#tumor immunity

[ralfmaximus]

The discovery represents a potential new way to recruit the immune system to fight treatment-resistant cancers using an iteration of mRNA technology and lipid nanoparticles, similar to COVID-19 vaccines, but with two key differences: use of a patient’s own tumor cells to create a personalized vaccine, and a newly engineered complex delivery mechanism within the vaccine.

Within 48 hours, the four human study participants showed remarkable results: their immune systems went into turbo cancer-destroying mode. And without surgery, radiation, or dangerous chemotherapy.

Folks, we may have a cure for cancer within your lifetime.

[internationalbiotherapy]

Unveiling the Power of Oncolytic Viruses in Cancer Therapy: A Promising Frontier

Oncolytic viruses represent a promising frontier in cancer therapy, leveraging the innate ability of viruses to selectively target and destroy cancer cells while sparing healthy tissue. This innovative approach harnesses the dual power of direct cytotoxicity and immune system activation, offering new hope in the fight against various forms of cancer.

Historical Perspective and Evolution

The concept of using viruses to combat cancer dates back to the 1960s, when initial experiments explored the potential of viruses like poliovirus and adenovirus to induce tumor regression. These early efforts, though promising, faced significant challenges due to the potential for uncontrollable systemic infections. This led to a temporary halt in research until advances in DNA and RNA mapping technology enabled scientists to engineer safer, more targeted oncolytic viruses.

Among the most promising oncolytic viruses is the Newcastle Disease Virus (NDV). NDV specifically targets and kills cancer cells, inducing immune responses that further aid in eliminating tumors. Its unique properties make it an invaluable tool in developing personalized cancer therapies, enhancing treatment efficacy while minimizing side effects. Alongside NDV, other oncolytic viruses such as herpes simplex virus (HSV), reovirus, and vaccinia virus are being extensively studied and show significant potential in the realm of cancer treatment. Each of these viruses offers unique mechanisms of action and therapeutic benefits, broadening the scope and effectiveness of oncolytic virotherapy.

How Oncolytic Viruses Operate

Oncolytic viruses are adept at identifying and attaching themselves to cancer cells, exploiting specific receptors that distinguish them from healthy cells. Once inside the cancer cell, these viruses replicate, triggering a process known as apoptosis—programmed cell death. As infected cancer cells break down, they release new viral particles, which then proceed to infect neighboring cancer cells. This cycle continues, effectively amplifying the treatment's impact within the tumor.

Moreover, oncolytic viruses initiate an immune response against cancer cells by exposing viral antigens. This dual mechanism—direct cell destruction and immune activation—enhances the body's natural defenses against cancer, potentially eliminating residual cancer cells that conventional therapies might miss.

Enhancing Therapeutic Efficacy

To optimize the efficiency of oncolytic viruses, researchers are exploring various strategies. One approach involves combining oncolytic virotherapy with existing treatments such as radiation or chemotherapy. These therapies not only complement each other but also help mitigate immune responses that could prematurely neutralize the virus. By weakening the immune system's vigilance around the tumor site, these treatments create a more conducive environment for the oncolytic viruses to exert their effects.

Furthermore, scientists are investigating ways to augment the immune response triggered by oncolytic viruses. This includes integrating viral antigens into personalized cancer vaccines, which educate the immune system to recognize and attack cancer cells displaying these antigens. Such approaches transform "cold" tumors—those previously resistant to immune attacks—into "hot" targets for immune-mediated destruction.

Administration and Future Directions

Currently, oncolytic viruses are primarily administered intravenously or directly into localized tumors that are accessible. Intravenous administration allows for widespread dissemination of the virus throughout the body, targeting metastatic cancer cells that may have spread beyond the primary tumor site. Alternatively, direct injection into tumors converts them into sites of ongoing viral replication, essentially turning the tumor itself into an internal factory for generating anti-cancer agents.

Looking Ahead

The future of oncolytic virotherapy holds promise for further advancements. Ongoing research aims to refine virus engineering techniques to enhance tumor specificity and reduce potential side effects. Additionally, regulatory approvals for systemic administration are pending, suggesting broader accessibility and adoption of this cutting-edge treatment modality.

In conclusion, oncolytic viruses represent a paradigm shift in cancer treatment, merging virology with immunotherapy to combat malignancies in novel ways. As research continues to unravel the complexities of viral interactions with cancer cells and the immune system, the potential for personalized and potent cancer therapies continues to grow. With each breakthrough, the prospect of turning viruses once considered harmful into potent allies in the fight against cancer becomes increasingly tangible.

