#tumor immunity

[lipstickontheglass1985]

they inject tumors into mice balls????????

[ralfmaximus]

The discovery represents a potential new way to recruit the immune system to fight treatment-resistant cancers using an iteration of mRNA technology and lipid nanoparticles, similar to COVID-19 vaccines, but with two key differences: use of a patient’s own tumor cells to create a personalized vaccine, and a newly engineered complex delivery mechanism within the vaccine.

Within 48 hours, the four human study participants showed remarkable results: their immune systems went into turbo cancer-destroying mode. And without surgery, radiation, or dangerous chemotherapy.

Folks, we may have a cure for cancer within your lifetime.

[internationalbiotherapy]

Unveiling the Power of Oncolytic Viruses in Cancer Therapy: A Promising Frontier

Oncolytic viruses represent a promising frontier in cancer therapy, leveraging the innate ability of viruses to selectively target and destroy cancer cells while sparing healthy tissue. This innovative approach harnesses the dual power of direct cytotoxicity and immune system activation, offering new hope in the fight against various forms of cancer.

Historical Perspective and Evolution

The concept of using viruses to combat cancer dates back to the 1960s, when initial experiments explored the potential of viruses like poliovirus and adenovirus to induce tumor regression. These early efforts, though promising, faced significant challenges due to the potential for uncontrollable systemic infections. This led to a temporary halt in research until advances in DNA and RNA mapping technology enabled scientists to engineer safer, more targeted oncolytic viruses.

Among the most promising oncolytic viruses is the Newcastle Disease Virus (NDV). NDV specifically targets and kills cancer cells, inducing immune responses that further aid in eliminating tumors. Its unique properties make it an invaluable tool in developing personalized cancer therapies, enhancing treatment efficacy while minimizing side effects. Alongside NDV, other oncolytic viruses such as herpes simplex virus (HSV), reovirus, and vaccinia virus are being extensively studied and show significant potential in the realm of cancer treatment. Each of these viruses offers unique mechanisms of action and therapeutic benefits, broadening the scope and effectiveness of oncolytic virotherapy.

How Oncolytic Viruses Operate

Oncolytic viruses are adept at identifying and attaching themselves to cancer cells, exploiting specific receptors that distinguish them from healthy cells. Once inside the cancer cell, these viruses replicate, triggering a process known as apoptosis—programmed cell death. As infected cancer cells break down, they release new viral particles, which then proceed to infect neighboring cancer cells. This cycle continues, effectively amplifying the treatment's impact within the tumor.

Moreover, oncolytic viruses initiate an immune response against cancer cells by exposing viral antigens. This dual mechanism—direct cell destruction and immune activation—enhances the body's natural defenses against cancer, potentially eliminating residual cancer cells that conventional therapies might miss.

Enhancing Therapeutic Efficacy

To optimize the efficiency of oncolytic viruses, researchers are exploring various strategies. One approach involves combining oncolytic virotherapy with existing treatments such as radiation or chemotherapy. These therapies not only complement each other but also help mitigate immune responses that could prematurely neutralize the virus. By weakening the immune system's vigilance around the tumor site, these treatments create a more conducive environment for the oncolytic viruses to exert their effects.

Furthermore, scientists are investigating ways to augment the immune response triggered by oncolytic viruses. This includes integrating viral antigens into personalized cancer vaccines, which educate the immune system to recognize and attack cancer cells displaying these antigens. Such approaches transform "cold" tumors—those previously resistant to immune attacks—into "hot" targets for immune-mediated destruction.

Administration and Future Directions

Currently, oncolytic viruses are primarily administered intravenously or directly into localized tumors that are accessible. Intravenous administration allows for widespread dissemination of the virus throughout the body, targeting metastatic cancer cells that may have spread beyond the primary tumor site. Alternatively, direct injection into tumors converts them into sites of ongoing viral replication, essentially turning the tumor itself into an internal factory for generating anti-cancer agents.

Looking Ahead

The future of oncolytic virotherapy holds promise for further advancements. Ongoing research aims to refine virus engineering techniques to enhance tumor specificity and reduce potential side effects. Additionally, regulatory approvals for systemic administration are pending, suggesting broader accessibility and adoption of this cutting-edge treatment modality.

