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reasonsforhope · 4 months ago
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"A large clinical trial in South Africa and Uganda has shown that a twice-yearly injection of a new pre-exposure prophylaxis drug gives young women total protection from HIV infection.
The trial tested whether the six-month injection of lenacapavir would provide better protection against HIV infection than two other drugs, both daily pills. All three medications are pre-exposure prophylaxis (or PrEP) drugs.
Physician-scientist Linda-Gail Bekker, principal investigator for the South African part of the study, tells Nadine Dreyer what makes this breakthough so significant and what to expect next.
Tell us about the trial and what it set out to achieve
The Purpose 1 trial with 5,000 participants took place at three sites in Uganda and 25 sites in South Africa to test the efficacy of lenacapavir and two other drugs.
Lenacapavir (Len LA) is a fusion capside inhibitor. It interferes with the HIV capsid, a protein shell that protects HIV’s genetic material and enzymes needed for replication. It is administered just under the skin, once every six months.
The randomised controlled trial, sponsored by the drug developers Gilead Sciences, tested several things.
The first was whether a six-monthly injection of lenacapavir was safe and would provide better protection against HIV infection as PrEP for women between the ages of 16 and 25 years than Truvada F/TDF, a daily PrEP pill in wide use that has been available for more than a decade.
Secondly, the trial also tested whether Descovy F/TAF, a newer daily pill, was as effective as F/TDF...
The trial had three arms. Young women were randomly assigned to one of the arms in a 2:2:1 ratio (Len LA: F/TAF oral: F/TDF oral) in a double blinded fashion. This means neither the participants nor the researchers knew which treatment participants were receiving until the clinical trial was over.
In eastern and southern Africa, young women are the population who bear the brunt of new HIV infections. They also find a daily PrEP regimen challenging to maintain, for a number of social and structural reasons.
During the randomised phase of the trial none of the 2,134 women who received lenacapavir contracted HIV. There was 100 percent efficiency.
By comparison, 16 of the 1,068 women (or 1.5%) who took Truvada (F/TDF) and 39 of 2,136 (1.8%) who received Descovy (F/TAF) contracted the HIV virus...
What is the significance of these trials?
This breakthrough gives great hope that we have a proven, highly effective prevention tool to protect people from HIV.
There were 1.3 million new HIV infections globally in the past year. Although that’s fewer than the 2 million infections seen in 2010, it is clear that at this rate we are not going to meet the HIV new infection target that UNAIDS set for 2025 (fewer than 500,000 globally) or potentially even the goal to end Aids by 2030...
For young people, the daily decision to take a pill or use a condom or take a pill at the time of sexual intercourse can be very challenging.
HIV scientists and activists hope that young people may find that having to make this “prevention decision” only twice a year may reduce unpredictability and barriers.
For a young woman who struggles to get to an appointment at a clinic in a town or who can’t keep pills without facing stigma or violence, an injection just twice a year is the option that could keep her free of HIV.
What happens now?
The plan is that the Purpose 1 trial will go on but now in an “open label” phase. This means that study participants will be “unblinded”: they will be told whether they have been in the “injectable” or oral TDF or oral TAF groups.
They will be offered the choice of PrEP they would prefer as the trial continues.
A sister trial is also under way: Purpose 2 is being conducted in a number of regions including some sites in Africa among cisgender men, and transgender and nonbinary people who have sex with men.
It’s important to conduct trials among different groups because we have seen differences in effectiveness. Whether the sex is anal or vaginal is important and may have an impact on effectiveness.
How long until the drug is rolled out?
We have read in a Gilead Sciences press statement that within the next couple of months [from July 2024] the company will submit the dossier with all the results to a number of country regulators, particularly the Ugandan and South African regulators.
The World Health Organization will also review the data and may issue recommendations.
We hope then that this new drug will be adopted into WHO and country guidelines.
We also hope we may begin to see the drug being tested in more studies to understand better how to incorporate it into real world settings.
Price is a critical factor to ensure access and distribution in the public sector where it is badly needed.
Gilead Sciences has said it will offer licences to companies that make generic drugs, which is another critical way to get prices down.
In an ideal world, governments will be able to purchase this affordably and it will be offered to all who want it and need protection against HIV."
-via The Conversation, July 3, 2024
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batboyblog · 6 months ago
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Things Biden and the Democrats did, this week #19
May 17-24 2024
President Biden wiped out the student loan debt of 160,000 more Americans. This debt cancellation of 7.7 billion dollars brings the total student loan debt relieved by the Biden Administration to $167 billion. The Administration has canceled student loan debt for 4.75 million Americans so far. The 160,000 borrowers forgiven this week owned an average of $35,000 each and are now debt free. The Administration announced plans last month to bring debt forgiveness to 30 million Americans with student loans coming this fall.
The Department of Justice announced it is suing Ticketmaster for being a monopoly. DoJ is suing Ticketmaster and its parent company Live Nation for monopolistic practices. Ticketmaster controls 70% of the live show ticket market leading to skyrocketing prices, hidden fees and last minute cancellation. The Justice Department is seeking to break up Live Nation and help bring competition back into the market. This is one of a number of monopoly law suits brought by the Biden administration against Apple in March and Amazon in September 2023.
The EPA announced $225 million in new funding to improve drinking and wastewater for tribal communities. The money will go to tribes in the mainland US as well as Alaska Native Villages. It'll help with testing for forever chemicals, and replacing of lead pipes as well as sustainability projects.
The EPA announced $300 million in grants to clean up former industrial sites. Known as "Brownfield" sites these former industrial sites are to be cleaned and redeveloped into community assets. The money will fund 200 projects across 178 communities. One such project will transform a former oil station in Philadelphia’s Kingsessing neighborhood, currently polluted with lead and other toxins into a waterfront bike trail.
The Department of Agriculture announced a historic expansion of its program to feed low income kids over the summer holidays. Since the 1960s the SUN Meals have served in person meals at schools and community centers during the summer holidays to low income children. This Year the Biden administration is rolling out SUN Bucks, a $120 per child grocery benefit. This benefit has been rejected by many Republican governors but in the states that will take part 21 million kids will benefit. Last year the Biden administration introduced SUN Meals To-Go, offering pick-up and delivery options expanding SUN's reach into rural communities. These expansions are part of the Biden administration's plan to end hunger and reduce diet-related disease by 2030.
Vice-President Harris builds on her work in Africa to announce a plan to give 80% of Africa internet access by 2030, up from just 40% today. This push builds off efforts Harris has spearheaded since her trip to Africa in 2023, including $7 billion in climate adaptation, resilience, and mitigation, and $1 billion to empower women. The public-private partnership between the African Development Bank Group and Mastercard plans to bring internet access to 3 million farmers in Kenya, Tanzania, and Nigeria, before expanding to Uganda, Ethiopia, and Ghana, and then the rest of the continent, bring internet to 100 million people and businesses over the next 10 years. This is together with the work of Partnership for Digital Access in Africa which is hoping to bring internet access to 80% of Africans by 2030, up from 40% now, and just 30% of women on the continent. The Vice-President also announced $1 billion for the Women in the Digital Economy Fund to assure women in Africa have meaningful access to the internet and its economic opportunities.
The Senate approved Seth Aframe to be a Judge on the US Court of Appeals for the First Circuit, it also approved Krissa Lanham, and Angela Martinez to district Judgeships in Arizona, as well as Dena Coggins to a district court seat in California. Bring the total number of judges appointed by President Biden to 201. Biden's Judges have been historically diverse. 64% of them are women and 62% of them are people of color. President Biden has appointed more black women to federal judgeships, more Hispanic judges and more Asian American judges and more LGBT judges than any other President, including Obama's full 8 years in office. President Biden has also focused on backgrounds appointing a record breaking number of former public defenders to judgeships, as well as labor and civil rights lawyers.
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topazadine · 2 months ago
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Writing Notes: Seasons
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I noticed a few leaves falling from my tree, which means only one thing: it's time.
Time for fall. My favorite, blessed, most beloved season. Pumpkin spice lattes! Candy apples! Cherry pie! Haunted houses! Chilly weather that makes me snuggle up into my hoodie! Candy!
And, of course, it means that I have to share some writing notes with you about seasons.
So today, we're going to share a few different perspectives on seasons. We'll talk about the "traditionally accepted" associations for seasons, but also share other options and how you can infuse them into your work.
Why Use Seasons at All?
You don't have to if you don't want to. Maybe you want to focus entirely on the plot. But, you might add some hints of it for these reasons.
Gives a sense of place. This allows you to show how this place is impacted by particular seasons. Winter in Kampala, Uganda, is going to be wildly different than in Cedar Rapids, Iowa. Offers worldbuilding options. In a fantasy setting, seasons are an element of worldbuilding. (Just look at Game of Thrones.) There may be different dangers according to seasons, or unique holidays that can allow you to demonstrate how people interact with this world. Provides templates for description. You can get a lot of mileage out of showing a nice grassy field in spring or the leaves fluttering down during autumn. Don't go on for ages, but you can certainly add a few little flickers here and there. (just remember to put them in the right places for maximum momentum.) Deepens characterization. How characters feel about and interact with the seasons can tell us a lot about who they are. Someone who loves winter could love it because then they can ski, or because they want to cuddle up and be left alone. Someone who loves summer might like lounging around on the porch eating ice cream, or they might like it because it's time to go surfing! Suggests new challenges. If your character lives in Montana, winter is going to be horribly cruel. "The Hunter's Wife" by Anthony Doerr is all about how the seasons challenge the characters and help them grow. But in your story, it might be summer that's the worst. Or fall, or spring, or all of them but in different ways. Creates subtle symbolism. The season of your story can use certain symbolism depending on what kind of plot you have and what your overall theme is, as we'll discuss now.
