .68-12-2 N-甲基甲酰胺 N,N-Dimethylformamidedimethyl acetal (DMF-DMA) 4637-24-5 N,N-二甲基乙酰胺 N,N-Dimethylacetamide DMAC 127-19-5 N,N-二乙基间甲苯甲酰胺 避蚊胺 N,N-diethyl-m-toluamide DEET 134-62-3 N,N-二乙基羟胺 N,N-Diethylhydroxylamine DEHA 3710-84-7 N,N-二甲基-间甲基苯胺 N,N-DIMETHYL-M-TOLUIDINE 121-72-2 N-甲基二苯胺 N-Methyldiphenylamine 552-82-9 N,N-二氰乙基苯胺 N,N-Dicyanoethylaniline 1555-66-4 N-乙基-2-硝基苯胺 N-Ethyl-2-Nitro-Benzenamine 10112-15-9 N-(2-羟乙基)乙二胺 AEEA 111-41-1 二乙���三胺(DETA) Diethylenetriamine DETA 111-40-0 三乙烯二胺 Triethylenediamine 280-57-9 三乙烯四胺 TriethylenetetramineTETA 112-24-3 四乙烯五胺 TEPA 112-57-2 间二氯苯 1,3-Dichlorobenzene MDCB 541-73-1 间二三氟甲苯 1,3-Bis(trifluoromethyl)-benzene 402-31-3 粉末丁腈橡胶 MITIVY33-1（POLYMER/ADHESIVE COMPOUNDING） 9003-18-3 十六烷基氯化吡��� Cetylpyridinium chloride monohydrate 6004-24-6 对氯甲苯 4-Chlorotoluene 106-43-4 无水硫酸钠 SODIUM SULFATE 7757-82-6 /15124-09-1 碱性嫩黄 Auramine O 2465-27-2 偶氮二异丁腈 2,2'-Azobis(2-methylpropionitrile) 78-67-1 Read the full article
#(4-methylphenyl)phenylamine#4-METHYDIPHENYLAMINE#4-Methyl-N-phenylaniline#4-Methyl-N-phenylbenzenamine#4-Methyldiphenylamine#4-Methyldiphenylamine620-84-8#620-84-8#Amines#Aniline#API#aromaticamines#BuyHighqualityof4-Methyldiphenylamine#C13H13N#CASNO.620-84-8#chemicalrawmaterials#Dyeintermediates#Finechemicals#Generalreagents#Hotsale4-Methyldiphenylamine#intermediates#N-PHENYL-P-TOLUIDINE#NitrogenCompounds#OrganicBuildingBlocks#organicchemicalrawmaterials#organicchemistry#organicintermediates#pharmaceuticalintermediates#Pharmaceuticalrawmaterials#PHENYL-P-TOLYL-AMINE#polyesterresin
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I posted 3,874 times in 2022
620 posts created (16%)
3,254 posts reblogged (84%)
Blogs I reblogged the most:
@rogueninja
@sasukeless
@sasukelandia
@sasukeheart
I tagged 3,643 of my posts in 2022
Only 6% of my posts had no tags
#sns - 1,150 posts
#p - 387 posts
#sasuke - 271 posts
#uzumaki naruto - 225 posts
#team 7 - 108 posts
#sleepy - 95 posts
#q - 93 posts
#kiss kiss fall in love - 80 posts
#asks - 73 posts
#chats - 72 posts
Longest Tag: 139 characters
#also the combination of horror and comedy written side by side like that sounds... 🛑🤲📿🙏 let me say some protection prayers from you jks
My Top Posts in 2022:
#5
broke : sakura is the glue that holds naruto and sasuke from self-combusting
woke : sasuke is the glue that naruto and sakura both bond over as team 7
bespoke : there is no glue between the 3. team 7 is naruto&sasuke .. and sakura
- Posted January 31, 2022
#4
Cinematic parallels
Will Smith (Oscars, 2022) / Naruto (1999-2014)
- Posted April 6, 2022
#3
naruto&sasuke isn't something i ship. it's something i understand.
- Posted August 25, 2022
#2
sasuke's "I love you and that makes me weak" vs naruto's "I love you and that makes me strong"
- Posted January 24, 2022
My #1 post of 2022
i literally cant believe naruto got through to sasuke by for all intents and purposes saying 'i feel the same way' like a mutual love confession and sasuke cried and was so vulnerable he looked away and naruto say him and was shocked but then laughed like these fools are on their deathbeds confessing their shared emotions and thats how this series about child soldiers sentenced to a life of war and hatred were able to start healing from that by loving each other on purpose
- Posted January 8, 2022
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I posted 967 times in 2022
152 posts created (16%)
815 posts reblogged (84%)
Blogs I reblogged the most:
@lumii-is-the-name
@eventidecryptid
@mudzdale
@chameshida
@baisleyarts
I tagged 967 of my posts in 2022
#reblog - 804 posts
#art - 623 posts
#httyd - 620 posts
#httyd fanart - 490 posts
#night fury - 339 posts
#toothless - 261 posts
#hiccup - 142 posts
#httyd oc - 137 posts
#night light - 94 posts
#light fury - 90 posts
Longest Tag: 138 characters
#this completely goes against the themes of the franchise (at least if ur actually like. killing them) but it could certainly be a fun game
My Top Posts in 2022:
#5
youtube
They're introducing a species from Rescue Riders into the main universe/canon and they somehow look so much worse than they did in Rescue Riders 😭😭😭😭😭
like theyre SO fucking ugly who did this dreamworks why did you choose THIS species to bring over out of all the rescue riders dragons i dont understand
62 notes - Posted April 30, 2022
#4
Wanted to make a new chunky baby fury oc and got a bit carried away - I imagine he's one of Toothless and Chunkful's babbies in my au LOL
84 notes - Posted January 8, 2022
#3
Hello friend! I am looking for what I'm positive is some older Nico Marlet concept art of a Night Fury hatchling... Google is bringing me nothing but I'm fairly sure you've posted about them before. Do you happen to know what I'm talking about? 😅
Soooo sorry for the super late response but if you're still looking, here it is! I managed to find this screencap compilation made by someone which features it on the bottom left. I tried to find a full high quality version of just the page with the Night Fury hatchling art but man it's hard to find good Riders of Berk screencaps:
Cropped/close up (pretty bad quality, sorry!):
See the full post
86 notes - Posted November 16, 2022
#2
why is one of the writers for tnr saying weird shit like this like this didn't answer that person's question what are you going on about
88 notes - Posted September 24, 2022
My #1 post of 2022
Wait, the Boneknapper isn’t canon anymore? Since when?
Yep, a couple years ago Richard Hamilton straight up said it wasn't "officially canon" on Twitter.
See the full post
93 notes - Posted October 2, 2022
Get your Tumblr 2022 Year in Review →
#tumblr2022#year in review#my 2022 tumblr year in review#your tumblr year in review#long post#Youtube
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Alliance hero concept: Vithor, the berserker... this is probably overpowered
Overview: A mad dwarf filled with battle-rage who has sworn an oath to Linirea; Vithor Firebeard is quite proficient in the art of slicing enemies with his very sharp ax. Versatile and unrelenting, this angry dwarf is here to slay!