[jcmarchi]

Scientists Build a Molecular ‘GPS’ to Guide Cell Therapies - Technology Org

New Post has been published on https://thedigitalinsider.com/scientists-build-a-molecular-gps-to-guide-cell-therapies-technology-org/

Scientists Build a Molecular ‘GPS’ to Guide Cell Therapies - Technology Org

The ideal therapy for a disease works exclusively at the site of the disease.

But this ideal is very hard to achieve in the brain, which is wrapped in a protective barrier and contains thousands of different cell types.

The “tissue GPS” system enables engineered T-cells to deliver disease therapies to specific regions in the brain. In an early experiment, these engineered T-cells (cyan) successfully found and treated a glioblastoma (yellow) in laboratory mice. Dying tumor cells are shown in magenta, bottom.

Now, scientists at UC San Francisco have been awarded more than $30 million by the Advanced Research Projects Agency for Health (ARPA-H) to lead the Cell Therapies for Neuroinflammation and Neurodegeneration (CT-NEURO) project, which will develop a new technology dubbed “tissue GPS.”  The system uses engineered T cells to guide therapies directly to their targets in the brain to treat neurological diseases, like the deadly brain cancer glioblastoma, multiple sclerosis and Alzheimer’s.

These immune cells navigate by detecting molecular markers called antigens that appear on the surface of target cells like street addresses, replete with nine-digit zip codes. They only transfer their payload of anti-inflammatories or cancer-killing molecules once they have arrived at the right location.

The tissue GPS system may give immune cells the ability to pass through molecular gates in the blood brain barrier; find and stick to target cells; and safely deliver a tailored therapy. With such an exacting approach, the hope is that patients will be spared many of the uncomfortable or even dangerous side effects associated with other therapies.

“The field has many molecular tools that could potentially address conditions like neuroinflammation or Alzheimers, but it is challenging to know how to use these tools in a way that would precisely target the brain,” said Wendell Lim, PhD, project lead, UCSF Byers Distinguished Professor of Cellular and Molecular Pharmacology, and director of the UCSF Cell Design Institute. “Tissue GPS will ensure that therapies have a maximal effect in the right parts of the brain, making it much easier to treat complex disease.”

Disbursed over five years, the funds will support Lim and UCSF colleagues Scott Zamvil, MD, PhD; Hideho Okada, MD, PhD; Dean Sheppard, MD; and Anna Molofsky, MD, PhD, in developing the system.

The UCSF researchers will test the system’s delivery of therapies for brain tumors; neuroinflammation; demyelination (the loss of insulation on neural wires, like in multiple sclerosis); and neurodegeneration. They also will test its ability to reach other specific organs, like the lungs.

The team has mapped out antigens that are present throughout the brain, as well as the molecular sensors required for the tissue GPS to navigate to various brain regions. In an early experiment, their approach enabled engineered T-cells to treat brain tumors in mice.

“Immune cells are incredibly adept at traversing the body to reach a target,” Lim said. “These living cells could provide a powerful way to get therapies to where they need to be.”

Source: UCSF

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[luvmanifesting]

“CRAZY” things i’ve manifested from the void and my imagination.

All my family members stop aging at 22-30

Being able to endure the coldest temperatures

Being able to hear anyone from FAR FAR FAR distances

Revised my age like 3 times, i was born 2007 but permanently made myself 16

Immune to dying in any way except a peaceful death if desired

my cat living until i basically pass over (whenever i desire)

keeping everything i’ve manifested forever and if i were reincarnate i would be born with everything i had in this reality

my celebrity crush (i changed his age so it wouldn’t be weird)

Animals being able to talk to me

Everything being free for me (because i was tired of currency so basically everything for me and my family is free)

Reversed my friend’s tumor

Immune to getting any type of disease/sickness

Never a boring or dull day

Time controlling basically

Being able to stay underwater for as long as i want without coming up for air

Being able to read people like a book (no manipulation around here!!)

My english getting better (i rarely use it)

If someone has animosity towards me or is wishing harm on me (digitally,physically, internally) it will appear in my dreams and will send intense karma their way

Having a hairless body forever (except my eyebrows and eyelashes and my hair lol)

Everyday feels like 2014-2017

Being able to drive how i want and permanently avoiding all car accidents

And a lot more. sorry for the spam guys but i just wanted to put what i manifested out there since i had plenty of questions about it, if i can manifest this crazy stuff then so can you!

Until next time! (^-^)/

[dogcancerfoundation]

Frankincense Oil for Dog Tumors: A Natural Approach to Cancer Treatment

When it comes to our beloved canine companions, the mere mention of cancer can be heart-wrenching. As pet owners, we want to do everything in our power to provide effective and compassionate care for our dogs diagnosed with cancer. In recent years, alternative and complementary therapies have gained popularity in veterinary medicine, and one such treatment that has garnered attention is the use…

[truth4ourfreedom]

THE BENEFITS OF IVERMECTIN. IF YOU HAVE CANCER, FREQUENT COLD OR INFECTIONS, MUSCLE SHRINKAGE, CARDIAC ISSUES, CROHNS, HERPES, ETC.