So, now that we understand why seasons are important, let's look at each one and consider why it might be the best time for your story.
I will note that I am coming from the perspective as a person in the Midwestern United States. What I associate with the seasons, particularly the descriptions, may be utterly irrelevant to you depending on where you are from. If I made a wholly comprehensive list considering the entire world, we'd be here all day.
Keep that in mind and workshop some options for your setting and personal associations.
I'm not omniscient, so take what seems useful to you and leave the rest.
Spring
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Ah, the flowers are blooming, the world is warming up, and we're finally crawling out of doors now that we're not buried in slush. Spring is generally associated with positive emotions, but there could be some dangers here, too.
To get some good symbolism, focus on spring's unique place between two fixed, more stable seasons, where we know what to expect: winter and summer.
There is a fragility and shifting balance in spring that can veer good or bad depending on what you're trying to show. Spring also has a sense of expectation, which can pay off (good summer) or fail (icky bad summer).
Associations
Positive
Warmth
Renewal
Hope
Rebirth
Childhood
Innocence
Potential
Change
New beginnings
Reunions
Optimism
Negative
Fluctuating emotions (spring can be quite unpredictable!)
New challenges on the horizon
Feeling exposed
"Nakedness"
Vulnerability
Growing pains
Feeling underappreciated, like a stepping stone to summer
Ferocity (like intense spring storms)
The fragility of life (not every baby animal will survive)
Descriptions
Positive
Wildflowers pushing through the soil
Baby animals
Trees blooming
New blades of grass
Budding leaves
Sunny skies
Life-affirming rain
Warming breezes
Slightly chilly nights
Weak sunrises
Days growing longer
Richly scented flowers
Negative
Sudden cold snaps
Dreary weather
Grey skies
Hard rain that traps one inside
Snow (a reminder of the past)
Flooding
Melting snow revealing last year's trash
Cold mornings
Shivering
Being too hot or too cold
Hard ground
Mud
Summer
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Summer fun! Those lucky enough to live by a beach want to splash in the water or go kayaking above the cool waves. We can drink an ice cold soda as we head to outdoor festivals. Kissing as the summer frogs sing a chorus, or partying late into the night: how beautiful!
But summer can be awful, too. Too much beer at a festival and you throw up everywhere, or too much humidity and you die of heatstroke. There's a reason that gun violence goes up when it's hotter: people are pissy and itching for a fight.
There can be a great push-pull here as characters attempt to moderate themselves while also indulging their sense of adventure.
Associations
Positive
Adventure
Childhood
Freedom
Exploration
Warmth
Togetherness
Community spirit
Serendipitous meetings
Happiness
A sense of endlessness (longer daylight hours)
Puppy love
Negative
Long agonizing waits (again, longer daylight hours)
Exhaustion
Overwhelm
Oppression (sociological or environmental)
Excess
Sloth (if characters like to lounge)
Lack of control
Rage
Frustration
Disappointment
Descriptions
Positive
Droning insects
Fireflies (depending on area)
Warmth
Blue skies
Bright green leaves
Active wildlife
Butterflies
Cool drinks
Unexpected cool breezes
Fresh fruit
Whirring fan
Outdoor music
Sunshine
Beautiful sunsets
Negative
Loud, cramped festivals
High humidity
Extreme heat
Dehydration
Glaring sunlight with no shelter
Tornadoes/summer storms
Mosquitos
Broken fan
Sweating
Baking trash (ugh sorry)
Sore joints from the humidity
Spoiled/soggy food
Flat fizzy drinks
Autumn
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Okay, I'll try not to be too biased here, so I'll point out that autumn can be both beautiful and terrible. On one hand, we've got the cooler weather, the gorgeous foliage, and the contentment of harvest time: a job well done, and a time to rest.
Many people feel like this is when they are closest to their past loved ones and can commune with those long gone, which can be a good thing or a bad thing. It's a good time for when someone is putting their demons to rest and moving on.
We can also feel cold, dread, and fear during autumn. The nights are getting longer, and there could be all sorts of scary things in the shadows. They, too, are gearing up for the freezing winter months - and they're hungry.
Associations
Positive
Maturity
Adulthood
Rest
Slowing down
Introspection
Thinning of the veil (Halloween)
Spirituality
Retrospection
Harvest and bounty
Change
Reflection
Negative
Fear
Dread
Decay
Lost opportunities
Dwindling time
Anxiety
Limitations
Closer to the end
Feeling one's age
The unknown
Breaking down
Past coming back to haunt one
Descriptions
Positive
Falling leaves
Brisk wind
Crackling campfires
Warm drinks
Busy animals
Frost sparkling on grass
Seeing your breath in the air
Freshly baked pie
Crisp apples
Decorative pumpkins
Cozy hoodies/cloaks
Mulled wine and spices
Harvested grain
Baked bread
Sudden warm days
Negative
Fog shrouded, isolated roads
Creeping cold
Howling animals
Dark nights
Rotting fruit
Bitter wind through cracks in the house
Cold rain
Spoiled grain
Meager harvest
Insufficient clothing
Dead creatures
Skeletons
Icy mist
Barren trees
Creaking houses
Winter
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Winter gets the short end of the stick when it comes to symbolism. People focus on the horrible things (cold, loss, sadness) without considering the positives: family, togetherness, comfy mittens, warm hot chocolate and presents.
After all, humans have developed our very own symbolism just to cheer the time up; winter celebrations happen all around the world. You've got so many options here, both in terms of themes, activities, and descriptions. What you focus on will determine how your story feels.
Associations
Positive
Togetherness
Community
Family
Resilience
Perserverence
Joy and whimsy
Caring for others
Possibilities
Planning
Companionship (or solitude)
Optimism
Pushing one's limits
Quietude
Introspection
Better days ahead
Negative
Cold
Nature's fury
Helplessness
Poverty (in any form)
Feeling trapped
Unpleasant relatives
Death
Old age
Broken relationships
Barrenness
Struggle
Endings
Sorrow
Lack of empathy
Hatred
Descriptions
Positive
Roaring fires
Soft heavy blankets
Thick socks
Cozy mittens
Jams and jellies
Hot drinks
Presents
Winter decorations
Christmas cookies
Candles
Softly drifting snow
Clear night skies
Conversations in another room
Clinking glasses
Mulled cider
The contrast between chilly room and warm blanket
Dead quiet nights
Negative
Freezing cold
Driving snow
Stuck in big snow drifts
Tense muscles
Dry skin
Running nose
Barren cupboards
Tense conversations with distant relatives
Frozen hands
Harsh wind
Stuffy rooms
Cold floors
Animals scratching at the door
Lack of ventilation
Can't get warm
Shivering
So there are my thoughts on the seasons! Hopefully this sparked something for you.
Now, perhaps, you will consider reading my book (now cheaper than ever!)
9 Years Yearning is a whirlwind look at two men growing up and finding themselves - and each other, wink wink. It features Uileac, an orphan determined to protect his little sister and become the best soldier he can be. However, this is complicated by Orrinir, a blustery young man whose bravado hides a surprisingly sensitive heart. In just under 34k words, they experience the whole range of human emotions - and beat a few people up. Ooh la la.
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If you do decide to read 9 Years Yearning, don't forget to leave a review!
It can even be a bad review if you want. Amazon uses ratings of all shapes and sizes to determine whether a book is worth getting shown to other potential readers.
Lack of reviews = Jeff Bezos breaks my door down with a baseball bat and drags me to the Hell Sphere.
So please, I have dogs that want their snackies. For $2 and a few nice words, YOU can help buy this small child her favorite treat (bully sticks).
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thehopefuljournalist · 1 year ago
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unrelated- what's your favorite news story recently?
Hello, thank you so much for asking!! I've had a hard time because this week was actually full of news stories and I'm working on releasing them all to you guys!
But let me tell you about my favourite one from today :)
As an activist, working within my own country and out especially in climate-related themes, I believe in people-power, fully. I know, of course, that some people have more power and influence than others, but there's no denying that there's strength in numbers.
This recent, huge, protest in New York is such a hopeful turn, I think. I love seeing that I'm not the only one worried, that I'm not alone in my fighting. With numbers, we have a bigger chance of winning over our world leaders, and by doing that, to protect ourselves and our futures.
Well, this is my favourite news story from the past two days.
This past Sunday, 75K climate activists took to New York's streets in a “march to end fossil fuels”
Congresswoman Alexandria Ocasio-Cortez criticized the US continuing to approve fossil fuel projects, something which the Biden administration did earlier this year with the controversial Willow project in Alaska.
“We are all here for one reason: to end fossil fuels around the planet,” Ocasio-Cortez told a rally at the finish of the march, which ended close to the UN headquarters where world leaders will gather this week. “And the way we create urgency is to have people around the world in the streets.”
“The United States continues to be approving a record number of fossil fuel leases and we must send a message, right here today,” adding that despite record profits the support for the fossil fuel industry was “starting to buckle and crack”.
“This is an incredible moment,” said Jean Su of the Center for Biological Diversity, who helped organize the mobilization. “Tens of thousands of people are marching in the streets of New York because they want climate action,"
“This also shows the tremendous grit and fight of the people, especially youth and communities living at the frontlines of fossil fuel violence, to fight back and demand change for the future they have every right to lead,” she said.
The march came during Climate Week, as world leaders gather for this week’s UN general assembly, and a UN climate ambition summit on Wednesday.