HP (starting at LvL 5): 500/528/564/590/620/650. Respawn rate: 35 seconds
Armor: 10%/10%/15%/15%/20%/20%. damage: 10-30/13-32/15-35/17-38/19-39/21-40. attack rate: 2s
Abilities;
Dwarfweiser©️®️™️ (active), costs are 2/3/1: Vithor swigs down a 'potion' recovering 10/15/20 hp per second over a span of 3/5/7 sec.
Barrel of F.U.N. (active), costs are 3/3/2: He throws an explosive keg that deals 64-104/84-164/104-222 area damage... if he's engaged in melee with an enemy, he'll detente over their head dealing 1/4 damage to himself. (Cooldown: 30 seconds)
Titanic Twister (active), costs are 2/2/3: Vithor spins dealing 25-45/30-50/36-56 physical damage in an AoE around him. This has a cooldown of 33 sec (with 3 of the sec spent with him being stunned)
Inspire Courage (active), costs 3/3/4: empowers nearby allies for 4 seconds (cool down is 42 sec); this power-up includes a damage boost of +2/+4/+6, an armor boost of +5%/+10%/+15%, and a heal-rate boost of +15% max HP! Requires 2 nearby allies to activate.
Wrath of the Slayer (Hero Spell), costs 3/4/2: When cast Vithor's damage doubles, his heal-rate increases by 15% of his max hp, his armor doubles, and his attack rate halves; this state lasts for 4/6/8 sec
Quotes;
"LET ME SOLO THEM!!"
"WHO SENDS BABIES TO FIGHT?!"
"I STILL COUNT AS ONE!!"
"FIREBEARDS FIGHT ON!!"
"Not the beard!" <- upon death
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Progress in the Study of the Photosensitizing Effect of Spirulina Phycocyanin
Abstract: Spirulina is a widely cultivated filamentous cyanobacterium. The phycocyanin extracted from Spirulina has a variety of biological functions such as anti-tumor and immune enhancement, and as a photosensitizer, phycocyanin can be applied to tumor therapy. This paper describes the structure of phycocyanin, the principle of photodynamic therapy and the research progress of phycocyanin photosensitization, and introduces the current situation and prospect of the application of phycocyanin in photodynamic therapy.
Spirulina is a filamentous multicellular spiral-shaped prokaryotic algae belonging to the family of Cyanobacteria, Candida. It has a history of 3.5 billion years on earth and is one of the oldest existing plants. It is characterized by high protein content and rapid reproduction, and has been widely cultivated all over the world, especially in our country, with abundant sources. The high content of phycocyanin (PC) in Spirulina is an important natural pigment for photosynthesis in the cells of Spirulina, and it can preferentially transfer light energy to photosystem II with nearly 100% efficiency in photosynthesis. PC can improve human immunity, promote the regeneration of animal blood cells and inhibit certain cancer cells. At the same time, PC is an ideal photosensitizer without toxic side effects [1, 2].
Photodynamic therapy (PDT) is to realize the therapeutic purpose through the biological effects induced by the combination of photosensitizers, light and molecular oxygen in the focal area, which involves a wide range of clinical applications, including the diagnosis and treatment of tumors and many other non-oncological diseases, such as atherosclerosis, rheumatoid arthritis, etc.[4] . It has a wide range of clinical applications, including the diagnosis and treatment of tumors and many other non-tumor diseases, such as atherosclerosis, rheumatoid arthritis, etc.[4] The core issue of PDT is the photosensitizing agent, which is non-toxic, a good nutrient, and has a fast metabolism in the body, and thus can be a new type of photosensitizing agent.
1 Structural and physicochemical properties of algal blue protein
The relative molecular mass of PC is generally around 30 k. It consists of two equimolar α and β subunits of different relative molecular masses, both of which have a relative molecular mass of around 15 k. Under natural conditions, the two subunits usually form (αβ)3 or (αβ)6 polymers [4,5]. Each subunit consists of an apoprotein and an open-chain tetrapyrrole chromophore, which is crosslinked to the cysteine residue of the apoprotein via a thioether bond. pc contains only one chromophore, phycocyanobilin (PCB). pcB is a cholestrellene compound, which has two major peaks of absorption, one in the ultraviolet (UV) region and one in the visible region. One is in the UV region and the other is in the visible region. The natural PC is covalently bound to PCB at positions α-84, β- 84, and β- 155[5-7] . The photosensitive properties of PC may be related to the molecular structure of PC, which is similar to that of porphyrin in its open-chain tetrapyrrole structure shown in Fig. 1[8] .
The isolated and purified water-soluble PCs showed blue color in solution and developed purple fluorescence. Yin Gang et al.[9] showed that the UV-Vis spectrum of Spirulina blunt-topped algal cyanobacteria had characteristic absorption peaks at wavelengths of 278 nm, 360 nm and 620 nm. Peng Weimin et al.[10] measured the maximum visible absorption peak of Spirulina obtususifera at 620 nm by UV-visible spectrophotometer, and the fluorescence emission peak was measured at 645 at room temperature by fluorescence spectrophotometer.
2 Photodynamic therapy
2.1 The principle of photodynamic action The basis of photodynamic therapy is biological photodynamic sensitization. After the organism accepts photosensitizer for a certain period of time, the tumor tissue takes in and retains more photosensitizer, and when irradiated by light of specific wavelength, the photosensitizer absorbs light and transfers the absorbed light energy to the surrounding oxygen molecules to make it become reactive oxygen species (ROS), destroying many kinds of biomolecules in the tissues and cells, and ultimately causing the death of the tumor cells to achieve the therapeutic purpose. to achieve the therapeutic purpose.
The mechanism of ROS generation is: when there is no light, the photosensitizer molecule is in the ground state S 0, the ground state photosensitizer absorbs the energy of photon, and then it jumps to the triple state T through the single state S 1 (the life time is very short, only 10-9 to 10-6 seconds), and the triple state sensitizer which is stimulated by the light can carry out the following two forms of reaction[11,12]: the first form is to react with the substrate or solvent directly through the transfer of the hydrogen atoms or electrons, forming radicals or radical ions, and the latter can produce oxidation products with oxygen, and this type of reaction is called Type I reaction. The first form is through the transfer of hydrogen atoms or electrons, directly reacting with the substrate or solvent to form free radicals or radical ions, which can produce oxidation products with oxygen, and this type of reaction is called Type I reaction; the second form is to transfer the energy to molecular oxygen to form a single linear state of oxygen (1O2), which is a highly active oxidant and can cause the substrate to be oxidized, and this type of reaction is called Type Ⅱ reaction. Sometimes there is an electron transfer from the sensitizer to the oxygen, giving the oxidized sensitizer and O2- -, a process that belongs to a Type II reaction, which was often defined as a Type I reaction in the past. This process is a type II reaction, often defined as a type I reaction in the past. Type I and type II reactions can occur simultaneously, and the ratio of the two is affected by the sensitizer, the substrate, the oxygen concentration, and the degree of binding of the sensitizer to the substrate. The photosensitization reaction is illustrated in Figure 2.
