#there’s more obviously

[conjectureand-gloom]

things i’ve sworn off doing with my future kids

- pressuring them into anything

- commenting on their body

- reading their texts/journals

- ignoring them when they discuss their hobbies

- ignoring them full stop

- shaming them for anything

- giving them the silent treatment rather than communicating what’s happened

- basically anything that will make them feel as if they can’t talk to me

[inkskinned]

she's singing in another room and my dog is asleep at my feet. my grandma asked me why i haven't found a man yet and i laughed. oh, you know. i like my house clean.

my girlfriend is also my man is also "my partner" if i'm in a professional setting. yesterday we went to a ren faire and a man mimed at me - you're together? and at my delighted nod, his baffled, you're gay? made me laugh. a woman with rainbow hair said i love the two of you together. you're both so beautiful it's absurd.

my dad introduced my partner as my "..... friend. or whatever" the other day. he knows we're dating. in the same way, i was never able to get my sister's husband to stop saying that's gay like it's 2008. he still uses the word fa***t, and my sister's defense of him has always been well, he's just kidding.

my lover and i dance to old music in a tiny kitchen. we judge new music together and take food critique very seriously. we watch love is blind before we fall asleep and agree that if they had a queer season, it would be bloody but also make for excellent tv. of fucking course queer people would know someone for only 2 weeks and agree to get married. what are you saying.

at a bar with friends, a man puts his hand on my wrist. got a boyfriend? and yes, i do have a boyfriend, she's amazing. i am texting her while i wander around a gas station named after geese. i am visiting a swing state for a wedding. in the candy aisle i overhear: she's actually like a lesbian it's disgusting. two teenage girls with packaged sandwiches in their hands, giggling. no literally, like. i'm not, like. okay with her being there while we're all, like, naked and changing.

my girlfriend and i tailgate, drink gin and cider out of cups. from the frat group beside us, a man corrects himself with one of his friends: bro, i mean, nonbinary entity, and it makes everyone around him laugh, myself included. he razzes his friend the same way i would have killed for at 19 years old - like nothing happened, he continues: you apply sunscreen like an alien. he does a little sassy (and fairly accurate) dance interpretation of the motion. his friend is laughing so hard they're crying.

i am lucky, i live in a safe neighborhood in a safe state. my masc passenger princess comes up from DC. i drive her for an hour to where all the leaves are a violent arrangement of color. we walk along the trails, letting autumn into our blood. in this part of the state, there's a lot of pickup trucks and trump signs. when we chastely kiss before getting into the car, i accidentally make eye contact with a woman holding her child's wrist. she looks disgusted. she looks fucking pissed.

two hours later my girl and i are eating dinner on a patio, soaking in the last warmth of new england sun before the chill of winter sets in. we are giggling and trying to talk through plastic vampire teeth. at another table, i see a young woman sit up straighter. i watch her watch us. she blushes and takes her partner's hand from across the table. shy, like the taste of evening has just become something deeper.

it's worth it for this moment, i think. my lover is still humming the same song she's been singing for four days straight and i don't want to kill her for it. her guitar is beside my bed. her toothbrush is in my bathroom. in a few moments i will make us lunch. we are lucky enough to have found each other. it is lucky enough to be in love.

[kilometresrufflefuck]

just realised the most important one didn't attach to the last post

[egophiliac]

it's never the last time.

I was trying to justify to myself having Leona know how to use a waffle maker, and. well. sometimes you just gotta go where the flow takes you.

[chloesimaginationthings]

"They call it the MANGLE" - FNAF 2 phone guy

[dykeofmisfortune]

i LOVE IT WHEN REDEEMABLE CHARACTERS RELAPSE INTO THEIR OLD WAYS!!! WHEN THEY GO BACK TO THE DARK SIDE!!! TO THE FEIGNED COMFORT OF WHEN THINGS FELT GOOD!! BUT THEY LEARNED SO MANY THINGS ABOUT THEMSELVES THAT THE OLD PLACE DOESN'T TRULY FEEL AT HOME EITHER, BUT IT'S THE ONLY PLACE TO RUN TO!!!! HELLLL YEAH

[spookygibberish]

Silly design exercise in which I customize the homunculi and throw them into blenders

[violent138]

Alfred totally brags about the kids in public, simultaneously shading Bruce who cannot defend himself using Batman:

Alfred: "Master Duke was a Gotham Genius Grant finalist at 12, and Miss Gordon holds multiple degrees." *side eyes Bruce*

Bruce:

Or

"Oh, Master Dick restored the car himself, he's got a phenomenal skill with automobiles, much like the late Dr.Wayne himself."

Outsider: "Too bad it skipped you, huh Bruce? Can't even change a spare tire."

Bruce: *seething quietly* "I wonder where he gets it."

And

A visitor to Wayne Manor: "These are lovely portraits."

Alfred: "The work of Master Damian, he's practically a prodigy. It's a relief that someone in the family is appreciative of the arts."

Bruce: "I appreciate art--"

Alfred: "Twelve years of piano lessons and nothing to show for it."

Later in the Cave

Bruce: "I appreciate art."

Alfred: "Apologies Master Bruce, it's a little hard to see things around here as you seem to think black is the last remaining colour in the world."