On Friday, the national security adviser, Jake Sullivan, said Biden was not currently scheduled to take part in Wednesday’s UN climate summit. Biden has been praised by climate activists for last year passing a historic $369bn climate law but criticized for allowing oil drilling projects and the expansion of gas facilities in the Gulf of Mexico.
A decision for Biden to stay away from the UN climate ambition summit is “unacceptable”, said Su of the Center for Biological Diversity. “The time is now for Biden to lead on the world stage, and show he means it when he calls climate change the existential threat to humanity.”
During the march, the Rev Lennox Yearwood, head of the Hip Hop Caucus, likened today’s climate movement to the US fight for racial justice. 
Youth climate activist Vanessa Nakate, from Uganda, said: “When we say that we want climate justice, we’re not just talking about transitioning to solar panels. We are talking about leaving no one behind when you’re talking about addressing the injustices that come with the climate crisis."
Article published September 17, 2023 - The Gaurdian
Another article, interviewing a young climate activist
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justinspoliticalcorner · 2 months ago
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Mira Lazine at LGBTQ Nation:
A House committee just passed a bill that would forcibly out trans students. It was introduced by Rep. Tim Walberg (R-MI), who previously advocated for Uganda’s gay death law, the Anti-Homosexuality Act.
The bill, H.R. 736, also known as the “PROTECT Kids Act,” would require elementary and middle schools to forcibly out trans kids to their parents if they ask to go by new pronouns or a new name or use the facilities associated with their gender. If schools failed to comply, they would risk losing all federal funding. “As a condition of receiving Federal funds, any elementary school… or school that consists of only middle grades… that receives Federal funds shall be required to obtain parental consent before— (1) changing a minor child’s gender markers, pronouns, or preferred name on any school form; or (2) allowing a child to change the child’s sex-based accommodations, including locker rooms or bathrooms.” The bill was introduced in February of last year and was referred to the Committee on Education and the Workforce. It was voted out of committee on a 22 to 12 vote this week and will now be going to the House floor for a possible vote. H.R. 736 was introduced by Walberg in the House and Sen. Tim Scott (R-SC) in the Senate.
Rep. Tim Walberg (R-MI)’s federal anti-LGBTQ+ forced outing bill HR736 (aka the “PROTECT Kids Act”) would require elementary and middle schools across the US to enact student safety-endangering forced outing policies. The bill passed the Education and the Workforce Committee 22-12, and could be set for a full House vote.
The bill has NOTHING to do with “protecting kids”, but an excuse to harass LGBTQ+ students, especially if they do not have supporting parents.
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tomorrowusa · 10 months ago
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Uganda is Africa's most homophobic country. And the hatred unleashed there by the government and extremist religious groups has led to violence.
A prominent Ugandan LGBTQ+ activist is in a critical condition after he was stabbed on his way to work on Wednesday by unknown assailants on a motorbike.
Steven Kabuye, 25, suffered knife wounds and was left for dead in the assault on the outskirts of the capital Kampala before being found by local residents, police said. Human rights defenders have been warning about the risk of attacks on members of the LGBTQ+ community after Uganda last year adopted what is considered one of the harshest anti-gay laws in the world. Kabuye told detectives investigating the incident that he had been receiving death threats, according to a statement issued by police spokesperson Patrick Onyango. “According to Mr Kabuye, two unidentified individuals on a motorcycle, wearing helmets, approached him. The passenger jumped off and attacked him, specifically targeting his neck with a knife,” Onyango said. “Kabuye managed to shield his neck with his right arm, resulting in a stab wound to his hand. Despite attempting to flee, the assailants chased and stabbed him in the stomach and left him for dead,” he said, adding that local residents had found him and taken him to a medical clinic.
You can in certain instances get the death penalty for being gay in Uganda. The assailants probably felt it was their duty to try to murder Steven Kabuye.
In May last year, Uganda adopted anti-gay legislation containing provisions making “aggravated homosexuality” a potentially capital offence and setting out penalties for consensual same-sex relations of up to life in prison. Homosexuality has long been illegal in Uganda under a colonial-era law criminalising sexual activity “against the order of nature”, with life imprisonment possible for a conviction. The new law added further offences and punishments. Kabuye had posted on X that he was deeply concerned about the consequences of Uganda’s Anti-Homosexuality Act 2023. “This law violates basic human rights and sets a dangerous precedent for discrimination and persecution against the LGBTQ+ community. Let us stand together in solidarity and fight against bigotry and hate,” he wrote.
Uganda is a good place to avoid even if locals just think you are LGBTQ+.
Uganda's homophobic President Yoweri Museveni seized power in January of 1986. That's so long ago that the Space Shuttle Challenger was still intact when he began his reign as de facto president for life. According to the journal Foreign Policy, Museveni may be looking to turn Uganda into a North Korea-style monarchy without crowns.
Politics in Uganda has become a parable of dynastic decay. For 37 years, President Yoweri Museveni has ruled with a supporting cast of relatives, army officers, and hangers-on. They see themselves as the only ones capable of running the country—and have profited handsomely from doing so. Museveni has twice had the constitution rewritten to remove limits on his rule. But he is now 78, and he cannot rewrite biology. Enter his 49-year-old son, Muhoozi Kainerugaba: a hard-drinking, trash-tweeting soldier who considers himself “the most handsome General on earth.” After a rapid promotion through the army ranks, Kainerugaba says he wants to run for president at the next election in 2026.
Uganda is part of the corrupt Axis of Homophobia which includes Russia and Iran. It deserves the same opprobrium which is directed at those decrepit régimes.
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fishcowwrites · 1 month ago
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Four Corners - Chapter Two
Newsies x The Maze Runner x The Outsiders x The Book of Mormon
911 words cross posted on ao3 under cut
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It was like nothing they had ever seen. And judging from the noise earlier that morning, it was like nothing that any of the other groups had seen either. The lodging house, the homestead, the district 9 headquarters, and the Curtis family home had all fused together, creating a square abomination of architecture. The huge building was placed on a huge square of grass that seemed to spread infinitely outwards. A large lake sat at the southern corner, while grove of trees adorned the northern tip. The eastern point was crowned with mountains and the western point dipped down into a valley, all of this with no end in sight.
Introductions happened quickly, with each group designating a leader. Jack was used to leading the newsies and stepped up quickly, though not without exchanging a few glances with Davey and a taking punch from Spot.
Thomas was new to the whole “leader” thing, but Minho practically shoved him forward as Newt nodded in assurance, pursing his lips. He tried to claim that Newt would be better, or maybe Minho, but the rest of the Gladers wouldn’t hear any of it.
There wasn’t really any discussion amongst the greasers as Dally moved forward. He didn’t even say much, just muttered his name as he looked around the room at all the unfamiliar faces.
Conner had been the district leader back in Uganda, but now he wasn’t so sure of his position. Kevin had really taken charge after the whole “Book of Arnold” disaster, but with Poptarts beaming at him, he couldn’t really say no.
The four of them moved to a side room to discuss their current situation, where it became quickly apparent that none of them knew what to do. It wasn’t like this was something that happened on a daily basis. Running out of snacks in the mission kitchen or getting a D on a math quiz was nothing compared to teleportation, and apparently, time travel.
Connor could tell something was off in the way everyone spoke. It wasn’t just accents or something regional, no, this was a difference not from distance. Tentatively, he spoke up.
“I know this might sound really stupid, or really weird, but what year do you think it?” Instantly, three pairs of eyes locked onto him. Hesitantly, Jack scoffed.
“What kinda question is that? 1899.” Oh God. The whole situation had thrown Connor so off balance that he barely noticed his own use of the Lord’s name.
“That’s-no, that’s not right. It’s 2011.” Connor shook his head, starting to panic. He wished Kevin were here. Kevin always knew how to calm him down. He took deep breaths, trying to remember what Kevin had taught him.
“Are you both insane? It’s 1967. Thomas, back me up here.” Dally was looking at Connor and Jack like they had turned into bananas with three eyes. Thomas stayed silent, his brow furrowed as he looked back and forth between them all. Finally, he spoke.
“I don’t know, I guess. We barely have a concept of time in the maze. Any of you could be right.” Jack tilted his head, not quite following.
“But what about before you was in this-this maze thing? You wasn’t born there, right?” Dally and Connor both murmured their assent, looking at Thomas expectantly. He had fallen silent again, biting his lip as he frowned.
“No. There was a group of them, and they all woke up in the maze one day, no memories. The rest came up one by one. None of us know why, or how, or anything really. Just that we had to survive and escape.” He seemed so lost in thought that Connor felt he needed to say something just to break the tension. Clearing his throat awkwardly, he spoke up.
“Speaking of survival, how are we supposed to do that? What do we do about food?” Connor was no stranger to the creeping fear of hunger. When they were still in the church, there were times when pests got into the food, or a crisis came up long before their monthly shipments. And after they got excommunicated, their little amount of money got stretched tighter than they ever thought it could while they worked towards getting back to America. But they always had the villagers helping them. Here, wherever they were, they had nothing.
Connor must have zoned out, because the others were all staring at him as if expecting him to say something. “What? Sorry, I just-” His words died in his throat as he crumpled under the weight of Dally’s gaze.
“He-” Dally cocked his head at Thomas “Just asked how we should tell them our plan. Separate to our own guys, or all together. We wanted your input, but it seems you’ve been lost in that pretty little head of yours.”