Fig. 2 Schematic representation of photosensitized type I and type II reactions [12]
The mechanism of action of PDT in the treatment of tumors is very complicated, and there are three main mechanisms of action in general [13,14]: firstly, the ROS generated by PDT, especially monolinear oxygen, can directly kill tumor cells (induce cell apoptosis or necrosis); secondly, PDT can activate the body's anti-tumor immune response; and thirdly, PDT can also damage the vascular system associated with tumors and destroy microvessels within the tumor, resulting in ischemic death of the tumor cells. Third, PDT can also damage the vascular system associated with the tumor, destroying the microvessels within the tumor and causing ischemic death of tumor cells due to hypoxia. Tumor cell death is the result of a combination of effects. All of these mechanisms are necessary for long-term tumor control and treatment.
Compared with traditional chemotherapy, surgery and radiation therapy, PDT has the following advantages [11 , 15]: relatively non-invasive treatment, can accurately locate the target tumor tissue, more thorough and painless treatment; synergistic, low recurrence rate, and can achieve the goal of eradicating most of the early-stage cancers; no limit on the total dose of the drug can be given repeatedly; the whole process of treatment does not cause, or brings very little scarring; relatively easy to operate and has few side effects. The whole treatment process will not or only bring small scars; the operation is relatively convenient and the side effects are small, etc. In the past 20 years, the research of PDT therapy for cancer treatment has made remarkable achievements [14], but the current problem to be solved is to find a photosensitizer with high affinity for tumor tissue, convenient administration, and low toxicity and side effects on the skin.
2.2 Photosensitizers
Photodynamic therapy has been introduced, developed, and refined with the development of related photosensitizers. Commonly used photosensitizers in this field are porphyrin-like molecules with a tetrapyrrole structure that absorb and re-emit light at specific wavelengths. Photosensitizers are selectively enriched in specific tissues and can produce a photodynamic effect that destroys target cells when excited by ultraviolet or visible light.
Ideal photosensitizers must meet the following conditions[16,17]: (1) they have a stronger affinity for tumor cells than normal cells, and thus are mainly enriched at the focal site; (2) they can efficiently generate free radicals or reactive oxygen species after absorbing light, thus killing tumor cells; (3) they can be rapidly cleared from normal tissues, with little or no toxic side effects; (4) they can maximize penetration into deeper layers of tissues in the required wavelength range; and (5) they have high purity. (4) the desired wavelength range of light can maximize the penetration of the tissue to the deep layer; (5) high purity.
Currently, the clinical application of hemocyanin derivatives can only be used for superficial tumors, with limited selectivity for tumor targets and serious photosensitivity side effects due to slow metabolism. In 1989, the U.S. Patent introduced the application of C-PC as a photosensitizer for the treatment of atherosclerosis in in vitro experiments and animal experiments on transplanted tumors, and it was reported that C-PC had a significant effect on removing sclerotic plaques in blood vessels, and had a significant killing effect on transplanted cancer cells. It was reported that C-PC had a significant removal effect on sclerotic plaques in blood vessels and a significant killing effect on transplanted cancer cells. The formation of O2- and - OH in oxygen-saturated aqueous solution of CP was clearly observed by ESR-spin trapping using DMPO as a spin trapping agent [18,19]. PC is less photosensitized to sunlight and causes less skin phototoxicity. It is also strongly absorbed at therapeutic wavelengths, while it is weakly absorbed or not absorbed at other wavelengths. Experiments have proved that it has a strong effect on killing tumor cells by photosensitivity. Therefore, it is more suitable to be developed into a new type of photosensitive drug for tumor photodynamic therapy.
3 Photosensitization of alginate
3.1 Experimental study of PC photosensitization
As early as 1988, Morcos[20] treated mouse bone marrow cultured cells with 0.25 mg/mL PC, and found that the cell survival rate was only 15% after 514 nm laser irradiation of 300 J/cm2 , while the cell survival rate of laser irradiation or PC treatment alone was 69% or 71%.
In 1995, Cai Xinhan et al.[21] treated colorectal cancer cell line HR-8348 with PC1640 culture solution at concentrations of 100 μg/mL, 50 μg/mL and 25 μg/mL, respectively, and irradiated the cells with pulsed copper laser at a wavelength of 630 nm. The cell survival rates were 22.1%, 37.6% and 89.7% as measured by MTT method after 24 h of incubation, and the P values of different concentrations were <0.001, with a good linear relationship. This proves that PC does have photosensitizing effect. In 1995, Cai Xinhan et al.[2 2] used S18 0 transplanted mice, injected with PC (2 mg) and orally (20 mg), and then irradiated the tumor with copper laser for 15 d. The effective rates were 50% and 53%, respectively, which were significantly different from those of the control groups of laser/no PC and no PC, while there was no difference between the injected and orally irradiated groups. Comparison of tumor weight before and after irradiation showed that the growth rate of the tumor was significantly slowed down compared with that of the blank control group.
3.2 Experimental study of the photosensitizing effect of PC pigment peptides
Huang Bei et al. [23] isolated three kinds of pigment peptides from Spiroplasma by extracting PCs with trypsin, and detected the effects of pigment peptides on the in vitro cultured mouse sarcoma cells S180 and the PDT of tumor-bearing mice by MTT and acridine orange staining: (1) The results of the effect on the survival rate of S180 cells: the three fragments of pigment peptides CCP1-CCP3 had better PDT effects, which were stronger than the C-PC aggregated state on the tumor cell killing. The effect of PDT on the survival rate of S180 cells is as follows: all three fragments of CCP1 - CCP3 have better effect of PDT, which is significantly stronger than the killing effect of C-PC aggregation on tumor cells.
From the comparison between CCP1-CCP3 digested fragments, it seems that the killing effect of PDT of CCP1 and CCP3 is dominant: at a concentration of 100 μg/mL, the effect on the survival rate of S180 cells is 19.8% - 23%, while CCP2 is weaker; at a concentration of 100 μg/mL, the effect on the survival rate of tumor cells is 54.6%. In terms of direct cell damage, CCP3 was the most potent, with a killing effect on S180 cells of 41%-31.8% at a concentration range of 25-100 μg/mL, while that of CCP1 was only 98.2%-60.8% at the same concentration range. (2) Inhibition of transplanted tumors: At the irradiation dose of 120J/cm2 , the injection volume of photosensitizer next to the tumor was 50μg/tumor, and the tumor size was in the range of 0.5-0.7cm, the tumor inhibition rates of CCP1 and CCP3 were 46% and 81%, respectively, at 7d after irradiation. CCP3 had the strongest killing effect because of its small molecular weight PCB pigment peptide, and the tumor inhibition rate of CCP1 was less than 50%.
3.3 Comparative experiments on the photosensitizing properties of PC and other algal bile proteins
Li Guanwu et al. [24] compared the phototoxicity of three algal bile proteins, phycocephalin (PE), PC and allophycocyanin (APC), with that of hematoporphyrin derivatives. The cell-killing ability of each photosensitizer molecule was positively correlated with the total light absorption of each photosensitizer under irradiation with a tungsten iodine lamp and sunlight. The differences between the photosensitizers hematoporphyrin derivatives (HPD), Photofrin II, and phaeophytin were not as large as theoretically possible, but the experiments basically showed that the phototoxicity of phaeophytin was much less than that of HPD and Photofrin II. The results and theoretical analyses demonstrated that PE was more photosensitized to sunlight than the other two phycobilins, but much less so than the hematoporphyrin derivatives. Among the three phycobilins, APC was the least solar phototoxic. In addition, the experimental results were much less different than those obtained from theoretical analyses, which may be related to the respective microenvironments in solution, including unidentified factors such as solubility in oxygen, the degree of aggregation of photosensitizer molecules, and the nature of the heat generated by the light.