In conclusion, oncolytic viruses represent a paradigm shift in cancer treatment, merging virology with immunotherapy to combat malignancies in novel ways. As research continues to unravel the complexities of viral interactions with cancer cells and the immune system, the potential for personalized and potent cancer therapies continues to grow. With each breakthrough, the prospect of turning viruses once considered harmful into potent allies in the fight against cancer becomes increasingly tangible.

[luvmanifesting]

“CRAZY” things i’ve manifested from the void and my imagination.

All my family members stop aging at 22-30

Being able to endure the coldest temperatures

Being able to hear anyone from FAR FAR FAR distances

Revised my age like 3 times, i was born 2007 but permanently made myself 16

Immune to dying in any way except a peaceful death if desired

my cat living until i basically pass over (whenever i desire)

keeping everything i’ve manifested forever and if i were reincarnate i would be born with everything i had in this reality

my celebrity crush (i changed his age so it wouldn’t be weird)

Animals being able to talk to me

Everything being free for me (because i was tired of currency so basically everything for me and my family is free)

Reversed my friend’s tumor

Immune to getting any type of disease/sickness

Never a boring or dull day

Time controlling basically

Being able to stay underwater for as long as i want without coming up for air

Being able to read people like a book (no manipulation around here!!)

My english getting better (i rarely use it)

If someone has animosity towards me or is wishing harm on me (digitally,physically, internally) it will appear in my dreams and will send intense karma their way

Having a hairless body forever (except my eyebrows and eyelashes and my hair lol)

Everyday feels like 2014-2017

Being able to drive how i want and permanently avoiding all car accidents

And a lot more. sorry for the spam guys but i just wanted to put what i manifested out there since i had plenty of questions about it, if i can manifest this crazy stuff then so can you!

Until next time! (^-^)/

[reasonsforhope]

"Researchers at the National Cancer Research Centre in Spain (CNIO) have discovered a mechanism that is triggered just minutes after acute liver damage occurs—and it could lead to treatments for those with severe liver problems.

The avenues for future treatments of liver damage include a diet enriched with the amino acid glutamate.

“Glutamate supplementation can promote liver regeneration and benefit patients in recovery following hepatectomy or awaiting a transplant,” wrote the authors in a paper published in ‘Nature’.

The liver is a vital organ, crucial to digestion, metabolism, and the elimination of toxins. It has a unique ability to regenerate, which allows it to replace liver cells damaged by the very toxins that these cells eliminate.

However, the liver stops regenerating in cases of diseases that involve chronic liver damage–such as cirrhosis—and such diseases are becoming increasingly prevalent, associated with poor dietary habits or alcohol consumption. So activating liver regeneration is key to treating the disease.

Learning to activate liver regeneration is therefore a priority today, to benefit patients with liver damage and also those who’ve had part of their liver cut out to remove a tumor.

The research has discovered in animal models this previously unknown mechanism of liver regeneration. It is a process that is triggered very quickly, just a few minutes after acute liver damage occurs, with the amino acid glutamate playing a key role.

“Our results describe a fundamental and universal mechanism that allows the liver to regenerate after acute damage,” explained Nabil Djouder, head of the CNIO Growth Factors, Nutrients and Cancer Group and senior author of the study.

A “complex and ingenious” perspective on liver regeneration

Liver regeneration was known to occur through the proliferation of liver cells, known as hepatocytes. However, the molecular mechanisms involved were not fully understood. This current discovery is very novel, as it describes communication between two different organs, the liver and bone marrow, involving the immune system, according to a CINO news release.

The results show that liver and bone marrow are interconnected by glutamate. After acute liver damage, liver cells, called hepatocytes, produce glutamate and send it into the bloodstream; through the blood, glutamate reaches the bone marrow, inside the bones, where it activates monocytes, a type of immune system cell. Monocytes then travel to the liver and along the way become macrophages – also immune cells. The presence of glutamate reprograms the metabolism of macrophages, and these consequently begin to secrete a growth factor that leads to an increase in hepatocyte production.

In other words, a rapid chain of events allows glutamate to trigger liver regeneration in just minutes, through changes in the macrophage metabolism. It is, says Djouder, “a new, complex and ingenious perspective on how the liver stimulates its own regeneration.”

The research also clarifies a previously unanswered question: how the various areas of the liver are coordinated during regeneration. In the liver, there are different types of hepatocytes, organized in different areas; the hepatocytes in each area perform specific metabolic functions. The study reveals that hepatocytes producing a protein known as glutamine synthetase, which regulates glutamate levels, play a key role in regeneration.