“NO!” Connor spluttered. “I mean, no, I was listening, I just, that sounds good! Maybe all together, to, y’know, show unity, or, uh, like show we’re working together! And the plan? Oh, the plan is great. Great plan. Love it. I think it’s-” Jack held up his hand to stop Connor’s rambling.
“Ok. Ok. We should get back to the group before Spot starts a fight with someone. Ready?” Thomas nodded, and after a moment, Dally did too. All eyes were on Connor again, who was trying not to hyperventilate. He took a deep breath, his nails digging into the old scars on his hands.
“Ready.”
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once again brought to you by Way Down We Go by KALEO and also Austin McKenzie and Sean Grandillo's cover of Thinkin Bout You cus its really good
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rjzimmerman · 2 months ago
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Excerpt from this story from Inside Climate News:
Amid the corporate events pervading New York’s “Climate Week,” an international people’s tribunal held an emotional hearing that spotlighted the ecosystems and people living in the shadow of fossil fuel projects. 
Representatives from communities around the world, scientists and advocates told stories of human and nonhuman forced displacement, degraded heath, ruined economies and lost histories to the International Tribunal on the Rights of Nature on Sunday. 
In India, coal mines are degrading the habitat of endangered elephants sacred to Adivasi Indigenous people. In Louisiana, petrochemical facilities are being built on sacred grave sites. In East Africa, construction of a new oil pipeline is displacing communities and slicing through the homes of giraffes, lions and hippopotamuses. And in Peru, communities that have endured decades of crude oil production and more than 1,000 oil spills are facing down installation of a new refinery and expanding operations.
The testimonies, sweeping in both their global reach and in the harms alleged, were gathered to create a repository of evidence linking the “fossil fuel era” to violations of humans’ and nature’s rights. 
The tribunal, now in its sixth session since 2014, is designed to probe alleged violations of the 2010 Universal Declaration on the Rights of Mother Earth, which recognizes nature as a living being with inherent rights, including the rights to exist and evolve.  
“Just as human beings have human rights, all other beings also have rights which are specific to their species,” the nonbinding declaration says. The declaration was written during a 2010 people’s conference in Cochabamba, Bolivia, following a disappointing United Nations climate summit in Copenhagen a year earlier.
The tribunal is part of the growing “rights of nature” movement, which since 2006 has also created binding laws and judicial precedent recognizing nature’s rights. Today, more than a dozen countries have such laws on the books, including Ecuador, Panama, Spain, New Zealand, Brazil, Colombia and Uganda. But few countries have taken steps to enforce the laws. 
The advocacy group Global Alliance for the Rights of Nature created the tribunal to showcase how a legal system recognizing nature’s rights might work. Past hearings have taken on cases like the Deepwater Horizon Oil Spill, lithium mining in Chile’s Atacama Desert and the impact of free trade agreements on the environment. In each case, “defendant” companies and governments are invited to participate but generally decline to do so. Though the rulings are nonbinding, the tribunal’s website says its work pressures governments by drawing international attention to issues. 
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everalii · 2 months ago
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Random Hogwarts Legacy Girls Headcannons
Now the girls!
I'll be doing a headcannon post for my MC, Claire Beckett, but this is only for the NPC girls.
♡ Poppy Sweeting ♡
• Hates people? Of course, unless they're Ominis Gaunt. She was head over heels for him since she saw the boy sit on the Sorting Hat stool in the 1st year. She was completely overwhelmed when he begun courting her;
• Poppy at first wanted to become a researcher like her grandmother, but after fighting poachers with MC, decided she'd be an auror, and her main goal was to end every poaching camp possible;
• Her last name may be Sweeting, but she enjoys salty food. Shepherds pie is her favourite meal;
• She considers MC her best friend, and eventually, Natsai as well. You'd always see the trio together;
• Was haunted in terrible nightmares by the dragon she saved with MC. In her dreams, she failed to save her. Ominis was the one to comfort her, and he commissioned a necklace with a dragon pendant for her, the pendantwas charmed to calm her dreams;
• Transfiguration was her second favourite class, however, she'd cry if the task was to transfigure some creature into and inanimate object;
• She's passionate Cancer, born in june 27th.
◇ Natsai Onai ◇
• Her biggest dream is to return to Uganda, where she can roam free as a gazelle;
• But, if she was to stay in Britain, she would love to become and auror with Poppy and MC. They would ravage poachers and ashwinders;
• Her best friend is Anne, and she was the only one to know about her animagi form until MC and later, Poppy. The proximity with Anne also made her close to Sebastian. Garreth was also her best friend, and she suspected he fancies Anne;
• Is the seeker of the Gryffindor quidditch team. She caught the snitch three times already! Her broom was once jinxed so she wouldn't be able to catch it, but she did it anyway;
• When in Hogwarts, she corresponded with her friends in Uagadou, and they found extremely weird to wield magic with a wand. She has grown fond of her wand, but every time she could, she'd cast wandless magic just to impress people;
• She got very self conscious of her colour and hair texture when she got in Britain, but Anne helped her to overcome her insecurities;
• Born in January 6th, she's a strong capricorn.
♤ Anne Sallow ♤
• She was actually the troublemaker of the twins. Ominis had to put up with 2 idiots sharing a single braincell;
• Her favourite class was Herbology, she would stay for hours in the greenhouse with professor Garlick chatting and tending the gardens;
• Once, Cressida spread a rumor about Anne and Ominis being involved romantically during their 4th year. Anne and Natty broke into the restricted section so she could get a book on hexes. She hexed Cressida's hair to turn into a green goo. Anne was in detention for a good 3 weeks, but the Gryffindor never lied about her again;
• Anne is a legilimens, and Sebastian is a natural occlumens. Despite being difficult, Sebastian doesn't lock is thoughts with much efficiency so she can read a few things. Usually is his perverted thoughts of MC, which Anne is disgusted about;
• She was unsure about MC at first, thinking she stole her place in Hogwarts, as everyone of her friends also became friends with MC. But they eventually got along, when she realized her brothers feelings for the new girl;
• Loves to cook and bake. When the pain attacks were sparce, she would bake for her uncle to make him calmer. It helped, and he was way less stressed;
• An her twin, she's a Sagittarius, born in december 14th. Also, she's was born first.
♤ Imelda Reyes ♤
• Her family comes from Spain, and when nervous, she shouts in spanish. Due to her spanish blood, she was supposed to be admitted to Beauxbaton, but much to her British mothers satisfaction, she received a Hogwarts acceptance letter;
• Her older brother plays in the Spanish National quidditch team, however, Imelda's wish is to play in the British team so she can beat him;
• Couldnt sstand Everett, only the mention of his name makes the blood boil in her veins. Hes always teasing her and she was always fighting him. During their 7th year, she realized she'd fallen for him and it haunted her for good. They begun courting shortly after graduation;
• Secretly loves romance novels, and spent 7 years day dreaming about the one she would marry;
• Also dances very well. Somehow, she managed to teach flamenco to Garreth, and they dance at parties and gatherings;
• Is very lightweight when it comes to alcohol, a cup of butterbeer makes her head dizzy and rambling non-sense.
• A very hot heated Virgo, born in september 8th
Any girl you want headcannons? Tell me in the comments.
Also, my own birthday was mentioned, guess which girl I gave it to.
Love y'all
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bopinion · 3 months ago
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2024 / 33
Aperçu of the week
“All we have to do is call our opponent a communist or a socialist or someone who will destroy our country.”
(Donald Trump. We'll see about that...)
Bad News of the Week
Since the end of the coronavirus pandemic - although there hasn't actually been one - I've been waiting for its successor in a slightly anxious mood. Another rapidly infecting virus that spreads worldwide, is potentially deadly and, above all, restricts all our lives again. Now it's here: Mpox. For the first time since Corona, the WHO (World Health Organization of the United Nations) has declared the highest alert level, a “public health emergency of international concern”. Because of the virus that was previously called “Monkey Pox”. Discovered in Congo at the end of 2023, it has now also broken out in Uganda, Rwanda, Burundi and Kenya.
The initial figures spoke of 14,000 suspected cases. Based on the usual 50% rate and the reported 500 deaths, this means that one in twelve people who become infected will die. That's a lot. So it's certainly a virus that should be taken seriously. One day later, it was reported that the first case in Europe had emerged in Sweden. Then the first three in Asia in Pakistan. It's the usual pattern: on the one hand, every infectious disease spreads faster and more uncontrollably in times of international travel. On the other hand, specific cases are only discovered when they are specifically sought or tested for. So the numbers will now quickly go through the roof. Because the spread is already more advanced than we know.
What will happen now? What will the states do? How will society react this time? And above all: what have we learned? There is a lot of talk in Germany about the need to come to terms with everything that has happened around COVID. Also to learn from the mistakes. There is a lot of need for clarification - for example with regard to the procurement of masks, the closure of schools, compulsory vaccination, curfews and unequal treatment in the retail sector. And what has happened since (drum roll please!): Nothing. What applies to politics also applies in private life. Some friends turned out to be conspiracy theorists, others were law and order hardliners, most were simply irritated and unsettled. There were even rifts right through families. Rifts that still exist.
And now we could all be facing the same situation, just as ill-prepared. And if Mpox doesn't develop into a pandemic, perhaps swine fever will spread to humans. Or bird flu. Or something else entirely, be it from the South American jungle or from the secret laboratory of some deep state. Or a revenant from the past spreads again - cholera still exists after all and first cases of polio are reported from Gaza. No, I'm not panicking. But I do have one or two worries. After all, humanity has shown itself more than once to be incapable of learning from the past. I would love to be wrong about that.