4 Outlook
Since the mid-1970s, Mexico, the United States, Japan, Israel and China have successively established spirulina production plants. According to statistics, the annual production of spirulina in the world was 1,000t in 1983, but it doubled to about 2,000t in 1994, and the production has gradually increased in recent years. Spirulina is extremely rich in nutrients and is recommended by FAO as "the most ideal food for mankind tomorrow". Its protein content is as high as 50%-70%, which is an excellent protein source, and the content of PC can reach 25%-28% of the dry weight of the cells. - PC is an important active substance in Spirulina, and studies at home and abroad have shown that Spirulina and its active ingredients have a broad application prospect in the research and development of functional foods and drugs [25]. The use of PC as a photosensitizer for tumor photodynamic therapy is abundant and inexpensive. Therefore, the use of PC as a photosensitizer in photodynamic therapy will show good application prospects.
[References]
[1] Zeng Fanjie, Lin Qishan, Zhu Liping. Separation and characterization of R-alginin from the red alga Brassica napus. Journal of Biochemistry and Biophysics, 1992, 24(6): 545-55
[2] Glazer AN. A macromolecular complex optimized for light energy transfer. Biochim Biophys Acta, 1984, 768:29-51
[3] Tian Yuanyuan. Application of photodynamic therapy in the treatment of tumors. International Academic News, 2005, 1: 19
[4] YI Guo-Liang, JIANG Li-Jin. Modeling reactions for the biosynthesis of cyanobacterial proteins. Journal of Chemistry, 1991, (49): 94-7
[5] WANG Guangze, DANG Tian, ZENG Chengkui. An overview of algal bile proteins (Ⅰ) - Types and composition of algal bile proteins. Marine Science, 2000, 24(2): 22-5.
[6] Wang Guangze, Deng Tian, Zeng Chengkui. Research on algal bile proteins (II) - Structure and spectral properties of algal bile proteins. Marine Science, 2000, 24(3): 19-21
[7] AnilK, Padyana S. Ramakumar.Lateral energy transfer model for adjacent light-harvesting antennae rods of C-phycocyanins.Biochim Biophys Acta,. 2006, 1757: 161-5
[8] Zhang WX, Liang H, Qin HC, et al. Extraction of phycocyanin from Spirulina. Fine Chemical Industry, 1999, 6: 40-2
[9] Yin G, Li F, He Q, et al. Separation and purification of algal bile proteins and polysaccharides from Spirulina and product characterization. Fine Chemistry, 1999, 2: 10-3.
[10] PENG Wei-min, SHANG Shu-tian, FU You-lan, et al. Studies on the properties of bile proteins in Spirulina obtususus. Journal of China Agricultural University, 1999, 4(Suppl.): 35-8.
[11] Ackroyd R, Kelty C, Brown N, et.al. The history of photodetection and photodynamic therapy.Photochem Photobiol, 2001, 74: 656-69
[12] Foote CS. Definition of type Ⅰ and type Ⅱ photosensiti-zeoxidation. Photochem Photobiol, 1991, 54: 659
[13] ZHANG Shen-Feng, GONG Xing-Guo. Mechanism of photodynamic therapy on tumors and its effects. Journal of Cell Biology, 2005, 27: 395-9
[14] Zhai Y, Han GF. Progress of photosensitizers for cancer treatment by photodynamic therapy. Chinese Journal of Laser Medicine, 2006, 1: 48-55
[15] Nyman ES, Hynninen PH. Research advances in the use of tetrapyrrolic photosensitizers for photodynamic therapy. Photochem Photobiol B: Biology , 2004, 73: 1-28
[16] Anstey A. Photodynamic therapy. Medicine, 2004, 12(32): 24-5
[17] Ji Zhenyu, Yu Lina, Yang Guanrui, et al. Mechanisms of tumor photodynamic therapy. World Journal of Chinese Gastroenterology, 2005, 13(15): 1879-84.
[18] He JA, Hu YZ, Jiang LJ . Photodynamic action of phycobiliproteins: in situ generation of reactive oxygen species. Biochim Biophys Acta, 1997, 1230: 165-74
[19] Zhang SP, Xie J, Zhang JP, et.al. Electron spin resonance studies on photosensitized formation of hydroxylradical by C-phycocyanin from Spirulina platensis. Biochim Biophys Acta, 1999, 1426: 205-11
[20] Morcos NC. Phycocyanin: laseractivation, cytotoxic effects, and uptake in human atherosclerotic plaque.LaserSurgMed, 1988, 8(1): 10-7
[21] Cai, X. Han, He, L. M., Zheng, S., et al. Killing effect of Phycocyanin-Cu laser on colorectal cancer cell line HR-8348. Tumor Control Research, 1995, 22(1): 19-21
[22] Cai, X. Han, Zheng, S., He, L. M., et al. Research on the use of phycocyanin in laser cancer treatment. Chinese Journal of Experimental Surgery, 1995, 12(5): 290-1
[23] Huang Bei, Wang Guangze, Li Zhengang. Experimental study on the photodynamic anti-tumor effects of phycocyanin pigment peptides. Journal of Laser Biology, 2002, 11(3): 194-8
[24] Li Guanwu, Wu Jianyi, Chen Aiyun, et al. Comparison of phototoxicity between alginin and porphyrin derivative photosensitizers. Comparison of phototoxicity between algal bile proteins and porphyrin-derived photosensitizers. Shantou University Medical Journal, 2005, 18(4): 193-9
[25] Hao Wei, Pan Ling. Advances in the physiological activity of cyanobacterial proteins from Spirulina. Medical Review, 2006, 12(2): 111-3
#phycocyanin #phycocyaninpowder #spirulina #phycocyaninspirulina
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New and used car buyers often want to know - what are the average 2023 car loan interest rates and APRs they can expect to see? Interest rates impact the monthly payment and total loan cost. This guide examines current auto loan APRs, factors that influence rates, and how to secure the best financing in 2023. What is APR? What is the Current Average New Car Loan APR in 2023? For new cars in 2023, average APRs by credit score are: 800+ credit score (prime) - 3% to 5% APR 700-799 credit score (prime) - 4% to 6% APR 620-699 credit score (non-prime) - 6% to 10% APR 600-619 credit score (subprime) - 10% to 14% APR Under 600 credit score (deep subprime) - 14% to 20% APR Shop prime lenders to access interest rates below 5% for new cars based on a strong 700+ credit score. Those under 640 may pay double digit rates from subprime lenders. What is the Current Average Used Car Loan APR in 2023? For used car purchases in 2023, average APRs are: 800+ credit score (prime) - 4% to 7% APR 700-799 credit score (prime) - 5% to 8% APR 620-699 credit score (non-prime) - 8% to 12% APR 600-619 credit score (subprime) - 12% to 16% APR Under 600 credit score (deep subprime) - 16% to 24% APR Used car interest rates run 1-2% higher than new currently. Strong credit still nets rates under 8% from prime lenders. Subprime buyers pay significantly more. How to Secure a Good APR for a Car Loan Prime Car Loan Rates vs Subprime Rates in 2023 Prime borrowers (700+ credit) generally see: New car rates from 3% to 7% APR Used car rates from 4% to 8% APR Subprime borrowers (under 640 credit) generally see: New car rates from 8% to 20% APR Used car rates from 10% to 24% APR Having prime credit saves thousands over the auto loan term by qualifying better rates. Subprime terms carry expensive risk premiums. How Does Credit Score Impact Auto Loan Interest Rates? Credit score influence on APR: 800+ scores offer the lowest rates due to representing ultra prime borrowers. 