Bruce:

[reasonsforhope]

A new treatment combining ReCET and semaglutide could eliminate the need for insulin in type 2 diabetes, with 86% of participants in a study no longer requiring insulin therapy. The treatment was safe and well-tolerated, and further trials are planned to confirm these results.

Groundbreaking research presented at UEG Week 2024 introduces a promising new treatment approach for type 2 diabetes (T2D) that has the potential to greatly reduce or even eliminate the need for insulin therapy.

This innovative approach, which combines a novel procedure known as ReCET (Re-Cellularization via Electroporation Therapy) with semaglutide, resulted in the elimination of insulin therapy for 86% of patients.

Globally, T2D affects 422 million people... While insulin therapy is commonly used to manage blood sugar levels in T2D patients, it can result in side effects... and further complicate diabetes management. [Note: Also very importantly it's fucking bankrupting people who need it!!] A need therefore exists for alternative treatment strategies.

Study Design and Outcomes

The first-in-human study included 14 participants aged 28 to 75 years, with body mass indices ranging from 24 to 40 kg/m². Each participant underwent the ReCET procedure under deep sedation, a treatment intended to improve the body’s sensitivity to its own insulin. Following the procedure, participants adhered to a two-week isocaloric liquid diet, after which semaglutide was gradually titrated up to 1mg/week.

Remarkably, at the 6- and 12-month follow-up, 86% of participants (12 out of 14) no longer required insulin therapy, and this success continued through the 24-month follow-up. In these cases, all patients maintained glycaemic control, with HbA1c levels remaining below 7.5%.

Tolerability and Safety

The maximum dose of semaglutide was well-tolerated by 93% of participants, one individual could not increase to the maximum dose due to nausea. All patients successfully completed the ReCET procedure, and no serious adverse effects were reported.

Dr Celine Busch, lead author of the study, commented, “These findings are very encouraging, suggesting that ReCET is a safe and feasible procedure that, when combined with semaglutide, can effectively eliminate the need for insulin therapy.”

“Unlike drug therapy, which requires daily medication adherence, ReCET is compliance-free [meaning: you don't have to take it every day], addressing the critical issue of ongoing patient adherence in the management of T2D. In addition, the treatment is disease-modifying: it improves the patient’s sensitivity to their own (endogenous) insulin, tackling the root cause of the disease, as opposed to currently available drug therapies, that are at best disease-controlling.”

Looking ahead, the researchers plan to conduct larger randomized controlled trials to further validate these findings. Dr. Busch added, “We are currently conducting the EMINENT-2 trial with the same inclusion and exclusion criteria and administration of semaglutide, but with either a sham procedure or ReCET. This study will also include mechanistic assessments to evaluate the underlying mechanism of ReCET.”

-via SciTechDaily, October 17, 2024

--

Note: If it works even half as well as suggested, this could free so many people from the burden of the ongoing ridiculous cost of insulin. Pharma companies that make insulin can go choke (hopefully).

[ruporas]

trigunned the hades or hadesed the trigun (id in alt)

[hyperbali]

Well this feels a little foreboding

[timelessbian]

actually that ao3 post about calculating kudos-to-hits ratios to decide if a fic is worth reading has me so pissed off. someone put real time and energy into something they are SHARING WITH YOU FOR FREE on a site where you can quite literally filter and search by anything you want and you're STILL trying to find a foolproof method to find stuff that's "good enough to read"???

YOU ARE NOT THE TARGET AUDIENCE FOR EVERYTHING

you don't have to like or read everything in a given fandom or tag, but you also don't have to be a cunt about it and imply that it's not worth reading. this is the kind of shit that moves people to stop creating altogether, and to see people agreeing in the tags is so disheartening. absolutely unserious behavior.

[mythicalcoolkid]

You don't wish your disability was worse or more visible, you wish your disability was taken seriously. Please stop confusing the two, I guarantee you would not get the support you need JUST by being more severe or more visible. Please listen to visibly disabled people when we tell you it isn't better on our side

[i-will-cry-you-a-river]

If Shen Yuan would have transmigrated after realizing his sexuality, SVSSS would have been even more unhinged.

Like, he already notices the beautiful men he is surrounded by, but now these beautiful men could be an option for him. Sure, not LBH because he is the protagonist of a stallion novel, he will get his harem of pretty flowers, but the others! After all, if all women belongs to the protagonist, maybe it wouldn't be frowned upon for the men to be cutsleeves. Right? His cute little white sheep will have all the peerless beauties, but the other men who also deserve love and appreciation and care will have no one and that would be a crime.

Now, he just has to figure out which one of his beautiful and handsome and reliable and strong martial brothers is open to have a... a closer relationship with him. I mean, one of them has to be at least a little bit queer, right?! That's just statistics!

[verflares]

(click for higher quality!) draconified link concept ive been chipping away at this past week ..... here's my funny little compendium concept for him:

"A heroic spirit has taken the form of this bestial dragon. Unlike it's kin, this creature exhibits an extremely aggressive disposition. It appears highly territorial, and will relentlessly chase down those who disturb its skywide patrols - of which it seems to be endlessly searching for either a long-time vassal or foe. Unfortunately, it seems the spirit within has long since forgotten exactly who it was looking for…"

[chloesimaginationthings]

I can’t wait to see mangle in the FNAF 2 movie,,