Good News of the Week
Venezuela is not giving up. It is wonderful to see how the people are fighting for democracy, no longer wanting to put up with the corruption of their “elites” and finally wanting to have a perspective worth living in. Just under a month ago, elections were held in the Latin American country, which could actually live in prosperity and peace but is suffering from dramatic economic decline, inflation and poverty since years. Or as investigative journalist Sebastiana Barráez says in the news magazine Der Spiegel: “Maduro has couped!”
Initially, the state electoral authority declared President Nicolás Maduro Moro, who has been clinging to power since 2013, the winner without providing any evidence - as is actually required by the constitution. The opposition has now had access to more than 80 percent of the printed protocols of the individual polling stations and has made them public. According to these, their candidate Edmundo González won with around 67 percent of the vote - compared to 30 percent for the incumbent head of government. So did Maduro commit electoral fraud? It looks like it.
The United Nations and the Carter Center had sent election observers to Venezuela. They have now criticized the election authority's actions and declared that the official result was not achieved democratically. The panel of experts speaks of an “unprecedented process in recent electoral history”. No wonder that most Latin American countries as well as the USA and Europe did not recognize the “official result”. And Maduro? He doesn't give a damn. The despot has further intensified the repression against the population with the help of the military, the National Guard and other state organs loyal to him. According to the independent rights organization Foro Penal, over 2,000 people have been arrested since the election. These include opposition politicians. And journalists. That speaks a clear language.
According to a report in the Wall Street Journal, the US government has now offered Maduro and close associates of the regime an amnesty if they relinquish power. I wish the Venezuelans would keep up the pressure. And the international stage too. Until Madura and his clan really abdicate. Because then the country, which has already been abandoned by 20% of its population in recent years, could return to better times. In a survey conducted by the Gallup polling institute in December 2012, the country's inhabitants were among the happiest people on earth. It would be nice if this vague memory could become reality again.
Personal happy moment of the week
“Your application for an Electronic Travel Authorization (eTA) has been approved. You are now authorized to travel to Canada by air.” Nothing more to add here. Taking off this sunday. Boy am I excited...
I couldn't care less...
...about the discussion that Germany “only” came 10th in the medal table at the Summer Olympics in Paris - behind hosts France and Great Britain, even though their populations are smaller. “What does it take for more medals?” asks the Tagesschau news channel. That is of little interest to me. Much more important is the charisma of athletes as figures of identification for a nation, the role model function for children, the motivation to surpass oneself. After all, it's not for nothing that the Olympic motto is “Taking part is everything”. In that sense, Eddie the Eagle really did fly.
It's fine with me...
...that the Democrats' party conference is now turning into a coronation mass. Because the most important decisions have been made: Presidential candidate and his (better in this case “her”) running mate. Normally, I would now say that political program content should not be completely secondary. But I don't care about that at the moment. The main thing is momentum. The main thing is optimism. The main thing is not to go back. The main thing is that Donald Jessica Trump doesn't triumph in November. Harris Walz!
As I write this...
...we're trying to catch a mouse. Apparently it was raining too hard outside and it wanted to get out into the dry. Now she's hiding behind a bookshelf and is afraid of us - even though we want to rescue her and set her free. Update: we've got her and she's fine. Second update: there seems to be another one...
Post Scriptum
It's good when someone doesn't look away but points. Even if it's about Israel committing an injustice. After all, you are then almost reflexively vilified as an Anti-Semite. In this respect, I am pleased that the European Union is showing more and more backbone in this regard. In this case, I am not referring to the maltreated Gaza Strip, but to the West Bank, where the Palestinian population is suffering more and more from brutal attacks by militant Israeli settlers - who can be sure of the backing of Benjamin Netanyahu's increasingly right-wing extremist government.
Once again, there have been attacks by extremist Israeli settlers on the population of the West Bank. And now EU foreign policy chief Josep Borrell has had enough. He will “present a proposal for EU sanctions against the supporters of the violent settlers, including some members of the Israeli government”. Including the government! That's a bombshell. I very much hope that he finds the necessary support for this. Because this massive problem is currently all too easily overlooked in the great shadow of Gaza.
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aroaceloverofgarlicbread · 4 months ago
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name every country
Ok here’s a list of every country that I totally wrote all by myself (Totally not copy pasted don’t worry about it):
Afghanistan, Albania, Algeria, Andorra, Angola, Antigua and Barbuda, Argentina, Armenia, Australia, Austria, Azerbaijan, Bahamas, Bahrain, Bangladesh, Barbados, Belarus, Belgium, Belize, Benin, Bhutan, Bolivia, Bosnia and Herzegovina, Botswana, Brazil, Brunei, Bulgaria, Burkina Faso, Burundi, Cabo Verde, Cambodia, Cameroon, Canada, Central African Republic, Chad, Chile, China, Colombia, Comoros, Costa Rica, Côte d’Ivoire, Croatia, Cuba, Cyprus, Czech Republic, Democratic Republic of The Congo, Denmark (We are coming for you Denmark. We will win. Do not try to fight back), Djibouti, Dominica, Dominican Republic, East Timor, Ecuador, Egypt, El Salvador, Equatorial Guinea, Eritrea, Estonia, Eswatini, Ethiopia, Fiji, Finland, France, Gabon, Georgia, Germany, Ghana, Greece, Grenada, Guatemala, Guinea, Guinea-Bissau, Guyana, Haiti, Honduras, Hungary, Iceland, India, Indonesia, Iran, Iraq, Ireland, Ironland, Israel, Italy, Jamaica, Japan, Jordan, Kazakhstan, Kenya, Kiribati, Kosovo, Kuwait, Kyrgyzstan, Laos, Latvia, Lebanon, Legoland, Lesotho, Liberia, Libya, Liechtenstein, Lithuania, Luxembourg, Madagascar, Malawi, Malaysia, Maldives, Mali, Malta, Marshall Islands, Mauritania, Mauritius, Mexico, Micronesia, Moldova, Monaco, Mongolia, Montenegro, Morocco, Mozambique, Myanmar, Namibia, Nauru, Nepal, Netherlands, New Zealand, Nicaragua, Niger, Nigeria,North Korea, North Macedonia, Norway, Oman, Pakistan, Palau, Palestine, Panama, Papua New Guinea, Paraguay, Peru, Philippines, Poland, Portugal, Qatar, Republic of The Congo, Romania, Russia, Rwanda, Saint Kitts and Nevis, Saint Lucia, Saint Vincent and the Grenadines, Samoa, Sanlow, San Marino, Sao Tome and Principe, Saudi Arabia, Senegal, Serbia, Seychelles, Sierra Leone, Singapore, Slovakia, Slovenia, Solomon Islands, Somalia, South Africa, South Korea, South Sudan, Spain, Sri Lanka, Sudan, Suriname, Sweden, Switzerland, Syria, Taiwan, Tajikistan, Tanzania, Thailand, The Fire Nation, The Gambia, Togo, Tonga, Trinidad and Tobago, Tunisia, Turkey, Turkmenistan, Tuvalu, Uganda, Ukraine, United Arab Emirates, United Kingdom, United States, Uruguay, Uzbekistan, Vanuatu, Vatican City, Venezuela, Vietnam, Yemen, Zambia, Zimbabwe
Note: This is not technically every country because a lot of different countries have different definitions of what a country is and I’m not including every single micro nation ever created (I may or may not have included one though, as well as a few other Easter eggs which ones may it be?)
Also I realize this will take up a lot of space and probably be annoying so uh, sorry about that anyone else who’s reading this. Blame anon. We should all blame anon for everything bad that ever happens in our lives from now on. (Don’t ask why I wrote this last part I just want there to be some content worth anything in this post)
Also just so this is something about aspec which is this blogs main purpose: Aroace people exist. There you go
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kneelbeforezod · 1 year ago
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Just gonna go ahead and say it. Since so many people are missing the nuance.
The reason so many Western powers do nothing to stop Israel is because it means admitting their own antisemitism was a driving force behind Israel's very creation.
Literally every country/kingdom/empire in which the Jewish people have lived, throughout history, has villified them and tried to kill them, cast them out or some combination of both. The very reason there are Jewish people across Europe is because the Roman empire found them to be too hard to manage in large numbers as they did not respect Roman authority. So the Diaspora or "dispersement" happened repeatedly and the middle eastern Jewish population was spread across Europe as far west as the UK and as far east as Russia.
Antisemitism was running rampant in the UK, the US and many other places before Hitler came along. The very reason that there is a stereotype about Jewish bankers, is because for a very long time (particularly in England) they weren't allowed to work most jobs in most fields. Their options were limited, and lending (not borrowing) money is not allowed by the Roman Catholic Church, which ruled over England from the 6th century to 1534. A thousand years of being a nation's only bankers is going to make you rich, but when times got hard economically, the British began to default on their debts and the stereotype of the "greedy jew" was born from this.
Antisemitism is thousands of years old and the aforementioned countries and others were looking for a way to deal with this "problem" and the idea of giving them their own country to go live in. So they leave yours, was presented and initially rejected, until Hitler came along. What the Nazis did allowed for this idea to move forward, now with the entire world feeling sympathetic to the horrors the Jewish people endured under their occupation.
Uganda was actually the original site planned in 1905, but their government and WHITE settlers their fought tooth and nail until another site was chosen, Palestine.