700-749 scores see minor impacts, with rates 1% higher than 800+. 640-699 scores classify as non-prime with rates 2-4% above prime. Under 640 are subprime with significant rate increases. Scores below 600 see drastic jumps. Improving credit from good to excellent can save 1% or more, while falling from prime to subprime can double rates. Average Auto Loan Term Lengths Typical loan terms and impact on APR: 36 months - Lower rates but higher monthly payment. 48 months - Allows lower payment with slight rate increase. 60 months - Average term length with moderate rates. 72 months - Lowest payment but higher rates from risk. 84 months - Riskiest term with highest rates but lowest payment. Aim for 60 months or less to keep rates down. Budget appropriately to avoid very long terms unless necessary. Understanding Car Loan Terms Do Auto Loan Rates Vary by State? 2023 auto loan rates don’t vary significantly by state, but factors in specific locations can have some influence: State maximum interest rate caps on loans impact rate ceilings. But most are above 15%. Regional economic factors like unemployment may account for small variations. Credit score distributions and financial trends in local areas move rates. Promotions and incentives from lenders in a given state can create minor variances. But any state-level differences amount to less than 1% typically. National lender rates are broadly similar. Down Payment Percentage Effect on Interest Rates Typical down payment tiers and impact on APR: 0-4% down - Highest rates; risky for lender 5-9% down - Slight rate improvement 10-19% down - Lower rates in prime territory 20%+ down - Maximum rate incentive; best terms Larger down payments signal lessened risk and commitment from borrowers. This earns lower interest rates from lenders. How Auto Loan Rates Have Changed 2022 average new car rate - 5.2% APR
2021 average new car rate - 4.1% APR Rates rose over 1% due to: Federal interest rate hikes High inflation Tighter lending restrictions Supply chain constraints Expect rates above 5% for the near term until inflation cools in 2023-2024. Pre-Approval for Lower Rates Getting pre-approved for financing helps: Lock in current rates before future hikes Compare multiple lender rates Focus searches only on approved loan amount Negotiate from a position of strength at the dealership Don’t wait - secure favorable rates now before further increases. FAQs How much does auto loan interest vary from month to month? Very little variance monthly. Market-wide shifts lead to adjustments every few months in 0.25 to 0.5% increments based on macro factors. Which lenders offer the lowest interest rates right now? Online lenders, credit unions, and community banks often offer the most competitive rates versus large national banks. How much does the length of the loan change interest rates? Going from a 60 month term up to 72 or 84 months can increase rates around 0.5% typically. What’s better - longer term with lower payment or higher rate? Go for the shortest term you can afford the monthly payment on. Lower rates save thousands over the life of the loan. How much can improving my credit score reduce rates? Each 100 point credit score increase reduces rates by around 1.5% - Excellent credit unlocks huge savings. Key Takeaways on 2023 Auto Loan Rates and APRs Credit score heavily influences loan rates - prime borrowers get far lower APRs 2023 new car rates range from 3% for prime buyers up to 20% for subprime Used cars are 1-2% higher than new currently 20%+ down payments maximize rate incentives Pre-approval locks in current rates before future hikes Improving credit by 100+ points before applying generates big savings Understanding current rate trends helps set expectations and budget accurately as you take out a 2023 auto loan. Position yourself to access the best rates for your situation before buying. #Wiack #Car #CarInsurance #CarRental #CarPrice #AutoLoans
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New and used car buyers often want to know - what are the average 2023 car loan interest rates and APRs they can expect to see? Interest rates impact the monthly payment and total loan cost. This guide examines current auto loan APRs, factors that influence rates, and how to secure the best financing in 2023. What is APR? What is the Current Average New Car Loan APR in 2023? For new cars in 2023, average APRs by credit score are: 800+ credit score (prime) - 3% to 5% APR 700-799 credit score (prime) - 4% to 6% APR 620-699 credit score (non-prime) - 6% to 10% APR 600-619 credit score (subprime) - 10% to 14% APR Under 600 credit score (deep subprime) - 14% to 20% APR Shop prime lenders to access interest rates below 5% for new cars based on a strong 700+ credit score. Those under 640 may pay double digit rates from subprime lenders. What is the Current Average Used Car Loan APR in 2023? For used car purchases in 2023, average APRs are: 800+ credit score (prime) - 4% to 7% APR 700-799 credit score (prime) - 5% to 8% APR 620-699 credit score (non-prime) - 8% to 12% APR 600-619 credit score (subprime) - 12% to 16% APR Under 600 credit score (deep subprime) - 16% to 24% APR Used car interest rates run 1-2% higher than new currently. Strong credit still nets rates under 8% from prime lenders. Subprime buyers pay significantly more. How to Secure a Good APR for a Car Loan Prime Car Loan Rates vs Subprime Rates in 2023 Prime borrowers (700+ credit) generally see: New car rates from 3% to 7% APR Used car rates from 4% to 8% APR Subprime borrowers (under 640 credit) generally see: New car rates from 8% to 20% APR Used car rates from 10% to 24% APR Having prime credit saves thousands over the auto loan term by qualifying better rates. Subprime terms carry expensive risk premiums. How Does Credit Score Impact Auto Loan Interest Rates? Credit score influence on APR: 800+ scores offer the lowest rates due to representing ultra prime borrowers. 700-749 scores see minor impacts, with rates 1% higher than 800+. 640-699 scores classify as non-prime with rates 2-4% above prime. Under 640 are subprime with significant rate increases. Scores below 600 see drastic jumps. Improving credit from good to excellent can save 1% or more, while falling from prime to subprime can double rates. Average Auto Loan Term Lengths Typical loan terms and impact on APR: 36 months - Lower rates but higher monthly payment. 48 months - Allows lower payment with slight rate increase. 60 months - Average term length with moderate rates. 