The study was published in the Cureus Journal of Medical Science.  LET'S TALK ABOUT IVERMECTIN 1 – Ivermectin prevents the damage caused to RNA Vaccines.  2 – Ivermectin blocks the entry of Spike Protein into cells.  So, if the person was vaccinated with COVID, they have hope, they have a way to treat themselves through Ivermectin.  3 – Ivermectin is a treatment after Covid and after vaccination, it is an effective medicine in all phases of Covid 19, even before entering the cell, Ivermectin already destroys the virus in the blood.  It only has beneficial effects and no harmful effects in the treatment of the coronavirus.  4 – Ivermectin has a very powerful anti-inflammatory action against Coronavirus.  5 – Ivermectin has a powerful action for traumatic and orthopedic injuries, it strengthens muscles and has no side effects like corticosteroids.  6 – Ivermectin treats autoimmune ailments such as: rheumatoid arthritis, ankylosing spondylitis, fibromyalgia, psoriasis, Crohn's disease, allergic rhinitis.  7 – Ivermectin reduces the frequency of flu and colds.  8 – Ivermectin improves the immunity of cancer patients.  9 – Ivermectin treats Herpes Simplex and Herpes Zoster.  10 – Ivermectin reduces the frequency of sinusitis and diverticulitis.  11 – Ivermectin protects the heart in cardiac overload, in an embolism for example, it prevents cardiac hypoxia because it stimulates the production of basic energy so that the tissue is not destroyed and thus improves cardiac function.  12 – Ivermectin is antiparasitic.  13 – Ivermectin is anti-neoplastic (anti-cancer), it suppresses the proliferation and metastasis of cancer cells, only killing cancer cells and preserving healthy cells, improving the effectiveness of chemotherapy treatment, as it kills cancer cells resistant to chemotherapy, defeating the resistance to multiple chemotherapeutics that tumors develop, and combined with chemotherapy and/or anti-cancer agents, it provides an increase in the effectiveness of these treatments.  14 – Ivermectin is antimicrobial (bacteria and viruses), and increases immunity.  15 – Ivermectin reaches the Central Nervous System and regenerates the nerves.  16 – Ivermectin regulates glucose and insulin metabolism.  17 – Ivermectin regulates cholesterol metabolism.  18 – Ivermectin reduces liver fat in steatose.  19 – Ivermectin protects the liver exposed to insecticides.  20 – Ivermectin attacks the virus wherever it is, regardless of mutations.  21 – Ivermectin serves for the prevention and treatment of coronavirus, surprisingly.  Unproven efficacy is not of Ivermectin, but of vaccines.  22 – Ivermectin, used as a prophylactic agent, was associated with a significant reduction in infection, hospitalization and mortality rates due to COVID-19.  23 - Ivermectin does not attack the liver, since it is not metabolized in it, and if in the intestine, on the contrary, it protects the liver. 

BIG PHARMA DOES NOT WANT YOU TO KNOW THIS.THEY WANT TO SELL YOU THE EXPENSIVE MEDS THEY MAKE BILLIONS ON.

Please read, save and re-blog before Tumblr takes this down.

[ourpetwarehouse]

Buy Dorwest Garlic & Fenugreek Tablets For Dogs (100 Tablets)

Dorwest Garlic & Fenugreek tablets are diateries supplements containing garlic and fenugreek with white sugar coating for Dogs. Your dog will easily take it. It helps support strong immunity, healthy skin, and general health. These tablets are safe to use for dogs as young as 8 weeks old.

[reasonsforhope]

I'm worried about the rising rate of young adults getting cancer.

For what it's worth, we've actually made a shocking amount of progress against cancer - especially the most common cancers like breast cancer, and especially in the past 30 years.

Cancer rates have been falling, often dramatically (x, x, x, x, x, x). One of the best examples it that breast cancer deaths in the United States dropped 58% between 1975 and 2019 (x).

Right now, we're at the beginning of an absolute revolution in cancer care that promises to increase survival rates even further. This revolution has been going on to a lesser degree since the first human genome was successfully sequenced in the early 2000s (and in fact, the first gapless sequencing of a human genome was finally finished just two years ago, in 2022), and to a greater extent since CRISPR DNA-editing technology was first successfully tested in 2013, and since medical digitzation/digital communication and vaccination were massively spurred ahead in 2020, by the COVID pandemic (x, x).

Right now, the results of this revolution are only beginning to trickle out into actual treatments. But I guarantee you, in the next one to three decades, the way we fight cancer will be massively transformed.