People seem to think Israel has always existed, but that is simply not the case. The word Palestine derives from Philistia, the name given by Greek writers to the land of the Philistines who in the 12th century BCE occupied a small pocket of land on the southern coast, between modern Tel-Aviv-Yafo and Gaza. The name was revived by the Romans in the 2nd century CE in “Syria Palaestina,” designating the southern portion of the province of Syria, and made its way thence into Arabic, where it has been used to describe the region at least since the early Islamic era. The Romans literally wiped Judea off the map, reduced it to rubble, before renaming it, and it stayed that way for the next 400 years.
Around 30% of the Palestinian population was already Jewish and living in relative peace before 1948. They could've easily increased their numbers without drawing new borders, but the Jewish lead British government (the Rothschilds and others already had their hands in everyone's pockets at this point) made it clear in 1917 with the Balfour declaration, that they intended to take Palestine from the Ottoman empire during WW1, and designate it the Jewish homeland. Actually, as soon as the war kicked off, British War Cabinet member and zionist Herbert Samuel proposed the government express support for zionist ambitions in order to gain more Jewish support (money and soldiers) for the ongoing world war. This effort continued through to WW2, finally gaining global support upon the world's realization of Hitler's atrocities.
This situation is anything but black and white.
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justforbooks · 9 months ago
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It did not seem like a good thing when a precious consignment of human tumour samples on its way from Kampala, Uganda, to Heathrow was diverted to Manchester. When the samples finally arrived at the Middlesex hospital in London, they were swimming in murky fluid in their vials as though they had been infected with bacteria.
But when the pathologist Anthony Epstein looked at the fluid under the microscope he saw no bacteria, just individual cells that had been shaken loose from the tumours. And that was just what he needed in order to search for elusive virus particles and test his hunch that they were causing cancer.
In the early 1960s Epstein, who has died aged 102, had heard a lecture by Denis Burkitt, an Irish surgeon working in Kampala, that described strange tumours (now known as Burkitt lymphoma) growing around the jaws of children in equatorial Africa.
Intriguingly, the geographical distribution of the condition seemed to depend on temperature and rainfall, suggesting a biological cause. Epstein, who had been working with viruses that cause cancer in chickens, immediately suspected a virus might be involved, perhaps in association with another tropical disease such as malaria.
Epstein began to collaborate with Burkitt, who supplied him with tumours from children he had treated. But Epstein’s efforts to grow pieces of tumour in the laboratory and isolate a virus had all been unsuccessful until the dissociated cells arrived.
With his graduate student Yvonne Barr, he then decided to look at cultures of these cells in an electron microscope, a powerful instrument that had only recently become available in his lab.
The very first image showed a tell-tale outline that looked like one of the family of herpes viruses. It turned out to be a previously undescribed member of that family, and was given the name Epstein-Barr virus. In 1964, Epstein, Barr and Epstein’s research assistant, Bert Achong, published the first evidence that cancer in humans could be caused by a virus – to be greeted by widespread scepticism even though they went on to demonstrate that EB virus caused tumours in monkeys.
Thanks to samples supplied by Epstein, in 1970 Werner and Gertrude Henle at the Children’s hospital in Philadelphia discovered that EB virus also caused glandular fever. That made it possible to design a test for antibodies to the virus in order to confirm a diagnosis. EB virus turned out to be very common, infecting most children in early life, though it usually causes glandular fever only in older teenagers and young adults. As well as causing Burkitt lymphoma in endemic areas in Africa and Papua New Guinea, it is also associated with a cancer of the nose and throat that is the most common cancer of men in south China, as well as cancers in people whose immune systems have been compromised, such as those infected with HIV.
More recent research suggests that EB virus might also be involved in some cases of multiple sclerosis, and that people who have previously had glandular fever are more susceptible to severe Covid-19.
After the discovery, Epstein and others devoted time and effort to trying to find out under what circumstances EB virus causes cancer. The relationship between the virus, other diseases, human genetics and cancer is complex, and it took decades before the medical community could accept the EB virus as a cause with confidence.
Not until 1997 did the International Agency for Research on Cancer class it as a Group 1 carcinogen, formally acknowledging its role in a variety of cancers.
The discovery of EB virus opened up a whole new field of research into cancer-causing viruses. It also raised the exciting possibility of preventing cancers through vaccination, an advance that has now been achieved in the case of human papilloma virus, which causes cervical cancer, and hepatitis B virus, which causes liver cancer.
By the time of his retirement in 1985, Epstein’s research group at the University of Bristol had developed a candidate vaccine that protected monkeys infected with EB virus against tumours, but neither it nor any other candidate has yet been successfully developed for human use.
Epstein was born in London, one of three children of Olga (nee Oppenheimer) and Mortimer Epstein. Mortimer was a writer and translator who edited The Statesman’s Yearbook for Macmillan from 1924 until his death in 1946. Olga was involved with charitable work in the Jewish community. Anthony attended St Paul’s school in west London, where the biology teacher Sidney Pask encouraged boys to go far beyond the syllabus and whose pupils also included Robert Winston and Jonathan Miller.
Epstein won a place to study medicine at Trinity College, Cambridge. He moved to Middlesex hospital medical school in wartime London to complete his training, before doing his national service in India with the Royal Army Medical Corps. He returned to work at the Middlesex hospital as assistant pathologist, conducting his own research. Thinking electron microscopy might be useful in his studies of cancer-causing viruses in chickens, he spent some time learning the new technique at the Rockefeller Institute in New York (now Rockefeller University). Not long afterwards he attended Burkitt’s lecture and began the serendipitous route to his discovery.
In 1968 he was appointed professor and head of the department of pathology at the University of Bristol, where he remained until his retirement. He moved to Oxford as a fellow of Wolfson College in 1986, becoming an honorary fellow in 2001.
An exemplary scientific good citizen, he served as foreign secretary and vice-president of the Royal Society, and sat on boards and councils for numerous national and international research organisations, including as a special representative of the director general of Unesco; he was also a patron of Humanists UK. Among his many prizes and honorary degrees, he received the international Gairdner award for biomedical research in 1988. He was appointed CBE in 1985 and knighted in 1991.
“It was a series of accidents, really,” he said of his discovery in a conversation with Burkitt they recorded for Oxford Brookes University’s oral history archive in 1991. “Lucky quirks.” Burkitt immediately responded with Louis Pasteur’s aphorism: “Chance favours the prepared mind.”
Epstein was a deeply cultured man who retained a lively interest in many subjects – particularly oriental rugs, Tibet and amphibians – until the end of his life.
He is survived by his partner, Kate Ward, by his children Susan, Simon and Michael, from his marriage to Lisbeth Knight, from whom he was separated in 1965, and who died in 2015, and by two grandchildren and two great-grandchildren.
🔔Michael Anthony Epstein, pathologist, born 18 May 1921; died 6 February 2024
Daily inspiration. Discover more photos at Just for Books…?
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pbaintthetb · 8 months ago
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Lol watched Book of Mormon (and hoo boy possibly actually one of my faves I've watched on stage. Plot is average at best but the goddamn choreo and the lights- the act 1 finale? I digress) thoughts
You can never go home again, or more accurately, You can never go to Orlando again. Anyway Price probably needs a few years to resort his head and life before he can go to Orlando and appreciate it because currently I don't think he can seperate what he wants (needs) Orlando to be from what Orlando actually is...
Orlando and Salt Lake City are the same in the sense that neither of them actually exist and they're metaphors (ignoring the fact that they do, both exist). Both Nabalungi and Price songs about their favourite fictional (real) real (fictional) place are kinda tragic because it reveals the things they view about the world as fact. Hence why this place is so special. Yes comparing Price's pretty first world problems with Nabalung's concerns is a bit of a stretch but also it kind is the same thematically.
I do hope Nabalungi can get what she wants from Salt Lake City though, although not necessarily in Salt Lake city idc.
The vibe I had in the interval was that it was possible out of district 9 Price is the only one to have actually read the Book of Mormon, cover to cover. Cunningham explictly hasn't, the conversation about "latter days" made me wonder if the other mormons only kinda read it which-
leads onto my thinking that like Price's relationship with Mormonism is, in many ways, more academic/clinical. Like he's got that kind of obsession with religion that I personally associate with people who don't actually believe but either A. really want to or B. really want to disprove it. Price is firmly in A, but yeah like I feel like Price needs Mormonism to be real where he is in the plot (Orlando. If mormonism is real he can go back to Orlando. And it's worth it.) But he doesn't necessarily actually have that spark of genuine belief the other District 9 elders have ya get me? Like he knows it back to front he knows the logic, adn in the coffee scene talks about how a lot of it has always seemed nonsensical and incoherent to him. It's a set of rules and guidelines but idk if Price actually has like core real belief/faith.
When those extra rows of lights came down for Man Up near the end of act 1? Oh yeah you bet we were all in for a fantastic time then, you know good stuff is gonna happen
The lighting in Sal Tlay Ka Siti was beautiful, like I mean the actress's performance and voice were great too, but the lighting really sold the like kinda hopeful tragic nature of the song. She's so happy most of the time but that song, ugh, the tree branch gobos, the visible beams, the colour KSJDFJS:LKDF
Lol disco ball.
The set? It's so detailed? And they get it up so fast? LIke I know they drop blacks in "You and me (but Mostly me)" so it's more than the black out, but STILL?
Again, how do they get the waistcoats on so bloody fast in "Turn it off"??? (I do actually have theories about this but that's not the point, it's stilll so cool)
Maybe this is just the run i watched, but like the Mormons, other than being dressed the same are all roughly the same height (except Cunningham) so their numbers are so extra cool because they really do kinda blend and move as one unit and it's so cool to watch. Especially Hello and Two by Two where they all have black ties.