72 months - Lowest payment but higher rates from risk. 84 months - Riskiest term with highest rates but lowest payment. Aim for 60 months or less to keep rates down. Budget appropriately to avoid very long terms unless necessary. Understanding Car Loan Terms Do Auto Loan Rates Vary by State? 2023 auto loan rates don’t vary significantly by state, but factors in specific locations can have some influence: State maximum interest rate caps on loans impact rate ceilings. But most are above 15%. Regional economic factors like unemployment may account for small variations. Credit score distributions and financial trends in local areas move rates. Promotions and incentives from lenders in a given state can create minor variances. But any state-level differences amount to less than 1% typically. National lender rates are broadly similar. Down Payment Percentage Effect on Interest Rates Typical down payment tiers and impact on APR: 0-4% down - Highest rates; risky for lender 5-9% down - Slight rate improvement 10-19% down - Lower rates in prime territory 20%+ down - Maximum rate incentive; best terms Larger down payments signal lessened risk and commitment from borrowers. This earns lower interest rates from lenders. How Auto Loan Rates Have Changed 2022 average new car rate - 5.2% APR
2021 average new car rate - 4.1% APR Rates rose over 1% due to: Federal interest rate hikes High inflation Tighter lending restrictions Supply chain constraints Expect rates above 5% for the near term until inflation cools in 2023-2024. Pre-Approval for Lower Rates Getting pre-approved for financing helps: Lock in current rates before future hikes Compare multiple lender rates Focus searches only on approved loan amount Negotiate from a position of strength at the dealership Don’t wait - secure favorable rates now before further increases. FAQs How much does auto loan interest vary from month to month? Very little variance monthly. Market-wide shifts lead to adjustments every few months in 0.25 to 0.5% increments based on macro factors. Which lenders offer the lowest interest rates right now? Online lenders, credit unions, and community banks often offer the most competitive rates versus large national banks. How much does the length of the loan change interest rates? Going from a 60 month term up to 72 or 84 months can increase rates around 0.5% typically. What’s better - longer term with lower payment or higher rate? Go for the shortest term you can afford the monthly payment on. Lower rates save thousands over the life of the loan. How much can improving my credit score reduce rates? Each 100 point credit score increase reduces rates by around 1.5% - Excellent credit unlocks huge savings. Key Takeaways on 2023 Auto Loan Rates and APRs Credit score heavily influences loan rates - prime borrowers get far lower APRs 2023 new car rates range from 3% for prime buyers up to 20% for subprime Used cars are 1-2% higher than new currently 20%+ down payments maximize rate incentives Pre-approval locks in current rates before future hikes Improving credit by 100+ points before applying generates big savings Understanding current rate trends helps set expectations and budget accurately as you take out a 2023 auto loan. Position yourself to access the best rates for your situation before buying. #Wiack #Car #CarInsurance #CarRental #CarPrice #AutoLoans
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CAS NO.93-90-3 2-(N-Methylanilino)ethanol Manufacturer/High quality/Best price/In stock
Quick Details CAS No. 93-90-3 Other Names n-(2-hydroxyethyl)-n-methylaniline MF c9h13no EINECS No. 204-493-5 Place of Origin xuzhou, China Type Pharmaceutical Intermediates, n,n-dimethylaniline Purity 99% Brand Name crovell Model Number n,n-dimethylaniline Application raw materials Appearance light yellow liquid Product Name n,n-dimethylaniline MOQ 0.1 Kg Color Light yellow liquid Shelf Life 2 Years Packing at your requested Assay 99%minn Supply Ability 100 Kilogram/Kilograms per Month Superiority： 1.High quality with competitive price: We are manufacturer and can provide high quality products with factory price. 2.Fast and safe delivery ① Parcels can be sent out within 48 hours after payment. Tracking number is available. ②Secure and discreet shipment. You have various choices of transportation methods. 3.We have clients throughout the world. ① Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet your desire. ②Market feedback and goods feedback are appreciated, meeting customers's requirement is our responsibility. ③High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers. Company Information MIT-IVY INDUSTRY CO.,LTD is a manufacturer and exporter of fine chemical dyes & pharmaceutical intermediates in China. Mainly produce aniline series products and chlorine series products. We are a young company full of vitality and vitality. The company has a group of energetic, well-trained employees and strong technical research and development capabilities. We specialize in the production, development and sales of API intermediates, fine chemicals and plant extracts. Relying on advanced equipment and strict management, adhere to the business philosophy of "openness, tolerance, innovation, and sharing" to create a win-win cooperationplatform.Everything comes from innovation, it is our philosophy ! If you are interested in getting more quotations, please add WHATSAPP:0086-13805212761 or E-MAIL:[email protected] MIT-IVYINDUSTRYCO.,LTDMit-Ivy is a well-known fine chemicals and pharmaceutical intermediates manufacturer with strong R&D support in China. Mainly involved Aniline, Chlorine products. Payment：DA 60 DAYS TEL:008619961957599 E-MAIL:[email protected] 产品 Product CAS N,N-二甲基-1,4-苯二胺 N,N-Dimethyl-1,4-phenylenediamineDMPD 99-98-9 N,N-二甲基苄胺 N,N-Dimethylbenzylamine BDMA 103-83-3 N,N-二甲基甲酰胺 N,N-Dimethylformamide DMF .68-12-2 N,N-二甲基甲酰胺二甲缩醛 DMF-DMA N,N-Dimethylformamidedimethyl acetal (DMF-DMA) 4637-24-5 N,N-二甲基乙酰胺 N,N-Dimethylacetamide DMAC 127-19-5 N,N-二乙基间甲苯甲酰胺 避蚊胺 N,N-diethyl-m-toluamide DEET 134-62-3 N,N-二乙基羟胺 N,N-Diethylhydroxylamine DEHA 3710-84-7 N-甲基-N-羟乙基苯胺 2-(N-甲基苯胺)乙醇 2-(N-methylanilino)ethanol 93-90-3 N-甲基吡咯烷酮 N-methylpyrrolidone 872-50-4 N,N-二甲基苯胺 N,N-Dimethylaniline DMA 121-69-7 N,N-二甲基对甲苯胺 N,N-Dimethyl-p-toluidine DMPT 99-97-8 N,N-二甲基邻甲苯胺 N,N-Dimethyl-o-toluidine DMOT 609-72-3 N,N-二乙基苯胺 N,N-Diethylaniline 91-66-7 N,N-二乙基间甲苯胺 N,N-Diethyl-m-toluidine 91-67-8 N,N-二羟乙基苯胺 N,N-Dihydroxyethylaniline PDEA 120-07-0 N-乙基间甲苯胺 N-乙基-3-甲基苯胺 N-Ethyl-m-toluidine 102-27-2 N-乙基-N-氰乙基苯胺 3-(N-ethylanilino)propiononitrile 148-87-8 N-乙基-N-羟乙基苯胺 N-Ethyl-N-hydroxyethylaniline 92-50-2 N-乙基-N-苄基苯胺 乙基苄基苯胺; N-苄基-N-乙基苯胺 N-ethyl-N-phenylbenzenemethanamine 92-59-1 N-乙基-N-氰乙基间甲苯胺 N-2-cyanoethyl-N-ethyl-m-toluidine 148-69-6 N-乙基-N-苄基间甲苯胺 N-Benzyl-N-ethyl-m-toluidine 119-94-8 N-乙基邻甲苯胺 