According to the CNIO group, when glutamine synthetase is inhibited, there is more glutamate in circulation, which accelerates liver regeneration. This is what happens when the liver suffers acute damage: glutamine synthase activity decreases, blood glutamate increases, and from there, the connection with the bone marrow is established, reprogramming macrophages and stimulating hepatocyte proliferation.

Possible therapeutic applications

The experiments have been carried out in mice, but the results have been tested with bioinformatics tools, using databases of mouse and human hepatocytes.

According to Djouder, “dietary glutamate supplementation may simply be recommended in the future after liver extirpation, and also to reduce liver damage caused by cirrhosis.”

The first author of the paper, CNIO researcher María del Mar Rigual also wants future research to explore using glutamate supplements in humans who have undergone liver resection for tumor removal."

-via Good News Network, March 30, 2025

[mariacallous]

Remember ivermectin? The animal-deworming medication was used so avidly as an off-label COVID treatment during the pandemic that some feed stores ended up going out of stock. (MUST SHOW A PIC OF YOU AND YOUR HORSE, a sign at one demanded of would-be customers in 2021.) If you haven’t heard about it since, then you’ve existed blissfully outside the gyre of misinformation and conspiracies that have come to define the MAGA world’s outlook on medicine. In the past few years, ivermectin’s popularity has only grown, and the drug has become a go-to treatment for almost any ailment whatsoever. Once a suspect COVID cure, now a right-wing aspirin.

In fact, ivermectin never really worked for treating SARS-CoV-2 infections. Many of the initial studies that hinted at a benefit turned out to be flawed and unreliable. By 2023, a series of clinical trials had already proved beyond a doubt that ivermectin won’t reduce COVID symptoms or mortality. But these findings mattered little to its fans, who saw the drug as having earned the status of dissident antiviral—a treatment that they believed had been suppressed by the medical establishment. And if ivermectin was good enough to be rejected by mainstream doctors as a cure for COVID, health-care skeptics seemed to reason, then surely it must have a host of other uses too.

As a physician who diagnoses cancer, I have come across this line of thinking in my patients, and found that some were using ivermectin to treat their life-threatening tumors. Nicholas Hornstein, a medical oncologist in New York City, told me that he’s had the same experience: About one in 20 of his patients ask about the drug, he said. He remembers one woman who came into his office with a tumor that was visibly protruding from her abdomen, having swapped her chemotherapy for some ivermectin that she’d picked up at a veterinary-supply store. “It’s going to work any day now,” he says she told him when he tried to intervene.

The idea that ivermectin could be a cancer-fighting agent does have some modest basis in reality: Preliminary studies have suggested that antiparasitic medications might inhibit tumor growth, and at least one ongoing clinical trial is evaluating ivermectin’s role as an adjunct to cancer treatment. That study has enrolled only nine patients, however, and the results so far show that just one patient’s tumor actually shrank, according to a recent scientific abstract. But these meager grounds for hope now support a towering pile of expectations.

Cancer is just one of many illnesses that ivermectin is supposed to heal. According to All Family Pharmacy, a Florida-based company that promotes the compound to fans of Donald Trump Jr., Dan Bongino, Matt Gaetz, and Laura Ingraham on their podcasts and shows, the drug has “anti-inflammatory properties that could help keep the immune system balanced in fighting infection.” (The company did not respond to a request for comment.) In sprawling Facebook groups devoted to ivermectin’s healing powers, the claims are more extreme: The drug can combat a long list of conditions, members say, including Alzheimer’s disease, heart disease, diabetes, autism, carpal tunnel syndrome, crow’s feet, brain fog, and bee stings.

As a medication that supposedly was censored by elites—if not canceled outright by woke medicine and Big Pharma—ivermectin has become a symbol of medical freedom. It’s also a MAGA shibboleth: Republican-leaning parts of the country helped drive an astounding 964 percent increase in prescriptions for the drug early in the pandemic, and GOP members of Congress have used their official posts to advocate for its benefits. Ivermectin can now be purchased without a prescription in Arkansas and Idaho, and other states are considering similar measures.