Did they just start a new cult at the end? Curious what most of the mormons are gonna do when they leave Uganda. Also curious if their parents got an angry phone call from the mission president and are just like.... why aren't they home yet???
BFN is an elder now? Okay... not gonna touch that and how that happened
Nabalungi's dad is fucking hilarious omg his delivery this guy
The only song I'd heard was "You and me (But mostly me)" but I had been told of the spooky mormon hell song. The latter slapped. Did not have Atilla the Hun playing flute on my bingo card that day.
^I loved the blacks coming in from all sides to trap Cunningham out of "You and Me (But mostly Me)" and leave Price as the star also like I knew the song but teh first "but mostly me" cracked me up
One of the incorrect names Cunningham called Nabalungi was "Nigel Farage" lol. Couldn't hear much of the dialogue after that.
About the incorrect name, Nabalungi has the patience of a saint for sure.
Oh during teh play i couldn't watch half of it because I was too busy watching the district 9 elders, but mostly Price reacting to it. It was hilarious. Price looked so fucking happy but like he was trying to hide it and was clapping Cunningham on the shoulder at one point.
As a musical, it's incredible, and it properly contextualises a few things people have said about it and how long it's been running. By "as a musical" I mean the general production of it n shit. The plot is pretty average, the songs have funny lyrics but a lot of the numbers probably won't hold up so well on sound track for me personally- but when you're watching it??? oh yeah. Oh yeahhh.
Oh, the pipes on the guy playing Cunningham, man. MAN.
You can never go to Orlando again.
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hannahlikeso741 · 1 year ago
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Some Amit Thakkar Headcanons
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Since Amit is getting some much appreciated love, I decided to share some headcanons about him. Please note I really tried to research as much as I could about India, looking up as much as I could and talking to some of my colleagues who come from varying parts of India, but if I do get some things wrong, please let me know!
He is Gujarati ( Solely based on the surname Thakkar, which is commonly found in the Gujarat state in India)
Amit Thakkar is not his full name ( If we are following the naming system of the Gujarati, it would be his given name, his father's name and his surname in that order. We are missing his father's name.)
He's an Aries ( Again, if we are following the Gurajati naming traditions, his given name, Amit would respond to his Rashi, the Indian Horoscope. Amit responds to the sign Mesha, which Aries is the equivalent)
His family is wealthy and highly educated, and were able to send him to Hogwarts due to their ties to the British Raj. (New telescope aside, a clue lies within the surname. Thakkar is also a common surname found among the Lohana 'Jati' people of Western India where Gujarat is, are famed for being traders. Some of the Lohanas who manage to get an education worked for the British Raj. It is a long history, but this is as best as I can sum it up.)
He is shaken from his first adventure, but secretly he wants more. (Again, we are going back to the Thakkar surname, where it is said they are from the Kshatriya caste which is tied to warrior aristocracy. I like to believe he still got some of that in him, otherwise he wouldn't willingly enter a goblin mine)
He loves astrology as it is closely tied to his Hindu religion. (Thakkar as a surname is closely tied to Hinduism, where astrology is found under the Jyotisha, one of the six auxiliary disciplines of Hinduism, mainly used for time keeping.)
He has family in Colonial India and Africa. (Again back to the Thakkar surname, there were many Thakkars who migrated to the British African colonies like Uganda for example)
He is a polygot. (Ok this might be a bit of a stretch, but I'm just basing it around his family being traders and highly educated. India has plenty of languages, so it wouldn't surprise me if Amit had to learn Hindi, Gujarati, and English to get by, yet he still has time to learn Gobbledegook.)
Well that is all I got for now. Please let me know if there are things to add!
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anonymousewrites · 1 year ago
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A Study of the Heart and Brain (Book 2) Chapter Eight
Father Figure! Sherlock Holmes x Teen! Reader
Chapter Eight: Gigantic Hound
Summary: A man comes with an interesting case to (Y/N) and Sherlock, and they go on a trip to investigate.
            A few months had passed since the case with Irene, and Sherlock, (Y/N), and John had returned to their usual routine. By “usual,” that mean John putting up with Sherlock and (Y/N)’s boredom and the nonsense that came with it until an interesting case came up. It didn't help that Sherlock's mind was buzzing with the truth of (Y/N)'s parentage, and he needed a case to take his brain off it, or he'd go mad. He could hear Moriarty's words echoing within him, and his mind could come up with the most horrible ways Moriarty would use (Y/N) against him. He knew how capable Moriarty was of hurting people. He didn't want them to hurt. he wanted them safe. All in all, the stress was a burden, and it was driving him mad.
            “Nothing?” said Sherlock grumpily as John flipped through the newspaper, trying to find a topic to excite the bored detective.
            “Military coup in Uganda,” suggested John.
            “Hm.” Sherlock found it boring.
            “Another photo of us with the hats,” said (Y/N) distastefully.
            “Oh, um, Cabinet reshuffle,” said John.
            (Y/N) groaned. “Nothing interesting.”
            John sighed in exasperation. “It’s just because you two are bored by basically everything.”
            “Oh, John, I envy you so much,” said Sherlock, sighing dramatically.
            “You envy me?” asked John.
            “Your mind—it’s so placid, straightforward. Mine and (Y/N)’s —they’re like an engine, racing out of control; a rocket tearing itself to pieces trapped on the launch pad,” bemoaned Sherlock.
            “We need a case!” said (Y/N), turning over in frustration on the couch.
            “You two solved one! By harpooning a pig!” cried John. Bloody drama queens, honestly.
            “Yes, but we need the next one!” said Sherlock.
            “Is there nothing on the website?” sighed John. He felt like a babysitter.
            “Oh, yes, a fun note from a child,” sighed Sherlock.
            “ ‘Dear Mr. Sherlock Holmes and (Y/N) (L/N). I can’t find my bunny, Bluebell, anyway. Please please please can you help?’ ” recited (Y/N). They glanced at John. “And apparently, the night before Bluebell disappeared, it turned luminous. ‘Like a fairy,’ according to Kirsty. Then, poof! Bluebell was gone. Hutch locked, no sign of forced entry.”
            “Am I going to have to hear you complain forever?” grumbled John.
            “That or Cluedo,” said (Y/N).
            “Oh, no! We’re not playing that again!” said John vehemently.
            “Why not?” asked Sherlock.
            “Because I don’t hear you two bicker over whether the victim did it or not. Or whether it’s even in the rules,” said John.
            “The rules are wrong,” said (Y/N), crossing their arms.
            The doorbell rang downstairs, and the trio stopped moving.
            “Single ring,” said John.
            “Maximum pressure just under the half second,” said Sherlock.
            “Client,” summarized (Y/N). “Finally.”
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            Their new client, Henry Knight, sat in the client chair. (Y/N) hadn’t bothered to move from their couch, Sherlock sat in his armchair, and John sat in his. Henry had brought a documentary on his home, Dartmoor, and himself that now played on the TV. A strange opener for a case, but (Y/N) found that strange usually ended up interesting.
            “Dartmoor. It’s always been a place of myth and legend, but is there something else lurking out here—something very real?” asked the reporter. “Because Dartmoor’s also home to one of the government’s most secret of operations—the chemical and biological weapons research center which is said to be even more sensitive than Porton Down. Since the end of the Second World War, there’ve been persistent stories about Baskerville experiments: genetic mutations, animals grown for the battlefield. There are many that believe within this compound, in the heart of this ancient wilderness, there are horrors beyond imagining. But the real question is, are all of them still inside?”
            The setting switched to Henry sitting indoors and speaking to an offscreen interviewer. “I was just a kid. It-it was on the moor,” he said. The scene cut away to a child’s drawing of a gigantic dog with red eyes.” The caption read: Henry’s drawing (Aged 9).
            “It was dark, but I know what I saw. I know what killed my father,” said Henry ominously.
            The television switched off. Sherlock and (Y/N) were bored of the documentary. They wanted facts from Henry, not curated moments from TV.
            “What did you see?” asked Sherlock.
            “Oh. I…I was just about to say,” said Henry, pointing at the dark screen.
            “Yeah, in an edited TV interview,” said (Y/N). “We want to hear it from you.”
            “Yes, sorry, yes, of course. ‘Scuse me,” said Henry, wiping his nose with a napkin.
            Anxious, thought (Y/N). Likely trauma-induced.
            “In your own time,” said John.
            “But quite quickly,” said Sherlock, wanting to get to the case and skip the boring emotional part.
            “Do you know Dartmoor, Mr. Holmes?” asked Henry.
            “No,” said Sherlock.
            “It’s an amazing place. It’s like nowhere else. It’s sort of…bleak but beautiful,” said Henry. “We used to go for walks, after my mum died, my dad and me. Every evening we’d go out on the moor.”
            “Yes, good. Skipping to the night that your father was violently killed. Where did that happen?” questioned Sherlock.
            “There’s a place—it’s…it’s sort of a local landmark called Dewer’s Hollow. That’s an ancient name for the Devil,” said Henry.
            “Did you see the devil that night?” asked (Y/N), cocking their head.
            He looked at them, a haunted air in his eyes. “Yes…It was huge. Coal-black fur with red eyes. It got him, tore at him, tore him apart.” Henry swallowed and fidgeted nervously. “I can’t remember anything else. They found me the next morning, just wandering on the moor. My dad’s body was never found.”
            “Dog? Wolf?” hypothesized (Y/N).
            “Or a genetic experiment,” said Sherlock sarcastically.
            “Are you laughing at me?” asked Henry.
            “Why, are you joking?” asked Sherlock.