We're talking personalized genome sequencing for each person with cancer - not just for early and better detection, but even to figure out what types of treatments will work best. (x, x, x, x)

We're talking using CRISPR-based DNA editing to literally cut cancer-causing mutations out of your DNA, to edit the genes of immune cells to better detect and kill cancer cells, and to kill cancer-causing viruses. (x, x, x, x)

We're talking using CRISPR-based screening to figure out how chemotherapy resistance works, so that we can overcome it - and even weaponize it. (x, x)

We're talking using CRISPR to edit immune cells so that they recognize and target the mutations of a single individual's specific tumor. (x)

We're talking new types of testing that can predict if cancer will return years before it shows up on scans. (x)

We're talking using (non-generative) AI to massively increase the accuracy and earliness of cancer detection - which by the way is already starting to happen, there are several AI-based systems that detect cancer earlier and more accurately than doctors do. (x, x, x, x, x, x)

Also, the more we transition to a green, sustainable, and ethical future, the fewer cancer-causing substances will be in the environment (fossil fuels, oil drilling, and mining are massive sources of carcinogens at every point in the process).

Cancer is awful. That is a massive understatement. But the fight against cancer is one where there are so many reasons for hope.

[reality-detective]

Stem Cell Scientist Reveals what the # 1 supplement people should take...

THE MIRACLE PLANT HAS BEEN SHOWN TO FIGHT OVER 300 DISEASES and reduce your risk of cancer, diabetes, and arthritis by 60% in just 2 months!

Moringa is full of cytokinins that are significantly slowing down the aging process, help renew every cell of the human body - making people look and feel decades younger!!! 🧬

The high amount of polyphenols reduces the inflammation by 95%, accelerates the anti-aging process and of course makes you resilient to viruses and illnesses!🧬

It’s the ultimate anti-inflammatory, anticancer, and immune-boosting superfood, proven to inhibit tumor growth and restore healthy cells. If you’re struggling with chronic illness, Moringa could be the lifeline you’ve been waiting for. 🤔

[mindblowingscience]

A fascinating new study, published in the Journal of Clinical Investigation, has revealed an unexpected potential benefit of severe COVID infection: it may help shrink cancer. This surprising finding, based on research conducted in mice, opens up new possibilities for cancer treatment and sheds light on the complex interactions between the immune system and cancer cells – but it certainly doesn't mean people should actively try to catch COVID.

Continue Reading.

[dsudis]

Histotripsy works by using targeted ultrasound waves to form microbubbles within the tumor. The forces created as those bubbles form and collapse cause the mass to break apart, killing tumor cells and leaving the debris to be cleaned up by the immune system.

What that could mean for patients is treatment without the physical toll of radiation or chemotherapy, fewer concerns with drug compatibility, far shorter recovery times than with surgery and less treatment discomfort.

And histotripsy’s potential benefits go beyond tumor destruction. In the last year, a pair of pre-clinical studies in rodents suggest that in the clean-up process, the immune system learns how to identify cancer cells as threats. This can enable the body to continue fighting the initial tumor and help activate a natural immune response to the cancer.

In the first study, even after destroying only 50% to 75% of the liver tumor volume by histotripsy, the rats’ immune systems were able to clear away the rest, with no evidence of recurrence or metastases in more than 80% of animals.

[gurggggleburgle]

A fic idea from my brain from joy sparked from @meltedmush

really fucked up in a fun way if the whole nature of the Skinhe's was a that because the system really only cares about the protagonist and good story that actually the natural state of this world is a Binghe Kronenburg nightmare. The natural state of everything is Bingflesh. The horses, grass, buildings, other humans, soup, the water anything of real substance is Luo Binghe.

It's just you don't ever see this because the system has a filter in place that hides that part of the Lynch nightmare. But the system has started to glitch and now patches of reality are coming apart and melt in a flesh nightmare where everything is just turning into Binghe creatures including actual Luo Binghe who's a bunch of little skinhes stacked on top of each other. The only person immune to the spreading Luo Binghe virus seems to be Shen Qingqiu but even then he's got to hurry up and fix whatever the hell is going on around here before all the flesh melts into one and he just becomes another Bingcreature.

The idea of Shen Qingqiu fighting through a mass of writhing bingflesh and sinew trying to dig to the real Binghe at the heart of the tumorous screaming mass of every thought Luo Binghe has ever had coupled with a whaling narration of PIDW as his skin is bursting with little tumorous binghe faces. Saving the day by diving into the body horror and telling Luo Binghe he can say anything to him. That he doesn't need to hold shit in. This is like another case where men would rather turn into a flesh nightmare then go to therapy and Shen Qingqiu just ain't having it yall