Health and Human Services Secretary Robert F. Kennedy Jr. has been a particularly strong proponent. In his 2021 book about the pandemic, Kennedy referred to the “massive and overwhelming evidence” in ivermectin’s favor, and invoked its “staggering, life-saving efficacy.” He also argued at great length that the pharmaceutical industry—with the support of Anthony Fauci and Bill Gates—had engaged in a historic crime by attempting to discourage its use. Jay Bhattacharya, the director of the National Institutes of Health, has similarly backed the conspiracy theory that the use of ivermectin was dismissed by “the powers that be” in an apparent ploy to ease the approval of COVID vaccines. (Not everyone in the current administration is a fan: Before he became the FDA’s vaccine czar, the oncologist Vinay Prasad publicly disputed Kennedy’s views on ivermectin, and earlier this year he called its use for cancer “the right’s version of masking on the airplane and praying to Lord Fauci.”) In response to questions about Kennedy’s and Bhattacharya’s current views on ivermectin, the HHS press secretary Emily Hilliard told me that they “continue to follow the latest scientific research regarding therapeutic options for COVID-19 and other illnesses.” She did not respond to questions about Prasad.

The idea of using antiparasitic drugs as cancer treatments was already taking hold by the late 2010s, Skyler Johnson, a Utah radiation oncologist who studies medical misinformation, told me. In January 2017, a man with lung cancer named Joe Tippens started on a dewormer called fenbendazole, which had been suggested to him by a veterinarian. Daniel Lemoi, who had Lyme disease, had started taking ivermectin in 2012 after reading a paper on the genetic similarities between humans and horses. Tippens would go on to achieve global fame among desperate cancer patients, and Lemoi became an ivermectin influencer during the pandemic.

Since then, a gaggle of dubious doctors has worked to bolster the credibility of deworming drugs within alternative medicine and anti-vaccine circles. Their underlying pitch has become familiar in the past few years: Health experts can’t be trusted; the pharmaceutical industry is suppressing cheap cures; and patients deserve the liberty to choose their own medical interventions. For the rest of the medical establishment, the worldview this entails is straining doctor-patient relationships. Johnson told me that many of his patients are now skeptical of his advice, if not openly combative. One cancer patient accused Johnson of bias when he failed to recommend ivermectin. The drug is so cheap and effective, this patient had concluded, that Johnson would be out of a job if everyone knew about it. (Johnson told me that he offers patients “the best possible treatment, no matter the financial incentive.”) Ivermectin has become a big business in its own right. Online pharmacies and wellness shops are cashing in on the deworming craze, with one offering parasite cleanses for $200 a month. Meanwhile, fringe doctors can charge patients who have cancer and other diseases thousands of dollars to prescribe such treatments.

Johnson’s own experience suggests that the cult of ivermectin is growing larger. He told me that he’s seen his patients’ interest in the drug explode since January, when the actor Mel Gibson went on Joe Rogan’s podcast and claimed that three of his friends had beat back their advanced tumors with ivermectin and fenbendazole, among various other potions. “This stuff works, man,” Gibson said. Meanwhile, in the ivermectin Facebook groups—including one with close to 300,000 members—the public can read posts from a woman with breast cancer considering using ivermectin in lieu of hormone treatments; a leukemia patient who has given up on chemotherapy to “see what happens” with antiparasitic drugs; or a concerned aunt wondering if the drugs might help her little niece with Stage 4 cancer.

But ivermectin advocacy is most disturbing in its totalizing form, wherein parasites—which is to say, the pathogens against which the drug truly is effective—are reimagined as the secret cause of many other unrelated problems. In the Facebook groups, members will share images of what they say are worms that have been expelled from their bodies by treatment. (This phenomenon brings to mind a different disease entirely: delusional parasitosis.) One recent post from the daughter of a Stage 4 lung-cancer patient showed a bloody glob that had “dropped down into her mouth.” Commenters debated whether this might be a worm or something else. “Blood clot from Covid vax?” one suggested. A few days later, the daughter gave an update: Her mom had gone to see the doctor, who informed her that she’d likely coughed up a piece of her own lung.

The whole exchange provides a sad illustration of this delirious and desperate time. Before it turned into a conservative cure-all, ivermectin was legitimately a wonder drug for the poorest people on Earth. Since its discovery in 1973, it has become a leading weapon in the fight against horrific infections such as river blindness and elephantiasis. Yet now that substantial success seems to have given birth to a self-destructive fantasy.

A decade ago, the co-discoverers of ivermectin—William Campbell and Satoshi Ōmura—were awarded a Nobel Prize in recognition of their contribution to reducing human suffering. In his formal lecture to the Academy, Campbell offered some reflections on the simple science that gave rise to the treatment, and to its wide array of applications. But his speech contained a warning, too, that any medicine that works so broadly and so well runs the risk of being handed out too often. The more benefits that such a drug provides, he told the audience in Stockholm, “the more we must guard against the hazards of indiscriminate use.”