            “My dad was always going on about the things they were doing at Baskerville, about the type of monsters they were breeding there. People used to laugh at him. At least the TV people took me seriously,” muttered Henry.
            “Probably did wonders for Devon tourism,” remarked (Y/N).
            “Yeah…” said John, shifting as he realized Sherlock and (Y/N) were going down the not-so-nice questioning route. “Henry, whatever did happen to your father, it was twenty years ago. Why come to us now?”
            “I’m not sure you can help me, Mr. Holmes, since you find it all so funny,” said Henry, huffing and standing up to leave.
            “Last night,” said (Y/N), crossing their arms.
            Henry paused. “How…How do you know?”
            John sighed. Here we go again.
            “You came up from Devon on the first available train this morning. You had a disappointing breakfast. Black coffee, too. And right now you’re anxious for your first cigarette of the day,” said (Y/N). “Trust me, we can help.”
            “How on earth did you know all that?” cried Henry.
            “Punched out holes where your tickets been checked,” said Sherlock. “The train napkin you used to mop up the spilled coffee, the strength of the stain shows you didn’t take milk. There are traces of ketchup on it and around your lips and your sleep. Cooked breakfast or the nearest thing those trains can manage. Probably a sandwich,”
            “How did you know it was disappointing?” asked Henry, still bewildered.
            “It’s a train breakfast. They all are,” said (Y/N), shrugging.
            “Then there’s the nicotine stains on your fingers…your shaking fingers,” continued Sherlock. “No chance to smoke on the train, no time to roll one before you got a cab here. It’s just after 9:15. You’re desperate. The first train from Exeter to London leaves at 5:46 am.”
            “You took the earliest, so something must have happened last night. Were we wrong?” asked (Y/N), cocking their head appraisingly.
            “No, you’re right. You’re completely, exactly right. Blood hell, I heard you two were quick,” said Henry, nervously rolling a cigarette.
            “It’s our job,” said (Y/N).
            “Um, Henry, your parents both died and you were, what, seven years old?” began John tentatively.
            “I know that,” said Henry.
            “That must be quite traumatic. Have you ever thought that maybe you invented this story to account for it?” finished John.
            “That’s what Dr. Mortimer says,” said Henry.
            “Who?” asked John.
            “His therapist,” said Sherlock and (Y/N).
            “My therapist,” said Henry.
            All three spoke simultaneously.
            “Obviously,” added Sherlock.
            “Louise Mortimer. She’s the reason I came back to Dartmoor. She thinks I have to face my demons,” said Henry.
            “What happened when you went back to Dewer’s Hollow last night, Henry?” asked (Y/N), raising an eyebrow. “You went there on Dr. Mortimer’s advice, and now you want the help of detectives. What happened?”
            “It’s a strange place, the Hollow. Makes you feel so cold inside, so afraid,” murmured Henry.
            “Yes, if I wanted poetry, I’d read John’s emails to his girlfriends. Much funnier,” said Sherlock. “Now, what did you see?”
            “Footprints on the exact spot where I saw my father torn apart,” said Henry.
            Would it kill him to be more specific? thought (Y/N). “What type of footprints?” There was more to it, they could tell.
            Henry swallowed. “They were the footprints of a gigantic hound.” He was nearly hesitant to say it, knowing how ridiculous it was.
            “Say that again,” said Sherlock, leaning forward.
            “I found the footprints, they were—” began Henry.
            “No, no, no, your exact words,” interrupted Sherlock. “Repeat your exact words from a minute ago, precisely as you said them.”
            “They were the footprints of a gigantic…hound,” repeated Henry.
            “We’ll take the case,” said (Y/N). Like Sherlock, they had realized this was a very specific term to use, “hound.” That, and this was the second animal that was odd. Bluebell was the first, and little Kirsty was from the same area. This was promising indeed.
            “Sorry, what?” asked John. He was surprising something so…crazy had piqued their interest.
            “Thank you for bringing this to our attention. It’s very promising,” said Sherlock. “Baskerville…You’ve heard of it, right, John?”
            “Vaguely. It’s very hush-hush,” said John.
            “Sounds like a good place to start,” said (Y/N).
            “Ah! You’ll come down, then?” said Henry eagerly.
            “Yes, yes,” said Sherlock, waving a hand. “You go on ahead, Henry. We’ll follow later.”
            “Twenty-year-old disappearance, a monstrous hound? I wouldn’t miss this for the world!” cried Sherlock.
l
            After arriving in Dartmoor and Devon, Sherlock, (Y/N), and John checked out the countryside. Using binoculars, they spied out Baskerville and confirmed the minefield warnings around them. Afterwards, they headed to Grimpen Village where the Cross Keys Inn kept its doors open to tourists and travelers.
            “Three times a day, tell your friends. Tell anyone! Don’t be strangers and remember…stay away from the moor at night if you value your lives!” said a man trying to drum up interest in his tours.
            (Y/N) just rolled their eyes as they walked with Sherlock and John. After a quick check in, the innkeeper, Gary, grabbed their keys.
            “Here you go. Single room for you,” said Gary, handing a key to John. “And then a two bed room for you and your kid.” He handed a second key to Sherlock. Then, John ordered a drink, and he stole a receipt labeled “Undershaw Meat Suppliers.”
            “There you go,” said Gary, handing back the drink.
            “Thanks,” said John as Sherlock got up to circle the room and make deductions. “I couldn’t help noticing on the map of the moor, a skull and crossbones.”
            “Oh, that, aye,” said Gary.
            “Pirates?” asked John.
            “Eh? No, no. The Great Grimpen Minefield, they call it,” explained Gary,
            “Oh, right,” said John.
            “It’s not what you think. It’s the Baskerville testing site. It’s been going for eighty odd years. I’m not sure anyone really knows what’s there anymore,” said Gary.
            “More than just explosives?” asked (Y/N).
            Gary nodded. “Break into that place, and, if you’re lucky, you just get blown up, so they say…in case you’re planning on a nice wee stroll.”
            “I’ll remember,” said John grimly.
            “Aye. No, it buggers up tourism a bit, so thank God for the demon hound! Did you two see that show, the documentary?” asked Gary.
            “Unfortunately,” murmured (Y/N).
            “Aye, God bless Henry Knight and his monster from Hell,” said Gary jovially.
            (Y/N) leaned forward and put on the “wide-eyed-curious-teen” look. “Have you ever seen it? The hound, I mean? I love this supernatural stuff.”
            “Me? No,” said Gary. He nodded to the tour guide from earlier. “But Fletcher has. Can give you a right good story. He runs the Monster Walks for the tourists. He’s seen it.”
            “Oh, really? Thanks!” said (Y/N) with a bright-eyed smile.
            They jumped down from the barstool and went over to Sherlock. “Dad!” they said eagerly. “Gary said the tour guide, Fletcher, has seen the hound? Can we go find out?”
            Sherlock effortlessly went along with their charade. “Of course.” Together, they walked over to Fletcher, who had ordered a drink. “Excuse me, is it true?”
            Fletcher turned. “What’s true?”
            “That you’ve seen the hound,” said (Y/N), still playing their part.
            “Maybe,” said Fletcher.
            “Do you have proof? I love this type of stuff and want to know,” said (Y/N) eagerly.
            “Well, uh, I did,” said Fletcher. With an eager audience, he was willing to speak. “Once month ago, up at the hollow. It was foggy, mind—couldn’t make out a thing.”
            “I see. No witnesses, I suppose,” said Sherlock.
            “Wait!” said Fletcher, pulling out his phone. He found a picture and zoomed in. “There.” In the darkness of the photo, a four-legged something stood in the distance. Unfortunately, it’s distinct size or shape couldn’t be made out.
            “I can’t really tell what it is…” huffed (Y/N), “upset” at not having better proof.
            “Well, that’s not all. People don’t like going up there, you know—to the Hollow. Gives them a…bad sort of feeling,” said Fletcher.
            “Is rumors of being haunted supposed to be proof?” asked Sherlock doubtfully.
            “Nah, don’t be stupid, nothing like that, but I reckon there is something out there—something from Baskerville, escaped,” said Fletcher.
            “A super-dog? A terrible hound?” asked (Y/N).
            “Maybe. God knows what they’ve been spraying on us all these years or putting in the water. I wouldn’t trust ‘em as far as I could spit,” said Fletcher.
            “Is that photo the best you’ve got?” questioned Sherlock.
            Fletcher hesitated before continuing, eager to impress. “I had a mate once who worked for the MOD. One weekend we were meant to go fishin’, but he never showed up—well, not til late. When he did, he was white as a sheet. I can see him now. I’ve seen things today, Fletch, he said, that I never want to see again. Terrible things. He’d been sent to some secret army place—Porton Down, maybe; maybe Baskerville, or somewhere else. In the labs there—in the really secret labs—he’d said he’d seen…terrible things. Rats as big as dogs, he said, and dogs…dogs the size of horses.” He reached into his bag and pulled out a caste of a pawprint. A sin inch long paw print.
            Sherlock and (Y/N) raised an eyebrow in surprise. This was certainly an interesting turn of events.
            “Wow. That’s so cool. Can I take a picture?” said (Y/N) eagerly. Fletcher nodded, and they snapped a photo of the pawprint for later. “Thanks!”
            Sherlock and (Y/N) walked away and glanced at each other. It seemed the next step would be to get into Baskerville.
            “Did you bring Mycroft’s ID?” asked (Y/N).
            “Yes. Did you bring the grown-up clothes?” asked Sherlock.
            “Obviously. Can’t go into a top secret lab looking like a teenager,” said (Y/N), shrugging.
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