N-Ethyl-o-toluidine 94-68-8 N-乙基苯胺 N-Ethylaniline 103-69-5 N-甲基苯胺 N-Methylaniline 100-61-8 N,N-二甲基-间甲基苯胺 N,N-DIMETHYL-M-TOLUIDINE 121-72-2 N-甲基二苯胺 N-Methyldiphenylamine 552-82-9 N-甲基-邻甲基苯胺 N-METHYL-O-TOLUIDINE 611-21-2 N-甲基-对甲基苯胺 N-METHYL-P-TOLUIDINE 623-08-5 4-甲基-N-苯基苯胺 N-PHENYL-P-TOLUIDINE 620-84-8 N-异丙基苯胺 N-ISOPROPYLANILINE 768-52-5 N,N-二氰乙基苯胺 N,N-Dicyanoethylaniline 1555-66-4 N,N-二羟乙基-对甲基苯胺 N,N-DIHYDROXYETHYL-P-TOLUIDINEDHEPT .3077-12-1 N-乙基-2-硝基苯胺 N-Ethyl-2-Nitro-Benzenamine 10112-15-9 2,4-二氯苯胺 2,4Dichloroaniline 554-00-7 N-(2-羟乙基)乙二胺 AEEA 111-41-1 1,3-二甲基-2-咪唑啉酮N,N-二甲基亚乙基脲1,3-二甲基-2-咪唑啉酮（DMI) 1,3-Dimethyl-2-imidazolidinone DMI N,N'-dimethylimidazolidinone 80-73-9 N,N-二苄基羟胺 N,N-Dibenzylhydroxylamine 621-07-8 对甲苯胺 P-Toluidine PT 106-49-0 邻甲苯胺 O-Toluidine OT 95-53-4 二乙基乙醇胺 DEEA;DEAE 100-37-8 甲萘胺 AlphaNaphthylamine 134-32-7 间二氯苯 1,3-Dichlorobenzene MDCB 541-73-1 间甲苯胺 M-Toluidine MT 108-44-1 间苯二胺 M-PHENYLENEDIAMINE MPDA 108-45-2 多乙烯多胺 PEPA 68131-73-7 二乙烯三胺(DETA) Diethylenetriamine DETA 111-40-0 三乙烯二胺 Triethylenediamine 280-57-9 三乙烯四胺 TriethylenetetramineTETA 112-24-3 四乙烯五胺 TEPA 112-57-2 Read the full article
#2-(Methylphenylamino)ethanol#2-(N-Methyl-N-phenylamino)ethanol#2-(N-methylanilino)-(6CI#2-(N-methylanilino)ethanol#204-493-5#7CI#8CI#93-90-3#Bestprice#C9H13NO#CASNO.93-90-3#Ethanol#Ethanol2-(N-methylanilino)-#Highquality#HighqualityN-Methyl-N-HydroxyethylAniline#HighqualityN-Methyl-N-HydroxyethylAnilinesupplierinChina#instock#N-(2-Hydroxyethyl)-N-methylaniline#N-Hydroxyethyl-N-methylaniline#N-methyl-N-(2-hydroxyethyl)aniline#N-methyl-N-hydroxyethylAniline#N-Methyl-N-HydroxyethylAnilinesupplier#N-Methyl-N-phenyl-2-aminoethanol#N-Methyl-N-phenyl-2-hydroxyethylamine#N-Phenyl-N-methyl-ethanolamine#NSC9274
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iQOO Z7 5G Is All Set To Launch In India On March 21 For Very Affordable Price
You read the right. The all-new iQOO Z7 5G is confirmed to launch in India this March 21st.
An advertisement for the company has confirmed that the iQOO Z7 will go on sale in the nation on March 21. This information serves as the iQOO Z7 5G launch in India for the upcoming smartphone.
The upcoming phone on the market is the iQOO Z7. The iQOO Z series now includes this device, making it a superb smartphone that combines a beautiful design with top-notch technology.
The performance on this phone will be unmatched. The 6.58-inch screen of the iQOO Z7 is expected to weigh about 185.5 g. (6.56 oz).
The phone has a respectable resolution of 1080 x 2408 pixels and a 20.9 ratio and is powered by Android 11, Fun touch 11.1 (International), Origin OS (China), and iQOO 1.0.
The Qualcomm Snapdragon 780 processor, which has an octa-core CPU and an Adreno 620 GPU, will power the iQOO Z7.
As we now know that iQOO Z7 5G is confirmed to launch in India, let’s check out IQOO Z7’s features, specs, and iQOO Z7 5G price in India.
Also Read: iQOOz6 Price, Specs In India
iQOO Z7 Specifications: What We Know
If you’re looking for a new phone, you might be curious about the iQOO Z7 specifications. We’ll examine the phone and its features in more detail as well as provide a list of the iQOO Z7’s specifications in this blog post.
The 6.58-inch Full HD display on the iQOO Z7 has a 1080 x 2400-pixel resolution. The screen has a punch-hole design on top and 400 PPI of pixel density. On the right side of the phone are the power and volume rockers.
A design with a 20:9 aspect ratio offers an 84% screen-to-body ratio. The phone has facial recognition technology via a selfie camera and a side-mounted fingerprint sensor built under the power button for security.
iQOO Z7 Features: The Features We Can Expect On iQOO Z7
You’ll adore the iQOO Z7 if you’re looking for a premium speakerphone that’s ideal for professional use.
This phone will become popular among professionals who are busy thanks to its premium audio quality, user-friendly features, and stylish design. We’ll examine the iQOO Z7 in more detail in this article so you can decide if it’s the best phone for your requirements.
We’ll talk about the phone’s call quality, sound quality, and overall performance so you can be certain you’re picking the right phone for your company.
The smartphone has a potent Qualcomm Snapdragon 780G chipset and a sizable 8 GB of RAM to accommodate your various multitasking requirements.
For seamless operation, the brand also includes an intelligent battery layout and expandable storage.
Speaking of iQOO Z7 5G confirmed to launch in India, let’s checkout its features like display, camera, battery, and more.
Display and Camera
The 6.58-inch IPS LCD on the iQOO Z7 has a 20 aspect ratio with a 1080 x 2400 pixel resolution. Additionally, the smartphone’s frameless display has a hole in the top center that integrates with the front camera, as well as a pixel density of 400 ppi and a refresh rate of 120Hz.
On the back of the iQOO Z7, there is a triple camera setup with an LED flash. It has a 64MP wide-angle f/1.8 camera, an 8MP ultra-wide-angle f/2.2 camera, and a 2MP macro camera.
For taking stunning portrait photos, there is a single 16MP f/2.0 wide-angle camera on the front.
Battery and Configuration
The iQOO Z7 5G comes with a lithium polymer battery with a 4500mAh charging capacity.
The battery is fast charging compatible and by nature non-removable.
The Qualcomm Snapdragon 780G chipset, which also supports 8 GB of RAM and the Adreno 642 GPU, powers the iQOO Z7.
Internal processing for the smartphone is driven by a triple-setup Kryo 670 octa-core CPU, which can operate at up to 2.4GHz.
Connectivity and Storage
The iQOO Z7 has 128 GB of internal memory. With a micro SD card, users can increase this storage up to 512 GB.
The smartphone supports 5G and 4G VoLTE network connectivity for video and voice communication, in addition to Wi-Fi, Bluetooth v5.2, mobile hotspot, A-GPS using GLONASS, and USB Type-C.
iQOO Z7 Price In India 2023
Want to purchase an iQOO Z7? For you to make an informed choice, we have the most recent prices and specifications for the device.
The iQOO Z7 5G price in India is expected to be under 20,000.
iQOO Z7 5G confirmed to launch in India is February 9, 2023. This is the iQOO Z7’s entry-level model, which will reportedly come in black and gold and have 8GB of RAM and 128GB of internal storage.
The IQOO Z7 is a smartphone with outstanding performance. It boasts a striking display, a potent processor, and an excellent camera. Additionally, it has cutting-edge features like dual SIM card support, fingerprint authentication, and quick 4G connectivity.
For those looking for a powerful smartphone at a good price, the iQOO Z7 is a fantastic option. Check out our blog for the most recent prices and details on the iQOO Z7 whether you’re shopping for a new smartphone or a high-performance laptop.