[reality-detective]

Stem Cell Scientist Reveals what the # 1 supplement people should take...

THE MIRACLE PLANT HAS BEEN SHOWN TO FIGHT OVER 300 DISEASES and reduce your risk of cancer, diabetes, and arthritis by 60% in just 2 months!

Moringa is full of cytokinins that are significantly slowing down the aging process, help renew every cell of the human body - making people look and feel decades younger!!! 🧬

The high amount of polyphenols reduces the inflammation by 95%, accelerates the anti-aging process and of course makes you resilient to viruses and illnesses!🧬

It’s the ultimate anti-inflammatory, anticancer, and immune-boosting superfood, proven to inhibit tumor growth and restore healthy cells. If you’re struggling with chronic illness, Moringa could be the lifeline you’ve been waiting for. 🤔

[mindblowingscience]

Researchers have developed an innovative dual-receptor T-cell therapy that promises safer and more effective cancer treatments. This study, published in Cell, demonstrates that engineering T-cells to express both a Chimeric Antigen Receptor (CAR) and a T-cell Receptor (TCR) can improve their ability to distinguish between cancerous and healthy tissues—addressing a major challenge in current immunotherapy. Treatments involving the use of the body's immune system to fight cancer have led to significant improvements in patient survival in recent years, particularly using a method called CAR T-cell therapy. This treatment involves extracting a patient's own T-cells and modifying them in a lab to express a special receptor called a Chimeric antigen receptor (CAR) that recognizes a tumor protein. These are then reinfused back into the patient, where they can find and destroy cancer cells.

Continue Reading.

[dsudis]

Histotripsy works by using targeted ultrasound waves to form microbubbles within the tumor. The forces created as those bubbles form and collapse cause the mass to break apart, killing tumor cells and leaving the debris to be cleaned up by the immune system.

What that could mean for patients is treatment without the physical toll of radiation or chemotherapy, fewer concerns with drug compatibility, far shorter recovery times than with surgery and less treatment discomfort.

And histotripsy’s potential benefits go beyond tumor destruction. In the last year, a pair of pre-clinical studies in rodents suggest that in the clean-up process, the immune system learns how to identify cancer cells as threats. This can enable the body to continue fighting the initial tumor and help activate a natural immune response to the cancer.

In the first study, even after destroying only 50% to 75% of the liver tumor volume by histotripsy, the rats’ immune systems were able to clear away the rest, with no evidence of recurrence or metastases in more than 80% of animals.

[gurggggleburgle]

A fic idea from my brain from joy sparked from @meltedmush

really fucked up in a fun way if the whole nature of the Skinhe's was a that because the system really only cares about the protagonist and good story that actually the natural state of this world is a Binghe Kronenburg nightmare. The natural state of everything is Bingflesh. The horses, grass, buildings, other humans, soup, the water anything of real substance is Luo Binghe.

It's just you don't ever see this because the system has a filter in place that hides that part of the Lynch nightmare. But the system has started to glitch and now patches of reality are coming apart and melt in a flesh nightmare where everything is just turning into Binghe creatures including actual Luo Binghe who's a bunch of little skinhes stacked on top of each other. The only person immune to the spreading Luo Binghe virus seems to be Shen Qingqiu but even then he's got to hurry up and fix whatever the hell is going on around here before all the flesh melts into one and he just becomes another Bingcreature.

The idea of Shen Qingqiu fighting through a mass of writhing bingflesh and sinew trying to dig to the real Binghe at the heart of the tumorous screaming mass of every thought Luo Binghe has ever had coupled with a whaling narration of PIDW as his skin is bursting with little tumorous binghe faces. Saving the day by diving into the body horror and telling Luo Binghe he can say anything to him. That he doesn't need to hold shit in. This is like another case where men would rather turn into a flesh nightmare then go to therapy and Shen Qingqiu just ain't having it yall

[stevishabitat]

In the search for a cure for breast cancer, a major breakthrough has finally come. Biotechnology company Anixa Biosciences, Inc. announced earlier this month that its breast cancer vaccine, which is being designed with the help of the Cleveland Clinic, has completed phase one of its clinical testing. It will be moving forward to the next stages of development, and if all goes to plan, doctors may soon be able to stop cancerous tumors from forming.

