#2-(N-Methyl-N-phenylamino)ethanol

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CAS NO.93-90-3 2-(N-Methylanilino)ethanol Manufacturer/High quality/Best price/In stock

Quick Details   CAS No. 93-90-3 Other Names n-(2-hydroxyethyl)-n-methylaniline MF c9h13no EINECS No. 204-493-5 Place of Origin xuzhou, China Type Pharmaceutical Intermediates, n,n-dimethylaniline Purity 99% Brand Name crovell Model Number n,n-dimethylaniline Application raw materials Appearance light yellow liquid Product Name n,n-dimethylaniline MOQ 0.1 Kg Color Light yellow liquid Shelf Life 2 Years Packing at your requested Assay 99%minn Supply Ability 100 Kilogram/Kilograms per Month   Superiority： 1.High quality with competitive price: We are manufacturer and can provide high quality products with factory price. 2.Fast and safe delivery ① Parcels can be sent out within 48 hours after payment. Tracking number is available. ②Secure and discreet shipment. You have various choices of transportation methods. 3.We have clients throughout the world. ① Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet your desire. ②Market feedback and goods feedback are appreciated, meeting customers's requirement is our responsibility. ③High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers. Company Information MIT-IVY INDUSTRY CO.,LTD is a manufacturer and exporter of fine chemical dyes & pharmaceutical intermediates in China. Mainly produce aniline series products and chlorine series products. We are a young company full of vitality and vitality. The company has a group of energetic, well-trained employees and strong technical research and development capabilities. We specialize in the production, development and sales of API intermediates, fine chemicals and plant extracts. Relying on advanced equipment and strict management, adhere to the business philosophy of "openness, tolerance, innovation, and sharing" to create a win-win cooperationplatform.Everything comes from innovation, it is our philosophy ! If you are interested in getting more quotations, please add WHATSAPP:0086-13805212761 or E-MAIL:info@mit-ivy.com MIT-IVYINDUSTRYCO.,LTDMit-Ivy is a well-known fine chemicals and pharmaceutical intermediates manufacturer with strong R&D support in China. Mainly involved Aniline, Chlorine products. Payment：DA 60 DAYS