Also Read: iQOOz6 Launch Date In India
Last Words On iQOO Z7 5G Confirmed To Launch In India
You now have a clear understanding of iQOO Z7 5G launch in India and iQOO Z7 5G price in India.
We’ve mentioned every feature that you need to know before purchasing the iQOO Z7 5G.
Based on the features and pricing, we can say that this phone could be a deal breaker for many people because it provides more features for a lower price.
The iQOO Z7 would cost less than Rs 20,000, according to the CEO of iQOO India. Therefore, it appears that the product will compete in the Indian market with the Redmi Note 12 5G and the upcoming POCO X5 5G.
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I posted 12,376 times in 2022
That's 2,273 more posts than 2021!
63 posts created (1%)
12,313 posts reblogged (99%)
Blogs I reblogged the most:
@feenyxblue
@that-g3-obsessive
@magnetickid
@iamdeltas
@sarah-sandwich
I tagged 1,342 of my posts in 2022
#dracula - 620 posts
#history - 132 posts
#to find later - 92 posts
#am writing - 84 posts
#funny - 57 posts
#catholic - 39 posts
#science - 35 posts
#resident evil - 34 posts
#dc - 31 posts
#kingdom hearts - 30 posts
Longest Tag: 122 characters
#she holds the braincell as it's in her city and sora is the closest to her tech/society understanding but he's bad at tech
I sent 2 gifts in 2022
My Top Posts in 2022:
#5
I'll be honest. DD has put a new spin on Mina asking to be removed from the narrative.
Look there is a world of difference between:
"we don't want to trouble this woman, so we won't tell her stuff"
and
" As I am now turning into a vampire against my will, there is a chance I could be compelled to tell him what YOU are planning. None of us want this so I'm getting ahead of the game and deliberately avoiding all of this."
Even if they accomplish the same goal.
195 notes - Posted October 5, 2022
#4
I commissioned epsilynn on Twitter (link) to draw Jesse from Control and Alan Wake swapping Jackets. I think they did a good job, don't you?
235 notes - Posted March 31, 2022
#3
If you see this, tell me what was your favorite, unpopular, piece of media when you were a kid. Mine was Sherlock Holmes in the 22nd century!
276 notes - Posted May 12, 2022
#2
People who are reading Dracula for the first time through Dracula Daily: Oh man. No Johnathan update. At least we get a fun lesbian relationship with this Mina girl!
People who have read Dracula: MINA!!! MINA!!!! YOU ARE HERE! GIVE US YOUR BLESSINGS OF WISDOM, COURAGE, AND LOVE!!! HOW ARE WE SO BLEST TO KNOW OF YOUR EXISTENCE!
332 notes - Posted May 9, 2022
My #1 post of 2022
Look me in the eye and tell me Miles doesn't have an Aro/Ace read. This is from the spirit of Justice DLC aka Miles most recent Canon thing.
See the full post
832 notes - Posted May 8, 2022
Get your Tumblr 2022 Year in Review →
#tumblr2022#year in review#my 2022 tumblr year in review#your tumblr year in review#To find later#Wow I thought my original posts would be non existent#Or just the blaze posts
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Let's count to a thousand. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 it's getting boring. 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 314 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337 338 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 373 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 397 398 399 400 401 402 403 404 405 406 406 407 408 409 410 411 412 413 414 415 416 417 418 419 420 421 422 423 424 425 426 427 428 429 430 431 432 433 434 435 436 437 438 439 440 441 442 443 445 446 447 448 449 450 451 452 453 454 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476 477 478 479 480 481 482 483 484 485 486 487 489 490 491 492 493 494 495 496 497 498 499 500 Half done. 501 502 503 504 505 506 507 508 509 510 511 512 513 514 515 516 517 518 519 520 521 522 523 524 526 527 528 529 530 531 532 533 534 535 536 537 538 539 540 541 542 543 544 545 546 547 548 549 550 551 552 553 554 555 556 557 558 559 560 561 562 563 564 565 566 567 568 5*69* 570 571 572 573 574 575 576 578 579 580 581 582 583 584 585 586 587 589 590 592 593 593 594 595 596 597 598 599 600 601 602 603 604 605 606 607 608 609 610 611 612 613 614 615 616 617 618 619 620 621 622 623 624 625 626 627 628 629 630 631 632 633 634 635 636 367 638 639 640 641 642 643 644 645 646 647 648 649 650 651 652 653 654 655 656 657 658 659 660 661 662 663 664 665 666 667 668 669 670 671 672 673 674 675 676 677 678 679 680 681 682 683 684 685 686 687 689 690 691 692 693 694 695 696 697 698 699 700 701 702 703 704 705 706 709 710 711 712 713 714 715 716 717 718 719 720 721 722 723 724 725 726 727 78 729 730 731 732 733 734 735 736 737 738 739 740 741 742 743 744 745 746 747 748 749 750 751 752 753 754 755 756 758 759 760 761 762 763 764 765 766 767 768 769 770 771 772 773 774 775 776 777 (jackpot) 778 779 780 781 782 783 784 785 786 787 789 790 791 792 793 794 795 796 797 798 799 800 801 802 803 804 805 806 807 808 809 810 811 812 813 814 815 816 817 818 819 820 821 822 823 824 825 826 827 829 830 831 832 833 834 835 836 837 838 839 840 841 842 843 844 845 846 846 847 849 850 851 852 853 854 855 856 857 858 859 860 861 862 863 864 865 866 868 869 870 871 872 873 874 875 876 878 879 880 881 882 883 884 885 886 887 888 889 890 891 892 893 894 895 896 897 898 899 900 901 902 903 904 905 906 907 908 909 910 911 912 913 914 915 916 917 918 919 920 921 922 923 924 925 926 927 928 929 930 931 932 933 934 935 936 936 937 938 939 940 941 942 943 944 945 946 947 948 949 950 951 952 953 954 955 956 957 958 959 960 961 962 963 964 965 966 967 968 969 970 971 972 973 974 975 976 977 978 979 980 981 982 983 984 985 986 987 988 989 990 991 992 993 994 995 996 997 998 999 1000 Took me about ~ 45 min. Now I can die in peace
#circa 2016#NightcoreReality#Nightcore - Wonderland#fav#fragment#nightcore music#nightcore#youtube comments#youtube comment#nostalgiacore#webcore#kidcore
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Should I read 1984 now or should I read 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 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Two men shot on a rural Alberta road found on Saturday were hunting to feed their families after a COVID-19 job loss, the day before they were found dead.
Jake Sansom, 39, and Morris Cardinal, 57, were discovered on the road near a black pickup truck early Saturday morning near Township Road 622 and Range Road 84 north of Glendon with gunshot wounds. The pair spent Friday fishing and hunting for moose near Seibert Lake, after Sansom was laid off from his job as a heavy duty mechanic in Nobleford amid the global pandemic. Both men have Métis ancestry and hunting rights.
The Major Crimes Unit and #Bonnyville RCMP are seeking public assistance for:
Trail, dash cams and video surveillance from 8 p.m. March 27 to 4 a.m. March 28, 2020, from the following areas: the MD of #Bonnyville, RR 84, RR 85 RR 90, TWP 614, TWP 620 and TWP 622. #CanYouHelp
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