#samplings

[flufflecat]

thinking about ford "human blood tastes better" pines

ford "i have been desiring blood more than usual" pines

stanford "was bitten by a fruit bat but still wrote the sentence 'i have been desiring blood more than usual'" pines

[unsettlingcreature]

(NO LONGER BOOPING EVERYONE WHO REBLOGS, THERE'S TOO MANY OF YOU)

[shinseifer]

"average cat owner spends 3 years in prison" factoid actualy just statistical error. average owner spends 0 years in prison. Miette's mother, who kicked her body like the football and went to jail for One Thousand Years is an outlier adn should not have been counted

[weirdgirlvampire]

If yes, tell me what it is in the tags!

[lonelyroommp3]

yesterday my flatmate asked what my "olympics schedule" was in terms of what i was planning to watch and when and i was like i can't explain to you how much of a foreign concept that is to me. you don't have an "olympics schedule" in my household you watch whatever happens to be on tv whenever you have a minute of free time and get insanely invested in whatever sport you end up watching. maybe down the line you get so caught up in an event that you start going "i'm sorry i need to have the tv at 8:45pm next tuesday because i need to see the men's sport climbing finals or i'll kill myself" but it's something that has to happen organically you know. that's half the fun

[galactic-glossolalia]

I've noticed at a lot of the social stuff I go to now, I'm one of the few there who doesn't drink, and I was reminded of the smoking poll. So now I'm curious.

(See below poll for some notes)

*"regularly" meaning you drink even when there's no occasion to motivate it. Basically, not just social drinking.

**If you've had alcohol before but don't drink anymore for any reason, choose no.

This is a ZERO JUDGMENT poll! Every answer is equally valid, and you DO NOT have to explain your answer if you don't want to!

[hinamie]

morning glory

[certifiedfae]

saw a poll about dry/humid heat and like OBVIOUSLY everyone preferred dry heat but. would love to know what everyone considers to be “too hot”

me personally it’s a hard cutoff at 75°F. don’t need anything more than that thank you 🫶🫶🫶

[softwaring]

[arugulaeater]

desert creature on the phone: it's not that hot today it's like a comfortable 104 (degrees Fahrenheit; 40 in Celsius) !

me (snow creature from snow land): there is no such thing

no nuance you must pick one

[cottonspotten]

*person has consented to being eaten; they’ve donated their body. they died without suffering. you can cook the meat. you will not get sick from the meat.

bonus: explain why!

[lunarflwrs]

my therapist was a bit shook by how much i detest my period, and i was shocked to find out out not everyone does....

[reasonsforhope]

A new treatment combining ReCET and semaglutide could eliminate the need for insulin in type 2 diabetes, with 86% of participants in a study no longer requiring insulin therapy. The treatment was safe and well-tolerated, and further trials are planned to confirm these results.

Groundbreaking research presented at UEG Week 2024 introduces a promising new treatment approach for type 2 diabetes (T2D) that has the potential to greatly reduce or even eliminate the need for insulin therapy.

This innovative approach, which combines a novel procedure known as ReCET (Re-Cellularization via Electroporation Therapy) with semaglutide, resulted in the elimination of insulin therapy for 86% of patients.

Globally, T2D affects 422 million people... While insulin therapy is commonly used to manage blood sugar levels in T2D patients, it can result in side effects... and further complicate diabetes management. [Note: Also very importantly it's fucking bankrupting people who need it!!] A need therefore exists for alternative treatment strategies.

Study Design and Outcomes

The first-in-human study included 14 participants aged 28 to 75 years, with body mass indices ranging from 24 to 40 kg/m². Each participant underwent the ReCET procedure under deep sedation, a treatment intended to improve the body’s sensitivity to its own insulin. Following the procedure, participants adhered to a two-week isocaloric liquid diet, after which semaglutide was gradually titrated up to 1mg/week.

Remarkably, at the 6- and 12-month follow-up, 86% of participants (12 out of 14) no longer required insulin therapy, and this success continued through the 24-month follow-up. In these cases, all patients maintained glycaemic control, with HbA1c levels remaining below 7.5%.

Tolerability and Safety

The maximum dose of semaglutide was well-tolerated by 93% of participants, one individual could not increase to the maximum dose due to nausea. All patients successfully completed the ReCET procedure, and no serious adverse effects were reported.

Dr Celine Busch, lead author of the study, commented, “These findings are very encouraging, suggesting that ReCET is a safe and feasible procedure that, when combined with semaglutide, can effectively eliminate the need for insulin therapy.”

“Unlike drug therapy, which requires daily medication adherence, ReCET is compliance-free [meaning: you don't have to take it every day], addressing the critical issue of ongoing patient adherence in the management of T2D. In addition, the treatment is disease-modifying: it improves the patient’s sensitivity to their own (endogenous) insulin, tackling the root cause of the disease, as opposed to currently available drug therapies, that are at best disease-controlling.”

Looking ahead, the researchers plan to conduct larger randomized controlled trials to further validate these findings. Dr. Busch added, “We are currently conducting the EMINENT-2 trial with the same inclusion and exclusion criteria and administration of semaglutide, but with either a sham procedure or ReCET. This study will also include mechanistic assessments to evaluate the underlying mechanism of ReCET.”

-via SciTechDaily, October 17, 2024

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Note: If it works even half as well as suggested, this could free so many people from the burden of the ongoing ridiculous cost of insulin. Pharma companies that make insulin can go choke (hopefully).

[guiltyidealist]

On your MOST FOLLOWED blog on Tumblr,