TEL:008619961957599   E-MAIL:info@mit-ivy.com 产品 Product CAS N,N-二甲基-1,4-苯二胺 N,N-Dimethyl-1,4-phenylenediamineDMPD 99-98-9 N,N-二甲基苄胺 N,N-Dimethylbenzylamine  BDMA 103-83-3 N,N-二甲基甲酰胺   N,N-Dimethylformamide  DMF .68-12-2 N,N-二甲基甲酰胺二甲缩醛 DMF-DMA N,N-Dimethylformamidedimethyl acetal  (DMF-DMA) 4637-24-5 N,N-二甲基乙酰胺 N,N-Dimethylacetamide   DMAC 127-19-5 N,N-二乙基间甲苯甲酰胺 避蚊胺 N,N-diethyl-m-toluamide    DEET 134-62-3 N,N-二乙基羟胺 N,N-Diethylhydroxylamine  DEHA 3710-84-7 N-甲基-N-羟乙基苯胺 2-(N-甲基苯胺)乙醇 2-(N-methylanilino)ethanol 93-90-3 N-甲基吡咯烷酮 N-methylpyrrolidone 872-50-4 N,N-二甲基苯胺 N,N-Dimethylaniline   DMA 121-69-7 N,N-二甲基对甲苯胺 N,N-Dimethyl-p-toluidine  DMPT 99-97-8 N,N-二甲基邻甲苯胺 N,N-Dimethyl-o-toluidine   DMOT 609-72-3 N,N-二乙基苯胺 N,N-Diethylaniline 91-66-7 N,N-二乙基间甲苯胺 N,N-Diethyl-m-toluidine 91-67-8 N,N-二羟乙基苯胺 N,N-Dihydroxyethylaniline   PDEA 120-07-0 N-乙基间甲苯胺 N-乙基-3-甲基苯胺 N-Ethyl-m-toluidine 102-27-2 N-乙基-N-氰乙基苯胺 3-(N-ethylanilino)propiononitrile 148-87-8 N-乙基-N-羟乙基苯胺 N-Ethyl-N-hydroxyethylaniline 92-50-2 N-乙基-N-苄基苯胺 乙基苄基苯胺; N-苄基-N-乙基苯胺 N-ethyl-N-phenylbenzenemethanamine 92-59-1 N-乙基-N-氰乙基间甲苯胺 N-2-cyanoethyl-N-ethyl-m-toluidine 148-69-6 N-乙基-N-苄基间甲苯胺 N-Benzyl-N-ethyl-m-toluidine 119-94-8 N-乙基邻甲苯胺 N-Ethyl-o-toluidine 94-68-8 N-乙基苯胺 N-Ethylaniline 103-69-5 N-甲基苯胺 N-Methylaniline 100-61-8 N,N-二甲基-间甲基苯胺 N,N-DIMETHYL-M-TOLUIDINE 121-72-2 N-甲基二苯胺 N-Methyldiphenylamine 552-82-9 N-甲基-邻甲基苯胺 N-METHYL-O-TOLUIDINE 611-21-2 N-甲基-对甲基苯胺 N-METHYL-P-TOLUIDINE 623-08-5 4-甲基-N-苯基苯胺 N-PHENYL-P-TOLUIDINE 620-84-8 N-异丙基苯胺 N-ISOPROPYLANILINE 768-52-5 N,N-二氰乙基苯胺 N,N-Dicyanoethylaniline 1555-66-4 N,N-二羟乙基-对甲基苯胺 N,N-DIHYDROXYETHYL-P-TOLUIDINEDHEPT .3077-12-1 N-乙基-2-硝基苯胺 N-Ethyl-2-Nitro-Benzenamine 10112-15-9 2,4-二氯苯胺 2,4Dichloroaniline 554-00-7 N-(2-羟乙基)乙二胺 AEEA 111-41-1 1,3-二甲基-2-咪唑啉酮N,N-二甲基亚乙基脲1,3-二甲基-2-咪唑啉酮（DMI) 1,3-Dimethyl-2-imidazolidinone  DMI N,N'-dimethylimidazolidinone 80-73-9 N,N-二苄基羟胺 N,N-Dibenzylhydroxylamine 621-07-8 对甲苯胺 P-Toluidine  PT 106-49-0 邻甲苯胺 O-Toluidine  OT 95-53-4 二乙基乙醇胺 DEEA;DEAE 100-37-8 甲萘胺 AlphaNaphthylamine 134-32-7 间二氯苯 1,3-Dichlorobenzene   MDCB 541-73-1 间甲苯胺 M-Toluidine  MT 108-44-1 间苯二胺 M-PHENYLENEDIAMINE  MPDA 108-45-2 多乙烯多胺 PEPA 68131-73-7 二乙烯三胺(DETA) Diethylenetriamine  DETA 111-40-0 三乙烯二胺 Triethylenediamine 280-57-9 三乙烯四胺 TriethylenetetramineTETA 112-24-3 四乙烯五胺 TEPA 112-57-2 Read the full article