“The vaccine is designed to mobilize the patient’s immune system to find, recognize, and destroy breast cancer cells for primary prevention,” Amit Kumar, Ph.D, CEO of Anixa Biosciences, Inc., tells Vogue. “If a patient is vaccinated and [their] immune system is trained to destroy the cancer cells when the cancer appears, the vaccinated immune system will destroy the cells before they can grow into a cell tumor.”

The vaccine, which comes in a set of three shots given to patients two weeks apart, specifically targets alpha-lactalbumin, a milk protein that is produced during lactation. It is typically not found after lactation in normal breast tissue, but scientists have found that the protein is expressed in about 70% of triple-negative breast cancer (TNBC) cases. The hope, Rima Patel, MD, oncologist and assistant professor in the division of hematology and medical oncology at Mount Sinai, explains, is that the vaccine can train people’s immune system to recognize the protein as harmful and attack it before it turns into cancer.

“It is designed to alert the immune system to attack a breast tumor, before it can develop or recur, and prevent it from growing,” says Dr. Patel. “It has been studied in an early phase one clinical trial in 35 women who had a history of early-stage TNBC and are at high risk of recurrence, and in patients without a history of cancer but are at high risk of developing breast cancer due to a genetic predisposition or other factors. The study thus far showed that the vaccine is overall well tolerated and resulted in an immune response in most patients.”

Research in mice shows that the vaccine has been successful in activating the immune system against alpha-lactalbumin and preventing breast tumors in these small creatures. While the vaccine shows promise in humans, Dr. Kumar says they have to test larger numbers and with control groups in the next phases to show its efficacy and safety.

[nanamineedstherapy]

In Ratio Veritas: Someone got Nanami Kento Pregnant & it's not Gojo Satoru

F!Pregnant Reader x Gojo Satoru x Pregnant Special Grade Nanami Kento

Previous Oneshot Chapter [Tumblr/Ao3] | Main Series [Tumblr/Ao3]

A/N: This fic will be equally upsetting to biologists, theologians, HR departments, and anyone who thought Nanami was immune to life's worst plot twists. You are welcome.

Nanami hadn’t spoken in two hours.

That alone wasn’t unusual. What was unusual was the silence had weight to it—not his usual melancholic withdrawal or exhausted tolerance of Gojo’s existence. No, this was weaponized stillness. A silence that could sit across a kitchen island and gut you alive.

You’d broken something.

Not a plate. Not the sacred morning coffee ritual. Something bigger. Something cellular.

“Are you sure it’s mine?” You asked, for the seventh time, voice barely above a whisper.

Nanami looked up, slowly. His expression was unreadable, a perfect mask of corporate detachment, like he was about to fire you from your own marriage.

“You were the only one inside me,” he said flatly, sipping ginger tea.

You blinked. “I wasn’t trying to be inside you—”

“It happened.”

He punctuated that with a glare sharp enough to sever timelines.

It had happened. One late night. There was blood—just yours. Gojo had been out of town. You’d both been emotionally vulnerable (and three drinks into the rare Nanami-approved wine). And then there was the cursed object you definitely shouldn’t have touched. It pulsed once, muttered something about fertility and legacy in Akkadian, and exploded like an overripe peach.

Three weeks later, Nanami threw up on your Birkin rug.

“I thought it was food poisoning,” he said, as if blaming you for your tragic biryani attempt.

“Nanamin,” you said, stepping carefully around the part where he looked genuinely ready to tear open his own stomach. “Men don’t get pregnant.”

“I’m not ‘men.’ I’m a goddamn special grade,” he growled. “And apparently, you’re the sort of reckless sorcerer who gets her partners cursed with divine-level mpreg.”

You flinched. “That’s not a real classification.”

“I had a meeting with Shoko. She made a new one just for me.”

Oh no.

You sat down. Slowly. Hands folded in your lap like you were at a parent-teacher conference and the fetus had already been suspended from school.

Nanami’s breathing had evened out. Too even. Terrifyingly composed.

“So,” he said, finally. “Do we keep it?”

You looked at him.

At his clenched jaw. The flicker of fear behind his lashes. His giant cursed-enhanced hand already resting low over a stomach that wasn’t showing yet, but you both knew would be. Too soon. Too fast. Like everything in this hellish life.

“I… I’ll do whatever you want,” you said honestly, voice catching. “You didn’t ask for this.”

He didn’t respond.

He stood up, walked over, and placed your hand over his stomach.