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Synthesis and Characterization of New Triazinane-2-Thione and Oxadiazinane 4-Thiones from Benzimidazole-Juniper Publishers

JUNIPER PUBLISHERS-OPEN ACCESS JOURNAL OF DRUG DESIGNING & DEVELOPMENT

Abstract

The present study a new strategy for the synthesis of most potent nitrogen heterocycles i.e., triazinane-2-thiones and oxadiazinanes-4- thiones (3-4) were efficiently synthesized by cyclic condensation based on classical Mannich amino methylation of N, N' unsymmetrical Thio ureas. The synthesized compounds have been characterized by analytical and spectral (IR, 1HNMR and Mass) data.

Keywords:  Synthesis; Characterization; Triazinane-2-thione; Benzimidazole    

Introduction

Demand for higher efficiency, economy and selectivity in the synthesis of novel molecular scaffolds drives organic chemistry, particularly nitrogen-containing molecules has been of longstanding interest to organic chemists due to their great importance in chemistry and biology [1]. Many of these heterocyclic compounds exhibit various biological activities [2,5]. Little work has been published in the area of 1,3,5 triazinane- 2-phones showing antimicrobial activity [6], Biocidal [7] and enantio-differentiating coupling reagents [8]. The potent Heterocycles having, structural unit has a significant place among pharmaceutically important synthetic and natural materials [9].

Materials and Methods

Melting points of the synthesized compounds are determined in open capillary tubes and are uncorrected. Reaction Progress was observed by TLC plates, Bruker 300MHz instrument was used to record 1HNMR spectra in DMSO/CDCl3 using TMS as internal standard. Chemical shifts (5) are expressed in ppm. Perkin Elmer BX series FT-IR was to record IR spectra, Elemental analysis were performed on a PerkinElmer 240CHN analyzer Figure 1.

Experimental section

Synthesis of 1-(5-(4-(1H-benzo[d]imidazol-2-yl)phenyl) amino)thiazol-2-yl)-3-phenyl thiourea (2): A mixture of compound [10] (1) (0.01mmol) and sodium hydride (0.5g, 20mmol) in Ethanol (80ml) was heated under reflux for 30min and cooled. Phenyl isothiocynate (0.01mmol) was added and refluxing continued for a further 4h. The solvent was evaporated off and the residue dissolved in DCM (50ml) and washed with dilute HCl. The organic phase was dried (MgSO4) and the solvent evaporated off to give the desired compound (2). The progress of the reaction was monitored by TLC and recrystallized from ethanol.

Synthesis of 1-(5-(4-(1H-benzo[d]imidazol-2-yl) Phenylamino)thiazol-2-yl)-5-methyl-3-phenyl-1,3,5 triazinane-2-thione (3): A mixture of compound (2) in (1mmol), 30% formaldehyde (2mmol) and methyl amine (1mmol) and (0.01mole) NaOH were taken in ethanol (30ml) and refluxed for about 5-6h. The progress of the reaction was monitored by TLC. After completion of the reaction it was cooled and the product was filtered. The crude product was passed through silica gel by column and the product was eluted from 60% ethyl acetate and hexane.

Synthesis of 3-(5-((4-(1H-benzo[d]imidazol-2-yl) phenyl)amino)thiazol-2-yl)-5-phenyl-1,3,5-oxadiazmane- 4-thione(4): A mixture of compound (2) in (1mmol), 30% formaldehyde (2mmol) were taken in ethanol (30ml) and add 1ml concentrated HCl (5ml) and refluxed for about 5-6hr at 100110 °C. The progress of the reaction was monitored by TLC. After completion of the reaction it was cooled and neutralized with 10% NaOH. The product was filtered. The crude product was passed through silica gel by column and the product was eluted from 60% ethyl acetate and hexane. These compounds were purified by recrystallisation from suitable solvents. Structures of the synthesized compounds [2-4(a-e] have been confirmed on the basis of analytical and spectral (IR, 1HNMR and Mass) data (Table 1).   

Results and Discussion

In the present study, it has been discussed that the synthesis of various benzimidazole fused triazinane 2-thione heterocyclic moieties by cyclic condensation based on classical Mannich amino methylation of N,N' unsymmetrical this ureas (2) with 30% HCHO and methyl amine in ethanol. An aliphatic amine has been yielded in the condensation between methyl amine and formaldehyde, it cyclizes immediately to produce corresponding 1,3,5-triazinane since imine is unstable. With respect to biological activity benzimidazole fused heterocyclic compounds such as triazinane derivatives are of very important than the cyclic compounds [11,12] (Table 2).   

Conclusion

The research study reported efficiently synthesized new analogs of triazinane and oxadiazinane by classical amino methylation with different aerial-N,N' unsymmetrical thioureas by taking benzimidazole as starting material. All the compounds were characterized by standard spectroscopic techniques.   

Acknowledgement

The authors are grateful acknowledge to the Department of chemistry Kakatiya university, Warangal for their constant support during this research work.

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