“I didn’t ask for you either,” he murmured, eyes flicking down. “But here we are.”

Your throat closed.

A long pause.

“I will murder Gojo if he finds out,” Nanami added grimly. “He’ll never shut up.”

You nodded. “We could fake a hernia.”

“Make it look like an ectoplasmic tumor?”

“Say the baby’s mine but from a different cursed object?”

“I’m not telling the raccoon,” he said sharply.

Cloud Save, from under the sofa, chirped in betrayal.

---

Three weeks later.

Nanami, visibly pregnant, in maternity trousers you custom-designed with a built-in tactical holster, sat on the edge of your shared bed, eating pickled mango and glaring at your feet.

“You did this to me,” he reminded you.

“I made you tiramisu,” you reminded him back.

“I hate sweet things.”

“I added anchovies.”

He paused. Then nodded, grimly. “Acceptable.”

Gojo burst into the room seconds later. “GUYS. WHY IS NANAMI HOTTER THAN ME AND PREGNANT—wait, whose demon spawn is that?!”

Nanami drew a blade.

You handed him a ratio-boosted nursing pillow.

The saga had just begun.

VOGUE INTERVIEW EXCERPT—Sorcerer Dads & The Gender Conspiracy: Inside the Quiet Storm of Nanami Kento’s Pregnancy

Is masculinity over? Did Gojo Satoru invent mpreg?

Interviewer: So, to clarify, Nanami-san has always identified as a man?

You (blinking slowly, deadpan) : Yes.

Nanami (tight smile, visibly pregnant, flipping through Economist mid-interview): That is correct. I’ve never not been a man.

Gojo (sipping bubble tea with two straws, one for himself, one for your belly) : I told him to let me take the fall. I offered to be the public face of this pregnancy. But nooo, Mr. Fiscal Responsibility wants full custody and the moral high ground.

You: You’re not the father.

Gojo (gasps): We agreed we’d never say that on record!

Online reaction — hours later:

@theREALbabywitch: Nanami has always been a man? Lmfao, okay. And my dad didn’t leave me.

@satoruslegs.official: If Gojo isn’t the father, why does the fetus have white hair on the ultrasound?

@mpreg4liberation: What we’re NOT gonna do is erase Gojo’s struggle as a transracial, interdimensional birth doula.

@KaoriMyChildUgly: This is good motivation. I’ll try harder with my husband.

DELIVERY ROOM: 3:24 A.M.

Shoko’s voice is calm. The lights are too bright. Nanami’s death-grip on your hand is fracturing your wrist and your worldview.

“They said it was a girl,” he pants, his face soaked in sweat, salt, and silent regret. “They said she’d have your brain.”

You are sobbing. Gojo is passed out on the floor. Feral Slay: livestreaming.

You hear the cry. Something is placed in your arms. It's... glowing?

And then—

You wake up.

Room dark. Curtains drawn. Sheets warm.

You’re in bed. No beeping monitors. No blood. No fan edits of Nanami breastfeeding on your Twitter feed.

Nanami’s asleep beside you, arm over his eyes, the peaceful expression of someone not gestating anything except contempt for capitalism. Gojo is sprawled on the floor, hugging a pillow he thinks is you.

Your hands go to your belly.

Round with yours and their twins kicking.

Soft.

Human.

Real.

You inhale. Exhale. Roll over. Reach out.

Touch Nanami’s face—thumb gently tracing the sharp cheekbone, the faintest curve of lips that still, somehow, pout in sleep.

He stirs.

“Mmm?”

“Nothing,” you whisper, letting your head rest against his chest. “Just checking.”

His arm finds you in the dark, protective. Solid. Not pregnant.

You sigh.

Thank god.

(And yet—deep inside—a tiny part of you wonders: would he have kept it?)

---

A/N: It’s easy to laugh at cursed mpreg until you realize the real horror was always the possibility of loss. If your chest aches a little tonight, blame me—or better yet, blame the gods who cursed Nanami to care so much in a world built to break him. (P.S. No, you’re not getting Gojo’s doula playlist. It’s just thirty remixes of "Take Me to Church.") (P.P.S. No raccoons were harmed during the birthing scene, though Gojo might sue for emotional damage.)

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Another fic where you got TrueForm Sukuna & Gojo Pregnant - 🤰 Help! I'm a Woman & I Got My Two Male Boyfriends Pregnant 🤰 [Tumblr/Ao3]

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